Science Progress最新文献

{"title":"Endovascular Perclose ProGlide complication puncture site, treated successful by cutting balloon dilatation: A case report and literature review.","authors":"Yulong Huang, Xinsheng Xie, Lixin Wang","doi":"10.1177/00368504241278481","DOIUrl":"https://doi.org/10.1177/00368504241278481","url":null,"abstract":"<p><p>Perclose ProGlide were created as preferred for puncture site closure of femoral artery. Femoral artery occlusion is one of the serious device-related complications. This report presents a continuous endovascular technique combined with peripheral cutting balloon (PCB) treatment for a case of a 32s woman diagnosed with lower extremity ischaemia caused by right superficial femoral artery (SFA) occlusion following the use of the Perclose ProGlide system in minimally invasive cardiac surgery. During the primary operation, limb ischaemia symptoms were relieved with vessel perfusion and reconstruction after regular balloon dilatation. A secondary operation was conducted 6 weeks later, and the obstructive lesions were recanalised without residual stenosis after PCB dilatation. No vessel-related adverse events such as dissection, rupture or distal embolisation occurred during the perioperative period. The patient recovered uneventfully after the operation, with complete alleviation of symptoms. Follow-up computed tomography angiography 3 month post-operatively revealed an undeformed shape and excellent patency of the right SFA.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 3","pages":"368504241278481"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11403694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporation of decellularized-ECM in graphene-based scaffolds enhances axonal outgrowth and branching in neuro-muscular co-cultures.","authors":"Carlos Serna, Kirtana Sandepudi, Rebecca L Keate, Sophia L Zhang, Kristen Y Cotton, Alberto De La Isla, Matias Murillo, Yasmine Bouricha, Andrea A Domenighetti, Colin K Franz, Sumanas W Jordan","doi":"10.1177/00368504241281469","DOIUrl":"10.1177/00368504241281469","url":null,"abstract":"<p><p>Peripheral nerve and large-scale muscle injuries result in significant disability, necessitating the development of biomaterials that can restore functional deficits by promoting tissue regrowth in an electroactive environment. Among these materials, graphene is favored for its high conductivity, but its low bioactivity requires enhancement through biomimetic components. In this study, we extrusion printed graphene-poly(lactide-co-glycolide) (graphene) lattice scaffolds, aiming to increase bioactivity by incorporating decellularized extracellular matrix (dECM) derived from mouse pup skeletal muscle. We first evaluated these scaffolds using human-induced pluripotent stem cell (hiPSC)-derived motor neurons co-cultured with supportive glia, observing significant improvements in axon outgrowth. Next, we tested the scaffolds with C2C12 mouse and human primary myoblasts, finding no significant differences in myotube formation between dECM-graphene and graphene scaffolds. Finally, using a more complex hiPSC-derived 3D motor neuron spheroid model co-cultured with human myoblasts, we demonstrated that dECM-graphene scaffolds significantly improved axonal expansion towards peripheral myoblasts and increased axonal network density compared to graphene-only scaffolds. Features of early neuromuscular junction formation were identified near neuromuscular interfaces in both scaffold types. These findings suggest that dECM-graphene scaffolds are promising candidates for enhancing neuromuscular regeneration, offering robust support for the growth and development of diverse neuromuscular tissues.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 3","pages":"368504241281469"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coordinated changes in sensorimotor integration underlie behavioral change through evolution and plasticity: A case study in weakly electric mormyrid fish.","authors":"Matasaburo Fukutomi, Bruce A Carlson","doi":"10.1177/00368504241269438","DOIUrl":"10.1177/00368504241269438","url":null,"abstract":"","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 3","pages":"368504241269438"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11307337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141898984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a seven-strain probiotic on dietary intake, inflammatory markers, and T-cells in severe traumatic brain injury patients: A randomized, double-blind, placebo-controlled trial.","authors":"Seyed Hamze Abbaszadeh, Mehdi Yousefi, Seyed Rafie Arefhosseini, Ata Mahmoodpoor, Mehrangiz Ebrahimi Mameghani","doi":"10.1177/00368504241259299","DOIUrl":"10.1177/00368504241259299","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory processes are key factors in pathological events associated with severe traumatic brain injury (STBI). The aim of this trial was to determine the effect of probiotics on anthropometric measures, disease severity, inflammatory markers, and T cells in patients with STBI.</p><p><strong>Methods: </strong>Forty adult patients with STBI were enrolled in this parallel randomized, double-blind, placebo-controlled trial. Energy and protein status, Acute Physiology and Chronic Health Evaluation (APACHE II) score, Sequential Organ Failure Assessment (SOFA), interleukin 10 (IL-10), interleukin 1β (IL-1β), tumor necrosis factor-alpha (TNF-α), transforming growth factor beta (TGF-β), T-helper 17 (Th17), and T- Regulator (T-reg) cells were assessed at baseline (day 1), and week 2 (day 14) for each patient.</p><p><strong>Results: </strong>Probiotic supplementation led to a substantial reduction in the serum levels of TNF-α (from 10.15 ± 6.52 to 5.05 ± 3.27) (<i>P</i> = 0.034), IL-1β (from 11.84 ± 7.74 to 5.87 ± 3.77) (<i>P</i> < 0.001), and Th17 cells (from 5.19 ± 1.69 to 2.67 ± 1.89) (<i>P</i> < 0.001) and a substantial increase in the serum levels of IL-10 (from 3.35 ± 1.45 to 6.17 ± 2.04) (<i>P</i> = 0.038), TGF-β (from 30.5 ± 15.27 to 46.25 ± 21.05) (<i>P</i> < 0.001), and T-reg cells (from 2.83 ± 1.43 to 4.29 ± 1.89) (<i>P</i> < 0.001) compared with the placebo group. Furthermore, no notable changes were observed in energy and protein intake and also, terms of SOFA and APACHE II scores following probiotic treatment compared with the placebo.</p><p><strong>Conclusions: </strong>Probiotics could reduce inflammation and improve cellular immunity and may be considered as an adjunctive therapy in STBI patients.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 3","pages":"368504241259299"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142082642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing 3D-printed denture base resins: A review of material innovations.","authors":"Hadeel Fikrat Majeed, Thekra Ismael Hamad, Latifa R Bairam","doi":"10.1177/00368504241263484","DOIUrl":"10.1177/00368504241263484","url":null,"abstract":"<p><p>The limited physical and mechanical properties of polymethyl methacrylate (PMMA), the current gold standard, necessitates exploring improved denture base materials. While three-dimensional (3D) printing offers accuracy, efficiency, and patient comfort advantages, achieving superior mechanics in 3D-printed denture resins remains challenging despite good biocompatibility and esthetics. This review investigates the potential of innovative materials to address the limitations of 3D-printed denture base materials. Thus, this article is organized to provide a comprehensive overview of recent efforts to enhance 3D-printed denture base materials, highlighting advancements. It critically examines the impact of incorporating various nanoparticles (zirconia, titania, etc.) on these materials' physical and mechanical properties. Additionally, it delves into recent strategies for nanofiller surface treatment and biocompatibility evaluation and explores potential future directions for polymeric composites in denture applications. The review finds that adding nanoparticles significantly improves performance compared to unmodified resins, and properties can be extensively enhanced through specific modifications, particularly silanized nanoparticles. Optimizing 3D-printed denture acrylics requires a multifaceted approach, with future research prioritizing novel nanomaterials and surface modification techniques for a novel generation of superior performance, esthetically pleasing, and long-lasting dentures.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 3","pages":"368504241263484"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11271118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Want to learn? think again!","authors":"Erez Geron","doi":"10.1177/00368504241266577","DOIUrl":"10.1177/00368504241266577","url":null,"abstract":"<p><p>One of the best ways to improve new learning and increase memory strength is by reprocessing the recently acquired information, for example, by thinking of it again. Synaptic plasticity, the process by which neurons change the strength of their connections with each other, is fundamental for learning and memory formation. Yet, at present, it is unclear how reprocessing information drives synaptic plasticity to support memory improvement. A new study suggests that reprocessing enhances memory formation by recruiting more synapses to represent the new memory, thus increasing its strength.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 3","pages":"368504241266577"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11271117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141753489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin exposure and the incidence of lactic acidosis in critically ill patients with T2DM: A retrospective cohort study.","authors":"Jingkai Tong, Xin Li, Tong Liu, Ming Liu","doi":"10.1177/00368504241262116","DOIUrl":"10.1177/00368504241262116","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to investigate the correlation between metformin exposure and the incidence of lactic acidosis in critically ill patients.</p><p><strong>Methods: </strong>The patients with type 2 diabetes mellitus (T2DM) were included from Medical Information Mart for Intensive Care IV database (MIMIC-IV). The primary outcome was the incidence of lactic acidosis. The secondary outcomes were lactate level and in-hospital mortality. Propensity score matching (PSM) method was adopted to reduce bias of the confounders. The multivariate logistic regression was used to explore the correlation between metformin exposure and the incidence of lactic acidosis. Subgroup analysis and sensitivity analysis were used to test the stability of the conclusion.</p><p><strong>Results: </strong>We included 4939 patients. There were 2070 patients in the metformin group, and 2869 patients in the nonmetformin group. The frequency of lactic acidosis was 5.7% (118/2070) in the metformin group and it was 4.3% (122/2869) in the nonmetformin group. There was a statistically significant difference between the two groups (<i>P < </i>0.05). The lactate level in the metformin group was higher than in the nonmetformin group (2.78 ± 2.23 vs. 2.45 ± 2.24, <i>P < </i>0.001). After PSM, the frequency of lactic acidosis (6.3% vs. 3.7%, <i>P </i>< 0.001) and lactate level (2.85 ± 2.38 vs. 2.40 ± 2.14, <i>P < </i>0.001) were significantly higher in the metformin group compared with the nonmetformin group. In multivariate logistic models, the frequency of lactic acidosis was obviously increased in metformin group, and the adjusted odds ratio (<i>OR</i>) of metformin exposure was 1.852 (<i>95% confidence interval (CI) = </i>1.298-2.643, <i>P </i>< 0.001). The results were consistent with subgroup analysis except for respiratory failure subgroup. Metformin exposure increased lactate level but did not affect the frequency of lactic acidosis in patients of respiratory failure with hypercapnia. However, the in-hospital mortality between metformin and nonmetformin group had no obvious difference (<i>P </i>= 0.215). In sensitivity analysis, metformin exposure showed similar effect as the original cohort.</p><p><strong>Conclusions: </strong>In critically ill patients with T2DM, metformin exposure elevated the incidence of lactic acidosis except for patients of respiratory failure with hypercapnia, but did not affect the in-hospital mortality.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 3","pages":"368504241262116"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11282515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent developments in understanding RIG-I's activation and oligomerization.","authors":"Justyna Sikorska, Daniel F Wyss","doi":"10.1177/00368504241265182","DOIUrl":"10.1177/00368504241265182","url":null,"abstract":"<p><p>Insights into mechanisms driving either activation or inhibition of immune response are crucial in understanding the pathology of various diseases. The differentiation of viral from endogenous RNA in the cytoplasm by pattern-recognition receptors, such as retinoic acid-inducible gene I (RIG-I), is one of the essential paths for timely activation of an antiviral immune response through induction of type I interferons (IFN). In this mini-review, we describe the most recent developments centered around RIG-I's structure and mechanism of action. We summarize the paradigm-changing work over the past few years that helped us better understand RIG-I's monomeric and oligomerization states and their role in conveying immune response. We also discuss potential applications of the modulation of the RIG-I pathway in preventing autoimmune diseases or induction of immunity against viral infections. Overall, our review aims to summarize innovative research published in the past few years to help clarify questions that have long persisted around RIG-I.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 3","pages":"368504241265182"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11297509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aetiology and management of persistent withdrawal occlusion in venous ports in oncology patients.","authors":"V Maňásek, J Zapletalová, L Olosová, I Filáková, I Kociánová, K Drdová, J Škarda, V Chovanec, D Vrána","doi":"10.1177/00368504241260374","DOIUrl":"10.1177/00368504241260374","url":null,"abstract":"<p><strong>Introduction: </strong>Persistent withdrawal occlusion (PWO) is a specific catheter malfunction characterized by the inability to withdraw blood through the device. The most common cause of PWO in ports is the presence of a fibroblastic sleeve (FS). If malfunction occurs, medication can be applied incorrectly with the increased risk of complications.</p><p><strong>Methods: </strong>One hundred seventy-seven cases of PWO in venous ports were managed. We focused on evaluating the cause of PWO, the frequency of occurrence of FS, and the options to address the malfunction. The patients underwent fluoroscopy with a contrast agent administration. Mechanical disruption (MD) with a syringe of saline using the flush method was used; in case of its failure, subsequent administration of a lock solution with taurolidine and urokinase, or low-dose thrombolysis with alteplase was indicated. Demographic data were compared with a control group.</p><p><strong>Results: </strong>A significantly higher proportion of female patients was found in the cohort of patients with PWO (80.3% vs 66.3%, <i>p</i> = 0.004), dominantly patients with ovarian cancer (12.8% vs 4.8%, <i>p</i> = 0.022). No effect of the cannulated vein or the type of treatment on the incidence of PWO was demonstrated. The presence of FS was verified in 70% of cases. MD with a syringe was successful in 53.5% of cases. A significantly shorter time to referral (3 weeks) was demonstrated with successful management. The overall success rate of achieving desobliteration by MD alone or in combination with a thrombolytic (urokinase or alteplase) administration was 97.4%.</p><p><strong>Conclusion: </strong>We created a method for resolving PWO using MD +/- application of thrombolytics with 97.4% success rate. Current evidence showed that FS is not likely to be affected by thrombolytic drugs; however, we have ascertained an effect of these drugs, proposing a hypothesis of microthrombotic events at the tip of the catheter if fibroblastic sleeve is present.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 3","pages":"368504241260374"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement of ultra-short-term heart rate variability measure after different repeated bouts of sprint ability tests.","authors":"Chin-Hwai Hung, Wan-An Lu, Jeffrey Cayaban Pagaduan, Cheng-Deng Kuo, Yung-Sheng Chen","doi":"10.1177/00368504241262150","DOIUrl":"10.1177/00368504241262150","url":null,"abstract":"<p><p>This study aims to explore: (1) the validity of post-exercise ultra-short-term heart rate variability (HRV_ust) after two different bouts of repeated sprint ability test (RSA), and (2) the relationship between HRV_ust measure and RSA performance. Twenty adolescent male futsal players voluntarily participated in this study (age: 17.65 ± 1.81 years, body height: 170.88 ± 4.98 cm, body weight: 61.78 ± 4.67 kg). The participants performed a standard RSA test (RSA_standard) and an RSA test with a 10% decrement of the best sprint time test (RSA_10%decrement) on two separate occasions within a week. On both occasions, a 5-min resting electrocardiography was administered pre- and post-RSA exercise protocols. The first 30-s (HRV_ust30s), 60-s (HRV_ust60s), and 60-120-s (HRV_ust1-2min) were extracted and used to compare with the standard of 5-min HRV recording (HRV_criterion). The natural logarithm (ln) of the standard deviation of normal-to-normal intervals (SDNN) and root mean square of successive normal-to-normal interval differences (RMSSD) HRV indices were utilised to establish intraclass correlation coefficient (ICC_2,1), coefficient of variation (%CV), and Pearson product-moment correlation (<i>r</i>). Results revealed the ICC values of HRV_ust lnSDNN (RSA_standard = 0.77-0.88; RSA_10%decrement = 0.41-0.71) and lnRMSSD (RSA_standard = 0.81-0.86; RSA_10%decrement = 0.57-0.82). Furthermore, significantly positive correlations between best sprint time and post-exercise HRV_ust indices were found in lnSDNN (<i>r </i>= 0.47-0.62; <i>p </i>< 0.05) and lnRMSSD (<i>r </i>= 0.45; <i>p </i>< 0.05). Additionally, a large CV of lnSDNN (RSA_standard = 32%-45%; RSA_10%decrement = 29%-39%), lnRMSSD (RSA_standard = 50%-66%; RSA_10%decrement = 48%-52%), and ratio (RSA_standard = 45%-126%; RSA_10%decrement = 27%-45%) was found after the RSA protocols. In conclusion, the number of bouts of RSA exercise potentially influences the agreement of post-exercise time-domain HRV_ust indices to standard HRV measure.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 3","pages":"368504241262150"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}