Science Progress最新文献

{"title":"Diagnostic values of TPT1 in patients with sepsis, septic shock and in non-infected controls: A single-center prospective observational cohort study in ICU patients.","authors":"Gelan Miao, Dexiu Chen, Xuelian Yang, Yulian Yang, Qidong Jiang, Li Liu, Xianying Lei","doi":"10.1177/00368504251363429","DOIUrl":"10.1177/00368504251363429","url":null,"abstract":"<p><p>ObjectiveTo evaluate the diagnostic value of tumor protein translationally-controlled 1 (TPT1) in patients with sepsis and septic shock in the intensive care unit (ICU).MethodsThis single-center, prospectively planned observational study included 53 ICU patients with sepsis (30 with non-shock sepsis, 23 with septic shock) and 20 non-infected ICU controls. Plasma levels of TPT1, procalcitonin (PCT), and C-reactive protein (CRP) were measured on day 1 of ICU admission. Diagnostic performance was assessed using receiver operating characteristic (ROC) analysis.ResultsTPT1 levels were associated with higher SOFA scores and serum creatinine levels (<i>p</i> < 0.01). TPT1 levels were consistently significantly higher in non-shock sepsis and septic shock patients than in non-infected controls (<i>p</i> < 0.001). On day 1, plasma TPT1 levels effectively differentiated non-shock from septic shock (<i>p</i> < 0.01). TPT1 has good diagnostic value for sepsis and septic shock (AUC 0.80 and 0.94, respectively, <i>p</i> < 0.0001). TPT1 levels were significantly elevated in both non-shock sepsis and septic shock groups compared to non-infected controls (<i>p</i> < 0.001). TPT1 also showed a positive correlation with SOFA score and serum creatinine (<i>p</i> < 0.01). The area under the ROC curve (AUC) for TPT1 was 0.80 for sepsis and 0.94 for septic shock (<i>p</i> < 0.0001), indicating moderate to high diagnostic accuracy. TPT1 outperformed CRP and PCT in distinguishing septic shock from non-shock sepsis (AUC = 0.71).ConclusionsTPT1 has significant value as a diagnostic marker in sepsis and septic shock, with diagnostic capabilities comparable to procalcitonin and C-reactive protein.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251363429"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainable innovation in foamed concrete using waste sanitary ware as fine aggregate for properties enhancement.","authors":"Md Azree Othuman Mydin, Nadhim Hamah Sor, Mohd Mustafa Al Bakri Abdullah, Haytham F Isleem, Anmar Dulaimi, Paul O Awoyera, Olaolu George Fadugba, Taher A Tawfik","doi":"10.1177/00368504251375175","DOIUrl":"10.1177/00368504251375175","url":null,"abstract":"<p><p>The solid waste generated by the waste sanitary ware (WSW) sector is of considerable magnitude on a global scale. Recycling ceramic waste is an essential practice that ensures its proper disposal. Therefore, the objective of this research endeavor was to investigate the effects of replacing sand with WSW on different characteristics of foamed concrete (FC), such as its thermal properties, transportability, freshness, and mechanical strengths. A range of replacement rates, ranging from 5% to 25%, was considered. The utilization of WSW replacements increases the initial and final setting times, along with the densities of the mixtures, according to the test results. Nevertheless, the slump of the fresh test decreases. Significant improvements were observed in the mechanical characteristics when the replacement ratio was established at 10%. Furthermore, the results of the scanning electron microscopy evaluation and pore distribution analysis indicated that the performance of FC containing up to 10% WSW was superior as a filler for pores. Also, the addition of WSW resulted in a decrease in sorptivity, porosity, and water absorption. Nevertheless, the thermal conductivity of FC was enhanced. Nevertheless, considering the comprehensive examination, the most optimal approach to manufacturing environmentally friendly FC may involve replacing 10% of WSW.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251375175"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complement and local ocular inflammatory response: Chronic immune factors in myopia.","authors":"Mengdi Zhang, Ya Mo, Jia Gao, Wenjia Qu, AnQi Chen, ShiQi Wu, Yan Zhang","doi":"10.1177/00368504251383046","DOIUrl":"10.1177/00368504251383046","url":null,"abstract":"<p><p>Myopia has emerged as a globally pervasive visual disorder, with its incidence rising steadily, particularly among children and adolescents, posing a significant threat to ocular health. Recent research underscores a strong link between chronic inflammatory processes and both the onset and progression of myopia. As a cornerstone of the innate immune system, the complement cascade plays a pivotal role in mediating ocular inflammatory diseases associated with high myopia, including macular degeneration, glaucoma, allergic conjunctivitis, uveitis, and scleritis. Accumulating evidence indicates that complement activation contributes to myopia pathogenesis by orchestrating local inflammatory responses within the eye. This article is a narrative review that synthesizes current evidence on complement-myopia interactions, with a focus on the underlying biological mechanisms and their potential as therapeutic targets for both preventing and managing myopia.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251383046"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular advances in early-stage and locally advanced non-small cell lung carcinoma: Shaping the future of precision oncology-systematic review.","authors":"Wael Abdo Hassan","doi":"10.1177/00368504251383055","DOIUrl":"10.1177/00368504251383055","url":null,"abstract":"<p><p>ObjectiveTo synthesize recent molecular advances that inform diagnosis, risk-stratification, and perioperative treatment in early-stage and locally advanced non-small cell lung carcinoma (NSCLC), with emphasis on comprehensive genomic profiling, minimal residual disease (MRD) detection by circulating tumor DNA (ctDNA), and the translation of biomarkers into targeted and immunotherapy strategies.MethodsSystematic review registered in PROSPERO (CRD420251076423). Searches of PubMed, Scopus, Web of Science, and Embase (January 2015-April 2025) followed PRISMA 2020/PRISMA-S. From 4640 records, 890 duplicates were removed; 3750 titles/abstracts were screened; 150 full texts were assessed; 75 studies met inclusion criteria. Risk of bias used Newcastle-Ottawa Scale (NOS) for observational studies and Cochrane RoB 2 tool for randomized controlled trials; certainty was summarized with GRADE where applicable.ResultsActionable alterations (e.g. EGFR, ALK, KRAS, MET, RET, BRAF, NTRK) are prevalent in early-stage NSCLC and comparable to advanced disease, supporting routine comprehensive genomic profiling in curative-intent settings. Next-generation sequencing (NGS) and ctDNA enable the detection of MRD, earlier relapse prediction, and dynamic treatment monitoring. Perioperative strategies integrating targeted therapy and immunotherapy (e.g. adjuvant EGFR-TKI, neoadjuvant chemo-immunotherapy) improve pathological and disease-free outcomes in selected biomarker-defined populations. Evidence profiles generally show low-to-moderate risk of bias and moderate-to-high certainty for key outcomes related to profiling and MRD, with heterogeneity across platforms and endpoints.ConclusionsMolecular advances-particularly broad NGS and ctDNA-based MRD-are reshaping the perioperative management of early and locally advanced NSCLC, enabling precision selection for targeted and immunotherapy approaches. Standardization of testing workflows and reporting, and cost-effective implementation are priorities for equitable adoption and for future trials that combine NGS, MRD, and multi-omic/AI-driven risk stratification.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251383055"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12461064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145132862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing body fat prediction with WGAN-GP data augmentation and XGBoost algorithm.","authors":"Xiangyu Wang, Shuai Chang","doi":"10.1177/00368504251366850","DOIUrl":"10.1177/00368504251366850","url":null,"abstract":"<p><p>Background and ObjectiveMachine learning models offer a practical approach for estimating body fat percentage from simple anthropometric data. However, the scarcity of biomedical data frequently leads to model overfitting, compromising predictive accuracy. Generative data augmentation presents a promising strategy to address this limitation. This study develops and evaluates a generative data augmentation framework to enhance body fat prediction from limited anthropometric data.MethodsA public dataset comprising 249 male subjects was partitioned into development (80%) and test (20%) sets. The fidelity of Wasserstein Generative Adversarial Network with Gradient Penalty (WGAN-GP), random noise injection, and mixup was compared to select the optimal method. Subsequently, XGBoost, Support Vector Regression, and Multi-layer Perceptron models were trained and validated, comparing performance with and without the selected augmentation. Final model generalization was assessed on the independent test set using the coefficient of determination (R²), Mean Absolute Error, and Root Mean Squared Error.ResultsAmong the evaluated augmentation techniques, the WGAN-GP generated synthetic data with the highest fidelity. On the original data, the baseline XGBoost model achieved a R² of 0.67; this performance increased to 0.77 on the test set when using WGAN-GP augmentation. Feature importance analysis of the final model identified abdominal circumference as the most significant predictor of body fat percentage.ConclusionThe WGAN-GP is a highly effective method for generating realistic synthetic anthropometric data. Integrating these synthetic samples into the training pipeline substantially improves the generalization and predictive accuracy of machine learning models. This methodology offers a robust solution for developing more accurate and accessible predictive health models in data-scarce environments.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251366850"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between multivessel disease and outcomes in acute lower limb ischemia: A cohort study.","authors":"Simão Almeida-Oliveira, João Rocha-Neves, Leonardo Araujo-Andrade, Mariana Fragao Marques, Tomasz Goryń, Izabela Taranta, Włodzimierz Hendiger, Hugo Ribeiro, Piotr Myrcha","doi":"10.1177/00368504251355146","DOIUrl":"10.1177/00368504251355146","url":null,"abstract":"<p><p>ObjectiveAcute lower limb ischemia (ALI) is closely linked to conditions like diabetes mellitus and peripheral arterial disease, as well as the presence of polyvascular disease (PVD). The present retrospective observational study aimed to evaluate the impact of PVD on perioperative outcomes in patients with ALI.MethodsAmong 161 consecutive patients, these were categorized into subgroups based on their PVD status: control (<i>N</i> = 81), PVD1 (single arterial bed involvement) (<i>N</i> = 62), and PVD2 (coronary and cerebrovascular) (<i>N</i> = 18). Descriptive statistics and univariate analysis were performed.ResultsThe mean age was 71.17 ± 11.6. Higher prevalences of diabetes mellitus (<i>n</i> = 21, 33.9% in PVD1; <i>n</i> = 8, 44.4% in PVD2) and hypertension (<i>n</i> = 55, 88.7% in PVD1; <i>n</i> = 16, 88.9% in PVD2) were reported for the PVD groups, when comparing to controls, who registered 13 (16.0%) and 41 (50.6%) individuals, respectively. Anticoagulant therapy and acute myocardial infarction were more common in the PVD1 and PVD2 groups (<i>p</i> = 0.005 and <i>p</i> = 0.001). Non-cardiovascular mortality rates were significantly higher in the PVD groups, with 24.2% in PVD1 and 33.3% in PVD2 compared to 11.1% in the control group (<i>p</i> = 0.033).ConclusionsThe study concluded that PVD significantly impacts the status of ALI patients, emphasizing the need for tailored, multidisciplinary care.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251355146"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12365456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of hemodynamic and functional variables with pulmonary vasculopathy in lung transplant recipients living at high altitude: A retrospective study.","authors":"Rafael Conde-Camacho, Eduardo Tuta-Quintero, Fabio Varón-Vega, Jacqueline Mugnier, Libardo Marmolejo, Diego Severiche, Luis F Giraldo-Cadavid","doi":"10.1177/00368504251367283","DOIUrl":"10.1177/00368504251367283","url":null,"abstract":"<p><p>ObjectivePulmonary hypertension is a heterogeneous syndrome with diverse underlying etiologies. This study aimed to evaluate the association between preoperative hemodynamic parameters-assessed by right heart catheterization (RHC) and transthoracic echocardiography (TTE)-and histopathological findings in explanted lungs from transplant recipients residing at high altitude.MethodsWe conducted a retrospective analysis of lung transplant recipients with interstitial lung disease (ILD) who had available RHC and TTE data prior to transplantation. Clinical, functional, hemodynamic, and histopathological variables were collected to assess the presence and severity of pulmonary vasculopathy. Bivariate analyses, correlation tests, and internally validated predictive models were performed to explore these associations.ResultsA total of 38 patients were included (median age: 54 years). The median mean pulmonary artery pressure (mPAP) was 33 mmHg, and the pulmonary artery systolic pressure (PASP) was 42 mmHg. An inverse correlation was observed between vasculopathy grade and the ratio of tricuspid annular plane systolic excursion to PASP (TAPSE/PASP) (<i>r</i> = -0.49, <i>p</i> = 0.007). Trends toward significance were found for percent predicted forced vital capacity (FVC%) (<i>r</i> = -0.30, <i>p</i> = 0.074) and catheter-derived PASP (<i>r</i> = 0.30, <i>p</i> = 0.070). A moderate positive correlation was noted between vasculopathy grade and echocardiographic mPAP (<i>r</i> = 0.41, <i>p</i> = 0.003). Among all parameters evaluated, the product of TAPSE and FVC% demonstrated the highest discriminative ability for vasculopathy (area under the receiver operating characteristic curve [AUC] = 0.790), followed by FVC% (AUC = 0.689) and TAPSE (AUC = 0.678).ConclusionsNoninvasive measures-particularly the TAPSE/PASP ratio and composite indices incorporating FVC%-demonstrate moderate correlation with histopathological evidence of pulmonary vasculopathy in ILD patients living at high altitude. These findings highlight the potential utility of noninvasive tools in the preoperative evaluation of pulmonary vascular disease in this population.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251367283"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe oral and cutaneous immune-related adverse events induced by PD-1 inhibitors and antibody-drug conjugates: Case reports and management strategies.","authors":"Furong Yang, Peiru Zhou, Hong Hua","doi":"10.1177/00368504251364109","DOIUrl":"10.1177/00368504251364109","url":null,"abstract":"<p><p>With increased use of immune checkpoint inhibitors (ICIs) for treating tumors, immune-related adverse events (IrAEs) have risen. Severe cases of anti-PD-1 therapy-induced IrAEs such as Stevens-Johnson syndrome (SJS)-like and toxic epidermal necrolysis (TEN)-like lesions are rare but fatal. We report two cases of patients with malignant tumors who developed oral and cutaneous severe IrAEs: one induced by a PD-1 inhibitor alone and the other by a combination of a PD-1 inhibitor and an antibody-drug conjugates (ADCs). Both of them developed severe lesions resembling erythema multiforme (EM) and SJS, accompanied by lichenoid reactions. Treatment with short-term low-dose oral glucocorticoids with topical glucocorticoids resulted in satisfactory outcomes. These case reports highlight rare and severe IrAEs induced by PD-1 inhibitors and ADCs and demonstrate how optimal outcomes were achieved for patients with severe IrAEs.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251364109"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role and mechanism of abnormal lipid metabolism in colorectal cancer.","authors":"Jinhui Zha, Pengxu Cang, Yonghao Zhong, Ruilin Liu, Gang Fan","doi":"10.1177/00368504251368237","DOIUrl":"10.1177/00368504251368237","url":null,"abstract":"<p><p>Colorectal cancer ranks among the most prevalent and lethal malignant tumors globally. Historically, the incidence of colorectal cancer in China has been lower than that in developed European and American countries; however, recent trends indicate a rising incidence due to changes in dietary patterns and lifestyle. Lipids serve critical roles in human physiology, such as energy provision, cell membrane formation, signaling molecule function, and hormone synthesis. Dysregulation of lipid metabolism is strongly associated with various metabolic disorders, including cardiovascular disease, obesity, hepatic steatosis, and diabetes, as well as tumor initiation, progression, and metastasis. Lipid metabolism significantly contributes to cancer development by facilitating biofilm synthesis, supplying substrates for biomass production, and activating signaling pathways linked to cancer cell proliferation and migration. This narrative review summarizes recent advancements in understanding the regulation of lipid metabolism in colorectal cancer, evaluates potential molecular targets, and highlights relevant clinical trials. All relevant literature was retrieved through a comprehensive search of the PubMed database.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251368237"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the link: Is Parkinson's disease a causal factor for glaucoma? Insights from Mendelian randomization.","authors":"M M Bin Lin, M M Long-Long Chen, M M Mei-Yi Zhu, M D Dong-Kan Li","doi":"10.1177/00368504251377961","DOIUrl":"10.1177/00368504251377961","url":null,"abstract":"<p><p>BackgroundGlaucoma is recognized as the second-leading cause of complete blindness in developed countries and a significant contributor to irreversible vision loss worldwide. Understanding the potential genetic links between neurodegenerative diseases, such as Parkinson's disease, and glaucoma is crucial for developing preventive strategies.MethodsThis study utilized data from Genome-Wide Association Studies databases, focusing on European populations without gender restrictions. Single nucleotide polymorphisms (SNPs) were selected as instrumental variables based on criteria ensuring no direct association with outcomes and independence from confounding factors. Mendelian randomization analyses were conducted to assess the relationship between SNP effect sizes for Parkinson's disease and the risk of developing glaucoma. Finally, detailed information on high-risk SNP loci was queried and compared in the Ensembl gene database to further explore the relationship between the two diseases.ResultsThe analysis revealed that for every one standard deviation increase in the SNP effect size for Parkinson's disease, the risk of developing glaucoma increased by 0.3% to 11.9%. Pleiotropy testing indicated a <i>p</i>-value of 0.464, suggesting that genetic pleiotropy is unlikely to affect the results. Sensitivity analyses confirmed the stability of the findings. A notable observation is the proximity between the loci of both diseases on chromosome 7. However, this positional overlap alone, without functional validation, does not confirm biological relevance.ConclusionThe study provides suggestive evidence of a potential causal relationship, suggesting that genetic factors associated with Parkinson's disease may potentially contribute to an increased risk of glaucoma. These findings tentatively highlight the need to consider neurodegeneration-related mechanisms in glaucoma management and prevention, though further validation is required.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251377961"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}