Science Progress最新文献

{"title":"Clays in transition: Addressing resource challenges and sustainable innovations in the construction sector.","authors":"Milica Vasić, Ivanka Netinger Grubeša, Paul Awoyera, Ivana Barišić","doi":"10.1177/00368504251376483","DOIUrl":"10.1177/00368504251376483","url":null,"abstract":"<p><p>This review examines the reintegration of lower-grade clays into industrial applications, with a focus on ceramics, cementitious binders, and infrastructure materials as key sectors for sustainable transformation. It compiles current research and experimental insights to understand how such materials, often overlooked due to variable composition or limited reactivity, can be adapted to meet sector-specific performance requirements. In ceramic tile production, low-grade clays demonstrate varying degrees of sintering efficiency and thermal shrinkage, compared to traditional kaolin, offering viable paths for cost reduction. In cement applications, contrasts between kaolinite-based and limestone calcinated clay (LC³) reveal trade-offs in strength development, shrinkage behavior, durability, and CO₂ emissions. The review critically examines technical constraints, including mix variability, curing sensitivity, and activation thresholds, while emphasizing the need for regulatory adaptation and economic feasibility. In infrastructure applications, lower-grade clays have demonstrated promising adaptability for use in road base stabilization, where their plasticity and compaction behavior outweigh the demands for high purity. Their mineralogical variability influences moisture sensitivity and load-bearing performance, yet tailored mix designs and hybrid systems can mitigate these effects. The review underscores that while durability and regulatory compliance remain key challenges, these clays offer viable alternatives for low-carbon construction in regions with abundant local deposits. Through a synthesis of empirical findings and methodological analysis, this work contributes to the strategic valorization of underutilized clay sources and supports the advancement of resource-efficient material design.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 4","pages":"368504251376483"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gadolinium-enhanced delayed MRI of inner ear: A valuable diagnostic tool for Ménière's disease and delayed endolymphatic hydrops: A retrospective cohort study.","authors":"Chengcheng Liu, Zi Wang, Wei Gao, Yong Jing, Pengwei Ma, Rui Liang, Jianing Guo, Hongkai Mei, Wen Wang, Guangbin Cui, Lianjun Lu","doi":"10.1177/00368504251382441","DOIUrl":"10.1177/00368504251382441","url":null,"abstract":"<p><p>ObjectiveThe diagnosis of Ménière's disease (MD) and delayed endolymphatic hydrops (DEH) is challenging due to overlapping symptoms. This study aimed to retrospectively evaluate the diagnostic performance of gadolinium-enhanced delayed inner ear magnetic resonance imaging (MRI) for visualizing endolymphatic hydrops (EH) in patients with MD and DEH.MethodsThis retrospective study included 191 patients with unilateral MD (<i>n</i> = 164) or DEH (<i>n</i> = 27), stratified into definite MD (DMD, <i>n</i> = 129), probable MD (PMD, <i>n</i> = 35), and DEH subgroups. All patients underwent intratympanic administration of gadolinium followed by 3.0-T MRI using 3D-FLAIR and 3D-real-IR sequences. Clinical data, including pure-tone audiometry (PTA), speech recognition score (SRS), electrocochleography (ECochG), and caloric testing, were analyzed to assess correlations between EH and auditory-vestibular function.ResultsEH was detected in 85.2% (23/27) of clinically diagnosed DEH patients. Detection rates were 96.1% in DMD cases and 28.6% in PMD cases. There was no significant difference in cochlear or vestibular EH between the DMD and DEH groups. However, the DMD group exhibited a significantly higher incidence and severity of EH than the PMD group (<i>P</i> < 0.05). In DMD patients, the degree of EH was positively correlated with PTA, clinical stage, and disease course (<i>P</i> < 0.05), and negatively correlated with SRS (<i>P</i> < 0.05). The degree of vestibular EH was also positively correlated with caloric test abnormalities (Spearman's ρ = 0.350, <i>P</i> < 0.001).ConclusionGadolinium-enhanced delayed MRI of the inner ear provides objective evidence of EH and improves the diagnostic accuracy for MD and DEH. Its incorporation into standardized diagnostic protocols may further enhance clinical decision-making.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 4","pages":"368504251382441"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12508543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive high-throughput sequencing analysis and verification of miRNAs isolated from bronchial epithelial cells undergoing radiation-induced epithelial-mesenchymal transition.","authors":"Yifan Hou, Shenghui Zhou, Ping Wang, Duo Wang, Yuhao Liu, Xingkun Ao, Xinxin Liang, Jiaojiao Zhu, Ziyan Yan, Xiaochang Liu, Lin Zhou, Huixi Chen, Yan Zeng, Yongqing Gu","doi":"10.1177/00368504251362376","DOIUrl":"10.1177/00368504251362376","url":null,"abstract":"<p><p>Radiation-induced pulmonary fibrosis (RIPF) constitutes a significant complication in radiotherapy for various cancers, often severely limiting its efficacy. Recent studies suggest that epithelial-mesenchymal transition (EMT) plays a vital role in the pathogenesis of RIPF. Elucidating the involvement of microRNAs (miRNAs) in EMT could provide valuable insights into the mechanisms underlying RIPF and potentially reveal therapeutic targets. In this study, twelve dishes of BEAS-2B cells were irradiated with 6 Gy ⁶⁰Co γ-rays, and RNA was extracted at 0, 6, and 48 h after irradiation. High-throughput sequencing analysis of miRNA samples revealed miRNA significant changes in the BEAS-2B cells after irradiation, which was verified by RT-PCR. Additionally, the upstream transcription factors (TFs) were predicted through graphene oxide-based analysis. Transcription factors regulate the expression and transcriptional levels of miRNAs, and their functions may be associated with inflammatory or oxidative stress responses. The functional roles of these TFs were characterized through gene ontology (GO) analysis. Overall, we successfully screened and identified a set of miRNAs associated with ionizing radiation-induced EMT in lung epithelial cells and performed predictive identification of their upstream TFs and downstream regulatory target proteins. These data provide a firm foundation for future studies of the mechanism of radiation-induced EMT processes and related changes in biological function.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251362376"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated computation for 2D isogeometric acoustic model with ground reflection by integrating Taylor expansion and deep neural network.","authors":"Jinfeng Gao, Hehong Ma, Dongqing Miao, Ruxian Yao, Yu Zhang","doi":"10.1177/00368504251357783","DOIUrl":"10.1177/00368504251357783","url":null,"abstract":"<p><p>This article provides a method that combines Taylor expansion and neural network technology to accelerate the solution of an isogeometric acoustic model with ground reflection. The Helmholtz equation for the acoustic problem is solved by the boundary element method (BEM), and the model structure shape is optimized by combining the isogeometric method. In addition, to mitigate the high computational cost arising from repeated evaluations at each discrete frequency point, the Hankel function is approximated via a Taylor series expansion. This approach enables the decoupling of the boundary element method equation into frequency-dependent and frequency-independent terms. After using the deep neural network (DNN) training simulation results, the acoustic results are predicted. The DNN model can effectively analyze the sound field problem. Finally, the accuracy and feasibility of the proposed algorithm are verified by a two-dimensional numerical example.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251357783"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular coil embolization for cerebral aneurysms in the elderly in an aging society.","authors":"Ryokichi Yagi, Ryo Hiramatsu, Hiroyuki Ohnishi, Masahiro Kameda, Naosuke Nonoguchi, Motomasa Furuse, Shinji Kawabata, Toshihiro Takami, Masahiko Wanibuchi","doi":"10.1177/00368504251369728","DOIUrl":"10.1177/00368504251369728","url":null,"abstract":"<p><p>ObjectiveAn aging or aged society is and has been a reality in many developed countries. Additionally, the incidence of subarachnoid hemorrhage (SAH) in elderly patients has been estimated to be increasing. However, the outcomes of SAH treatment by clipping or coiling in elderly patients are poor. Therefore, preventative surgery for elderly patients with unruptured cerebral aneurysm is becoming increasingly important. The aim of this study was to analyze the safety and efficacy of endovascular coil embolization for elderly patients with cerebral aneurysm.MethodsA total of 252 patients (264 aneurysms) who underwent endovascular coil embolization for cerebral aneurysms between April 2012 and August 2018 at our institution were included. This study is retrospective observational study, and we retrospectively investigated treatment outcomes and perioperative complications in nonelderly patients and elderly patients with ruptured or unruptured cerebral aneurysms, who underwent endovascular coil embolization. We defined patients aged < 65 years as nonelderly and aged <u>></u> 65 years as elderly.ResultsAmong the elderly patients with unruptured aneurysms, there was a higher proportion of cases with residual aneurysm as an embolic state immediately after operation and high-intensity spots in magnetic resonance imaging-diffusion-weighted imaging on the day after the operation as compared with the nonelderly. However, there were no differences between nonelderly and elderly patients with regard to the number of cases with modified Rankin Scale 3-5 and 6 at discharge, the number of re-operation, and postoperative rupture.ConclusionsIn this study, endovascular coil embolization was determined to be a safe and efficacious procedure for elderly patients with unruptured cerebral aneurysm.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251369728"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of thrombus-derived exosomal lncRNA LOC101928697 in regulating endothelial function via FUS protein interaction in myocardial infarction.","authors":"Youfu He, Wei Liu, Yu Zhou, Liqiong Ai, Yu Qian, Xiaoxue Huang, Lei Peng","doi":"10.1177/00368504251372111","DOIUrl":"10.1177/00368504251372111","url":null,"abstract":"<p><p>ObjectiveType 1 myocardial infarction (T1MI) is primarily caused by the formation of coronary thrombi, which leads to acute myocardial ischemia and hypoxia and is associated with high morbidity and mortality rates. However, the effects of thrombus-derived exosomes (TEs) on endothelial cell function remain unclear. The aim of this study was to investigate the interaction between lncRNA LOC101928697, which is enriched in TEs, and FUS proteins, as well as their impact on endothelial cell function.MethodsThrombus-derived exosomes were extracted from thrombi collected from patients with T1MI, and lncRNAs with differential expression were identified through microarray analysis. Bioinformatic analyses were used to predict the interaction between LOC101928697 and FUS protein. The effects of TEs and LOC101928697 on human umbilical vein endothelial cells (HUVECs) were evaluated using CCK8 assays, scratch assays, cell cycle analysis, fluorescence <i>in situ</i> hybridization, and RT-PCR. The role of LOC101928697 was further confirmed by knockdown experiments.ResultsOur study indicates that TEs exert a significant inhibitory effect on the proliferation and migration of HUVECs, and that this effect is mediated by LOC101928697. LOC101928697 is highly enriched in TEs and has been shown to regulate the expression levels of CyclinD1 and PCNA by binding to FUS proteins, thereby inhibiting the proliferative capacity of endothelial cells. Furthermore, the inhibition of HUVEC proliferation and migration induced by TEs was significantly ameliorated by knockdown of LOC101928697.ConclusionThis study provides new insights into the mechanism by which TEs suppress endothelial cell function via the LOC101928697-FUS axis. These findings highlight a molecular target that may contribute to the progression of T1MI and provide a foundation for future research into diagnostic and therapeutic strategies for cardiovascular diseases.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251372111"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative evaluation of shear wave elastography and renal function biomarkers for predicting renal fibrosis in chronic kidney disease patients.","authors":"Jiexin Wang, Honglian Zhou, Xiaohong Xu, Yuping Yang, Qiang Huang, Shixing Zheng, Qiurong Ye","doi":"10.1177/00368504251363483","DOIUrl":"10.1177/00368504251363483","url":null,"abstract":"<p><p>ObjectiveWe hypothesize that combining point shear wave elastography (PSWE) with clinical risk factors enables accurate renal fibrosis assessment. This retrospective study integrates PSWE with serum creatinine (Scr) and estimated glomerular filtration rate (eGFR) to develop and validate a nomogram for personalized renal fibrosis evaluation in chronic kidney disease (CKD) patients.MethodsA total of 157 patients underwent renal PSWE and kidney biopsy. PSWE measured cortical stiffness in the mid-portion of the right kidney. Feature importance was selected using elastic net regression, XGBoost, and random forest, with PSWE, Scr, and eGFR identified as key variables. Three models were established: Model 1 (PSWE + Scr + eGFR), Model 2 (Scr + eGFR), and Model 3 (PSWE). Diagnostic performance was evaluated using receiver operating characteristic (ROC) curves and area under the curve (AUC) values. A nomogram based on PSWE, Scr, and eGFR was developed for precise fibrosis risk assessment. The Hosmer-Lemeshow test and K-fold cross-validation were used to evaluate the nomogram's generalizability.ResultsModel 1 achieved an AUC of 0.928, outperforming Model 2 (AUC = 0.878) and Model 3 (AUC = 0.824). The Hosmer-Lemeshow test yielded a <i>P</i>-value of .7969, and K-fold cross-validation showed an accuracy of 0.8419 and a Kappa value of 0.6780.ConclusionPSWE combined with Scr and eGFR enhances diagnostic accuracy in differentiating renal fibrosis severity in CKD patients, aiding clinicians in making precise clinical decisions. The PSWE-based nomogram demonstrates excellent performance in predicting renal fibrosis severity.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251363483"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and validation of mitochondrial ferroptosis and immune microenvironment-related hub biomarkers in liver cirrhosis by integrated bioinformatics analysis.","authors":"PengChao Deng, Ram Prasad Chaulagain, Babalola Deborah Oluwaseun, FeiYang Gao, JiaXin Wang, RanYan Gao, XinYu Jiang, FengChun Li, LingYi Xu, HaoXuan Xu, KaiXin Yao, Shizhu Jin","doi":"10.1177/00368504251380638","DOIUrl":"10.1177/00368504251380638","url":null,"abstract":"<p><p>BackgroundLiver cirrhosis represents a significant challenge to global public health. However, reliable biological markers for diagnosing liver cirrhosis are lacking in clinical practice.MethodsTranscriptome data from liver cirrhosis patients were acquired from the Gene Expression Omnibus database to identify coexpressed differentially expressed genes (DEGs). Mitochondria-related and ferroptosis-related genes were obtained from MitoCarta3.0 and FerrDB V2, respectively. Immune-related module genes were examined through Weighted Gene Co-Expression Network Analysis (WGCNA). By using WGCNA combined with machine learning methods, we identified immune-related biomarkers for liver cirrhosis. The immune cell infiltration was evaluated using CIBERSORTx, with core immune cell types further refined through LASSO regression and random forest. Hub biomarkers were validated using single-cell sequencing, with additional confirmation provided by histological staining and immunohistochemistry (IHC).ResultsThis study identified 2474 DEGs between liver cirrhosis and control groups. Intersection analysis with ferroptosis-related genes and mitochondria-related genes narrowed to 13 hub genes, from which machine learning selected 8 biomarkers. CIBERSORT and Wilcoxon tests revealed notable variations in the 12 immune cell types across the different groups. The WGCNA identified immune-related genes, with four immune-related biomarkers (<i>DHODH</i>, <i>FXN</i>, <i>CS</i>, and <i>ISCU</i>) identified as hub biomarkers. Integrated LASSO regression, random forest, and immune infiltration analyses pinpointed the core cells influencing disease progression. The relationship between the hub biomarkers and immune cells was validated by single-cell data analysis. <i>ISCU</i> expression was verified through IHC, consistent with our bioinformatics findings. Molecular docking identified three small molecules with potential effectiveness.ConclusionOur study identified mitochondrial ferroptosis-related genes (<i>DHODH, FXN, CS,</i> and <i>ISCU</i>) as pivotal biomarkers in liver cirrhosis progression and demonstrated a close connection with the immune microenvironment. These genes may serve as diagnostic indicators and therapeutic targets, thereby providing novel perspectives on the pathogenesis of liver cirrhosis.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251380638"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful endoscopic reduction of rare post-ESD colonic intussusception: A case report.","authors":"Shengyue Zhou, Zhiyi Chen, Yufei Hu","doi":"10.1177/00368504251375713","DOIUrl":"10.1177/00368504251375713","url":null,"abstract":"<p><p>Colonic intussusception after endoscopic submucosal dissection (ESD) is an uncommon, yet clinically significant complication. Therapeutic approaches for postoperative intussusception encompass conservative management, endoscopic reduction, and surgical intervention. We present a case involving a woman in her early 40s who experienced acute abdominal pain and fever shortly after ESD for a large ascending colonic adenoma. Contrast-enhanced computed tomography (CECT) of the abdomen confirmed intussusception without bowel ischemia. Immediate colonoscopic reduction was successfully performed, followed by conservative management. The patient achieved complete recovery with no recurrence at 3-month follow up. This case suggests that in patients developing post-ESD intussusception with no evidence of bowel necrosis or perforation, primary endoscopic intervention may be attempted and can be associated with favorable outcomes, potentially reducing the need for surgical management.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251375713"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructing and validating vision transformer-based assisted detection models for atrophic gastritis: A retrospective study.","authors":"Hu Chen, Shiyu Liu, Yanzi Miao, Xin Yang, Tao Li, Chuannan Wu, ZhenTao Li, Yahui Guo, Sijin Yu, Guangxia Chen","doi":"10.1177/00368504251381972","DOIUrl":"10.1177/00368504251381972","url":null,"abstract":"<p><p>ObjectiveTraining and validating vision transformer-based endoscopic assisted detection models for chronic atrophic gastritis (CAG) to assist endoscopists in detecting and localizing atrophic lesions.MethodsIn this retrospective study, gastroscopy images stored in the endoscopy center were collected between June 2019 and March 2023. On the basis of pathological findings, the images were manually classified into CAG and chronic nonatrophic gastritis (CNAG) using Labelme software, and the atrophic areas were further manually annotated in the CAG images. Furthermore, the anatomical structures were meticulously documented on the CNAG images. The labeled images were subsequently employed to train the Swin transformer and SSFormer for the task of detecting the anatomical structures of the stomach, CAG and atrophic lesion regions.ResultsThe test results revealed that the trained Swin transformer model had an accuracy of 0.98 in recognizing the anatomical structures of the stomach (gastric sinus, stomach angle, lesser curvature, cardia fundus, and greater curvature). Moreover, the accuracy, specificity, and sensitivity of the model in recognizing the CAG and CNAG images were 0.91, 0.95, and 0.86, respectively, which were significantly superior to those of the junior endoscopists who participated in the test (<i>p</i> < .05). In addition, the test results suggested that the trained SSFormer model had a similar ability to segment lesions as the senior endoscopist did, with the overlap of atrophic lesion regions indicated by both exceeding 0.90.ConclusionsIn this study, a set of vision models was trained to identify not only CAG and intragastric structures but also the extent of atrophy. The application of these models to the diagnosis of CAG is expected to increase the accuracy of this process.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251381972"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}