Science Progress最新文献

{"title":"Virtual screening combined with molecular docking for the !identification of new anti-adipogenic compounds.","authors":"Gilberto Mandujano-Lázaro, María F Torres-Rojas, Esther Ramírez-Moreno, Laurence A Marchat","doi":"10.1177/00368504251320313","DOIUrl":"10.1177/00368504251320313","url":null,"abstract":"<p><p>Obesity is an important risk factor for diabetes, cardiovascular diseases, and cancer, reducing the quality of life and expectancy of millions of people. Consequently, obesity has turned into one of the most health public problems worldwide, which highlights the urgent need for new and safe treatments. Obesity is mainly related to excessive fat accumulation; therefore, proteins participating in white adipose tissue increase and dysfunction are considered pertinent and attractive targets for developing new methods that can help with body weight control. In this context, virtual screening of libraries containing a large number of molecules represents a valuable strategy for the identification of potential anti-adipogenic compounds with reduced costs and time production. Here, we review the scientific literature about the prediction of new ligands of specific proteins through molecular docking and virtual screening of chemical libraries, with the aim of proposing new potential anti-adipogenic molecules. First, we present the targets related to adipogenesis and adipocyte functions that were selected for the following studies: PPARγ, Crif1, SIRT1, ERβ, PC1, FTO, Mss51, and FABP4. Then, we describe the obtention of new ligands according to the characteristics of the virtual screening approach, i.e. a structure-based drug design (SBDD) or a ligand-based drug design (LBDD). Finally, the critical analysis of these computational strategies and the corresponding results points out the necessity of combining computational and <i>in vitro</i> or <i>in vivo</i> assays for the identification of effective new anti-adipogenic molecules for obesity control. It also evidences that translating molecular docking and virtual screening results into successful drug candidates for adipogenesis and obesity control remains a huge challenge.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251320313"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue analysis of railway catenary dropper based on its stress incorporating displacement loading and fluctuating wind load.","authors":"Like Pan, Caizhi Yang, Xinxin Shen, Fan He, Xiaohan Zhu, Yingxin Zhao, Yuan Yuan, Qingyuan Zhao, Qingzhou Meng, Bo Dong, Xiaoli Guo","doi":"10.1177/00368504241311432","DOIUrl":"10.1177/00368504241311432","url":null,"abstract":"<p><p>In this paper, a simple chain suspension catenary model is constructed. The acting force of pantograph is reduced to a displacement loading. The stress and fatigue life of railway catenary dropper incorporating displacement loading and fluctuating wind load are studied. Through writing a MATLAB code, the vibration equation of the dropper is used to calculate its stress under different conditions using a finite difference method, combining with the initial boundary value conditions obtained by the response equations of the contact wire. Based on the dropper stress, its fatigue life can be obtained. The results show that under the 250 km/h train speed, the stress change process of the dropper experiences three stages: immediate rebound, attenuation vibration, and bending compression. Dropper Ⅳ is most likely to break in a span. Compared with dropper Ⅳ, the fatigue life of dropper Ⅰ is 11 times, and those of droppers Ⅱ, Ⅲ, and Ⅴ are about 2.5 times. Compared with no wind, the fatigue lives of droppers Ⅰ-Ⅳ are reduced by approximately three times at a wind speed of 25 m/s. This work provides a powerful means for the study of dropper stress under actual working condition.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241311432"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting nasal diseases based on microbiota relationship network.","authors":"Yibo Liang, Jie Mao, Tianlei Qiu, Binghua Li, Chenting Zhang, Kai Zhang, Zhe Sun, Guimin Zhang","doi":"10.1177/00368504251320832","DOIUrl":"10.1177/00368504251320832","url":null,"abstract":"<p><strong>Objectives: </strong>Increasing evidence indicates that the local microbiome can be used to predict host disease states. However, constructing models that obtain better results with fewer features is still challenging.</p><p><strong>Methods: </strong>In this study, we established a nasal microbiome database consisting of 132 chronic rhinosinusitis patients, 27 nasal inverted papilloma patients, and 45 control patients. 16S rRNA gene sequencing was used to identify the species and abundance of bacteria in each sample, and a nasal microbiome database was generated after low-abundance bacteria were eliminated. The correlation data network of different groups of bacteria was constructed by calculating the correlation coefficient among bacterial genera, and the correlation parameters of the network were calculated based on graph theory. Through the development and application of a machine learning framework to optimize the screening process, combined with microbiome relationship network parameters based on graph theory, basic bacteria with high contributions to classification prediction were selected for the prediction of nasal diseases.</p><p><strong>Results: </strong>We found that patients with nasal disease have a specific nasal microbiome signature and identified Moraxella, Prevotella, and Rothia as keystone genera that are markers of nasal disease; these markers can be interpreted as key control routes through graph theory analysis of the microbiota. With this strategy, we were able to characterize microbial community changes in nasal disease patients, which could reveal the potential role of the nasal microbiome in nasal disease.</p><p><strong>Conclusion: </strong>This study can provide a reference for the formulation of disease prevention and control policies. Our framework can be applied to other diseases to identify keystone genera that influence disease states and can be used to predict disease states.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251320832"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deterioration and improvement: The U-shaped impact of industrialization on agricultural carbon productivity in China.","authors":"Gui Zeng, Hana Wang","doi":"10.1177/00368504241302960","DOIUrl":"10.1177/00368504241302960","url":null,"abstract":"<p><p>Industry and agriculture are two major industries for a country's economic development and also important areas for promoting sustainable development. At present, most countries in the world have started the process of industrialization, and green agriculture is also valued by all countries. So what will be the impact of industrialization on the development of low-carbon agriculture? Studying this problem has a good theoretical and practical significance. To this end, we take the example of China's 2000-2021 provincial samples to study the impact of industrialization on agricultural carbon productivity. The study found that industrialization has a nonlinear effect on agricultural carbon productivity, with a significant U-shaped feature, i.e. first deteriorating and then improving. And there is obvious heterogeneity in this feature. The balance area of grain production and marketing and the main grain selling area are better than the main grain-producing areas, and the eastern and central regions are better than the western region. At the same time, in this process of influence, the level of economic development and urbanization has played a good role mechanism, while the transport infrastructure has played a positive regulatory effect.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241302960"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 on the prevalence of oral and maxillofacial disorders: A retrospective cohort study.","authors":"Bashar Abdullah, Omar Museedi, Noor Allawi, Fatimah J Ismael, Saman Warnakulasuriya","doi":"10.1177/00368504251326453","DOIUrl":"10.1177/00368504251326453","url":null,"abstract":"<p><p>ObjectiveThe COVID-19 pandemic has impacted various health conditions. Emerging evidence suggests that COVID-19 may trigger or exacerbate oral and maxillofacial conditions, yet data from Iraq and the broader Middle East remain limited. This retrospective cohort study, conducted at the Laboratory of Oral Pathology, College of Dentistry, University of Baghdad, explores potential links between COVID-19 infection and maxillofacial disorders.MethodsThis was a retrospective cohort study using data from the Laboratory of Oral Pathology, College of Dentistry, University of Baghdad. Cases were divided into pre-COVID-19 and post-COVID-19 periods. Chi-square tests assessed differences in oral pathologies incidence, while logistic regression analyzed associations with COVID-19 status and corticosteroid use.ResultsMucormycosis cases demonstrated a significant increase from 3 (pre-COVID-19) to 23 (post-COVID-19), with 65.22% of post-COVID-19 patients testing COVID-19-positive. A significant increase in mucormycosis severity was observed after COVID-19 (χ² = 14.24, p = 0.0026). Logistic regression identified age (coefficient 0.8738) as having a significant association with severe mucormycosis, while COVID-19 status (coefficient 0.1272) exerted a lesser effect. Sjögren's syndrome increased from 15 to 25 cases, with a model area under the curve of 0.8, indicating substantial ability to distinguish symptom changes pre- vs. post-COVID-19.ConclusionThe findings suggest that the pandemic has considerably impacted the incidence and severity of mucormycosis and Sjögren's syndrome. Older age and COVID-19 positivity may be key drivers of severe mucormycosis, whereas COVID-19 infection appeared to exacerbate Sjögren's syndrome symptoms. These results underscore the importance of vigilant monitoring and targeted therapeutic strategies for managing oral and maxillofacial conditions during and after viral pandemics.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251326453"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The synthesis and characterization of Various metal complexes of 2-(4-nitrophenyl)-1H-benzimidazole and its mono schiff base precursor.","authors":"Zoltán Köntös, Máté Bartek","doi":"10.1177/00368504251323767","DOIUrl":"10.1177/00368504251323767","url":null,"abstract":"<p><p>The synthesis and application of metal complexes of 2-(4-nitrophenyl)-1H-benzimidazole, a significant heterocyclic compound, are rooted in the formation of its mono Schiff base precursor, N-(4-nitrobenzyl) benzene-1,2-diamine. This precursor is synthesized via the condensation of o-phenylenediamine (OPD) with 4-nitrobenzaldehyde (NBA). The formation of the Schiff base involves the nucleophilic attack of OPD's amino groups on the carbonyl carbon of 4-nitrobenzaldehyde, resulting in an imine linkage essential for subsequent cyclization reactions. Cyclization of the mono Schiff base N-(4-nitrobenzyl) benzene-1,2-diamine (NBD) is a crucial step in forming the benzimidazole ring. This compound's significance lies in its structural and electronic properties, influenced by the electron-withdrawing nitro group, making it valuable in coordination chemistry, medicinal chemistry, and materials science. In coordination chemistry, metal complexes of 2-(4-nitrophenyl)-1H-benzimidazole (NBI) acts as a ligand, forming stable complexes with transition metals that exhibit enhanced catalytic activity. These metal complexes are essential for various catalytic processes, including organic transformations and polymerization reactions. In medicinal chemistry, the benzimidazole core is a common motif in biologically active compounds. The presence of the nitro group can modulate the biological activity, making derivatives of 2-(4-nitrophenyl)-1H-benzimidazole (NBI) promising candidates for antimicrobial, anticancer, and antiviral agents. Research has also highlighted the applications of Schiff bases and their metal complexes in various fields. Schiff bases serve as versatile intermediates in the synthesis of heterocyclic compounds, while their metal complexes are explored for their catalytic, antimicrobial, and anticancer properties. The synthesis of 2-(4-nitrophenyl)-1H-benzimidazole and its derivatives remains a topic of significant interest due to their potential in developing new materials and pharmaceuticals. The synthesis of metal complexes of 2-(4-nitrophenyl)-1H-benzimidazole from its Schiff base precursor is a critical process with wide-ranging applications in coordination chemistry, medicinal chemistry, and materials science. The optimization of reaction conditions and the exploration of the compound's properties continue to drive research in this area, highlighting its importance in both fundamental and applied sciences.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251323767"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of the CDCA gene family in breast carcinoma.","authors":"Wei Ding, Wei Han, Chun-Tao Shi, Li-Qian Yao, Zhi-Wei Liang, Ming-Hui Zhou, Hao-Nan Wang","doi":"10.1177/00368504241312305","DOIUrl":"10.1177/00368504241312305","url":null,"abstract":"<p><p>Cell division cycle-associated (CDCA) genes are dysregulated in carcinomas. Our study aims to identify similarities and differences of the clinical roles of CDCAs in breast cancer (BRCA) and to explore their potential mechanisms. In GEPIA, compared to normal tissues, expressions of CDCAs were higher in BRCA and sub-types. In addition, CDCAs were significantly positively related to stages and predicted worse survival in BRCA. In CancerSEA, expression levels of most CDCAs were strongly positively related to cell cycle, DNA damage, DNA repair, and proliferation. In TIMER, CDCAs were linked with immune infiltration levels of BRCA, including Dendritic cell, B cell and so on, and were positively related to most of the common markers of immune cells, especially CD38 of B cell and IL12RB2 of Th1. In GeneMANIA, there were complex interactions and co-expression relationships between CDCAs and cell division-associated genes. In addition, CDCA1, CDCA3, CDCA5, CDCA6 and CDCA8 had a high proportion of amplification in BRCA, and CDCA1, CDCA2, CDCA5, CDCA7 and CDCA8 had high levels of body DNA methylation. Among 11 transcription factors possibly combining promoters of all CDCAs, FOXP3 and YY1 were significantly higher in BRCA in comparison to normal tissues, and both had a positive relationship with all CDCAs in GEPIA and IHC. In addition, silencing FOXP3 or YY1 decreased levels of CDCAs in MDA-MB-231. In summary, CDCAs have various similarities in clinical functions, functional states, immune infiltration, and mechanisms, and they may become novel potential biomarkers for BRCA.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241312305"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automating container damage detection with the YOLO-NAS deep learning model.","authors":"Thanh Nguyen Thi Phuong, Gyu Sung Cho, Indranath Chatterjee","doi":"10.1177/00368504251314084","DOIUrl":"10.1177/00368504251314084","url":null,"abstract":"<p><p>Ensuring the integrity of shipping containers is crucial for maintaining product quality, logistics efficiency, and safety in the global supply chain. Damaged containers can lead to significant economic losses, delays, and safety hazards. Traditionally, container inspections have been manual, which are labor-intensive, time-consuming, and error-prone, especially in busy port environments. This study introduces an automated solution using the YOLO-NAS model, a cutting-edge deep learning architecture known for its adaptability, computational efficiency, and high accuracy in object detection tasks. Our research is among the first to apply YOLO-NAS to container damage detection, addressing the complex conditions of seaports and optimizing for high-speed, high-accuracy performance essential for port logistics. Our method showcases YOLO-NAS's superior efficacy in detecting container damage, achieving a mean average precision (mAP) of 91.2%, a precision rate of 92.4%, and a recall of 84.1%. Comparative analyses indicate that YOLO-NAS consistently outperforms other leading models like YOLOv8 and Roboflow 3.0, which showed lower mAP, precision, and recall values under similar conditions. Additionally, while models such as Fmask-RCNN and MobileNetV2 exhibit high training accuracy, they lack the real-time assessment capabilities critical for port applications, making YOLO-NAS a more suitable choice. The successful integration of YOLO-NAS for automated container damage detection has significant implications for the logistics industry, enhancing port operations with reliable, real-time inspection solutions that can seamlessly integrate into predictive maintenance and monitoring systems. This approach reduces operational costs, improves safety, and lessens the reliance on manual inspections, contributing to the development of \"smart ports\" with higher efficiency and sustainability in container management.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251314084"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A backtracking heuristic algorithm for two-dimensional strip packing with rotation.","authors":"Li Li, Baoguo Liu, Zhaoyun Wu","doi":"10.1177/00368504241301530","DOIUrl":"10.1177/00368504241301530","url":null,"abstract":"<p><p>A backtracking heuristic algorithm (BHA) was proposed for a two-dimensional rectangular strip packing problem with rotations and without guillotine cutting, which has many applications. An improved fitness strategy was used to select the fittest rectangle to be packed on a strip with a certain height. Next, a backtracking constructive heuristic was repeatedly used at a higher height until all the rectangles were packed. A multi-start improvement procedure then found the best solution by taking a different rectangle as the first rectangle, whereas the sequence of the other rectangles remained unchanged. Finally, in order to further expand the scope of the solution, a simple randomized local search procedure based on random sequences of rectangles with the first rectangle unchanged was applied to search for the optimal solution. BHA has only two parameters; it is simple and effective. Computational results on benchmark problems (zero-waste instances and non-zero-waste instances) with different scales (from 10 to 75,032 rectangles) indicate the following: (1) though it is non-deterministic, the difference between the results after each running is tiny and (2) the proposed algorithm outperforms most of the other algorithms under comparison on the whole, especially for large-scale instances with more than 1000 rectangles, which is further verified by statistical analysis and greatly meaningful in mass industrial production like metal cutting.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241301530"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of peak D-dimer in predicting mortality and venous thromboembolism in COVID-19 patients.","authors":"Rachel H Lee, Shan Wang, Meredith Akerman, D'Andrea Joseph","doi":"10.1177/00368504241247982","DOIUrl":"10.1177/00368504241247982","url":null,"abstract":"<p><p>Covid 19 patients often present with elevated D-dimer levels. The purpose of this study is to evaluate the role of D-Dimer levels in Covid 19 patients to predict mortality and venous thromboembolism (VTE) events. This is a retrospective chart review study from 1 April 2020 to 30 June 2020, during the peak Covid pandemic. A total of 350 patients were enrolled in this study; 69 (19.7%) patients died; 12 (3.4%) had a deep venous thrombosis; and 8 (2.3%) had a pulmonary embolism outcome. Peak D-dimer levels were collected with median levels of 765 ng/ml (266, 3135). Patients with VTE outcomes had significantly higher levels of peak D-dimers than patients in the non-VTE group (4876 vs 680, <i>p</i> < 0.0001). Patients who died had higher peak D-dimer levels than those who survived (4690 vs 501, <i>p</i> < 0.0001). The optimal cutoff point in peak D-dimer in predicting VTE events was 1437, yielding a sensitivity of 84.2% and a specificity of 65.0%. The optimal cutoff point in peak D-dimer in predicting mortality was 2004, yielding a sensitivity of 71.0% and a specificity of 77.9%. This study suggests that D-dimer levels can be elevated in Covid 19 hospitalized patients and can serve as indicators for mortality and VTE events.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241247982"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}