Science Progress最新文献

{"title":"Association between frailty and the risk of allergic rhinitis: Evidence from a nationwide cross-sectional study.","authors":"Lin Wang, Longgang Yu, Jisheng Zhang, Xudong Yan, Yan Jiang, Han Chen","doi":"10.1177/00368504251381587","DOIUrl":"https://doi.org/10.1177/00368504251381587","url":null,"abstract":"<p><p>ObjectiveAllergic rhinitis (AR) is a common inflammatory condition that affects quality of life. Frailty, a syndrome of reduced physiological reserves, has been linked to various chronic diseases, but its association with AR remains unclear. This study aimed to explore the relationship between frailty and AR in a large-scale, population-based cohort.MethodsIn this retrospective cross-sectional study, 24,269 participants from the Korea National Health and Nutrition Examination Survey were categorized into AR and non-AR groups based on self-reported history. Frailty was assessed using the modified frailty phenotype (FP) and frailty index (FI). Multivariate logistic regression analysis was used to assess the association, with subgroup analyses performed by demographic and clinical factors.ResultsFrailty measured by FP (OR = 1.251, 95% CI [1.060, 1.476]) and FI (OR: 1.587, 95% CI [1.116, 2.257]) was associated with an increased risk of AR, particularly pronounced in males (OR = 1.516, 95% CI [1.134, 2.027]), younger (OR = 1.298, 95% CI [1.022, 1.648]) and middle-aged adults (OR = 1.372, 95% CI [1.024, 1.838]), individuals with a high school education (OR = 1.482, 95% CI [1.135, 1.934]), those with a body mass index ≥ 25 (OR = 1.823, 95% CI [1.388, 2.395]), and white-collar workers (OR = 1.361, 95% CI [1.051, 1.761]), and those with higher family income (OR = 1.433, 95% CI [1.072, 1.914]), a history of smoking (OR = 1.265, 95% CI [1.040, 1.535]), and frequent alcohol consumption (OR = 1.578, 95% CI [1.091, 2.282]). Further analysis indicated that the heightened risk of AR associated with frailty may be attributed to increased levels of emotional exhaustion (OR: 1.334, 95% CI [1.178, 1.510]).ConclusionsFrailty is independently associated with a higher prevalence of AR, highlighting the need for comprehensive management strategies addressing both physical and mental health in AR patients.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251381587"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper endoscopy in Solomon Islands: A four-year retrospective study.","authors":"Dylan M Bush, Stallone Kohia, Adrian Garcia Hernandez, Scott Siota, Elizabeth Wore, Rooney Jagilly, Augustin Melly, Peter H Katelaris, Mark W Norrie, Alexandra Lc Martiniuk, Steven F Moss","doi":"10.1177/00368504251355383","DOIUrl":"10.1177/00368504251355383","url":null,"abstract":"<p><p>ObjectiveGastrointestinal diseases are common, yet some countries still lack endoscopy. Modern flexible endoscopy was introduced to the Solomon Islands National Referral Hospital (NRH) in 2012, but little is known about gastrointestinal disease in the country.MethodsThis retrospective cohort study describes trends in upper gastrointestinal diseases to inform local research and health programming. Demographic, clinical, and endoscopic data, including rapid urease test (RUT) results for <i>H. pylori</i>, were abstracted from consecutively entered patient medical records at the NRH.ResultsA total of 761 patients underwent upper endoscopy and RUT (2019-2022). Although RUT was positive in only 25.8% of patients (<i>N</i> = 196), relatively common findings of erosions (<i>N</i> = 90, 11.8%) and ulcers (<i>N</i> = 89, 11.7%), as well as frequently reported symptoms of upper gastrointestinal bleeding (<i>N</i> = 168, 22.1%), suggest a higher true prevalence of <i>H. pylori</i>-associated peptic ulcer disease in this cohort. Age was associated with an endoscopic finding of ulcers on univariate analysis. Multivariable modeling indicated a significant association between the presence of gastric erythema and erosions and the diagnosis of duodenitis. Multivariable regression also showed symptoms of melena and hematemesis to be significantly associated with the endoscopic finding of ulcers. Among patients treated for <i>H. pylori</i> who underwent follow-up endoscopy and RUT, 28.8% failed treatment.ConclusionThere was a high degree of concern regarding gastrointestinal symptomology and pathology in this cohort. Access to endoscopy and RUT in Solomon Islands remains limited to a single endoscopy unit. Future efforts should explore non-invasive clinical pathways for the expansion of RUT and the management of ulcer disease in Solomon Islands.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251355383"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear implantation in children with Bartter syndrome: A case report.","authors":"Khalid M Badr, Syed A Raza, Asma Alahmadi, Fares Alghamdi, Alsaeid M Thabet, Saeed Alghamdi","doi":"10.1177/00368504251349390","DOIUrl":"10.1177/00368504251349390","url":null,"abstract":"<p><p>Bartter syndrome (BS) is an autosomal recessive disorder characterized by polyhydramnios, premature birth, polyuria, renal salt-wasting, hypokalemic metabolic alkalosis, normal blood pressure with increased levels of renin and aldosterone, and the presence of hearing loss. Mutations in BSND, CLCNKA, and CLCNKB cause the disorder. We present a 3-year-old girl with BS type 4 and sensorineural hearing loss who received cochlear implantation (CI) after failing a hearing screening. The patient had a successful left-side implantation but later developed a flap infection, initially treated with antibiotics and surgical repair using a vascularized flap, which failed. During the same repair procedure, the right ear was implanted successfully. A third surgery was required to remove the left implant and close the wound with a temporoparietal flap, performed by plastic surgery. This is the earliest report on managing device extrusion in BS. The literature review highlights that the outcomes of CI in patients with BS vary significantly within each syndrome group and that the presence of additional disabilities accentuates this diversity. Our case illustrates that CI can improve the quality of life for patients with BS, but a multidisciplinary team is crucial for managing these cases. We stress the need for further studies to evaluate realistic outcomes and complication rates, as this will guide future treatment strategies.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251349390"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A stage IV high-grade serous ovarian cancer patient carrying <i>ERBB2</i> amplification and ERBB2 overexpression benefits from late-line pyrotinib treatment: A case report.","authors":"Baorang Zhu, Ying Liu, Jing Li, Wuwei Yang","doi":"10.1177/00368504251362310","DOIUrl":"10.1177/00368504251362310","url":null,"abstract":"<p><p>Ovarian cancer (OC), one of the most common gynecological cancers, is usually diagnosed at an advanced stage. High-grade serous ovarian cancer (HGSOC) is a histological subtype of OC that accounts for approximately 70% of all OC cases. erb-b2 receptor tyrosine kinase 2 (ERBB2) overexpression commonly occurs in HGSOC, accounting for 12.5% of stage III and IV HGSOCs. Currently, there is no established treatment strategy for OC patients with <i>ERBB2</i> amplification or ERBB2 overexpression. Whether these patients will benefit from ERBB2 inhibitors remains unclear. Herein, we report a patient with metastatic HGSOC carrying <i>ERBB2</i> amplification and ERBB2 overexpression. Following progression to platinum-based chemotherapy and subsequent antiangiogenic therapies, the patient benefited from late-line pyrotinib treatment, achieving stable disease with a progression-free survival of 9.5 months. Our study provides preliminary clinical evidence supporting pyrotinib as a feasible treatment option for metastatic HGSOC patients with <i>ERBB2</i> amplification and/or ERBB2 overexpression. Prospective trials of pyrotinib should be conducted in appropriately selected OC populations.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251362310"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of recovered vanadium pentoxide solution from a spent vanadium catalyst as an efficient electrolyte in an electric storage battery.","authors":"Hiba H Al Amayreh, Majd I Hawwari, Mohammed K Hourani, Abeer Al Bawab","doi":"10.1177/00368504251366849","DOIUrl":"10.1177/00368504251366849","url":null,"abstract":"<p><p>ObjectiveThe present investigation aims to utilize the extract of vanadium pentoxide from spent vanadium catalyst in a tabletop vanadium redox flow battery (VRFB) and a home-designed cell stack. The most commonly used redox couples in VRFB systems are V²⁺/V³⁺ and V⁴⁺/V⁵⁺ which typically require the use of costly VOSO₄ standard solution. In this study we propose an alternatve approch by substituting these expensive solutions with more affordable and environmentally friendly option: a V₂O₅ solution derived from spent catalyst.MethodCharacterization of the recovered vanadium solutions, incorporation of these solutions were performed in a three electrode cell and in a real bench-top vanadium storage battery model, and the performance of the constructed battery was tested using different electrochemical techniques such as cyclic voltammetry.ResultThe increasing current and potential observed were proportional to the concentration of the recovered solution. Furthermore, an in-house tabletop VRFB utilizing the recovered electrolyte exhibited promising electrochemical properties, achieving a maximum discharge potential of 2.0 V after 180 minutes of electrical charging and a maximum current of 83.5 mA. These results are encouraging for the utilization of recovered vanadium solutions in VRFBs.ConclusionThis study results are encouraging for the utilization of recovered vanadium solutions in VRFBs. This work suggests a novel technique that utilizes waste vanadium solutions from the sulfuric acid industry for sustainable VRFB applications.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251366849"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing systems in squad athletes: Where otology meets sports medicine.","authors":"Julia Kristin, Katharina Schaumann, Kim Lennartz, Miriam Simon, Marcel Dudda, Bastian Mester, Manuel Burggraf","doi":"10.1177/00368504251372793","DOIUrl":"10.1177/00368504251372793","url":null,"abstract":"<p><p><b>Objective:</b> Deaf and hard-of-hearing athletes represent a unique population in elite sports. While hearing loss does not inherently impair athletic performance, it can affect communication, safety, and injury risk. To date, little is known about the use and perceived benefit of hearing systems among elite deaf athletes. This study aimed to evaluate hearing status, the use of hearing aids or cochlear implants (CIs), and the impact of hearing systems on communication and injury incidence in elite deaf athletes in Germany. <b>Methods:</b> A self-developed, web-based questionnaire (127 items) was distributed to all athletes (<i>n</i> = 170) in the German Deaf Sports Association elite squad. A total of 54 athletes (12 females, 42 males; mean age of 28.8 ± 10.5 years) completed the survey. Statistical analyses were performed using SPSS. <b>Results:</b> The most frequently utilized hearing devices are hearing aids (72.1%) and CIs (32.6%). In total, 75% wore their devices during training with hearing athletes, but only 25% did so when training with deaf athletes. In competitions for deaf athletes, hearing devices are prohibited. All users reported improved communication in everyday life, with 90% perceiving a clear communication advantage in sports. Athletes who do not use hearing devices seem to have a significantly higher number of work-related incapacities due to sports injuries. <b>Conclusion:</b> Hearing aids and CIs are perceived as beneficial, particularly in communication and potentially in injury prevention. These findings highlight the importance of supporting and optimizing the use of hearing devices in sports to enhance athlete safety, communication, and performance.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251372793"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative lipid levels and prognosis in non-small cell lung cancer: A retrospective age-stratified study.","authors":"Yv-Xuan Liu, Jing Chen, Chen Liu, Maierhaba Maitiyasen, Xinyv Hou, Jingfeng Li, Jun Yi","doi":"10.1177/00368504251352375","DOIUrl":"10.1177/00368504251352375","url":null,"abstract":"<p><p>BackgroundAlthough abnormalities in circulating lipids and lipoproteins are associated with increased cancer risk, their specific impact on lung cancer progression and prognosis is still unclear. This study retrospectively assessed the influence of preoperative lipid and lipoprotein levels on non-small cell lung cancer progression and prognosis, stratified by age.MethodsIn this retrospective study, we analyzed 849 patients to investigate the association between lipid markers and lung cancer progression, and examined postoperative prognosis in a subset of 222 patients. Data was analyzed using restricted cubic spline curves, Kaplan-Meier survival analysis, and Cox proportional hazards models.ResultsA significant nonlinear relationship was observed between total cholesterol (TC), high-density lipoprotein (HDL), ApoB, ApoAI, ApoE, and baseline tumor diameter (BSLD) (PTC = 0.025; PHDL < 0.001; PApoB = 0.037; PApoAI =0.001; PApoE < 0.001). In contrast, Lp(a) showed a significant linear relationship with BSLD (P = 0.002). The Cox regression analysis revealed that triglyceride (TG) (hazard ratio (HR) = 0.50, 95% confidence interval (CI): 0.28-0.92, P = 0.025) was significantly negatively associated with lung cancer mortality in patients under 58 years. For patients over 58 years, higher ApoB levels were linked to a reduced risk of lung cancer death (HR = 0.59, 95% CI: 0.36-0.97, P = 0.038).ConclusionThis study reveals a significant negative correlation between ApoAI and HDL levels with BSLD, while Lp(a) shows a positive correlation. In terms of long-term prognosis, high-serum ApoB are associated with a lower mortality risk in all lung cancer patients, and high-serum TG levels associated with reduced mortality risk in patients aged under 58 while high-serum TC levels associated with reduced mortality risk in patients over 58, with high Lp(a) levels indicating a greater risk of mortality in older patients.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251352375"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive model of double-J pipe scab size after radical total cystectomy based on Boruta feature selection and LASSO technique: A retrospective cross-sectional study.","authors":"Cheng Shen, Haishun Ni, Zhan Chen, Junjie You, Bing Zheng","doi":"10.1177/00368504251363901","DOIUrl":"10.1177/00368504251363901","url":null,"abstract":"<p><p>ObjectiveThis study sought to develop a prediction model for double-J pipe scab following radical total cystectomy.MethodsThis retrospective study included clinical data on 175 patients who underwent routine double-J pipe replacement after radical total cystectomy. A double-J pipe scab was the nomogram's outcome. Boruta feature selection and the least absolute shrinkage selection operator (LASSO) approach were employed to predictions as efficiently as possible. Using multiple logistic regression, predictive models were created and displayed as nomograms. Nomogram performance was assessed using decision curve analysis, calibration plots, and receiver operating characteristic (ROC) curves. By computing the validation cohort's performance, the model was internally validated.ResultsThis study covered 175 patients in total. In twenty-nine individuals (16.57%), a double-J pipe scab formed. Every participant was randomly split into two groups: training (<i>n</i> = 122) and validation (<i>n</i> = 53). As predictors, this nomogram included urine leukocytes, urinary PH, daily water intake, BMI, and double-J pipe brand. Excellent identification performance is indicated by the training and verification groups' ROC curves, while the calibration curves demonstrate both groups' excellent correction outcomes.ConclusionThis study establishes a foundation for preventing and treating double-J pipe stones. It has a substantial predictive value for the occurrence of double-J pipe stones in the double-J pipe following radical total cystectomy.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251363901"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balloon-assisted ExoSeal closure for inadvertent subclavian artery cannulation following central venous catheterization: A case report.","authors":"Yu Wang, Tao Liu, Xuemei Zhou, Fa-Cai Guo","doi":"10.1177/00368504251363121","DOIUrl":"10.1177/00368504251363121","url":null,"abstract":"<p><p>Accidental arterial puncture is a rare but significant complication associated with central venous catheterization. This report describes a case of inadvertent subclavian artery catheterization that was successfully managed with the ExoSeal vascular closure device. A female patient in her early 30s was hospitalized for severe acute pancreatitis that necessitated cannulation of the right subclavian vein. Postprocedure, infusion difficulties suggested a need for arterial catheterization, which was confirmed by imaging. The intervention resulted in prompt hemostasis and prevented further vascular injury, resulting in complication-free recovery. This case highlights the importance of rapid identification and treatment of arterial injury during central venous catheterization, and also demonstrates the effectiveness of ExoSeal in the management of vascular complications, especially in high-risk conditions.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251363121"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome analysis of peach seedlings (<i>Prunus davidiana</i>) experiencing drought stress.","authors":"Ruijin Zhou, Baoquan Wang, Qianwen Liu, Shuda Li, Lulu Zhang","doi":"10.1177/00368504251358640","DOIUrl":"10.1177/00368504251358640","url":null,"abstract":"<p><p>The frequency of drought is expected to rise in many parts of the world with increasing climate change. Despite being an economically valuable plant species, the molecular mechanisms regulating the responses of peach (<i>Prunus davidiana</i>) to drought stress and the functional genes conferring drought resistance are currently unknown. In this study, we investigated the phenotypic and physiological responses of peach seedlings to experimental conditions that included a control, a period of drought stress, and a rehydration period. We performed transcriptome sequencing and investigated differences in the transcriptome of peach seedlings exposed to different treatments. We also analyzed the functions and regulatory pathways of differentially expressed genes using GO and KEGG enrichment. The results showed that severe drought stress occurred in the peach seedlings on the sixth day of drought, and that the physiological responses of peach seedlings experiencing drought stress were significantly different from those in control conditions. We found 21348 differentially expressed genes in peach seedlings under drought stress, of which 10105 were up-regulated and 11243 were down-regulated in comparison with peach seedlings in control conditions. These differentially expressed genes were mainly involved in the biosynthesis of amino acids, metabolic pathways, antioxidant defense systems and the plant hormone signal transduction system. The results suggest that peach seedlings respond to severe drought stress by initiating antioxidant defense mechanisms to alleviate damages, activating different signal transduction pathways to transmit signals, regulating the synthesis of amino acids, and initiating metabolic mechanisms to enhance osmotic pressure. This study illuminates the mechanisms for drought resistance in peach seedlings at the molecular level. Overall, the findings provide a theoretical basis for the cloning and functional analysis of genes conferring drought resistance, and the cultivation of more drought resistant varieties of peach.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251358640"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12319264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}