Science Progress最新文献

{"title":"The combination of immune checkpoint inhibitor and chemotherapy may be efficacious for advanced non-small cell lung cancer with near-loop insertions of <i>EGFR</i> exon 20: A retrospective analysis.","authors":"Ke-Jun Liu, Hong-Rui Li, Quan-Quan Tan, Tao Jiang, Kai-Cheng Peng, Hua-Jun Chen, Qing Zhou, Xu-Chao Zhang, Zheng Zheng, Shi-Yuan Chen, Xue Zheng, Hong-Bo Zheng, Bei-Bei Mao, Long-Long Gong, Xian-Wen Chen, Wendy Wu, Yi-Long Wu, Jun Jia, Jin-Ji Yang","doi":"10.1177/00368504251325406","DOIUrl":"10.1177/00368504251325406","url":null,"abstract":"<p><p>ObjectiveThe sensitivity of immune checkpoint inhibitors (ICIs) as monotherapy is low in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (<i>EGFR</i>) exon 20 insertion mutations (ex20ins). This study aims at investigating the effectiveness of the combination of ICI and chemotherapy (ICI-combined regimen) in a real-world population of NSCLC patients harboring near-loop insertions of <i>EGFR</i> exon 20.MethodsWe conducted a retrospective study of advanced NSCLC with <i>EGFR</i> ex20ins from April 2016 to March 2021 at Guangdong Provincial People's Hospital, Southern Medical University, China. A total of 126 cases of <i>EGFR</i> ex20ins were screened from 1610 patients with advanced NSCLC harboring <i>EGFR</i> mutations and 62 cases were further analyzed for different therapeutic efficacy.ResultsThe first-line ICI-combined regimen showed marked efficacy for near-loop insertions of <i>EGFR</i> exon 20, with an ORR of 71.4% and a mPFS of 11.5 months, compared to ORRs of 12.5% for traditional targeted therapy (<i>P </i>= .003) and 18.8% for chemotherapy (<i>P </i>= .013). The first-line mPFS of traditional <i>EGFR</i>-TKIs and chemotherapy were only 5.6 and 5.8 months, respectively. Similar results were observed for any-line therapy of ICI-combined regimen, with an ORR of 80%. The median progression-free survival (PFS) of any-line therapy of ICI-combined regimen was 11.5 months, which were significantly longer than that of traditional targeted therapy (4.5 months, <i>P </i>= .026) and chemotherapy (5.0 months, <i>P </i>= .013).ConclusionsICI-combined regimen may be superior compared to targeted therapy and chemotherapy for advanced NSCLC with near-loop insertions of <i>EGFR</i> exon 20. Further exploration is warranted to confirm the efficacy of ICI-combined regimen.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251325406"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From trade to green: How cross-border e-commerce drives green technology inventions in enterprises.","authors":"Chunhai Tao, Chengyi Zhan","doi":"10.1177/00368504251330709","DOIUrl":"10.1177/00368504251330709","url":null,"abstract":"<p><p>Cross-border e-commerce (CBEC) represents a digitized form of international business that provides enterprises with an opportunity to enhance their innovation of green technologies. This paper explores the impact of CBEC on the green technological innovations (GTIs) among enterprises by examining China's CBEC Pilot Zone as a quasi-natural experiment. We employ panel data from China's A-share listed companies covering the period from 2011 to 2022 and implement a staggered difference-in-differences model for our analysis. The results of the study indicate that CBEC fosters the GTI and enhances both the quantity and percentage of green patents held by enterprises. These results remain robust after robustness tests and account for the effects of heterogeneity treatment. Heterogeneity analysis shows that this positive effect is particularly pronounced among large firms, non-state-owned firms, highly polluting industries, and firms in inland areas. Mechanism studies demonstrate that alleviating financial constraints and enhancing absorptive capacity are two crucial channels through which CBEC fosters GTI in firms. Notably, absorptive capacity significantly moderates the firm's information advantage, amplifying the effectiveness of this process.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251330709"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depositional model of the fan delta of thick glutenite: Example from the Linhe Depression, Hetao Basin, China.","authors":"Xiaofan Hao, Xuesong Yang, Bin Cao, Huilai Wang, Chenlin Wu, Chenya Li, Lin Qu, Jiye Li, Yongli Pan, Xiao Hu","doi":"10.1177/00368504251326867","DOIUrl":"10.1177/00368504251326867","url":null,"abstract":"<p><p>The thick glutenite formed in the Linhe Depression of the Hetao Basin during the Early Cretaceous offers notable exploration potential. However, the sediment comprises a rapidly stacked succession of glutenite featuring poor sortability, with the individual sedimentary layers reaching up to 120 m in thickness. However, the limited core variations coupled with the \"dentate box\" shape of the well logging curves pose challenges in identifying the sedimentary microfacies of the study area, thereby hindering its exploration and development. This study selected the Jihua-2 block in the Linhe Depression as the study area and attempted to identify the sedimentary microfacies in the thick glutenite formed in this region. Results indicate that under arid and shallow-water conditions, the Langshan Fault continued to move, and a set of thick-bedded glutenite masses was deposited in the downthrown block. Detailed core observations revealed seven lithofacies and five lithofacies combinations. The study area is mainly characterized by a fan-delta front, which is further subdivided into the main part of underwater distributary channels, lateral margins of underwater distributary channels, and interdistributary bays. By integrating probabilistic distribution statistics with single well analysis, a quantitative standard for identifying well logging facies based on cored wells was established. Kriging interpolation was performed to clarify the spatial distribution of the sedimentary microfacies across the study area, enabling the establishment of a depositional model of fan-delta facies for the study area. The influence of faults on sedimentary facies and the relation between depositional patterns and hydrocarbon distribution in the study area were also discussed. The findings of this study can contribute to the development of improved methods for identifying sedimentary microfacies in glutenite fan deltas, with implications for guiding exploration and development.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251326867"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of indoor parking lot planning for electric vehicles through fire dynamics simulation.","authors":"Yuan-Ming Chiu, Chih-Yuan Weng, Yu-Jen Chen","doi":"10.1177/00368504251331877","DOIUrl":"10.1177/00368504251331877","url":null,"abstract":"<p><p>The lack of clear regulations regarding the provision of electric vehicles parking lots, particularly in indoor parking lots, may result in inadequate fire protection and contingency planning during construction. This study investigated fire contingency planning for electric vehicle parking lots in large shopping mall, specifically scrutinizing the effects of charging pile locations, and was conducted through field research and computer simulations. Fire dynamic simulation model was utilized to simulate a fire in an indoor parking lot and investigate the impact of automatic sprinkler systems on the fire scene. The findings indicated that while automatic sprinkler cannot directly extinguish a fire, they can suppress the hazard parameters of the surrounding environment, alleviate the hazard area, and provide more time for responders or firefighters to rescue those affected.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251331877"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetic estimated glomerular filtration rate and drug dosing in critically ill patients with acute kidney injury-A prospective observational study.","authors":"Divya Dinakar, Garud Chandan, Rajanna Sreedhara, Aashish Parekh, Padmakumar Aryamparambil, Pooja ikPrathapan Sarada, Ganesh Km","doi":"10.1177/00368504251315806","DOIUrl":"10.1177/00368504251315806","url":null,"abstract":"<p><strong>Objective: </strong>To study the impact of kinetic glomerular filtration rate (kGFR) on clinical decision making and its implications on drug dosing compared to that of estimated GFR (eGFR) using chronic kidney disease epidemiology collaboration (CKD-EPI) equation in critically ill patients with acute kidney injury (AKI) admitted in a tertiary level intensive care unit (ICU).</p><p><strong>Methods: </strong>Cross-sectional, prospective, observational study design. All patients admitted to Medical ICU, Fortis Hospital, Bangalore with AKI defined as per AKI network (AKIN) criteria. Patients were recruited after approval from the scientific and institutional ethics committee, with written informed consent. Serum creatinine values at admission and further values were noted. GFR was calculated using both formulas (CKD-EPI and kGFR) and documented at all intervals of creatinine sampling. Drugs requiring renal dose modification along with the dosing were documented. Sample size was calculated after a pilot study and a total of 107 patients were analyzed.</p><p><strong>Results: </strong>Incidence of AKI was 12.84%. The mean (±SD) eGFR was 37.25 (±29.4) and kGFR was 42.5 (±33.2), (<i>p</i>-value .003). 70 (65.42%) patients required drug dose change when kGFR was used. Dosing changes from Day 1 to Day 5 are 53/104 (50.9%), 39/81 (48.1%), 12/26 (46.1%), 2/9 (28.5%), 1/2 (50%). Predominant dose changes were for antimicrobials: vancomycin (35.7%), acyclovir (23.1%), and meropenem (23%).</p><p><strong>Discussion: </strong>Drug dosing using different methods of GFR calculation showed a difference in the dosing in 65.42% of patients with AKI. Accounting for change in creatinine over time using kinetic GFR may lead to better drug dosing in critically ill patients with AKI.</p><p><strong>Conclusion: </strong>Our study shows that calculating GFR using kGFR formula instead of CKD-EPI may change drug dosages among patients with AKI admitted in ICU. By replacing conventional GFR estimation formulas with kGFR we may reduce the drug dosing inaccuracies that are currently prevalent in this cohort of patients.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251315806"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex striate-frontal projection and specific frontal gyrus dysfunctions concern with the delusional misidentification syndrome: A case report and literature review.","authors":"Kosuke Matsuzono, Yoshiyuki Onuki, Kyoko Otsuka, Honoka Hiki, Yuhei Anan, Takafumi Mashiko, Reiji Koide, Naoto Kunii, Kensuke Kawai, Shigeru Fujimoto","doi":"10.1177/00368504251322083","DOIUrl":"10.1177/00368504251322083","url":null,"abstract":"<p><p>Delusional misidentification, a rare syndrome in which a patient displays persistent delusional misidentification of individuals or objects, occurs in several types of dementia. However, the pathology of delusional misidentification is still unclear, and there was no data pertaining to striate-frontal projection. Here, we report a case of delusional misidentification following frontotemporal dementia in which complex striate-frontal and some specific frontal gyrus dysfunction were observed. In our presented case, delusional misidentification progressed following frontal atrophy. Believing that her actual daughter had been replaced by her niece, her symptoms of delusional misidentification and frontal atrophy progressed in the short term, and social arrangement was necessary three months after the onset. There were no abnormal neurological findings including parkinsonism and general cognitive function test scores were preserved. Validated by dopamine transporter single-photon emission computed tomography, right unilateral striatal uptake decreased significantly without parkinsonism or Parkinson's disease. In addition, of specific concern, functional magnetic resonance images showed left opercular inferior frontal gyrus and right superior frontal gyrus dysfunctions. Our case study highlights complex striate-frontal projection and specific frontal gyrus dysfunctions associated with the pathology of delusional misidentification syndrome.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251322083"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes and prognostic factors of major amputation in thromboangiitis obliterans after drug therapy and endovascular procedures: A real-world cohort study.","authors":"Hailiang Xie, Jiying Lu, Guofu Zheng, Xiaochun Liu, Weiqing Chen","doi":"10.1177/00368504251320766","DOIUrl":"10.1177/00368504251320766","url":null,"abstract":"<p><strong>Objectives: </strong>Data regarding the long-term outcomes of patients with thromboangiitis obliterans (TAO) after drug therapy (DT) alone and endovascular procedure (EP)+ drug therapy (DT) are limited. In this study, we compared the long-term outcomes and prognostic factors of major amputation in TAO patients treated with DT alone and those treated with EP+ DT.</p><p><strong>Methods: </strong>Consecutive patients with TAO treated at Ganzhou People's Hospital between 2012 and 2022 were included in this real-world study. All patients were administered DT. Some patients were treated with EP in addition to DT. The patients were classified into two groups: the DT group and the EP+ DT group. Long-term follow-up was sustained for all patients after treatment, and limb events were documented throughout the follow-up period. Cox regression analyses were used to analyze the factors associated with major amputation of the TAO.</p><p><strong>Results: </strong>A total of 150 TAO patients with 175 lower limb lesions were included in the study and the number of patients in DT group and EP+ DT group was 81 and 69, respectively. The technical success rate in the EP group was 82.6%. The major amputation was performed in 19 and 21 patients in the respective groups, accounting for 26.7% of the total patients. The Kaplan-Meier curves for major amputation did not significantly differ between the two groups. Cox regression analysis revealed that disease duration (hazard ratio (HR), 0.865; 95% confidence interval (CI) [0.783-0.979], <i>p</i> = 0.005), wound grade (HR, 2.240; 95% CI 1.565-3.207], <i>p</i> < 0.001) and current smoking (HR, 3.075; 95% CI 1.317-7.812], <i>p</i> = 0.009) were independent factors for major amputation in patients with TAO.</p><p><strong>Conclusion: </strong>In terms of long-term outcomes, major amputation in TAO patients did not seem to be related to the treatment methods despite a higher immediate patency rate observed after endovascular procedures. Additionally, we identified independent factors for major amputation.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251320766"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone conduction implants and active middle ear implants for adults.","authors":"Eleonor Koro, Jeremy Wales, Mimmi Werner","doi":"10.1177/00368504251328010","DOIUrl":"10.1177/00368504251328010","url":null,"abstract":"<p><p>Hearing loss is the third most significant cause of disability globally and is associated with anxiety, depression, loneliness, and cognitive decline. For those unable to utilize conventional hearing aids due to conditions such as ear canal atresia, eczema, recurrent external otitis or extensive ear surgery, implantable hearing aids provide an alternative. This narrative review provides an overview of available bone conduction devices and active middle ear implants. The rapid advancements in implantable hearing aid technology necessitate ongoing education of healthcare professionals to enable informed patient decisions.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251328010"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helicobacter pylori and hypertension-a cross-sectional study based on a healthy population.","authors":"Ping Yang, Wei Shi, Hai Liu, Chi Wang, Xianbin Wang, Zengshuai Wang, Guanrong Huang, Guanhua Huang","doi":"10.1177/00368504251320300","DOIUrl":"10.1177/00368504251320300","url":null,"abstract":"<p><strong>Objective: </strong>In this study, we aimed to elucidate the potential association between <i>H. pylori</i> infection and the prevalence of hypertension in the Inner Mongolia population, while also exploring the impact of sex and age on the relationship between helicobacter pylori and hypertension.</p><p><strong>Method: </strong>We collected physical examination data from a cohort of 10,517 patients at the Second Affiliated Hospital of Baotou Medical College between January and December 2020. The patients were categorized into three groups based on their blood pressure and <i>H. pylori</i> infection status. Our findings revealed a significant correlation between <i>H. pylori</i> infection and blood pressure levels in the patients.</p><p><strong>Result: </strong>The infection rate of <i>H. pylori</i> was higher in patients with hypertension compared to those without hypertension. Additionally, sex and age exerted an influence on the association between helicobacter pylori and hypertension. Among the hypertensive patients, males displayed a greater likelihood of <i>H. pylori</i> infection and more severe infections than females. Furthermore, within the hypertensive patients infected with <i>H. pylori</i>, the degree of infection was lower in young adults compared to middle-aged adults and the elderly.</p><p><strong>Conclusion: </strong>Hypertension is associated with Helicobacter pylori infection.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251320300"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental and numerical study on valve dynamic impact contact characteristics and fault diagnosis of a reciprocating piston pump.","authors":"Ran Li, WenShu Wei, YueHua Lai, HaiCheng Lu, TianZe Cao, Jian Ye, Hao Liu","doi":"10.1177/00368504251325327","DOIUrl":"10.1177/00368504251325327","url":null,"abstract":"<p><p>With the increase in power and flow of emulsion pumps, pump valves are more likely to be damaged during long working hours, Therefore, it is important to ensure the reliability of pump valves at all stages. However, there are still some problems that need to be solved urgently. For example, whether the actual dynamic characteristics of the valve are consistent with the simulation results, and whether the simulation can replace experiments to provide a reference for the design improvement of the valve. At the same time, what is the failure mechanism of the valve, and what methods can be used to find the early failure of the valve. Therefore, the dynamic impact contact characteristics and fault diagnosis of valves of reciprocating piston pumps were investigated both experimentally and numerically. They were analyzed using AMESim simulation and U-Adolph theory, respectively, to predict the dynamic characteristics of the valve. The effect of spring stiffness on the dynamic characteristics of the valve was also investigated. The numerical analysis and analytical results are in good agreement with the experimental results, which provide an important reference for the development of new horizontal five-cylinder single-acting reciprocating pumps. In addition, finite element analysis was used to study the impact contact characteristics of the discharge valve closing under different valve diameters. The failure mechanism of the pump and valve was revealed, a fault diagnosis method was proposed, and the effectiveness of the method is verified by experiment.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251325327"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}