Science Progress最新文献

{"title":"Advancements of metallic nanoparticles: A promising frontier in cancer treatment.","authors":"Ali Al-Samydai, Maha N Abu Hajleh, Farah Al-Sahlawi, Hamdi Nsairat, Arwa Al Khatib, Moath Alqaraleh, Alia K Ibrahim","doi":"10.1177/00368504241274967","DOIUrl":"10.1177/00368504241274967","url":null,"abstract":"<p><p>The incidence of cancer is increasing and evolving as a major source of mortality. Nanotechnology has garnered considerable scientific interest in recent decades and can offer a promising solution to the challenges encountered with traditional chemotherapy. Nanoparticle utilization holds promise in combating cancer and other diseases, offering exciting prospects for drug delivery systems and medicinal applications. Metallic nanoparticles exhibit remarkable physical and chemical properties, such as their minute size, chemical composition, structure, and extensive surface area, rendering them versatile and cost-effective. Research has demonstrated their significant and beneficial impact on cancer treatment, characterized by enhanced targeting abilities, gene activity suppression, and improved drug delivery efficiency. By incorporating targeting ligands, functionalized metal nanoparticles ensure precise energy deposition within tumors, thereby augmenting treatment accuracy. Moreover, beyond their therapeutic efficacy, metal nanoparticles serve as valuable tools for cancer cell visualization, contributing to diagnostic techniques. Utilizing metal nanoparticles in therapeutic systems allows for simultaneous cancer diagnosis and treatment, while also facilitating controlled drug release, thus revolutionizing cancer care. This narrative review investigates the advancements of metal nanoparticles in cancer treatment, types and mechanisms in targeting cancer cells, application in clinical scenarios, and potential toxicity in medicine.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241274967"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11459474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial function is preserved in successfully treated patients with psoriasis vulgaris.","authors":"Eva Klara Merzel Šabović, Tadeja Kraner Šumenjak, Mojca Božič Mijovski, Miodrag Janić","doi":"10.1177/00368504241287893","DOIUrl":"10.1177/00368504241287893","url":null,"abstract":"<p><strong>Introduction: </strong>Endothelial dysfunction is an early precursor of atherosclerosis and is common in patients with psoriasis, presumably primarily due to psoriasis-related inflammation. We investigated endothelial function, arterial stiffness, and circulating markers of endothelial activation in young patients with psoriasis vulgaris of varying severity, all of whom were effectively treated achieving PASI 90.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of 80 patients (54 men/26 women, 30-45 years) who were effectively treated with topical therapy, methotrexate, adalimumab, secukinumab or guselkumab, and 20 healthy controls. Endothelial dysfunction was measured by flow-mediated dilation and arterial stiffness was measured by pulse wave velocity and common carotid artery stiffness. The following circulating biomarkers of endothelial activation were measured: ICAM-1, VCAM-1, E- and P-selectin, GDF-15, and TRAIL.</p><p><strong>Results: </strong>Endothelial function and arterial stiffness parameters did not differ between patients with effectively treated psoriasis and the control group. Circulating endothelial activation biomarkers did not show relevant differences between the groups of effectively treated patients or controls.</p><p><strong>Discussion: </strong>Although cardiovascular disease is the leading cause of morbidity and mortality in patients with psoriasis, effective antipsoriatic treatment appears to slow the progression of atherosclerosis, even when there are cardiovascular risk factors, such as smoking or obesity. This may suggest that antipsoriatic treatment exerts a cardioprotective effect.</p><p><strong>Conclusions: </strong>Our results suggest that early and effective treatment of varying-severity psoriasis vulgaris in young patients appears to prevent arterial dysfunction related to psoriasis and consequent cardiovascular risk.The study is registered at http://clinicaltrials.gov (identifier: NCT05957120).</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241287893"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of hand-made versus commercial stent grafts in frozen elephant trunk.","authors":"Shinji Kanemitsu, Renta Ishikawa, Shunsuke Sakamoto, Toru Mizumoto","doi":"10.1177/00368504241278415","DOIUrl":"10.1177/00368504241278415","url":null,"abstract":"<p><strong>Objectives: </strong>The frozen elephant trunk (FET) technique is effective for treating extended aortic arch aneurysms. This study compares hand-made and factory-made devices in this context.</p><p><strong>Methods: </strong>A retrospective case-control study was conducted on 68 patients who underwent FET for distal aortic arch aneurysm at our institution. We used two different types of devices: hand-made stent graft in group Z (17 cases, 25.0%) and a commercialized stent graft in group J (51 cases, 75.0%). The study compared demographic characteristics and the outcomes between the two groups.</p><p><strong>Results: </strong>In-hospital mortality was equivalent in both groups (5.9%). Spinal cord injury rates were 5.9% in group Z and 3.9% in group J. Group Z had a higher rate of aortic events (55.9% vs 96.9%, <i>p</i> < 0.001) and more frequent stent migration. The number of cases with aneurysm diameter shrinkage was lower in group Z. The landing zone angle at insertion influenced aneurysm changes, being 17.6 degrees in shrink cases and 26.7 degrees in unchanged or enlarged cases (<i>p</i> = 0.045).</p><p><strong>Conclusions: </strong>FROZENIX device notably reduced incidences of postoperative complications compared to hand-made prostheses. Factors such as insertion angle and stent size, rather than changes in the landing zone angle, appeared to influence aneurysm shrinkage. The use of FROZENIX in TARFET procedures has shown benefits in reducing complications and improving long-term prognosis, taking into account the landing zone angle.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241278415"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Submucosal tunneling endoscopic resection for a rectal schwannoma: A rare case.","authors":"Chunxiao Hu, Xiaohua Ye","doi":"10.1177/00368504241297202","DOIUrl":"10.1177/00368504241297202","url":null,"abstract":"<p><p>Rectal Schwannomas are exceptionally uncommon tumors that arise from the peripheral nerve plexus. These neoplasms are incidentally discovered as submucosal tumor-like lesions during routine colonoscopy in individuals without symptoms. Surgical resection accompanied by biopsy is considered the standard approach for diagnosis and treatment. We describe here the first successful utilization of submucosal tunneling endoscopic resection (STER) technique for removal of a rare rectal Schwannoma. A 59-year-old asymptomatic female was found to have a 15 × 12 mm submucosal tumor during colonoscopy. Submucosal tunneling endoscopic resection achieved <i>en bloc</i> resection and pathology confirmed Schwannoma. The patient was discharged uneventfully with no adverse events. This study highlights the efficacy and safety of STER for removing rare rectal Schwannomas.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241297202"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A secure transaction and smart contract architecture for internet of vehicles.","authors":"Hua-Yi Lin","doi":"10.1177/00368504241296039","DOIUrl":"10.1177/00368504241296039","url":null,"abstract":"<p><p>Recently, with the popularity of Internet of vehicles (IoV), there is an increasing market demand for integrating blockchain technology and smart contracts in electric vehicles. By utilizing distributed blockchain and smart contract technology, it provides data integrity preservation, traceability, and prevention of forgery. These features can be effectively used in the automated charging system. As a result, IoV can utilize blockchain and smart contract technologies to facilitate seamless payment for charging fees, tolls, parking fees, online shopping and other associated expenses without the need for intermediaries. However, since blockchain and smart contracts operate in an open internet environment, there is a risk of tampering with transaction records. Therefore, enhancing security becomes a crucial concern. The main aim of this study is to emphasize the growing significance of securing transactions and smart contracts in an open transmission environment to prevent potential damage or alteration.In order to achieve the implementation of secure smart contracts within a resource-constrained IoV, this study investigates various cryptographic mechanisms and realizes the elliptic curve cryptosystem (ECC) is widely recognized for providing strong security with shorter key lengths compared to other public key cryptography methods. This makes it ideal for environments with limited resources. Furthermore, in order to enhance the performance of smart contracts, this study proposes a cloud server architecture for parallel storage of smart contracts to improve access speed. Additionally, we introduce an automated trading framework for smart contracts that operates without human intervention.Finally, this study uses ECC to ensure the secure transmission of transaction data among the vehicle, base station, and cloud server, as well as to provide mutual verification of identities across all entities involved in the operation. As a result, this study proposes a secure architecture for blockchain and smart contracts that can autonomously initiate transactions while ensuring secure transmission and protection in the IoV.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241296039"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the quality and consumer satisfaction of dragon fruit beverage production: The effects of geological origin and processing conditions.","authors":"Thinh Van Pham, Thuy Xuan Cao, Ngoc Thi Hong Le, Ai Minh Pham, Hung Tuan Trinh, Dat Tien Nguyen, Anh Le Tuan Hoang, Minh Quang Bui, Tung Ngoc Nguyen, Minh Ngoc Truong, Tao Minh Hoang","doi":"10.1177/00368504241300854","DOIUrl":"10.1177/00368504241300854","url":null,"abstract":"<p><strong>Objectives: </strong>In this study, the impacts of various processing parameters on the quality and consumer satisfaction of dragon fruit beverages were investigated in order to establish an informative framework for the manufacturing of commercial dragon fruit beverages, focusing on health benefits and safety for consumers, and sensory appeal of the products.</p><p><strong>Methods: </strong>This study employed various analytical methods to quantify some important phytochemical compounds in dragon fruit juice such as total and reducing sugars, vitamin C, betacyanins, anthocyanins, polyphenol, and so forth. This study also employed the Box-Behnken response surface experimental design to optimize various processing parameters for quality and consumer satisfaction, which include enzymatic pectin hydrolysis parameters and formulation for dragon fruit energy drink.</p><p><strong>Results: </strong>The results from this study indicated a causal relationship between geological origin and some important characteristics of dragon fruit juice, emphasizing the need to track the source of fruits to ensure consistent quality of juice products. This study also systematically determined the impacts of various enzymatic hydrolysis, thermal sterilization, and formulation parameters on both nutrition content and sensory aspects of dragon fruit beverages, while also successfully optimized these parameters for the best outcomes.</p><p><strong>Conclusion: </strong>This study had successfully achieved the objective of establishing a valuable framework for the manufacturing of commercial dragon fruit beverages, focusing on health benefits and safety for consumers, and sensory appeal of the products.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241300854"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11622313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and implementation of a field robot using a parallelogram mechanism.","authors":"Thanh Phuong Nguyen, Hung Nguyen, Thinh Ngo","doi":"10.1177/00368504241291124","DOIUrl":"10.1177/00368504241291124","url":null,"abstract":"<p><p>To meet various industrial requirements such as ease of motion, scalability, and cost efficiency, it is necessary to innovate the design of robotic platforms. In this research, a novel approach, from mechanical design to control implementation, is introduced for launching a robotic platform using a parallelogram mechanism. First, a reverse engineering process is applied, progressing from kinematics to dynamics. Then, several mechanical computations are conducted to ensure the structural stability of the robot framework. Subsequently, the dynamic performance of the system is analyzed, focusing on the driving torque and moments in each link. Additionally, the electrical design and transfer function of each joint are identified to ensure practical execution. To validate the effectiveness and feasibility of the design, both numerical simulations and experimental tests are performed. Theoretical results show the dynamic response of the proposed method, particularly in terms of the driving moments of the robotic joints. In real-world tests, various trajectories, such as different rectangular paths, are demonstrated to showcase the robot's capabilities. From these results, it is clear that the proposed approach is both feasible and applicable in practical scenarios.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241291124"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142513547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of walking performance between individuals with and without asymptomatic peripheral artery disease using the six-minute walk test and the incremental shuttle walk test.","authors":"Sothida Nantakool, Busaba Chuatrakoon, Cattaleeya Sittichoke, Supatcha Konghakote, Kittipan Rerkasem, Supawan Buranapin, Sawat Kanlayanee, Natthaset Pothaya, Jitbergbarn Kidarn","doi":"10.1177/00368504241305822","DOIUrl":"10.1177/00368504241305822","url":null,"abstract":"<p><strong>Objective: </strong>Two walking tests including the six-minute walk test (6MWT) and the incremental shuttle walk test (ISWT) are widely used to evaluate functional ability in individuals with disease conditions. However, it remains unclear whether these walking tests effectively manifest clinical impairment in individuals with asymptomatic peripheral artery disease (PAD). We aimed (i) to compare the walking performance of individuals with and without asymptomatic PAD using the 6MWT and ISWT, and (ii) to investigate the correlation between ankle-brachial index and toe-brachial index (ABI-TBI) and the walking distance.</p><p><strong>Methods: </strong>A cross-sectional, crossover, matched pairs design was employed in this study. Asymptomatic PAD was diagnosed using ABI-TBI measurements. Seventy-six participants (38 with asymptomatic PAD and 38 without PAD) were randomly ordered to perform the walking tests. During the 6MWT, participants walked along the 30-meter corridor at their self-selected pace for six minutes, and the six-minute walk distance (6MWD) covered was recorded. In the ISWT, participants walked at a 12 prescribed speed level, and the incremental shuttle walk distance (ISWD) covered was recorded.</p><p><strong>Results: </strong>Result revealed no difference in 6MWD between individuals with asymptomatic PAD and without PAD (mean distance: 501.6 m vs 516.8 m, p = 0.24). Asymptomatic PAD individuals exhibited a significantly shorter ISWD than those without PAD (median distance: 270 m vs 340 m, p = 0.003). No participants reported any leg pain symptoms during the 6MWT and ISWT. A statistically significant positive correlation was observed between the right leg TBI and ISWD in all participants (r = 0.23, p = 0.04).</p><p><strong>Conclusions: </strong>Individuals with asymptomatic PAD demonstrated poorer walking performance than those without PAD when assessed using ISWT but not the 6MWT. Asymptomatic PAD is also associated with diminished walking performance during the ISWT. Thus, ISWT may show the clinical impairment in this population.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241305822"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical and diffusion property and multi-objective optimization of rubber seals exposed to high-pressure hydrogen gas.","authors":"Yi Ma, Xuhang Wu, Xiaoling Deng, Xudong Peng, Xiangkai Meng","doi":"10.1177/00368504241304197","DOIUrl":"10.1177/00368504241304197","url":null,"abstract":"<p><p>As the critical components in hydrogen refueling, storage, and transportation systems, the degradation and failure of rubber O-ring seals under a high-pressure (HP) hydrogen environment (up to 100 MPa) directly affect hydrogen energy safety. Clarifying the interaction mechanism of hydrogen diffusion and the mechanical properties of rubber seals is essential for HP hydrogen infrastructure. A hydrogen diffusion-mechanical sequential numerical model is built to investigate the sealing performance and hydrogen diffusion behaviors of rubber seals using ABAQUS software. The effects of hydrogen swelling environmental pressure (5∼100 MPa) and stress-concentration gradient on mechanical and contact characteristics and hydrogen concentration distribution are analyzed for the rubber seals with/without backup rings, respectively. Furthermore, the orthogonal experimental and comprehensive frequency analysis methods are employed to evaluate the significance of the main structural and assembly parameters and obtain the optimal schemes of the rubber seals under the HP environment. The results show that the stress concentration and rubber extrusion easily occur at the sealing clearance of the O-rings with swelling after pre-compression and pressurization. The hydrogen diffusion of the O-ring is mainly driven by the concentration difference and stress gradient, with the former being the dominant factor. With the increase in the hydrogen pressure, the effective sealing rate along the sealing surface decreases sharply, and the non-uniformity of hydrogen concentration and the possibility of fatigue damage in the rubber O-rings increase. Two multi-objective optimization schemes (Ⅰ and Ⅱ) for the main structural and assembly parameters of rubber seals are obtained by intuitive analysis and comprehensive frequency analysis to improve the extrusion tendency and sealing reliability of rubber seals in the HP hydrogen environment.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241304197"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on surface roughness of high-speed milling 7075-T6 aluminum alloy using nanofluid/ultrasonic atomization minimal quantity lubrication system.","authors":"Wen-Hsien Ho, Jinn-Tsong Tsai, Wei-Tai Huang","doi":"10.1177/00368504241284823","DOIUrl":"10.1177/00368504241284823","url":null,"abstract":"<p><p>This study employed a self-developed nanofluid/ultrasonic atomization minimal quantity lubrication system. The use of ultrasonic cavitation can effectively improve the accumulation of nanofluids via van der Waals force bonding and enhance their efficiency. This system is a high-speed milling manufacturing innovation in lubrication technology. Two types of nanoparticles (multiwalled carbon nanotubes and MoS₂ nanoparticles) were used to facilitate the mixing of nanofluids and their lubrication in the high-speed milling of 7075-T6 aluminum alloy. The surface roughness of each group of experimental results was used as the characteristic index. The surface roughness obtained from the optimization of the experimental results was 0.51 μm, while the worst group, which was based on the original orthogonal table, had a surface roughness of 1.05 μm, demonstrating an improvement of 51.43% in the quality characteristics. Results of comparative experiments demonstrated that using a nanofluid mixed with multiwalled carbon nanotubes and MoS₂ nanoparticles exerted better effects on surface roughness, tool wear, and workpiece burrs than using only nanofluids with single nanoparticles. This finding can be attributed to the mixed nanofluid, which simultaneously possesses the good grinding capability of MoS₂ and the excellent heat transfer property of multiwalled carbon nanotubes.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"107 4","pages":"368504241284823"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}