Science Progress最新文献

{"title":"Retraction.","authors":"","doi":"10.1177/00368504251364957","DOIUrl":"https://doi.org/10.1177/00368504251364957","url":null,"abstract":"","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251364957"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing microwave-sensitive coatings for enhanced de-icing efficiency: Effects of frequency, antenna design, and surface geometry.","authors":"Huaiguang Xiao, Weiqiang Zhu, Yifan Wang, Lei He","doi":"10.1177/00368504251366370","DOIUrl":"https://doi.org/10.1177/00368504251366370","url":null,"abstract":"<p><p>Microwave de-icing technology demonstrates significant application potential for anti-icing and de-icing various infrastructures due to its environmentally friendly, non-contact, and straightforward operation. However, further research and optimization are required under different microwave conditions, antenna types, and complex engineering surface structures. This paper employs numerical simulation methods to investigate the temperature rise behavior of coating surfaces under varying microwave power and irradiation times, validated through physical experiments. The results indicate that at an irradiation distance of 5 cm, the critical microwave incidence angle is approximately 20°, with minimal impact on the heating effect of the coating. Increasing the microwave frequency accelerates the heating rate but reduces uniformity, with 5.8 GHz causing uneven heating and 0.915 GHz providing more uniform heating. A frequency of 2.45 GHz is recommended to achieve a balance between heating rate and uniformity. Additionally, as the irradiation distance increases, heating efficiency decreases. Horn antennas demonstrate advantages over standard rectangular waveguide antennas by reducing energy loss over long distances, covering a larger area, and improving heating uniformity. Curved surface coatings demonstrate superior heating characteristics, offering valuable insights for de-icing structures with complex shapes.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251366370"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term progression-free survival in a patient with extensive-stage small-cell lung cancer following second-line therapy with anlotinib and palliative chemoradiotherapy: A case report.","authors":"Ning Zan, Danfei Yu, Xuan Zhang, Zhiyu Lin","doi":"10.1177/00368504251382043","DOIUrl":"10.1177/00368504251382043","url":null,"abstract":"<p><p>Lung cancer is among the most common types of malignancies, with small-cell lung cancer (SCLC) being a particularly aggressive subtype. The prognosis for SCLC is typically poor once it recurs and metastasizes after first-line treatment. Although numerous studies have investigated second-line therapies for SCLC, the outcomes have been suboptimal. In this case report, we examined the effectiveness of anlotinib combined with palliative chemoradiotherapy in a patient with second-line treatment of SCLC. The patient achieved a long progression-free survival of 31 months with anlotinib combined with palliative chemoradiotherapy. Anlotinib combined with palliative chemoradiotherapy may offer significant therapeutic benefits as a second-line recurrent or metastatic SCLC.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251382043"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary adrenal CD56-negative extranodal NK/T-cell lymphoma: Case report and literature review.","authors":"Ying Chen, Daping Zhong, Xin He, Lina Wang, Yujuan Xu, Deyu Guo","doi":"10.1177/00368504251368731","DOIUrl":"10.1177/00368504251368731","url":null,"abstract":"<p><p>Primary adrenal extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is exceptionally rare, and it remains unclear whether this subtype of ENKTL exhibits distinct clinicopathological features. This case report describes a later 30s female patient who presented with 6 months of back pain. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) revealed a hypermetabolic left adrenal mass. Histopathology revealed diffuse atypical lymphocytes with necrosis and vascular invasion. Immunohistochemical analysis demonstrated tumor cell positivity for CD3, CD2, CD8, TIA-1, and granzyme B, while being negative for CD5, CD4, CD56, CD20, Pax-5, CD30 and keratin, with a Ki-67 proliferation index of approximately 80%. Chromogenic in situ hybridization showed strong and uniform nuclear positivity of Epstein-Barr virus-encoded RNA (EBER) in the neoplastic population. T-cell receptor rearrangement (TR-γ) was in germline configuration. The final diagnosis of primary adrenal CD56-negative extranodal NK/T-cell lymphoma was confirmed. Chemotherapy was initiated immediately. But she died within 4 months because of disease progression. Primary adrenal ENKTL appears to be exceedingly rare and might portend a particularly poor prognosis. CD56 negativity and advanced stage could potentially represent key prognostic determinants.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251368731"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144876966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortocoronary flap technique in arterial switch for single coronary: Two case reports.","authors":"Dhama Shinta Susanti, Chaisari Maria Turnip, Matthew Billy","doi":"10.1177/00368504251361802","DOIUrl":"10.1177/00368504251361802","url":null,"abstract":"<p><p>Single coronary ostium and intramural coronary artery variations in patients with transposition of the great arteries significantly increase the mortality and morbidity after arterial switch operation (ASO). In these patients, the classic coronary button implantation may cause kinking or twisting of the coronary artery which can cause coronary insufficiency. This case series presents two patients, a 15-month-old girl with transposition of the great arteries and a 10-month-old boy with a Taussig-Bing anomaly. Both underwent ASO using the aortocoronary flap technique for coronary button transfer. The coronary augmentation with the right subclavian artery technique compromises the circulation to the arm. Meanwhile, the graft reconstruction needs a tunnel/tube, thus causing risk for thrombosis. Hence, aortocoronary flap technique was preferred in this case report. Postoperative evaluations showed no ST-segment changes and no regional wall motion abnormalities. Intensive care unit (ICU) stay after ASO was 21 days and 14 days, and postoperative length of stay was 26 days and 17 days, respectively. Aortocoronary flap technique is a promising method for coronary button implantation in patient with single ostium and intramural coronary artery to prevent coronary insufficiency due to twisting and kinking of the coronary artery.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251361802"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic findings as a prognostic factor in parotid cancer.","authors":"Jeong Heon Kim, Jeong Ho Woo, Minsu Kwon, Young Ho Jung, Seung-Ho Choi, Yoon Se Lee","doi":"10.1177/00368504251356179","DOIUrl":"10.1177/00368504251356179","url":null,"abstract":"<p><p>ObjectiveRecent advancements in high-resolution ultrasonography (US) have established it as a critical tool for evaluating parotid lesions. However, the lack of standardized diagnostic criteria limits the utility of US in determining malignancy. This study investigates the potential role of US as a prognostic factor in parotid cancer.MethodsPatients diagnosed with and surgically treated for parotid cancer at our tertiary referral center from January 2016 to December 2022 were included in this retrospective cohort study. We retrospectively obtained patient data including US images and clinical factors and analyzed their correlation with various adverse features and oncological outcomes, including five-year disease-free survival (5Y DFS) and overall survival (5Y OS).ResultsA total of 126 patients were included. The 5Y DFS and 5Y OS were 81.7% ± 3.7% and 81.2% ± 4.1% respectively. Multivariate analysis revealed that age (DFS; HR 2.75 [1.76-4.29], <i>p</i> = .023, OS; HR 3.38 [2.06-5.54], <i>p</i> = .014), clinical nodal stage (DFS; HR 5.87 [3.74-9.21], <i>p</i> < .001, OS; HR 9.34 [5.48-15.91], <i>p</i> < .001) and the presence of posterior enhancement artifact on US (DFS; HR 0.33 [0.21-0.53], <i>p</i> = .019, OS; HR 0.34 [0.20-0.57], <i>p</i> = .037) were significant variables. In patients with early-stage parotid cancer who showed posterior enhancement, the extent of surgery did not affect treatment outcomes.ConclusionPosterior acoustic enhancement on ultrasonography is a favorable prognostic factor in parotid cancer. For patients with early-stage cancer who demonstrate posterior enhancement, minimizing the extent of surgery does not compromise oncologic outcomes.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251356179"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise's protective role in chronic obstructive pulmonary disease via modulation of M1 macrophage phenotype through the miR-124-3p/ERN1 axis.","authors":"Haizhu Zeng, Xiaoxiang Liu, Panpan Liu, Shuyin Jia, Guangyu Wei, Guo Chen, Lei Zhao","doi":"10.1177/00368504251360892","DOIUrl":"10.1177/00368504251360892","url":null,"abstract":"<p><p>ObjectiveChronic obstructive pulmonary disease is a leading cause of global mortality. Although exercise training improves lung function and quality of life in chronic obstructive pulmonary disease patients, its mechanisms remain unclear. This study aims to reveal the effects of exercise on chronic obstructive pulmonary disease and elucidate the underlying molecular mechanisms involved.MethodsThis pre-post observational cohort study included 11 chronic obstructive pulmonary disease patients who underwent a 12-week exercise training program to evaluate the effects of exercise intervention. A cigarette smoke-induced chronic obstructive pulmonary disease mouse model and a cigarette smoke extract-induced bronchial endothelial cell model were utilized to investigate the protective mechanisms of exercise. Next-generation sequencing, bioinformatics analyses, luciferase reporter assays, and RT-qPCR were employed to assess mRNA and miRNA expression levels and correlation. Bioinformatics analysis and luciferase reporter assays were performed to identify direct downstream targets of miR-124-3p.ResultsExercise ameliorated lung inflammation in chronic obstructive pulmonary disease mouse lung tissue and human peripheral blood leucocytes. It inhibited M1 macrophage activation in response to cigarette smoke extract and led to the upregulation of miR-124-3p expression. Overexpression of miR-124-3p attenuated cigarette smoke extract-induced lung injury and inflammatory responses. Luciferase reporter assays identified endoplasmic reticulum to nucleus signaling 1 as a direct downstream target of miR-124-3p, and endoplasmic reticulum to nucleus signaling 1 overexpression reversed the anti-inflammatory effects mediated by miR-124-3p.ConclusionsExercise improved patient endurance and alleviated emphysema-related inflammation. It increased miR-124-3p expression, which inhibited the M1 macrophage phenotype and attenuated smoking-related lung injury by targeting endoplasmic reticulum to nucleus signaling 1.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251360892"},"PeriodicalIF":2.6,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ion-channel mRNA expression alterations in a cervical dorsal horn compression induced novel rabbit model of trigeminal neuropathic pain.","authors":"Zülfükar Kadir Sarıtaş, Ülkü Türk Börü, Metin Erdoğan, Cem Bölük, Fatma Görücü Özbek, Hakan Acar, Yusuf Koç, Furkan İncebacak","doi":"10.1177/00368504251376909","DOIUrl":"10.1177/00368504251376909","url":null,"abstract":"<p><p><b>Objective:</b> A considerable number of individuals are diagnosed with idiopathic trigeminal neuralgia. In order to achieve a more complete understanding of the pathophysiology, it is essential to adopt a range of novel approaches and utilize new animal models. This study investigated changes in the messenger RNA (mRNA) expression of ion-channels in a newly developed animal model of trigeminal neuropathic pain induced by cervical spinal dorsal horn compression. <b>Methods:</b> Eighteen rabbits were randomly assigned into three groups (spinal cord compression, sham, and control groups), and a previously developed animal model was applied. Quantitative polymerase chain reaction was applied to examine the genetic expression of Na, K, and Ca channels in the cervical dorsal horn, trigeminal ganglion, and infraorbital nerve. <b>Results:</b> The mRNA expression levels of SCN8A and SCN9A exhibited a marked increase in the infraorbital nerve of the spinal cord compression group when compared to the sham group. Furthermore, the mRNA expression levels of CACNA1C, KCNK1, and SCN9A demonstrated a significant increase in all investigated regions when compared to the control group. <b>Conclusions:</b> The present findings indicate the potential critical involvement of Nav1.6 and Nav1.7 in the pathogenesis of trigeminal neuropathic pain. However, the potential involvement of the CaV2.1, CaV1.2, and K2P1.1 channels cannot be ruled out at this juncture.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251376909"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical research of slosh characteristics by baffles in the liquid helium portable tank.","authors":"Jia Qiming, Guo Liang, Xie Xiujuan, Liu Liqiang","doi":"10.1177/00368504251374383","DOIUrl":"10.1177/00368504251374383","url":null,"abstract":"<p><p>This article addresses the challenges posed by the unique vapor-liquid physical properties of helium, specifically, focusing on the slosh of liquid helium caused by shaking during transportation. A three-dimensional model of a baffle structure is developed to prevent sloshing in the liquid helium portable tanks. Literature-based verification of simulation model via gas-liquid interface data shows <8.5% error, proving its effectiveness. The slosh characteristics are numerically compared, considering parameters such as phase interface area, internal temperature uniformity, and pressure variation at head. The results demonstrate that an optimal oscillation excitation amplitude of 5.57 m/s² is identified. Investigating vapor-liquid phase, pressure, and velocity variations with/without baffles in liquid helium tanks. Additionally, the variation in liquid phase fraction with baffle is analyzed to assess their effectiveness in mitigating internal pressure impact during the storage and transportation. These insights hold significant implications for ensuring safe and efficient transportation of liquid helium on highways.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251374383"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12409050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144979642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis for osteoarthritis of the ankle joint in a mouse model of chronic ankle instability.","authors":"Ju-Young Kim, So Young Eun, Gyeong Hoon Lim, Min Hyeok Kim, Sung Hyun Lee","doi":"10.1177/00368504251367279","DOIUrl":"10.1177/00368504251367279","url":null,"abstract":"<p><p>ObjectiveThis study aimed to assess osteoarthritic changes in the ankle joint in a surgical model of chronic ankle instability (CAI) in mice.MethodsThis experimental study was conducted this study using 14-week-old Institute of Cancer Research (ICR) male mice (<i>n</i> = 19), divided into the sham control ([SH], <i>n</i> = 5), anterior talofibular ligament resection ([ATFL]; mild sprain, <i>n</i> = 7), and ATFL + calcaneofibular ligament resection ([ATFL + CFL]; severe ankle injury, <i>n</i> = 7) groups. A combination of behavioral analysis, micro-computed tomography, immunohistochemical staining, and serological analysis through enzyme-linked immunosorbent assay was performed to evaluate the outcomes.ResultsA decrease in hind-leg standing was observed in the injured mouse groups, indicating signs of discomfort. Significant deterioration in cartilage integrity and joint structure was quantitatively confirmed in the ATFL + CFL group. Increased cartilage erosion and subchondral bone damage were observed. Serological analysis revealed elevated levels of inflammatory cytokines (TNF-α, IL-6, and IL-1β) in the ATFL + CFL group, suggesting a heightened inflammatory response.ConclusionsThis study demonstrated that severe CAI, particularly that involving both the ATFL and CFL, directly contributes to the development of ankle osteoarthritis. This highlights the critical need for targeted interventions in preventing or mitigating this progression.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 3","pages":"368504251367279"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}