Science Progress最新文献

{"title":"Single versus dual antiplatelet therapy impact on coagulation/thrombosis post PAD revascularization.","authors":"Adriana A Rodriguez Alvarez, Shiv S Patel, Isabella F Cieri, Samir Ghandour, Mounika Boya, Sasha P Suarez, Aniket Agrawal, Ivy Lee, Lois Owolabi, Mohit Manchella, Anahita Dua","doi":"10.1177/00368504251324332","DOIUrl":"10.1177/00368504251324332","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and compare the impact of single- versus dual-antiplatelet (SAPT vs DAPT) therapy on coagulation profiles and postoperative outcomes in patients with peripheral arterial disease (PAD).</p><p><strong>Methods: </strong>Patients with PAD undergoing lower extremity revascularization from December 2020 to August 2023 were prospectively enrolled in this cohort study and followed for one year to record the incidence of thrombotic events (TEs). These events include arterial graft/stent occlusion or stenosis, as identified through Doppler ultrasonography or angiography. Patients were categorized by type of intervention (open vs. endovascular) and further stratified by thromboprophylaxis regimen (SAPT vs DAPT). Descriptive statistics were conducted to characterize each group. Differences in continuous variables were analyzed using Student's t-test, while categorical variables were evaluated using Fisher's exact test. Kaplan-Meier survival curves and cox proportional hazard assessed the thrombosis probability between groups.</p><p><strong>Results: </strong>A total of 157 patients were analyzed, of which 56 were open and 101 were endovascular. In the endovascular group, the majority of patients were on DAPT (61.4%), whereas in the open procedure, most individuals were on SAPT (78.6%). DAPT recipients exhibited a lower prothrombotic profile than SAPT recipients in either operative cohort (<i>p < </i>.05). However, the incidence of index TEs was similar between medication groups within each cohort over the one-year follow-up period. DAPT was associated with a decreased incidence of recurrent TEs in the open intervention group (<i>p < </i>.001), indicating its potential for reducing subsequent thrombotic complications following an index TE. Additionally, there was no significant difference in thrombosis probability between endovascular and open procedures (<i>p = </i>.73), nor between DAPT and SAPT groups across both procedure modalities (<i>p = </i>.98).</p><p><strong>Conclusion: </strong>While DAPT demonstrated lower prothrombotic thromboelastography with platelet mapping profiles compared to SAPT, this did not translate into differences in index TEs across surgical modalities.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251324332"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning methods for improving the accuracy and efficiency of pathological image analysis.","authors":"Tangsen Huang, Xingru Huang, Haibing Yin","doi":"10.1177/00368504241306830","DOIUrl":"10.1177/00368504241306830","url":null,"abstract":"<p><p>This study presents a novel integration of two advanced deep learning models, U-Net and EfficientNetV2, to achieve high-precision segmentation and rapid classification of pathological images. A key innovation is the development of a new heatmap generation algorithm, which leverages meticulous image preprocessing, data enhancement strategies, ensemble learning, attention mechanisms, and deep feature fusion techniques. This algorithm not only produces highly accurate and interpretatively rich heatmaps but also significantly improves the accuracy and efficiency of pathological image analysis. Unlike existing methods, our approach integrates these advanced techniques into a cohesive framework, enhancing its ability to reveal critical features in pathological images. Rigorous experimental validation demonstrated that our algorithm excels in key performance indicators such as accuracy, recall rate, and processing speed, underscoring its potential for broader applications in pathological image analysis and beyond.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241306830"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving building extraction from high-resolution aerial images: Error correction and performance enhancement using deep learning on the Inria dataset.","authors":"Serdar Ekiz, Ugur Acar","doi":"10.1177/00368504251318202","DOIUrl":"10.1177/00368504251318202","url":null,"abstract":"<p><p>Extracting buildings from images is crucial for urban management, urban planning, and post-disaster change detection. Over the years, various approaches have been tried, but the recent application of deep learning has greatly improved the success of such studies. In this study, the Inria dataset was used, consisting of 180 high-resolution aerial images.The study compared the performance of various architectures. DeepLabv3+ emerged as the most successful, with Accuracy, IoU, and F1 Scores of 96.77%, 89.85%, and 94.53%, respectively. Attention U-Net followed, scoring 95.31%, 85.49%, and 91.95%. U-Net, tested with different encoders, achieved average results of 97.22%, 84.78%, and 90.79%. SE-ResNeXt-50 was the best-performing encoder, followed by SE-ResNet-50, ResNeXt-50, and ResNet-50. UNet++ achieved 94.48% Accuracy, 83.09% IoU, and 90.45% F1 Score, while U2Net obtained 94.09%, 82.26%, and 89.88%, making them less successful.When examining the models under challenging conditions, SE-ResNeXt-50 was the most robust, successfully handling scenarios like occlusion by trees and complex indoor gardens. Conversely, Attention U-Net and UNet++ were more prone to errors, particularly when vehicles were parked near buildings or in the presence of shipping containers, where false positives were common. ResNet-50 struggled with concrete gardens, while U2Net showed better results in scenarios involving indoor gardens.These results, compared to other studies using the same dataset with different pixel sizes, show that eliminating erroneous data and resizing images can enhance the performance of deep learning networks. Therefore, by refining the data and adjusting the image sizes, models can make more accurate and efficient building detections.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251318202"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and external validation of Global Leadership Initiative on Malnutrition-dictated nomograms predicting long-term mortality in hospitalized patients with cirrhosis.","authors":"Qing Liu, Yumei He, Fang Yang, Gaoyue Guo, Wanting Yang, Liping Wu, Chao Sun","doi":"10.1177/00368504251320157","DOIUrl":"10.1177/00368504251320157","url":null,"abstract":"<p><strong>Objectives: </strong>Global Leadership Initiative on Malnutrition (GLIM) criteria have gradually accounted for the mainstay evaluating nutritional status. We sought to establish GLIM-dictated nomograms with other prognostic factors influencing long-term mortality and externally validate their predictive performance in decompensated cirrhosis.</p><p><strong>Methods: </strong>The derivation cohort comprised 301 patients presenting with cirrhosis-associated acute insults, while the validation cohort encompassed 101 subjects from another tertiary hospital. Two nomograms were constructed to predict the 1-year all-cause mortality by integrating the GLIM criteria. The study population was stratified into low-, moderate- and high-risk mortality groups according to aforesaid proposed models.</p><p><strong>Results: </strong>Adjusting Child-Turcotte-Pugh classification (Nomo#1) or Model for End-stage Liver Disease-Sodium score (Nomo#2) separately, the GLIM criteria were independently associated with 1-year mortality in the multivariate Cox regression analysis (Nomo#1 hazard ratio (HR) = 3.139, <i>p</i> < 0.001; Nomo#2 HR = 3.456, <i>p</i> < 0.001). The C-index and time AUC for Nomo#1 and Nomo#2 performed significantly better than those of the GLIM criteria or conventional scoring systems alone. The survival rate of the low-risk group was significantly higher than those of the moderate- or high-risk groups (Nomo#1: 95% <i>vs</i> 65.8% <i>vs</i> 33.3%, <i>p</i> < 0.001; Nomo#2: 94.3% <i>vs</i> 64.5% <i>vs</i> 25%, <i>p</i> < 0.001). Furthermore, our proposed models exhibited moderate prediction accuracy and may identify malnourished patients with poor survival conditions in the external validation cohort.</p><p><strong>Conclusion: </strong>GLIM criteria-defined malnutrition negatively impacted long-term mortality in the context of decompensated cirrhosis. Our established nomograms may predict survival status with sufficient discriminatory ability, alongside good consistency and clinical benefits, supporting their effectiveness in daily practice.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251320157"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143450925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk assessment of existing buildings in tunnel construction based on an improved cumulative prospect theory method.","authors":"Lixin Chang, Norhaiza Nordin, Xinhua Gu, Ye Zhao","doi":"10.1177/00368504251320350","DOIUrl":"10.1177/00368504251320350","url":null,"abstract":"<p><p>As urbanization in China continues to rise, an increasing number of cities are constructing subway tunnels. However, due to the complexity and ambiguity of subway tunnel construction, there is a lack of precise methods to assess the impact of these constructions on surrounding buildings. Consequently, this study analyzes and summarizes past experiences and proposes the IVTSFS-CPT-EDAS model based on the CPT-EDAS evaluation method. This model establishes a risk assessment approach specifically for the impact of subway tunnel construction on existing buildings. The model's process was validated through a real-world case study, including a sensitivity analysis to verify its effectiveness and feasibility. The findings of this study indicate: (1) The IVTSFS-CPT-EDAS model can more comprehensively and delicately replicate the actual decision-making environment, enhancing the accuracy of the model. (2) The analysis of expert evaluations indicates that improper material and equipment configuration, inadequate excavation pressure control, and non-compliance of the stratum solubility coefficient with requirements are the primary risk factors affecting the building. (3) The advantages of the proposed model over other approaches and the accuracy enhancement of the assessment results due to the improvements in the evaluation method were demonstrated through sensitivity analysis and comparative evaluation. This research is expected to provide valuable insights for the scientific management of the impacts of subway tunnel construction on nearby structures.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251320350"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on the molecular mechanism of cardiac protection of procarboxylpeptidase in MIRI rats based on the NLRP3 signaling pathway.","authors":"Luxiao He, Youfa Qin, Qiuping Lu, Ye Luo","doi":"10.1177/00368504251322085","DOIUrl":"10.1177/00368504251322085","url":null,"abstract":"<p><p>ObjectiveTo investigate the way in which prolylcarboxypeptidase (PRCP) protects against myocardial ischemia-reperfusion injury (MIRI) and the mechanisms that underlie it.MethodA surgical ligation of the coronary artery was adopted to establish a myocardial ischemia-reperfusion model in male SD rats. Thirty-six rats were randomly divided into six groups: Normal group, Sham group, MIRI model group, empty vector (MIRI + EZ.null) group, PRCP overexpression (MIRI + PRCP) group, and nicorandil (MIRI + Nic) group, with 6 rats in each group. The rats received an injection of PRCP's adeno-associated virus 9 (AAV9) through the tail vein 3 weeks prior to the modeling.ResultsCompared with the Normal and Sham groups, the expression levels of NOD-like receptor thermal protein domain-associated protein 3 (NLRP3), Caspase-1, IL-18, IL-1β, and GSDMD in the MIRI group and MIRI + EZ-null group were significantly increased (<i>P</i> < 0.05). Myocardial apoptosis index, myocardial infarction size, ejection fraction, and short axis shortening rate were significantly increased (<i>P</i> < 0.05). At the same time, PRCP and nicorandil therapy could reverse the damage effect caused by MIRI (<i>P</i> < 0.05).ConclusionPRCP can lessen MIRI and protect cardiac function in rats by inhibiting NLRP3/Capase-1/IL-18/IL-1β signaling pathway-mediated cell pyroptosis.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251322085"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid dual-area power grid frequency fluctuation effective control utilizing a maiden combination of MOA-based 1 + PIID and PD^μF^λ controllers.","authors":"Kareem M AboRas, Ahmed Ma Sedik, Muhammad R Hammad","doi":"10.1177/00368504251330521","DOIUrl":"10.1177/00368504251330521","url":null,"abstract":"<p><p>Current power networks face considerable issues due to a continuous decrease in inertia and increased sensitivity to load/generation fluctuations. The main cause of these problems is the enhanced penetration capabilities of renewable energy sources. An unbalanced load with high power output greatly affects the frequency behavior of electrical grids. Several load-frequency control mechanisms are commonly employed to tackle these problems. Accordingly, the purpose of this work is to present a novel optimal load frequency control methodology for dual-area-linked power systems that contain a variety of conventional (i.e. thermal generator) and renewable (i.e. solar photovoltaic plant) power sources. A revolutionary hybrid regulator, the one plus proportional integral double-integral derivative with a proportional fractional derivative with fractional filter (1 + PIID-PD^μF^λ), has been designed. Its goal is to lessen frequency drifts brought on by any known load disturbance. The optimal gains of the 1 + PIID-PD^μF^λ controller are finely adjusted using the mother optimization algorithm, an up-to-date population-based metaheuristic optimization technique that simulates the procedure of birthing and growth. The mother optimization algorithm has demonstrated its superior performance compared to other brand-new optimization methods, including tuna swarm optimization and sea horse optimization. The effectiveness of the proposed mother optimization algorithm-based 1 + PIID-PD^μF^λ regulator is assessed by comparing its performance with other cascaded regulators in existing literature, such as TIDF-PID^μD, FOPI-PIDA, and PID-TID, which stand for tilt integral derivative with filter-proportional integral derivative fractional derivative with filter, proportional integral-proportional integral derivative acceleration, and proportional integral derivative-tilted integral derivative, respectively. Various scenarios involving fluctuations in load (step, multi-step, and random), solar radiation changes, and system parameter modifications are used to demonstrate the controller's effectiveness in handling disturbances. The simulation results, presented using MATLAB/SIMULINK, show that the proposed controller outperforms other existing controllers in terms of its dynamic response to system disturbances, namely it achieved a substantial reduction in frequency overshoot (94.66%, 48.49%, 68.75%), undershoot (94.66%, 26.75%, 67.25%), and settling time (78.57%, 90.81%, 75.0%) as measured by the frequency deviation in Area 1, respectively. Similar improvements were observed in frequency deviation in Area 2 and deviation in power exchange between system areas.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251330521"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miRNA profile in pancreatic neuroendocrine tumors: Preliminary results.","authors":"Oana A Ciobanu, Vlad Herlea, Elena Milanesi, Maria Dobre, Simona Fica","doi":"10.1177/00368504251326864","DOIUrl":"10.1177/00368504251326864","url":null,"abstract":"<p><strong>Objective: </strong>Our understanding of the pathophysiology of pancreatic neuroendocrine tumors (PanNETs) remains incomplete, largely due to their historically underestimated incidence and the perception of these tumors as rare and slow-growing cancers. Additionally, conventional reliance on histological examination alone is gradually being supplemented by the exploration and introduction of molecular biomarkers, such as microRNAs (miRNAs). As miRNAs modulate the expression of multiple genes and pathways involved in the tumorigenesis of PanNETs, these biomarkers hold considerable promise for diagnosis and prognosis applications. In this study, we aimed to identify miRNAs as tissue markers associated with the diagnosis of PanNETs.</p><p><strong>Methods: </strong>We conducted a case-control study including: 7 PanNETs and 19 nontumoral pancreatic tissues obtained from Romanian patients. The samples underwent miRNA profiling via quantitative RT-PCR to assess the expression of 84 miRNAs. Our results were compared with those obtained by reanalyzing a public dataset. Furthermore, we structured our miRNA expression data according to their targeted mRNAs and their roles in signaling pathways.</p><p><strong>Results: </strong>Fourteen miRNAs (miR-1, miR-133a-3p, miR-210-3p, miR-7-5p, miR-10a-5p, miR-92b-3p, miR-132-3p, miR-221-3p, miR-29b-3p, miR-107, miR-103a-3p, let-7b-5p, miR-148a-3p, and miR-202-3p) were identified as differentially expressed by comparing PanNETs with pancreatic nontumoral tissues, with six miRNAs (miR-7-5p, miR-92b-3p, miR-29b-3p, miR-107, miR-103a-3p, and miR-148a-3p) also found in the public dataset analyzed. Bioinformatic analysis revealed that the 14 identified miRNAs target 17 genes. Reanalyzing two public gene expression datasets, five of these genes have been found differentially expressed in PanNET compared to controls.</p><p><strong>Conclusions: </strong>Our preliminary results, albeit limited by a small sample size, highlighted a specific miRNA expression pattern able to distinguish tumoral from normal pancreatic tissue. The diagnostic performance of these miRNAs, matching with circulating miRNAs and validated in more homogeneous and large cohorts, could represent a starting point for improving the diagnostic accuracy of PanNETs.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251326864"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe phlebitis and cutaneous necrosis following peripheral administration of high-concentration potassium chloride: A case report and vascular access management implications.","authors":"Fang Li, Ting Wang, Ling Wang, Siyang Zhao, Yuanyuan Zhang, Yuetong Ren, Hui Li, Hong Jiang","doi":"10.1177/00368504251314081","DOIUrl":"10.1177/00368504251314081","url":null,"abstract":"<p><p>Electrolyte imbalance management is crucial in diverse clinical scenarios, with intravenous potassium repletion often required. High-concentration infusions can pose severe complications if extravasation occurs, leading to phlebitis, local tissue damage, or in severe cases, cutaneous necrosis. This risk is elevated in geriatric patients due to factors like reduced tissue elasticity and sensitivity. We report a case of phlebitis and skin necrosis in an elderly woman after peripheral KCl infusion (6% [800 mmol/L]). A woman in her early 70 s presented with obstructive jaundice and critically low potassium levels. A peripheral intravenous administration of 6% KCl was initiated to rectify hypokalemia. Due to superficial venous site selection and the patient's reduced sensitivity, phlebitis developed unnoticed, leading to cutaneous necrosis. Management involved medication discontinuation, cannula removal, application of a magnesium sulfate dressing, limb elevation, and a hydrogel dressing. Despite initial necrosis, wound debridement, ongoing dressings, and moderate hand exercises led to a complete wound resolution. This case underscores the importance of careful selection and monitoring of infusion sites during administration of irritant solutions like concentrated KCl, particularly in geriatric patients. Patient-specific factors, pharmacological implications, and the necessity for adequate vascular assessment are emphasized. Further, the case highlights the necessity for prompt and multifaceted management strategies to handle complications, including patient and caregiver education, careful wound management, and proactive nursing care. The event underscores the need for established protocols regarding the administration of high-risk drugs to prevent severe sequelae.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251314081"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sinonasal extramedullary plasmacytoma: A case report and review of the literature.","authors":"Desderius Chussi, Kenneth Mlay, Ezekiel G Karuga, Elifaraja Naman, Philbert Mtenga, Peter Shija, Alex Mremi","doi":"10.1177/00368504241312434","DOIUrl":"10.1177/00368504241312434","url":null,"abstract":"<p><p>Primary solitary extramedullary plasmacytoma is a malignant neoplasm characterized by the monoclonal proliferation of plasma cells outside the bone marrow. The tumor rarely occurs in the sinonasal tract, accounting for about 4% of all non-epithelial sinonasal tumors. Herein, the authors describe a rare case of sinonasal extramedullary plasmacytoma in a 33-year-old man who presented with a 3-month history of progressively increasing nasal mass, causing obstruction. A CT scan showed a soft tissue mass measuring 5*8*3 cm in the right and left nasal cavities, obstructing the nasal airway. The mass extended to the right maxillary sinus. Histopathology and immunohistochemical tests confirmed it to be plasmacytoma. Lymphomas with prominent plasmacytic differentiation and multiple myeloma workups were negative. The patient initially refused treatment. After counseling, the patient consented to undergo surgery and later radiotherapy treatment. At one-year follow-up, the patient is disease-free with no signs of recurrence. Plasmacytomas are either medullary or extramedullary neoplasms. The latter are extremely rare tumors, more commonly presenting in the submucosal tissue of the upper respiratory tract. A mass or swelling causing nasal or pharyngeal symptoms is by far the most common presentation of this entity in the head and neck region. Because these lesions are radiosensitive, radiotherapy is a recommended treatment approach. Further studies are needed to better understand the prognosis and effective treatment regimens.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241312434"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}