综合性期刊最新文献

{"title":"John Gurdon obituary: Biologist who made cloning possible.","authors":"Ron Laskey","doi":"10.1038/d41586-025-03418-5","DOIUrl":"https://doi.org/10.1038/d41586-025-03418-5","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"55 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence coupled to pharmacometrics modelling to tailor malaria and tuberculosis treatment in Africa.","authors":"Gemma Turon,Mwila Mulubwa,Anna Montaner,Mathew Njoroge,Kelly Chibale,Miquel Duran-Frigola","doi":"10.1038/s41467-025-64304-2","DOIUrl":"https://doi.org/10.1038/s41467-025-64304-2","url":null,"abstract":"Africa's vast genetic diversity poses challenges for optimising drug treatments in the continent, which is exacerbated by the fact that drug discovery and development efforts have historically been performed outside Africa. This has led to suboptimal therapeutic outcomes in African populations and overall scarcity of relevant pharmacogenetic data, including characteristic genotypes as well as drugs prescribed in the continent to treat infectious diseases. Here, we propose a general approach to identify drug-gene pairs with potential pharmacogenetic interest. Our pipeline couples machine learning and artificial intelligence with physiologically-based pharmacokinetic (PBPK) and non-linear mixed effects (NLME) modelling to hypothesize which pharmacogenes could be of potential clinical interest, and which dose adjustments could be made to provide better treatment outcomes for African populations. Drug-gene pairs are first ranked with the latest knowledge embedding techniques, based on public structural and bioactivity data for drugs and genes, followed by a large language model-based refinement. Selected genes are then evaluated for their sensitivity in PBPK analysis, and relevant variants subsequently inspected with NLME for dose optimization. The analysis is focused on genes with potential clinical relevance in Africa. We delve deeper into malaria and tuberculosis therapies, many of which remain uncharacterised from a pharmacogenetic perspective.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":"9258"},"PeriodicalIF":16.6,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mosquito salivary sialokinin reduces monocyte activation and chikungunya virus-induced inflammation via neurokinin receptors.","authors":"Siew-Wai Fong,Jeslin J L Tan,Vaishnavi Sridhar,Siti Naqiah Amrun,Vanessa K X Neo,Nathan Wong,Bernett Lee,Yi-Hao Chan,Anthony Torres-Ruesta,Liang Hui Loo,Anna X Y Loo,Sarah K W Tan,Rhonda S L Chee,Tze-Kwang Chua,Angeline Rouers,Guillaume Carissimo,Fok-Moon Lum,Yee-Sin Leo,Laurent Renia,R Manjunatha Kini,Lisa F P Ng","doi":"10.1038/s41467-025-64468-x","DOIUrl":"https://doi.org/10.1038/s41467-025-64468-x","url":null,"abstract":"Global warming is expanding mosquito habitats and increasing mosquito-borne diseases. In tropical and sub-tropical regions, chikungunya virus (CHIKV) transmitted by Aedes mosquitoes has become a major concern due to the debilitating chronic joint disease it causes. Mosquito saliva contains bioactive factors that enhance viral infection, with sialokinin identified as a key contributor to vascular leakage and viral spread in mice. Here, we demonstrate that sialokinin binds to neurokinin receptors and restricts the activation of human myeloid cells. Mechanistically, sialokinin facilitates early viral dissemination, as evidenced by increased viral load in the contralateral footpad at 1 day post-infection, and significantly reduces circulating CD169+ monocytes while suppressing IFN-γ-producing T-cell-driven inflammation, as reflected by reduced joint footpad swelling in female CHIKV-infected mice. Clinically, patients with severe CHIKV disease exhibited higher levels of IgG antibodies against sialokinin, which correlated with higher viral loads and systemic inflammatory markers. Our findings highlight the multifaceted role of sialokinin in facilitating early viral dissemination and modulating host immunity during CHIKV infection. Given the growing threat of mosquito-borne diseases in a warming, disease-burdened world, targeting mosquito salivary factors like sialokinin could offer a novel therapeutic strategy to mitigate viral-induced inflammation and improve clinical outcomes.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"53 1","pages":"8644"},"PeriodicalIF":16.6,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal plasma cell-free RNA as a predictor of early and late-onset preeclampsia throughout pregnancy.","authors":"Nerea Castillo-Marco,Teresa Cordero,Marina Igual,Irene Muñoz-Blat,Carla Gómez-Álvarez,Neus Bernat-González,Ángela Gaspar-Doménech,Érika Ortiz-Domingo,Alba Vives,Sheila Ortega-Sanchís,Rogelio Monfort-Ortiz,Petr Volkov,Juan Luis Delgado,Laura Hernandez-Hernandez,Esther Canovas,Maria Del Mar Gil,Belén Santacruz,Nieves Luisa Gonzalez-Gonzalez,Walter Plasencia,Alfredo Perales-Marín,Beatriz Marcos-Puig,Ana María Palacios-Marqués,Íñigo Melchor,Alicia Martin-Martinez,Taysa Benitez-Delgado, ,Carlos Simón,Tamara Garrido-Gómez","doi":"10.1038/s41467-025-64215-2","DOIUrl":"https://doi.org/10.1038/s41467-025-64215-2","url":null,"abstract":"Early- and late-onset preeclampsia (EOPE and LOPE) pose serious maternal-fetal risks, yet non-invasive early prediction remains challenging. In a prospective cohort of 9,586 pregnancies, we analyze trimester-specific plasma cell-free RNA (cfRNA) profiles from 42 EOPE and 43 LOPE cases versus 131 normotensive controls. Organ-specific transcriptomic shifts distinguish EOPE from LOPE. Predictive models based on cfRNA signatures identify EOPE up to 18.0 weeks before clinical onset in the first-trimester (T1) (AUC = 0.88), and 8.5 weeks in the second trimester (T2) (AUC = 0.89). LOPE is predicted 14.9 weeks in advance using T2 data (AUC = 0.90), while T1 performance is lower (AUC = 0.68). External validation confirms robust EOPE prediction (AUC = 0.87 at T1; 0.81 at T2) and acceptable LOPE performance (AUC = 0.63 at T1; AUC = 0.77 at T2). EOPE models are enriched for decidual transcripts, suggesting early maternal involvement; LOPE models reflect broader tissue contributions. These findings offer a path to early, non-invasive, subtype-specific preeclampsia risk stratification and prevention.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"54 1","pages":"9208"},"PeriodicalIF":16.6,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"People with blindness can read again after retinal implant.","authors":"Liam Drew","doi":"10.1038/d41586-025-03420-x","DOIUrl":"https://doi.org/10.1038/d41586-025-03420-x","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"18 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What's the cap on human energy expenditure? Elite athletes reveal 'metabolic ceiling'.","authors":"Mohana Basu","doi":"10.1038/d41586-025-03389-7","DOIUrl":"https://doi.org/10.1038/d41586-025-03389-7","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"1 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Signal-strapping as a protein-sequence search method for the discovery of metalloproteins.","authors":"João Paulo L Franco Cairo,Thamy L R Corrêa,Wendy A Offen,Alison K Nairn,Julia Walton,Sean T Sweeney,Gideon J Davies,Paul H Walton","doi":"10.1038/s41467-025-64309-x","DOIUrl":"https://doi.org/10.1038/s41467-025-64309-x","url":null,"abstract":"Metalloprotein discovery is often made post hoc, in which activity studies following protein isolation reveal a metal-ion dependence. Herein we take a different approach to finding metalloproteins, by building on the discovery of copper-containing lytic polysaccharide monooxygenases (LPMOs), which include an N-terminal histidine as part of their sequence. This residue acts as a natural chelator for transition metal ions, irrespective of the structure of the protein. We report the method of signal strapping, where sequences of N-terminal signal peptides artificially appended with a histidine residue at their C-terminus are used to bootstrap a proteomic search. These searches return sequences of proteins with an N-terminal histidine capable of coordinating a metal ion. We exemplify the approach by the discovery and characterisation of four classes of bacterial metalloproteins, including two that we denote as anglerases reflecting their potential to capture transition metal ions from the bacterial environment.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"72 1","pages":"9244"},"PeriodicalIF":16.6,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-range moiré tuning effect via inter-layer drag interaction.","authors":"Lijun Zhu,Xiaoqiang Liu,Xinyi Wan,Huijuan Dai,Zhenhua Qiao,Lin Li,Changgan Zeng","doi":"10.1038/s41467-025-64267-4","DOIUrl":"https://doi.org/10.1038/s41467-025-64267-4","url":null,"abstract":"Constructing moiré superlattices has been demonstrated to be a powerful approach for tailoring the electronic properties of two-dimensional van der Waals materials. However, the periodic moiré potential diminishes rapidly away from the interface between the two stacked layers, restricting the moiré modulation only at the superlattice interface. Here, we present an alternative strategy to extend the influence range of the moiré tuning through drag interaction, a dynamic process involving inter-layer momentum/energy transfer mediated by Coulomb scatterings. By fabricating a unique electronic double-layer structure comprising a graphene moiré superlattice and a pristine graphene layer, we observe several intriguing inter-layer drag behaviors dominated by moiré physics. Notably, measuring the drag voltage within the pristine graphene layer, located distant from the moiré superlattice, reveals clear moiré tuning effects on the drag signal, including self-similar mapping spectra and the Hofstadter's butterfly spectra of drag resistance in the presence of a magnetic field. The realization of such moiré drag effect thus establishes a new paradigm for remote moiré engineering, offering a gateway to explore rich moiré physics in the emerging two-dimensional systems.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"2 1","pages":"9253"},"PeriodicalIF":16.6,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145332011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Framework for Sensory-to-Memory Weighting During Navigation.","authors":"Nikita M Finger,Davi C Drieskens,Cynthia F Moss","doi":"10.1111/nyas.70112","DOIUrl":"https://doi.org/10.1111/nyas.70112","url":null,"abstract":"Navigation operates on the weighting of different sources of information to guide path selection. Although navigational strategies are commonly categorized as either sensory-driven or memory-based, real-world navigation typically involves dynamic interactions between immediate sensory information and stored spatial knowledge. Here, we propose a theoretical framework that conceptualizes navigation along a dynamic continuum between sensory and memory reliance, with working memory serving as the mediator in this process. Bats provide a powerful system to explore this sensory-to-memory continuum, given their use of vision, echolocation, and memory. Through active modulation of sonar signal parameters, bats adjust their sampling of environmental stimuli with respect to task demands and environmental contexts, providing a quantifiable measure of sensory acquisition. We surveyed the literature on bat sensing and navigation in the context of our framework and propose that navigational strategies encompass a fluid continuum whereby the relative weighting of sensory signals and spatial memory dynamically shifts with task demands, environmental context, learned experiences, and species-specific adaptations. These observations provide a foundation for a sensory-to-memory framework that may help guide investigations into bat navigation dynamics. We present this as a working model intended for refinement through future empirical testing across diverse bat species and potentially other taxa.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"98 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Decision-Making Mechanisms in Schizophrenia based on Dynamic Amplitude-Locked Value and Theta-Band Brain Network Analysis.","authors":"Shuman Huang,Jintao Yao,Wanru Li,Yichen Yao,Zhengwei Xu,Zhenmeng Zhao","doi":"10.1111/nyas.70098","DOIUrl":"https://doi.org/10.1111/nyas.70098","url":null,"abstract":"Schizophrenia is a severe psychiatric disorder that involves disrupted cognition, emotion, and behavior. Growing evidence links its pathophysiology to the impaired coupling of large-scale brain networks. Previous studies have shown that phase synchronization effectively maps functional connectivity in neuronal populations. However, amplitude-based approaches to constructing functional brain networks remain comparatively rare. To address this gap, this study employed the dynamic amplitude-locked value (DALV) method to construct functional connectivity networks from scalp electroencephalogram (EEG) signals and systematically analyzed abnormal neural oscillations of people with schizophrenia (PSZ, N = 46) and healthy controls (HC, N = 31). The experimental results showed that compared with HC: (1) P300 components were significantly elicited at the CPz and FCz electrode sites, with the amplitude markedly reduced in the PSZ. (2) The average power of the whole brain exhibited significantly increased activity in the theta frequency band (p < 0.001) in PSZ and increases within the theta band for the parietal, prefrontal, and left temporal regions. (3) The results of brain network analysis based on DALV showed that there was a significantly reduced node degree, clustering coefficient, local efficiency, and global efficiency of the network in PSZ.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"16 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145319269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}