综合性期刊最新文献

{"title":"Are screens harming teens? What scientists can do to find answers","authors":"","doi":"10.1038/d41586-025-00991-7","DOIUrl":"https://doi.org/10.1038/d41586-025-00991-7","url":null,"abstract":"The fierce debate about smartphones and adolescent mental health rests on conflicting science. Researchers and technology companies must work to improve it.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"28 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unicorn slippers in space","authors":"","doi":"10.1038/d41586-025-00950-2","DOIUrl":"https://doi.org/10.1038/d41586-025-00950-2","url":null,"abstract":"Avoidance tactics.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"67 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment","authors":"Susan S. Hoffman, Ziyin Tang, Anne Dunlop, Patricia A. Brennan, Thompson Huynh, Stephanie M. Eick, Dana B. Barr, Blake Rushing, Susan L. McRitchie, Susan Sumner, Kaitlin R. Taibl, Youran Tan, Parinya Panuwet, Grace E. Lee, Jasmin Eatman, Elizabeth J. Corwin, P. Barry Ryan, Dean P. Jones, Donghai Liang","doi":"10.1038/s41467-025-57273-z","DOIUrl":"https://doi.org/10.1038/s41467-025-57273-z","url":null,"abstract":"<p>We evaluated associations among exposure to prenatal phthalate metabolites, perturbations of the newborn metabolome, and infant neurobehavioral functioning in mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort during 2016–2018. We quantified eight phthalate metabolites in prenatal urine samples collected between 8- and 14-weeks’ (visit 1; <i>n</i> = 216) and 24- and 30-weeks’ gestation (visit 2; <i>n</i> = 145) and metabolite features in newborn dried-blood spot samples collected at delivery. Associations between phthalate metabolite concentrations and metabolic feature intensities at both visits were examined using adjusted generalized linear models (MWAS). Then, an exploratory meet-in-the-middle (MITM) analysis was conducted in a subset with NICU Neonatal Neurobehavioral Scale (NNNS) scores (visit 1 <i>n</i> = 81; visit 2 <i>n</i> = 71). In both the MWAS and MITM, many of the confirmed metabolites are involved in tyrosine and tryptophan metabolism, including tryptophan, tyrosine, thyroxine, and serine. This analysis elucidates how prenatal phthalate exposure disrupts the newborn metabolome and infant neurobehavioral outcomes.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"6 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical accuracy of closed-loop steady state in a zero-dimensional cardiovascular model.","authors":"Nick van Osta, Gitte van den Acker, Tim van Loon, Theo Arts, Tammo Delhaas, Joost Lumens","doi":"10.1098/rsta.2024.0208","DOIUrl":"https://doi.org/10.1098/rsta.2024.0208","url":null,"abstract":"<p><p>Closed-loop cardiovascular models are becoming vital tools in clinical settings, making their accuracy and reliability paramount. While these models rely heavily on steady-state simulations, accuracy because of steady-state convergence is often assumed negligible. Using a reduced-order cardiovascular model created with the CircAdapt framework as a case study, we investigated steady-state convergence behaviour across various integration methods and simulation protocols. To minimize the effect of numerical errors, we first quantified the numerical errors originating from integration methods and model assumptions. We subsequently investigate this steady-state convergence error under two distinct conditions: first without, and then with homeostatic pressure-flow control (PFC), providing a comprehensive assessment of the CircAdapt framework's numerical stability and accuracy. Our results demonstrated that achieving a clinically accurate steady state required 7-15 heartbeats in simulations without regulatory mechanisms. When homeostatic control mechanisms were included to regulate mean arterial pressure and blood volume, more than twice the number of heartbeats was needed. By simulating a variable number of heartbeats tailored to each simulation's characteristics, an efficient balance between computational cost and steady-state accuracy can be achieved. Understanding this balance is crucial as cardiovascular models progress towards clinical use.This article is part of the theme issue 'Uncertainty quantification for healthcare and biological systems (Part 2)'.</p>","PeriodicalId":19879,"journal":{"name":"Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences","volume":"383 2293","pages":"20240208"},"PeriodicalIF":4.3,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coassembly of hybrid microscale biomatter for robust, water-processable, and sustainable bioplastics","authors":"Yijin Qiu,&nbsp;Dachuan Zhang,&nbsp;Min Long,&nbsp;Zhixuan Zhou,&nbsp;Changdan Gao,&nbsp;Shuai Ma,&nbsp;Jinfa Qin,&nbsp;Kaijuan Chen,&nbsp;Chaoji Chen,&nbsp;Ze Zhao,&nbsp;Hongbing Deng","doi":"10.1126/sciadv.adr1596","DOIUrl":"10.1126/sciadv.adr1596","url":null,"abstract":"<div >Unlike conventional methods that typically involve extracting biopolymers/monomers from biomass using lots of hazardous chemicals and high energy, the direct utilization of biological matter (biomatter) without extraction offers a more sustainable alternative for bioplastic production. However, it often suffers from insufficient mechanical performances or limited processabilities. Herein, we proposed a hybrid microscale biomatter coassembly strategy that leverages the interactions between the inherent microarchitectures of waste cotton fiber and pollen particles. With minimal preprocessing, they form a castable slurry that can spontaneously organize into a dense fiber-laminate bioplastic network, exhibiting high mechanical properties (52.22 megapascals and 2.24 gigapascals) without using toxic organic chemicals or heavy machinery. The resulting bioplastic features controlled hydration-induced microstructural disassembly/reassembly, enabling water-based processability into complex, dynamic architectural systems. In addition, it demonstrates good biodegradability, closed-loop recyclability, and satisfactory environmental benefits, outperforming most common plastics. This study provides an instant nature-derived paradigm for bioplastics’ sustainable production, processing, and recycling, offering a promising solution for facilitating eco-friendly advanced applications.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 14","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr1596","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression","authors":"Rongtao Jiang,&nbsp;Paul Geha,&nbsp;Matthew Rosenblatt,&nbsp;Yunhe Wang,&nbsp;Zening Fu,&nbsp;Maya Foster,&nbsp;Wei Dai,&nbsp;Vince D. Calhoun,&nbsp;Jing Sui,&nbsp;Marisa N. Spann,&nbsp;Dustin Scheinost","doi":"10.1126/sciadv.adt1083","DOIUrl":"10.1126/sciadv.adt1083","url":null,"abstract":"<div >Chronic pain conditions frequently coexist and share common genetic vulnerabilities. Despite evidence showing associations between pain and depression, the additive effect of co-occurring pain conditions on depression risk and the underlying mechanisms remain unclear. Leveraging data from 431,038 UK Biobank participants with 14-year follow-up, we found a significantly increased risk of depression incidence in individuals reporting pain, irrespective of body site or duration (acute or chronic), compared with pain-free individuals. The depression risk increased with the number of co-occurring pain sites. Mendelian randomization supported potential causal inference. We constructed a composite pain score by combining individual effects of acute or chronic pain conditions across eight body sites in a weighted manner. We found that depression risks increased monotonically in parallel with composite pain scores. Moreover, some inflammatory markers, including C-reactive protein, partially mediated the association between composite pain scores and depression risk. Considering the high prevalence of comorbid depression and pain, pain screening may help identify high-risk individuals for depression.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 14","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt1083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial dipeptidyl peptidases of the S9B family as host-microbe isozymes","authors":"Mashael R. Aljumaah,&nbsp;Jeffery Roach,&nbsp;Yunan Hu,&nbsp;John Gunstad,&nbsp;M. Andrea Azcarate-Peril","doi":"10.1126/sciadv.ads5721","DOIUrl":"10.1126/sciadv.ads5721","url":null,"abstract":"<div >Human dipeptidyl peptidase 4 (hDPP-4) has been a pharmacological target for metabolic diseases, particularly diabetes, since the early 2000s. As a ubiquitous enzyme found in both prokaryotic and eukaryotic organisms, hDPP-4 plays crucial roles in host homeostasis and disease progression. While many studies have explored hDPP-4’s properties, research on gut microbially derived DPP-4 (mDPP-4) remains limited. This review discusses the significance of mDPP-4 and its health implications, analyzing crystal structures of mDPP-4 in comparison to human counterparts. We examine how hDPP-4 inhibitors could influence gut microbiome composition and mDPP-4 activity. Additionally, this review connects ongoing discussions regarding DPP-4 substrate specificity and potential access routes for mDPP-4, emphasizing the urgent need for further research on mDPP-4’s role in health and improve the precision of DPP-4 inhibitor therapies.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 14","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads5721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ligand spin immobilization in metal-organic frameworks enables high-performance chemispintronic detection of radical gas molecules","authors":"Cheng Liu,&nbsp;Xiao-Cheng Zhou,&nbsp;Guoao Li,&nbsp;Jian Su,&nbsp;Lingyu Tang,&nbsp;Qinglong Liu,&nbsp;Xiao Han,&nbsp;Sen Lv,&nbsp;Zhangyan Mu,&nbsp;Yamei Sun,&nbsp;Shuai Yuan,&nbsp;Fei Gao,&nbsp;Jing-Lin Zuo,&nbsp;Shuhua Li,&nbsp;Mengning Ding","doi":"10.1126/sciadv.adq3554","DOIUrl":"10.1126/sciadv.adq3554","url":null,"abstract":"<div >The precise quantification of gaseous radicals in exhaled breath, such as fractional exhaled nitric oxide, serves as an invaluable noninvasive clinical diagnosis particularly in discerning various respiratory disorders. To date, the development of high-performance nitric oxide sensors compatible to modern electronic devices remains fundamentally challenging. We report that metal-organic frameworks (MOFs) with ligand spin immobilization demonstrate superior chemispintronic sensitivity and selectivity toward nitric oxide. Tetrathiafulvalene radical cations (TTF·⁺) within the MOF lattice considerably enhance the nitric oxide recognition via spin exchange interactions, leading to a five–order of magnitude reduction in the limit of detection (LOD), as compared to volatile organic compounds (VOCs) via carrier-doping mechanism. Record-low LOD of 0.12 parts per billion was achieved in M-TTF-spin (M = cobalt, zinc, and cadmium) MOFs, which also demonstrates exceptional selectivity over typical nitrogen oxides (NO<i>_x</i>) and VOCs. This work opens up a distinct sensing platform for radical-like analytes through strategic design of spin-immobilized molecular functional motifs toward the spintronic device configurations.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 14","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adq3554","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuning catalyst-support interactions enable steering of electrochemical CO2 reduction pathways","authors":"Meng Wang,&nbsp;Yuke Li,&nbsp;Jinfeng Jia,&nbsp;Tanmay Ghosh,&nbsp;Ping Luo,&nbsp;Yu-Jhih Shen,&nbsp;Sibo Wang,&nbsp;Jiguang Zhang,&nbsp;Shibo Xi,&nbsp;Ziyu Mi,&nbsp;Mingsheng Zhang,&nbsp;Wan Ru Leow,&nbsp;Bernt Johannessen,&nbsp;Zainul Aabdin,&nbsp;Sung-Fu Hung,&nbsp;Jia Zhang,&nbsp;Yanwei Lum","doi":"10.1126/sciadv.ado5000","DOIUrl":"10.1126/sciadv.ado5000","url":null,"abstract":"<div >Tuning of catalyst-support interactions potentially offers a powerful means to control activity. However, rational design of the catalyst support is challenged by a lack of clear property-activity relationships. Here, we uncover how the electronegativity of a support influences reaction pathways in electrochemical CO₂ reduction. This was achieved by creating a model system consisting of Cu nanoparticles hosted on a series of carbon supports, each with a different heteroatom dopant of varying electronegativity. Notably, we discovered that dopants with high electronegativity reduce the electron density on Cu and induce a selectivity shift toward multicarbon (C₂₊) products. With this design principle, we built a composite Cu and F-doped carbon catalyst that achieves a C₂₊ Faradaic efficiency of 82.5% at 400 mA cm⁻², with stable performance for 44 hours. Using simulated flue gas, the catalyst attains a C₂₊ FE of 27.3%, which is a factor of 5.3 times higher than a reference Cu catalyst.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 14","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ado5000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic insights into evolution of parthenogenesis and triploidy in the flowerpot snake","authors":"Yunyun Lv,&nbsp;Wei Wu,&nbsp;Jin-Long Ren,&nbsp;Matthew K. Fujita,&nbsp;Menghuan Song,&nbsp;Zeng Wang,&nbsp;Ke Jiang,&nbsp;Dechun Jiang,&nbsp;Chaochao Yan,&nbsp;Changjun Peng,&nbsp;Zhongliang Peng,&nbsp;Jia-Tang Li","doi":"10.1126/sciadv.adt6477","DOIUrl":"10.1126/sciadv.adt6477","url":null,"abstract":"<div >The flowerpot snake (<i>Indotyphlops braminus</i>) is the only known parthenogenetic and triploid species within Serpentes. However, the genetic basis underlying this phenomenon remains unresolved. We investigated the genomic complexities of this rare all-female triploid reptile. On the basis of the newly assembled genome, we revealed 40 chromosomes grouped into three subgenomes (A, B, and C). Comparative genomic analysis with related diploid species revealed a chromosome fusion event in ancestral genomes. This event shaped the unique genetic landscape of the flowerpot snake. We examined gene expression specificity in ovarian tissues and identified pathways essential for DNA replication and repair. Our findings suggest a potential mechanism of homologous chromosome pairing during meiosis in allopolyploid parthenogenesis. This research provides insights into the evolutionary adaptations and genetic mechanisms underlying parthenogenesis in reptilian species, challenging traditional views on reproductive strategies and genomic evolution in asexual organisms.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 14","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt6477","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}