综合性期刊最新文献

{"title":"Psychometric properties and norm values of a short screening version of the profile of mood states POMS from the German general population.","authors":"Katja Petrowski, Monika Bjelopavlovic, Markus Zenger, Elmar Brähler, Bjarne Schmalbach","doi":"10.1038/s41598-025-07388-6","DOIUrl":"https://doi.org/10.1038/s41598-025-07388-6","url":null,"abstract":"<p><p>The current study aimed to provide further evidence of the structural validity of the 16-item-short version of the Profile of Mood States (POMS), a widely-used tool for assessing an individual's emotional state. This is significant for various research inquiries in clinical and social psychology. In order to cross-validate previous findings, an additional evaluation of the factorial structure and the psychometric properties is necessary in a newly collected dataset. A representative sample for age and gender of N = 2503 with 1329 (53%) female, 1173 (47%) male, and 1 (< 1%) diverse, with a mean age of M = 46 (SD = 18) was collected. The model fit for the four-factor model was acceptable, with good reliability for all factors. We found evidence for (partial) strict invariance between gender and age groups. There were small to moderate group differences for the Anger and Vigor subscales regarding age. We report normative percentile ranks. Our findings suggest that the POMS-16 is a dependable and structurally valid gauge of mood states. Especially in situations where a brief and cost-effective assessment is preferred, the POMS-16 should be a considered option.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"23889"},"PeriodicalIF":3.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sperm metabolomic signatures of asthenozoospermia and teratozoospermia in Chinese reproductive-age men.","authors":"Youzhu Li, Zhonghua Lu, Jingu Li, Ling Cheng, Yuanyuan Ye, Song Xu, Junfeng Tan, Lifeng Zheng, Huiyi Xie, Qisheng Zhong, Jiaqi Liu, Yunfan Yang, Rui Guo, Guoshi Liu","doi":"10.1038/s41598-025-09787-1","DOIUrl":"https://doi.org/10.1038/s41598-025-09787-1","url":null,"abstract":"<p><p>Asthenozoospermia and teratozoospermia are common causes of male infertility. Despite their prevalence, the underlying metabolic mechanisms remain poorly understood. In this study, we conducted targeted metabolomic profiling of sperm samples from 131 Chinese reproductive-age men (48 normozoospermic controls, 40 asthenozoospermic patients, and 43 teratozoospermic patients) to identify distinct metabolic signatures associated with these conditions. We identified 47 significantly altered metabolites in asthenozoospermia compared to normozoospermia (18 downregulated and 29 upregulated). In teratozoospermia, 25 metabolites showed significant changes compared to normozoospermia (10 downregulated, 15 upregulated). These differential metabolites, along with others identified through machine learning as relevant, are implicated in key pathways including energy metabolism, lipid metabolism, and amino acid metabolism. Alterations, such as those in corticosterone and hypoxanthine, suggest potential impacts on redox balance and stress responses. Using machine learning approaches, we developed diagnostic models for asthenozoospermia and teratozoospermia diagnosis, with the Glmnet model showing strong performance (AUC = 0.99 for asthenozoospermia, AUC = 0.9997 for teratozoospermia), although these results require external validation. Two metabolites emerged as candidate diagnostic biomarkers: corticosterone reveals common metabolic disturbances in both pathological conditions, and arachidate specifically indicates impaired lipid metabolism in asthenozoospermia. These findings improve our understanding of the metabolic basis of sperm dysfunction, and highlight the potential of sperm metabolomics as a powerful tool for diagnosing and managing male infertility.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"23932"},"PeriodicalIF":3.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids","authors":"Sean J. Miller,&nbsp;Rahul M. Dhodapkar,&nbsp;Hande Eda Sutova,&nbsp;Yao Xue,&nbsp;Seunghoon Lee,&nbsp;Robert Logan,&nbsp;Chongzhao Ran,&nbsp;Sagar Bhatta,&nbsp;Ashley Gomm,&nbsp;In Gyoung Ju,&nbsp;Michael Heyang,&nbsp;Rayyan Y. Darji,&nbsp;Marcello DiStasio,&nbsp;Rudolph E. Tanzi,&nbsp;Can Zhang,&nbsp;Z. Jimmy Zhou,&nbsp;Brian P. Hafler","doi":"10.1126/sciadv.ads5006","DOIUrl":"10.1126/sciadv.ads5006","url":null,"abstract":"<div >While the etiology of Alzheimer’s disease remains unknown, there is growing support for the amyloid-β antimicrobial hypothesis. Amyloid-β, the main component of amyloid plaques in Alzheimer’s disease, has been shown to be generated in the presence of microbes. Entrapment of microbes by aggregated amyloid-β may serve as an innate immune response to pathogenic infections. To understand the association of amyloid-β plaques and pathogenic infections in the central nervous system, we obtained viable short-interval postmortem human retinal tissue and generated human retinal organoids that contain electrophysiologically active neurons. Here, we demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces amyloid-β extracellular protein aggregates in human retinal explants and retinal organoids. Last, pharmacological inhibition of neuropilin-1 resulted in reduced amyloid-β deposition in human retinal explants treated with SARS-CoV-2 Spike 1 protein. These results suggest that Spike 1 protein, during infection with SARS-CoV-2, can induce amyloid-β aggregation, which may be associated with the neurological symptoms experienced in COVID-19.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads5006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonreciprocal transport in a room-temperature chiral magnet","authors":"Daisuke Nakamura,&nbsp;Mu-Kun Lee,&nbsp;Kosuke Karube,&nbsp;Masahito Mochizuki,&nbsp;Naoto Nagaosa,&nbsp;Yoshinori Tokura,&nbsp;Yasujiro Taguchi","doi":"10.1126/sciadv.adw8023","DOIUrl":"10.1126/sciadv.adw8023","url":null,"abstract":"<div >Chiral magnets under broken time-reversal symmetry can give rise to rectification of moving electrons, called nonreciprocal transport. Several mechanisms, such as the spin fluctuation–induced chiral scattering and asymmetry in the electronic band dispersion with and without the relativistic spin-orbit interaction, have been proposed, but clear identification and theoretical description of these different contributions are desired for full understanding of nonreciprocal transport phenomena. Here, we investigate a chiral magnet Co₈Zn₉Mn₃ and find the nonreciprocal transport phenomena consisting of different contributions with distinct field and temperature dependence across the magnetic phase diagram over a wide temperature range including above room temperature. We successfully separate the nonreciprocal resistivity into different components and identify their mechanisms as spin fluctuation–induced chiral scattering and band asymmetry in a single material with the help of theoretical calculations.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw8023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultracompact 3D integrated photonic chip for high-fidelity high-dimensional quantum gates","authors":"Kangrui Wang,&nbsp;Dawei Lyu,&nbsp;Chengkun Cai,&nbsp;Tianhao Fu,&nbsp;Jue Wang,&nbsp;Qianke Wang,&nbsp;Jun Liu,&nbsp;Jian Wang","doi":"10.1126/sciadv.adv5718","DOIUrl":"10.1126/sciadv.adv5718","url":null,"abstract":"<div >Spatial modes of photons offer a rich encoding resource for high-dimensional quantum information processing. Multiplane light conversion (MPLC) enables spatial mode transformation and is applicable in both classical and quantum optics. Here, we demonstrate a polymer-based MPLC device, fabricated via femtosecond laser three-dimensional printing, that realizes high-dimensional quantum logic gates in an ultracompact format. Specifically, we design a three-dimensional Hadamard gate by training a diffractive neural network to generate the required phase distribution. The device is evaluated through quantum process tomography at the single-photon level within spatial modes, achieving a fidelity of 90%. Compared to traditional spatial light modulator–based implementations, our approach integrates spatial mode manipulation into a miniaturized photonic platform. These results highlight the feasibility of polymer-based MPLC for compact quantum logic and open possibilities for scalable, high-dimensional quantum information processing on integrated photonic chips.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv5718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for the Research Article “Near-infrared light-triggered NO release for spinal cord injury repair” by Y. Jiang et al.","authors":"","doi":"10.1126/sciadv.adz6504","DOIUrl":"10.1126/sciadv.adz6504","url":null,"abstract":"","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"China pours money into brain chips that give paralysed people more control.","authors":"Smriti Mallapaty","doi":"10.1038/d41586-025-02098-5","DOIUrl":"https://doi.org/10.1038/d41586-025-02098-5","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":50.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: NUPR1 is a critical repressor of ferroptosis.","authors":"Jiao Liu, Xinxin Song, Feimei Kuang, Qiuhong Zhang, Yangchun Xie, Rui Kang, Guido Kroemer, Daolin Tang","doi":"10.1038/s41467-025-61573-9","DOIUrl":"https://doi.org/10.1038/s41467-025-61573-9","url":null,"abstract":"","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"6175"},"PeriodicalIF":14.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LMCT-driven electron relay unlocks alcohols as tunable reductants for nickel-catalyzed cross-electrophilic couplings.","authors":"Shun Wang, Weidi Zeng, Qing An, Lingfei Duan, Zhiwei Zuo","doi":"10.1038/s41467-025-61414-9","DOIUrl":"https://doi.org/10.1038/s41467-025-61414-9","url":null,"abstract":"<p><p>Photoinduced electron transfer is fundamental to both biological and synthetic processes; however, modulating back electron transfer (BET) remains a formidable challenge in achieving more efficient photocatalytic transformations. In this work, we present a strategy to regulate electron transfer dynamics via ligand-to-metal charge transfer (LMCT) catalysis, wherein the rapid β-scission of alkoxy radicals is harnessed to suppress BET, thereby facilitating the efficient transfer of reducing equivalents to drive transition metal-mediated reductive cross-coupling reactions. By strategically utilizing a diverse array of alcohol reductants, such as methanol and pinacol, we employ a cerium benzoate catalyst to enable reductive processes not through modulation of redox potentials, but by promoting synchronized electron transfer. Detailed mechanistic investigations reveal that the photoinduced electron relay process, governed by LMCT-BET, plays a pivotal role in effectively delivering reducing equivalents to catalytic sites, underscoring its significance in optimizing catalytic efficiency.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"6162"},"PeriodicalIF":14.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible switching of the environment-protected quantum spin Hall insulator bismuthene at the graphene/SiC interface.","authors":"Niclas Tilgner, Susanne Wolff, Serguei Soubatch, Tien-Lin Lee, Andres David Peña Unigarro, Sibylle Gemming, F Stefan Tautz, Thomas Seyller, Christian Kumpf, Fabian Göhler, Philip Schädlich","doi":"10.1038/s41467-025-60440-x","DOIUrl":"https://doi.org/10.1038/s41467-025-60440-x","url":null,"abstract":"<p><p>Quantum spin Hall insulators have been extensively studied both theoretically and experimentally because they exhibit robust helical edge states driven by spin-orbit coupling and offer the potential for applications in spintronics through dissipationless spin transport. Here we show that a single layer of elemental Bi, formed by intercalation of an epitaxial graphene buffer layer on SiC(0001), is a promising candidate for a quantum spin Hall insulator. This layer can be reversibly switched between an electronically inactive precursor state and a bismuthene state, the latter exhibiting the predicted band structure of a true two-dimensional bismuthene layer. Switching is accomplished by hydrogenation (dehydrogenation) of the sample. A partial passivation (activation) of Si dangling bonds causes a lateral shift of Bi atoms involving a change of the adsorption site. In the bismuthene state, the Bi honeycomb layer is a prospective quantum spin Hall insulator, inherently protected by the graphene sheet above and the H-passivated substrate below.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"6171"},"PeriodicalIF":14.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}