综合性期刊最新文献

{"title":"William S. Sly (1932-2025): A compassionate pioneer in biochemical genetics.","authors":"Mark S Sands,Jeffrey H Grubb,Carole A Vogler,Abdul Waheed,Adriana M Montaño","doi":"10.1073/pnas.2520590122","DOIUrl":"https://doi.org/10.1073/pnas.2520590122","url":null,"abstract":"William S. Sly, MD (1932-2025) was a biochemical geneticist who received his medical degree from Saint Louis University. He received additional training at the NIH with several members of the National Academy of Science and Nobel Prize winner Marshall Nirenberg. He is best known for discovering mucopolysaccharidosis type VII and developing a Food and Drug Administration-approved treatment for it. He served in several long-term leadership roles and won many accolades, including the Passano Foundation Award and induction into the National Academy of Sciences. Sly was equally well known as a kind and caring person who always made time for family, friends, colleagues, and patients. He is the personification of the caring and compassionate physician-scientist.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"15 1","pages":"e2520590122"},"PeriodicalIF":11.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria.","authors":"Alfonso Mendaña,María Santos-Merino,Raquel Gutiérrez-Lanza,Marina Domínguez-Quintero,Juan Manuel Medina-Méndez,Ana González-Guerra,Víctor Campa,Miguel Baez,Magaly Ducos-Galand,Rocío López-Igual,Daniel C Volke,Muriel Gugger,Pablo I Nikel,Didier Mazel,Fernando de la Cruz,Raúl Fernández-López","doi":"10.1073/pnas.2506928122","DOIUrl":"https://doi.org/10.1073/pnas.2506928122","url":null,"abstract":"Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature, but how this anticipatory role promotes adaptation to different environments remains poorly understood. Here, we subjected the cyanobacterium Synechococcus elongatus PCC 7942 to a long-term evolution experiment under high light, high temperature, and elevated CO2 levels. After 1,200 generations, we obtained a strain exhibiting a 600% increase in growth rate. Whole-genome sequencing revealed three mutations fixed in the evolved population, two of which were sufficient to recapitulate the fast-growing phenotype in the wild type. A mutation in the promoter of the shikimate kinase aroK led to its overexpression, while a mutation in the central circadian regulator sasA disrupted both the phase and amplitude of the circadian rhythm. Changes in circadian control led to widespread perturbations in the transcriptome and metabolome. These included major shifts in the Calvin-Benson-Bassham cycle and glycogen storage dynamics. While these changes increased fitness under the experimental conditions, they caused maladaptation when light or CO2 levels were altered, revealing a trade-off between fitness and environmental flexibility. Our results demonstrate that mutations in circadian control can drive fast adaptation by modulating central metabolism, underscoring the circadian cycle as a cornerstone of cellular plasticity. Thus, targeting the circadian cycle could be key to engineering cyanobacterial strains optimized for carbon fixation and biomass production.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"12 1","pages":"e2506928122"},"PeriodicalIF":11.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-printed micro ion trap technology for quantum information applications","authors":"Shuqi Xu, Xiaoxing Xia, Qian Yu, Abhinav Parakh, Sumanta Khan, Eli Megidish, Bingran You, Boerge Hemmerling, Andrew Jayich, Kristin Beck, Juergen Biener, Hartmut Häffner","doi":"10.1038/s41586-025-09474-1","DOIUrl":"https://doi.org/10.1038/s41586-025-09474-1","url":null,"abstract":"<p>Trapped-ion applications, such as in quantum information processing¹, precision measurements^2,3,4,5, optical clocks⁶ and mass spectrometry⁷, rely on specialized high-performance ion traps. The last three of these applications typically use traditional machining to customize macroscopic 3D Paul traps⁸, whereas quantum information processing experiments usually rely on photolithographic techniques to miniaturize the traps and meet scalability requirements^9,10. Using photolithography, however, it is challenging to fabricate the complex 3D electrode structures required for optimal confinement. Here we demonstrate a high-resolution 3D printing technology based on two-photon polymerization (2PP)¹¹ that is capable of fabricating large arrays of high-performance miniaturized 3D traps. We show that 3D-printed ion traps combine the advantages, such as strong radial confinement, of traditionally machined 3D traps with on-chip miniaturization. We trap calcium ions in 3D-printed ion traps with radial trap frequencies ranging from 2 MHz to 24 MHz. The tight confinement eases ion cooling requirements and allows us to implement high-quality Rabi oscillations with Doppler cooling only. Also, we demonstrate a two-qubit gate with a Bell-state fidelity of 0.978 ± 0.012. With 3D printing technology, the design freedom is greatly expanded without sacrificing scalability and precision, so that ion trap geometries can be optimized for higher performance and better functionality.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"31 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prudent planetary limit for geologic carbon storage","authors":"Matthew J. Gidden,&nbsp;Siddharth Joshi,&nbsp;John J. Armitage,&nbsp;Alina-Berenice Christ,&nbsp;Miranda Boettcher,&nbsp;Elina Brutschin,&nbsp;Alexandre C. Köberle,&nbsp;Keywan Riahi,&nbsp;Hans Joachim Schellnhuber,&nbsp;Carl-Friedrich Schleussner,&nbsp;Joeri Rogelj","doi":"10.1038/s41586-025-09423-y","DOIUrl":"10.1038/s41586-025-09423-y","url":null,"abstract":"Geologically storing carbon is a key strategy for abating emissions from fossil fuels and durably removing carbon dioxide (CO2) from the atmosphere1,2. However, the storage potential is not unlimited3,4. Here we establish a prudent planetary limit of around 1,460 (1,290–2,710) Gt of CO2 storage through a risk-based, spatially explicit analysis of carbon storage in sedimentary basins. We show that only stringent near-term gross emissions reductions can lower the risk of breaching this limit before the year 2200. Fully using geologic storage for carbon removal caps the possible global temperature reduction to 0.7 °C (0.35–1.2 °C, including storage estimate and climate response uncertainty). The countries most robust to our risk assessment are current large-scale extractors of fossil resources. Treating carbon storage as a limited intergenerational resource has deep implications for national mitigation strategies and policy and requires making explicit decisions on priorities for storage use. A risk-based, spatially explicit analysis of carbon storage in sedimentary basins establishes a prudent planetary limit of around 1,460 Gt of geological carbon storage, which requires making explicit decisions on priorities for storage use.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"645 8079","pages":"124-132"},"PeriodicalIF":48.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41586-025-09423-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate change increases the interannual variance of summer crop yields globally through changes in temperature and water supply","authors":"Jonathan Proctor,&nbsp;Lucas Vargas Zeppetello,&nbsp;Duo Chan,&nbsp;Peter Huybers","doi":"10.1126/sciadv.ady3575","DOIUrl":"10.1126/sciadv.ady3575","url":null,"abstract":"<div >Year-to-year variance of agricultural productivity is an important determinant of food security. Previous global analyses described increased yield volatility from warming, but it has become increasingly clear that changes in water availability are also a key determinant of yields. Here, we provide the first global quantification of climate change impacts on maize, soybean, and sorghum yield variance due to changes in temperature and soil moisture. Pairing an empirical crop model with CMIP6 simulations indicates that changes in temperature and soil moisture increase interannual weather-induced yield variance by <span><math><mrow><mn>7</mn><mo> </mo><mtext>to</mtext><mo> </mo><mn>19</mn><mfrac><mo>%</mo><mrow><mo>°</mo><mi>C</mi></mrow></mfrac></mrow></math></span> across crops. This increase is driven roughly equally by previously quantified increased temperature stress variance, as well as by increased covariance between temperature and soil moisture stresses. Results using a simple land surface model are consistent with those using CMIP6 simulations in indicating that this increased covariance is driven by warmer air more quickly drying soils and by dry soils promoting greater warming.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ady3575","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flies evolved a shock-absorber tissue used during embryonic development.","authors":"Thibaut Brunet","doi":"10.1038/d41586-025-02532-8","DOIUrl":"https://doi.org/10.1038/d41586-025-02532-8","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"66 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resurfacing promotes antibacterial activity of a lipid A-binding nanobody.","authors":"Angela C O'Donnell,Xun Wang,Nikol Kadeřábková,Kyra E Groover,Bethany C Perez,Amanda Helms,Jennifer S Brodbelt,Despoina A I Mavridou,Bryan W Davies","doi":"10.1073/pnas.2509305122","DOIUrl":"https://doi.org/10.1073/pnas.2509305122","url":null,"abstract":"Nanobodies have been pursued as candidates for antimicrobial design due to their small size and versatile binding capacities, but direct antibacterial activity of a nanobody has yet to be described. Here, we employed a bacterial surface display platform to screen a synthetic library of nanobody variants for antimicrobial potential. We identified a candidate that binds the essential lipid A component of gram-negative lipopolysaccharide. Nonetheless, this nanobody required a weakened outer membrane to access its target and elicit its toxic activity. Borrowing from observations of innate immune proteins, we found that resurfacing nanobodies with positively charged residues enabled them to bind and perturb the gram-negative outer membrane, but this alone was not sufficient for toxic activity. However, when we resurface our lipid A-targeting nanobody, it gained the ability to disrupt the outer membrane and enact its antibacterial function against wild-type bacteria. This development of a dual-function nanobody that can reach and bind previously inaccessible gram-negative targets introduces a route for antimicrobial biologic advancement.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"104 1","pages":"e2509305122"},"PeriodicalIF":11.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144960191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-processed foods — it’s time for an improved definition","authors":"","doi":"10.1038/d41586-025-02750-0","DOIUrl":"10.1038/d41586-025-02750-0","url":null,"abstract":"The worst excesses of industrial food production must be reined in, while ensuring people have access to adequate calories. The worst excesses of industrial food production must be reined in, while ensuring people have access to adequate calories.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"645 8079","pages":"7-7"},"PeriodicalIF":48.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/d41586-025-02750-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinspired twist-hyperbolic metamaterial for impact buffering and self-powered real-time sensing in UAVs","authors":"Xujiang Chao,&nbsp;Haoteng Hu,&nbsp;Jianjie Lin,&nbsp;Xueyang Ge,&nbsp;Yajun Wang,&nbsp;Linjie Xie,&nbsp;Bofan Hu,&nbsp;Liang Meng,&nbsp;Shudong Yu,&nbsp;Fei Liang,&nbsp;Lehua Qi,&nbsp;Zhong Lin Wang","doi":"10.1126/sciadv.adw6179","DOIUrl":"10.1126/sciadv.adw6179","url":null,"abstract":"<div >Turbulence-induced vibrations pose substantial risks to aircraft structural integrity and flight stability, particularly in unmanned aerial vehicles (UAVs), where real-time impact monitoring and lightweight protection are critical. Here, we present a bioinspired twist-hyperbolic metamaterial (THM) integrated with a triboelectric nanogenerator (TENG) for simultaneously impact buffering and self-powered sensing. The THM-TENG protector exhibits tunable stiffness (40 to 4300 newtons per millimeter), ~70% impact energy absorption, and achieves a specific energy absorption of ~0.25 joules per gram at a weight of only 10 grams. Through triboelectrification, the protector converts mechanical energy into electrical signals, enabling real-time monitoring of impact loads up to 1000 newtons (≤5 hertz). Integrated with a microcontroller unit, wireless transmission, and alarm systems, THM-TENG demonstrates dual functionality in UAVs: mitigating vibration while providing real-time force monitoring, positioning, and early warning, all without external power sources. This work establishes a transformative framework for lightweight, multifunctional protective systems with applications in aerospace, robotics, and autonomous vehicles.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw6179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foraminifera as indicators of species invasion: Ammonia confertitesta in Long Island Sound","authors":"Eleanor J. Goetz,&nbsp;Pincelli M. Hull,&nbsp;Johan Varekamp,&nbsp;Ellen Thomas","doi":"10.1126/sciadv.adv9447","DOIUrl":"10.1126/sciadv.adv9447","url":null,"abstract":"<div >Resolving timing of the invasion of nonindigenous species is difficult in estuarine settings, due to their pervasive history of anthropogenic disturbance. Many non-native marine taxa are not documented until after they have become invasive, leaving questions about invasion timing (first introduction and lag period), geographic origin, vectors and pathways, and cause(s) of success. Foraminifera, unicellular, calcareous-shelled eukaryotes, offer a unique way of analyzing past ecosystem structure because their fossilized shells provide a window into the past, and small size and abundance enable us to document distribution over time in core samples. We use records of Foraminifera to document the timing and history of establishment of an invasive species (<i>Ammonia confertitesta</i>) in Long Island Sound, east of New York City (USA). <i>A. confertitesta</i> was rare from the mid-19th century but did not proliferate until the mid-1970s. We hypothesize that increasing propagule pressure from the rapid increase in global ship traffic and ballast water was the main factor for its success.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv9447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}