综合性期刊最新文献

{"title":"Foreign cultural norms are better accepted in the second language.","authors":"Jiehui Hu,Aina Casaponsa,Wanyu Zhang,Rafał Jończyk,Yan Jing Wu,Shan Gao,Guillaume Thierry","doi":"10.1111/nyas.15407","DOIUrl":"https://doi.org/10.1111/nyas.15407","url":null,"abstract":"Cultural diversity goes hand-in-hand with language variation. It is unknown however, whether using a second language influences one's disposition toward cultural concepts. Here, we show that bilinguals process violations of cultural norms differently depending on whether concepts are introduced in the native (L1) or the second (L2) language. Participants read sentences that were acceptable or not, independent of culture, or acceptable in one culture but not in the other. Culture-independent generic knowledge was integrated similarly across languages, as indexed by N400 modulations of event-related brain potentials, whereas statements conforming to British culture were better accepted by Chinese-English bilinguals when presented in L2 English than L1 Chinese. To our knowledge, these findings offer the first evidence for an effect of language of operation on cultural judgments in bilinguals. Functioning in a second language thus disposes one to be more tolerant toward foreign cultural values, which has important implications in a culturally diverse world.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"13 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing hibernation: Unlocking nature's secrets for advances in healthy aging, critical care, and space exploration.","authors":"Kelly L Drew,Vadim B Fedorov,Khrystyne N Duddleston,Øivind Tøien","doi":"10.1111/nyas.70013","DOIUrl":"https://doi.org/10.1111/nyas.70013","url":null,"abstract":"Aging poses one of the greatest biomedical challenges of our time, with rising rates of frailty, sarcopenia, and cognitive decline globally. Preserving muscle and brain health is central to maintaining independence and quality of life in aging populations. This commentary explores how hibernation research, rooted in comparative physiology, offers unprecedented opportunities for drug discovery and therapeutic innovation. Hibernating animals exhibit remarkable abilities to regulate metabolism, protect the brain and muscles from atrophy, and prevent cellular damage under extreme conditions. These adaptations could inform new strategies for muscle preservation during inactivity, neuroprotection, and targeted temperature management, as well as critical needs in aging, neurocritical care, and space medicine. The bidirectional relationship between muscle and brain health underscores the potential for hibernation-inspired therapies to address both sarcopenia and cognitive decline. Applying these insights to space medicine and critical care settings could lead to groundbreaking solutions for unmet medical needs. Just as GLP-1 agonists emerged from the study of Gila monster venom, focusing on nature's extreme survivors may reveal overlooked molecular targets for drug development. By harnessing these adaptations, we can advance biomimicry in medical research and inspire sustainable solutions for healthy aging, critical care, and space exploration-offering new hope for patients, clinicians, and policymakers.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"31 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time in-situ magnetization reprogramming for soft robotics.","authors":"Xianqiang Bao,Fan Wang,Jianhua Zhang,Mingtong Li,Shuaizhong Zhang,Ziyu Ren,Jiahe Liao,Yingbo Yan,Wenbin Kang,Rongjing Zhang,Zemin Liu,Tianlu Wang,Metin Sitti","doi":"10.1038/s41586-025-09459-0","DOIUrl":"https://doi.org/10.1038/s41586-025-09459-0","url":null,"abstract":"Magnetic soft robots offer considerable potential across various scenarios, such as biomedical applications and industrial tasks, due to their shape programmability and reconfigurability, safe interaction, and biocompatibility1-4. Despite recent advances, magnetic soft robots are still limited by the difficulties in reprogramming their required magnetization profiles in real time on the spot (in situ), which is essential for performing multiple functions or executing diverse tasks5,6. Here, we introduce a method for real-time, in situ magnetization reprogramming that enables the rearrangement and recombination of magnetic units to achieve diverse magnetization profiles. We explore the applications of this method in structures of varying dimensions, from one-dimensional (1D) tubes to three-dimensional (3D) frameworks, showcasing a diverse and expanded range of configurations and their deformations. This method also demonstrates versatility in diverse scenarios, including navigating around objects without undesired contact, reprogramming cilia arrays, managing multiple instruments cooperatively or independently under the same magnetic field, and manipulating objects of various shapes. These capabilities extend the range of applications for magnetic actuation technologies. Furthermore, this method emancipates magnetic soft robots from the sole reliance on external magnetic fields for shape change, facilitating unprecedented modes and varieties of deformation while simultaneously reducing the need for complex magnetic field generation systems; thereby, opening new avenues for the development of magnetic actuation technologies.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"58 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A supramolecular approach to improve the performance and operational stability of all-perovskite tandem solar cells.","authors":"Xinxin Lian,Mingjing Jin,Weideren Dai,Yuanjiang Lv,Ming Luo,Ying Hu,Zhijie Wang,Haiyun Li,Chunyu Xu,Dongrui Jiang,Hao Min,Yifan Chen,Jin Chang,Tzu-Sen Su,Fei Ma,Yang Bai,Hong Zhang,Xiaoliang Mo,Junhao Chu","doi":"10.1038/s41467-025-62391-9","DOIUrl":"https://doi.org/10.1038/s41467-025-62391-9","url":null,"abstract":"Wide-bandgap perovskite is pivotal as a photoactive layer in the top cell of prevailing tandem solar cells. However, the intrinsic instability of wide-bandgap perovskite solar cells is predominantly attributed to the vacancy defects caused by multiple ion migration. Here, we incorporate an ether ring super-molecule into perovskite. This supramolecular approach effectively manipulates the crystallization kinetics and suppresses the halide segregation under illumination by tuning the coordination of halides toward monovalent cations and lead ions. As a result, the supramolecular engineered 1.77 eV perovskite solar cells achieve a champion power conversion efficiency of 21.01% with an outstanding operational stability, retaining 95% of initial efficiency after 1000 h σof maximum-power-point tracking test. Meanwhile, the two-terminal all-perovskite tandem solar cells achieve the champion efficiency of 28.44% (certified 27.92%). This work paves an avenue to improve the film quality and illumination stability of mixed halide wide-bandgap perovskites with a supramolecular approach.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"58 1","pages":"7173"},"PeriodicalIF":16.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of substrate recognition and release of human SGLT2.","authors":"Wenhao Cui,Zejian Sun,Jiaxuan Xu,Xiaoyu Liu,Yunlu Kang,Lei Chen","doi":"10.1038/s41467-025-62421-6","DOIUrl":"https://doi.org/10.1038/s41467-025-62421-6","url":null,"abstract":"Glucose is a vital energy source essential for life and human health. Sodium-glucose cotransporter 2 (SGLT2) is a sodium-glucose symporter that utilizes the electrochemical gradient of sodium to reabsorb glucose from kidney filtrate back into circulation. SGLT2 plays a crucial role in maintaining blood glucose homeostasis and is an important drug target for type 2 diabetes. Despite its significance, the mechanisms by which SGLT2 recognizes and releases substrates during its transport cycle remain largely unknown. Here, we present structures of human SGLT2 in complex with a glucose analogue in the occluded conformation at 2.6 Å resolution, revealing a detailed hydrogen bonding network at the substrate binding site that governs substrate recognition. Additionally, structures of SGLT2 in both the substrate-bound inward-facing conformation and the substrate-free inward-facing conformations illustrate the structural changes that occur during substrate release into cytosol. Our structural analysis, combined with mutagenesis results, identifies specific polar interactions that are essential for maintaining the outer and inner gates in their closed conformations.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"38 1","pages":"7140"},"PeriodicalIF":16.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza A virus NS1 protein mimics oncogenic PI3K resulting in isoform specific cellular redistribution and activation.","authors":"Sadaf Aslam,María T Sánchez-Aparicio,Braden D Siempelkamp,Gillian L Dornan,Nikos Tsolakos,John E Burke,Benjamin G Hale,Adolfo García-Sastre,Juan Ayllon","doi":"10.1073/pnas.2423066122","DOIUrl":"https://doi.org/10.1073/pnas.2423066122","url":null,"abstract":"The nonstructural protein 1 (NS1) of influenza A virus performs a broad variety of proviral activities in the infected cell, primarily mediating evasion from the host innate immune response by being the main viral interferon antagonist. However, there are several interactions whose biological relevance remains obscure, such as the ability of NS1 to bind and activate class IA phosphoinositide 3-kinases (PI3Ks). PI3Ks are highly regulated lipid kinases that act as critical nodes in multiple cell signaling networks and are also important proto-oncogenes. This activation is mediated by NS1 binding specifically to the p85β subunit. To better understand the consequences of this interaction, we developed a bimolecular fluorescence complementation (BiFC) assay to selectively track the different PI3K heterodimers and, using this system, we found that NS1 induces an isoform-specific relocation and activation of the different PI3K heterodimers. We found that clinically relevant oncogenic mutations in both catalytic and regulatory subunits of PI3K could mimic the effect caused by NS1, and partially rescue the loss of viral fitness in a recombinant virus encoding a p85β-binding deficient NS1.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"10 1","pages":"e2423066122"},"PeriodicalIF":11.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eliminating hunger in a world serious about climate mitigation.","authors":"Jennifer A Burney","doi":"10.1073/pnas.2410202122","DOIUrl":"https://doi.org/10.1073/pnas.2410202122","url":null,"abstract":"What will it take to eliminate hunger in a world that is increasingly serious about climate change mitigation? For the past two decades, climate activism and mitigation efforts have largely focused on energy, industry, and transportation as the main contributors to anthropogenic warming. Although there is a long way to go to eliminate emissions from these sources, increasing international ambition means that attention is now turning to other hard-to-decarbonize sectors. Net zero food systems in particular pose unique challenges for humanity, given the moral dimensions of food security and the strong potential for vicious cycles: Globally hunger is back on the rise, the changing climate is already making food production for a growing population more difficult, and food shocks could lead to more land use change emissions that accelerate warming and feed back to negatively impact agricultural productivity and hunger. The dynamics of food production and consumption differ from other sectors and reveal several dimensions in which it will be critical to get policy right. Recent science suggests that two coordinated efforts will be needed to meet this challenge-a revamped focus on smallholder adaptation and productivity, and new \"safety valve\" institutions that sit at the intersection of food production and climate mitigation efforts and can operate at the relevant spatial and temporal scales to avoid negative tradeoffs in the quest to eliminate hunger and stabilize earth's climate.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"38 1","pages":"e2410202122"},"PeriodicalIF":11.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical valorization of H2S in natural gas to sulfate under mild conditions.","authors":"Chunyu Zhang,An-Zhen Li,Bo-Jun Yuan,Xiang Liu,Yuanbo Liu,Kejian Kong,Qiujin Shi,Yixuan Zhang,Yiqi Luo,Shengnan Li,Hua Zhou,Haohong Duan","doi":"10.1038/s41467-025-62445-y","DOIUrl":"https://doi.org/10.1038/s41467-025-62445-y","url":null,"abstract":"H2S capture and valorization from polluted natural gas offer environmental and resource recovery benefits, but current approaches produce moderate-value sulfur with intensive carbon footprint. Herein, we develop an electrochemical deep oxidation method that converts H2S from polluted natural gas into value-added K2SO4 using in-situ cathodically generated H2O2. We first validate this concept using commercial H2O2 and then in-situ generated H2O2 in H-cell, revealing the importance of high H2O2 concentration for deep H2S oxidation, especially sluggish S2O32--to-SO32- conversion. We then showcase its application potential in 4-cm2 and then 100-cm2 flow reactor with high interfacial H2O2 concentration and large current, with the latter achieving H2S removal (100,000 ppm to <15 ppm), >70% K2SO4 selectivity, and 100-h stable operation. Life-cycle assessment and techno-economic analysis confirm the strategy's sustainability advantages and economic viability. We finally extend this method to produce a 1.4 wt% H2SO4 solution by modifying the flow reactor with a solid-electrolyte type.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":"7175"},"PeriodicalIF":16.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Derailed degradation: LRRK2-dependent exocytosis in Parkinson's disease.","authors":"Shawn M Ferguson","doi":"10.1073/pnas.2515758122","DOIUrl":"https://doi.org/10.1073/pnas.2515758122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"29 1","pages":"e2515758122"},"PeriodicalIF":11.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chromatin and epigenetic regulation in malignant tumors: A comprehensive review.","authors":"Xiaoman Zhang,Dequan Liu,Xiaochi Chen,Tian Li,Guangzhen Wu","doi":"10.1111/nyas.70005","DOIUrl":"https://doi.org/10.1111/nyas.70005","url":null,"abstract":"Epigenetics and chromatin biology have been two distinct research fields for many years. There is a close relationship between epigenetics and chromatin biochemistry, and the dynamic changes of chromatin serve as an important basis for epigenetic regulation. The relationship between epigenetics and chromatin is reflected in the dynamic changes and structural adjustments of chromatin. In this article, we focus on previously underappreciated chromatin remodeling proteins. This review summarizes the biological significance of chromatin remodeling complexes in malignancies, including the physiological role of chromatin remodeling complexes in normal cells and the dysregulation of chromatin remodeling complexes in malignant tumors with genetic, epigenetic, and gene expression alterations. It is important to explore the impact of chromatin remodeling complexes on cancer therapy, as predictors of drug response, targets of drug response, and contributors to therapeutic resistance.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"30 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}