综合性期刊最新文献

{"title":"Ultrarapid decision-making in an avian brain","authors":"Philipp Schmidbauer, Andreas Nieder","doi":"10.1126/science.aed6459","DOIUrl":"https://doi.org/10.1126/science.aed6459","url":null,"abstract":"Perceptual decision-making is well studied in mammals, but its operation in other vertebrates remains unclear. We show that carrion crows ( <jats:italic toggle=\"yes\">Corvus corone</jats:italic> ) make deliberate decisions in a classic visual motion discrimination task with unprecedented speed, reporting choices in approximately 235 milliseconds on average, which is roughly twice as fast as has been observed in monkeys or humans and without sacrificing accuracy. Recordings from the pallial endbrain reveal that direction-selective neurons encode the upcoming choice as early as about 70 milliseconds after stimulus onset and about 170 milliseconds before the response, with ramping activity scaling with sensory evidence and converging at response onset. These findings highlight the extraordinary efficiency of avian decision-making circuitry, possibly shaped by evolutionary pressures for rapid visuomotor control.","PeriodicalId":21678,"journal":{"name":"Science","volume":"97 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermodynamic origin of the phonon Hall effect in a honeycomb antiferromagnet","authors":"Qingkai Meng, Xiaokang Li, Jie Liu, Lingxiao Zhao, Chao Dong, Zengwei Zhu, Liang Li, Kamran Behnia","doi":"10.1126/science.adt1992","DOIUrl":"https://doi.org/10.1126/science.adt1992","url":null,"abstract":"The underlying mechanism of the thermal Hall effect generated by phonons in a variety of insulators is yet to be identified. In this work, we report on a sizable thermal Hall conductivity in nickel phosphorus trisulfide (NiPS <jats:sub>3</jats:sub> ), a van der Waals stack of honeycomb layers with a zigzag antiferromagnetic order. The longitudinal (κ <jats:italic toggle=\"yes\"> <jats:sub>aa</jats:sub> </jats:italic> ) and the transverse (κ <jats:italic toggle=\"yes\"> <jats:sub>ab</jats:sub> </jats:italic> ) thermal conductivities peak at the same temperature, and the thermal Hall angle, at this peak, respects a previously identified bound. The amplitude of κ <jats:italic toggle=\"yes\"> <jats:sub>ab</jats:sub> </jats:italic> is extremely sensitive to the amplitude of magnetization along the <jats:italic toggle=\"yes\">b</jats:italic> axis but is not correlated with the phonon mean free path, which points to an intrinsic origin.","PeriodicalId":21678,"journal":{"name":"Science","volume":"13 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death","authors":"Shaoyuan Yang, Hyungjin Kim, Guanghong Liao, Na Ta, Ho-Chou Tu, Shriram Ramani, Chih-Yu Chen, Zih-Yu Li, Nobuhiro Tanno, James J. Hsieh, Emily H. Cheng","doi":"10.1126/science.aea2181","DOIUrl":"https://doi.org/10.1126/science.aea2181","url":null,"abstract":"The apoptotic regulators BAX and BAK, once activated, form homo-oligomers to trigger mitochondrial outer membrane permeabilization (MOMP), activating the apoptosome and caspases. Activation of BAX-BAK without apoptosome activation triggers sustained efflux of mitochondrial DNA (mtDNA) and caspase-independent cell death. However, the molecular basis of mtDNA efflux remains unclear. We purified a macromolecular complex comprising BAK, BAX, activator BH3-only molecules, voltage-dependent anion channels 1 and 2 (VDAC1 and VDAC2), and prohibitins that released mtDNA from mitoplasts. BAX-BAK activation resulted in VDAC closure, mitochondrial calcium influx, and mtDNA efflux. Loss of VDAC1, VDAC2, or prohibitins prevented BAX-BAK activation–induced mtDNA efflux and caspase-independent cell death without affecting MOMP or mitochondrial inner membrane herniation. These findings support differential regulation of cytochrome <jats:italic toggle=\"yes\">c</jats:italic> and mtDNA efflux by distinct BAX-BAK complexes.","PeriodicalId":21678,"journal":{"name":"Science","volume":"9 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoupled self-assembled monolayer and perovskite deposition for efficient flexible solar modules","authors":"Yeyong Wu, Xikun Zhang, Tiankai Zhang, Guiying Xu, Yunxiu Shen, Chengxin Guo, Qing Miao, Junyuan Ding, Yue Yin, Qinrong Cheng, Wen Liu, Xiaoxiao Wu, Kaiqiang Chen, Wenwen Kou, Zhiyun Cao, Haiyang Chen, Weijie Chen, Yujin Chen, Feng Gao, Yaowen Li, Yongfang Li","doi":"10.1126/science.aef9745","DOIUrl":"https://doi.org/10.1126/science.aef9745","url":null,"abstract":"The power conversion efficiency (PCE) and stability of flexible perovskite solar modules (PSMs) are less than those of their rigid devices because surface hydroxyls desorption on flexible substrates, which disrupts self-assembled monolayer (SAM) anchoring and perovskite crystallization. We developed a decoupled SAM-perovskite codeposition strategy that accelerates SAM anchoring by reducing the SAM-perovskite interaction and ameliorates perovskite crystallization. The certified PCE with phenethylammonium iodide as the passivation molecule was 20.2% on PSMs with device areas of 750 cm <jats:sup>2</jats:sup> . With 1,3-diaminopropane dihydroiodide as the passivator, the PCE of 22.0% for a device area of 14.55 cm <jats:sup>2</jats:sup> decreased by 8% after 1044 hours under maximum power point tracking at 85°C and 65% relative humidity. The devices pass all sequences of an international commercialization assessment standard for flexible portable PSMs.","PeriodicalId":21678,"journal":{"name":"Science","volume":"33 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late Holocene reexpansion of the Laurentide Ice Sheet","authors":"Nicolás E. Young, Gifford H. Miller, Martha Raynolds, Helga Bueltmann, Scott J. Lehman, Jonathan H. Raberg, Kylie Seward, Simon L. Pendleton, John T. Andrews, Patrick J. Webber, Joerg M. Schaefer","doi":"10.1126/science.aed3379","DOIUrl":"https://doi.org/10.1126/science.aed3379","url":null,"abstract":"During interglaciations, the Laurentide Ice Sheet (LIS), which is the largest of the Pleistocene ice sheets, retreats to Arctic Canada, where it achieves a minimum configuration. The reexpansion of the LIS following this minimum marks the start of the next glaciation. Here, we show that the last remaining remnant of the most recent LIS, Barnes Ice Cap (Baffin Island, Canada), achieved its minimum interglacial dimensions after ~3.6 thousand years ago, before reexpanding ~2000 years ago, marking the onset of the next glaciation. The new LIS reached maximum dimensions in ~1960 CE, after which anthropogenic summer warming resulted in a negative mass balance, ice margin recession, and the termination of the next glaciation. The demise of the next glaciation, despite the ongoing decline in summer insolation, illustrates the influence of anomalous greenhouse gas forcing on climate.","PeriodicalId":21678,"journal":{"name":"Science","volume":"1 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intron retention regulates STAT2 function and associates with immunotherapy response in lung cancer","authors":"Ryan P. Englander, Mattia Brugiolo, Maëva Devoucoux, Te-Chia Wu, Mitch Kostich, Nathan K. Leclair, Isha Walawalkar, Hyeon Gu Kang, SungHee Park, Florentina Marches, Mark E. Peeples, Phylip Chen, Jacques Banchereau, Peter Yu, Andrew Salner, Romain Banchereau, Karolina Palucka, Olga Anczuków","doi":"10.1126/science.aea7156","DOIUrl":"https://doi.org/10.1126/science.aea7156","url":null,"abstract":"Immunotherapy with checkpoint inhibitors has revolutionized cancer therapy and enabled considerable therapeutic advances for treating various diseases, including lung cancer. However, the molecular determinants of variable patient outcomes remain unclear. Using long-read RNA sequencing, we mapped the landscape of alternative RNA splicing in human primary lung adenocarcinomas. We identified more than 149,000 full-length messenger RNA (mRNA) isoforms, more than half of which were unannotated and many that occurred in immune-related genes, particularly within the type I interferon response pathway. We functionally characterized retained introns in the <jats:italic toggle=\"yes\">STAT2</jats:italic> gene that produced altered protein isoforms that regulated immune signaling and interferon responses and correlated with patient survival after anti–programmed death-ligand 1 (PD-L1) immunotherapy. These findings position alternative splicing as a regulator of tumor immune responses and reveal intron retention in <jats:italic toggle=\"yes\">STAT2</jats:italic> as an interferon regulatory axis that correlates with PD-L1 checkpoint inhibitor response.","PeriodicalId":21678,"journal":{"name":"Science","volume":"12 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electronic bound states in the continuum in a two-dimensional metal","authors":"Morgan Thinel, Xiong Huang, Daniel G. Chica, Simon Turkel, Sebastian E. Rossi, Christie S. Koay, Hong Li, Willa Mihalyi-Koch, Bipasa Samanta, Madisen Holbrook, Aravind Devarakonda, Luca M. Nashabeh, Alexandru B. Georgescu, Xavier Roy, Xiaoyang Zhu, Abhay N. Pasupathy, Raquel Queiroz","doi":"10.1126/science.adt9825","DOIUrl":"https://doi.org/10.1126/science.adt9825","url":null,"abstract":"Bound states in the continuum (BICs) are quantum states that remain localized despite lying within a continuum of extended, delocalized states. Whereas optical BICs have been realized in photonic systems, achieving electronic bound states embedded in a metallic background remains an ongoing challenge. In this study, we used scanning tunneling microscopy to identify two defect-induced electronic states that remain localized within the metallic continuum of Pd <jats:sub>5</jats:sub> AlI <jats:sub>2</jats:sub> , a two-dimensional van der Waals metal. Our calculations suggest that electron-hopping interference on the decorated checkerboard lattice of Pd <jats:sub>5</jats:sub> AlI <jats:sub>2</jats:sub> gives rise to a (quasi) flat band built from spatially localized eigenstates that are orthogonal to the dispersive continuum. Atomic defects within this frustrated lattice shift the associated flat-band localized states into the metallic continuum, forming robust, symmetry-protected BICs.","PeriodicalId":21678,"journal":{"name":"Science","volume":"2 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic functionality–enabled fast and selective transport in nanochannels","authors":"Hao Zhang, Yuan Kang, Fan Feng, Ting Hu, Rongming Xu, Hang Yu, Kaiqiang He, Zhe Yang, Zhuyuan Wang, Cher Hon Lau, Ze-Xian Low, Qinfen Gu, Jefferson Zhe Liu, Huanting Wang, Xiwang Zhang","doi":"10.1126/science.aed8319","DOIUrl":"https://doi.org/10.1126/science.aed8319","url":null,"abstract":"Nanochannels capable of fast and selective mass transport are central to applications in energy, resources, biomedicine, and the environment. However, extreme nanoscale confinement, often coupled with rigid channel environments, imposes substantial frictional and adhesive barriers, causing sluggish transport and constrained selectivity. We identified nanochannel dynamics as a key to addressing these challenges by harnessing the intrinsic mobility (e.g., self-rotation) of confined functionalities to enhance molecular transport. Through a combination of experiments and simulations, we demonstrated that such dynamics reshape transport by promoting kinetic energy transfer and enabling more efficient molecular relays, thereby improving separation performance beyond current benchmarks. Our findings highlight the role of nanochannel dynamics in regulating mass transport under confinement and provide a framework for designing advanced nanochannel systems.","PeriodicalId":21678,"journal":{"name":"Science","volume":"85 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wireless electrocatalytic closed-loop system for drug-free management of diabesity","authors":"Debasis Maity, Preetam Guha Ray, Peter Buchmann, Ghislaine Charpin-El Hamri, Martin Fussenegger","doi":"10.1126/science.ady8560","DOIUrl":"https://doi.org/10.1126/science.ady8560","url":null,"abstract":"Lifestyle-related type 2 diabetes and associated obesity (diabesity) affect &gt;2.5 billion people worldwide and impose nearly $3 trillion in annual health care costs. We developed an implantable, wirelessly powered electrocatalytic closed-loop health optimization (ECHO) device containing platinum-decorated gold nanoclusters embedded in graphite felt that enabled selective, electrically tunable oxidation of blood glucose to renally cleared gluconate. In type 2 diabetic mice, wireless, low-power activation (0.75 volts, 10 milliamperes) restored glucose homeostasis within 1 hour, shifted metabolism from glucose to lipid utilization, reduced body weight and triglycerides, and increased circulating free fatty acids and ketone bodies without detectable hypoglycemia or adverse physiological, inflammatory, or behavioral effects during 6 weeks of treatment. Coupling this ECHO device to a commercial continuous glucose monitoring system enabled autonomous, smartphone-controlled, drug-free closed-loop management of experimental diabesity.","PeriodicalId":21678,"journal":{"name":"Science","volume":"1 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential diagnosis with language models","authors":"Harsha Nori, Mayank Daswani, Christopher Kelly, Scott Lundberg, Marco Tulio Ribeiro, Marc Wilson, Xiaoxuan Liu, Viknesh Sounderajah, Jonathan M. Carlson, Matthew P. Lungren, Bay Gross, Peter Hames, Mustafa Suleyman, Dominic King, Eric Horvitz","doi":"10.1126/science.aeh7930","DOIUrl":"https://doi.org/10.1126/science.aeh7930","url":null,"abstract":"We explored the capabilities of frontier language models in sequential diagnosis, a diagnostic paradigm that captures the iterative nature of clinical reasoning. Given a brief clinical presentation, clinicians selectively acquired information to reach a diagnosis, enabling assessment of diagnostic accuracy and workup cost. We developed an interactive benchmark and an artificial intelligence (AI) system that simulates a panel of physicians, continually revising the differential diagnosis and selecting cost-effective tests. Using this benchmark, the system achieved 83.2% accuracy on <jats:italic toggle=\"yes\">New England Journal of Medicine</jats:italic> clinicopathological conference cases and 80.3% on MIMIC-IV-ED emergency department admissions, outperforming generalist physicians (36.1 and 46.8%, respectively). Although these findings were obtained in a controlled benchmark setting, they highlight the promise of language models for supporting more accurate, lower-cost diagnoses.","PeriodicalId":21678,"journal":{"name":"Science","volume":"12 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}