综合性期刊最新文献

{"title":"Inhibition of MBTPS1 enhances antitumor immunity and potentiates anti-PD-1 immunotherapy","authors":"Yi-Yu Wang, Jin-Fei Lin, Wen-Wei Wu, Zhe Fu, Fen Cao, Yan-Xing Chen, Hai-Yu Mo, Hui Sheng, Ze-Xian Liu, Zhao-Lei Zeng, Xin-Yuan Guan, Huai-Qiang Ju, Kun Liao, Rui-Hua Xu","doi":"10.1038/s41467-025-59193-4","DOIUrl":"https://doi.org/10.1038/s41467-025-59193-4","url":null,"abstract":"<p>Despite advances in cancer immunotherapy, colorectal cancer patients exhibit limited therapeutic responses. Therefore, the exploration of strategies combining immunotherapy with adjuvant approaches to enhance adaptive immune responses is in demand. Here, we perform a customized in vivo CRISPR-Cas9 screen to target genes encoding membrane and secreted proteins in CRC mouse models with different immune characteristics. We observe that loss of membrane-bound transcription factor site-1 protease (MBTPS1) in tumor cells enhances antitumor immunity and potentiates anti-PD-1 therapy. Mechanistic studies reveal that tumor cell-intrinsic MBTPS1 competes with USP13 for binding to STAT1, thereby disrupting the USP13-dependent deubiquitination-mediated STAT1 stabilization. The upregulated STAT1-transcribed chemokines including CXCL9, CXCL10, and CXCL11, promote CXCR3⁺CD8⁺ T cell infiltration. Notably, the regulatory role of MBTPS1 in antitumor immunity operates independently of its classic function in cleaving membrane-bound transcription factors. Collectively, our results provide a theoretical basis for MBTPS1 as a potential immunotherapy target.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"7 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantum simulation of spin-boson models with structured bath","authors":"Ke Sun, Mingyu Kang, Hanggai Nuomin, George Schwartz, David N. Beratan, Kenneth R. Brown, Jungsang Kim","doi":"10.1038/s41467-025-59296-y","DOIUrl":"https://doi.org/10.1038/s41467-025-59296-y","url":null,"abstract":"<p>The spin-boson model, involving spins interacting with a bath of quantum harmonic oscillators, is a widely used representation of open quantum systems that describe many dissipative processes in physical, chemical and biological systems. Trapped ions present an ideal platform for simulating the quantum dynamics of such models, by accessing both the high-quality internal qubit states and the motional modes of the ions for spins and bosons, respectively. We demonstrate a fully programmable method to simulate dissipative dynamics of spin-boson models using a chain of trapped ions, where the initial temperature and the spectral densities of the boson bath are engineered by controlling the state of the motional modes and their coupling with qubit states. Our method provides a versatile and precise experimental tool for studying open quantum systems.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"222 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epitope-optimized vaccine elicits enduring immunity against swine influenza A virus","authors":"Erika M. Petro-Turnquist, Adthakorn Madapong, Matthew Pekarek, David Steffen, Eric A. Weaver","doi":"10.1038/s41467-025-59182-7","DOIUrl":"https://doi.org/10.1038/s41467-025-59182-7","url":null,"abstract":"<p>Swine Influenza A Virus (IAV-S) poses a significant burden to both the pork industry and public health. Current vaccines against IAV-S are infrequently updated and induce strain-specific immunity. Computational platforms have recently emerged as a promising strategy to develop new-age vaccines. Here, we describe the Epigraph, a computationally derived and epitope optimized set of vaccine immunogens. When compared to wildtype immunogens (WT) and a commercial comparator (FluSure XP®), pigs immunized with Epigraph demonstrate significantly improved breadth and magnitude of antibody responses. Further, pigs immunized with Epigraph show more robust and a wider breadth of cross-reactive cell-mediated immune responses than pigs immunized with WT immunogens. In an experimental infection model, Epigraph immunized pigs demonstrate a significant reduction of clinical disease, lower shedding of infectious virus, reduction of lung lesions, and lower microscopic immunopathology compared to the other immunization groups. These data support the continued investigation of computationally designed and epitope optimized vaccine immunogens against influenza A virus.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"19 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why we need to measure people’s well-being — lessons from a global survey","authors":"Tyler J. VanderWeele, Byron R. Johnson","doi":"10.1038/d41586-025-01254-1","DOIUrl":"https://doi.org/10.1038/d41586-025-01254-1","url":null,"abstract":"Greater insights into what makes people happy, secure and hopeful will make for a better world.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"146 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to protect research data","authors":"","doi":"10.1038/d41586-025-01034-x","DOIUrl":"https://doi.org/10.1038/d41586-025-01034-x","url":null,"abstract":"Contingency plans are needed to shore up important information.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"73 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Romeo and the robots","authors":"","doi":"10.1038/d41586-025-01278-7","DOIUrl":"https://doi.org/10.1038/d41586-025-01278-7","url":null,"abstract":"A droid by any other name.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"1 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium-activated chloride channel TMEM16A opens via pi-helical transition in transmembrane segment 4","authors":"Andrei Y. Kostritskii, Yulia Kostritskaia, Natalia Dmitrieva, Tobias Stauber, Jan-Philipp Machtens","doi":"10.1073/pnas.2421900122","DOIUrl":"https://doi.org/10.1073/pnas.2421900122","url":null,"abstract":"TMEM16A is a Ca <jats:sup>2+</jats:sup> -activated Cl <jats:sup>−</jats:sup> channel that has crucial roles in various physiological and pathological processes. However, the structure of the open state of the channel and the mechanism of Ca <jats:sup>2+</jats:sup> -induced pore opening have remained elusive. Using extensive molecular dynamics simulations, protein structure prediction, and patch-clamp electrophysiology, we demonstrate that TMEM16A opens a hydrated Cl <jats:sup>−</jats:sup> -conductive pore via a pi-helical transition in transmembrane segment 4 (TM4). We also describe a coupling mechanism that links pi-helical transition and pore opening to the Ca <jats:sup>2+</jats:sup> -induced conformational changes in TMEM16A. Furthermore, we designed a pi-helix-stabilizing mutation (I551P) that facilitates TMEM16A activation, revealing atomistic details of the ion-conduction mechanism. Finally, AlphaFold2 structure predictions revealed the importance of the pi helix in TM4 to structure–function relations in TMEM16 and the related OSCA/TMEM63 family, further highlighting the relevance of dynamic pi helices for gating in various ion channels.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"43 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stiffness-gradient adhesive structure with mushroom-shaped morphology via electrically activated one-step growth","authors":"Duorui Wang, Tianci Liu, Hongmiao Tian, Jinyu Zhang, Qiguang He, Xiangming Li, Chunhui Wang, Xiaoliang Chen, Jinyou Shao","doi":"10.1073/pnas.2423039122","DOIUrl":"https://doi.org/10.1073/pnas.2423039122","url":null,"abstract":"Reptiles in nature have evolved excellent adhesion systems to adapt to complex natural environments, inspired by which high-performance bioinspired dry adhesives have been consistently created by precisely replicating the natural structures. Stiffness gradient, as a special feature evolved in reptilian adhesion systems, offers significant advantages in enhancing adhesion adaptation and stability. However, it remains a challenge to accurately replicate the geometrical morphology and soft-rigid composite properties of stiffness gradient structures, which limits the engineering applications of bioinspired adhesives. Here, a stiffness gradient adhesive structure with mushroom-shaped morphology via electrically activated one-step growth is proposed. Under the action of electric field, the liquid-phase polymer grows rheologically to realize the mushroom-shaped structural morphology, and the nanoparticles inside the polymer are aggregated toward the top by dielectrophoresis to realize the stiffness gradient distribution of rigid top and soft bottom. Due to the adaptation of the soft part to the interfacial contact and the effective inhibition of peeling by the rigid part, the proposed stiffness gradient structure improves the adhesion strength by 3 times in the parallel state and by 5 times in the nonparallel state compared to the conventional homogeneous structure. In addition, the application of adhesive structures in wall-climbing robots was demonstrated, opening an avenue for the development of dry adhesive-based devices and systems.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"8 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent self-correcting growth of uniform Bernal-stacked bi-/trilayer graphene","authors":"Wei Ma, Lai-Peng Ma, Xiao Kong, Han Yan, Zhibo Liu, Tiannan Han, Chao Zhu, Hui-Ming Cheng, Zheng Liu, Feng Ding, Wencai Ren","doi":"10.1073/pnas.2419968122","DOIUrl":"https://doi.org/10.1073/pnas.2419968122","url":null,"abstract":"State-of-the-art synthesis strategies of two-dimensional (2D) materials have been designed following the nucleation-dominant pattern for structure control. However, this classical methodology fails to achieve the precise layer- and stacking-resolved growth of wafer-scale few-layer 2D materials due to its intrinsically low energy resolution. Here, we present an intelligent self-correcting method for the high-resolution growth of uniform few-layer graphene. We demonstrate the layer-resolved growth of wafer-scale bilayer and trilayer graphene (BLG and TLG) with selective Bernal stacking through spontaneous correction of the single-layer graphene film with disordered multilayer graphene islands. Theoretical calculations reveal that the self-correcting growth is driven by the stepwise energy minimization of the closed system and kinetically activated by forming a low-barrier pathway for the carbon detachment-diffusion-attachment. Such uniform Bernal-stacked BLG and TLG films show high quality with distinct quantum Hall effect being observed. Our work opens an avenue for developing an intelligent methodology to realize the precise synthesis of diverse 2D materials.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"10 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preserve access to crucial climate data","authors":"","doi":"10.1038/d41586-025-01328-0","DOIUrl":"https://doi.org/10.1038/d41586-025-01328-0","url":null,"abstract":"Letter to the Editor","PeriodicalId":18787,"journal":{"name":"Nature","volume":"29 1","pages":"39-39"},"PeriodicalIF":64.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143884845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}