综合性期刊最新文献

{"title":"Transcriptional interferences ensure one olfactory receptor per ant neuron.","authors":"Bogdan Sieriebriennikov,Olena Kolumba,Aurore de Beaurepaire,Jennifer Wu,Valentina Fambri,Eva Bardol,Yuwei Zhong,Ildar Gainetdinov,Danny Reinberg,Hua Yan,Claude Desplan","doi":"10.1038/s41586-025-09664-x","DOIUrl":"https://doi.org/10.1038/s41586-025-09664-x","url":null,"abstract":"To ensure specificity, sensory neurons must select and express a single receptor from often vast gene families, adhering to the rule of 'one receptor per neuron'. For example, each olfactory sensory neuron in mammals expresses only one odorant receptor (Or) gene1,2. In Drosophila, which has about 60 Or genes, this selection is deterministic3. By contrast, mice face the challenge of choosing one Or gene from over 1,000 options4. They solve this through a complex system of stochastic choices5-9. Ants also possess many Or genes, most of which are organized into tandem arrays similar to those in mammals, but their regulatory mechanisms have evolved independently. Here we show that, in the ant Harpegnathos saltator, each olfactory sensory neuron activates a single promoter within an Or gene array, producing a mature capped and polyadenylated mRNA. While the promoters of downstream genes in the array are inactive, all downstream genes are nonetheless transcribed due to transcriptional readthrough from the active promoter, probably caused by inefficient RNA polymerase II termination. This readthrough appears to suppress downstream promoters through transcriptional interference, resulting in aberrant non-capped transcripts that are not translated, ensuring that only the active gene is expressed. Simultaneously, long antisense transcription originating from the chosen Or promoter covers upstream genes, presumably silencing them. Ants therefore appear to have evolved a unique transcriptional-interference-based mechanism to express a single OR protein from an array of Or genes with functionally similar promoters.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"23 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A global coral phylogeny reveals resilience and vulnerability through deep time.","authors":"Claudia Francesca Vaga,Andrea M Quattrini,Isabela Galvão de Lossio E Seiblitz,Danwei Huang,Zheng Bin Randolph Quek,Jarosław Stolarski,Stephen Douglas Cairns,Marcelo Visentini Kitahara","doi":"10.1038/s41586-025-09615-6","DOIUrl":"https://doi.org/10.1038/s41586-025-09615-6","url":null,"abstract":"Global climate change and its consequences for the symbiosis between corals and microalgae are impacting coral reefs worldwide-ecosystems that support more than one-quarter of marine species and sustain nearly one billion people1-3. Understanding how stony corals, the primary architects of both shallow and deep reef ecosystems, responded to past environmental challenges is key to predicting their future4. Here we describe a time-calibrated molecular phylogenetic analysis that includes hundreds of newly sequenced coral taxa, and sheds light on the deep-time evolution of scleractinian corals. We date the emergence of the most recent common ancestor of Scleractinia to about 460 million years ago and infer that it was probably a solitary, heterotrophic and free-living organism-or one that could reproduce through transverse division-thriving in both shallow and deep waters. Our analyses suggest that symbiosis with photosynthetic dinoflagellates was established around 300 million years ago and spurred coral diversification. However, only a few photosymbiotic lineages survived major environmental disruptions in the Mesozoic era. By contrast, solitary, heterotrophic corals with flexible depth and substrate preferences appear to have thrived in the deep sea despite these environmental disturbance events. Even though ongoing environmental changes are expected to severely affect shallow reefs5, our finding that stony corals have shown resilience throughout geological history offers hope for the persistence of some lineages in the face of climate and other environmental changes.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"1 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compounding future escalation of emissions- and irrigation-induced increases in humid-heat stress.","authors":"Yi Yao,Yusuke Satoh,Nicole van Maanen,Sabin Taranu,Jessica Keune,Steven J De Hertog,Seppe Lampe,David M Lawrence,William J Sacks,Yoshihide Wada,Agnès Ducharne,Benjamin I Cook,Sonia I Seneviratne,Laibao Liu,Jonathan R Buzan,Jonas Jägermeyr,Wim Thiery","doi":"10.1038/s41467-025-64375-1","DOIUrl":"https://doi.org/10.1038/s41467-025-64375-1","url":null,"abstract":"Irrigation has been investigated as an important historical climate forcing, but there is no study exploring its future climatic impacts considering possible changes in both extent and efficiency. Here, we address these issues via developing irrigation efficiency scenarios in line with the Shared Socioeconomic Pathways (SSPs), implementing these in the Community Earth System Model, and applying them to generate projections over the period 2015-2074. We project that annual irrigation water withdrawal decreases under SSP1-2.6 (from ~2100 to ~1700 km3 yr-1) but increases under SSP3-7.0 (to ~2400 km3 yr-1), with some new irrigation hot spots emerging, especially in Africa. Irrigation is projected to reduce the occurrence of dry-heat stress under both scenarios, but cannot reverse the warming trend due to greenhouse gas emission (e.g., increasing from ~90 to around 600 and 1200 hours yr-1 in intensely irrigated areas, under two scenarios). Moreover, moist-heat extreme event frequency increases more substantially (by ≥1600 hours yr-1 under SSP3-7.0 in tropical regions), and irrigation further amplifies the hours of exposure (for example, by ≥100 hours yr-1 in South Asia), thereby raising the risk of moist-heat-related illnesses and mortality for exposed communities. Our results underscore the importance of reducing greenhouse gas emissions, limiting irrigation expansion and improving irrigation efficiency to preserve water resources and decelerate escalating exposure to dry- and moist-heat stress.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"127 1","pages":"9326"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing sleep health equity through deep learning on large-scale nocturnal respiratory signals.","authors":"Zhongxu Zhuang,Biao Xue,Qiang An,Hui Chu,Yue Zhang,Rui Chen,Jing Xu,Ning Ding,Xiaochuan Cui,E Wang,Meilin Wang,Junyi Xin,Xuan Yang,Yan Xu,Yaxian Li,Chang-Hong Fu,Xiaohua Zhu,Mugen Peng,Hong Hong","doi":"10.1038/s41467-025-64340-y","DOIUrl":"https://doi.org/10.1038/s41467-025-64340-y","url":null,"abstract":"Sleep disorders affect billions globally, yet diagnostic access remains limited by healthcare resource constraints. Here, we develop a deep learning framework that analyzes respiratory signals for remote sleep health monitoring, trained on 15,785 nights of data across diverse populations. Our approach achieves robust performance in four-stage sleep classification (82.13% accuracy on internal validation; 79.62% on external validation) and apnea-hypopnea index estimation (intraclass correlation coefficients 0.90 and 0.94, respectively). Through transfer learning, we adapt the model to radar-derived respiratory signals, enabling contactless monitoring in home environments. The framework demonstrates consistent performance across demographic subgroups, supports real-time processing through self-supervised learning techniques, and integrates with a remote sleep health management platform for clinical deployment. This approach bridges critical gaps in sleep healthcare accessibility, supporting population-level screening and monitoring, paving the way for scalable sleep healthcare, and advancing sleep health equity.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"200 1","pages":"9334"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical simulations of hindlimb function in Alligator provide insights into postural shifts and body size evolution.","authors":"Masaya Iijima,Richard W Blob,John R Hutchinson","doi":"10.1126/sciadv.adx3811","DOIUrl":"https://doi.org/10.1126/sciadv.adx3811","url":null,"abstract":"The shift from sprawling to erect limb postures in archosaurs during the Triassic represents a major evolutionary transformation in vertebrates. One unresolved question regarding the limb posture transition is its association with body size evolution. If adopting more erect limb postures reduces mass-specific muscle forces and bone stresses, it would enable the evolution of larger body sizes. We tested this prediction using computational modeling and simulation of hindlimb muscle activations and femoral stresses across limb postures and body sizes in juvenile to adult American alligators and a scaled model of the extinct giant alligatoroid Deinosuchus riograndensis. We showed that larger alligators and D. riograndensis encounter challenges in generating sufficient muscle forces to support their bodies and maintain bone stresses, whereas adopting more erect hindlimb postures helps mitigate bone stresses among individuals of similar sizes. These results show how the shift from sprawling to erect limb posture relaxed biomechanical constraints, potentially facilitating the evolution of larger body sizes in terrestrial tetrapods.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"101 1","pages":"eadx3811"},"PeriodicalIF":13.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial reprogramming by HMGN1 underlies heart defects in trisomy 21.","authors":"Sanjeev S Ranade,Feiya Li,Sean Whalen,Angelo Pelonero,Lin Ye,Yu Huang,Abigail Brand,Tomohiro Nishino,Rahul Mital,Ryan M Boileau,Frances Koback,Arun Padmanabhan,Victoria Yu,Bastien Cimarosti,Diana Presas-Ramos,Alexander F Merriman,Langley Grace Wallace,Annie Nguyen,Nikolaos Poulis,Mauro W Costa,Casey A Gifford,Katherine S Pollard,Deepak Srivastava","doi":"10.1038/s41586-025-09593-9","DOIUrl":"https://doi.org/10.1038/s41586-025-09593-9","url":null,"abstract":"Congenital heart defects (CHDs) are the most common developmental abnormalities, affecting around 1% of live births1. Aneuploidy causes around 15% of CHDs, with trisomy 21 (also known as Down syndrome) being the most frequent form2. CHDs occur in around 50% of cases of Down syndrome, with an approximately 1,000-fold enrichment of atrioventricular canal (AVC) defects that disrupt the junction between the atria and ventricles3,4. The AVC contains unique myocardial cells that are essential for valvuloseptal development; however, the specific combination of dosage-sensitive genes on chromosome 21 that are responsible for Down syndrome-associated CHDs have remained unknown. Here, using human pluripotent stem cell and mouse models of Down syndrome, we identify HMGN1, a nucleosome-binding epigenetic regulator encoded on chromosome 21, as a key contributor to these defects. Single-cell transcriptomics showed that trisomy 21 shifts human AVC cardiomyocytes towards a ventricular cardiomyocyte state. A CRISPR-activation single-cell RNA droplet sequencing (CROP-seq) screen of chromosome 21 genes expressed during heart development revealed that HMGN1 upregulation mimics this shift, whereas deletion of one HMGN1 allele in trisomic cells restored normal gene expression. In a mouse model of trisomy 21, a similar transcriptional shift of AVC cardiomyocytes was restored by a reduction in Hmgn1 dosage, leading to rescue of valvuloseptal defects. These findings identify HMGN1 as a dosage-sensitive modulator of AVC development and cardiac septation in Down syndrome. This study offers a paradigm for dissecting aneuploidy-associated pathogenesis using isogenic systems to map causal genes in complex genetic syndromes.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"19 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surprise meteorite debris uncovered on Moon's far side.","authors":"Jenna Ahart","doi":"10.1038/d41586-025-03439-0","DOIUrl":"https://doi.org/10.1038/d41586-025-03439-0","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"58 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outrunning protein diffusion to the air-water interface in cryoEM.","authors":"Anastasiia Gusach,Kasim Sader,Christopher J Russo","doi":"10.1073/pnas.2516900122","DOIUrl":"https://doi.org/10.1073/pnas.2516900122","url":null,"abstract":"Here, we report a series of measurements indicating that it is physically possible to thin and vitrify a specimen for electron cryomicroscopy (cryoEM) faster than proteins diffuse to the air-water interface. We achieved this by spraying picoliter volume droplets at speeds of hundreds of meters per second into a thin layer of liquid ethane coating the surface of a precooled specimen support. The droplets simultaneously collapsed and froze in microseconds into the amorphous phase as they landed on the surface. The atomic structure of the proteins was preserved and tomographic reconstructions of the vitrified specimens indicated adhesion to the interfaces was eliminated. Improved control of the final thickness of the specimen and the orientation distribution of the particles are now the limiting factors. This demonstration provides a basis for the development of specimen preparation methods and instruments that eliminate the detrimental effects of the air-water interface in cryoEM.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"11 1","pages":"e2516900122"},"PeriodicalIF":11.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative potential of atmospheric particles in Europe and exposure scenarios.","authors":"Cécile Tassel,Jean-Luc Jaffrezo,Pamela Dominutti,Kaspar R Daellenbach,Sophie Darfeuil,Rhabira Elazzouzi,Paolo Laj,Anouk Marsal,Takoua Mhadhbi,Vy Ngoc Thuy Dinh,Céline Voiron,Stephan Houdier,Marc Durif,Mélodie Chatain,Florie Francony,Julie Cozic,Guillaume Salque Moreton,Meryll Le Quilleuc,Véronique Ghersi,Grégory Gille,Boualem Mesbah,Evdokia Stratigou,Manuela Zublena,Henri Diémoz,Andrés Alastuey,Barbara D'Anna,Nicolas Marchand,Sébastien Conil,Valérie Gros,Marloes F van Os,Imre Salma,Nikolaos Mihalopoulos,Griša Močnik,Katja Džepina,Katarzyna Styszko,Christoph Hüglin,Xavier Querol,André S H Prévôt,Olivier Favez,Valérie Siroux,Gaëlle Uzu","doi":"10.1038/s41586-025-09666-9","DOIUrl":"https://doi.org/10.1038/s41586-025-09666-9","url":null,"abstract":"Atmospheric particulate matter (PM), a public health concern worldwide, is at present regulated according to its mass concentration1. However, it is increasingly thought that mass concentration may not fully capture the physicochemical properties of PM linked to its health impact2. Consequently, it has been suggested to further investigate the adequacy of this metric as an unequivocal indicator of PM health effects3-5. The new European regulation on air quality introduced oxidative potential (OP) as a recommended parameter to be monitored at supersites1, to explore further deciphering information about PM reactivity and health impacts6,7. Here we use a database of almost 11,500 OP measurements from 43 locations across parts of Europe that were analysed with the two most commonly used OP assays8, OPAA and OPDTT, with a standardized protocol9,10. We find high spatial variability of OP across Europe, strongly influenced by site type, such as urban or rural. Accounting for OP alongside PM mass suggests that further improvements in urban air quality may require consideration, particularly near roads, where volumetric OP of PM10 exceeds background levels by a factor of 2.4 to 3.1, depending on the assay used. Analysis of mitigation strategies shows that traffic is a key source to target for effectively reducing OP in cities, whereas comprehensive reductions in PM from both traffic and biomass burning are required to also meet World Health Organization mass guidelines. Although the epidemiological evidence for OP health impacts is still evolving2,8, our findings may help inform the interpretation of future work.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"32 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction for Yu et al., Tetraphenylethene-based highly emissive metallacage as a component of theranostic supramolecular nanoparticles.","authors":"","doi":"10.1073/pnas.2527010122","DOIUrl":"https://doi.org/10.1073/pnas.2527010122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"101 1","pages":"e2527010122"},"PeriodicalIF":11.1,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}