{"title":"Advancing sleep health equity through deep learning on large-scale nocturnal respiratory signals.","authors":"Zhongxu Zhuang,Biao Xue,Qiang An,Hui Chu,Yue Zhang,Rui Chen,Jing Xu,Ning Ding,Xiaochuan Cui,E Wang,Meilin Wang,Junyi Xin,Xuan Yang,Yan Xu,Yaxian Li,Chang-Hong Fu,Xiaohua Zhu,Mugen Peng,Hong Hong","doi":"10.1038/s41467-025-64340-y","DOIUrl":null,"url":null,"abstract":"Sleep disorders affect billions globally, yet diagnostic access remains limited by healthcare resource constraints. Here, we develop a deep learning framework that analyzes respiratory signals for remote sleep health monitoring, trained on 15,785 nights of data across diverse populations. Our approach achieves robust performance in four-stage sleep classification (82.13% accuracy on internal validation; 79.62% on external validation) and apnea-hypopnea index estimation (intraclass correlation coefficients 0.90 and 0.94, respectively). Through transfer learning, we adapt the model to radar-derived respiratory signals, enabling contactless monitoring in home environments. The framework demonstrates consistent performance across demographic subgroups, supports real-time processing through self-supervised learning techniques, and integrates with a remote sleep health management platform for clinical deployment. This approach bridges critical gaps in sleep healthcare accessibility, supporting population-level screening and monitoring, paving the way for scalable sleep healthcare, and advancing sleep health equity.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"200 1","pages":"9334"},"PeriodicalIF":15.7000,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Communications","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1038/s41467-025-64340-y","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Sleep disorders affect billions globally, yet diagnostic access remains limited by healthcare resource constraints. Here, we develop a deep learning framework that analyzes respiratory signals for remote sleep health monitoring, trained on 15,785 nights of data across diverse populations. Our approach achieves robust performance in four-stage sleep classification (82.13% accuracy on internal validation; 79.62% on external validation) and apnea-hypopnea index estimation (intraclass correlation coefficients 0.90 and 0.94, respectively). Through transfer learning, we adapt the model to radar-derived respiratory signals, enabling contactless monitoring in home environments. The framework demonstrates consistent performance across demographic subgroups, supports real-time processing through self-supervised learning techniques, and integrates with a remote sleep health management platform for clinical deployment. This approach bridges critical gaps in sleep healthcare accessibility, supporting population-level screening and monitoring, paving the way for scalable sleep healthcare, and advancing sleep health equity.
期刊介绍:
Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.