Nature Communications最新文献

{"title":"Global divergence in plant and mycorrhizal fungal diversity hotspots","authors":"Laura G. van Galen, Justin D. Stewart, Clara Qin, Adriana Corrales, Bethan F. Manley, E. Toby Kiers, Thomas W. Crowther, Michael E. Van Nuland","doi":"10.1038/s41467-025-60106-8","DOIUrl":"https://doi.org/10.1038/s41467-025-60106-8","url":null,"abstract":"<p>Environmental protection strategies often rely on aboveground biodiversity indicators for prioritising conservation efforts. However, substantial biodiversity exists belowground, and it remains unclear whether aboveground diversity hotspots are indicative of high soil biodiversity. Using geospatial layers of vascular plant, arbuscular mycorrhizal fungi, and ectomycorrhizal fungi alpha diversity, we map plant–fungal diversity associations across different scales and evaluate evidence for potential correlation drivers. Plant–fungal diversity correlations are weak at the global scale but stronger at regional scales. Plant–arbuscular mycorrhizal fungal correlations are generally negative in forest biomes and positive in grassland biomes, whereas plant–ectomycorrhizal fungal correlations are mostly positive or neutral. We find evidence that symbiosis strength, environmental covariation, and legacy effects all influence correlation patterns. Only 8.8% of arbuscular mycorrhizal and 1.5% of ectomycorrhizal fungal diversity hotspots overlap with plant hotspots, indicating that prioritising conservation based solely on aboveground diversity may fail to capture diverse belowground regions.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"15 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An efficient and precise solution-vacuum hybrid batch fabrication of 2D/3D perovskite submodules","authors":"Yingping Fan, Zhixiao Qin, Lei Lu, Ni Zhang, Yugang Liang, Shaowei Wang, Wenji Zhan, Jiahao Guo, Haifei Wang, Yuetian Chen, Yanfeng Miao, Yixin Zhao","doi":"10.1038/s41467-025-62392-8","DOIUrl":"https://doi.org/10.1038/s41467-025-62392-8","url":null,"abstract":"<p>The quickly processable solution deposition and accurately controllable vacuum deposition are the two competing mainstream fabrication techniques for perovskite films. However, the former may inevitably leave pinholes on film surface and calls for further treatment, the latter exhibits a generally low processing rate. In this work, we develop a solution-vacuum hybrid batch fabrication to precisely deposit nanoscale two-dimensional (2D) capping layer via all-vacuum evaporation on a solution-deposited three-dimensional bulk film. The all-vacuum-deposited 2D perovskite capping layer can be finely controlled with desired composition and stoichiometry to passivate defects and heal the pristine pinholes. We demonstrate the high processing scalability of this solution-vacuum hybrid deposition with the fabrication of 30 cm × 30 cm pinhole-free perovskite submodules, which achieve a champion power conversion efficiency (PCE) up to 22.10% (certified PCE of 21.79%). Our discovery lays out a novel way for efficient and reproducible large-scale production of perovskite modules.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"21 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Black carbon emissions generally underestimated in the global south as revealed by globally distributed measurements","authors":"Yuxuan Ren, Christopher R. Oxford, Dandan Zhang, Xuan Liu, Haihui Zhu, Ann M. Dillner, Warren H. White, Rajan K. Chakrabarty, Sina Hasheminassab, David J. Diner, Emmie J. Le Roy, Joshin Kumar, Valerie Viteri, Keyao Song, Clement Akoshile, Omar Amador-Muñoz, Araya Asfaw, Rachel Ying-Wen Chang, Diana Francis, Paterne Gahungu, Rebecca M. Garland, Michel Grutter, Jhoon Kim, Kristy Langerman, Pei-Chen Lee, Puji Lestari, Olga L. Mayol-Bracero, Mogesh Naidoo, Narendra Nelli, Norm O’Neill, Sang Seo Park, Abdus Salam, Bighnaraj Sarangi, Yoav Schechner, Robyn Schofield, Sachchida N. Tripathi, Eli Windwer, Ming-Tsang Wu, Qiang Zhang, Yinon Rudich, Michael Brauer, Randall V. Martin","doi":"10.1038/s41467-025-62468-5","DOIUrl":"https://doi.org/10.1038/s41467-025-62468-5","url":null,"abstract":"<p>Characterizing black carbon (BC) on a fine scale globally is essential for understanding its climate and health impacts. However, sparse BC mass measurements in different parts of the world and coarse model resolution have inhibited evaluation of global BC emission inventories. Here, we apply globally distributed BC mass measurements from the Surface Particulate Matter Network (SPARTAN) and complementary measurement networks to evaluate contemporary BC emission inventories. We use a global chemical transport model (GEOS-Chem) in its high-performance configuration (GCHP) for high-resolution simulations to relate BC emissions to ambient concentrations for comparison with measurements. Here we find that simulations using the Community Emissions Data System (CEDS) emission inventory exhibit skill (r² = 0.73) in representing variability in SPARTAN measurements across primarily developed regions with low BC concentrations but exhibit pronounced discrepancy (r² = 0.00019) across high-BC regions in the Global South, underestimating BC by 38%. Alternative inventories (EDGAR, HTAP) yield similar results. These findings motivate renewed attention to the challenging task of characterizing BC emissions from low- and middle-income countries.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Enhancing energetic disorder in all-organic composite dielectrics for high-temperature capacitive energy storage","authors":"Tan Zeng, Li Meng, Qiao Li, Dongduan Liu, Qian Zhou, Jinliang He, Qi Li, Chao Yuan","doi":"10.1038/s41467-025-62435-0","DOIUrl":"https://doi.org/10.1038/s41467-025-62435-0","url":null,"abstract":"<p>Correction to: <i>Nature Communications</i> https://doi.org/10.1038/s41467-025-60741-1, published online 1 July 2025</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"14 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxygen vacancy-induced strengthening and toughening in (K,Na)NbO3-based piezoceramics revealed via nanoindentation","authors":"Zhidong Zhang, Bin Yang, Longyu Chen, Zaoli Zhang, Jinming Guo","doi":"10.1038/s41467-025-62424-3","DOIUrl":"https://doi.org/10.1038/s41467-025-62424-3","url":null,"abstract":"<p>Dislocations are emerging as a pivotal factor for tailoring ceramics’ functional and mechanical properties. The introduction of point defects, notably oxygen vacancies, is unavoidable during the conventional sintering process in polycrystalline ceramics. Understanding the interplay between dislocations and oxygen vacancies is necessary for its profound implications. This work implements an innovative approach to regulate the dislocation-based incipient plasticity and creep behavior in (K_0.5Na_0.5)NbO₃-based ceramics through oxygen vacancy engineering via CuO “hard” doping. Nanoindentation pop-in tests reveal that increasing oxygen vacancy concentrations significantly promotes the nucleation and activation of dislocations. Theoretical calculations based on density functional theory further corroborate that oxygen vacancies contribute to a decrease in Peierls stress and total misfit energy, facilitating dislocation nucleation and activation. Nanoindentation hardness and creep behavior demonstrate that oxygen vacancy impedes dislocation mobility due to solute strengthening and pinning effects. The effect of oxygen vacancies is elucidated through diverse mechanisms related to the interaction between dislocations and oxygen vacancies at different stages. This oxygen vacancy-induced strengthening and toughening strategy displays a significant potential to improve the mechanical properties of piezoelectric ceramics, while still maintaining high electrical performance.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"52 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase","authors":"Erin Skeens, Federica Maschietto, Ramu Manjula, Shanelle Shillingford, James Murphy, Elias J. Lolis, Victor S. Batista, Anton M. Bennett, George P. Lisi","doi":"10.1038/s41467-025-62150-w","DOIUrl":"https://doi.org/10.1038/s41467-025-62150-w","url":null,"abstract":"<p>Dual-specificity mitogen-activated protein kinase (MAPK) phosphatases (MKPs) directly dephosphorylate and inactivate the MAPKs. Although the catalytic mechanism of dephosphorylation of the MAPKs by the MKPs is established, a complete molecular picture of the regulatory interplay between the MAPKs and MKPs still remains to be fully explored. Here, we sought to define the molecular mechanism of MKP5 regulation through an allosteric site within its catalytic domain. We demonstrate using crystallographic and NMR spectroscopy approaches that residue Y435 is required to maintain the structural integrity of the allosteric pocket. Along with molecular dynamics simulations, these data provide insight into how changes in the allosteric pocket propagate conformational flexibility in the surrounding loops to reorganize catalytically crucial residues in the active site. Furthermore, Y435 is required for the interaction with p38 MAPK and JNK, thereby promoting dephosphorylation. Collectively, these results demonstrate critical roles for the allosteric site in coordinating both MKP5 catalysis and MAPK binding.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"10 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomas","authors":"April A. Apfelbaum, Eric Morin, Dominik Sturm, Georges Ayoub, Jeromy DiGiacomo, Sher Bahadur, Bhavyaa Chandarana, Phoebe C. Power, Margaret M. Cusick, Dana Novikov, Prem Prabhakar, Robert E. Jones, Jayne Vogelzang, Connor C. Bossi, Seth Malinowski, Lewis M. Woodward, Tania A. Jones, John Jeang, Sarah W. Lamson, Jared Collins, Kelly Y. Cai, Jacquelyn S. Jones, Sehee Oh, Hyesung Jeon, Jinhua Wang, Amy Cameron, Patrick Rechter, Angela De Leon, Karthikeyan Murugesan, Meagan Montesion, Lee A. Albacker, Shakti H. Ramkissoon, Cornelis M. van Tilburg, Emily C. Hardin, Philipp Sievers, Felix Sahm, Kee Kiat Yeo, Tom Rosenberg, Susan N. Chi, Karen D. Wright, Steven Hébert, Sydney Peck, Alberto Picca, Valérie Larouche, Samuele Renzi, Sara J. Buhrlage, Tejus A. Bale, Amy A. Smith, Mehdi Touat, Nada Jabado, Eric S. Fischer, Michael J. Eck, Lissa Baird, Olaf Witt, Claudia L. Kleinman, Quang-De Nguyen, Denise Sheer, Sanda Alexandrescu, David T. W. Jones, Keith L. Ligon, Pratiti Bandopadhayay","doi":"10.1038/s41467-025-61820-z","DOIUrl":"https://doi.org/10.1038/s41467-025-61820-z","url":null,"abstract":"<p>Oncogenic alterations in fibroblast growth factor receptor (FGFR)-family proteins occur across cancers, including pediatric gliomas. Our genomic analysis of 11,635 gliomas across ages finds that 5.3% of all gliomas harbor FGFR alterations, with an incidence of almost 9% in pediatric gliomas. Alterations in FGFR proteins are differentially enriched by age, tumor grade, and histology, with FGFR1 alterations associated with glioneuronal histologies. Leveraging isogenic systems, we confirm FGFR1 alterations to induce downstream Mitogen Activated Protein Kinase (MAPK) and mTOR signaling pathways, drive gliomagenesis, activate neuronal transcriptional programs and exhibit sensitivity to MAPK pathway and pan-FGFR inhibitors. Finally, we perform a retrospective analysis of clinical responses in children diagnosed with FGFR-altered gliomas and find that treatment with currently available inhibitors is largely associated with stability of disease. This study provides key insights into the biology of FGFR1-altered gliomas, therapeutic strategies to target them and associated challenges that still need to be overcome.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cytokine-based designer enzyme with an abiological multinuclear metal center exhibits intrinsic and extrinsic catalysis","authors":"Akiko Ueno, Fumiko Takida, Tomoki Kita, Takuro Ishii, Tomoki Himiyama, Takuya Mabuchi, Yasunori Okamoto","doi":"10.1038/s41467-025-61909-5","DOIUrl":"https://doi.org/10.1038/s41467-025-61909-5","url":null,"abstract":"<p>A designer enzyme consisting of an abiological molecule incorporated into a natural protein has been developed as an exceptionally chemoselective catalyst, highlighting that the internal space of proteins is highly beneficial for enhancing catalytic performance. However, other features of proteins have received less attention in designer enzymes, for e.g., their use as ligands to construct abiological (multinuclear) metal centers and their intrinsic functions that have often been traded off for a new function. Here, grafting a synthetic trinuclear zinc complex inside a human cytokine macrophage migration inhibitory factor (MIF) scaffold using solely amino-acid side chains leads to a designer multi-metalloenzyme with extrinsic and intrinsic functions. The crystal structure of the designer tri-zinc enzyme verifies the accuracy of our design process based on geometry optimizations and quantum-chemical calculations. The extrinsic catalytic performance of this designer enzyme is of the highest class and comparable to that of previously reported designer zinc hydrolases. Importantly, an intrinsic function of MIF, i.e., its tautomerase activity, is maintained in this designer tri-zinc enzyme. Considering that cytokines are originally expressed in response to in vivo events, this cytokine-based designer metalloenzyme holds promising potential as a synthetic biological tool for the self-adaptive regulation of life phenomena.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"733 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic C(sp3)–C(sp3) cross-coupling of carboxylic acids and alkyl halides using a nickel complex and carbon nitride","authors":"Miguel M. de Vries Ibáñez, Luis A. Cipriano, Valeria Lagostina, Andrea Olivati, Mario Chiesa, Annamaria Petrozza, Giovanni Di Liberto, Gianvito Vilé","doi":"10.1038/s41467-025-61639-8","DOIUrl":"https://doi.org/10.1038/s41467-025-61639-8","url":null,"abstract":"<p>Developing robust catalytic methods for constructing C(<i>sp</i>³)–C(<i>sp</i>³) bonds is critically important for synthesizing a diverse array of drug molecules. However, this type of reaction poses significant challenges from a chemical standpoint due to issues with regioselectivity, functional group tolerance and complex catalyst design. Current metallaphotoredox approaches do not provide a viable solution because they rely on expensive, toxic, and rare iridium-based photocatalysts, severely limiting their widespread application. In this study, we introduce carbon nitride nanosheets as an efficient and sustainable alternative to traditional photocatalysts. When combined with nickel, carbon nitride nanosheets facilitates the cross-coupling of alkyl halides and carboxylic acids. Our results demonstrate a broad substrate scope and highlight the recyclability of the photocatalyst. Density functional theory calculations provide molecular insights into the role of the catalytic system in facilitating photodecarboxylation and subsequent C–C bond formation. This work expands the potential of photoredox chemistry, and offers a novel method for efficient, industrially relevant light-to-chemical conversion processes.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Genetic fusions favor tumorigenesis through degron loss in oncogenes","authors":"Jing Liu, Collin Tokheim, Jonathan D. Lee, Wenjian Gan, Brian J. North, X. Shirley Liu, Pier Paolo Pandolfi, Wenyi Wei","doi":"10.1038/s41467-025-62490-7","DOIUrl":"https://doi.org/10.1038/s41467-025-62490-7","url":null,"abstract":"<p>Correction to: <i>Nature Communications</i> https://doi.org/10.1038/s41467-021-26871-y, published online 18 November 2021</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"26 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}