Nature Communications最新文献

Molecular architecture of Cryptococcus cell walls reveals species-specific chitosan-dependent remodeling 隐球菌细胞壁的分子结构揭示了物种特异性壳聚糖依赖性重塑

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-18 DOI: 10.1038/s41467-026-78940-9

Ankur Ankur,Rajendra Upadhya,Mahsa Doosti,Davis Ferreira,Sara E. Miller,Li Xie,Ivan Hung,Jennifer K. Lodge,Tuo Wang

{"title":"Molecular architecture of Cryptococcus cell walls reveals species-specific chitosan-dependent remodeling","authors":"Ankur Ankur,Rajendra Upadhya,Mahsa Doosti,Davis Ferreira,Sara E. Miller,Li Xie,Ivan Hung,Jennifer K. Lodge,Tuo Wang","doi":"10.1038/s41467-026-78940-9","DOIUrl":"https://doi.org/10.1038/s41467-026-78940-9","url":null,"abstract":"Abstract Cryptococcus neoformans and Cryptococcus gattii are fungal pathogens that cause life-threatening infections, including cryptococcal meningitis. A distinctive feature of the cryptococcal cell wall is the extensive deacetylation of chitin to chitosan, a modification that is essential for virulence but whose structural role in cell-wall organization remains poorly understood. Here, we analyze the cell walls of wild-type strains of both species and their avirulent chitosan-deficient mutants, which serve as vaccine candidates. Loss of chitosan disrupted cell morphology and altered cell-wall ultrastructure, with more pronounced defects in C. neoformans . Solid-state NMR reveals that aggregated α-(1→3)-glucans form the principal rigid domain of the cell wall in both species and are closely associated with chitin microfibrils, whereas surrounding β-glucans and mannoproteins constitute a more dynamic matrix. Chitosan modulates hydration and flexibility, and its loss increases chitin exposure and triggers species-specific remodeling of the polysaccharide network. In C. neoformans , chitosan depletion increased α-(1→3)-glucan content and reduced β-glucan levels, whereas C. gattii selectively lost one α-(1→3)-glucan subtype while maintaining β-glucan levels. Although capsule production remained intact, chitosan deficiency altered glucuronoxylomannan linkage patterns and mannoprotein composition. These findings reveal how chitosan organizes cryptococcal cell-wall architecture and highlight distinct structural adaptation strategies among pathogenic Cryptococcus species.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"2 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solvent heterogeneity regulates assembly pathways in supramolecular polymerization 溶剂非均质性调节超分子聚合的组装途径

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-18 DOI: 10.1038/s41467-026-78525-6

Goutam Ghosh,Jim Bachmann,Marvin Nyenhuis,Timo Krüger,Zulema Fernández,João Paulo Coelho,Antonia Albers,Max Köyer,Nikos Doltsinis,Gustavo Fernández

{"title":"Solvent heterogeneity regulates assembly pathways in supramolecular polymerization","authors":"Goutam Ghosh,Jim Bachmann,Marvin Nyenhuis,Timo Krüger,Zulema Fernández,João Paulo Coelho,Antonia Albers,Max Köyer,Nikos Doltsinis,Gustavo Fernández","doi":"10.1038/s41467-026-78525-6","DOIUrl":"https://doi.org/10.1038/s41467-026-78525-6","url":null,"abstract":"Abstract Supramolecular polymers are fundamental mimics of biological assemblies with diverse functions. However, predicting monomer solubility and controlling the colloidal stability of the resulting assemblies in solution remain major challenges. As a result, their preparation commonly relies on solvent mixtures, which can generate local heterogeneities during sample processing—an effect that remains poorly understood. Here, we demonstrate that solvent heterogeneity biases assembly pathways in supramolecular polymerization, with the extent of this effect modulated by monomer structure. Using an amphiphilic Pd(II) complex as a model system, we uncover a thermally accelerated transition from kinetically controlled discrete nanostructures to thermodynamically stable supramolecular polymers in water/1,4-dioxane mixtures. Combined experimental and theoretical analyses reveal that this transformation is mediated by microscopic liquid–liquid phase separation within the mixed solvent, creating 1,4-dioxane-enriched microdomains with increased local monomer concentration. Thermal annealing enhances molecular mobility and promotes the growth and coalescence of these microdomains, facilitating the transition to one-dimensional fibers. Extending the investigation to structurally related monomers further identifies the metal center and hydrogen-bonding motifs as key design elements governing this behavior. By linking molecular design and solvent heterogeneity to pathway complexity, our findings highlight how mixed solvents can be used to control supramolecular polymerization.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"11 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteroides–Escherichia interactions contribute to colonization resistance against Clostridioides difficile 拟杆菌-埃希氏菌相互作用有助于对艰难梭菌的定植抗性

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-18 DOI: 10.1038/s41467-026-78132-5

Achuthan Ambat,Naomi Iris van den Berg,Francisco Zorrilla,Shruti Menon,Abhijit Maji,Tanim Islam,Arianna Basile,Sudeep Ghimire,Lajos Kalmar,Kiran R. Patil,Joy Scaria

{"title":"Bacteroides–Escherichia interactions contribute to colonization resistance against Clostridioides difficile","authors":"Achuthan Ambat,Naomi Iris van den Berg,Francisco Zorrilla,Shruti Menon,Abhijit Maji,Tanim Islam,Arianna Basile,Sudeep Ghimire,Lajos Kalmar,Kiran R. Patil,Joy Scaria","doi":"10.1038/s41467-026-78132-5","DOIUrl":"https://doi.org/10.1038/s41467-026-78132-5","url":null,"abstract":"Abstract Commensal gut bacteria are key contributors to the resilience against pathogen invasion. This is exemplified by the success of faecal microbiota transplantation in treating recurrent Clostridioides difficile infection. Yet, characteristics of communities that can confer colonisation resistance and the underlying mechanisms remain largely unknown. Here we use a synthetic community of 14 commensal gut bacteria to uncover inter-species interactions and metabolic pathways underpinning the emergent resilience against C. difficile invasion. We challenged this synthetic community as well as faecal-matter-derived communities with antibiotic treatment and C. difficile in a continuous flow bioreactor. Using generalised Lotka-Volterra and genome-scale metabolic modelling, we identified interactions between Escherichia coli and Bacteroides/Phocaeicola sp. as key to the pathogen’s suppression. Metabolomics and targeted validation experiments revealed that fructan-derived fructooligosaccharides, vitamin B3 biosynthesis, and competition for Stickland metabolism precursors causally contribute to suppression across multiple C. difficile strains and donor backgrounds. Analysis of metagenomics data from patient cohorts and clinical trials attested the in vivo relevance of the identified metabolic pathways and the ratio between Bacteroides and Escherichia in successful colonisation resistance. The latter was found to be a stronger discriminator than commonly used alpha diversity metrics. Together, our study uncovers emergent microbial interactions in pathogen resistance with implications for rational design of bacteriotherapies.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"412 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enantioselective sp3-sp3 cross-coupling of oxygen-containing heterocycles with cyclopropanols 含氧杂环与环丙醇的对映选择性sp3-sp3交叉偶联

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-17 DOI: 10.1038/s41467-026-78834-w

Yang Ke,Huiyao Liu,Gaoyuan Yu,Yuanyuan Ping,Wangqing Kong

引用次数: 0

Adma and Ackr3a regulate cardiac lymphatic vessel formation and function during heart development and regeneration Adma和Ackr3a在心脏发育和再生过程中调节心脏淋巴管的形成和功能

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-17 DOI: 10.1038/s41467-026-78353-8

Xidi Feng,Hui-Yu Chen,Yuhan Sun,Fei Sun,Sean Yan,Subir Kapuria,Raquel Rodriguez,Laurent Gamba,J. Gage Crump,Young-Kwon Hong,Kenneth D. Poss,Ching-Ling Lien

引用次数: 0

Optical-handedness-driven enantioselective synthesis and programmable chirality encoding of covalent organic frameworks 光学手性驱动的共价有机骨架的对映选择合成和可编程手性编码

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-17 DOI: 10.1038/s41467-026-78524-7

Taewoong Kim,Jaewon Kim,Joohee Oh,Seungyoon Kang,Song Gyun Kim,Jee Hyeon Kim,Min Su Han,Young Yong Kim,Chanho Pak,Jeong-Eun Park,Hyunseob Lim

引用次数: 0

Breaking water-structure constraints by Hofmeister effects in interfacial polymerization for polyamide membranes 聚酰胺膜界面聚合中利用Hofmeister效应打破水结构约束

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-17 DOI: 10.1038/s41467-026-78649-9

Qingchen Tang,Hao Chen,Yu Chen,Hanyu Wu,Xingwang Meng,Wu Jin,Panjia Jiang,Yizhou Zhang,Xunda Feng

{"title":"Breaking water-structure constraints by Hofmeister effects in interfacial polymerization for polyamide membranes","authors":"Qingchen Tang,Hao Chen,Yu Chen,Hanyu Wu,Xingwang Meng,Wu Jin,Panjia Jiang,Yizhou Zhang,Xunda Feng","doi":"10.1038/s41467-026-78649-9","DOIUrl":"https://doi.org/10.1038/s41467-026-78649-9","url":null,"abstract":"Abstract Hydration critically governs the physicochemical behavior of solutes in both the aqueous bulk and interfacial environments. As typical chaotropic Hofmeister ions, weakly hydrated anions (WHAs) can reshape hydration structures and accumulate at water–hydrophobe interfaces. Notably, WHAs paradoxically suppress the solubility of certain small-molecule monomers in water while enhancing that of chemically analogous polymers. Here, we exploit WHA-mediated Hofmeister hydration control to regulate polyamide-forming interfacial polymerization (IP), using the piperazine (PIP) and trimesoyl chloride (TMC) nanofiltration system as the primary model. Introducing WHAs into the aqueous phase reduces the affinity of amine monomers for water and accelerates partitioning into the reaction front in the oil phase, remarkably reinforcing IP self-limitation. Simultaneously, interfacial WHA enrichment lowers interfacial tension and, together with accelerated amine delivery, potentially intensifies transport-driven interfacial instabilities. WHAs also lower interfacial water availability, attenuating acyl chloride hydrolysis. These synergistic effects yield hollow-ridged polyamide selective layers with reduced thickness and high crosslinking density, delivering enhanced water permeance and salt rejection. Crucially, module-scale fabrication of high-performance membranes demonstrates that WHA-mediated Hofmeister hydration control is directly compatible with established desalination pipelines.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"26 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coordinated control of both microtubule ends regulates mitotic spindle length 微管两端协调控制有丝分裂纺锤体长度

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-17 DOI: 10.1038/s41467-026-78426-8

Shane A. Fiorenza,Sheba Cheeran,Elena Doria,Iva M. Tolić,Patrick Meraldi,Nenad Pavin

{"title":"Coordinated control of both microtubule ends regulates mitotic spindle length","authors":"Shane A. Fiorenza,Sheba Cheeran,Elena Doria,Iva M. Tolić,Patrick Meraldi,Nenad Pavin","doi":"10.1038/s41467-026-78426-8","DOIUrl":"https://doi.org/10.1038/s41467-026-78426-8","url":null,"abstract":"Abstract The mitotic spindle is a biomechanical structure whose length must be precisely controlled to ensure faithful chromosome segregation. The treadmilling of microtubules towards spindle poles, termed poleward flux, is involved in spindle length control. However, poleward flux velocity has been shown to be both inversely and directly proportional to spindle length, a contradiction that remains unexplained by current mechanisms. Here we introduce a model which demonstrates that length-dependent regulation at both microtubule ends allows plus- and minus-end dynamics to synchronize with one another, enabling pathways of poleward-flux-based spindle length control which rectify previous results. Moreover, our model predicts that spindle length and poleward flux velocity can vary independently via simultaneous perturbations at both microtubule ends, which we validate with protein depletion experiments in human cells. Finally, we provide experimental evidence for length-dependent accumulation of proteins at microtubule minus-ends. Our results thus resolve a longstanding paradox and provide mechanistic insight into the reciprocal control of spindle length and poleward flux.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"33 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Permeability heterogeneity controls fluid migration and microseismicity evolution in The Geysers geothermal field, California 渗透率非均质性控制着加利福尼亚Geysers地热田流体运移和微震活动演化

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-17 DOI: 10.1038/s41467-026-78210-8

Lei Li,Xiaobao Zeng,Ian W. McBrearty,Xin Cui,Xing Tan,Shujuan Mao,Gregory C. Beroza,Jingqiang Tan,Jianxin Liu,Paul Segall,William L. Ellsworth

引用次数: 0

De novo design of lipopeptides with antimicrobial potency enabled by a chain-as-prompt deep learning framework 通过链-提示深度学习框架实现具有抗菌效力的脂肽的从头设计

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-17 DOI: 10.1038/s41467-026-78763-8

Fan Zhang,Xuchang Yu,Yuzhu Wu,Lei Li

引用次数: 0