Nature Communications最新文献

Mechanoelectric sensitivity reveals destructive quantum interference in single-molecule junctions 机械电灵敏度揭示单分子结中的破坏性量子干扰

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-21 DOI: 10.1038/s41467-024-53825-x

Sebastiaan van der Poel, Juan Hurtado-Gallego, Matthias Blaschke, Rubén López-Nebreda, Almudena Gallego, Marcel Mayor, Fabian Pauly, Herre S. J. van der Zant, Nicolás Agraït

{"title":"Mechanoelectric sensitivity reveals destructive quantum interference in single-molecule junctions","authors":"Sebastiaan van der Poel, Juan Hurtado-Gallego, Matthias Blaschke, Rubén López-Nebreda, Almudena Gallego, Marcel Mayor, Fabian Pauly, Herre S. J. van der Zant, Nicolás Agraït","doi":"10.1038/s41467-024-53825-x","DOIUrl":"https://doi.org/10.1038/s41467-024-53825-x","url":null,"abstract":"Quantum interference plays an important role in charge transport through single-molecule junctions, even at room temperature. Of special interest is the measurement of the destructive quantum interference dip itself. Such measurements are especially demanding when performed in a continuous mode of operation. Here, we use mechanical modulation experiments at ambient conditions to reconstruct the destructive quantum interference dip of conductance versus displacement. Simultaneous measurements of the Seebeck coefficient show a sinusoidal response across the dip without sign change. Calculations that include electrode distance and energy alignment variations explain both observations quantitatively, emphasizing the crucial role of thermal fluctuations for measurements under ambient conditions. Our results open the way for establishing a closer link between break-junction experiments and theory in explaining single-molecule transport phenomena, especially when describing sharp features in the transmission.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"18 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein 针对前融合 RSV F 蛋白保守区的强效广谱中和抗体

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-21 DOI: 10.1038/s41467-024-54384-x

Yongpeng Sun, Liqin Liu, Hongsheng Qiang, Hui Sun, Yichao Jiang, Luo Ren, Zemin Jiang, Siyu Lei, Li Chen, Yizhen Wang, Xue Lin, Guosong Wang, Yang Huang, Yuhao Fu, Yujin Shi, Xiuting Chen, Hai Yu, Shaowei Li, Wenxin Luo, Enmei Liu, Qingbing Zheng, Zizheng Zheng, Ningshao Xia

{"title":"A potent broad-spectrum neutralizing antibody targeting a conserved region of the prefusion RSV F protein","authors":"Yongpeng Sun, Liqin Liu, Hongsheng Qiang, Hui Sun, Yichao Jiang, Luo Ren, Zemin Jiang, Siyu Lei, Li Chen, Yizhen Wang, Xue Lin, Guosong Wang, Yang Huang, Yuhao Fu, Yujin Shi, Xiuting Chen, Hai Yu, Shaowei Li, Wenxin Luo, Enmei Liu, Qingbing Zheng, Zizheng Zheng, Ningshao Xia","doi":"10.1038/s41467-024-54384-x","DOIUrl":"https://doi.org/10.1038/s41467-024-54384-x","url":null,"abstract":"Respiratory syncytial virus (RSV) poses a significant public health challenge, especially among children. Although palivizumab and nirsevimab, neutralizing antibodies (nAbs) targeting the RSV F protein, have been used for prophylaxis, their limitations underscore the need for more effective alternatives. Herein, we present a potent and broad nAb, named 5B11, which exhibits nanogram level of unbiased neutralizing activities against both RSV-A and -B subgroups. Notably, 5B11 shows a ~20-fold increase in neutralizing efficacy compared to 1129 (the murine precursor of palivizumab) and approximately a 3-fold increase in neutralizing efficacy against B18537 in comparison to nirsevimab. Cryo-electron microscopy analysis reveals 5B11’s mechanism of action by targeting a highly conserved epitope within site V, offering a promising strategy with potentially lower risk of escape mutants. Antiviral testing in a female cotton rat model demonstrated that low-dose (1.5 mg/kg) administration of 5B11 achieved comparable prophylactic efficacy to that achieved by high-dose (15 mg/kg) of 1129. Furthermore, the humanized 5B11 showed a superior in vivo antiviral activity against B18537 infection compared to nirsevimab and palivizumab. Therefore, 5B11 is a promising RSV prophylactic candidate applicable to broad prevention of RSV infection.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"11 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryo-EM structures of apo-APC/C and APC/CCDH1:EMI1 complexes provide insights into APC/C regulation Apo-APC/C 和 APC/CCDH1:EMI1 复合物的低温电子显微镜结构揭示了 APC/C 的调控机制

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-21 DOI: 10.1038/s41467-024-54398-5

Anna Höfler, Jun Yu, Jing Yang, Ziguo Zhang, Leifu Chang, Stephen H. McLaughlin, Geoffrey W. Grime, Elspeth F. Garman, Andreas Boland, David Barford

{"title":"Cryo-EM structures of apo-APC/C and APC/CCDH1:EMI1 complexes provide insights into APC/C regulation","authors":"Anna Höfler, Jun Yu, Jing Yang, Ziguo Zhang, Leifu Chang, Stephen H. McLaughlin, Geoffrey W. Grime, Elspeth F. Garman, Andreas Boland, David Barford","doi":"10.1038/s41467-024-54398-5","DOIUrl":"https://doi.org/10.1038/s41467-024-54398-5","url":null,"abstract":"APC/C is a multi-subunit complex that functions as a master regulator of cell division. It controls progression through the cell cycle by timely marking mitotic cyclins and other cell cycle regulatory proteins for degradation. The APC/C itself is regulated by the sequential action of its coactivator subunits CDC20 and CDH1, post-translational modifications, and its inhibitory binding partners EMI1 and the mitotic checkpoint complex. In this study, we took advantage of developments in cryo-electron microscopy to determine the structures of human APC/CCDH1:EMI1 and apo-APC/C at 2.9 Å and 3.2 Å resolution, respectively, providing insights into the regulation of APC/C activity. The high-resolution maps allow the unambiguous assignment of an α-helix to the N-terminus of CDH1 (CDH1α1) in the APC/CCDH1:EMI1 ternary complex. We also identify a zinc-binding module in APC2 that confers structural stability to the complex, and we confirm the presence of zinc ions experimentally. Finally, due to the higher resolution and well defined density of these maps, we are able to build, aided by AlphaFold predictions, several intrinsically disordered regions in different APC/C subunits that likely play a role in proper APC/C assembly and regulation of its activity.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"252 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Width-dependent continuous growth of atomically thin quantum nanoribbons from nanoalloy seeds in chalcogen vapor 纳米合金种子在铬合金蒸气中按宽度连续生长出原子级超薄量子纳米带

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-21 DOI: 10.1038/s41467-024-54413-9

Xufan Li, Samuel Wyss, Emanuil Yanev, Qing-Jie Li, Shuang Wu, Yongwen Sun, Raymond R. Unocic, Joseph Stage, Matthew Strasbourg, Lucas M. Sassi, Yingxin Zhu, Ju Li, Yang Yang, James Hone, Nicholas Borys, P. James Schuck, Avetik R. Harutyunyan

{"title":"Width-dependent continuous growth of atomically thin quantum nanoribbons from nanoalloy seeds in chalcogen vapor","authors":"Xufan Li, Samuel Wyss, Emanuil Yanev, Qing-Jie Li, Shuang Wu, Yongwen Sun, Raymond R. Unocic, Joseph Stage, Matthew Strasbourg, Lucas M. Sassi, Yingxin Zhu, Ju Li, Yang Yang, James Hone, Nicholas Borys, P. James Schuck, Avetik R. Harutyunyan","doi":"10.1038/s41467-024-54413-9","DOIUrl":"https://doi.org/10.1038/s41467-024-54413-9","url":null,"abstract":"Nanoribbons (NRs) of atomic layer transition metal dichalcogenides (TMDs) can boost the rapidly emerging field of quantum materials owing to their width-dependent phases and electronic properties. However, the controllable downscaling of width by direct growth and the underlying mechanism remain elusive. Here, we demonstrate the vapor-liquid-solid growth of single crystal of single layer NRs of a series of TMDs (MeX2: Me = Mo, W; X = S, Se) under chalcogen vapor atmosphere, seeded by pre-deposited and respective transition metal-alloyed nanoparticles that also control the NR width. We find linear dependence of growth rate on supersaturation, known as a criterion for continues growth mechanism, which decreases with decreasing of NR width driven by the Gibbs-Thomson effect. The NRs show width-dependent photoluminescence and strain-induced quantum emission signatures with up to ≈ 90% purity of single photons. We propose the path and underlying mechanism for width-controllable growth of TMD NRs for applications in quantum optoelectronics.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"57 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox-switchable multicolor luminescent polymers for theragnosis of osteoarthritis 用于骨关节炎诊断的氧化还原可切换多色发光聚合物

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-21 DOI: 10.1038/s41467-024-54473-x

Chuan Peng, Yuling Zhu, Kaibo Zhang, Yiwei Wang, Yi Zheng, Yang Liu, Weili Fu, Hong Tan, Qiang Fu, Mingming Ding

引用次数: 0

Glycan-induced structural activation softens the human papillomavirus capsid for entry through reduction of intercapsomere flexibility 糖诱导的结构活化可通过降低囊膜间的柔韧性软化人类乳头瘤病毒的囊膜，使其便于进入人体

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-21 DOI: 10.1038/s41467-024-54373-0

Yuzhen Feng, Dominik van Bodegraven, Alan Kádek, Ignacio L. B. Munguira, Laura Soria-Martinez, Sarah Nentwich, Sreedeepa Saha, Florian Chardon, Daniel Kavan, Charlotte Uetrecht, Mario Schelhaas, Wouter H. Roos

{"title":"Glycan-induced structural activation softens the human papillomavirus capsid for entry through reduction of intercapsomere flexibility","authors":"Yuzhen Feng, Dominik van Bodegraven, Alan Kádek, Ignacio L. B. Munguira, Laura Soria-Martinez, Sarah Nentwich, Sreedeepa Saha, Florian Chardon, Daniel Kavan, Charlotte Uetrecht, Mario Schelhaas, Wouter H. Roos","doi":"10.1038/s41467-024-54373-0","DOIUrl":"https://doi.org/10.1038/s41467-024-54373-0","url":null,"abstract":"High-risk human papillomaviruses (HPVs) cause various cancers. While type-specific prophylactic vaccines are available, additional anti-viral strategies are highly desirable. Initial HPV cell entry involves receptor-switching induced by structural capsid modifications. These modifications are initiated by interactions with cellular heparan sulphates (HS), however, their molecular nature and functional consequences remain elusive. Combining virological assays with hydrogen/deuterium exchange mass spectrometry, and atomic force microscopy, we investigate the effect of capsid-HS binding and structural activation. We show how HS-induced structural activation requires a minimal HS-chain length and simultaneous engagement of several binding sites by a single HS molecule. This engagement introduces a pincer-like force that stabilizes the capsid in a conformation with extended capsomer linkers. It results in capsid enlargement and softening, thereby likely facilitating L1 proteolytic cleavage and subsequent L2-externalization, as needed for cell entry. Our data supports the further devising of prophylactic strategies against HPV infections.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"252 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterned electrical brain stimulation by a wireless network of implantable microdevices 通过植入式微型设备无线网络进行模式化脑电刺激

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-21 DOI: 10.1038/s41467-024-54542-1

A. H. Lee, J. Lee, V. Leung, L. Larson, A. Nurmikko

{"title":"Patterned electrical brain stimulation by a wireless network of implantable microdevices","authors":"A. H. Lee, J. Lee, V. Leung, L. Larson, A. Nurmikko","doi":"10.1038/s41467-024-54542-1","DOIUrl":"https://doi.org/10.1038/s41467-024-54542-1","url":null,"abstract":"Transmitting meaningful information into brain circuits by electronic means is a challenge facing brain-computer interfaces. A key goal is to find an approach to inject spatially structured local current stimuli across swaths of sensory areas of the cortex. Here, we introduce a wireless approach to multipoint patterned electrical microstimulation by a spatially distributed epicortically implanted network of silicon microchips to target specific areas of the cortex. Each sub-millimeter-sized microchip harvests energy from an external radio-frequency source and converts this into biphasic current injected focally into tissue by a pair of integrated microwires. The amplitude, period, and repetition rate of injected current from each chip are controlled across the implant network by implementing a pre-scheduled, collision-free bitmap wireless communication protocol featuring sub-millisecond latency. As a proof-of-concept technology demonstration, a network of 30 wireless stimulators was chronically implanted into motor and sensory areas of the cortex in a freely moving rat for three months. We explored the effects of patterned intracortical electrical stimulation on trained animal behavior at average RF powers well below regulatory safety limits.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"57 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagy modulates Arabidopsis male gametophyte fertility and controls actin organization 自噬调节拟南芥雄配子体的繁殖力并控制肌动蛋白组织

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-21 DOI: 10.1038/s41467-024-54468-8

He Yan, Zhen Lu, Xiaojuan Du, Zhengtao You, Mingkang Yang, Nianle Li, Xuequan Li, Zailue Ni, Hong Wu, Xiangfeng Wang, Lifeng Zhao, Hao Wang

{"title":"Autophagy modulates Arabidopsis male gametophyte fertility and controls actin organization","authors":"He Yan, Zhen Lu, Xiaojuan Du, Zhengtao You, Mingkang Yang, Nianle Li, Xuequan Li, Zailue Ni, Hong Wu, Xiangfeng Wang, Lifeng Zhao, Hao Wang","doi":"10.1038/s41467-024-54468-8","DOIUrl":"https://doi.org/10.1038/s41467-024-54468-8","url":null,"abstract":"Autophagy, a crucial mechanism for cellular degradation, is regulated by conserved autophagy-related (ATG) core proteins across species. Impairments in autophagy result in significant developmental and reproductive aberrations in mammals. However, autophagy is thought to be functionally dispensable in Arabidopsis thaliana since most of the ATG mutants lack severe growth and reproductive defects. Here, we challenge this perception by unveiling a role for autophagy in male gametophyte development and fertility in Arabidopsis. A detailed re-assessment of atg5 and atg7 mutants found that reduced autophagy activity in germinated pollen accompanied by partial aberrations in sperm cell biogenesis and pollen tube growth, leading to compromised seed formation. Furthermore, we revealed autophagy modulates the spatial organization of actin filaments via targeted degradation of actin depolymerization factors ADF7 and Profilin2 in pollen grains and tubes through a key receptor, Neighbor of BRCA1 (NBR1). Our findings advance the understanding of the evolutionary conservation and diversification of autophagy in modulating male fertility in plants contrasting to mammals.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personalised antimicrobial susceptibility testing with clinical prediction modelling informs appropriate antibiotic use 利用临床预测模型进行个性化抗菌药敏感性检测，为合理使用抗生素提供依据

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-21 DOI: 10.1038/s41467-024-54192-3

Alex Howard, David M. Hughes, Peter L. Green, Anoop Velluva, Alessandro Gerada, Simon Maskell, Iain E. Buchan, William Hope

{"title":"Personalised antimicrobial susceptibility testing with clinical prediction modelling informs appropriate antibiotic use","authors":"Alex Howard, David M. Hughes, Peter L. Green, Anoop Velluva, Alessandro Gerada, Simon Maskell, Iain E. Buchan, William Hope","doi":"10.1038/s41467-024-54192-3","DOIUrl":"https://doi.org/10.1038/s41467-024-54192-3","url":null,"abstract":"Antimicrobial susceptibility testing is a key weapon against antimicrobial resistance. Diagnostic microbiology laboratories use one-size-fits-all testing approaches that are often imprecise, inefficient, and inequitable. Here, we report a personalised approach that adapts laboratory testing for urinary tract infection to maximise the number of appropriate treatment options for each patient. We develop and assess susceptibility prediction models for 12 antibiotics on real-world healthcare data using an individual-level simulation study. When combined with decision thresholds that prioritise selection of World Health Organisation Access category antibiotics (those least likely to induce antimicrobial resistance), the personalised approach delivers more susceptible results (results that encourage prescription of that antibiotic) per specimen for Access category antibiotics than a standard testing approach, without compromising provision of susceptible results overall. Here, we show that personalised antimicrobial susceptibility testing could help tackle antimicrobial resistance by safely providing more Access category antibiotic treatment options to clinicians managing urinary tract infection.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"11 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calcium nanoparticles target and activate T cells to enhance anti-tumor function 钙纳米粒子靶向并激活 T 细胞，增强抗肿瘤功能

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-21 DOI: 10.1038/s41467-024-54402-y

Wei Yang, Zhizi Feng, Xinning Lai, Jianwen Li, Zhengwei Cao, Fangchao Jiang, Fanghui Chen, Shuyue Zhan, Feng Kong, Li Yang, Yong Teng, Wendy T. Watford, Gang Zhou, Jin Xie

{"title":"Calcium nanoparticles target and activate T cells to enhance anti-tumor function","authors":"Wei Yang, Zhizi Feng, Xinning Lai, Jianwen Li, Zhengwei Cao, Fangchao Jiang, Fanghui Chen, Shuyue Zhan, Feng Kong, Li Yang, Yong Teng, Wendy T. Watford, Gang Zhou, Jin Xie","doi":"10.1038/s41467-024-54402-y","DOIUrl":"https://doi.org/10.1038/s41467-024-54402-y","url":null,"abstract":"Calcium signaling plays a crucial role in the activation of T lymphocytes. However, modulating calcium levels to control T cell activation in vivo remains a challenge. In this study, we investigate T cell activation using 12-myristate 13-acetate (PMA)-encapsulated CaCO3 nanoparticles. We find that anti-PD-1 antibody-conjugated CaCO3 nanoparticles can be internalized by T cells via receptor-mediated endocytosis and then gradually release calcium. This results in an increase in cytosolic calcium, which triggers the activation of NFAT and NF-κB pathways, especially when the surface of the CaCO3 nanoparticles is loaded with PMA. Animal studies demonstrate that the PMA-loaded calcium nanoparticles enhance the activation and proliferation of cytotoxic T cells, leading to improved tumor suppression without additional toxicity. When tested in metastatic tumor models, T cells loaded with the calcium nanoparticles prior to adoptive cell transfer control tumor growth better, resulting in prolonged animal survival. Our approach offers an alternative T cell activation strategy to potentiate immunotherapy by targeting a fundamental signaling pathway.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"23 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0