Gong-Jun Ji, Michael D. Fox, Mae Morton-Dutton, Yingru Wang, Jinmei Sun, Panpan Hu, Xingui Chen, Yubao Jiang, Chunyan Zhu, Yanghua Tian, Zhiqiang Zhang, Haya Akkad, Janne Nordberg, Juho Joutsa, Cristina V. Torres Diaz, Sergiu Groppa, Gabriel Gonzalez-Escamilla, Maria de Toledo, Linda J. Dalic, John S. Archer, Richard Selway, Ioannis Stavropoulos, Antonio Valentin, Jimmy Yang, Faical Isbaine, Robert E. Gross, Sihyeong Park, Nicholas M. Gregg, Arthur Cukiert, Erik H. Middlebrooks, Nico U. F. Dosenbach, Joseph Turner, Aaron E. L. Warren, Melissa M. J. Chua, Alexander L. Cohen, Sara Larivière, Clemens Neudorfer, Andreas Horn, Rani A. Sarkis, Ellen J. Bubrick, Robert S. Fisher, John D. Rolston, Kai Wang, Frederic L. W. V. J. Schaper
{"title":"A generalized epilepsy network derived from brain abnormalities and deep brain stimulation","authors":"Gong-Jun Ji, Michael D. Fox, Mae Morton-Dutton, Yingru Wang, Jinmei Sun, Panpan Hu, Xingui Chen, Yubao Jiang, Chunyan Zhu, Yanghua Tian, Zhiqiang Zhang, Haya Akkad, Janne Nordberg, Juho Joutsa, Cristina V. Torres Diaz, Sergiu Groppa, Gabriel Gonzalez-Escamilla, Maria de Toledo, Linda J. Dalic, John S. Archer, Richard Selway, Ioannis Stavropoulos, Antonio Valentin, Jimmy Yang, Faical Isbaine, Robert E. Gross, Sihyeong Park, Nicholas M. Gregg, Arthur Cukiert, Erik H. Middlebrooks, Nico U. F. Dosenbach, Joseph Turner, Aaron E. L. Warren, Melissa M. J. Chua, Alexander L. Cohen, Sara Larivière, Clemens Neudorfer, Andreas Horn, Rani A. Sarkis, Ellen J. Bubrick, Robert S. Fisher, John D. Rolston, Kai Wang, Frederic L. W. V. J. Schaper","doi":"10.1038/s41467-025-57392-7","DOIUrl":"https://doi.org/10.1038/s41467-025-57392-7","url":null,"abstract":"<p>Idiopathic generalized epilepsy (IGE) is a brain network disease, but the location of this network and its relevance for treatment remain unclear. We combine the locations of brain abnormalities in IGE (131 coordinates from 21 studies) with the human connectome to identify an IGE network. We validate this network by showing alignment with structural brain abnormalities previously identified in IGE and brain areas activated by generalized epileptiform discharges in simultaneous electroencephalogram-functional magnetic resonance imaging. The topography of the IGE network aligns with brain networks involved in motor control and loss of consciousness consistent with generalized seizure semiology. To investigate therapeutic relevance, we analyze data from 21 patients with IGE treated with deep brain stimulation (DBS) for generalized seizures. Seizure frequency reduced a median 90% after DBS and stimulation sites intersect an IGE network peak in the centromedian nucleus of the thalamus. Together, this study helps unify prior findings in IGE and identify a brain network target that can be tested in clinical trials of brain stimulation to control generalized seizures.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"14 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A fungal pathogen suppresses host leaf senescence to increase infection","authors":"Yue Li, Xiangru Qu, Wenjuan Yang, Qin Wu, Xiaodong Wang, Qiantao Jiang, Jian Ma, Yazhou Zhang, Pengfei Qi, Guoyue Chen, Youliang Zheng, Xiaojie Wang, Yuming Wei, Qiang Xu","doi":"10.1038/s41467-025-58277-5","DOIUrl":"https://doi.org/10.1038/s41467-025-58277-5","url":null,"abstract":"<p>Phytopathogens such as <i>Puccinia striiformis</i> f. sp. <i>tritici</i> (<i>Pst</i>) induce pigment retention at pathogen infection sites. Although pigment retention is commonly observed in diverse pathosystems, its underlying physiological mechanism remains largely unclear. Herein, we identify and characterize a wheat leaf senescence gene, <i>TaSGR1</i>, which enhances resistance against <i>Pst</i> by promoting leaf senescence and H<sub>2</sub>O<sub>2</sub> accumulation while inhibiting photosynthesis. Knockout of <i>TaSGR1</i> (STAYGREEN) in wheat increases pigment retention and plant susceptibility. Pst_TTP1 (TaTrx-Targeting Protein 1), a secreted rust fungal effector critical for <i>Pst</i> virulence, binds to the plastidial thioredoxin TaTrx (Thioredoxin), preventing its translocation into chloroplasts. Within the chloroplasts, TaTrx catalyzes the transformation of TaSGR1 oligomers into monomers. These TaSGR1 monomers accumulate in the chloroplasts, accelerating leaf senescence, H<sub>2</sub>O<sub>2</sub> accumulation, and cell death. The inhibition of this oligomer-to-monomer transformation, caused by the failure of TaTrx to enter the chloroplast due to Pst_TTP1, impairs plant resistance against <i>Pst</i>. Overall, our study reveals the suppression of redox signaling cascade that catalyzes the transformation of TaSGR1 oligomers into monomers within chloroplasts and the inhibition of leaf chlorosis by rust effectors as key mechanisms underlying disease susceptibility.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"34 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microbiota-reprogrammed phosphatidylcholine inactivates cytotoxic CD8 T cells through UFMylation via exosomal SerpinB9 in multiple myeloma","authors":"Wei Yan, Xue Shi, Yun Zhao, Xiaoyu Liu, Xueming Jia, Le Gao, Jiahe Yuan, Aijun Liao, Hiroshi Yasui, Xiaobin Wang, Xiaotian Wang, Rui Zhang, Huihan Wang","doi":"10.1038/s41467-025-57966-5","DOIUrl":"https://doi.org/10.1038/s41467-025-57966-5","url":null,"abstract":"<p>Gut microbiome influences tumorigenesis and tumor progression through regulating the tumor microenvironment (TME) and modifying blood metabolites. However, the mechanisms by which gut microbiome and blood metabolites regulate the TME in multiple myeloma (MM) remain unclear. By employing16S rRNA gene sequencing coupled with metagenomics and ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry, we find that <i>Lachnospiraceae</i> are high and phosphatidylcholine (PC) are low in MM patients. We further show that <i>Lachnospiraceae</i> inhibits PC production from MM cells and enhances cytotoxic CD8 T cell function. Mechanistically, PC promotes Sb9 mRNA maturation in MM cells by LIN28A/B via lysophosphatidic acid, thus enhances exosamal Sb9 production. Exosamal Sb9 then reduces GZMB expression by suppressing tumor protein p53 (TP53) UFMylation via the competitive binding of TP53 with the ubiquitin-fold modifier conjugating enzyme 1 in CD8 T cells. We thus show that <i>Lachnospiraceae</i> and PC may be potential therapeutic targets for MM treatment.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"20 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Using machine learning to simultaneously quantify multiple cognitive components of episodic memory","authors":"Soroush Mirjalili, Audrey Duarte","doi":"10.1038/s41467-025-58265-9","DOIUrl":"https://doi.org/10.1038/s41467-025-58265-9","url":null,"abstract":"<p>Why do we remember some events but forget others? Previous studies attempting to decode successful vs. unsuccessful brain states to investigate this question have met with limited success, potentially due, in part, to assessing episodic memory as a unidimensional process, despite evidence that multiple domains contribute to episodic encoding. Using a machine learning algorithm known as “transfer learning”, we leveraged visual perception, sustained attention, and selective attention brain states to better predict episodic memory performance from trial-to-trial encoding electroencephalography (EEG) activity. We found that this multidimensional treatment of memory decoding improved prediction performance compared to traditional, unidimensional, methods, with each cognitive domain explaining unique variance in decoding of successful encoding-related neural activity. Importantly, this approach could be applied to cognitive domains outside of memory. Overall, this study provides critical insight into the underlying reasons why some events are remembered while others are not.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xiangmin Lv, Jiyuan Liu, Jinpeng Ruan, Peichao Chen, Chunbo He, Xingeng Zhao, Cong Huang, Li Chen, Hongbo Wang, Guohua Hua, Davie Shi, Siyi Yang, Madelyn L. Moness, Isabelle Montoute, Anjali Dhar, Xingcheng Chen, Raj Kumar, Hu Lu, Ruslan Sadreyev, Oladapo Yeku, Xu Wu, John S. Davis, Cheng Wang
{"title":"Targeting the disrupted Hippo signaling to prevent neoplastic renal epithelial cell immune evasion","authors":"Xiangmin Lv, Jiyuan Liu, Jinpeng Ruan, Peichao Chen, Chunbo He, Xingeng Zhao, Cong Huang, Li Chen, Hongbo Wang, Guohua Hua, Davie Shi, Siyi Yang, Madelyn L. Moness, Isabelle Montoute, Anjali Dhar, Xingcheng Chen, Raj Kumar, Hu Lu, Ruslan Sadreyev, Oladapo Yeku, Xu Wu, John S. Davis, Cheng Wang","doi":"10.1038/s41467-025-57697-7","DOIUrl":"https://doi.org/10.1038/s41467-025-57697-7","url":null,"abstract":"<p>Large-scale cancer genetic/genomic studies demonstrated that papillary renal cell carcinoma (pRCC) is featured with a frequent shallow deletion of the upstream tumor suppressors of the Hippo/YAP signaling pathway, suggesting that this signaling pathway may play a role in pRCC development. Here we develop a transgenic mouse model with a renal epithelial cell-specific hyperactivation of YAP1 and find that hyperactivation of YAP1 can induce dedifferentiation and transformation of renal tubular epithelial cells leading to the development of pRCC. We analyze at the single-cell resolution the cellular landscape alterations during cancer initiation and progression. Our data indicate that the hyperactivated YAP1, via manipulating multiple signaling pathways, induces epithelial cell transformation, MDSC (Myeloid-derived suppressor cells) accumulation, and pRCC development. Interestingly, we find that depletion of MDSC blocks YAP1-induced kidney overgrowth and tumorigenesis. Inhibiting YAP1 activity with MGH-CP1, a recently developed TEAD inhibitor, impedes MDSC accumulation and suppresses tumor development. Our results identify the disrupted Hippo/YAP signaling as a major contributor to pRCC and suggest that targeting the disrupted Hippo pathway represents a plausible strategy to prevent and treat pRCC.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"37 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Benchmarking metagenomic binning tools on real datasets across sequencing platforms and binning modes","authors":"Haitao Han, Ziye Wang, Shanfeng Zhu","doi":"10.1038/s41467-025-57957-6","DOIUrl":"https://doi.org/10.1038/s41467-025-57957-6","url":null,"abstract":"<p>Metagenomic binning is a culture-free approach that facilitates the recovery of metagenome-assembled genomes by grouping genomic fragments. However, there remains a lack of a comprehensive benchmark to evaluate the performance of metagenomic binning tools across various combinations of data types and binning modes. In this study, we benchmark 13 metagenomic binning tools using short-read, long-read, and hybrid data under co-assembly, single-sample, and multi-sample binning, respectively. The benchmark results demonstrate that multi-sample binning exhibits optimal performance across short-read, long-read, and hybrid data. Moreover, multi-sample binning outperforms other binning modes in identifying potential antibiotic resistance gene hosts and near-complete strains containing potential biosynthetic gene clusters across diverse data types. This study also recommends three efficient binners across all data-binning combinations, as well as high-performance binners for each combination.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"7 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A protease-cleavable liposome for co-delivery of anti-PD-L1 and doxorubicin for colon cancer therapy in mice","authors":"Yixuan Liu, Ying Xie, Yuling Chen, Jialun Duan, Chunjie Bao, Jinling Wang, Hexuan Feng, Mengjie Wang, Yuxin Ren, Peishan Li, Qian Luo, Jiarui Xu, Min Jiang, Yanchen Men, Yang Wu, Jianwei Li, Guiling Wang, Wanliang Lu","doi":"10.1038/s41467-025-57965-6","DOIUrl":"https://doi.org/10.1038/s41467-025-57965-6","url":null,"abstract":"<p>Immune checkpoint blockade therapy using programmed cell death 1 (PD1) or programmed death ligand 1 (PD-L1) has made significant progress in the treatment of advanced cancers, with some patients achieving long-term remission without clinical recurrence. However, only a minority of colon cancer patients respond to the therapy. Here, we report a protease-cleavable anti-PD-L1 antibody liposome, eLipo anti-PD-L1, for enhancing colon cancer therapy. In vivo, eLipo anti-PD-L1 is cleaved by legumain at colon cancer site into pegylated anti-PD-L1 and cancer-homing doxorubicin liposome. Functional assessments show cancer-targeting, legumain-responding, tumor-penetrating, and immune-activating effects, as well as efficacy in treating colon cancer-bearing mice in vivo. Further mechanistic analysis implicates genes related to T cell differentiation and T cell receptor signaling as potential molecular mediators. Lastly, human colorectal cancer tissue evaluations verify expressions of PD-L1 and legumain, hinting a potential translatability. Our study thus suggests that eLipo anti-PD-L1 may be a feasible vector for co-delivery of immunochemotherapy for colon cancer.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"57 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yun Gao, Dan Wu, Jie Song, Xueyi Zhang, Bangbang Hou, Hengfa Liu, Junqi Liao, Liang Zhou
{"title":"A wearable obstacle avoidance device for visually impaired individuals with cross-modal learning","authors":"Yun Gao, Dan Wu, Jie Song, Xueyi Zhang, Bangbang Hou, Hengfa Liu, Junqi Liao, Liang Zhou","doi":"10.1038/s41467-025-58085-x","DOIUrl":"https://doi.org/10.1038/s41467-025-58085-x","url":null,"abstract":"<p>It is challenging for wearable obstacle avoidance devices to simultaneously meet practical demands of high reliability, rapid response, long-lasting duration, and usable design. Here we report a wearable obstacle avoidance device, comprising a set of self-developed glasses (weighing ~400 grams, including an ~80 grams battery) and a common smartphone. Specifically, the glasses collect the multi-modal data for comprehensive environmental perception, including video and depth modalities, and implement a depth-aided video compression module. This module not only adaptively compresses video data to reduce transmission delay to the smartphone, but also operates on a customized FPGA board featuring a multi float-point vector unit streaming processing architecture, thereby facilitating responsive and energy-efficient obstacle detection. Additionally, we design a cross-modal obstacle detection module on the smartphone, which ensures reliable detection and provides user-friendly auditory and tactile alerts by utilizing cross-modal learning based on modal correlations. Multiple indoor and outdoor experimental results demonstrate 100% collision avoidance rates, delay of less than 320 ms, and duration of approximately 11 hours.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"28 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surpassing stoichiometric limitation for supra-multi-molar adsorption and separation of acid gases","authors":"Guanqing Zhang, Fengqing Liu, Shouchao Zhong, Fujian Liu, Qiliang Zhu, Yu Tang, Jingyi Tan, Anmin Zheng, Lilong Jiang, Feng-Shou Xiao","doi":"10.1038/s41467-025-58148-z","DOIUrl":"https://doi.org/10.1038/s41467-025-58148-z","url":null,"abstract":"<p>Capture of acid gases holds crucial importance for addressing air pollution and climate change, where achieving a molar ratio for adsorption and separation of acid gases on an active site higher than 1.0 remains challenging. Herein, we demonstrate that three nitrogen-bonded one Zn sites within a single-crystalline-like porous carbon (Zn-N<sub>3</sub>@SC-PC) derived from controlled carbonization of ZIF-8-C ≡ N with KCl, exhibit supra-multi-molar adsorption for CO<sub>2</sub>, COS, and H<sub>2</sub>S, even to 1:6 ratio for SO<sub>2</sub> on the Zn-N<sub>3</sub>. This exceptional performance is attributed to the protruded structure in the Zn-N<sub>3</sub>@SC-PC for more coordination between Zn vacant orbital and acid gases evidenced by DFT calculation and in situ EXAFS. The high capacity for capturing acid gases on this adsorbent is crucial for future in carbon neutrality and environment protection.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"9 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-viral generation of transgenic non-human primates via the piggyBac transposon system","authors":"Masataka Nakaya, Chizuru Iwatani, Setsuko Tsukiyama-Fujii, Ai Mieda, Shoko Tarumoto, Taro Tsujimura, Takuya Yamamoto, Takafumi Ichikawa, Tomonori Nakamura, Ichiro Terakado, Ikuo Kawamoto, Takahiro Nakagawa, Iori Itagaki, Mitinori Saitou, Hideaki Tsuchiya, Tomoyuki Tsukiyama","doi":"10.1038/s41467-025-57365-w","DOIUrl":"https://doi.org/10.1038/s41467-025-57365-w","url":null,"abstract":"<p>Non-human primates, such as cynomolgus monkeys, are invaluable experimental models for understanding human biology and disease. Their close genetic relationship to humans makes them essential for studying fundamental human developmental processes and disease progression. Although lentiviral methods for generating transgenic monkeys exist, several inherent technical difficulties limit their utility. To solve this problem, here we establish a non-viral method for generating transgenic cynomolgus monkeys using the piggyBac transposon system. After optimizing our protocol in mice, we show that the co-injection of piggyBac components with sperm into metaphase II-stage oocytes successfully generates transgenic monkeys expressing transgenes throughout their whole bodies. Transgene expression is observed in all examined tissue types, including germ cells, although the levels of expression vary. Insertion analysis further confirms the successful integration of the transgene. We propose that our method will be a practical non-viral protocol for generating transgenic non-human primates.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"3 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143677546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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