Nature Communications最新文献_第10页

The conformations of protein chains at the interface of biomolecular condensates 生物分子凝聚体界面上的蛋白质链构象

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-19 DOI: 10.1038/s41467-024-53575-w

D. Janka Bauer, Arash Nikoubashman

引用次数: 0

Ecosystem transplant from a healthy reef boosts coral health at a degraded reef 从健康珊瑚礁移植生态系统可促进退化珊瑚礁的珊瑚健康

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-19 DOI: 10.1038/s41467-024-54149-6

Natalie Levy, Joseane A. Marques, Noa Simon-Blecher, David G. Bourne, Tirza Doniger, Jennifer I. C. Benichou, Jin Yan Lim, Ezri Tarazi, Oren Levy

{"title":"Ecosystem transplant from a healthy reef boosts coral health at a degraded reef","authors":"Natalie Levy, Joseane A. Marques, Noa Simon-Blecher, David G. Bourne, Tirza Doniger, Jennifer I. C. Benichou, Jin Yan Lim, Ezri Tarazi, Oren Levy","doi":"10.1038/s41467-024-54149-6","DOIUrl":"https://doi.org/10.1038/s41467-024-54149-6","url":null,"abstract":"Organismal communities associated with coral reefs, particularly invertebrates and microbes, play crucial roles in ecosystem maintenance and coral health. Here, we characterized the organismal composition of a healthy, non-urbanized reef (Site A) and a degraded, urbanized reef (Site B) in the Gulf of Eilat/Aqaba, Red Sea to assess its impact on coral health and physiology. Biomimetically designed terracotta tiles were conditioned for 6 months at both sites, then reciprocally transplanted, and scleractinian coral species, Acropora eurystoma and Stylophora pistillata, were attached for an additional 6 months. After 12 months, tiles from Site A transplanted to Site B exhibited greater invertebrate richness and diversity than Site B’s original tiles (via Cytochrome c. Oxidase subunit I metabarcoding). Key bacteria from the healthy reef were more prevalent on Site A tiles and on the tiles transplanted to Site B (via 16S rRNA gene sequencing). Corals originally from Site B attached to transplanted healthy tiles (Site A) showed higher photochemical capacity, increased endosymbionts, and reduced physiological stress, measured by total antioxidant capacity and an integrated biomarker response. Our findings demonstrate the successful transfer of organismal communities between reefs, highlighting the potential benefits of healthy reef-associated invertebrates and microbes on coral physiology and their implications for reef restoration strategies.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"22 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142672900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design towards recyclable micron-sized Na₂S cathode with self-refinement mechanism. 设计具有自精炼机制的可回收微米级 Na2S 阴极。

IF 14.7 1区综合性期刊

Nature Communications Pub Date : 2024-11-19 DOI: 10.1038/s41467-024-54316-9

Suwan Lu, Yang Liu, Jingjing Xu, Shixiao Weng, Jiangyan Xue, Lingwang Liu, Zhicheng Wang, Can Qian, Guochao Sun, Yiwen Gao, Qingyu Dong, Hong Li, Xiaodong Wu

{"title":"Design towards recyclable micron-sized Na2S cathode with self-refinement mechanism.","authors":"Suwan Lu, Yang Liu, Jingjing Xu, Shixiao Weng, Jiangyan Xue, Lingwang Liu, Zhicheng Wang, Can Qian, Guochao Sun, Yiwen Gao, Qingyu Dong, Hong Li, Xiaodong Wu","doi":"10.1038/s41467-024-54316-9","DOIUrl":"10.1038/s41467-024-54316-9","url":null,"abstract":"Sodium sulfide (Na2S) as an initial cathode material in room-temperature sodium-sulfur batteries is conducive to get rid of the dependence on Na-metal anode. However, the micron-sized Na2S that accords with the practical requirements is obstructed due to poor kinetics and severe shuttle effect. Herein, a subtle strategy is proposed via regulating Na2S redeposition behaviours. By the synergistic effect from both conductive structure and cuprous sulfide (Cu2S) catalysis, the micron-sized Na2S particles are broken down and redeposited to nano-size during the initial cycle which can be fully utilized in subsequent cycles. Consequently, the Na2S/CPVP@Cu2S||Na cell delivers excellent cyclability (670 mAh gS-1 after 500 cycles) with a remarkable average Coulombic efficiency over 99.7% and rate capability (480 mAh gS-1 at 4 A gS-1). Besides, the Na-free anodes are used to prove the application prospects. This work provides an innovative idea for utilizing micron-sized Na2S and offers insights into its conversion pathway.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"15 1","pages":"9995"},"PeriodicalIF":14.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Halogencarbene-free Ciamician-Dennstedt single-atom skeletal editing. 无卤代碳化物的 Ciamician-Dennstedt 单原子骨骼编辑。

IF 14.7 1区综合性期刊

Nature Communications Pub Date : 2024-11-19 DOI: 10.1038/s41467-024-54379-8

Shaopeng Liu, Yong Yang, Qingmin Song, Zhaohong Liu, Paramasivam Sivaguru, Yifan Zhang, Graham de Ruiter, Edward A Anderson, Xihe Bi

引用次数: 0

A self-healing plastic ceramic electrolyte by an aprotic dynamic polymer network for lithium metal batteries 用于锂金属电池的钝化动态聚合物网络自修复塑料陶瓷电解质

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-19 DOI: 10.1038/s41467-024-53869-z

Yubin He, Chunyang Wang, Rui Zhang, Peichao Zou, Zhouyi Chen, Seong-Min Bak, Stephen E. Trask, Yonghua Du, Ruoqian Lin, Enyuan Hu, Huolin L. Xin

{"title":"A self-healing plastic ceramic electrolyte by an aprotic dynamic polymer network for lithium metal batteries","authors":"Yubin He, Chunyang Wang, Rui Zhang, Peichao Zou, Zhouyi Chen, Seong-Min Bak, Stephen E. Trask, Yonghua Du, Ruoqian Lin, Enyuan Hu, Huolin L. Xin","doi":"10.1038/s41467-024-53869-z","DOIUrl":"https://doi.org/10.1038/s41467-024-53869-z","url":null,"abstract":"Oxide ceramic electrolytes (OCEs) have great potential for solid-state lithium metal (Li0) battery applications because, in theory, their high elastic modulus provides better resistance to Li0 dendrite growth. However, in practice, OCEs can hardly survive critical current densities higher than 1 mA/cm2. Key issues that contribute to the breakdown of OCEs include Li0 penetration promoted by grain boundaries (GBs), uncontrolled side reactions at electrode-OCE interfaces, and, equally importantly, defects evolution (e.g., void growth and crack propagation) that leads to local current concentration and mechanical failure inside and on OCEs. Here, taking advantage of a dynamically crosslinked aprotic polymer with non-covalent –CH3⋯CF3 bonds, we developed a plastic ceramic electrolyte (PCE) by hybridizing the polymer framework with ionically conductive ceramics. Using in-situ synchrotron X-ray technique and Cryogenic transmission electron microscopy (Cryo-TEM), we uncover that the PCE exhibits self-healing/repairing capability through a two-step dynamic defects removal mechanism. This significantly suppresses the generation of hotspots for Li0 penetration and chemomechanical degradations, resulting in durability beyond 2000 hours in Li0-Li0 cells at 1 mA/cm2. Furthermore, by introducing a polyacrylate buffer layer between PCE and Li0-anode, long cycle life >3600 cycles was achieved when paired with a 4.2 V zero-strain cathode, all under near-zero stack pressure.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"69 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis Rab7a 是通过调节 GSK3β/β-Catenin/MITF 轴调控黑色素瘤进展的 TPC2 活性增强因子

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-19 DOI: 10.1038/s41467-024-54324-9

Carla Abrahamian, Rachel Tang, Rebecca Deutsch, Lina Ouologuem, Eva-Maria Weiden, Veronika Kudrina, Julia Blenninger, Julia Rilling, Colin Feldmann, Solveig Kuss, Youli Stepanov, Anna Scotto Rosato, Guadalupe T. Calvo, Maria S. Soengas, Doris Mayr, Thomas Fröhlich, Thomas Gudermann, Martin Biel, Christian Wahl-Schott, Cheng-Chang Chen, Karin Bartel, Christian Grimm

{"title":"Rab7a is an enhancer of TPC2 activity regulating melanoma progression through modulation of the GSK3β/β-Catenin/MITF-axis","authors":"Carla Abrahamian, Rachel Tang, Rebecca Deutsch, Lina Ouologuem, Eva-Maria Weiden, Veronika Kudrina, Julia Blenninger, Julia Rilling, Colin Feldmann, Solveig Kuss, Youli Stepanov, Anna Scotto Rosato, Guadalupe T. Calvo, Maria S. Soengas, Doris Mayr, Thomas Fröhlich, Thomas Gudermann, Martin Biel, Christian Wahl-Schott, Cheng-Chang Chen, Karin Bartel, Christian Grimm","doi":"10.1038/s41467-024-54324-9","DOIUrl":"https://doi.org/10.1038/s41467-024-54324-9","url":null,"abstract":"Melanoma arising from pigment-producing melanocytes is the deadliest form of skin cancer. Extensive ultraviolet light exposure is a major cause of melanoma and individuals with low levels of melanin are at particular risk. Humans carrying gain-of-function polymorphisms in the melanosomal/endolysosomal two-pore cation channel TPC2 present with hypopigmentation, blond hair, and albinism. Loss of TPC2 is associated with decreased cancer/melanoma proliferation, migration, invasion, tumor growth and metastasis formation, and TPC2 depleted melanoma cells show increased levels of melanin. How TPC2 activity is controlled in melanoma and the downstream molecular effects of TPC2 activation on melanoma development remain largely elusive. Here we show that the small GTPase Rab7a strongly enhances the activity of TPC2 and that effects of TPC2 on melanoma hallmarks, in vitro and in vivo strongly depend on the presence of Rab7a, which controls TPC2 activity to modulate GSK3β, β-Catenin, and MITF, a major regulator of melanoma development and progression.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"9 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nuclear receptor-SINE B1 network modulates expanded pluripotency in blastoids and blastocysts 核受体-SINE B1 网络调节胚泡和囊胚的扩大多能性

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-19 DOI: 10.1038/s41467-024-54381-0

Ka Wai Wong, Yingying Zeng, Edison Tay, Jia Hao Jackie Teo, Nadia Omega Cipta, Kiyofumi Hamashima, Yao Yi, Haijun Liu, Tushar Warrier, Minh T. N. Le, Soon Chye Ng, Qi-Jing Li, Hu Li, Yuin-Han Loh

{"title":"Nuclear receptor-SINE B1 network modulates expanded pluripotency in blastoids and blastocysts","authors":"Ka Wai Wong, Yingying Zeng, Edison Tay, Jia Hao Jackie Teo, Nadia Omega Cipta, Kiyofumi Hamashima, Yao Yi, Haijun Liu, Tushar Warrier, Minh T. N. Le, Soon Chye Ng, Qi-Jing Li, Hu Li, Yuin-Han Loh","doi":"10.1038/s41467-024-54381-0","DOIUrl":"https://doi.org/10.1038/s41467-024-54381-0","url":null,"abstract":"Embryonic stem cells possess the remarkable ability to self-organize into blastocyst-like structures upon induction. These stem cell-based embryo models serve as invaluable platforms for studying embryogenesis and therapeutic developments. Nevertheless, the specific intrinsic regulators that govern this potential for blastoid formation remain unknown. Here we demonstrate an intrinsic program that plays a crucial role in both blastoids and blastocysts across multiple species. We first establish metrics for grading the resemblance of blastoids to mouse blastocysts, and identify the differential activation of gene regulons involved in lineage specification among various blastoid grades. Notably, abrogation of nuclear receptor subfamily 1, group H, member 2 (Nr1h2) drastically reduces blastoid formation. Nr1h2 activation alone is sufficient to rewire conventional ESC into a distinct pluripotency state, enabling them to form blastoids with enhanced implantation capacity in the uterus and contribute to both embryonic and extraembryonic lineages in vivo. Through integrative multi-omics analyses, we uncover the broad regulatory role of Nr1h2 in the transcriptome, chromatin accessibility and epigenome, targeting genes associated with embryonic lineage and the transposable element SINE-B1. The Nr1h2-centred intrinsic program governs and drives the development of both blastoids and early embryos.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Predicting standardized uptake value of brown adipose tissue from CT scans using convolutional neural networks 作者更正：利用卷积神经网络从 CT 扫描预测棕色脂肪组织的标准化摄取值

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-19 DOI: 10.1038/s41467-024-54209-x

Ertunc Erdil, Anton S. Becker, Moritz Schwyzer, Borja Martinez-Tellez, Jonatan R. Ruiz, Thomas Sartoretti, H. Alberto Vargas, A. Irene Burger, Alin Chirindel, Damian Wild, Nicola Zamboni, Bart Deplancke, Vincent Gardeux, Claudia Irene Maushart, Matthias Johannes Betz, Christian Wolfrum, Ender Konukoglu

引用次数: 0

Acute canopy deficits in global cities exposed by the 3-30-300 benchmark for urban nature 城市自然 3-30-300 基准暴露出全球城市树冠严重不足的问题

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-19 DOI: 10.1038/s41467-024-53402-2

Thami Croeser, Roshan Sharma, Wolfgang W. Weisser, Sarah A. Bekessy

引用次数: 0

Pervasive fire danger continued under a negative emission scenario 在负排放情景下，火灾危险依然普遍存在

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-11-19 DOI: 10.1038/s41467-024-54339-2

Hyo-Jeong Kim, Jin-Soo Kim, Soon-Il An, Jongsoo Shin, Ji-Hoon Oh, Jong-Seong Kug

{"title":"Pervasive fire danger continued under a negative emission scenario","authors":"Hyo-Jeong Kim, Jin-Soo Kim, Soon-Il An, Jongsoo Shin, Ji-Hoon Oh, Jong-Seong Kug","doi":"10.1038/s41467-024-54339-2","DOIUrl":"https://doi.org/10.1038/s41467-024-54339-2","url":null,"abstract":"Enhanced fire-prone weather under greenhouse gas warming can significantly affect local and global carbon budgets from increased fire occurrence, influencing carbon-climate feedbacks. However, the extent to which changes in fire-prone weather and associated carbon emissions can be mitigated by negative emissions remains uncertain. Here, we analyze fire weather responses in CO2 removal climate model experiments and estimate their potential carbon emissions based on an observational relationship between fire weather and fire-induced CO2 emissions. The results highlight that enhanced fire danger under global warming cannot be restored instantaneously by CO2 reduction, mainly due to atmospheric dryness maintained by climatic inertia. The exacerbated fire danger is projected to contribute to extra CO2 emissions in 68% of global regions due to the hysteresis of climate responses to CO2 levels. These findings highlight that even under global cooling from negative emissions, increased fire activity may reinforce the fire-carbon-climate feedback loop and result in further socio-economic damage.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"18 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0