Nature Communications最新文献_第10页

Author Correction: Iron sulfide-catalyzed gaseous CO2 reduction and prebiotic carbon fixation in terrestrial hot springs

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-12-06 DOI: 10.1038/s41467-024-55040-0

Jingbo Nan, Shunqin Luo, Quoc Phuong Tran, Albert C. Fahrenbach, Wen-Ning Lu, Yingjie Hu, Zongjun Yin, Jinhua Ye, Martin J. Van Kranendonk

引用次数: 0

Author Correction: Untangling lineage introductions, persistence and transmission drivers of HP-PRRSV sublineage 8.7

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-12-06 DOI: 10.1038/s41467-024-54697-x

Yankuo Sun, Jiabao Xing, Samuel L. Hong, Nena Bollen, Sijia Xu, Yue Li, Jianhao Zhong, Xiaopeng Gao, Dihua Zhu, Jing Liu, Lang Gong, Lei Zhou, Tongqing An, Mang Shi, Heng Wang, Guy Baele, Guihong Zhang

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Myosin VI drives arrestin-independent internalization and signaling of GPCRs

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-12-06 DOI: 10.1038/s41467-024-55053-9

Nishaben M. Patel, Léa Ripoll, Chloe J. Peach, Ning Ma, Emily E. Blythe, Nagarajan Vaidehi, Nigel W. Bunnett, Mark von Zastrow, Sivaraj Sivaramakrishnan

{"title":"Myosin VI drives arrestin-independent internalization and signaling of GPCRs","authors":"Nishaben M. Patel, Léa Ripoll, Chloe J. Peach, Ning Ma, Emily E. Blythe, Nagarajan Vaidehi, Nigel W. Bunnett, Mark von Zastrow, Sivaraj Sivaramakrishnan","doi":"10.1038/s41467-024-55053-9","DOIUrl":"https://doi.org/10.1038/s41467-024-55053-9","url":null,"abstract":"G protein-coupled receptor (GPCR) endocytosis is canonically associated with β-arrestins. Here, we delineate a β-arrestin-independent endocytic pathway driven by the cytoskeletal motor, myosin VI. Myosin VI engages GIPC, an adaptor protein that binds a PDZ sequence motif present at the C-terminus of several GPCRs. Using the D2 dopamine receptor (D2R) as a prototype, we find that myosin VI regulates receptor endocytosis, spatiotemporal localization, and signaling. We find that access to the D2R C-tail for myosin VI-driven internalization is controlled by an interaction between the C-tail and the third intracellular loop of the receptor. Agonist efficacy, co-factors, and GIPC expression modulate this interaction to tune agonist trafficking. Myosin VI is differentially regulated by distinct GPCR C-tails, suggesting a mechanism to shape spatiotemporal signaling profiles in different ligand and physiological contexts. Our biophysical and structural insights may advance orthogonal therapeutic strategies for targeting GPCRs through cytoskeletal motor proteins.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"5 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Charge stripe manipulation of superconducting pairing symmetry transition

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-12-06 DOI: 10.1038/s41467-024-54682-4

Chao Chen, Peigeng Zhong, Xuelei Sui, Runyu Ma, Ying Liang, Shijie Hu, Tianxing Ma, Hai-Qing Lin, Bing Huang

引用次数: 0

Photonic diffractive generators through sampling noises from scattering media

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-12-06 DOI: 10.1038/s41467-024-55058-4

Ziyu Zhan, Hao Wang, Qiang Liu, Xing Fu

{"title":"Photonic diffractive generators through sampling noises from scattering media","authors":"Ziyu Zhan, Hao Wang, Qiang Liu, Xing Fu","doi":"10.1038/s41467-024-55058-4","DOIUrl":"https://doi.org/10.1038/s41467-024-55058-4","url":null,"abstract":"Photonic computing, with potentials of high parallelism, low latency and high energy efficiency, have gained progressive interest at the forefront of neural network (NN) accelerators. However, most existing photonic computing accelerators concentrate on discriminative NNs. Large-scale generative photonic computing machines remain largely unexplored, partly due to poor data accessibility, accuracy and hardware feasibility. Here, we harness random light scattering in disordered media as a native noise source and leverage large-scale diffractive optical computing to generate images from above noise, thereby achieving hardware consistency by solely pursuing the spatial parallelism of light. To realize experimental data accessibility, we design two encoding strategies between images and optical noise latent space that effectively solves the training problem. Furthermore, we utilize advanced photonic NN architectures including cascaded and parallel configurations of diffraction layers to enhance the image generation performance. Our results show that the photonic generator is capable of producing clear and meaningful synthesized images across several standard public datasets. As a photonic generative machine, this work makes an important contribution to photonic computing and paves the way for more sophisticated applications such as real world data augmentation and multi modal generation.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"12 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triboelectric sensor with ultra-wide linear range based on water-containing elastomer and ion-rich interface

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-12-06 DOI: 10.1038/s41467-024-54980-x

Siyao Qin, Peng Yang, Zhaoqi Liu, Jun Hu, Ning Li, Liming Ding, Xiangyu Chen

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A pause in the weakening of the Atlantic meridional overturning circulation since the early 2010s

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-12-06 DOI: 10.1038/s41467-024-54903-w

Sang-Ki Lee, Dongmin Kim, Fabian A. Gomez, Hosmay Lopez, Denis L. Volkov, Shenfu Dong, Rick Lumpkin, Stephen Yeager

{"title":"A pause in the weakening of the Atlantic meridional overturning circulation since the early 2010s","authors":"Sang-Ki Lee, Dongmin Kim, Fabian A. Gomez, Hosmay Lopez, Denis L. Volkov, Shenfu Dong, Rick Lumpkin, Stephen Yeager","doi":"10.1038/s41467-024-54903-w","DOIUrl":"https://doi.org/10.1038/s41467-024-54903-w","url":null,"abstract":"The current state-of-the-art climate models when combined together suggest that the anthropogenic weakening of the Atlantic Meridional Overturning Circulation (AMOC) has already begun since the mid-1980s. However, continuous direct observational records during the past two decades have shown remarkable resilience of the AMOC. To shed light on this apparent contradiction, here we attempt to attribute the interdecadal variation of the historical AMOC to the anthropogenic and natural signals, by analyzing multiple climate and surface-forced ocean model simulations together with direct observational data. Our analysis suggests that an extensive weakening of the AMOC occurred in the 2000s, as evident from the surface-forced ocean model simulations, and was primarily driven by anthropogenic forcing and possibly augmented by natural variability. However, since the early 2010s, the natural component of the AMOC has greatly strengthened due to the development of a strong positive North Atlantic Oscillation. The enhanced natural AMOC signal in turn acted to oppose the anthropogenic weakening signal, leading to a near stalling of the AMOC weakening. Further analysis suggests that the tug-of-war between the natural and anthropogenic signals will likely continue in the next several years.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"138 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Annexin- and calcium-regulated priming of legume root cells for endosymbiotic infection

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-12-06 DOI: 10.1038/s41467-024-55067-3

Ambre Guillory, Joëlle Fournier, Audrey Kelner, Karen Hobecker, Marie-Christine Auriac, Lisa Frances, Anaïs Delers, Léa Pedinotti, Aurélie Le Ru, Jean Keller, Pierre-Marc Delaux, Caroline Gutjahr, Nicolas Frei Dit Frey, Fernanda de Carvalho-Niebel

{"title":"Annexin- and calcium-regulated priming of legume root cells for endosymbiotic infection","authors":"Ambre Guillory, Joëlle Fournier, Audrey Kelner, Karen Hobecker, Marie-Christine Auriac, Lisa Frances, Anaïs Delers, Léa Pedinotti, Aurélie Le Ru, Jean Keller, Pierre-Marc Delaux, Caroline Gutjahr, Nicolas Frei Dit Frey, Fernanda de Carvalho-Niebel","doi":"10.1038/s41467-024-55067-3","DOIUrl":"https://doi.org/10.1038/s41467-024-55067-3","url":null,"abstract":"Legumes establish endosymbioses with arbuscular mycorrhizal (AM) fungi or rhizobia bacteria to improve mineral nutrition. Symbionts are hosted in privileged habitats, root cortex (for AM fungi) or nodules (for rhizobia) for efficient nutrient exchange. To reach these habitats, plants form cytoplasmic cell bridges, key to predicting and guiding fungal hyphae or rhizobia-filled infection thread (IT) root entry. However, the underlying mechanisms are poorly studied. Here we show that unique ultrastructural changes and calcium (Ca2+) spiking signatures, closely associated with Medicago truncatula Annexin 1 (MtAnn1) accumulation, accompany rhizobia-related bridge formation. Loss of MtAnn1 function in M. truncatula affects Ca2+ spike amplitude, cytoplasmic configuration and rhizobia infection efficiency, consistent with a role of MtAnn1 in regulating infection priming. MtAnn1, which evolved in species establishing intracellular symbioses, is also AM-symbiosis-induced and required for proper arbuscule formation. Together, we propose that MtAnn1 is part of an ancient Ca2+-regulatory module for transcellular endosymbiotic infection.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"20 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: ITER full model in MCNP for radiation safety demonstration

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-12-06 DOI: 10.1038/s41467-024-54683-3

R. Juarez, M. Belotti, A. Kolsek, V. López, J. Alguacil, G. Pedroche, A. J. López-Revelles, P. Martínez-Albertos, M. De Pietri, P. Guijosa, Y. Le Tonqueze, M. J. Loughlin, E. Polunovskiy, R. Pampin, M. Fabbri, J. Sanz

引用次数: 0

Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2024-12-06 DOI: 10.1038/s41467-024-54877-9

Ahmed E. I. Hamouda, Jessica Filtjens, Elisabeth Brabants, Daliya Kancheva, Ayla Debraekeleer, Jan Brughmans, Lotte Jacobs, Pauline M. R. Bardet, Elisabeth Knetemann, Pierre Lefesvre, Lize Allonsius, Mark Gontsarik, Ismael Varela, Marian Crabbé, Emile J. Clappaert, Federica Cappellesso, Aarushi A. Caro, Alícia Gordún Peiró, Luna Fredericq, Eva Hadadi, Mariona Estapé Senti, Raymond Schiffelers, Leo A. van Grunsven, Frank Aboubakar Nana, Bruno G. De Geest, Sofie Deschoemaeker, Stefaan De Koker, Florence Lambolez, Damya Laoui

{"title":"Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity","authors":"Ahmed E. I. Hamouda, Jessica Filtjens, Elisabeth Brabants, Daliya Kancheva, Ayla Debraekeleer, Jan Brughmans, Lotte Jacobs, Pauline M. R. Bardet, Elisabeth Knetemann, Pierre Lefesvre, Lize Allonsius, Mark Gontsarik, Ismael Varela, Marian Crabbé, Emile J. Clappaert, Federica Cappellesso, Aarushi A. Caro, Alícia Gordún Peiró, Luna Fredericq, Eva Hadadi, Mariona Estapé Senti, Raymond Schiffelers, Leo A. van Grunsven, Frank Aboubakar Nana, Bruno G. De Geest, Sofie Deschoemaeker, Stefaan De Koker, Florence Lambolez, Damya Laoui","doi":"10.1038/s41467-024-54877-9","DOIUrl":"https://doi.org/10.1038/s41467-024-54877-9","url":null,"abstract":"Local delivery of mRNA-based immunotherapy offers a promising avenue as it enables the production of specific immunomodulatory proteins that can stimulate the immune system to recognize and eliminate cancer cells while limiting systemic exposure and toxicities. Here, we develop and employ lipid-based nanoparticles (LNPs) to intratumorally deliver an mRNA mixture encoding the cytokines interleukin (IL)−21 and IL-7 and the immunostimulatory molecule 4-1BB ligand (Triplet LNP). IL-21 synergy with IL-7 and 4-1BBL leads to a profound increase in the frequency of tumor-infiltrating CD8+ T cells and their capacity to produce granzyme B and IFN-γ, leading to tumor eradication and the development of long-term immunological memory. Mechanistically, the efficacy of the Triplet LNP depends on tumor-draining lymph nodes to tumor CD8+ T-cell trafficking. Moreover, we highlight the therapeutic potential of the Triplet LNP in multiple tumor models in female mice and its superior therapeutic efficacy to immune checkpoint blockade. Ultimately, the expression of these immunomodulators is associated with better overall survival in patients with cancer.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"38 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0