Nature Communications最新文献

{"title":"Pharmacological and physiological activation of TGR5 in the NTS lowers food intake by enhancing leptin-STAT3 signaling","authors":"Kyla Bruce, Song-Yang Zhang, Ameth N. Garrido, Melissa T. Wang, Tomás P. Bachor, Pengcheng Wang, Allison W. Xu, Zeyu Yang, Tony K. T. Lam","doi":"10.1038/s41467-025-60331-1","DOIUrl":"https://doi.org/10.1038/s41467-025-60331-1","url":null,"abstract":"<p>Feeding increases plasma bile acid levels while the nucleus of the solitary tract (NTS) and area postrema (AP) of the brain detect changes in hormones to regulate feeding. However, whether an increase in bile acids activates Takeda G protein-coupled receptor 5 (TGR5) in the NTS and/or AP to lower feeding through a negative feedback pathway is unknown. Here, we discover that infusion of TGR5 agonist CCDC in the NTS of male rats lowered food intake without causing conditional taste avoidance in short-term high fat (HF) fed male rats in association with HF-induced increase in TGR5 expression in the NTS. In contrast, CCDC infusion into the AP failed to lower food intake in HF rats with a reduction in TGR5 expression in the AP. CCDC infusion in the NTS activates TGR5 to reverse HF-induced leptin resistance by enhancing a leptin-leptin receptor-STAT3 signaling axis selectively in the NTS to lower feeding. Finally, metabolomic analysis indicated that HF impaired a refeeding-induced rise of endogenous TGR5 ligand deoxycholic acid in the plasma and subsequently in the NTS in association with hyperphagia, while direct infusion of deoxycholic acid in the NTS of HF rats activated TGR5 to lower feeding and enhanced leptin-STAT3 signaling, thereby altogether demonstrating physiological and pharmacological activation of TGR5 in the NTS regulates food intake. In summary, we discover that an activation of TGR5 in the NTS enhances leptin-STAT3 signaling to lower food intake. Our findings highlight the potential of targeting TGR5 to reverse leptin resistance in the NTS.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"26 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of noble metal nanoarrays via agglomeration and metallurgy for acidic water electrolysis","authors":"Jiawei Tao, Ruiqin Gao, Geyu Lin, Chaoyang Chu, Yan Sun, Chunyang Yu, Yanhang Ma, Huibin Qiu","doi":"10.1038/s41467-025-60419-8","DOIUrl":"https://doi.org/10.1038/s41467-025-60419-8","url":null,"abstract":"<p>Noble metal electrocatalysts remain the mainstay for proton exchange membrane water electrolysis, majorly due to their exceptional activity and durability in acidic media. However, conventional powder and particle catalysts intensively suffer from aggregation, shedding and poor electron conductivity in practical applications. Here, we develop a micellar brush-guided method to agglomerate and smelt metal nanoparticles into erect nanoarrays with designable constitutions on various substrates. While the nanoarrays of stacked nanoparticles show poor stability in the acidic media, the smelting treatment substantially enhances the electron conductivity by more than four order of magnitude and reinforces the nanoarray architectures. This allows the tailored fabrication of self-supported acid-durable metallic and alloy nanoarray catalysts with outstanding hydrogen evolution activity, and metal oxide nanoarray with extraordinary oxygen evolution activity. The integration of metallic Ru-nanoarray and RuO_x-nanoarray in a proton exchange membrane electrolyzer further enables a long-term stable water electrolysis process for more than 500 h at 1 A cm⁻².</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"29 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cell-context response to germ layer differentiation signals is predetermined by the epigenome in regionalized epiblast populations","authors":"Niels Alvaro Menezes, Kathryn Johanna Peterson, Xiaogang Guo, Veronica Castiglioni, Adrija Kalvisa, Katarzyna Filimonow, Karen Schachter, Christina Maria Schuh, Athanasios Pasias, Luca Mariani, Joshua Mark Brickman, Jakub Sedzinski, Elisabetta Ferretti","doi":"10.1038/s41467-025-60348-6","DOIUrl":"https://doi.org/10.1038/s41467-025-60348-6","url":null,"abstract":"<p>Stem cells hold promise in regenerative medicine as they have the potential to differentiate into a variety of specialized cell types. However, mechanisms underlying stem cell potency and lineage acquisition remain elusive. Epigenetic modifications and genome accessibility prime cellular feedback to signalling cues, influencing lineage differentiation outcomes. Deciphering how this epigenetic code influences the context-dependent response of pluripotent cells to differentiation cues will elucidate how mammalian tissue diversity is established. Using in vitro and in vivo models, we show that lineage-specific epigenetic signatures precede transcriptional activation of germ layer differentiation programs. We provide evidence that while distinct chromatin accessibility and methylome states prime extraembryonic mesodermal fate decisions, it is DNA methylation, and not chromatin accessibility that predetermines the fates of neuroectoderm, definitive endoderm and neuromesodermal lineages. This study establishes that epigenetic machinery fine-tunes epiblast potency, allowing context-specific spatiotemporal responses to promiscuously used signalling cues controlling organogenesis.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"5 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-performance Ag2Se-based thermoelectrics for wearable electronics","authors":"Lin Zhang, Xiao-Lei Shi, Hongjing Shang, Hongwei Gu, Wenyi Chen, Meng Li, Daxing Huang, Hao Dong, Xiaolei Wang, Fazhu Ding, Zhi-Gang Chen","doi":"10.1038/s41467-025-60284-5","DOIUrl":"https://doi.org/10.1038/s41467-025-60284-5","url":null,"abstract":"<p>Flexible thermoelectric materials and devices hold enormous potential for wearable electronics but are hindered by inadequate material properties and inefficient assembly techniques, leading to suboptimal performance. Herein, we developed a flexible thermoelectric film, comprising Ag₂Se nanowires as the primary material, a nylon membrane as a flexible scaffold, and reduced graphene oxide as a conductive network, achieving a record-high room-temperature <i>ZT</i> of 1.28. Hot-pressed Ag₂Se nanowires exhibited strong (013) orientation, enhancing carrier mobility and electrical conductivity. Dispersed reduced graphene oxide further boosts electrical conductivity and induces an energy-filtering effect, decoupling electrical conductivity and the Seebeck coefficient to achieve an impressive power factor of 37 μW cm⁻¹ K⁻² at 300 K. The high-intensity between Ag₂Se and reduced graphene oxide interfaces enhance phonon scattering, effectively reducing thermal conductivity to below 0.9 W m⁻¹ K⁻¹ and enabling the high <i>ZT</i> value. The nylon membrane endowed the film with exceptional flexibility. A large-scale out-of-plane device with 100 pairs of thermoelectric legs, assembled from these films, delivers an ultrahigh normalized power density of &gt;9.8 μW cm⁻² K⁻², outperforming all reported Ag₂Se-based flexible devices. When applied to the human body, the device generated sufficient power to operate a thermo-hygrometer and a wristwatch, demonstrating its practical potential for wearable electronics.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"5 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"scMODAL: a general deep learning framework for comprehensive single-cell multi-omics data alignment with feature links","authors":"Gefei Wang, Jia Zhao, Yingxin Lin, Tianyu Liu, Yize Zhao, Hongyu Zhao","doi":"10.1038/s41467-025-60333-z","DOIUrl":"https://doi.org/10.1038/s41467-025-60333-z","url":null,"abstract":"<p>Recent advancements in single-cell technologies have enabled comprehensive characterization of cellular states through transcriptomic, epigenomic, and proteomic profiling at single-cell resolution. These technologies have significantly deepened our understanding of cell functions and disease mechanisms from various omics perspectives. As these technologies evolve rapidly and data resources expand, there is a growing need for computational methods that can integrate information from different modalities to facilitate joint analysis of single-cell multi-omics data. However, integrating single-cell omics datasets presents unique challenges due to varied feature correlations and technology-specific limitations. To address these challenges, we introduce scMODAL, a deep learning framework tailored for single-cell multi-omics data alignment using feature links. scMODAL integrates datasets with limited known positively correlated features, leveraging neural networks and generative adversarial networks to align cell embeddings and preserve feature topology. Our experiments demonstrate scMODAL’s effectiveness in removing unwanted variation, preserving biological information, and accurately identifying cell subpopulations across diverse datasets. scMODAL not only advances integration tasks but also supports downstream analyses such as feature imputation and feature relationship inference, offering a robust solution for advancing single-cell multi-omics research.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"15 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lunar dichotomy in surface water storage of impact glass beads","authors":"Huicun He, Sen Hu, Liang Gao, Ruiying Li, Jialong Hao, Ross N. Mitchell, Kai Lu, Yubing Gao, Linxi Li, Mengfan Qiu, Zhan Zhou, Wei Yang, Shuhui Cai, Yi Chen, Lihui Jia, Qiu-Li Li, Hejiu Hui, Yangting Lin, Xian-Hua Li, Fu-Yuan Wu","doi":"10.1038/s41467-025-60388-y","DOIUrl":"https://doi.org/10.1038/s41467-025-60388-y","url":null,"abstract":"<p>Water is the one of most precious resources for planetary utilisation. Lunar nearside impact glass beads (IGBs) have been demonstrated to contain abundant solar wind-derived water (SW-H₂O); however, little is known about its farside counterpart. Here, we report the water abundances and hydrogen isotope compositions and their distribution in farside IGBs collected by the Chang’e-6 mission to investigate the role of IGBs in the lunar surface water cycle. Farside IGBs are found to have water abundances of ~10–1,070 μg.g⁻¹ with hydrogen isotopes (δD) ranging from –988‰ to &gt;2000‰ and display typical SW-H₂O hydration profiles. The SW-H₂O hydration depths in farside IGBs are strikingly shallower than in nearside IGBs. Moreover, the hydration profiles are only found in mare IGBs, with none observed in non-mare IGBs, indicating that SW-H₂O hydration in IGBs is likely composition dependent. These findings indicate that SW-H₂O storage of IGBs exhibits a dichotomy distribution in lunar soils.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"5 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts","authors":"Philip K. Ehrenberg, Aviva Geretz, Meta Volcic, Taisuke Izumi, Lauren K. Yum, Adam Waickman, Shida Shangguan, Dominic Paquin-Proulx, Matthew Creegan, Meera Bose, Kawthar Machmach, Aidan McGraw, Akshara Narahari, Jeffrey R. Currier, Carlo Sacdalan, Nittaya Phanuphak, Richard Apps, Michael Corley, Lishomwa C. Ndhlovu, Bonnie Slike, Shelly J. Krebs, Jintanat Anonworanich, Sodsai Tovanabutra, Merlin L. Robb, Michael A. Eller, Gregory M. Laird, Joshua Cyktor, Eric S. Daar, Trevor A. Crowell, John W. Mellors, Sandhya Vasan, Nelson L. Michael, Frank Kirchhoff, Rasmi Thomas","doi":"10.1038/s41467-025-59833-9","DOIUrl":"https://doi.org/10.1038/s41467-025-59833-9","url":null,"abstract":"<p>Eliminating latent HIV-1 is a major goal of AIDS research but host factors determining the size of these reservoirs are poorly understood. Here, we investigate the role of host gene expression on HIV-1 reservoir size during suppressive antiretroviral therapy (ART). Peripheral blood cells of fourteen males initiating ART during acute infection and demonstrating effective viral suppression but varying magnitudes of total HIV-1 DNA were characterized by single-cell RNA sequencing. Differential expression analysis demonstrates increased CD14+ monocyte activity in participants having undetectable HIV-1 reservoirs, with <i>IL1B</i> expression inversely associating with reservoir size. This is validated in another cohort of 38 males comprised of different ancestry and HIV-1 subtypes, and with intact proviral DNA assay (IPDA®) measurements. Modeling interactions show monocyte <i>IL1B</i> expression associates inversely with reservoir size at higher frequencies of central memory CD4+ T cells, linking monocyte <i>IL1B</i> expression to cell types known to be reservoirs for persistent HIV-1. Functional analyses reveal that IL1B activates NF-κB, thereby promoting productive HIV-1 infection while simultaneously suppressing viral spread, suggesting a natural latency reversing activity to deplete the reservoir in ART-treated individuals. Altogether, scRNA-seq analyses reveal that monocyte <i>IL1B</i> expression could decrease HIV-1 proviral reservoirs in individuals initiating ART during acute infection.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"5 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualizing hot carrier dynamics by nonlinear optical spectroscopy at the atomic length scale","authors":"Yang Luo, Shaoxiang Sheng, Andrea Schirato, Alberto Martin-Jimenez, Giuseppe Della Valle, Giulio Cerullo, Klaus Kern, Manish Garg","doi":"10.1038/s41467-025-60384-2","DOIUrl":"https://doi.org/10.1038/s41467-025-60384-2","url":null,"abstract":"<p>Probing and manipulating the spatiotemporal dynamics of hot carriers in nanoscale metals is crucial to a plethora of applications ranging from nonlinear nanophotonics to single-molecule photochemistry. The direct investigation of these highly non-equilibrium carriers requires the experimental capability of high energy-resolution (~ meV) broadband femtosecond spectroscopy. When considering the ultimate limits of atomic-scale structures, this capability has remained out of reach until date. Using a two-color femtosecond pump-probe spectroscopy, we present here the real-time tracking of hot carrier dynamics in a well-defined plasmonic picocavity, formed in the tunnel junction of a scanning tunneling microscope (STM). The excitation of hot carriers in the picocavity enables ultrafast all-optical control over the broadband (~ eV) anti-Stokes electronic resonance Raman scattering (ERRS) and the four-wave mixing (FWM) signals generated at the atomic length scale. By mapping the ERRS and FWM signals from a single graphene nanoribbon (GNR), we demonstrate that both signals are more efficiently generated along the edges of the GNR — a manifestation of atomic-scale nonlinear optical microscopy.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"5 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of the α-emitting isotope 210Pa","authors":"M. M. Zhang, J. G. Wang, L. Ma, Z. G. Gan, Z. Y. Zhang, M. H. Huang, H. B. Yang, C. L. Yang, A. N. Andreyev, C. X. Yuan, Y. L. Tian, Y. S. Wang, J. Y. Wang, Y. H. Qiang, X. L. Wu, S. Y. Xu, Z. Zhao, X. Y. Huang, Z. C. Li, H. Zhou, X. Zhang, G. Xie, L. Zhu, F. Guan, J. H. Zheng, L. C. Sun, Y. J. Li, H. R. Yang, L. M. Duan, Z. W. Lu, W. X. Huang, L. T. Sun, Y. He, H. S. Xu, Y. F. Niu, X. T. He, Z. Z. Ren, S. G. Zhou","doi":"10.1038/s41467-025-60047-2","DOIUrl":"https://doi.org/10.1038/s41467-025-60047-2","url":null,"abstract":"<p>Synthesizing isotopes located far away from the line of <i>β</i>-stability is the core research topic in nuclear physics. However, it remains a challenge due to their tiny production cross sections and short half-lives. Here, we report on the observation of a very neutron-deficient isotope ²¹⁰Pa produced via the fusion-evaporation reaction ¹⁷⁵Lu(⁴⁰Ca, 5n)²¹⁰Pa at a newly constructed China Accelerator Facility for Superheavy Elements. The measured <i>α</i>-particle energy of <i>E</i>_<i>α</i> = 8284(15) keV and half-life of <span>({T}_{1/2}=6.{0}_{-1.1}^{+1.5})</span> ms of ²¹⁰Pa allow us to extend the <i>α</i>-decay systematics and test the predictive power of theoretical models for heavy nuclei near the proton drip line. Based on its unhindered <i>α</i>-decay character, the spin and parity of ²¹⁰Pa is proposed to be (3⁺), supported by the large-scale shell model and cranked shell model calculations. This isotope is discovered with substantial statics within <span>∼</span> 3 days using intensive 2 p<i>μ</i>A beam, demonstrating the tremendous capability of the facility for the study of heavy and superheavy nuclei.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"35 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kramers nodal lines in intercalated TaS2 superconductors","authors":"Yichen Zhang, Yuxiang Gao, Aki Pulkkinen, Xingyao Guo, Jianwei Huang, Yucheng Guo, Ziqin Yue, Ji Seop Oh, Alex Moon, Mohamed Oudah, Xue-Jian Gao, Alberto Marmodoro, Alexei Fedorov, Sung-Kwan Mo, Makoto Hashimoto, Donghui Lu, Anil Rajapitamahuni, Elio Vescovo, Junichiro Kono, Alannah M. Hallas, Robert J. Birgeneau, Luis Balicas, Ján Minár, Pavan Hosur, Kam Tuen Law, Emilia Morosan, Ming Yi","doi":"10.1038/s41467-025-60020-z","DOIUrl":"https://doi.org/10.1038/s41467-025-60020-z","url":null,"abstract":"<p>Kramers degeneracy is one fundamental embodiment of the quantum mechanical nature of particles with half-integer spin under time reversal symmetry. Under the chiral and noncentrosymmetric achiral crystalline symmetries, Kramers degeneracy emerges respectively as topological quasiparticles of Weyl fermions and Kramers nodal lines (KNLs), anchoring the Berry phase-related physics of electrons. However, an experimental demonstration for ideal KNLs well isolated at the Fermi level is lacking. Here, we establish a class of noncentrosymmetric achiral intercalated transition metal dichalcogenide superconductors with large Ising-type spin-orbit coupling, represented by In_<i>x</i>TaS₂, to host an ideal KNL phase. We provide evidence from angle-resolved photoemission spectroscopy with spin resolution, angle-dependent quantum oscillation measurements, and ab-initio calculations. Our work not only provides a realistic platform for realizing and tuning KNLs in layered materials, but also paves the way for exploring the interplay between KNLs and superconductivity, as well as applications pertaining to spintronics, valleytronics, and nonlinear transport.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"19 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144165015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}