Nature Communications最新文献_第9页

Partnerships with Indigenous Peoples for an ethical bioeconomy

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-03-27 DOI: 10.1038/s41467-025-57935-y

Maria C. T. Astolfi, WarīNkwī Flores, Rolando Perez, Ulises J. Espinoza, Teal B. Zimring, Jay D. Keasling, Keolu Fox

引用次数: 0

Operando X-ray absorption spectroscopic investigation of electrocatalysts state in anion exchange membrane fuel cells.

IF 14.7 1区综合性期刊

Nature Communications Pub Date : 2025-03-27 DOI: 10.1038/s41467-025-57177-y

Qihao Li, Christopher J Pollock, Joesene Soto, Andrés Molina Villarino, Zixiao Shi, Mihail R Krumov, David A Muller, Héctor D Abruña

{"title":"Operando X-ray absorption spectroscopic investigation of electrocatalysts state in anion exchange membrane fuel cells.","authors":"Qihao Li, Christopher J Pollock, Joesene Soto, Andrés Molina Villarino, Zixiao Shi, Mihail R Krumov, David A Muller, Héctor D Abruña","doi":"10.1038/s41467-025-57177-y","DOIUrl":"https://doi.org/10.1038/s41467-025-57177-y","url":null,"abstract":"Capturing the active state of (electro)catalysts under operating conditions, namely operando, is the ultimate objective of (electro)catalyst characterization, enabling the unraveling of reaction mechanisms and advancing (electro)catalyst development. Operando insights advance our understanding of the correlations between electrochemical tests and device-level performances. However, operando characterization of electrocatalysts is challenging due to the complexity of electrochemical devices and instrumental limitations. As a result, the majority of electrocatalyst characterizations have been limited to half-cell in situ studies. Here, we present an operando X-ray absorption spectroscopic study of Mn spinel oxide electrocatalysts in an operating fuel cell employing a custom-designed cell. Our results reveal that in anion exchange membrane fuel cells, the Mn valence state, within spinel Mn3O4/C, increases to above 3+, adopting an octahedral coordination devoid of Jahn-Teller distortions. This structural change results in an AEMFC performance equivalent to that of Co1.5Mn1.5O4/C, a composition that outperforms Mn3O4/C in rotating disk electrode tests. Our results underscore the importance of operando characterizations in elucidating the active state of electrocatalysts and understanding the correlation(s) between electrochemical tests and device performance.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"3008"},"PeriodicalIF":14.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143731070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lanthanide single-atom catalysts for efficient CO2-to-CO electroreduction

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-03-27 DOI: 10.1038/s41467-025-57464-8

Qiyou Wang, Tao Luo, Xueying Cao, Yujie Gong, Yuxiang Liu, Yusen Xiao, Hongmei Li, Franz Gröbmeyer, Ying-Rui Lu, Ting-Shan Chan, Chao Ma, Kang Liu, Junwei Fu, Shiguo Zhang, Changxu Liu, Zhang Lin, Liyuan Chai, Emiliano Cortes, Min Liu

{"title":"Lanthanide single-atom catalysts for efficient CO2-to-CO electroreduction","authors":"Qiyou Wang, Tao Luo, Xueying Cao, Yujie Gong, Yuxiang Liu, Yusen Xiao, Hongmei Li, Franz Gröbmeyer, Ying-Rui Lu, Ting-Shan Chan, Chao Ma, Kang Liu, Junwei Fu, Shiguo Zhang, Changxu Liu, Zhang Lin, Liyuan Chai, Emiliano Cortes, Min Liu","doi":"10.1038/s41467-025-57464-8","DOIUrl":"https://doi.org/10.1038/s41467-025-57464-8","url":null,"abstract":"Single-atom catalysts (SACs) have received increasing attention due to their 100% atomic utilization efficiency. The electrochemical CO2 reduction reaction (CO2RR) to CO using SAC offers a promising approach for CO2 utilization, but achieving facile CO2 adsorption and CO desorption remains challenging for traditional SACs. Instead of singling out specific atoms, we propose a strategy utilizing atoms from the entire lanthanide (Ln) group to facilitate the CO2RR. Density functional theory calculations, operando spectroscopy, and X-ray absorption spectroscopy elucidate the bridging adsorption mechanism for a representative erbium (Er) single-atom catalyst. As a result, we realize a series of Ln SACs spanning 14 elements that exhibit CO Faradaic efficiencies exceeding 90%. The Er catalyst achieves a high turnover frequency of ~130,000 h−1 at 500 mA cm−2. Moreover, 34.7% full-cell energy efficiency and 70.4% single-pass CO2 conversion efficiency are obtained at 200 mA cm−2 with acidic electrolyte. This catalytic platform leverages the collective potential of the lanthanide group, introducing new possibilities for efficient CO2-to-CO conversion and beyond through the exploration of unique bonding motifs in single-atom catalysts.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"21 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Independent origins and non-parallel selection signatures of triclabendazole resistance in Fasciola hepatica

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-03-27 DOI: 10.1038/s41467-025-57796-5

Young-Jun Choi, Bruce A. Rosa, Martha V. Fernandez-Baca, Rodrigo A. Ore, John Martin, Pedro Ortiz, Cristian Hoban, Miguel M. Cabada, Makedonka Mitreva

{"title":"Independent origins and non-parallel selection signatures of triclabendazole resistance in Fasciola hepatica","authors":"Young-Jun Choi, Bruce A. Rosa, Martha V. Fernandez-Baca, Rodrigo A. Ore, John Martin, Pedro Ortiz, Cristian Hoban, Miguel M. Cabada, Makedonka Mitreva","doi":"10.1038/s41467-025-57796-5","DOIUrl":"https://doi.org/10.1038/s41467-025-57796-5","url":null,"abstract":"Triclabendazole (TCBZ) is the primary treatment for fascioliasis, a global foodborne zoonosis caused by Fasciola hepatica. Widespread resistance to TCBZ (TCBZ-R) in livestock and a rapid rise in resistant human infections are significant concerns. To understand the genetic basis of TCBZ-R, we sequenced the genomes of 99 TCBZ-sensitive (TCBZ-S) and 210 TCBZ-R adult flukes from 146 bovine livers in Cusco, Peru. We identify genomic regions of high differentiation (FST outliers above the 99.9th percentile) that encod genes involved in the EGFR-PI3K-mTOR-S6K pathway and microtubule function. Transcript expression differences are observed in microtubule-related genes between TCBZ-S and -R flukes, both without drug treatment and in response to treatment. Using only 30 SNPs, it is possible to differentiate between TCBZ-S and -R parasites with ≥75% accuracy. Our outlier loci are distinct from the previously reported TCBZ-R-associated QTLs in the UK, suggesting an independent evolution of resistance alleles. Effective genetics-based TCBZ-R surveillance must consider the heterogeneity of loci under selection across diverse geographical populations.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"31 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-03-27 DOI: 10.1038/s41467-025-58137-2

Leyla Abbasova, Paulina Urbanaviciute, Di Hu, Joy N. Ismail, Brian M. Schilder, Alexi Nott, Nathan G. Skene, Sarah J. Marzi

{"title":"CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks","authors":"Leyla Abbasova, Paulina Urbanaviciute, Di Hu, Joy N. Ismail, Brian M. Schilder, Alexi Nott, Nathan G. Skene, Sarah J. Marzi","doi":"10.1038/s41467-025-58137-2","DOIUrl":"https://doi.org/10.1038/s41467-025-58137-2","url":null,"abstract":"DNA-protein interactions have traditionally been profiled via chromatin immunoprecipitation followed by next-generation sequencing (ChIP-seq). Cleavage Under Targets & Tagmentation (CUT&Tag) is a rapidly expanding technique that enables the profiling of such interactions in situ at high sensitivity. However, thorough evaluation and benchmarking against established ChIP-seq datasets are lacking. Here, we comprehensively benchmarked CUT&Tag for H3K27ac and H3K27me3 against published ChIP-seq profiles from ENCODE in K562 cells. Combining multiple new and published CUT&Tag datasets, there was an average recall of 54% known ENCODE peaks for both histone modifications. We tested peak callers MACS2 and SEACR and identified optimal peak calling parameters. Overall, peaks identified by CUT&Tag represent the strongest ENCODE peaks and show the same functional and biological enrichments as ChIP-seq peaks identified by ENCODE. Our workflow systematically evaluates the merits of methodological adjustments, providing a benchmarking framework for the experimental design and analysis of CUT&Tag studies.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"35 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD248-targeted BBIR-T cell therapy against late-activated fibroblasts in cardiac repair after myocardial infarction

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-03-27 DOI: 10.1038/s41467-025-56703-2

Haiting Chen, Ke Hu, Qi Tang, Junzhuo Wang, Qianyu Gu, Jiayu Chen, Jiaxin Hu, Ningxin Peng, Meng Guo, Yaohui Jiang, Qingbo Xu, Jun Xie

引用次数: 0

SIMVI disentangles intrinsic and spatial-induced cellular states in spatial omics data

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-03-27 DOI: 10.1038/s41467-025-58089-7

Mingze Dong, David G. Su, Harriet Kluger, Rong Fan, Yuval Kluger

{"title":"SIMVI disentangles intrinsic and spatial-induced cellular states in spatial omics data","authors":"Mingze Dong, David G. Su, Harriet Kluger, Rong Fan, Yuval Kluger","doi":"10.1038/s41467-025-58089-7","DOIUrl":"https://doi.org/10.1038/s41467-025-58089-7","url":null,"abstract":"Spatial omics technologies enable analysis of gene expression and interaction dynamics in relation to tissue structure and function. However, existing computational methods may not properly distinguish cellular intrinsic variability and intercellular interactions, and may thus fail to reliably capture spatial regulations. Here, we present Spatial Interaction Modeling using Variational Inference (SIMVI), an annotation-free deep learning framework that disentangles cell intrinsic and spatial-induced latent variables in spatial omics data with rigorous theoretical support. By this disentanglement, SIMVI enables estimation of spatial effects at a single-cell resolution, and empowers various downstream analyses. We demonstrate the superior performance of SIMVI across datasets from diverse platforms and tissues. SIMVI illuminates the cyclical spatial dynamics of germinal center B cells in human tonsil. Applying SIMVI to multiome melanoma data reveals potential tumor epigenetic reprogramming states. On our newly-collected cohort-level CosMx melanoma data, SIMVI uncovers space-and-outcome-dependent macrophage states and cellular communication machinery in tumor microenvironments.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"24 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-effectiveness of community-based integrated care model for patients with diabetes and depressive symptoms

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-03-27 DOI: 10.1038/s41467-025-58120-x

Wanshang Wang, Dan Guo, Yiqi Xia, Mingzheng Hu, Ming Wang, Zhenyu Shi, Xiaolong Guan, Dawei Zhu, Ping He

{"title":"Cost-effectiveness of community-based integrated care model for patients with diabetes and depressive symptoms","authors":"Wanshang Wang, Dan Guo, Yiqi Xia, Mingzheng Hu, Ming Wang, Zhenyu Shi, Xiaolong Guan, Dawei Zhu, Ping He","doi":"10.1038/s41467-025-58120-x","DOIUrl":"https://doi.org/10.1038/s41467-025-58120-x","url":null,"abstract":"The coexistence of type 2 diabetes (T2DM) and depression is a prominent example of multimorbidity. In previous work, we reported the results of a completed cluster-randomized controlled trial that was conducted in eight community health centers in China. We enrolled adults (≥18 years) with type 2 diabetes and depressive symptoms. In the intervention group, a comprehensive care plan was developed based on the Integrated Care Model for Patients with Diabetes and Depression (CIC-PDD). In this study, we explore the cost-effectiveness of the CIC-PDD by conducting a one-year within-trial economic evaluation from the health system, multipayer and societal perspectives. Health outcomes are quality-adjusted life years (QALYs) and depression-free days (DFDs), and we calculate incremental cost-effectiveness ratios (ICERs) and cost-effectiveness probability. Among 630 participants (275 intervention, 355 usual care), the cost per QALY gained is $7,922.82, $7,823.85, and $7,409.46, with cost-effectiveness probabilities of 66.41%- 94.45%. The cost per DFD is $2.63–$2.82, requiring a willingness-to-pay of $9.00–$10.50 for >95% probability of cost-effectiveness. We find that the CIC-PDD model demonstrates cost-effectiveness within primary health care settings, but further studies are needed to assess its long-term sustainability and scalability. Trial registration: 35 ChiCTR2200065608.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"99 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratin-72 restricts HIV-1 infection in resting CD4+ T cells by sequestering capsids in intermediate filaments

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-03-27 DOI: 10.1038/s41467-025-58218-2

Yang He, Meng Xu, Jiayue Ouyang, Li Zhao, Tiankui Ma, Xiaowei Zhang, Ruolin Wang, Hong Shang, Guoxin Liang

{"title":"Keratin-72 restricts HIV-1 infection in resting CD4+ T cells by sequestering capsids in intermediate filaments","authors":"Yang He, Meng Xu, Jiayue Ouyang, Li Zhao, Tiankui Ma, Xiaowei Zhang, Ruolin Wang, Hong Shang, Guoxin Liang","doi":"10.1038/s41467-025-58218-2","DOIUrl":"https://doi.org/10.1038/s41467-025-58218-2","url":null,"abstract":"The accessory protein Vpx from the red-capped mangabey or mandrill SIV (SIVrcm/mnd-2) lineage has been reported to increase HIV-1 infection in resting CD4+ T cells without affecting SAMHD1, a known target of Vpx in HIV-1 infection. This indicates that Vpx, in addition to SAMHD1, circumvents other restriction factors for lentiviruses. To identify potential restriction factors, this study examined cellular proteins interacting with Vpxrcm and found that keratin-72 (KRT72), an intermediate filament (IF) protein expressed in resting CD4+ T cells, is a host antiviral factor targeted by Vpx. Vpxrcm/mnd-2 lineages could strongly promote KRT72 degradation, resulting in increased HIV-1 infection in resting CD4+ T cells. We discovered that KRT72 restricts HIV-1 replication by sequestering incoming HIV-1 capsids in cytoplasmic IFs. With KRT72, the capsid cores of HIV-1 become attached to IFs, and their trafficking toward the nucleus is inhibited. In contrast, without KRT72, HIV-1 capsids are transported to the nucleus, leading to high levels of integrated HIV-1 DNA. Thus, KRT72 is a Vpx-counteracted antiviral factor that binds the incoming capsids to cytoplasmic IFs, restricting HIV-1 infection in resting CD4+ T cells.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"11 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pronounced decline in northern vegetation resistance to flash droughts from 2001 to 2022

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-03-27 DOI: 10.1038/s41467-025-58253-z

Miao Zhang, Xing Yuan, Zhenzhong Zeng, Ming Pan, Peili Wu, Jingfeng Xiao, Trevor F. Keenan

{"title":"A pronounced decline in northern vegetation resistance to flash droughts from 2001 to 2022","authors":"Miao Zhang, Xing Yuan, Zhenzhong Zeng, Ming Pan, Peili Wu, Jingfeng Xiao, Trevor F. Keenan","doi":"10.1038/s41467-025-58253-z","DOIUrl":"https://doi.org/10.1038/s41467-025-58253-z","url":null,"abstract":"Climate change has led to the transition of droughts into rapid and intensified phenomena known as flash droughts, presenting considerable challenges for risk management, particularly concerning their impact on ecosystem productivity. Quantifying the ecosystem’s capacity to maintain productivity during flash droughts, referred to as ecosystem resistance, is crucial to assess drought impacts. However, it remains uncertain how the resistance of ecosystem productivity to flash drought changes over time. Here we show that vegetation resistance to flash droughts declines by up to 27% (±5%) over the Northern Hemisphere hotspots during 2001-2022, including eastern Asia, western North America, and northern Europe. The notable decline in vegetation resistance is mainly attributed to increased vapour pressure deficit and temperature, and enhanced vegetation structural sensitivity to water availability. Flash droughts pose higher ecological risks than slowly-developing droughts during the growing seasons, where ecosystem productivity experiences faster decline rates with a shorter response time. Our results underscore the limited ecosystem capacity to resist flash droughts under climate change.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"88 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0