Nature Communications最新文献

{"title":"Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.","authors":"Boya Guo, Yanwei Cai, Daeeun Kim, Roelof A J Smit, Zhe Wang, Kruthika R Iyer, Austin T Hilliard, Jeffrey Haessler, Ran Tao, K Alaine Broadaway, Yujie Wang, Nikita Pozdeyev, Frederik F Stæger, Chaojie Yang, Brett Vanderwerff, Amit D Patki, Lauren Stalbow, Meng Lin, Nicholas Rafaels, Jonathan Shortt, Laura Wiley, Maggie Stanislawski, Jack Pattee, Lea Davis, Peter S Straub, Megan M Shuey, Nancy J Cox, Nanette R Lee, Marit E Jørgensen, Peter Bjerregaard, Christina Larsen, Torben Hansen, Ida Moltke, James B Meigs, Daniel O Stram, Xianyong Yin, Xiang Zhou, Kyong-Mi Chang, Shoa L Clarke, Rodrigo Guarischi-Sousa, Joanna Lankester, Philip S Tsao, Steven Buyske, Mariaelisa Graff, Laura M Raffield, Quan Sun, Lynne R Wilkens, Christopher S Carlson, Charles B Easton, Simin Liu, JoAnn E Manson, Loïc L Marchand, Christopher A Haiman, Karen L Mohlke, Penny Gordon-Larsen, Anders Albrechtsen, Michael Boehnke, Stephen S Rich, Ani Manichaikul, Jerome I Rotter, Noha A Yousri, Ryan M Irvin, Chris Gignoux, Kari E North, Ruth J F Loos, Themistocles L Assimes, Ulrike Peters, Charles Kooperberg, Sridharan Raghavan, Heather M Highland, Burcu F Darst","doi":"10.1038/s41467-025-63546-4","DOIUrl":"https://doi.org/10.1038/s41467-025-63546-4","url":null,"abstract":"<p><p>Polygenic risk scores hold prognostic value for identifying individuals at higher risk of type 2 diabetes. However, further characterization is needed to understand the generalizability of type 2 diabetes polygenic risk scores in diverse populations across various contexts. We systematically characterize a multi-ancestry type 2 diabetes polygenic risk score among 244,637 cases and 637,891 controls across diverse populations from the Population Architecture Genomics and Epidemiology Study and 13 additional biobanks and cohorts. Polygenic risk score performance is context dependent, with better performance in those who are younger, male, without hypertension, and not obese or overweight. Additionally, the polygenic risk score is associated with various diabetes-related cardiometabolic traits and type 2 diabetes complications, suggesting its utility for stratifying risk of complications and identifying shared genetic architecture between type 2 diabetes and other diseases. These findings highlight the need to account for context when evaluating polygenic risk score as a tool for type 2 diabetes risk prognostication and the potentially generalizable associations of type 2 diabetes polygenic risk score with diabetes-related traits, despite differential performance in type 2 diabetes prediction across diverse populations. Our study provides a comprehensive resource to characterize a type 2 diabetes polygenic risk score.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8632"},"PeriodicalIF":15.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Salt-templated transformation of waste plastics into single-atom catalysts for environmental and energy applications.","authors":"Shiying Ren, Xin Xu, Kunsheng Hu, Shuang Zhong, Yingjie Gao, Bernt Johannessen, Wei Ren, Hongyu Zhou, Zhong-Shuai Zhu, Yidi Chen, Xiaoguang Duan, Shaobin Wang","doi":"10.1038/s41467-025-64721-3","DOIUrl":"https://doi.org/10.1038/s41467-025-64721-3","url":null,"abstract":"","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8766"},"PeriodicalIF":15.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twisted bilayer Ice as a new class of hydrogen-bonding moiré materials.","authors":"Liya Wang, Jian Jiang, Siyi Liu, Shuying Lin, Jiajie Yan, YinBo Zhu, Jun Xia, Ruijie Wang, Chengyuan Wang, Chun Tang, Xiao Cheng Zeng","doi":"10.1038/s41467-025-63833-0","DOIUrl":"https://doi.org/10.1038/s41467-025-63833-0","url":null,"abstract":"<p><p>Twisted bilayer van der Waals materials have become a transformative framework for the design of quantum and electronic devices, yet their counterparts, the twisted bilayer non-van der Waals materials, remain largely unexplored. Here, we report the first molecular-dynamics simulation evidence of the spontaneous formation of twisted bilayer ice with moiré patterns. Unlike the twisted bilayer van der Waals materials which can be produced by manually twisting one monolayer relative to another, twisted-bilayer-ice formation hinges on the structural adaptability of hydrogen bonds to achieve thermodynamic stability. First-principles molecular-dynamics simulations confirm the thermal stability of the twisted bilayer ice with two different moiré patterns, one with commensurate twist angle of 21.8° and another 27.8°. A phase diagram illustrates the stability region of twisted bilayer ice, providing guidance for future experimental validation. This work not only expands the family of two-dimensional ices but also advances the notion of twisted bilayer hydrogen-bonding materials, thereby offering opportunities to investigate emergent properties and potential applications of twisted bilayer non-van der Waals materials.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8762"},"PeriodicalIF":15.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial attention selectively alters visual cortical representation during target anticipation.","authors":"Ekin Tünçok, Marisa Carrasco, Jonathan Winawer","doi":"10.1038/s41467-025-63795-3","DOIUrl":"https://doi.org/10.1038/s41467-025-63795-3","url":null,"abstract":"<p><p>Attention enables us to efficiently and flexibly interact with the environment by prioritizing specific image locations and features in preparation for responding to stimuli. Using a concurrent psychophysics-fMRI experiment, we investigate how covert spatial attention modulates responses in human visual cortex before target onset and how it affects subsequent behavioral performance. Performance improves at cued locations and worsens at uncued locations compared to distributed attention, demonstrating a selective processing tradeoff. Pre-target BOLD responses in cortical visual field maps reveal two key changes: First, a stimulus-independent baseline shift, with increases near cued locations and decreases elsewhere, paralleling behavioral results. Second, a shift in population receptive field centers toward the attended location. Both effects increase in higher visual areas. Together, these findings reveal that spatial attention has large effects on visual cortex prior to target appearance, altering neural response properties across multiple visual field maps and enhancing performance through anticipatory mechanisms.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8746"},"PeriodicalIF":15.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transfer learning via distributed brain recordings enables reliable speech decoding.","authors":"Aditya Singh, Tessy Thomas, Jinlong Li, Greg Hickok, Xaq Pitkow, Nitin Tandon","doi":"10.1038/s41467-025-63825-0","DOIUrl":"https://doi.org/10.1038/s41467-025-63825-0","url":null,"abstract":"<p><p>Speech brain-computer interfaces (BCIs) combine neural recordings with large language models to achieve real-time intelligible speech. However, these decoders rely on dense, intact cortical coverage and are challenging to scale across individuals with heterogeneous brain organization. To derive scalable transfer learning strategies for neural speech decoding, we used minimally invasive stereo-electroencephalography recordings in a large cohort performing a demanding speech motor task. A sequence-to-sequence model enabled decoding of variable-length phonemic sequences prior to and during articulation. This enabled development of a cross-subject transfer learning framework to isolate shared latent manifolds while enabling individual model initialization. The group-derived decoder significantly outperformed models trained on individual data alone, enabling decoding robustness despite variable coverage and activation. These results highlight a pathway toward generalizable neural prostheses for speech and language disorders by leveraging large-scale intracranial datasets with distributed spatial sampling and shared task demands.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8749"},"PeriodicalIF":15.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-persisting SARS-CoV-2 spike-specific CD4⁺ T cells associated with mild disease and increased cytotoxicity post COVID-19.","authors":"Guihai Liu, Elie Antoun, Anastasia Fries, Xuan Yao, Zixi Yin, Danning Dong, Wenbo Wang, Peter A C Wing, Wanwisa Dejnirattisa, Piyada Supasa, Chang Liu, Timothy Rostron, Craig Waugh, Kevin Clark, Paul Sopp, Jeremy W Fry, Iolanda Vendrell, Jane A McKeating, Juthathip Mongkolsapaya, Gavin R Screaton, Benedikt M Kessler, Roman Fisher, Graham Ogg, Alexander J Mentzer, Julian C Knight, Yanchun Peng, Tao Dong","doi":"10.1038/s41467-025-63711-9","DOIUrl":"https://doi.org/10.1038/s41467-025-63711-9","url":null,"abstract":"<p><p>The recent COVID-19 pandemic left behind the lingering question as whether new variants of concern might cause further waves of infection. Thus, it is important to investigate the long-term protection gained via vaccination or exposure to the SARS-CoV-2 virus. Here we compare the evolution of memory T-cell responses following primary infection with subsequent antigen exposures. Single-cell TCR analysis of three dominant SARS-CoV-2 spike-specific CD4⁺ T-cell responses identifies the dominant public TCRα clonotypes pairing with diverse TCRβ clonotypes that associated with mild disease at primary infection. These clonotypes are found at higher frequencies in pre-pandemic repertoires compared to other epitope-specific clonotypes. Longitudinal transcriptomics and TCR analysis, combined with functional evaluation, reveals that the clonotypes persisting 3-4 years post initial infection exhibit distinct functionality compared to those that were lost. Furthermore, spike-specific CD4⁺ T cells at this time point show decreased Th1 signatures and enhanced GZMA-driven cytotoxic transcriptomic profiles that were independent of TCR clonotype and associated with viral suppression. In summary, we identify common public TCRs used by immunodominant spike-specific memory CD4⁺ T-cells, associated with mild disease outcome, which likely play important protective roles to subsequent viral infection events.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8743"},"PeriodicalIF":15.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scalable solution-processed ferroelectric polymers exhibiting markedly enhanced piezoelectricity.","authors":"Ze Yuan,Hui Tong,Zekai Fei,Chenyi Li,Yang Liu","doi":"10.1038/s41467-025-63849-6","DOIUrl":"https://doi.org/10.1038/s41467-025-63849-6","url":null,"abstract":"Intensive efforts have been made to enhance the weak piezoelectric coefficients of ferroelectric polymers for flexible and wearable devices. However, previous approaches are highly dependent on synthesis of desired composition and complex/hash processing conditions while the scalability remains rarely addressed limiting practical applicability. Here we report large piezoelectric coefficient d33 in scalable solution-processed ferroelectric poly(vinylidene fluoride-co-trifluoroethylene) copolymers modified by C=C and C=O double bonds. We reveal that the introduction of C=C double bonds tune the energetic competition between ordered and disordered crystalline conformations. As a result, greatly enhanced d33 of -90.5 pC N-1 and dielectric constant of 22.7 are achieved, corresponding to about 3 times and 2 times as large as that of benchmark poly(vinylidene fluoride). We fabricate flexible and wearable sensors enabling detection of various signals such as pressure and sound with high sensitivity, which find promise in pressure mapping, health monitoring and acoustic sensing applications.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"101 1","pages":"8758"},"PeriodicalIF":16.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-cleavage of the GAIN domain of adhesion G protein-coupled receptors requires multiple domain-extrinsic factors.","authors":"Yin Kwan Chung,Christian H Ihling,Lina Zielke,Signe Mathiasen,Andrea Sinz,Tobias Langenhan","doi":"10.1038/s41467-025-64589-3","DOIUrl":"https://doi.org/10.1038/s41467-025-64589-3","url":null,"abstract":"The autoproteolysis-inducing (GAIN) domain of class B2/adhesion G protein-coupled receptors (aGPCRs) is structurally conserved, and its self-cleavage is central to receptor mechanotransduction and signaling. Yet, the influence of factors beyond the protein fold on GAIN domain autoproteolysis remains unclear. Using ADGRE2/EMR2, a self-cleaved aGPCR, we investigated contributions of the seven-transmembrane (7TM) region to GAIN domain autoproteolysis during receptor maturation and trafficking. Retention Upon Selective Hook (RUSH) assays showed that self-cleavage acts as a checkpoint before endoplasmic reticulum (ER) exit, but not during plasma membrane transport. Stepwise truncations of the 7TM domain revealed that cleavage can occur before or at synthesis of the first transmembrane helix, and is enhanced with formation of the full 7TM domain. Analyses of six additional cleavage-competent aGPCRs demonstrated that ER membrane tethering facilitates GAIN domain processing, supported by proteomic evidence linking cleavage to proximity with the N-glycosylation pathway. These results highlight the interplay between GAIN and 7TM domains, offering mechanistic insights and guiding pharmacological strategies to modulate aGPCR activation and signaling.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"78 1","pages":"8736"},"PeriodicalIF":16.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HY5 integrates light and electrical signaling to trigger a jasmonate burst for nematode defense in tomato.","authors":"Ting Sun,Chaoyi Hu,Changan Zhu,Jiaxing Cai,Guoting Wang,Xiaojian Xia,Kai Shi,Yanhong Zhou,Jingquan Yu,Christine H Foyer,Jie Zhou","doi":"10.1038/s41467-025-63779-3","DOIUrl":"https://doi.org/10.1038/s41467-025-63779-3","url":null,"abstract":"Plants have evolved sophisticated defense systems to protect against herbivory, including the systemic induction of jasmonic acid (JA) synthesis. However, the molecular mechanisms underlying this process remain poorly understood. Here, we report that root-knot nematode (RKN) attack induced a phyB-dependent accumulation of ELONGATED HYPOCOTYL 5 (HY5) in the leaves, which activates the expression of JA biosynthesis genes and HY5 itself in tomato. In addition, the systemic transmission of GLUTAMATE RECEPTOR-LIKE 3.5 (GLR3.5)-dependent electrical signals induced by RKN triggers the physical interaction between CALMODULIN 2 (CaM2) and HY5 to amplify the transcriptional regulation of HY5 and JA synthesis. HY5 functions as a systemic signal that moves from leaves to roots to maintain the electrical signaling from roots to leaves by activating GLR3.5 expression. Together, these results reveal a HY5-dependent systemic signaling cascade that integrates light and electrical signals to activate JA-mediated defense against nematodes in tomato.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"9 1","pages":"8750"},"PeriodicalIF":16.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolving chemical-motif similarity with enhanced atomic structure representations for accurately predicting descriptors at metallic interfaces.","authors":"Cheng Cai,Tao Wang","doi":"10.1038/s41467-025-63860-x","DOIUrl":"https://doi.org/10.1038/s41467-025-63860-x","url":null,"abstract":"Accurately predicting catalytic descriptors with machine learning (ML) methods is significant to achieving accelerated catalyst design, where a unique representation of the atomic structure of each system is the key to developing a universal, efficient, and accurate ML model that is capable of tackling diverse degrees of complexity in heterogeneous catalysis scenarios. Herein, we integrate equivariant message-passing-enhanced atomic structure representation to resolve chemical-motif similarity in highly complex catalytic systems. Our developed equivariant graph neural network (equivGNN) model achieves mean absolute errors <0.09 eV for different descriptors at metallic interfaces, including complex adsorbates with more diverse adsorption motifs on ordered catalyst surfaces, adsorption motifs on highly disordered surfaces of high-entropy alloys, and the complex structures of supported nanoparticles. The prediction accuracy and easy implementation attained by our model across various systems demonstrate its robustness and potentially broad applicability, laying a reasonable basis for achieving accelerated catalyst design.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"124 1","pages":"8761"},"PeriodicalIF":16.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}