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Liquid-matter relaxor ferroelectrics by design. 设计的液态弛豫铁电体。
IF 15.7 1区 综合性期刊
Nature Communications Pub Date : 2025-10-22 DOI: 10.1038/s41467-025-64421-y
Xinxin Zhang, Yu Zou, Minghui Deng, Xiang Huang, Fan Ye, Xiujuan Liu, Erxiang Xu, Yang Shen, Satoshi Aya, Mingjun Huang
{"title":"Liquid-matter relaxor ferroelectrics by design.","authors":"Xinxin Zhang, Yu Zou, Minghui Deng, Xiang Huang, Fan Ye, Xiujuan Liu, Erxiang Xu, Yang Shen, Satoshi Aya, Mingjun Huang","doi":"10.1038/s41467-025-64421-y","DOIUrl":"https://doi.org/10.1038/s41467-025-64421-y","url":null,"abstract":"<p><p>Knowing that traditional relaxor ferroelectrics stem from crystalline materials, one may ask whether they stabilize the liquid-matter analogy. The perspective is challenging and may enable a generic design of fluidic and flexible relaxor ferroelectrics. Here, we unveil a novel polar matter state, dubbed the nematic relaxor ferroelectric, by artificially introducing polar nanoregions with nematicity into a dielectric nematic environment. We observe clear signatures of a nematic relaxor, which exhibits a high field-induced polarization of 1.1 μC·cm<sup>-2</sup> at 5 V·μm<sup>-1</sup>, over a wide temperature range (>30 K). The relaxor demonstrates two regimes: (1) stable relaxor against high electric fields (> 5 V·μm<sup>-1</sup>) at high temperatures over a 30 K range; (2) relaxor with a field-induced transition to a ferroelectric state at low temperatures. Based on the Landau-Ginzburg-Devonshire theory, we reconstruct free-energy landscapes from the electric field vs polarization curves. We observe a continuous transformation of energy landscapes from a double-well shape to a single-well shape, characterized by a broadening of the energy bottom, corresponding to a shift from nematic ferroelectrics to nematic relaxors with significant polarization fluctuations.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"9348"},"PeriodicalIF":15.7,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145346304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Self-supervised predictive learning accounts for cortical layer-specificity. 作者更正:自监督预测学习解释了皮层层特异性。
IF 15.7 1区 综合性期刊
Nature Communications Pub Date : 2025-10-22 DOI: 10.1038/s41467-025-65076-5
Kevin Kermani Nejad, Paul Anastasiades, Loreen Hertäg, Rui Ponte Costa
{"title":"Author Correction: Self-supervised predictive learning accounts for cortical layer-specificity.","authors":"Kevin Kermani Nejad, Paul Anastasiades, Loreen Hertäg, Rui Ponte Costa","doi":"10.1038/s41467-025-65076-5","DOIUrl":"https://doi.org/10.1038/s41467-025-65076-5","url":null,"abstract":"","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"9354"},"PeriodicalIF":15.7,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145346285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-coordinated Co-Ru dual-atom enables ambient ammoxidation via unlocking competitive adsorption limitations. 低配位Co-Ru双原子通过解锁竞争性吸附限制实现环境氨氧化。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-22 DOI: 10.1038/s41467-025-64418-7
Jialin Yang,Zhecheng Fang,Zhiwei Sun,Wenhua Zhou,Bing Nan,Xiaolong Liu,Zixu Ma,Renfeng Nie,Jie Fu
{"title":"Low-coordinated Co-Ru dual-atom enables ambient ammoxidation via unlocking competitive adsorption limitations.","authors":"Jialin Yang,Zhecheng Fang,Zhiwei Sun,Wenhua Zhou,Bing Nan,Xiaolong Liu,Zixu Ma,Renfeng Nie,Jie Fu","doi":"10.1038/s41467-025-64418-7","DOIUrl":"https://doi.org/10.1038/s41467-025-64418-7","url":null,"abstract":"Direct ammoxidation of biomass-derived alcohols/aldehydes to nitriles faces challenges from N-species competitive adsorption, leading to low efficiency under harsh conditions. Herein, we report the rational design of a single-nitrogen-bridged Co-Ru dual-atom catalyst (CoRu-N-C) on nitrogen-doped carbon, enabling efficient ammoxidation at ambient conditions. At 35 °C and 1 bar air, CoRu-N-C achieved 98% yield of 2-furonitrile (FAN) with 73 mmol/g-metal/h productivity, representing a 3.5-fold enhancement compared to Co-N-C, and outperforming numerous reported noble/non-noble metal catalysts. Mechanistic studies reveal synergistic O2 and imine adsorption on low-coordinated CoN3 and RuN3 sites, mitigating imine-induced oxygen activation inhibition. Specifically, the strong O₂ adsorption on CoN3 forms superoxide radicals (O2-•) via electron transfer, driving a relay mechanism with proximally adsorbed imine to accelerate overall reaction kinetics. This work provides valuable insights for the design of stable and highly efficient ammoxidation catalysts operating under mild conditions.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"58 1","pages":"9351"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of global short-term landscape fire sourced PM2.5 exposure on child cause-specific morbidity: a study in multiple countries and territories. 全球短期景观火灾源PM2.5暴露对儿童病因特异性发病率的影响:一项在多个国家和地区进行的研究
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-22 DOI: 10.1038/s41467-025-64411-0
Shuang Zhou,Yiwen Zhang,Zhengyu Yang,Rongbin Xu,Wenzhong Huang,Yao Wu,Zhihu Xu,Yuan Gao,Yanming Liu,Wenhua Yu,Pei Yu,Gongbo Chen,Ke Ju,Tingting Ye,Bo Wen,Yuxi Zhang,Michael Abramson,Lidia Morawska,Fay H Johnston,Simon Hales,Micheline S Z S Coelho,Yue Leon Guo,Jane Heyworth,Wissanupong Kliengchuay,Luke Knibbs,Eric Lavigne,Guy Marks,Patricia Matus,Geoffrey Morgan,Paulo H N Sadiva,Kraichat Tantrakarnapa,Yuming Guo,Shanshan Li
{"title":"Impact of global short-term landscape fire sourced PM2.5 exposure on child cause-specific morbidity: a study in multiple countries and territories.","authors":"Shuang Zhou,Yiwen Zhang,Zhengyu Yang,Rongbin Xu,Wenzhong Huang,Yao Wu,Zhihu Xu,Yuan Gao,Yanming Liu,Wenhua Yu,Pei Yu,Gongbo Chen,Ke Ju,Tingting Ye,Bo Wen,Yuxi Zhang,Michael Abramson,Lidia Morawska,Fay H Johnston,Simon Hales,Micheline S Z S Coelho,Yue Leon Guo,Jane Heyworth,Wissanupong Kliengchuay,Luke Knibbs,Eric Lavigne,Guy Marks,Patricia Matus,Geoffrey Morgan,Paulo H N Sadiva,Kraichat Tantrakarnapa,Yuming Guo,Shanshan Li","doi":"10.1038/s41467-025-64411-0","DOIUrl":"https://doi.org/10.1038/s41467-025-64411-0","url":null,"abstract":"Children are particularly vulnerable to landscape fire sourced fine particulate matter (LFS PM2.5), yet evidence on its health effects remains limited. Here we show that short-term exposure to LFS PM2.5 is associated with increased hospital admissions for multiple diseases in children and adolescents. We analysed daily hospital admission data from 1012 communities in seven countries/territories, linked to a high-resolution LFS PM2.5 dataset. Each 10 μg/m3 increase in LFS PM2.5 was associated with elevated risks for all-cause (1.1%), respiratory (1.9%), infectious (1.5%), cardiovascular (2.9%), neurological (2.8%), diabetes (3.7%), cancer (1.5%), and digestive (0.8%) hospital admissions. Risks for respiratory, infectious, and neurological conditions increased even at low exposure, while others rose only above 15-20 μg/m3. Children aged 5-9 years and those in lower socioeconomic areas were especially affected. These findings highlight the health burden of LFS PM2.5 in young people and the urgent need to reduce exposure and protect vulnerable populations.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"9347"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Climate change is predicted to reduce global belowground ecosystem multifunctionality. 预计气候变化将降低全球地下生态系统的多功能性。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-22 DOI: 10.1038/s41467-025-64453-4
Tiancai Zhou,Jian Sun,Chongchong Ye,Xin Jing,Eryuan Liang,Xuyang Lu,Akira S Mori,Michael E Meadows,Josep Peñuelas
{"title":"Climate change is predicted to reduce global belowground ecosystem multifunctionality.","authors":"Tiancai Zhou,Jian Sun,Chongchong Ye,Xin Jing,Eryuan Liang,Xuyang Lu,Akira S Mori,Michael E Meadows,Josep Peñuelas","doi":"10.1038/s41467-025-64453-4","DOIUrl":"https://doi.org/10.1038/s41467-025-64453-4","url":null,"abstract":"Although climate change is known to abruptly shift ecosystem functions in drylands worldwide, the global response of belowground ecosystem multifunctionality (BEMF) to future climate change remains largely unknown. Herein, we use fifteen indicators associated with key ecosystem functions (e.g., belowground productivity, nutrient pools and cycling) to evaluate global BEMF by averaging, principal component analysis, and single-threshold approaches. Our results reveal marked spatial variation in functionality across Köppen climate biomes, indicating that BEMF is higher in polar and continental biomes compared to dry and tropical biomes. We further identify an abrupt shift in global BEMF at a mean annual temperature (MAT) threshold of approximately 16.4 °C. Globally, temperature and soil pH generate strong negative effects on BEMF in MAT ≤ 16.4 °C regions, whereas precipitation and plant species richness positively dominate the dynamics of BEMF in regions where MAT > 16.4 °C. Importantly, we predict ongoing climate change to result in a 20.8% loss of global BEMF under SSP585 by 2100, particularly in temperate and continental biomes. As future climate change is projected to increase, integrating in situ experiments and Earth system models into BEMF-climate studies is critical to the conservation and sustainability of ecosystem functions.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"-1 1","pages":"9337"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulating physicochemical interfaces enables li-rich oxides based ceramic solid-state li batteries under ambient conditions. 调制物理化学界面使富锂氧化物陶瓷固态锂电池在环境条件下。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-22 DOI: 10.1038/s41467-025-64396-w
Xinchao Hu,Shuqi Shen,Jiantao Li,Jiansen Wen,Mengjian Fan,Sungsik Lee,Yinggan Zhang,Hualong Wu,Guiyang Gao,Yuanyuan Liu,Shiyu Zhang,Chengkun Zhang,Baisheng Sa,Laisen Wang,Dong-Liang Peng,Khalil Amine,Qingshui Xie
{"title":"Modulating physicochemical interfaces enables li-rich oxides based ceramic solid-state li batteries under ambient conditions.","authors":"Xinchao Hu,Shuqi Shen,Jiantao Li,Jiansen Wen,Mengjian Fan,Sungsik Lee,Yinggan Zhang,Hualong Wu,Guiyang Gao,Yuanyuan Liu,Shiyu Zhang,Chengkun Zhang,Baisheng Sa,Laisen Wang,Dong-Liang Peng,Khalil Amine,Qingshui Xie","doi":"10.1038/s41467-025-64396-w","DOIUrl":"https://doi.org/10.1038/s41467-025-64396-w","url":null,"abstract":"Li-rich layered oxides exhibit promising potential applications in high-energy-density solid-state lithium metal batteries. Nevertheless, the strong oxidative oxygen species generate at high voltage, which poses great challenges to positive electrode-side interface stability. Herein, a robust in-situ polymerization gel polymer electrolyte with bifunctional additives is designed for interface modification. These additives, include lithium difluoro(oxalate) borate and LiPO2F2, regulate the Li+ chemical environment in gel polymer electrolyte to enhance crosslink density without residual oligomer, which reduce gas generation and suppress contact loss, thus avoiding interfacial impedance divergence. Concurrently, the designed gel polymer electrolyte enables a wide electrochemical stability window (up to 4.7 V) and a high Li+ transference number (0.82). Additionally, the additives induced F- and B-rich inorganic cathode-electrolyte interphase inhibits side reactions and oxygen/transition metal loss effectively, stabilizing the chemical interface. The as-constructed Li-rich layered oxides-based ceramic solid-state lithium metal batteries with gel polymer electrolyte interface modification exert a high discharge capacity of 276.5 mAh g-1 at 30 °C without external pressure, delivering a retention of 81.7% after 100 cycles at 25 mA g-1 during 2.0-4.7 V. This work provides a guideline for developing high-voltage solid-state lithium metal batteries via interfacial design.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"11 1","pages":"9338"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding single-crystal lithium growth through solid electrolyte interphase omics. 通过固体电解质间相组学解码单晶锂生长。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-22 DOI: 10.1038/s41467-025-62166-2
Gongxun Lu,Zhiyuan Han,Lei Shi,Zhilong Wang,Mengtian Zhang,Xinru Wu,Zhihong Piao,Xiao Xiao,Shengyu Tao,Jianwei Nai,Zhijin Ju,Xuan Zhang,Yanqiang Han,Karl Luigi Loza Vidaurre,Hongyan Fu,Jinjin Li,Xinyong Tao,Guangmin Zhou
{"title":"Decoding single-crystal lithium growth through solid electrolyte interphase omics.","authors":"Gongxun Lu,Zhiyuan Han,Lei Shi,Zhilong Wang,Mengtian Zhang,Xinru Wu,Zhihong Piao,Xiao Xiao,Shengyu Tao,Jianwei Nai,Zhijin Ju,Xuan Zhang,Yanqiang Han,Karl Luigi Loza Vidaurre,Hongyan Fu,Jinjin Li,Xinyong Tao,Guangmin Zhou","doi":"10.1038/s41467-025-62166-2","DOIUrl":"https://doi.org/10.1038/s41467-025-62166-2","url":null,"abstract":"Accurately understanding the impact of solid electrolyte interphase (SEI) on lithium deposition is critical for high-energy lithium metal batteries. Yet traditional strategies, focusing solely on isolated components, fail to capture multi-constituent synergies and underlying mechanisms. To address this challenge, we introduce the concept of SEI omics and establish a dataset of cryogenic transmission electron microscopy images combined with co-localized component information. By integrating interpretable machine learning and physics-based feature selection, we decoupled the roles of SEI constituents, revealing that higher N/S/P/F content and reduced O in the SEI improve lithium deposition. Combined density functional theory and electrochemical phase-field modeling uncovered multi-scale effects of SEI components on Li growth. Results confirm that designing an inner SEI layer with high surface energy and migration ability significantly refines deposition morphology. Guided by machine learning-optimized composition, a highly disordered SEI was engineered, achieving high average Coulombic efficiency of 99.35% over 800 cycles for Li||Cu cell at 1 mA cm-2 and 1 mAh cm-2. This work establishes a universal framework for understanding SEI-coupled effects on lithium growth, offering transformative strategies for electrolyte and interface design.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"47 1","pages":"9323"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Status dystonicus is a distinct state characterized by pallidal beta-band activity. 状态失调是一种独特的状态,其特征是苍白质β带活性。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-22 DOI: 10.1038/s41467-025-64416-9
Arjun Balachandar,Lindsey M Vogt,Karim Mithani,Sebastian C Coleman,Mark Ebden,Andrea Leblanc-Miller,Sara Breitbart,Alfonso Fasano,Carolina Gorodetsky,George M Ibrahim
{"title":"Status dystonicus is a distinct state characterized by pallidal beta-band activity.","authors":"Arjun Balachandar,Lindsey M Vogt,Karim Mithani,Sebastian C Coleman,Mark Ebden,Andrea Leblanc-Miller,Sara Breitbart,Alfonso Fasano,Carolina Gorodetsky,George M Ibrahim","doi":"10.1038/s41467-025-64416-9","DOIUrl":"https://doi.org/10.1038/s41467-025-64416-9","url":null,"abstract":"Status dystonicus (SD) is a poorly known neurological emergency requiring urgent interventions, including deep brain stimulation (DBS) targeting the globus pallidus interna (GPi). The sensing capabilities of DBS electrodes provide an opportunity to study the pathophysiology of SD. Here, we study local field potentials (LFPs) from GPi-DBS electrodes implanted in a cohort of 10 children longitudinally during SD, recovery and relapse (recording range 11-1155 days). During SD, we report an increase in the periodic component of the power spectrum within the beta-band along with increases in burst amplitude compared to recordings in non-SD states. Furthermore, relapsed SD is characterized by a return of excessive beta signatures. Beta-specific LFP power is also significantly associated with worse quality-of-life scores (PedsQL, R2 = 0.695). We identify circadian pallidal beta-band periodicity in one participant with chronic narrowband beta-power recordings over months, with significant increase in power during SD. These rare recordings in children with SD point to excessive pallidal beta-band activity as a biomarker of SD. Our findings further suggest that SD is a distinct state with important implications for understanding dystonia pathophysiology, tracking dystonia states from intracranial activity and potential adaptive DBS treatments.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"105 1","pages":"9352"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tidewater cycle drives alpine glacial sediment plume geochemistry. 潮汐循环驱动高山冰川沉积物羽流地球化学。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-22 DOI: 10.1038/s41467-025-64731-1
K O Forsch,A Ruacho,S M Aarons
{"title":"Tidewater cycle drives alpine glacial sediment plume geochemistry.","authors":"K O Forsch,A Ruacho,S M Aarons","doi":"10.1038/s41467-025-64731-1","DOIUrl":"https://doi.org/10.1038/s41467-025-64731-1","url":null,"abstract":"Sediments transported by glacial meltwaters are important sources of trace-metal micronutrients for coastal microbial communities, linking cryospheric processes with ocean fertilization and biogeochemical cycles. Tidewater glacier advance-retreat cycles drive sediment fluxes and influence fjord geochemistry. Here, we used a chemical extraction method to determine the iron and manganese fertilization potential of suspended sediment-plume and iceberg-laden particulate matter from two adjacent, yet geomorphologically distinct, fjords in Southcentral Alaska. We found that the glacier retreat status underpinned the fraction of labile trace-metals within fjord surface plumes, with distinctly lower lability of metals associated with recent and rapid retreat coincident with enhanced erosion and chemical weathering. Particle size did not affect chemical lability, resulting in a well-mixed particle assemblage transported to the coastal ocean. With global tidewater glacier retreat, these results provide implications for future ecosystem fertilization via cryospheric processes and the interpretation of fjord sediment archives.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"140 1","pages":"9211"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reno-protective CT contrast nanoagent targets proximal tubular epithelium for kidney disease imaging and repair in a mouse model. 在小鼠模型中,肾保护CT造影剂靶向近端小管上皮进行肾脏疾病成像和修复。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-22 DOI: 10.1038/s41467-025-64432-9
Mingze Xu,Yuming Qi,Yexi Peng,Huixu Lu,Yiqiao Chen,Ziyuan Wang,Yuming Lin,Xingya Jiang,Bujie Du
{"title":"Reno-protective CT contrast nanoagent targets proximal tubular epithelium for kidney disease imaging and repair in a mouse model.","authors":"Mingze Xu,Yuming Qi,Yexi Peng,Huixu Lu,Yiqiao Chen,Ziyuan Wang,Yuming Lin,Xingya Jiang,Bujie Du","doi":"10.1038/s41467-025-64432-9","DOIUrl":"https://doi.org/10.1038/s41467-025-64432-9","url":null,"abstract":"| CT imaging is widely used in clinics for disease diagnosis, but its application in renal function evaluation is limited due to nonspecific distribution and nephrotoxicity of clinical iodinated contrast agents. Herein, we developed an ultrasmall renal-clearable gold nanoparticle-based CT contrast nanoagent (E-Au-Agents) coated with antioxidant L-ergothioneine, enabling reno-targeting and reno-protection for sensitive detection and effective relief of renal dysfunction in female mice. After glomerular filtration, E-Au-Agents specifically recognized OCTN1 transporters on proximal tubular epithelium, followed by clathrin-mediated endocytosis with subsequent tubular reabsorption or re-elimination pathways. This tubular-targeting was markedly enhanced in injured kidneys, allowing rapid CT detection of acute kidney injury, followed by oxidative stress suppression. Remarkably, E-Au-Agents progressively repaired injured kidneys, allowing their eventual clearance through recovered kidneys instead of long-term renal accumulation, a drawback commonly observed in other renal-clearable agents. Collectively, we developed a promising contrast agent for renal CT imaging with dual capabilities of reno-targeting and reno-protection.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"43 1","pages":"9346"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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