Nature Communications最新文献_第8页

Negative global-scale association between genetic diversity and speciation rates in mammals

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-20 DOI: 10.1038/s41467-025-56820-y

Ana C. Afonso Silva, Odile Maliet, Leandro Aristide, David Nogués-Bravo, Nathan Upham, Walter Jetz, Hélène Morlon

引用次数: 0

Semicircular canals shed light on bottleneck events in the evolution of the Neanderthal clade

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-20 DOI: 10.1038/s41467-025-56155-8

Alessandro Urciuoli, Ignacio Martínez, Rolf Quam, Juan Luis Arsuaga, Brian A. Keeling, Julia Diez-Valero, Mercedes Conde-Valverde

{"title":"Semicircular canals shed light on bottleneck events in the evolution of the Neanderthal clade","authors":"Alessandro Urciuoli, Ignacio Martínez, Rolf Quam, Juan Luis Arsuaga, Brian A. Keeling, Julia Diez-Valero, Mercedes Conde-Valverde","doi":"10.1038/s41467-025-56155-8","DOIUrl":"https://doi.org/10.1038/s41467-025-56155-8","url":null,"abstract":"Revealing the evolutionary processes which resulted in the derived morphologies that characterize the Neanderthal clade has been an important task for paleoanthropologists. One critical method to quantify evolutionary changes in the morphology of hominin populations is through evaluating morphological phenotypic diversity (i.e., disparity) in phylogenetically informative bones as a close proxy to neutral evolutionary processes. The goal of this study is to quantify the degree of disparity in the Neanderthal clade. We hypothesize that a reduction in bony labyrinth disparity is indicative of the underlying genetic variation resulting from bottleneck events. We apply a deformation-based geometric morphometric approach to investigate semicircular canal and vestibule shape of a chronologically broad sample of individuals belonging to the Neanderthal lineage. Our results identify a significant reduction in disparity after the start of Marine Isotope Stage 5 supporting our hypothesis of a late bottleneck, possibly leading to the derived morphology of Late Pleistocene Neanderthals.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"6 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ameba-inspired strategy enhances probiotic efficacy via prebound nutrient supply 受阿米巴启发的策略可通过预置营养供应增强益生菌功效

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-20 DOI: 10.1038/s41467-025-57071-7

Chao Pan, Xiuxian Jiang, Junchao Wei, Chang Liu, Min Zhang, Chuan Gao, Rongrong Chen, Canyu Yang, Bingqi Wang, Miaorong Yu, Yong Gan

{"title":"Ameba-inspired strategy enhances probiotic efficacy via prebound nutrient supply","authors":"Chao Pan, Xiuxian Jiang, Junchao Wei, Chang Liu, Min Zhang, Chuan Gao, Rongrong Chen, Canyu Yang, Bingqi Wang, Miaorong Yu, Yong Gan","doi":"10.1038/s41467-025-57071-7","DOIUrl":"https://doi.org/10.1038/s41467-025-57071-7","url":null,"abstract":"Nutrient competition with indigenous microbes or pathogens presents a significant challenge for oral probiotic efficacy. To address this issue, we develop an ameba-inspired food-carrying strategy (AIFS) by prebinding ginger-derived exosome-like nanoparticles (GELNs) onto probiotics as food depots. AIFS enables probiotics to efficiently and exclusively consume GELNs in situ, even in the presence of competing bacteria. This results in up to 21 times higher uptake efficiency compared to unengineered probiotics, dramatically accelerating probiotic proliferation. Meanwhile, AIFS potentiates probiotics’ resistance to multiple GI stressors. In a murine model of colitis, AIFS can improve the abundance of probiotics and inhibit pathogens, maintaining intestinal flora homeostasis. Additionally, it can upregulate the anti-inflammatory IL-10, reduce the proinflammatory IL-1β, and repair damaged intestinal mucus. Thereby, AIFS displays potently elevated prophylactic and therapeutic efficacy for colitis mice. This work provides a method for microbial engineering, with broad implications for microbiotherapy and gut health.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"176 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current induced electromechanical strain in thin antipolar Ag2Se semiconductor

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-20 DOI: 10.1038/s41467-025-57057-5

Hao Luo, Qi Liang, Anan Guo, Yimeng Yu, Haoyang Peng, Xiaoyi Gao, Yihao Hu, Xianli Su, Ctirad Uher, Yu Zheng, Dongwang Yang, Xiaolin Wang, Qingjie Zhang, Xinfeng Tang, Shi Liu, Gustaaf Van Tendeloo, Shujun Zhang, Jinsong Wu

{"title":"Current induced electromechanical strain in thin antipolar Ag2Se semiconductor","authors":"Hao Luo, Qi Liang, Anan Guo, Yimeng Yu, Haoyang Peng, Xiaoyi Gao, Yihao Hu, Xianli Su, Ctirad Uher, Yu Zheng, Dongwang Yang, Xiaolin Wang, Qingjie Zhang, Xinfeng Tang, Shi Liu, Gustaaf Van Tendeloo, Shujun Zhang, Jinsong Wu","doi":"10.1038/s41467-025-57057-5","DOIUrl":"https://doi.org/10.1038/s41467-025-57057-5","url":null,"abstract":"Electromechanical coupling permits energy conversion between electrical and elastic forms, with wide applications1,2. This conversion is usually observed in dielectric materials as piezoelectricity and electrostriction3,4,5,6,7. Electromechanical coupling response has also been observed in semiconductors8, however, the mechanism in semiconductors with a small bandgap remains contentious. Here we present a breakthrough discovery of a giant electromechanical strain triggered by the electric current in thin antipolar Ag2Se semiconductor. This phenomenon is made possible by the alteration of dipoles at a low current density (step I), followed by a phase transition under a moderate current density (step II), leading to a local strain of 6.7% measured by in-situ transmission electron microscopy. Our finding demonstrates that electric current has both thermal and athermal effect (e.g. alteration of dipoles and interaction of dipole vortices with the electric current). This strain allows for the concurrent control of electroelastic deformation and electric conductivity.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"69 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-20 DOI: 10.1038/s41467-025-57135-8

Dong Liu, Hannah C. Webber, Fuyun Bian, Yangfan Xu, Manjari Prakash, Xue Feng, Ming Yang, Hang Yang, In-Jee You, Liang Li, Liping Liu, Pingting Liu, Haoliang Huang, Chien-Yi Chang, Liang Liu, Sahil H. Shah, Anna La Torre, Derek S. Welsbie, Yang Sun, Xin Duan, Jeffrey Louis Goldberg, Marcus Braun, Zdenek Lansky, Yang Hu

{"title":"Optineurin-facilitated axonal mitochondria delivery promotes neuroprotection and axon regeneration","authors":"Dong Liu, Hannah C. Webber, Fuyun Bian, Yangfan Xu, Manjari Prakash, Xue Feng, Ming Yang, Hang Yang, In-Jee You, Liang Li, Liping Liu, Pingting Liu, Haoliang Huang, Chien-Yi Chang, Liang Liu, Sahil H. Shah, Anna La Torre, Derek S. Welsbie, Yang Sun, Xin Duan, Jeffrey Louis Goldberg, Marcus Braun, Zdenek Lansky, Yang Hu","doi":"10.1038/s41467-025-57135-8","DOIUrl":"https://doi.org/10.1038/s41467-025-57135-8","url":null,"abstract":"Optineurin (OPTN) mutations are linked to amyotrophic lateral sclerosis (ALS) and normal tension glaucoma (NTG), but a relevant animal model is lacking, and the molecular mechanisms underlying neurodegeneration are unknown. We find that OPTN C-terminus truncation (OPTN∆C) causes late-onset neurodegeneration of retinal ganglion cells (RGCs), optic nerve (ON), and spinal cord motor neurons, preceded by a decrease of axonal mitochondria in mice. We discover that OPTN directly interacts with both microtubules and the mitochondrial transport complex TRAK1/KIF5B, stabilizing them for proper anterograde axonal mitochondrial transport, in a C-terminus dependent manner. Furthermore, overexpressing OPTN/TRAK1/KIF5B prevents not only OPTN truncation-induced, but also ocular hypertension-induced neurodegeneration, and promotes robust ON regeneration. Therefore, in addition to generating animal models for NTG and ALS, our results establish OPTN as a facilitator of the microtubule-dependent mitochondrial transport necessary for adequate axonal mitochondria delivery, and its loss as the likely molecular mechanism of neurodegeneration.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"64 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STANCE: a unified statistical model to detect cell-type-specific spatially variable genes in spatial transcriptomics

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-20 DOI: 10.1038/s41467-025-57117-w

Haohao Su, Yuesong Wu, Bin Chen, Yuehua Cui

{"title":"STANCE: a unified statistical model to detect cell-type-specific spatially variable genes in spatial transcriptomics","authors":"Haohao Su, Yuesong Wu, Bin Chen, Yuehua Cui","doi":"10.1038/s41467-025-57117-w","DOIUrl":"https://doi.org/10.1038/s41467-025-57117-w","url":null,"abstract":"One of the major challenges in spatial transcriptomics is to detect spatially variable genes (SVGs), whose expression patterns are non-random across tissue locations. Many SVGs correlate with cell type compositions, introducing the concept of cell type-specific SVGs (ctSVGs). Existing ctSVG detection methods treat cell type-specific spatial effects as fixed effects, leading to tissue spatial rotation-dependent results. Moreover, SVGs may exhibit random spatial patterns within cell types, meaning an SVG is not always a ctSVG, and vice versa, further complicating detection. We propose STANCE, a unified statistical model for both SVGs and ctSVGs detection under a linear mixed-effect model framework that integrates gene expression, spatial location, and cell type composition information. STANCE ensures tissue rotation-invariant results, with a two-stage approach: initial SVG/ctSVG detection followed by ctSVG-specific testing. We demonstrate its performance through extensive simulations and analyses of public datasets. Downstream analyses reveal STANCE’s potential in spatial transcriptomics analysis.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A μGal MOEMS gravimeter designed with free-form anti-springs

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-20 DOI: 10.1038/s41467-025-57176-z

Shuang Wu, Wenhui Yan, Xiaoxu Wang, Qingxiong Xiao, Zhenshan Wang, Jiaxin Sun, Xinlong Yu, Yaoxian Yang, Qixuan Zhu, Guantai Yang, Zhongyang Yao, Pengfei Li, Chao Jiang, Wei Huang, Qianbo Lu

{"title":"A μGal MOEMS gravimeter designed with free-form anti-springs","authors":"Shuang Wu, Wenhui Yan, Xiaoxu Wang, Qingxiong Xiao, Zhenshan Wang, Jiaxin Sun, Xinlong Yu, Yaoxian Yang, Qixuan Zhu, Guantai Yang, Zhongyang Yao, Pengfei Li, Chao Jiang, Wei Huang, Qianbo Lu","doi":"10.1038/s41467-025-57176-z","DOIUrl":"https://doi.org/10.1038/s41467-025-57176-z","url":null,"abstract":"Gravimeter measures gravitational acceleration, which is valuable for geophysical applications such as hazard forecasting and prospecting. Gravimeters have historically been large and expensive instruments. Micro-Electro-Mechanical-System gravimeters feature small size and low cost through scaling and integration, which may allow large-scale deployment. However, current Micro-Electro-Mechanical-System gravimeters face challenges in achieving ultra-high sensitivity under fabrication tolerance and limited size. Here, we demonstrate a μGal-level Micro-Opto-Electro-Mechanical-System gravimeter by combining a freeform anti-spring design and an optical readout. A multi-stage algorithmic design approach is proposed to achieve high acceleration sensitivity without making high-aspect ratio springs. An optical grating-based readout is integrated, offering pm-level displacement sensitivity. Measurements reveal that the chip-scale sensing unit achieves a resonant frequency of 1.71 Hz and acceleration-displacement sensitivity of over 95 μm/Gal with an etching aspect ratio of smaller than 400:30. The benchmark with a commercial gravimeter PET demonstrates a self-noise of 1.1 μGal Hz−1/2 at 0.5 Hz, sub-1 μGal Hz−1/2 at 0.45 Hz, and a drift rate down to 153 μGal/day. The high performance and small size of the Micro-Opto-Electro-Mechanical-System gravimeter suggest potential applications in industrial, defense, and geophysics.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"2 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LUC7 proteins define two major classes of 5′ splice sites in animals and plants

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-20 DOI: 10.1038/s41467-025-56577-4

Connor J. Kenny, Michael P. McGurk, Sandra Schüler, Aidan Cordero, Sascha Laubinger, Christopher B. Burge

{"title":"LUC7 proteins define two major classes of 5′ splice sites in animals and plants","authors":"Connor J. Kenny, Michael P. McGurk, Sandra Schüler, Aidan Cordero, Sascha Laubinger, Christopher B. Burge","doi":"10.1038/s41467-025-56577-4","DOIUrl":"https://doi.org/10.1038/s41467-025-56577-4","url":null,"abstract":"Mutation or deletion of the U1 snRNP-associated factor LUC7L2 is associated with myeloid neoplasms, and knockout of LUC7L2 alters cellular metabolism. Here, we show that members of the LUC7 protein family differentially regulate two major classes of 5′ splice sites (5′SS) and broadly regulate mRNA splicing in both human cell lines and leukemias with LUC7L2 copy number variation. We describe distinctive 5′SS features of exons impacted by the three human LUC7 paralogs: LUC7L2 and LUC7L enhance splicing of “right-handed” 5′SS with stronger consensus matching on the intron side of the near invariant /GU, while LUC7L3 enhances splicing of “left-handed” 5′SS with stronger consensus matching upstream of the /GU. We validated our model of sequence-specific 5′SS regulation both by mutating splice sites and swapping domains between human LUC7 proteins. Evolutionary analysis indicates that the LUC7L2/LUC7L3 subfamilies evolved before the split between animals and plants. Analysis of Arabidopsis thaliana mutants confirmed that plant LUC7 orthologs possess similar specificity to their human counterparts, indicating that 5′SS regulation by LUC7 proteins is highly conserved.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"66 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ketogenic diet suppresses colorectal cancer through the gut microbiome long chain fatty acid stearate

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-20 DOI: 10.1038/s41467-025-56678-0

Mina Tsenkova, Madita Brauer, Vitaly Igorevich Pozdeev, Marat Kasakin, Susheel Bhanu Busi, Maryse Schmoetten, Dean Cheung, Marianne Meyers, Fabien Rodriguez, Anthoula Gaigneaux, Eric Koncina, Cedric Gilson, Lisa Schlicker, Diran Herebian, Martine Schmitz, Laura de Nies, Ertan Mayatepek, Serge Haan, Carine de Beaufort, Thorsten Cramer, Johannes Meiser, Carole L. Linster, Paul Wilmes, Elisabeth Letellier

{"title":"Ketogenic diet suppresses colorectal cancer through the gut microbiome long chain fatty acid stearate","authors":"Mina Tsenkova, Madita Brauer, Vitaly Igorevich Pozdeev, Marat Kasakin, Susheel Bhanu Busi, Maryse Schmoetten, Dean Cheung, Marianne Meyers, Fabien Rodriguez, Anthoula Gaigneaux, Eric Koncina, Cedric Gilson, Lisa Schlicker, Diran Herebian, Martine Schmitz, Laura de Nies, Ertan Mayatepek, Serge Haan, Carine de Beaufort, Thorsten Cramer, Johannes Meiser, Carole L. Linster, Paul Wilmes, Elisabeth Letellier","doi":"10.1038/s41467-025-56678-0","DOIUrl":"https://doi.org/10.1038/s41467-025-56678-0","url":null,"abstract":"Colorectal cancer (CRC) patients have been shown to possess an altered gut microbiome. Diet is a well-established modulator of the microbiome, and thus, dietary interventions might have a beneficial effect on CRC. An attenuating effect of the ketogenic diet (KD) on CRC cell growth has been previously observed, however the role of the gut microbiome in driving this effect remains unknown. Here, we describe a reduced colonic tumor burden upon KD consumption in a CRC mouse model with a humanized microbiome. Importantly, we demonstrate a causal relationship through microbiome transplantation into germ-free mice, whereby alterations in the gut microbiota were maintained in the absence of continued selective pressure from the KD. Specifically, we identify a shift toward bacterial species that produce stearic acid in ketogenic conditions, whereas consumers were depleted, resulting in elevated levels of free stearate in the gut lumen. This microbial product demonstrates tumor-suppressing properties by inducing apoptosis in cancer cells and decreasing colonic Th17 immune cell populations. Taken together, the beneficial effects of the KD are mediated through alterations in the gut microbiome, including, among others, increased stearic acid production, which in turn significantly reduces intestinal tumor growth.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"15 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural basis of urea transport by Arabidopsis thaliana DUR3

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-20 DOI: 10.1038/s41467-025-56943-2

Weidong An, Yiwei Gao, Laihua Liu, Qinru Bai, Jun Zhao, Yan Zhao, Xuejun C. Zhang

{"title":"Structural basis of urea transport by Arabidopsis thaliana DUR3","authors":"Weidong An, Yiwei Gao, Laihua Liu, Qinru Bai, Jun Zhao, Yan Zhao, Xuejun C. Zhang","doi":"10.1038/s41467-025-56943-2","DOIUrl":"https://doi.org/10.1038/s41467-025-56943-2","url":null,"abstract":"Urea is a primary nitrogen source used as fertilizer in agricultural plant production and a crucial nitrogen metabolite in plants, playing an essential role in modern agriculture. In plants, DUR3 is a proton-driven high-affinity urea transporter located on the plasma membrane. It not only absorbs external low-concentration urea as a nutrient but also facilitates nitrogen transfer by recovering urea from senescent leaves. Despite its importance, the high-affinity urea transport mechanism in plants remains insufficiently understood. In this study, we determine the structures of Arabidopsis thaliana DUR3 in two different conformations: the inward-facing open state of the apo structure and the occluded urea-bound state, with overall resolutions of 2.8 Å and 3.0 Å, respectively. By comparing these structures and analyzing their functional characteristics, we elucidated how urea molecules are specifically recognized. In the urea-bound structure, we identified key titratable amino acid residues and proposed a model for proton involvement in urea transport based on structural and functional data. This study enhances our understanding of proton-driven urea transport mechanisms in DUR3.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"6 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0