Nature Communications最新文献_第8页

Discrete Immolative Guanidinium Transporters deliver mRNA to specific organs and red blood cells 离散献祭性胍转运体将mRNA传递到特定的器官和红细胞

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-08-01 DOI: 10.1038/s41467-025-62200-3

Zhijian Li, Aloysius Ee, Laura Amaya, Jennifer L. Hamad, Pavan K. Yadav, Sean K. Wang, Howard Y. Chang, Paul A. Wender

{"title":"Discrete Immolative Guanidinium Transporters deliver mRNA to specific organs and red blood cells","authors":"Zhijian Li, Aloysius Ee, Laura Amaya, Jennifer L. Hamad, Pavan K. Yadav, Sean K. Wang, Howard Y. Chang, Paul A. Wender","doi":"10.1038/s41467-025-62200-3","DOIUrl":"https://doi.org/10.1038/s41467-025-62200-3","url":null,"abstract":"RNA medicine is an emerging groundbreaking technology for the prevention and treatment of disease. However, tools to deliver messenger RNA (mRNA) and other polyanions (circRNA, saRNA, pDNA, CRISPR-Cas, reprogramming factors) are required to advance current RNA therapies and address next generation challenges. Existing delivery systems often suffer from laborious syntheses, limited organ selectivity, formulation complexity, and undesired inflammatory responses. Here, we report novel mRNA delivery systems termed Discrete Immolative Guanidinium Transporters (DIGITs), which are synthesized convergently in as few as 4 steps. Unlike most cationic (ammonium) delivery systems, DIGITs are based on cationic guanidinium moieties, which complex mRNA at acidic pH and undergo irreversible neutralization at physiological pH to enable efficient RNA release. Systematic evaluation of structural variations and formulations have led to DIGIT/mRNA complexes that selectively target lung, spleen, and immature red blood cells in peripheral blood in female mice model. DIGIT/mRNA delivery systems show minimal toxicity based on cell viability and biochemical assays, supporting their future utility in biomedical applications.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Read my LIPSS: organic lasers on micromachined resonators 请阅读我的LIPSS：微机械谐振器上的有机激光器

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-08-01 DOI: 10.1038/s41467-025-62502-6

Tiange Dong, Tobias Antrack, Frithjof Pietsch, Jakob Lindenthal, Markus Löffler, Bernd Rellinghaus, Johannes Benduhn, Markas Sudzius, Karl Leo

{"title":"Read my LIPSS: organic lasers on micromachined resonators","authors":"Tiange Dong, Tobias Antrack, Frithjof Pietsch, Jakob Lindenthal, Markus Löffler, Bernd Rellinghaus, Johannes Benduhn, Markas Sudzius, Karl Leo","doi":"10.1038/s41467-025-62502-6","DOIUrl":"https://doi.org/10.1038/s41467-025-62502-6","url":null,"abstract":"Thin-film lasers based on organic semiconductors offer significant potential for miniaturized sensing and optical memory. We present a new method for creating first-order distributed feedback (DFB) Bragg gratings using laser-induced periodic surface structures (LIPSS) as the optical resonator. These subwavelength structures, fabricated via femtosecond laser micromachining, exhibit stable periodicities and provide sufficient feedback for lasing in an Alq3:DCM film. The laser emission wavelength can be widely tuned by varying the LIPSS periodicity defined by the pulse spacing of the structuring laser. While lasing is limited by LIPSS imperfections, we demonstrate that individual LIPSS gratings optically couple into a coherent macroscopic supermode. This coupling dramatically increases lasing efficiency and reduces thresholds by two orders of magnitude compared to a single LIPSS element. This straightforward fabrication enables solid-state organic DFB lasers as integrated, on-chip coherent light sources, eliminating complex external coupling into photonic circuits.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"68 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coastal aquifers key contributors to ocean chemistry through solute fluxes 沿海含水层通过溶质通量对海洋化学起关键作用

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-08-01 DOI: 10.1038/s41467-025-62411-8

Yael Kiro

引用次数: 0

PAL-AI reveals genetic determinants that control poly(A)-tail length during oocyte maturation, with relevance to human fertility PAL-AI揭示了卵母细胞成熟过程中控制多(A)尾长度的遗传决定因素，与人类生育能力有关

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-08-01 DOI: 10.1038/s41467-025-62171-5

Kehui Xiang, David P. Bartel

引用次数: 0

A multicellular self-organized probiotic platform for oral delivery enhances intestinal colonization 多细胞自组织的口服益生菌平台增强肠道定植

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-08-01 DOI: 10.1038/s41467-025-62349-x

Hua Liu, Zhijie Chen, Qiaowen Lin, Yi Chen, Liwen Hong, Jie Zhong, Zhengwei Cai, Zhengting Wang, Wenguo Cui

{"title":"A multicellular self-organized probiotic platform for oral delivery enhances intestinal colonization","authors":"Hua Liu, Zhijie Chen, Qiaowen Lin, Yi Chen, Liwen Hong, Jie Zhong, Zhengwei Cai, Zhengting Wang, Wenguo Cui","doi":"10.1038/s41467-025-62349-x","DOIUrl":"https://doi.org/10.1038/s41467-025-62349-x","url":null,"abstract":"Stable gut colonization of probiotics is essential for sustained therapeutic effects, however traditional oral probiotic supplements often fail to adapt to the gut environment. Here, based on the observation that multicellular microcolonies instead of planktonic bacteria display a more advantageous gene pattern for colonization, we design a system encapsulating multicellular self-organized probiotic microcolonies, termed Express Microcolony Service (EMS), for efficient oral delivery and enhanced gut colonization of probiotics. Utilizing the stress-relaxing and acid-resistant property of the covalent-ionic crosslinking alginate hydrogel microsphere, the micro-cargo provides tunable nutrient supply and extracellular matrix support to facilitate microcolony self-organization. Notably, we show that the variable spatial constraints of the stress-relaxing hydrogel could modulate the viability and colonization potential of microcolonies. In vitro, bacteria microcolonies in EMS show remarkable resistance to gastric acid, bile salts, and antibiotics, compared with planktonic probiotics. In vivo, the EMS strategy exhibits 89- and 52-fold higher colonization rate in the cecum and colon of mice, compared to conventional oral probiotics. The multicellular self-organized EMS system offers an innovative, efficient and clinically transformable alternative for probiotic therapy.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"151 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung structural cells are altered by infeluenza virus leading to rapid immune protection following re-challenge 肺结构细胞被流感病毒改变，导致在再次感染后迅速产生免疫保护

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-08-01 DOI: 10.1038/s41467-025-62364-y

Julie C. Worrell, Kerrie E. Hargrave, George E. Finney, Chris Hansell, John Cole, Jagtar Singh Nijjar, Fraser Morton, Marieke Pingen, Tom Purnell, Kathleen Mitchelson, Euan Brennan, Clíodhna M. Daly, Jay Allan, Georgios Ilia, Vanessa Herder, Claire Kennedy Dietrich, Yoana Doncheva, Nigel B. Jamieson, Massimo Palmarini, Megan K. L. MacLeod

{"title":"Lung structural cells are altered by infeluenza virus leading to rapid immune protection following re-challenge","authors":"Julie C. Worrell, Kerrie E. Hargrave, George E. Finney, Chris Hansell, John Cole, Jagtar Singh Nijjar, Fraser Morton, Marieke Pingen, Tom Purnell, Kathleen Mitchelson, Euan Brennan, Clíodhna M. Daly, Jay Allan, Georgios Ilia, Vanessa Herder, Claire Kennedy Dietrich, Yoana Doncheva, Nigel B. Jamieson, Massimo Palmarini, Megan K. L. MacLeod","doi":"10.1038/s41467-025-62364-y","DOIUrl":"https://doi.org/10.1038/s41467-025-62364-y","url":null,"abstract":"Lung structural cells form barriers against pathogens and trigger immune responses following infections. This leads to the recruitment of innate and adaptive immune cells some of which remain within the lung and contribute to enhanced pathogen control following subsequent infections. There is growing evidence that structural cells also display long-term changes following infection. Here we investigate long-term changes to mouse lung epithelial cells, fibroblasts, and endothelial cells following influenza virus infection finding that all three cell types maintain an imprint of the infection, particularly in genes linked to communication with T cells. MHCI and MHCII proteins continue to be expressed at higher levels in both differentiated epithelial cells and progenitor populations and several differentially expressed genes are downstream of the transcription factor, SpiB, a known orchestrator of antigen presentation. Lung epithelial cells from influenza-infected mice display functional changes, more rapidly controlling influenza virus than cells from naïve animals. This rapid anti-viral response and increased expression of molecules required to communicate with T cells demonstrates sustained and enhanced functions following infection. These data suggest lung structural cells display characteristics of immune memory which could affect outcomes that are protective in the context of infection or pathogenic in chronic inflammatory disorders.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"26 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial 通过姑息性照射和ATR抑制肿瘤控制和免疫激活，PATRIOT Part C: Ib期试验

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-08-01 DOI: 10.1038/s41467-025-62249-0

Magnus T. Dillon, Emmanuel C. Patin, Kabir Mohammed, Jeane Guevara, Simon A. Smith, Emma Dean, Heba Soliman, Pablo Nenclares, Motoko Ryugenji, Davina Northcote, Neel Shah, Lorna Grove, Christopher J. Lord, Stephen Pettit, Matt Tall, Karen E. Swales, Udai Banerji, Alan A. Melcher, Mark Saunders, Martin D. Forster, Kevin J. Harrington

{"title":"Tumor control and immune activation through palliative irradiation and ATR inhibition, PATRIOT Part C: a phase Ib trial","authors":"Magnus T. Dillon, Emmanuel C. Patin, Kabir Mohammed, Jeane Guevara, Simon A. Smith, Emma Dean, Heba Soliman, Pablo Nenclares, Motoko Ryugenji, Davina Northcote, Neel Shah, Lorna Grove, Christopher J. Lord, Stephen Pettit, Matt Tall, Karen E. Swales, Udai Banerji, Alan A. Melcher, Mark Saunders, Martin D. Forster, Kevin J. Harrington","doi":"10.1038/s41467-025-62249-0","DOIUrl":"https://doi.org/10.1038/s41467-025-62249-0","url":null,"abstract":"Ataxia telangiectasia and Rad3-related kinase (ATR) is a rational radiosensitization target. In this study, we explore the combination of the ATR inhibitor, ceralasertib, and palliative radiotherapy, with primary endpoint the identification of maximum tolerated dose, and secondary endpoints the determination of adverse event causality, pharmacokinetics (PK) and anti-tumor activity. Twenty-seven patients were dosed in escalating dose cohorts from 20 to 80 mg twice daily (BD) with concomitant radiation, 20 Gy in 10 fractions or 30 Gy in 15 fractions. Patients were assessed for acute and late toxicities and response after therapy. A non-tolerated dose was not reached. Maximum administered dose was 80 mg BD ceralasertib over 3 weeks with 30 Gy in 15 fractions, at which 1/6 evaluable patients had dose-limiting toxicities (radiation dermatitis and mucositis). PK was comparable to monotherapy. Of 23 efficacy-evaluable participants, 2 (9%) had complete response (CR), 6 (26%) partial response (PR), 13 (57%) stable disease (SD) and 2 (9%) progressive disease (PD) as best response in irradiated tumors. Response was not clearly linked to genomic aberrations. Increased T and natural killer cell activation as observed in peripheral blood as treatment progressed.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Explainable multimodal deep learning for predicting thyroid cancer lateral lymph node metastasis using ultrasound imaging 可解释的多模态深度学习用于超声成像预测甲状腺癌外侧淋巴结转移

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-08-01 DOI: 10.1038/s41467-025-62042-z

Pengcheng Shen, Zheyu Yang, Jingjing Sun, Yun Wang, Cheng Qiu, Yirou Wang, Yongyong Ren, Sheng Liu, Wei Cai, Hui Lu, Siqiong Yao

{"title":"Explainable multimodal deep learning for predicting thyroid cancer lateral lymph node metastasis using ultrasound imaging","authors":"Pengcheng Shen, Zheyu Yang, Jingjing Sun, Yun Wang, Cheng Qiu, Yirou Wang, Yongyong Ren, Sheng Liu, Wei Cai, Hui Lu, Siqiong Yao","doi":"10.1038/s41467-025-62042-z","DOIUrl":"https://doi.org/10.1038/s41467-025-62042-z","url":null,"abstract":"Preoperative prediction of lateral lymph node metastasis is clinically crucial for guiding surgical strategy and prognosis assessment, yet precise prediction methods are lacking. We therefore develop Lateral Lymph Node Metastasis Network (LLNM-Net), a bidirectional-attention deep-learning model that fuses multimodal data (preoperative ultrasound images, radiology reports, pathological findings, and demographics) from 29,615 patients and 9836 surgical cases across seven centers. Integrating nodule morphology and position with clinical text, LLNM-Net achieves an Area Under the Curve (AUC) of 0.944 and 84.7% accuracy in multicenter testing, outperforming human experts (64.3% accuracy) and surpassing previous models by 7.4%. Here we show tumors within 0.25 cm of the thyroid capsule carry >72% metastasis risk, with middle and upper lobes as high-risk regions. Leveraging location, shape, echogenicity, margins, demographics, and clinician inputs, LLNM-Net further attains an AUC of 0.983 for identifying high-risk patients. The model is thus a promising for tool for preoperative screening and risk stratification.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"31 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serological evidence of clade Ib Mpox transmission by sex workers and within household in South Kivu, DRC 刚果民主共和国南基伍省性工作者和家庭内传播b支Mpox的血清学证据

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-08-01 DOI: 10.1038/s41467-025-62064-7

Leandre Murhula Masirika, Luca M. Zaeck, Pacifique Ndishimye, Jean Claude Udahemuka, Saria Otani, Frank M. Aarestrup, Leonard Schuele, Babs E. Verstrepen, Scott Jones, Ashley Otter, Corine H. GeurtsvanKessel, Jean Pierre Musabyimana, Justin Bengehya Mbiribindi, Jules Minega Ndoli, Bas B. Oude Munnink, Freddy Siangoli Belesi, Marion P. G. Koopmans, Rory D. de Vries

{"title":"Serological evidence of clade Ib Mpox transmission by sex workers and within household in South Kivu, DRC","authors":"Leandre Murhula Masirika, Luca M. Zaeck, Pacifique Ndishimye, Jean Claude Udahemuka, Saria Otani, Frank M. Aarestrup, Leonard Schuele, Babs E. Verstrepen, Scott Jones, Ashley Otter, Corine H. GeurtsvanKessel, Jean Pierre Musabyimana, Justin Bengehya Mbiribindi, Jules Minega Ndoli, Bas B. Oude Munnink, Freddy Siangoli Belesi, Marion P. G. Koopmans, Rory D. de Vries","doi":"10.1038/s41467-025-62064-7","DOIUrl":"https://doi.org/10.1038/s41467-025-62064-7","url":null,"abstract":"Understanding secondary attack rates is a key knowledge gap in the ongoing clade Ib mpox virus (MPXV) outbreak in the Democratic Republic of the Congo. Here, we report the first cross-sectional serological study to investigate local MPXV clade Ib transmission in South Kivu, DRC. Seropositivity was defined as a detectable titer in a cell lysate-based screening ELISA and confirmation by virus neutralization test. Sera were collected in November and December 2023 (n = 120), and in May 2024 (n = 48) from professional sex workers (PSW) and visitors of 25 bars with reports of mpox cases. We detected serological evidence for MPXV infection in 18% and 17% of these sera, respectively, indicating that PSW played an important role in MPXV clade Ib transmission in this region. Additionally, sera from 108 direct contacts of mpox cases from 34 households were collected between September 2023 and May 2024. Serological evidence for MPXV infection was found in at least one serum sample in 50% of households, including in nine households with seropositive minors, providing evidence for close-contact household transmission. Serological studies are needed to comprehend the extent and severity of the ongoing MPXV outbreak, and may be used to guide targeted vaccination strategies, particularly for high-risk groups.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"723 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoscale cuticle mass density variations influenced by pigmentation in butterfly wing scales 蝴蝶翅膀鳞片色素沉着对纳米尺度角质层质量密度的影响

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-08-01 DOI: 10.1038/s41467-025-62010-7

Deepan Balakrishnan, Anupama Prakash, Benedikt J. Daurer, Cédric Finet, Ying Chen Lim, Zhou Shen, Pierre Thibault, Antónia Monteiro, N. Duane Loh

{"title":"Nanoscale cuticle mass density variations influenced by pigmentation in butterfly wing scales","authors":"Deepan Balakrishnan, Anupama Prakash, Benedikt J. Daurer, Cédric Finet, Ying Chen Lim, Zhou Shen, Pierre Thibault, Antónia Monteiro, N. Duane Loh","doi":"10.1038/s41467-025-62010-7","DOIUrl":"https://doi.org/10.1038/s41467-025-62010-7","url":null,"abstract":"How pigment distribution influences the cuticle density within a microscopic butterfly wing scale, and how both impact each scale’s final reflected color, remains unknown. We use ptychographic X-ray computed tomography to quantitatively determine, at nanoscale resolutions, the three-dimensional mass density of scales with pigmentation differences. By comparing cuticle densities between two pairs of scales with pigmentation differences, we determine that the density of the lower lamina is inversely correlated with pigmentation. In the upper lamina structure of Junonia orithya and Bicyclus anynana, low pigment levels also correlate with sheet-like chitin structures as opposed to rod-like structures. Within each scale, we determine that the lower lamina in all scales has the highest density, and distinct layers within the lower lamina help explain reflected color. We hypothesize that pigments, in addition to absorbing specific wavelengths, can affect cuticle polymerization, density, and refractive index, thereby impacting reflected wavelengths that produce colors.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"147 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0