Nature Communications最新文献

{"title":"Vulnerability of power distribution networks to local temperature changes induced by global climate change","authors":"Kishan Prudhvi Guddanti, Lin Chen, Yang Weng, Yang Yu","doi":"10.1038/s41467-025-59749-4","DOIUrl":"https://doi.org/10.1038/s41467-025-59749-4","url":null,"abstract":"<p>Global climate change (GCC) triggers a chain effect, converting temperature pattern changes into variations in blackout risk for power distribution grids (DGs). This occurs through GCC’s impacts on electricity supply, demand, and infrastructure, which shift the DG’s safe-operation boundary and power flow. This study presents a model integration framework to assess the associated blackout risk, showing that GCC raises blackout risks during peak hours by 4–6%, depending on Gross Domestic Product growth. Kirchhoff’s laws amplify these effects, creating nonlinear risk trajectories. Analysis of the chain effect suggests adaptation strategies, including reshaping grid topology and pairing temperature-sensitive users with robust buses. Index-based analysis reveals that over 20% of the U.S. requires at least a 10% DG capacity increase before 2050, with six states exceeding 20%. Europe faces a more moderate impact. These findings highlight the need for policymakers to prioritize peak-load management and address nonlinear risks across regions.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"8 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wastewater surveillance of SARS-CoV-2 from aircraft to citywide monitoring","authors":"Mariel Perez-Zabaleta, Carlo Berg, Neus Latorre-Margalef, Isaac Owusu-Agyeman, Ayda Kiyar, Helene Botnen, Caroline Schönning, Luisa W. Hugerth, Zeynep Cetecioglu","doi":"10.1038/s41467-025-60490-1","DOIUrl":"https://doi.org/10.1038/s41467-025-60490-1","url":null,"abstract":"<p>Wastewater monitoring is highly efficient in SARS-CoV-2 surveillance for tracking virus spread through travel, surpassing traditional airport passenger testing. This study explored the links between SARS-CoV-2 contents and variants from aircraft to city, assessing the impact of detected variants from international travellers versus the local population. A total of 969 variants using next-generation sequencing (NGS) were examined to understand the links between—aircraft, Arlanda airport, wastewater treatment plants (WWTPs), and Stockholm city—and compared these to variants detected in Stockholm hospitals from January to May 2023. SARS-CoV-2 contents in WWTPs reflected local infection rates, requiring analysis from multiple plants for an accurate city-wide infection assessment. Variants initially detected in aircraft arriving from China did not spread widely during the study period. RT-qPCR is adequate for the detection of specific variants in wastewater, including Variants Under Monitoring. However, NGS remains a powerful method for identifying novel variants. Wastewater monitoring was more effective than clinical testing in the early detection of specific variants, with notable delays observed in clinical surveillance. Furthermore, a broad range of variants are detected in wastewater that surpasses clinical tests. This underscores the vital role of wastewater-based epidemiology in managing future outbreaks and enhancing global health security.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"8 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-powered activatable NIR-II fluorescent nanosensor for in vivo monitoring of plant stress responses","authors":"Hong Hu, Hao Yuan, Shengchun Sun, Jianxing Feng, Ning Shi, Zexiang Wang, Yan Liang, Yibin Ying, Yixian Wang","doi":"10.1038/s41467-025-60182-w","DOIUrl":"https://doi.org/10.1038/s41467-025-60182-w","url":null,"abstract":"<p>Real-time monitoring of plant stress signaling molecules is crucial for early disease diagnosis and prevention. However, existing methods are often invasive and lack sensitivity, rendering them inadequate for continuous monitoring of subtle plant stress responses. In this study, we develop a non-destructive near-infrared-II (NIR-II) fluorescent nanosensor for real-time detection of stress-related H₂O₂ signaling in living plants. This nanosensor effectively avoids interference from plant autofluorescence and specifically responds to trace amounts of endogenous H₂O₂, thereby providing a reliable means to real-time report stress information. We validate that it is a species-independent nanosensor by effectively monitoring the stress responses of different plant species. Additionally, with the aid of a machine learning model, we demonstrate that the nanosensor can accurately differentiate between four types of stress with an accuracy of more than 96.67%. Our study enhances the understanding of plant stress signaling mechanisms and offers reliable optical tools for precision agriculture.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"59 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large live biomass carbon losses from droughts in the northern temperate ecosystems during 2016-2022","authors":"Xiaojun Li, Philippe Ciais, Rasmus Fensholt, Jérome Chave, Stephen Sitch, Josep G. Canadell, Martin Brandt, Lei Fan, Xiangming Xiao, Shengli Tao, Huan Wang, Clément Albergel, Hui Yang, Frédéric Frappart, Mengjia Wang, Ana Bastos, Philippe Maisongrande, Yuanwei Qin, Zanpin Xing, Tianxiang Cui, Ling Yu, Lei He, Yi Zheng, Xiangzhuo Liu, Yuqing Liu, Aurelien De Truchis, Jean-Pierre Wigneron","doi":"10.1038/s41467-025-59999-2","DOIUrl":"https://doi.org/10.1038/s41467-025-59999-2","url":null,"abstract":"<p>Northern ecosystems (≥ 30° N) have been accumulating vegetation biomass carbon in recent decades, but increasing droughts and wildfires threaten this carbon sink. Here, we analyse annual changes in live vegetation biomass in northern ecosystems using low-frequency microwave satellite observations at 25 km spatial resolution from 2010 to 2022. We find that live biomass carbon stocks have undergone a reversal from a positive to a negative trend during the study period with 2016 marking the turning point. During 2016–2022, live biomass carbon stocks decreased at a rate of <span>({-{{mathbf{0.20}}}}_{-{{mathbf{0.26}}}}^{-{{mathbf{0.11}}}})</span> PgC yr⁻¹ across northern ecosystems, primarily in temperate biomes (<span>({-{{mathbf{0.26}}}}_{-{{mathbf{0.33}}}}^{-{{mathbf{0.17}}}})</span> PgC yr⁻¹). The annual mean gross loss of 4% of live biomass carbon in this region during 2016-2022 reflects high interannual variability, with significant losses associated with droughts and a further drop of <span>({-{{mathbf{0.60}}}}_{-{{mathbf{0.75}}}}^{-{{mathbf{0.47}}}})</span> PgC in the very dry year of 2022. Our findings highlight the vulnerability of live biomass carbon stocks to emerging climate-induced disturbances in northern ecosystems, challenging the sustainability of the current large terrestrial carbon sink in this key region for the global carbon balance.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"5 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial potential to mitigate neurotoxic methylmercury accumulation in farmlands and rice","authors":"Xin-Quan Zhou, Kang-Hua Chen, Ri-Qing Yu, Man Yang, Qin Liu, Yun-Yun Hao, Jibing Li, Hui-Wen Liu, Jiao Feng, Wenfeng Tan, Qiaoyun Huang, Baohua Gu, Yu-Rong Liu","doi":"10.1038/s41467-025-60458-1","DOIUrl":"https://doi.org/10.1038/s41467-025-60458-1","url":null,"abstract":"<p>Toxic methylmercury (CH₃Hg⁺) is produced by microbial conversion of inorganic mercury in hypoxic environments such as rice paddy soils, and can accumulate in rice grains. Although microbial demethylation has been recognized as a crucial pathway for CH₃Hg⁺ degradation, the identities of microbes and pathways accountable for CH₃Hg⁺ degradation in soil remain elusive. Here, we combine ¹³CH₃Hg⁺-DNA stable-isotope probing experiments with shotgun metagenomics to explore microbial taxa and associated biochemical processes involved in CH₃Hg⁺ degradation in paddy and upland soils. We identify <i>Pseudarthrobacter</i>, <i>Methylophilaceae</i> (MM2), and <i>Dechloromonas</i> as the most significant taxa potentially engaged in the degradation of ¹³CH₃Hg⁺ in paddy soil with high mercury contamination. We confirm that strains affiliated with two of those taxa (species <i>Dechloromonas denitrificans</i> and <i>Methylovorus menthalis</i>) can degrade CH₃Hg⁺ in pure culture assays. Metagenomic analysis further reveals that most of these candidate ¹³CH₃Hg⁺ degraders carry genes associated with the Wood-Ljungdahl pathway, dicarboxylate-hydroxybutyrate cycle, methanogenesis, and denitrification, but apparently lack the <i>merB</i> and <i>merA</i> genes involved in CH₃Hg⁺ reductive demethylation. Finally, we estimate that microbial degradation of soil CH₃Hg⁺ contributes to 0.08–0.64 fold decreases in CH₃Hg⁺ accumulation in rice grains across China (hazard quotient (HQ) decrements of 0.62–13.75%). Thus, our results provide insights into microorganisms and pathways responsible for CH₃Hg⁺ degradation in soil, with potential implications for development of bioremediation strategies.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"62 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constraints on sea-level rise during meltwater pulse 1B from the Great Barrier Reef","authors":"Jody M. Webster, Yusuke Yokoyama, Marc Humblet, Juan Carlos Braga, Tezer Esat, Stewart Fallon, Edouard Bard","doi":"10.1038/s41467-025-59858-0","DOIUrl":"https://doi.org/10.1038/s41467-025-59858-0","url":null,"abstract":"<p>The timing, rate, and magnitude of rapid sea-level rise during Meltwater Pulse 1B (MWP-1B, ~11.45–11.1 ka) remain controversial. Robust constraints on past MWPs are crucial to future predictions of global ice sheet instability. Using 154 new and existing U/Th and calibrated ¹⁴C-AMS dates from coral, algae, and microbialites recovered during Integrated Ocean Drilling Program Expedition 325, this study reconstructs reef development and relative sea-level (RSL) rise on the Great Barrier Reef (GBR). We identify 107 in situ RSL index points while refining estimates of vertical accretion and paleowater depth. Results show RSL rise during MWP-1B did not exceed 10.2–7.7 m or rates of 30–23 mm/yr, and was likely less. The GBR did not drown, indicating resilience to MWP-1B. These findings are more consistent with Tahiti and other Pacific records and do not support the Barbados record of MWP-1B as an abrupt step in global sea level, with a magnitude &gt; 11 m.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"7 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Divergent combinations of enhancers encode spatial gene expression","authors":"Danni Hong, Muya Shu, Jiamao Liu, Lifang Liu, Hao Cheng, Ming Zhu, Yi Du, Bo Xu, Di Hu, Zhiyong Liu, Yannan Zhao, Jianwu Dai, Falong Lu, Jialiang Huang","doi":"10.1038/s41467-025-60482-1","DOIUrl":"https://doi.org/10.1038/s41467-025-60482-1","url":null,"abstract":"<p>Spatial transcriptomics and epigenomics have enabled mapping gene regulation in the tissue context. However, it remains poorly understood how spatial gene expression patterns are orchestrated by enhancers. Here we build eSpatial, a computational framework that deciphers spatially resolved enhancer regulation of gene expression by integrating spatial profiles of gene expression and chromatin accessibility. Applying eSpatial to diverse spatial datasets, including mouse embryo and brain, as well as human melanoma and breast cancer, we reveal a “spatial enhancer code”, in which divergent combinations of enhancers regulate the same gene in spatially segregated domains. We validate the spatial enhancer code using public spatial datasets such as VISTA, Allen in situ hybridization (ISH), and H3K27ac MERFISH. Moreover, we conduct transgenic reporter assays and in vivo CRISPR/Cas9-mediated perturbation experiments to confirm the <i>Atoh1</i> spatial enhancer code in determining <i>Atoh1</i> spatial expression in mouse embryonic spinal cord and brain. Our study establishes the spatial enhancer code concept, revealing how combinations of enhancers dynamically shape gene expression across diverse biological contexts, providing insights into tissue-specific regulatory mechanisms and tumor heterogeneity.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"37 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of deep-learning-based approaches to improve polygenic scores","authors":"Martin Kelemen, Yu Xu, Tao Jiang, Jing Hua Zhao, Carl A. Anderson, Chris Wallace, Adam Butterworth, Michael Inouye","doi":"10.1038/s41467-025-60056-1","DOIUrl":"https://doi.org/10.1038/s41467-025-60056-1","url":null,"abstract":"<p>Polygenic scores, which estimate an individual’s genetic propensity for a disease or trait, have the potential to become part of genomic healthcare. Neural-network based deep-learning has emerged as a method of intense interest to model complex, nonlinear phenomena, which may be adapted to exploit gene-gene and gene-environment interactions to potentially improve polygenic scores. We fit neural-network models to both simulated and 28 real traits in the UK Biobank. To infer the amount of nonlinearity present in a phenotype, we also present a framework using neural-networks, which controls for the potential confounding effect of linkage disequilibrium. Although we found evidence for small amounts of nonlinear effects, neural-network models were outperformed by linear regression models for both genetic-only and genetic+environmental input scenarios. In this work, we find that the usefulness of neural-networks for generating polygenic scores may currently be limited and confounded by joint tagging effects due to linkage disequilibrium.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"17 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ELMO2 is an essential regulator of carotid artery development","authors":"Athira Suresh, Kai Kruse, Hendrik Arf, Rodrigo Diéguez-Hurtado, Ralf H. Adams","doi":"10.1038/s41467-025-60105-9","DOIUrl":"https://doi.org/10.1038/s41467-025-60105-9","url":null,"abstract":"<p>Engulfment and cell motility 2 (ELMO2) is a cytoskeletal adaptor protein necessary for cell migration and apoptotic cell removal. Loss-of-function mutations in <i>ELMO2</i> cause intraosseous vascular malformation (VMOS), a human disease involving progressive expansion of craniofacial bones in combination with anomalies in blood vessels that emerge from the external carotid artery, as well as aneurysms in the internal carotid artery. Here we show that global inactivation of <i>Elmo2</i> in mice leads to midgestation embryonic lethality due to dilation of the 3^rd pharyngeal arch arteries and aneurysm formation in the common carotids. These vascular malformations are associated to defects in vascular smooth muscle cell organization and are phenocopied upon neural crest-specific deletion. In vitro experiments further confirm that ELMO2 regulates vascular smooth muscle cell adhesion, spreading and contractility through Rac1 activation and modulation of actin dynamics. Our findings provide new insights into the biological function of ELMO2 with relevant implications for understanding VMOS pathogenesis and raise the possibility of vessel-targeted diagnostic and treatment strategies.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"45 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective targeting of genome amplifications and repeat elements by CRISPR-Cas9 nickases to promote cancer cell death","authors":"Matthew B. Hanlon, Jason M. Shohet, Scot A. Wolfe","doi":"10.1038/s41467-025-60160-2","DOIUrl":"https://doi.org/10.1038/s41467-025-60160-2","url":null,"abstract":"<p>Focal gene amplification serves as an oncogenic driver during tumorigenesis and is a hallmark of many forms of cancer. Oncogene amplifications promote genomic instability, which is integral to cancer cell survival and evolution. However, focal gene amplification potentially affords an opportunity for therapeutic exploitation. As a proof-of-concept, we leverage CRISPR-Cas9 nickase to selectively promote cancer cell death in <i>MYCN</i>-amplified neuroblastoma in a gene amplification-dependent manner. Our analysis demonstrates that CRISPR-Cas9 nickase can generate a lethal number of highly toxic, replication-dependent double-strand breaks in cells harboring amplified loci. Furthermore, we demonstrate that Cas9 nickase—mediated toxicity can be modulated in combination with small molecule inhibitors targeting key regulators of the DNA-damage response or cell death pathways. Importantly, our findings in <i>MYCN</i>-amplified neuroblastoma translate to other cancer types with distinct oncogene amplifications.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"42 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}