Nature Communications最新文献_第8页

Stabilized D₂R G protein-coupled receptor oligomers identify multi-state β-arrestin complexes. 稳定的d2rg蛋白偶联受体低聚物鉴定多态β-阻滞蛋白复合物。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2025-10-02 DOI: 10.1038/s41467-025-64008-7

Katie L Sharrocks, Francesca Fanelli, Yewei Liu, Annabelle J Milner, Wu Yining, Bernadette Byrne, Aylin C Hanyaloglu

{"title":"Stabilized D2R G protein-coupled receptor oligomers identify multi-state β-arrestin complexes.","authors":"Katie L Sharrocks, Francesca Fanelli, Yewei Liu, Annabelle J Milner, Wu Yining, Bernadette Byrne, Aylin C Hanyaloglu","doi":"10.1038/s41467-025-64008-7","DOIUrl":"https://doi.org/10.1038/s41467-025-64008-7","url":null,"abstract":"The G protein-coupled receptor (GPCR) superfamily directs central roles in many physiological and pathophysiological processes via diverse and complex mechanisms. GPCRs can exhibit signal pleiotropy via formation of di/oligomers both with themselves and other GPCRs. A deeper understanding of the molecular basis and functional role of oligomerization would facilitate rational design of activity-selective ligands. A structural model of the D2 dopamine receptor (D2R) homomer identified distinct combinations of substitutions likely to stabilize protomer interactions. Molecular modelling of β-arrestin-2 (βarr2) bound to predicted dimer models suggests a 2:2 receptor: βarr2 stoichiometry, with the dimer favouring βarr2 over Gαi coupling. A combination of biochemical, biophysical and super-resolution, single molecule imaging approaches demonstrated that the D2R mutant homomers exhibited greater stability. The mutant D2R homomers also exhibited bias towards recruitment of the GPCR adaptor protein βarr2 with either faster or ligand-independent βarr2 recruitment, increased internalization and reprogrammed regulation of ERK signaling. Through GPCR dimer-stabilization, we propose that D2R di/oligomerization has a role in βarr2-biased signaling.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8768"},"PeriodicalIF":15.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile cascade-anchored synthesis of ultrahigh metal loading single-atom for significantly improved Fenton-like catalysis. 易级联锚定合成超高金属负载单原子，显著改善了类芬顿催化。

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-10-02 DOI: 10.1038/s41467-025-63858-5

Shuaishuai Li,Wei Wang,Huizhong Wu,Xuechun Wang,Shihu Ding,Jingyang Liu,Xiuwu Zhang,Jiangli Sun,Chunhong Fu,Minghua Zhou

{"title":"Facile cascade-anchored synthesis of ultrahigh metal loading single-atom for significantly improved Fenton-like catalysis.","authors":"Shuaishuai Li,Wei Wang,Huizhong Wu,Xuechun Wang,Shihu Ding,Jingyang Liu,Xiuwu Zhang,Jiangli Sun,Chunhong Fu,Minghua Zhou","doi":"10.1038/s41467-025-63858-5","DOIUrl":"https://doi.org/10.1038/s41467-025-63858-5","url":null,"abstract":"It is crucial to break the low metal-loading limitation and reveal the intersite synergy-governed catalytic behavior of single-atom catalysts (SACs). Here, a universal synthesis strategy achieves record loadings of transition metals (Fe 41.31 wt%, Mn 35.13 wt%), rare-earth metals (La 28.62 wt%), and noble metals (Ag 27.04 wt%). The strong oxalic acid-metal chelation and concurrent entangled polymer networks enable high-loading SACs. High-density single atoms induce site-intensive effects, modulating electron density and valence states to achieve peroxymonosulfate-based Fenton-like reactions with rate constants 1-2 orders of magnitude higher than conventional SACs. Elevated metal loading boosts Fenton-like potential jumps, facilitates electron transfer, and reduces the rate-limiting energy barrier in 1O2 production. This material is also proven effective in real wastewater treatment, combining high decontamination efficiency with operational stability. It is anticipated that the cascade-anchoring synthesis strategy will take SACs a step closer to practical applications.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"27 1","pages":"8796"},"PeriodicalIF":16.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Trait mediation explains decadal distributional shifts for a wide range of insect taxa. 作者更正：性状中介解释了广泛昆虫分类群的年代际分布变化。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2025-10-01 DOI: 10.1038/s41467-025-64720-4

Yoann Bourhis, Alice E Milne, Chris R Shortall, Björn Beckman, Dan Blumgart, Rowan Edwards, Luke C Evans, Chris W Foster, Richard Fox, Marc S Botham, Clare Rowland, Stuart Roberts, Martin C D Speight, Chris Hassall, William E Kunin, James R Bell

引用次数: 0

Antarctic seep emergence and discovery in the shallow coastal environment. 南极浅海环境中渗漏的出现与发现。

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-10-01 DOI: 10.1038/s41467-025-63404-3

Sarah Seabrook,Cliff S Law,Andrew R Thurber,Yoann Ladroit,Vonda Cummings,Leigh Tait,Alicia Maurice,Ian Hawes

{"title":"Antarctic seep emergence and discovery in the shallow coastal environment.","authors":"Sarah Seabrook,Cliff S Law,Andrew R Thurber,Yoann Ladroit,Vonda Cummings,Leigh Tait,Alicia Maurice,Ian Hawes","doi":"10.1038/s41467-025-63404-3","DOIUrl":"https://doi.org/10.1038/s41467-025-63404-3","url":null,"abstract":"We report striking discoveries of numerous seafloor seeps of climate-reactive fluid and gases in the coastal Ross Sea, indicating this process may be a common phenomenon in the region. We establish the recent emergence of many of these seep features, based on their discovery in areas routinely surveyed for decades with no previous seep presence. Additionally, we highlight impacts to the local benthic ecosystem correlated to seep presence and discuss potential broader implications. With these discoveries, our understanding of Antarctic seafloor seeps shifts from them being rare phenomenon to seemingly widespread, and an important question is raised about the driver of seep emergence in the region. While the origin and underlying mechanisms of these emerging seep systems remains unknown, similar processes in the paleo-record and the Arctic have been attributed to climate-driven cryospheric change. Such a mechanism may be widespread around the Antarctic Continent, with concerning positive feedbacks that are currently undetermined. Future, internationally coordinated research is required to uncover the causative mechanisms of the seep emergence reported here and reveal potential sensitivities to contemporary climate change and implications for surrounding ecosystems.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"78 1","pages":"8740"},"PeriodicalIF":16.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unifying machine learning and interpolation theory via interpolating neural networks. 通过插值神经网络统一机器学习和插值理论。

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-10-01 DOI: 10.1038/s41467-025-63790-8

Chanwook Park,Sourav Saha,Jiachen Guo,Hantao Zhang,Xiaoyu Xie,Miguel A Bessa,Dong Qian,Wei Chen,Gregory J Wanger,Jian Cao,Thomas J R Hughes,Wing Kam Liu

{"title":"Unifying machine learning and interpolation theory via interpolating neural networks.","authors":"Chanwook Park,Sourav Saha,Jiachen Guo,Hantao Zhang,Xiaoyu Xie,Miguel A Bessa,Dong Qian,Wei Chen,Gregory J Wanger,Jian Cao,Thomas J R Hughes,Wing Kam Liu","doi":"10.1038/s41467-025-63790-8","DOIUrl":"https://doi.org/10.1038/s41467-025-63790-8","url":null,"abstract":"Computational science and engineering are shifting toward data-centric, optimization-based, and self-correcting solvers with artificial intelligence. This transition faces challenges such as low accuracy with sparse data, poor scalability, and high computational cost in complex system design. This work introduces Interpolating Neural Network (INN)-a network architecture blending interpolation theory and tensor decomposition. INN significantly reduces computational effort and memory requirements while maintaining high accuracy. Thus, it outperforms traditional partial differential equation (PDE) solvers, machine learning (ML) models, and physics-informed neural networks (PINNs). It also efficiently handles sparse data and enables dynamic updates of nonlinear activation. Demonstrated in metal additive manufacturing, INN rapidly constructs an accurate surrogate model of Laser Powder Bed Fusion (L-PBF) heat transfer simulation. It achieves sub-10-micrometer resolution for a 10 mm path in under 15 minutes on a single GPU, which is 5-8 orders of magnitude faster than competing ML models. This offers a new perspective for addressing challenges in computational science and engineering.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"76 1","pages":"8753"},"PeriodicalIF":16.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The slit diaphragm in Drosophila exhibits a bilayered, fishnet architecture. 果蝇的狭缝隔膜呈双层鱼网状结构。

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-10-01 DOI: 10.1038/s41467-025-64347-5

Deborah Moser,Konrad Lang,Alexandra N Birtasu,Florian Grahammer,Martin Helmstädter,Margot P Scheffer,Tobias Hermle,Achilleas S Frangakis

引用次数: 0

H₂O₂-mediated oxidation of PHOSPHATE STARVATION RESPONSE2 promotes adaptation to low phosphate in rice. h2o2介导的磷酸盐饥饿反应2的氧化促进了水稻对低磷酸盐的适应。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2025-10-01 DOI: 10.1038/s41467-025-63841-0

Funing Meng, Dan Xiang, Ziqi Bu, Rongbin Lin, Xinyang Sun, Jiming Xu, Yunrong Wu, Yu Liu, Zhongchang Wu, Xiaorong Mo, Javier Paz-Ares, Chuanzao Mao

{"title":"H2O2-mediated oxidation of PHOSPHATE STARVATION RESPONSE2 promotes adaptation to low phosphate in rice.","authors":"Funing Meng, Dan Xiang, Ziqi Bu, Rongbin Lin, Xinyang Sun, Jiming Xu, Yunrong Wu, Yu Liu, Zhongchang Wu, Xiaorong Mo, Javier Paz-Ares, Chuanzao Mao","doi":"10.1038/s41467-025-63841-0","DOIUrl":"https://doi.org/10.1038/s41467-025-63841-0","url":null,"abstract":"Phosphorus (P) is an essential macro-nutrient for plant growth and development. It is preferentially taken as inorganic phosphate (Pi). Plants have evolved elaborate mechanisms to adapt to low Pi (LP) stress through activating Pi-starvation responses. H2O2 is an important signal molecule involved in plant adaptation to diverse environmental stresses. However, whether H2O2 plays a role in Pi-starvation responses remains unknown. Here, we reveal that H2O2 produced by the respiratory burst oxidase homologs OsRBOH-D/H facilitates phosphate uptake and utilization under LP conditions in rice. Mechanistically LP-induced H2O2 promotes the oxidization of the key phosphate signaling transcription factor PHOSPHATE STARVATION RESPONSE2 (OsPHR2) at its Cys377 residue to trigger its oligomerization, sequence-specific DNA binding ability, and nuclear translocation, thereby activating Pi-starvation responses to adapt to LP conditions. Additionally, our molecular and biochemical data revealed that OsRBOH-D is a direct target gene of OsPHR2. Thus, OsPHR2 and OsRBOH-D form a positive feedback regulatory loop in which H2O2 acts as a second messenger to amplify the Pi-starvation response.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8760"},"PeriodicalIF":15.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Impacts of convection, chemistry, and forest clearing on biogenic volatile organic compounds over the Amazon. 作者更正：对流、化学和森林砍伐对亚马逊地区生物源性挥发性有机化合物的影响。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2025-10-01 DOI: 10.1038/s41467-025-64764-6

Nidhi Tripathi, Bianca E Krumm, Achim Edtbauer, Akima Ringsdorf, Nijing Wang, Matthias Kohl, Ryan Vella, Luiz A T Machado, Andrea Pozzer, Jos Lelieveld, Jonathan Williams

引用次数: 0

Decadal change of seismic structure in the Earth's lowermost mantle. 地球最下层地幔地震结构的年代际变化。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2025-10-01 DOI: 10.1038/s41467-025-63814-3

Xin Zhang, Lianxing Wen

引用次数: 0

In-situ boundary bridging unlocks multi-grain-domain carrier diffusion in polycrystalline metal halide perovskites. 原位边界桥接解锁多晶金属卤化物钙钛矿中的多晶域载流子扩散。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2025-10-01 DOI: 10.1038/s41467-025-63777-5

Minhuan Wang, Yanfeng Yin, Pengfei Wang, Wenzhe Shang, Yaling Han, Jing Gao, Kangshuo Hui, Tao Feng, Ummugulsum Gunes, Tristan Georges, Lyndon Emsley, Peng Xu, Jiming Bian, Jing Cao, Zhehan Ying, Rui Cai, Jingyi Xiao, Shengye Jin, Xiaoqing Jiang, Shaik M Zakeeruddin, Wenming Tian, Likai Zheng, Yantao Shi, Michael Grätzel

{"title":"In-situ boundary bridging unlocks multi-grain-domain carrier diffusion in polycrystalline metal halide perovskites.","authors":"Minhuan Wang, Yanfeng Yin, Pengfei Wang, Wenzhe Shang, Yaling Han, Jing Gao, Kangshuo Hui, Tao Feng, Ummugulsum Gunes, Tristan Georges, Lyndon Emsley, Peng Xu, Jiming Bian, Jing Cao, Zhehan Ying, Rui Cai, Jingyi Xiao, Shengye Jin, Xiaoqing Jiang, Shaik M Zakeeruddin, Wenming Tian, Likai Zheng, Yantao Shi, Michael Grätzel","doi":"10.1038/s41467-025-63777-5","DOIUrl":"https://doi.org/10.1038/s41467-025-63777-5","url":null,"abstract":"Charge transport and extraction in polycrystalline perovskite films are often hindered by inefficient carrier transfer across grain domain boundaries (GDBs). Herein, we present a universal post-treatment strategy leveraging supramolecular crown ether-assisted slow release and precise delivery of Rb⁺ cations to GDBs, achieving in-situ GDB bridging. The solid-state nuclear magnetic resonance (NMR), transmission electron microscopic (TEM), and time-of-flight secondary ion mass spectrometry (ToF-SIMS) analyses confirm that Rb+ forms a non-perovskite phase, primarily localized at the surface and GDBs. Ultrafast time-resolved photoluminescence mapping revealed accelerated carrier diffusion across the grain boundaries for the Rb+-treated perovskite thin films which enables photo-generated charge carriers to travels over two grain domain boundaries before recombination. As a result, perovskite solar cells treated with this strategy achieved a champion efficiency of 26.02% (certified as 25.77%) and demonstrated remarkable stability, retaining 99.2% of their initial efficiency after 1300 h of continuous one-sun illumination under maximum power point tracking (ISOS-L-1I).","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8755"},"PeriodicalIF":15.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0