Nature Communications最新文献_第7页

Accurate eye tracking from dense 3D surface reconstructions using single-shot deflectometry

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-01 DOI: 10.1038/s41467-025-56801-1

Jiazhang Wang, Tianfu Wang, Bingjie Xu, Oliver Cossairt, Florian Willomitzer

{"title":"Accurate eye tracking from dense 3D surface reconstructions using single-shot deflectometry","authors":"Jiazhang Wang, Tianfu Wang, Bingjie Xu, Oliver Cossairt, Florian Willomitzer","doi":"10.1038/s41467-025-56801-1","DOIUrl":"https://doi.org/10.1038/s41467-025-56801-1","url":null,"abstract":"Eye-tracking plays a crucial role in the development of virtual reality devices, neuroscience research, and psychology. Despite its significance in numerous applications, achieving an accurate, robust, and fast eye-tracking solution remains a considerable challenge for current state-of-the-art methods. While existing reflection-based techniques (e.g., “glint tracking\") are considered to be very accurate, their performance is limited by their reliance on sparse 3D surface data acquired solely from the cornea surface. In this paper, we rethink the way how specular reflections can be used for eye tracking: We propose a method for accurate and fast evaluation of the gaze direction that exploits teachings from single-shot phase-measuring-deflectometry. In contrast to state-of-the-art reflection-based methods, our method acquires dense 3D surface information of both cornea and sclera within only one single camera frame (single-shot). For a typical measurement, we acquire >3000× more surface reflection points (\"glints”) than conventional methods. We show the feasibility of our approach with experimentally evaluated gaze errors on a realistic model eye below only 0.13°. Moreover, we demonstrate quantitative measurements on real human eyes in vivo, reaching accuracy values between only 0.46° and 0.97°.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"34 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-01 DOI: 10.1038/s41467-025-58467-1

Jie-Ying Zhu, Min Chen, Wang-Jing Mu, Hong-Yang Luo, Yang Li, Shan Li, Lin-Jing Yan, Ruo-Ying Li, Meng-Ting Yin, Xin Li, Hu-Min Chen, Liang Guo

{"title":"Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis","authors":"Jie-Ying Zhu, Min Chen, Wang-Jing Mu, Hong-Yang Luo, Yang Li, Shan Li, Lin-Jing Yan, Ruo-Ying Li, Meng-Ting Yin, Xin Li, Hu-Min Chen, Liang Guo","doi":"10.1038/s41467-025-58467-1","DOIUrl":"https://doi.org/10.1038/s41467-025-58467-1","url":null,"abstract":"Exercise combats obesity and metabolic disorders, but the underlying mechanism is incompletely understood. KLF10, a transcription factor involved in various biological processes, has an undefined role in adipose tissue and obesity. Here, we show that exercise facilitates adipocyte-derived KLF10 expression via SIRT1/FOXO1 pathway. Adipocyte-specific knockout of KLF10 blunts exercise-promoted white adipose browning, energy expenditure, fat loss, glucose tolerance in diet-induced obese male mice. Conversely, adipocyte-specific transgenic expression of KLF10 in male mice enhanced the above metabolic profits induced by exercise. Mechanistically, KLF10 interacts with FOXO1 and facilitates the recruitment of KDM4A to form a ternary complex on the promoter regions of Pnpla2 and Lipe genes to promote these key lipolytic genes expression by demethylating H3K9me3 on their promoters, which facilitates lipolysis to defend against obesity in male mice. As a downstream effector responding to exercise, adipose KLF10 could act as a potential target in the fight against obesity.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"50 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

790,000 years of millennial-scale Cape Horn Current variability and interhemispheric linkages

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-01 DOI: 10.1038/s41467-025-58458-2

Vincent Rigalleau, Frank Lamy, Nicoletta Ruggieri, Henrik Sadatzki, Helge W. Arz, Stephen Barker, Lester Lembke-Jene, Antje Wegwerth, Gregor Knorr, Igor M. Venancio, Tainã M. L. Pinho, Ralf Tiedemann, Gisela Winckler

{"title":"790,000 years of millennial-scale Cape Horn Current variability and interhemispheric linkages","authors":"Vincent Rigalleau, Frank Lamy, Nicoletta Ruggieri, Henrik Sadatzki, Helge W. Arz, Stephen Barker, Lester Lembke-Jene, Antje Wegwerth, Gregor Knorr, Igor M. Venancio, Tainã M. L. Pinho, Ralf Tiedemann, Gisela Winckler","doi":"10.1038/s41467-025-58458-2","DOIUrl":"https://doi.org/10.1038/s41467-025-58458-2","url":null,"abstract":"Millennial-scale variations in the strength and position of the Antarctic Circumpolar Current exert considerable influence on the global meridional overturning circulation and the ocean carbon cycle. The mechanistic understanding of these variations is still incomplete, partly due to the scarcity of sediment records covering multiple glacial-interglacial cycles with millennial-scale resolution. Here, we present high-resolution current strength and sea surface temperature records covering the past 790,000 years from the Cape Horn Current as part of the subantarctic Antarctic Circumpolar Current system, flowing along the Chilean margin. Both temperature and current velocity data document persistent millennial-scale climate variability throughout the last eight glacial periods with stronger current flow and warmer sea surface temperatures coinciding with Antarctic warm intervals. These Southern Hemisphere changes are linked to North Atlantic millennial-scale climate fluctuations, plausibly involving changes in the Atlantic thermohaline circulation. The variations in the Antarctic Circumpolar Current system are associated with atmospheric CO2 changes, suggesting a mechanistic link through the Southern Ocean carbon cycle.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"7 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altermagnetic ground state in distorted Kagome metal CsCr3Sb5

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-01 DOI: 10.1038/s41467-025-58446-6

Chenchao Xu, Siqi Wu, Guo-Xiang Zhi, Guanghan Cao, Jianhui Dai, Chao Cao, Xiaoqun Wang, Hai-Qing Lin

{"title":"Altermagnetic ground state in distorted Kagome metal CsCr3Sb5","authors":"Chenchao Xu, Siqi Wu, Guo-Xiang Zhi, Guanghan Cao, Jianhui Dai, Chao Cao, Xiaoqun Wang, Hai-Qing Lin","doi":"10.1038/s41467-025-58446-6","DOIUrl":"https://doi.org/10.1038/s41467-025-58446-6","url":null,"abstract":"The CsCr3Sb5 exhibits superconductivity in close proximity to a density-wave (DW) like ground state at ambient pressure1, however details of the DW is still elusive. Using first-principles density-functional calculations, we found its ground state to be a 4 × 2 altermagnetic spin-density-wave (SDW) at ambient pressure, with an averaged effective moment of ~ 1.7μB/Cr. The magnetic long range order is coupled to the lattice, generating 4a0 structural modulation. Multiple competing SDW phases are present and energetically close, suggesting strong magnetic fluctuation at finite temperature. The electronic states near Fermi level are dominated by Cr-3d orbitals, and the kagome flat bands are closer to the Fermi level than those in the AV3Sb5 family in paramagnetic state. When external pressure is applied, the energy differences between competing orders and structural modulations are suppressed. Yet, the magnetic fluctuation remains present and important even at high pressure because the high-symmetry kagome lattice is unstable in nonmagnetic phase up to 30 GPa. Our results suggest the crucial role of magnetism to stabilize the crystal structure, under both ambient and high pressure.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"58 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: On-surface synthesis of triangulene trimers via dehydration reaction 作者更正：通过脱水反应在表面合成三芳基三聚体

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-01 DOI: 10.1038/s41467-025-58331-2

Suqin Cheng, Zhijie Xue, Can Li, Yufeng Liu, Longjun Xiang, Youqi Ke, Kaking Yan, Shiyong Wang, Ping Yu

引用次数: 0

A toxin-antitoxin system provides phage defense via DNA damage and repair

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-01 DOI: 10.1038/s41467-025-58540-9

Huan Pu, Yuxin Chen, Xinjun Zhao, Lunzhi Dai, Aiping Tong, Dongmei Tang, Qiang Chen, Yamei Yu

引用次数: 0

Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-01 DOI: 10.1038/s41467-025-58460-8

Lisa Willemsen, Jiyeun Lee, Pramod Shinde, Ferran Soldevila, Minori Aoki, Shelby Orfield, Mari Kojima, Ricardo da Silva Antunes, Alessandro Sette, Bjoern Peters

{"title":"Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop","authors":"Lisa Willemsen, Jiyeun Lee, Pramod Shinde, Ferran Soldevila, Minori Aoki, Shelby Orfield, Mari Kojima, Ricardo da Silva Antunes, Alessandro Sette, Bjoern Peters","doi":"10.1038/s41467-025-58460-8","DOIUrl":"https://doi.org/10.1038/s41467-025-58460-8","url":null,"abstract":"Outbreaks of Bordetella pertussis (BP), the causative agent of whooping cough, continue despite broad vaccination coverage and have been increasing since vaccination switched from whole-BP (wP) to acellular BP (aP) vaccines. wP vaccination has been associated with more durable protective immunity and an induced Th1 polarized memory T cell response. Here, we profile, by a multi-omics approach, the immune response of 30 wP and 31 aP-primed individuals and identify correlates of T cell polarization before and after Tdap booster vaccination. We find that early transcriptional changes indicating an interferon response, followed by an increase in plasma IFN-γ and interferon-induced chemokine levels (peaking at day 1-3 post-booster), correlate best with the Th1 polarization of the vaccine-induced memory T cell response on day 28. Our studies indicate that wP-primed individuals maintain their Th1 polarization through this early memory interferon response. This suggests that stimulating the interferon pathway during vaccination could be an effective strategy to elicit a predominant Th1 response in aP-primed individuals that protects better against infection.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"58 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-01 DOI: 10.1038/s41467-025-58546-3

Rosa Planells-Cases, Viktoriia Vorobeva, Sumanta Kar, Franziska W. Schmitt, Uwe Schulte, Marina Schrecker, Richard K. Hite, Bernd Fakler, Thomas J. Jentsch

{"title":"Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity","authors":"Rosa Planells-Cases, Viktoriia Vorobeva, Sumanta Kar, Franziska W. Schmitt, Uwe Schulte, Marina Schrecker, Richard K. Hite, Bernd Fakler, Thomas J. Jentsch","doi":"10.1038/s41467-025-58546-3","DOIUrl":"https://doi.org/10.1038/s41467-025-58546-3","url":null,"abstract":"The function of endosomes critically depends on their ion homeostasis. A crucial role of luminal Cl−, in addition to that of H+, is increasingly recognized. Both ions are transported by five distinct endolysosomal CLC chloride/proton exchangers. Dysfunction of each of these transporters entails severe disease. Here we identified TMEM9 and TMEM9B as obligatory β-subunits for endosomal ClC-3, ClC-4, and ClC-5. Mice lacking both β-subunits displayed severely reduced levels of all three CLCs and died embryonically or shortly after birth. TMEM9 proteins regulate trafficking of their partners. Surprisingly, they also strongly inhibit CLC ion transport. Tonic inhibition enables the regulation of CLCs and prevents toxic Cl− accumulation and swelling of endosomes. Inhibition requires a carboxy-terminal TMEM9 domain that interacts with CLCs at multiple sites. Disease-causing CLCN mutations that weaken inhibition by TMEM9 proteins cause a pathogenic gain of ion transport. Our work reveals the need to suppress, in a regulated manner, endolysosomal chloride/proton exchange. Several aspects of endosomal ion transport must be revised.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"183 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-01 DOI: 10.1038/s41467-025-58432-y

Xindi Zhou, Huijing Zhang, Yaru Wang, Danni Wang, Zhiqiao Lin, Yuchao Zhang, Yubin Tang, Jianping Liu, Yu-Feng Yao, Yixiao Zhang, Lifeng Pan

{"title":"Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity","authors":"Xindi Zhou, Huijing Zhang, Yaru Wang, Danni Wang, Zhiqiao Lin, Yuchao Zhang, Yubin Tang, Jianping Liu, Yu-Feng Yao, Yixiao Zhang, Lifeng Pan","doi":"10.1038/s41467-025-58432-y","DOIUrl":"https://doi.org/10.1038/s41467-025-58432-y","url":null,"abstract":"Ubiquitination plays vital roles in modulating pathogen-host cell interactions. RNF213, a E3 ligase, can catalyze the ubiquitination of lipopolysaccharide (LPS) and is crucial for antibacterial immunity in mammals. Shigella flexneri, an LPS-containing pathogenic bacterium, has developed mechanisms to evade host antibacterial defenses during infection. However, the precise strategies by which S. flexneri circumvents RNF213-mediated antibacterial immunity remain poorly understood. Here, through comprehensive biochemical, structural and cellular analyses, we reveal that the E3 effector IpaH1.4 of S. flexneri can directly target human RNF213 via a specific interaction between the IpaH1.4 LRR domain and the RING domain of RNF213, and mediate the ubiquitination and proteasomal degradation of RNF213 in cells. Furthermore, we determine the cryo-EM structure of human RNF213 and the crystal structure of the IpaH1.4 LRR/RNF213 RING complex, elucidating the molecular mechanism underlying the specific recognition of RNF213 by IpaH1.4. Finally, our cell based functional assays demonstrate that the targeting of host RNF213 by IpaH1.4 promotes S. flexneri proliferation within infected cells. In summary, our work uncovers an unprecedented strategy employed by S. flexneri to subvert the key host immune factor RNF213, thereby facilitating bacterial proliferation during invasion.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"25 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catechol-based chemistry for hypoglycemia-responsive delivery of zinc-glucagon via hydrogel-based microneedle patch technology

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-01 DOI: 10.1038/s41467-025-58278-4

Amin GhavamiNejad, Jackie Fule Liu, Sako Mirzaie, Brian Lu, Melisa Samarikhalaj, Adria Giacca, Xiao Yu Wu

{"title":"Catechol-based chemistry for hypoglycemia-responsive delivery of zinc-glucagon via hydrogel-based microneedle patch technology","authors":"Amin GhavamiNejad, Jackie Fule Liu, Sako Mirzaie, Brian Lu, Melisa Samarikhalaj, Adria Giacca, Xiao Yu Wu","doi":"10.1038/s41467-025-58278-4","DOIUrl":"https://doi.org/10.1038/s41467-025-58278-4","url":null,"abstract":"Hypoglycemia is a serious and potentially life-threatening condition for people with insulin-dependent diabetes. To provide a safeguard against hypoglycemia, we introduce a “smart” microneedle (MN) patch that senses glucose levels and delivers a blood glucose-raising agent (Zinc-Glucagon (Z-GCN)) in response to hypoglycemia. Herein, we describe the use of catechol and boronic acid chemistry to design a self-crosslinkable hydrogel-based MN that stimulates the release of Z-GCN during hypoglycemia. In this design, the catechol groups bind to Z-GCN through metal-ligand complexation. At hyperglycemia, boronic acids react with glucose to generate cyclic boronate esters. As the glucose concentration decreases, the boronic acid groups dissociate and are favored over Z-GCN in binding with catechol, which promotes the release of Z-GCN. We fully characterize the fabricated MN in vitro. Moreover, we further evaluate the MN and demonstrate the in vivo glucose-responsive delivery of Z-GCN from the patch. We also show its effectiveness in preventing hypoglycemia for up to 6 h in type 1 diabetic male rats against two consecutive insulin overdose challenges. Since many proteins/peptides have a high binding affinity to metal ions, the introduced mechanism driven by the competitive binding of catechol-metal ions has great implications in drug delivery applications of various protein/peptide-based therapeutics.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"20 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0