Enjian He,Yahe Wu,Huan Liang,Hongtu Xu,Jiujiang Ji,Zhijun Yang,Yixuan Wang,Yen Wei,Yan Ji
{"title":"Leveraging catechol chemistry to tackle toughness-softness-work capacity tradeoff in reprogrammable liquid crystal actuators.","authors":"Enjian He,Yahe Wu,Huan Liang,Hongtu Xu,Jiujiang Ji,Zhijun Yang,Yixuan Wang,Yen Wei,Yan Ji","doi":"10.1038/s41467-025-63836-x","DOIUrl":"https://doi.org/10.1038/s41467-025-63836-x","url":null,"abstract":"Dynamic chemistry endows liquid crystal elastomers (LCEs) with reprogrammability, enabling the reversible modulation of actuation modes to adapt to diverse tasks and enhancing sustainability and lifecycle management. However, balancing toughness, softness, and work capacity remains challenging due to their inherent tradeoff, as these properties are essential for achieving high-performance and stable actuation. Here, inspired by mussel coordination chemistry, we design a macromolecular crosslinker that combines covalent crosslinking with coordination bonds to tackle this challenge. The optimized LCE achieves exceptional toughness of 28.5 MJ/m³ and low Young's modulus of 3.1 MPa, with high-temperature toughness exceeding 9.3 MJ/m³ at 90 °C (25 °C above phase transition temperature, Ti) and reaching 5.5 MJ/m³ at 120 °C (55 °C above Ti), while maintaining work capacity of 416 kJ/m³. Increasing coordination bond content further improves toughness (up to 67.0 MJ/m³) without significantly altering modulus or work capacity. Additionally, incorporating different metal ions provides a strategy akin to stem cell differentiation, transforming a single base material into variants with distinct properties. This enables spatially heterogeneous materials, paving the way for highly integrated actuators with multifunctionality.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"143 1","pages":"8782"},"PeriodicalIF":16.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Krista Freimann, Anneke Brümmer, Robert Warmerdam, Tarran S Rupall, Ana Laura Hernández-Ledesma, Joshua Chiou, Emily R Holzinger, Joseph C Maranville, Nikolina Nakic, Halit Ongen, Luca Stefanucci, Michael C Turchin, Lude Franke, Urmo Võsa, Carla P Jones, Alejandra Medina-Rivera, Gosia Trynka, Kai Kisand, Sven Bergmann, Kaur Alasoo
{"title":"Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus.","authors":"Krista Freimann, Anneke Brümmer, Robert Warmerdam, Tarran S Rupall, Ana Laura Hernández-Ledesma, Joshua Chiou, Emily R Holzinger, Joseph C Maranville, Nikolina Nakic, Halit Ongen, Luca Stefanucci, Michael C Turchin, Lude Franke, Urmo Võsa, Carla P Jones, Alejandra Medina-Rivera, Gosia Trynka, Kai Kisand, Sven Bergmann, Kaur Alasoo","doi":"10.1038/s41467-025-63856-7","DOIUrl":"https://doi.org/10.1038/s41467-025-63856-7","url":null,"abstract":"<p><p>Although genome-wide association studies have provided valuable insights into the genetic basis of complex traits and diseases, translating these findings to causal genes and their downstream mechanisms remains challenging. We performed trans expression quantitative trait locus (trans-eQTL) meta-analysis in 3734 lymphoblastoid cell line samples, identifying four robust loci that replicated in an independent multi-ethnic dataset of 682 individuals. The trans-eQTL signal at the ubiquitin specific peptidase 18 (USP18) locus colocalised with a GWAS signal for systemic lupus erythematosus (SLE). USP18 is a known negative regulator of interferon signalling and the SLE risk allele increased the expression of 50 interferon-inducible genes, suggesting that the risk allele impairs USP18's ability to effectively limit the interferon response. Intriguingly, the USP18 trans-eQTL signal would not have been discovered in a meta-analysis of up to 43,301 whole blood samples, reaffirming the importance of capturing context-specific genetic effects for GWAS interpretation.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8795"},"PeriodicalIF":15.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elmira Ebrahimi, Apiwat Sangphukieo, Hanla A Park, Valerie Gaborieau, Aida Ferreiro-Iglesias, Brenda Diergaarde, Wolfgang Ahrens, Laia Alemany, Lidia Mrb Arantes, Jaroslav Betka, Scott V Bratman, Cristina Canova, Michael Sc Conlon, David I Conway, Mauricio Cuello, Maria Paula Curado, Ana Carolina de Carvalho, Jose Carlos de Oliviera, Mark Gormley, Maryam Hadji, Sarah Hargreaves, Claire M Healy, Ivana Holcatova, Rayjean J Hung, Luis P Kowalski, Pagona Lagiou, Areti Lagiou, Geoffrey Liu, Gary J Macfarlane, Andrew F Olshan, Sandra Perdomo, Luis Felipe Ribiero Pinto, Jose Roberto V Podesta, Jerry Polesel, Miranda Pring, Hamideh Rashidian, Ricardo R Gama, Lorenzo Richiardi, Max Robinson, Paula A Rodriguez-Urrego, Stacey A Santi, Deborah P Saunders, Sheila C Soares-Lima, Nicholas Timpson, Marta Vilensky, Sandra V von Zeidler, Tim Waterboer, Kazem Zendehdel, Ariana Znaor, Paul Brennan, James McKay, Shama Virani, Tom Dudding
{"title":"Cross-ancestral GWAS identifies 29 variants across head and neck cancer subsites.","authors":"Elmira Ebrahimi, Apiwat Sangphukieo, Hanla A Park, Valerie Gaborieau, Aida Ferreiro-Iglesias, Brenda Diergaarde, Wolfgang Ahrens, Laia Alemany, Lidia Mrb Arantes, Jaroslav Betka, Scott V Bratman, Cristina Canova, Michael Sc Conlon, David I Conway, Mauricio Cuello, Maria Paula Curado, Ana Carolina de Carvalho, Jose Carlos de Oliviera, Mark Gormley, Maryam Hadji, Sarah Hargreaves, Claire M Healy, Ivana Holcatova, Rayjean J Hung, Luis P Kowalski, Pagona Lagiou, Areti Lagiou, Geoffrey Liu, Gary J Macfarlane, Andrew F Olshan, Sandra Perdomo, Luis Felipe Ribiero Pinto, Jose Roberto V Podesta, Jerry Polesel, Miranda Pring, Hamideh Rashidian, Ricardo R Gama, Lorenzo Richiardi, Max Robinson, Paula A Rodriguez-Urrego, Stacey A Santi, Deborah P Saunders, Sheila C Soares-Lima, Nicholas Timpson, Marta Vilensky, Sandra V von Zeidler, Tim Waterboer, Kazem Zendehdel, Ariana Znaor, Paul Brennan, James McKay, Shama Virani, Tom Dudding","doi":"10.1038/s41467-025-63842-z","DOIUrl":"https://doi.org/10.1038/s41467-025-63842-z","url":null,"abstract":"<p><p>Head and neck squamous cell carcinoma (HNSCC) includes diverse cancers arising in the oral cavity, oropharynx, and larynx, with the main risk factors being environmental exposures such as tobacco, alcohol, and human papillomavirus (HPV) infection. The genetic factors contributing to susceptibility across different populations and tumour subsites remain incompletely understood. Here we show, through a genome-wide association and fine mapping study of over 19,000 HNSCC cases and 38,000 controls from multiple ancestries, 18 genetic risk variants and 11 signals from fine mapping of the human leukocyte antigen (HLA) region, all previously unreported. rs78378222, a regulatory variant for TP53 is associated with a 40% reduction in overall HNSCC risk. We also identify gene-environment interactions, with BRCA2 and ADH1B variants showing effects modified by smoking and alcohol use. Subsite-specific analysis of the HLA region reveals distinct immune-related associations across HPV-positive and HPV-negative tumours. These findings refine the genetic architecture of HNSCC and highlight mechanisms linking inherited variation, immunity, and environmental exposures.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8787"},"PeriodicalIF":15.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonas Wong,Ahmad Refaat,Pablo Villacampa-Teixeira,Jonasz B Patkowski,Natalie Lapa,Julian Ortiz,Kasia Dzierlega,Blake Roberts,Stephanie Tollenaar,Matthew Croxen,Aducio Thiesen,Dina Kao,Ben Willing,Xavier Clemente-Casares,Tiago R D Costa,Wael Elhenawy
{"title":"The assembly of a hybrid type IV secretion system by a Crohn's disease-associated Escherichia coli strain.","authors":"Jonas Wong,Ahmad Refaat,Pablo Villacampa-Teixeira,Jonasz B Patkowski,Natalie Lapa,Julian Ortiz,Kasia Dzierlega,Blake Roberts,Stephanie Tollenaar,Matthew Croxen,Aducio Thiesen,Dina Kao,Ben Willing,Xavier Clemente-Casares,Tiago R D Costa,Wael Elhenawy","doi":"10.1038/s41467-025-63859-4","DOIUrl":"https://doi.org/10.1038/s41467-025-63859-4","url":null,"abstract":"Type IV secretion systems (T4SSs) are central to bacterial pathogenesis. Traditionally known for facilitating DNA transfer via conjugation, T4SSs also mediate biofilm formation. These biofilms are critical for the fitness of adherent-invasive Escherichia coli (AIEC), which are commonly isolated from Crohn's disease patients and are known for propelling gut inflammation. Many AIEC strains carry F-like plasmids encoding the IncF subgroup of T4SSs. Unlike minimized systems with 12 core components, the IncF family is an expanded T4SS with additional genes that enhance conjugation. Here, we show that a biofilm-forming AIEC strain harbors an unusual IncF plasmid that lacks two conserved components essential for T4SS functionality. This strain forms a natural hybrid T4SS where the missing components are supplied by a co-residing chromosomal T4SS on an integrative and conjugative element (ICE). Biochemical assays reveal that this hybrid T4SS drives pilin polymerization and biofilm formation on epithelial cells. Furthermore, we show that a bacterial subpopulation expresses the IncF and ICE-encoded genes in response to host cells, leading to the assembly of biofilms and enhanced fitness in the gut. These findings uncover crosstalk between two evolutionary distant mobile genetic elements to form a hybrid T4SS that mediates biofilm biogenesis by a Crohn's disease-associated pathogen.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"114 1","pages":"8797"},"PeriodicalIF":16.6,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katharina T Schmid, Aikaterini Symeonidi, Dmytro Hlushchenko, Maria L Richter, Andréa E Tijhuis, Floris Foijer, Maria Colomé-Tatché
{"title":"Benchmarking scRNA-seq copy number variation callers.","authors":"Katharina T Schmid, Aikaterini Symeonidi, Dmytro Hlushchenko, Maria L Richter, Andréa E Tijhuis, Floris Foijer, Maria Colomé-Tatché","doi":"10.1038/s41467-025-62359-9","DOIUrl":"https://doi.org/10.1038/s41467-025-62359-9","url":null,"abstract":"<p><p>Copy number variations (CNVs), the gain or loss of genomic regions, are associated with disease, especially cancer. Single cell technologies offer new possibilities to capture within-sample heterogeneity of CNVs and identify subclones relevant for tumor progression and treatment outcome. Several computational tools have been developed to identify CNVs from scRNA-seq data. However, an independent benchmarking of them is lacking. Here, we evaluate six popular methods in their ability to correctly identify ground truth CNVs, euploid cells and subclonal structures in 21 scRNA-seq datasets. We discover dataset-specific factors influencing the performance, including dataset size, the number and type of CNVs in the sample and the choice of the reference dataset. Methods which include allelic information perform more robustly for large droplet-based datasets, but require higher runtime. Furthermore, the methods differ in their additional functionalities. We offer a benchmarking pipeline to identify the optimal method for new datasets, and improve methods' performance.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8777"},"PeriodicalIF":15.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rebeka Butkovič, Michael D Healy, Cecilia de Heus, Alexander P Walker, Wyatt Beyers, Kerrie E McNally, Philip A Lewis, Kate J Heesom, Nalan Liv, Judith Klumperman, Santiago Di Pietro, Brett M Collins, Peter J Cullen
{"title":"Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7.","authors":"Rebeka Butkovič, Michael D Healy, Cecilia de Heus, Alexander P Walker, Wyatt Beyers, Kerrie E McNally, Philip A Lewis, Kate J Heesom, Nalan Liv, Judith Klumperman, Santiago Di Pietro, Brett M Collins, Peter J Cullen","doi":"10.1038/s41467-025-63855-8","DOIUrl":"https://doi.org/10.1038/s41467-025-63855-8","url":null,"abstract":"<p><p>The endosomal Commander assembly associates with the sorting nexin-17 (SNX17) cargo adaptor to regulate cell surface recycling of internalised integral proteins including integrins and lipoprotein receptors. Here, we identify leucine rich melanocyte differentiation associated (LRMDA) as a Commander binding protein. We reveal that LRMDA and SNX17 share a common mechanism of Commander association, and that LRMDA simultaneously associates with Commander and active RAB32, establishing distinct RAB32-LRMDA-Commander and SNX17-Commander assemblies. Functional analysis in melanocytes reveals distinct roles for RAB32-LRMDA-Commander and SNX17-Commander in melanosome biogenesis. We reveal how LRMDA mutations, causative for oculocutaneous albinism type 7, a hypopigmentation disorder accompanied by poor visual acuity, uncouple RAB32 and Commander binding thereby establishing the mechanistic basis of this disease. Our discovery of this alternative Commander assembly highlights the plasticity of Commander function in human pigmentation and extends the Commander function beyond the SNX17-mediated regulation of cell surface proteome.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8794"},"PeriodicalIF":15.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robby Concha-Eloko, Beatriz Beamud, Pilar Domingo-Calap, Rafael Sanjuán
{"title":"Unlocking data in Klebsiella lysogens to predict capsular type-specificity of phage depolymerases.","authors":"Robby Concha-Eloko, Beatriz Beamud, Pilar Domingo-Calap, Rafael Sanjuán","doi":"10.1038/s41467-025-63861-w","DOIUrl":"https://doi.org/10.1038/s41467-025-63861-w","url":null,"abstract":"<p><p>Viral entry is a critical step in the infection process. Klebsiella spp. and other clinically relevant bacteria often express complex polysaccharide capsules that act as a barrier to phage entry. In turn, most lytic phages targeting Klebsiella encode depolymerases for capsule removal. This virus-host arms race leads to extensive genetic diversity in both capsules and depolymerases, complicating our ability to understand their interaction. This study exploits the genetic information encoded in Klebsiella prophages to model the interplay between the bacteria, the prophages, and their depolymerases, using a directed acyclic graph and a sequence clustering-based method. Both approaches show significant predictive ability for prophage capsular tropism and, importantly, are transferrable to lytic phages. In addition to creating a comprehensive database linking depolymerase sequences to their specific targets, this study demonstrates the predictability of phage-host interactions at the subspecies level, providing insights for improving the therapeutic and industrial applicability of phages.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8798"},"PeriodicalIF":15.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tobias Hainer, Erik Fransson, Sangita Dutta, Julia Wiktor, Paul Erhart
{"title":"A morphotropic phase boundary in MA<sub>1-x</sub>FA<sub>x</sub>PbI<sub>3</sub>: linking structure, dynamics, and electronic properties.","authors":"Tobias Hainer, Erik Fransson, Sangita Dutta, Julia Wiktor, Paul Erhart","doi":"10.1038/s41467-025-64526-4","DOIUrl":"https://doi.org/10.1038/s41467-025-64526-4","url":null,"abstract":"<p><p>Understanding the phase behavior of mixed-cation halide perovskites is critical for optimizing their structural stability and optoelectronic performance. Here, we map the phase diagram of MA<sub>1-x</sub>FA<sub>x</sub>PbI<sub>3</sub> using a machine-learned interatomic potential in molecular dynamics simulations. We identify a morphotropic phase boundary (MPB) at approximately 27% FA content, delineating the transition between out-of-phase and in-phase octahedral tilt patterns. Phonon mode projections reveal that this transition coincides with a mode crossover composition, where the free energy landscapes of the M and R phonon modes become nearly degenerate. This results in nanoscale layered structures with alternating tilt patterns, suggesting minimal interface energy between competing phases. Our results provide a systematic and consistent description of this important system, complementing earlier partial and sometimes conflicting experimental assessments. Furthermore, density functional theory calculations show that band edge fluctuations peak near the MPB, indicating an enhancement of electron-phonon coupling and dynamic disorder effects. These findings establish a direct link between phonon dynamics, phase behavior, and electronic structure, providing a further composition-driven pathway for tailoring the optoelectronic properties of perovskite materials. By demonstrating that phonon overdamping serves as a hallmark of the MPB, our study offers insights into the design principles for stable, high-performance perovskite solar cells.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8775"},"PeriodicalIF":15.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alyssa Thomas DeCruz, Benjamin S Miller, Da Huang, Max McRobbie, Felix Donaldson, Laura E McCoy, Ciara K O'Sullivan, Johannes C Botha, Eleni Nastouli, Rachel A McKendry
{"title":"Quantum-enhanced nanodiamond rapid test advances early SARS-CoV-2 antigen detection in clinical diagnostics.","authors":"Alyssa Thomas DeCruz, Benjamin S Miller, Da Huang, Max McRobbie, Felix Donaldson, Laura E McCoy, Ciara K O'Sullivan, Johannes C Botha, Eleni Nastouli, Rachel A McKendry","doi":"10.1038/s41467-025-63066-1","DOIUrl":"https://doi.org/10.1038/s41467-025-63066-1","url":null,"abstract":"<p><p>Quantum biosensors, which harness quantum effects to detect biomarkers, could address the urgent need for more sensitive rapid diagnostics. Lateral flow tests using nitrogen-vacancy centres in nanodiamond labels offer high sensitivity and robustness by controlling the spin-dependent fluorescence to remove background. This is particularly important in complex and variable clinical samples. However, to date only model systems have been studied with few clinical samples. Here we show results of a clinical evaluation of a spin-enhanced nanodiamond test for SARS-CoV-2 antigen with 103 upper respiratory tract swab samples. We find 95.1% sensitivity (Ct ≤ 30) and 100% specificity benchmarked against RT-qPCR, with no cross-reactivity to influenza A, RSV, and Rhinovirus. Modelling with patient data yields a mean of 2.0-days earlier detection compared to conventional gold-nanoparticle tests (just 0.6 days after RT-qPCR) with 2.2-fold more patients detected on the first day of symptom onset, potentially reducing the transmission risk and protecting populations.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8778"},"PeriodicalIF":15.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis León-Alcaide, Lucía Martínez-Goyeneche, Michele Sessolo, Bruno J C Vieira, João C Waerenborgh, J Alberto Rodríguez-Velamazán, Oscar Fabelo, Matthew J Cliffe, David A Keen, Guillermo Mínguez Espallargas
{"title":"Direct synthesis of an iron metal-organic framework antiferromagnetic glass.","authors":"Luis León-Alcaide, Lucía Martínez-Goyeneche, Michele Sessolo, Bruno J C Vieira, João C Waerenborgh, J Alberto Rodríguez-Velamazán, Oscar Fabelo, Matthew J Cliffe, David A Keen, Guillermo Mínguez Espallargas","doi":"10.1038/s41467-025-63837-w","DOIUrl":"https://doi.org/10.1038/s41467-025-63837-w","url":null,"abstract":"<p><p>We present a direct route to prepare a family of MOF glasses without a meltable crystalline precursor, in contrast to the conventional melt-quenching approach. This one-step synthesis uses the linker itself as the reaction medium under an inert atmosphere, enabling the incorporation of highly hydrolytically unstable M(II) centers. This route produces high-purity iron (II) MOF glasses avoiding the oxidation and partial degradation commonly associated with the conventional melt-quenching process. The transparent glassy monoliths of formula Fe(im)<sub>2-x</sub>(bim)<sub>x</sub>, denoted as dg-MUV-29 (dg = direct-glass), can be prepared with different amounts of imidazole and benzimidazole as well as with linkers with diverse functionalities (NH<sub>2</sub>, CH<sub>3</sub>, Br, and Cl). The absence of magnetic impurities allows us to study the magnetic properties of the MOF glass itself and show that MOF glasses are good model systems for topologically-disordered amorphous antiferromagnets. We also present the functional advantages of direct-glass synthesis by creating free-standing films of glassy MOFs and integrating them in optoelectronic devices. Direct-glass synthesis is thus a powerful route to exploit the true functional potential of glassy MOFs, not only realizing further classes of MOF glasses but also unveiling properties that can be accessed with these materials.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"8783"},"PeriodicalIF":15.7,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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