Nature Communications最新文献_第7页

Machine learning-enhanced high-resolution exposure assessment of ultrafine particles.

IF 14.7 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56581-8

Yudie Jianyao, Hongyong Yuan, Guofeng Su, Jing Wang, Wenguo Weng, Xiaole Zhang

{"title":"Machine learning-enhanced high-resolution exposure assessment of ultrafine particles.","authors":"Yudie Jianyao, Hongyong Yuan, Guofeng Su, Jing Wang, Wenguo Weng, Xiaole Zhang","doi":"10.1038/s41467-025-56581-8","DOIUrl":"10.1038/s41467-025-56581-8","url":null,"abstract":"Ultrafine particles (UFPs) under 100 nm pose significant health risks inadequately addressed by traditional mass-based metrics. The WHO emphasizes particle number concentration (PNC) for assessing UFP exposure, but large-scale evaluations remain scarce. In this study, we developed a stacking-based machine learning framework integrating data-driven and physical-chemical models for a national-scale UFP exposure assessment at 1 km spatial and 1-hour temporal resolutions, leveraging long-term standardized PNC measurements in Switzerland. Approximately 20% (1.7 million) of the Swiss population experiences high UFP exposure exceeding an annual mean of 104 particles‧cm-3, with a national average of (9.3 ± 4.7)×103 particles‧cm-3, ranging from (5.5 ± 2.3)×103 (rural) to (1.4 ± 0.5)×104 particles‧cm-3 (urban). A nonlinear relationship is identified between the WHO-recommended 1-hour and 24-hour exposure reference levels, suggesting their non-interchangeability. UFP spatial heterogeneity, quantified by coefficient of variation, ranges from 4.7 ± 4.2 (urban) to 13.8 ± 15.1 (rural) times greater than PM2.5. These findings provide crucial insights for the development of future UFP standards.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"1209"},"PeriodicalIF":14.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56237-7

Bokai Zhu, Yunhao Bai, Yao Yu Yeo, Xiaowei Lu, Xavier Rovira-Clavé, Han Chen, Jason Yeung, Dingani Nkosi, Jonathan Glickman, Antonio Delgado-Gonzalez, Georg K. Gerber, Mike Angelo, Alex K. Shalek, Garry P. Nolan, Sizun Jiang

{"title":"A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment","authors":"Bokai Zhu, Yunhao Bai, Yao Yu Yeo, Xiaowei Lu, Xavier Rovira-Clavé, Han Chen, Jason Yeung, Dingani Nkosi, Jonathan Glickman, Antonio Delgado-Gonzalez, Georg K. Gerber, Mike Angelo, Alex K. Shalek, Garry P. Nolan, Sizun Jiang","doi":"10.1038/s41467-025-56237-7","DOIUrl":"https://doi.org/10.1038/s41467-025-56237-7","url":null,"abstract":"The intricate interactions between the host immune system and its microbiome constituents undergo dynamic shifts in response to perturbations to the intestinal tissue environment. Our ability to study these events on the systems level is significantly limited by in situ approaches capable of generating simultaneous insights from both host and microbial communities. Here, we introduce Microbiome Cartography (MicroCart), a framework for simultaneous in situ probing of host and microbiome across multiple spatial modalities. We demonstrate MicroCart by investigating gut host and microbiome changes in a murine colitis model, using spatial proteomics, transcriptomics, and glycomics. Our findings reveal a global but systematic transformation in tissue immune responses, encompassing tissue-level remodeling in response to host immune and epithelial cell state perturbations, bacterial population shifts, localized inflammatory responses, and metabolic process alterations during colitis. MicroCart enables a deep investigation of the intricate interplay between the host tissue and its microbiome with spatial multi-omics.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"30 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methylcobalamin protects against liver failure via engaging gasdermin E

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-024-54826-6

Wanfeng Xu, Yun Wang, Shuang Cui, Qiuling Zheng, Yanghao Lin, Qingqing Cui, Yuxin Xie, Yuming Zeng, Chuan Zhang, Yujie Li, Xin Jin, Minna Qin, Huiyong Sun, Haiping Hao, Lijuan Cao

{"title":"Methylcobalamin protects against liver failure via engaging gasdermin E","authors":"Wanfeng Xu, Yun Wang, Shuang Cui, Qiuling Zheng, Yanghao Lin, Qingqing Cui, Yuxin Xie, Yuming Zeng, Chuan Zhang, Yujie Li, Xin Jin, Minna Qin, Huiyong Sun, Haiping Hao, Lijuan Cao","doi":"10.1038/s41467-024-54826-6","DOIUrl":"https://doi.org/10.1038/s41467-024-54826-6","url":null,"abstract":"Gasdermin E (GSDME) is a pyroptotic cell death effector and a promising target for pyroptotic tissue injury. Here we perform high-throughput screening and demonstrate that methylcobalamin (MeCbl), an endogenous coenzyme form of vitamin B12, is a specific GSDME inhibitor and highly effective against cholestatic liver failure. MeCbl specifically blocks GSDME cleavage by directly binding with GSDME. In cholestasis-, cisplatin- or concanavalin A (Con A)-induced male mouse models, MeCbl significantly suppresses liver transaminase activities and inflammation, alleviates hepatocyte death, and reduces mortality of mice by blocking GSDME cleavage. The conserved Cys180 residue in GSDME is essential for caspase-3/GzmB recognition. MeCbl in base-off conformation coordinates to Cys180 to prevent caspase-3/GzmB-GSDME interactions and thereby GSDME-mediated pyroptosis. In summary, our study discovers MeCbl as a specific GSDME inhibitor that is promisingly to be developed as an effective drug against cholestatic liver failure, and other GSDME triggered sterile inflammation and/or organ failure.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De novo design of protein minibinder agonists of TLR3

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56369-w

Chloe S. Adams, Hyojin Kim, Abigail E. Burtner, Dong Sun Lee, Craig Dobbins, Cameron Criswell, Brian Coventry, Adri Tran-Pearson, Ho Min Kim, Neil P. King

引用次数: 0

Regeneration in the absence of canonical neoblasts in an early branching flatworm

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-024-54716-x

Ludwik Gąsiorowski, Chew Chai, Andrei Rozanski, Gargi Purandare, Fruzsina Ficze, Athanasia Mizi, Bo Wang, Jochen C. Rink

{"title":"Regeneration in the absence of canonical neoblasts in an early branching flatworm","authors":"Ludwik Gąsiorowski, Chew Chai, Andrei Rozanski, Gargi Purandare, Fruzsina Ficze, Athanasia Mizi, Bo Wang, Jochen C. Rink","doi":"10.1038/s41467-024-54716-x","DOIUrl":"https://doi.org/10.1038/s41467-024-54716-x","url":null,"abstract":"The remarkable regenerative abilities of flatworms are closely linked to neoblasts – adult pluripotent stem cells that are the only division-competent cell type outside of the reproductive system. Although the presence of neoblast-like cells and whole-body regeneration in other animals has led to the idea that these features may represent the ancestral metazoan state, the evolutionary origin of both remains unclear. Here we show that the catenulid Stenostomum brevipharyngium, a member of the earliest-branching flatworm lineage, lacks conventional neoblasts despite being capable of whole-body regeneration and asexual reproduction. Using a combination of single-nuclei transcriptomics, in situ gene expression analysis, and functional experiments, we find that cell divisions are not restricted to a single cell type and are associated with multiple fully differentiated somatic tissues. Furthermore, the cohort of germline multipotency genes, which are considered canonical neoblast markers, are not expressed in dividing cells, but in the germline instead, and we experimentally show that they are neither necessary for proliferation nor regeneration. Overall, our results challenge the notion that canonical neoblasts are necessary for flatworm regeneration and open up the possibility that neoblast-like cells may have evolved convergently in different animals, independent of their regenerative capacity.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"20 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transient pulsed discharge preparation of graphene aerogel supports asymmetric Cu cluster catalysts promote CO₂ electroreduction.

IF 14.7 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56534-1

Kaiyuan Liu, Hao Shen, Zhiyi Sun, Qiang Zhou, Guoqiang Liu, Zhongti Sun, Wenxing Chen, Xin Gao, Pengwan Chen

{"title":"Transient pulsed discharge preparation of graphene aerogel supports asymmetric Cu cluster catalysts promote CO2 electroreduction.","authors":"Kaiyuan Liu, Hao Shen, Zhiyi Sun, Qiang Zhou, Guoqiang Liu, Zhongti Sun, Wenxing Chen, Xin Gao, Pengwan Chen","doi":"10.1038/s41467-025-56534-1","DOIUrl":"10.1038/s41467-025-56534-1","url":null,"abstract":"Designing asymmetrical structures is an effective strategy to optimize metallic catalysts for electrochemical carbon dioxide reduction reactions. Herein, we demonstrate a transient pulsed discharge method for instantaneously constructing graphene-aerogel supports asymmetric copper nanocluster catalysts. This process induces the convergence of copper atoms decomposed by copper chloride onto graphene originating from the intense current pulse and high temperature. The catalysts exhibit asymmetrical atomic and electronic structures due to lattice distortion and oxygen doping of copper clusters. In carbon dioxide reduction reaction, the selectivity and activity for ethanol production are enhanced by the asymmetric structure and abundance of active sites on catalysts, achieving a Faradaic efficiency of 75.3% for ethanol and 90.5% for multicarbon products at -1.1 V vs. reversible hydrogen electrode. Moreover, the strong interactions between copper nanoclusters and graphene-aerogel support confer notable long-term stability. We elucidate the key reaction intermediates and mechanisms on Cu4O-Cu/C2O1 moieties through in situ testing and density functional theory calculations. This study provides an innovative approach to balancing activity and stability in asymmetric-structure catalysts for energy conversion.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"1203"},"PeriodicalIF":14.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction.

IF 14.7 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56343-6

Oleg Mikhajlov, Ram M Adar, Maria Tătulea-Codrean, Anne-Sophie Macé, John Manzi, Fanny Tabarin, Aude Battistella, Fahima di Federico, Jean-François Joanny, Guy Tran van Nhieu, Patricia Bassereau

{"title":"Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction.","authors":"Oleg Mikhajlov, Ram M Adar, Maria Tătulea-Codrean, Anne-Sophie Macé, John Manzi, Fanny Tabarin, Aude Battistella, Fahima di Federico, Jean-François Joanny, Guy Tran van Nhieu, Patricia Bassereau","doi":"10.1038/s41467-025-56343-6","DOIUrl":"10.1038/s41467-025-56343-6","url":null,"abstract":"Integrin clusters facilitate mechanical force transmission (mechanotransduction) and regulate biochemical signaling during cell adhesion. However, most studies have focused on rigid substrates. On fluid substrates like supported lipid bilayers (SLBs), integrin ligands are mobile, and adhesive complexes are traditionally thought unable to anchor for cell spreading. Here, we demonstrate that cells spread on SLBs coated with Invasin, a high-affinity integrin ligand. Unlike SLBs functionalized with RGD peptides, integrin clusters on Invasin-SLBs grow in size and complexity comparable to those on glass. While actomyosin contraction dominates adhesion maturation on stiff substrates, we find that on fluid SLBs, integrin mechanotransduction and cell spreading rely on dynein pulling forces along microtubules perpendicular to the membranes and microtubules pushing on adhesive complexes, respectively. These forces, potentially present on non-deformable surfaces, are revealed in fluid substrate systems. Supported by a theoretical model, our findings demonstrate a mechanical role for microtubules in integrin clustering.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"1201"},"PeriodicalIF":14.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degeneracy-breaking and long-lived multimode microwave electromechanical systems enabled by cubic silicon-carbide membrane crystals.

IF 14.7 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56497-3

Yulong Liu, Huanying Sun, Qichun Liu, Haihua Wu, Mika A Sillanpää, Tiefu Li

{"title":"Degeneracy-breaking and long-lived multimode microwave electromechanical systems enabled by cubic silicon-carbide membrane crystals.","authors":"Yulong Liu, Huanying Sun, Qichun Liu, Haihua Wu, Mika A Sillanpää, Tiefu Li","doi":"10.1038/s41467-025-56497-3","DOIUrl":"10.1038/s41467-025-56497-3","url":null,"abstract":"Cubic silicon-carbide crystals (3C-SiC), known for their high thermal conductivity and in-plane stress, hold significant promise for the development of high-quality (Q) mechanical oscillators. We reveal degeneracy-breaking phenomena in 3C-phase crystalline silicon-carbide membrane and present high-Q mechanical modes in pairs or clusters. The 3C-SiC material demonstrates excellent microwave compatibility with superconducting circuits. Thus, we can establish a coherent electromechanical interface, enabling precise control over 21 high-Q mechanical modes from a single 3C-SiC square membrane. Benefiting from extremely high mechanical frequency stability, this interface enables tunable light slowing with group delays extending up to an impressive duration of an hour. Coherent energy transfer between distinct mechanical modes are also presented. In this work, the studied 3C-SiC membrane crystal with their significant properties of multiple acoustic modes and high-quality factors, provide unique opportunities for the encoding, storage, and transmission of quantum information via bosonic phonon channels.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"1207"},"PeriodicalIF":14.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucomannan engineering highlights roles of galactosyl modification in fine-tuning cellulose-glucomannan interaction in Arabidopsis cell walls

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56626-y

Yoshihisa Yoshimi, Li Yu, Rosalie Cresswell, Xinyu Guo, Alberto Echevarría-Poza, Jan J. Lyczakowski, Ray Dupree, Toshihisa Kotake, Paul Dupree

{"title":"Glucomannan engineering highlights roles of galactosyl modification in fine-tuning cellulose-glucomannan interaction in Arabidopsis cell walls","authors":"Yoshihisa Yoshimi, Li Yu, Rosalie Cresswell, Xinyu Guo, Alberto Echevarría-Poza, Jan J. Lyczakowski, Ray Dupree, Toshihisa Kotake, Paul Dupree","doi":"10.1038/s41467-025-56626-y","DOIUrl":"https://doi.org/10.1038/s41467-025-56626-y","url":null,"abstract":"Widely found in most plant lineages, β-mannans are structurally diverse polysaccharides that can bind to cellulose fibrils to form the complex polysaccharide architecture of the cell wall. How changes in polysaccharide structure influence its cell wall solubility or promote appropriate interaction with cellulose fibrils is poorly understood. Glucomannan backbones acquire variable patterns of galactosyl substitutions, depending on plant developmental stage and species. Here, we show that fine-tuning of galactosyl modification on glucomannans is achieved by the differing acceptor recognition of mannan α-galactosyltransferases (MAGTs). Biochemical analysis and 13C solid-state　nuclear magnetic resonance spectroscopy of Arabidopsis with cell wall glucomannan engineered by MAGTs reveal that the degree of galactosylation strongly affects the interaction with cellulose. The findings indicate that plants tailor galactosyl modification on glucomannans for constructing an appropriate cell wall architecture, paving the way to convert properties of lignocellulosic biomass for better use.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"20 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of functional covalent organic framework films by modulator and solvent induced polymerization

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-024-55114-z

Xuerong Li, Xingyue Ji, Xinglong Zhang, Xinyi Chen, Hongfeng Li, Suoying Zhang, Fengwei Huo, Weina Zhang

{"title":"Construction of functional covalent organic framework films by modulator and solvent induced polymerization","authors":"Xuerong Li, Xingyue Ji, Xinglong Zhang, Xinyi Chen, Hongfeng Li, Suoying Zhang, Fengwei Huo, Weina Zhang","doi":"10.1038/s41467-024-55114-z","DOIUrl":"https://doi.org/10.1038/s41467-024-55114-z","url":null,"abstract":"Covalent organic frameworks are attractive candidates for the next generation films in technical applications. However, due to their crystallization nature, insolubility in common solvents as well as infusible at high temperatures make it challenging to grow them spontaneously or process them into films. Herein, we report an efficient strategy to fabricate covalent organic framework films based on a modulator-solvent induced polymerization process. The addition of modulator slows down the nucleation rate during the initial stages of covalent organic framework growth, resulting in the formation of fluidic precursors that are easy to process. Subsequently, a suitable drying process is introduced to balance the evaporation rate of solvent and the crystallization rate of modulator induced, resulting in the formation of covalent organic framework films with a mixture of amorphous and crystalline structures. This strategy is universal for the fabrication of several types of covalent organic framework films with large-scale and freestanding state. Moreover, covalent organic framework films with asymmetric structure can function as organic vapor-triggered actuators, offering excellent repeatability and reversibility. By introducing functional molecules such as fluorescence, chirality and catalyst during the nucleation process, versatile functional covalent organic framework films can be easily fabricated, which endow them with broader application prospects.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"24 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0