Nature Communications最新文献_第6页

Superior energy-storage performance in BaTiO3-based MLCCs via high-entropy driven multiscale optimization 基于高熵驱动多尺度优化的batio3基mlcc储能性能优越

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-79047-x

Ying Jiang, Kezhen Hui, Peiyao Zhao, Jiaming Liu, Jinsong Cui, Xu Cheng, Menghan Li, Shuyan Huang, Xinjie Wang, Limin Guo, Xiaohui Wang

{"title":"Superior energy-storage performance in BaTiO3-based MLCCs via high-entropy driven multiscale optimization","authors":"Ying Jiang, Kezhen Hui, Peiyao Zhao, Jiaming Liu, Jinsong Cui, Xu Cheng, Menghan Li, Shuyan Huang, Xinjie Wang, Limin Guo, Xiaohui Wang","doi":"10.1038/s41467-026-79047-x","DOIUrl":"https://doi.org/10.1038/s41467-026-79047-x","url":null,"abstract":"Multilayer ceramic capacitors are essential components in modern electronic devices. However, achieving superior performance under high-temperature and high-electric-field remains a huge challenge due to the increased leakage current and limited breakdown strength. Herein, a high-entropy driven multiscale optimization strategy is proposed for lead-free multilayer ceramic capacitors. This approach integrates multiple elements into both A- and B-sites at the atomic scale, engineers polymorphic domain coexistence at the phase scale, and introduces a uniform SiO2 coating layer on grain surfaces to form a core–shell structure while refining grain size at the grain scale. Furthermore, a SiO2 barrier layer is constructed between the electrodes and ceramics at the device scale. Remarkably, high-entropy BaTiO3-based Multilayer ceramic capacitors achieve an ultra-high energy density of 19.8 J·cm−3 and a high efficiency of 89.3% at 1421 kV·cm−1, along with an outstanding high-temperature energy storage performance. The high-entropy driven multiscale optimization strategy offers a universal approach to enhancing the overall energy storage performance of advanced dielectric capacitors.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"34 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal proteomics reveals dynamic antiparallel gradients shaping signalling waves 时空蛋白质组学揭示了动态反平行梯度塑造信号波

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-78911-0

Wilke H. M. Meijer, Virginia Andrade, Suzan Stelloo, Wouter M. Thomas, Marek J. van Oostrom, Balaji Srinivasan, Dimitri Fabreges, Sita Venkataraman, Sonja D. C. Weterings, Jan-Daniël de Leede-Scheven, Eveline F. Ilcken, Kim T. J. Peters, Michiel Vermeulen, Katharina F. Sonnen

{"title":"Spatiotemporal proteomics reveals dynamic antiparallel gradients shaping signalling waves","authors":"Wilke H. M. Meijer, Virginia Andrade, Suzan Stelloo, Wouter M. Thomas, Marek J. van Oostrom, Balaji Srinivasan, Dimitri Fabreges, Sita Venkataraman, Sonja D. C. Weterings, Jan-Daniël de Leede-Scheven, Eveline F. Ilcken, Kim T. J. Peters, Michiel Vermeulen, Katharina F. Sonnen","doi":"10.1038/s41467-026-78911-0","DOIUrl":"https://doi.org/10.1038/s41467-026-78911-0","url":null,"abstract":"Embryonic development is driven by dynamic protein networks, yet how these dynamics shape morphogenesis remains poorly understood. Somitogenesis, the rhythmic segmentation of vertebrate embryos, is controlled by signalling gradients and oscillations in the presomitic mesoderm (PSM), but the underlying protein dynamics remain largely unknown. Here, we combine microfluidic synchronisation of mouse embryo tails with quantitative proteomics and transcriptomics to resolve spatiotemporal protein dynamics during somitogenesis. We identify proteins with dynamic expression during somitogenesis and reveal an antiparallel, dynamic R-Spondin/LGR signalling pattern that explains how Wnt oscillation amplitude increases despite declining Wnt ligand levels in the anterior PSM. Dynamic ligand expression is validated in mouse gastruloids, and perturbation of ligand dynamics reduces oscillation amplitude and impairs somite formation. Together, our findings identify R-Spondin as a dynamic amplifier of Wnt signalling oscillations and provide a mechanistic framework for understanding how protein dynamics regulate mammalian tissue patterning.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"96 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-shot synthesis of rare gastrointestinal lesions improves diagnostic accuracy and clinical training 一针合成罕见的胃肠道病变，提高诊断的准确性和临床培训

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-78492-y

Jia Yu, Yan Zhu, Peiyao Fu, Tianyi Chen, Zhihua Wang, Fei Wu, Quanlin Li, Pinghong Zhou, Shuo Wang, Xian Yang

{"title":"One-shot synthesis of rare gastrointestinal lesions improves diagnostic accuracy and clinical training","authors":"Jia Yu, Yan Zhu, Peiyao Fu, Tianyi Chen, Zhihua Wang, Fei Wu, Quanlin Li, Pinghong Zhou, Shuo Wang, Xian Yang","doi":"10.1038/s41467-026-78492-y","DOIUrl":"https://doi.org/10.1038/s41467-026-78492-y","url":null,"abstract":"Rare gastrointestinal lesions are infrequently encountered in routine endoscopy, limiting data for developing reliable artificial intelligence (AI) models and training novice clinicians. Here we present EndoRare, a one-shot, retraining-free generative framework that synthesizes diverse lesion exemplars from a single reference image. Using language-guided concept disentanglement, EndoRare separates pathognomonic lesion features from non-diagnostic attributes, encoding the former into a learnable prototype embedding while varying the latter to ensure diversity. We validate EndoRare across four rare pathologies: calcifying fibrous tumor, juvenile polyposis syndrome, familial adenomatous polyposis, and Peutz-Jeghers syndrome. Experts judge the synthetic images clinically plausible, and data augmentation significantly improves downstream AI classifiers, increasing true positive rates at low false-positive rates. In an exploratory reader study, exposure to EndoRare-generated cases is associated with improved image-level recognition by novice endoscopists. These findings support the potential use of EndoRare as a data-efficient tool for rare-lesion education and motivate prospective controlled validation.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable roll-to-roll laser processing for high value application of low-grade carbon fiber materials 可编程卷对卷激光加工用于低等级碳纤维材料的高价值应用

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-79120-5

Guangmeng Chen, Wenjie Yu, Yanhua Jiang, Li Jia, Ziqiang Hu, Weiwei Zhao, Xiaosu Yi, Xiaoqing Liu

引用次数: 0

From microstructure to function: spatial visualization of magnetic permeability 从微观结构到功能：磁导率的空间可视化

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-79271-5

Ke Pei, Ruixuan Zhang, Wenbin You, Chao Wang, Chendi Yang, Xiaowei Lv, Zhengchen Wu, Yizheng Wu, Xuebing Zhao, Renchao Che

{"title":"From microstructure to function: spatial visualization of magnetic permeability","authors":"Ke Pei, Ruixuan Zhang, Wenbin You, Chao Wang, Chendi Yang, Xiaowei Lv, Zhengchen Wu, Yizheng Wu, Xuebing Zhao, Renchao Che","doi":"10.1038/s41467-026-79271-5","DOIUrl":"https://doi.org/10.1038/s41467-026-79271-5","url":null,"abstract":"Understanding the physics of high-frequency magnetic response is essential for advancing electromagnetic materials. Here, a general strategy is presented for visualizing magnetic permeability as a spatially distributed, frequency-dependent field, instead of a uniform bulk parameter. Our framework reveals that high-frequency magnetic loss arises from coherent spin-wave propagation and interference, leading to spatially selective energy absorption and localized regions of negative imaginary permeability. Tailoring geometric connectivity to suppress spin-wave propagation enables the selective enhancement of localized resonances. Such resonance enables deterministic control over high-frequency response through structural design. The principle is further examined in nanoscale iron spheres. Their surface morphology plays a decisive role in reorganizing the internal resonance domains. This structural reconfiguration, in turn, reshapes the broadband magnetic permeability spectra. To navigate the high-dimensional space of surface defect configurations, machine learning models are integrated with micromagnetic simulations, allowing rapid prediction of magnetic performance across microwave bands. Computational modeling provides an ideal platform to complement experimental exploration. The physic-data framework reveals geometry-to-spectra design rules, validated on iron nanoparticles. This framework uniquely bridges the microscopic spin dynamics with electromagnetic response, enabling tunable high-frequency materials for communication and sensing.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"14 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NYNRIN safeguards leukemia stem cells by sustaining thioredoxin activity to maintain redox homeostasis NYNRIN通过维持硫氧还蛋白活性来维持氧化还原稳态，从而保护白血病干细胞

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-78678-4

Jianming Wang, Qiang Gong, Yinghao Fu, Yijia Liu, Yu Luo, Siqi Luo, Linwei He, Jiankun Fan, Lei Li, Yu Hou, Zhe Chen, Xueya Zhao

{"title":"NYNRIN safeguards leukemia stem cells by sustaining thioredoxin activity to maintain redox homeostasis","authors":"Jianming Wang, Qiang Gong, Yinghao Fu, Yijia Liu, Yu Luo, Siqi Luo, Linwei He, Jiankun Fan, Lei Li, Yu Hou, Zhe Chen, Xueya Zhao","doi":"10.1038/s41467-026-78678-4","DOIUrl":"https://doi.org/10.1038/s41467-026-78678-4","url":null,"abstract":"Leukemia stem cells (LSCs) primarily rely on mitochondrial oxidative phosphorylation (OXPHOS) for energy production, a metabolic feature that inevitably generates excessive reactive oxygen species (ROS). NYNRIN (NYN domain and retroviral integrase containing) is highly expressed in LSC-like cells and is associated with poor prognosis in patients with acute myeloid leukemia (AML). Genetic targeting of NYNRIN impairs LSC-like cell maintenance and in vivo leukemogenic capacity in MLL-AF9- and HOXA9/MEIS1-driven AML models, and compromises the in vivo pathogenicity of patient-derived LSC-like cells. Mechanistically, NYNRIN sustains thioredoxin (Trx) activity by functioning as an RNA-binding protein that directly binds and degrades TXNIP mRNA via its NYN domain. Loss of NYNRIN stabilizes TXNIP mRNA, leading to TXNIP accumulation, which disrupts Trx-mediated redox buffering, induces ROS overproduction and mitochondrial dysfunction, and triggers LSC apoptosis. Notably, NYNRIN inhibition potentiates venetoclax efficacy by compromising Trx-mediated ROS clearance, lowering the apoptotic threshold of LSCs. Collectively, our findings reveal a critical NYNRIN-TXNIP-Trx axis that safeguards LSCs by enabling efficient ROS clearance.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"34 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arabian hydroclimate and hominin population dynamics over the last 500,000 years 过去50万年阿拉伯水文气候和人类种群动态

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-78983-y

Liang Zhou, Zhaoxia Jiang, Sanzhong Li, Juan C. Larrasoaña, Andrew P. Roberts, Shixia Yang, Qingsong Liu, Liang Chen, Zhengxin Yin, Wanxin Liu, Yulong Guan, Yuzhen Zhang, Michael D. Petraglia

{"title":"Arabian hydroclimate and hominin population dynamics over the last 500,000 years","authors":"Liang Zhou, Zhaoxia Jiang, Sanzhong Li, Juan C. Larrasoaña, Andrew P. Roberts, Shixia Yang, Qingsong Liu, Liang Chen, Zhengxin Yin, Wanxin Liu, Yulong Guan, Yuzhen Zhang, Michael D. Petraglia","doi":"10.1038/s41467-026-78983-y","DOIUrl":"https://doi.org/10.1038/s41467-026-78983-y","url":null,"abstract":"Despite the discovery of a rich Palaeolithic archaeological record in Arabia over the last decade, the environmental context of hominin occupations and dispersals remains poorly understood owing to the paucity of Pleistocene palaeoenvironmental records. Here we show a multi-proxy, high-resolution dust record from the western equatorial Indian Ocean spanning the last 500,000 years, which enables evaluation of the influence of orbital-scale hydrological variations on hominin populations in Arabia. The dust evidence reinforces the view that hominin presence in Arabia was driven by enhanced monsoon precipitation during so-called Green Arabia periods. These results, coupled with hunter-gatherer demographic data, point to marked hominin population expansions during prolonged wetter periods. Hominin occupation, however, was not linked exclusively to traditional humid periods. Brief phases of high-intensity rainfall within some glacial periods, manifested by transient high dust contents associated with enhanced terrestrial moisture availability and increased supply of wind-erodible particles, also favoured hominin expansions.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"79 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spin-adapted neural network wavefunctions in real space 真实空间中的自旋适应神经网络波函数

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-78600-y

Ruichen Li, Yuzhi Liu, Du Jiang, Yixiao Chen, Xuelan Wen, Wenrui Li, Di He, Liwei Wang, Ji Chen, Weiluo Ren

{"title":"Spin-adapted neural network wavefunctions in real space","authors":"Ruichen Li, Yuzhi Liu, Du Jiang, Yixiao Chen, Xuelan Wen, Wenrui Li, Di He, Liwei Wang, Ji Chen, Weiluo Ren","doi":"10.1038/s41467-026-78600-y","DOIUrl":"https://doi.org/10.1038/s41467-026-78600-y","url":null,"abstract":"Spin plays a fundamental role in understanding electronic structure, yet many real-space wavefunction methods fail to adequately consider it. We introduce the spin-adapted antisymmetrization method, a general procedure that enforces exact total spin symmetry for antisymmetric many-electron wavefunctions in real space. In the context of neural network-based quantum Monte Carlo, our method leverages the expressiveness of deep neural networks to capture electron correlation while enforcing exact spin adaptation via group representation theory. This framework provides a principled route to embed physical priors into otherwise black-box neural network wavefunctions, yielding a compact representation of correlated systems with neural network orbitals. To demonstrate its effectiveness, we study the spin ladder of iron-sulfur clusters, a long-standing challenge for many-body methods due to their dense spectrum of nearly degenerate spin states. Our results reveal accurate resolution of low-lying spin states and spin gaps in [Fe2S2] and [Fe4S4] clusters, offering insights into their electronic structures. In sum, these findings establish our framework as a practical route toward spin-adapted neural network-based quantum Monte Carlo for strongly correlated systems.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"5 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intensified human pressures threaten global mountain vertebrate biodiversity 人类压力加剧威胁着全球山地脊椎动物的生物多样性

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-78392-1

Jianfeng Sun, Guangdong Li, Yue Cao, Ying Zhang, James E. M. Watson, Jianguo Liu

{"title":"Intensified human pressures threaten global mountain vertebrate biodiversity","authors":"Jianfeng Sun, Guangdong Li, Yue Cao, Ying Zhang, James E. M. Watson, Jianguo Liu","doi":"10.1038/s41467-026-78392-1","DOIUrl":"https://doi.org/10.1038/s41467-026-78392-1","url":null,"abstract":"Mountain ecosystems host rich biodiversity and often act as last refuges for species under growing human pressure. However, the extent and recent trajectory of anthropogenic impacts on global mountain biodiversity remain poorly understood. Here, we evaluate spatio-temporal changes in human pressure across 6717 mountain ranges worldwide from 2000 to 2020 and assess future exposure to anthropogenic pressures under three Shared Socioeconomic Pathways (SSPs). We show that more than 60% of mountain ranges are exposed to elevated human pressure and that intensification of human pressure between 2000 and 2020 is associated with the loss of 71.69 Mha of natural mountain habitat. Protected areas provide incomplete buffering from human pressure, while substantial representation gaps remain for mountain vertebrates: 4234 species have less than 10% of their mountain-specific area of habitat represented within protected areas, including 1165 threatened species. We further identify mountain ranges where high biodiversity importance coincides with limited protection and elevated future exposure to land-use change, with priority rankings remaining broadly consistent across socioeconomic scenarios. Together, these results identify persistent conservation gaps and mountain systems where future conservation action could contribute to global biodiversity targets.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"79 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unconventional DNA architecture in a dopamine–bound aptamer complex 多巴胺结合适体复合体中的非常规DNA结构

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-78792-3

Emily Hoi Pui Chao, Eric Largy, Yunus A. Kaiyum, Minh-Dat Nguyen, Brune Vialet, Philippe Dauphin-Ducharme, Philip E. Johnson, Cameron D. Mackereth

引用次数: 0