Nature Communications最新文献_第6页

Ground-state flavin-dependent enzymes catalyzed enantioselective radical trifluoromethylation

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56437-1

Xinyu Duan, Dong Cui, Mengdi Wang, Chenlu Jin, Xiaochen Cai, Zhiguo Wang, Jian Xu

{"title":"Ground-state flavin-dependent enzymes catalyzed enantioselective radical trifluoromethylation","authors":"Xinyu Duan, Dong Cui, Mengdi Wang, Chenlu Jin, Xiaochen Cai, Zhiguo Wang, Jian Xu","doi":"10.1038/s41467-025-56437-1","DOIUrl":"https://doi.org/10.1038/s41467-025-56437-1","url":null,"abstract":"The introduction of fluoroalkyl groups into pharmaceutical compounds has the potential to enhance their therapeutic properties. Nevertheless, the synthesis of enantiomerically pure C(sp³)–CF₃ compounds poses a significant challenge. Biocatalysis offers precise stereochemical control, however, the scarcity of fluorine-containing natural products makes it difficult to find enzymes capable of incorporating fluoroalkyl groups. Herein, we develop a ground-state flavin-dependent enzyme-catalyzed strategy for the radical-mediated enantioselective trifluoromethylation. Two engineered flavin-dependent enzymes are successfully developed to catalyze stereoselective hydrotrifluoromethylation and trifluoromethyl-alkyl cross-electrophile coupling reactions using trifluoromethyl thianthrenium triflate as a radical donor. Experimental investigations and computational simulations demonstrate that the reaction is initiated through single-electron transfer from the ground state flavin hydroquinone (FMNhq) and quenched through hydrogen atom transfer by flavin semiquinone (FMNsq). This strategy provides an opportunity to bridge the gap between biocatalysis and organic fluorides but also introduces an alternative approach to address challenging stereoselective fluoroalkylation reactions in organic synthesis.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"60 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sub-nanometer depth resolution and single dopant visualization achieved by tilt-coupled multislice electron ptychography

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56499-1

Zehao Dong, Yang Zhang, Chun-Chien Chiu, Sicheng Lu, Jianbing Zhang, Yu-Chen Liu, Suya Liu, Jan-Chi Yang, Pu Yu, Yayu Wang, Zhen Chen

{"title":"Sub-nanometer depth resolution and single dopant visualization achieved by tilt-coupled multislice electron ptychography","authors":"Zehao Dong, Yang Zhang, Chun-Chien Chiu, Sicheng Lu, Jianbing Zhang, Yu-Chen Liu, Suya Liu, Jan-Chi Yang, Pu Yu, Yayu Wang, Zhen Chen","doi":"10.1038/s41467-025-56499-1","DOIUrl":"https://doi.org/10.1038/s41467-025-56499-1","url":null,"abstract":"Real-space, three-dimensional imaging of atomic structures in materials science is a critical yet challenging task. Although scanning transmission electron microscopy has achieved sub-angstrom lateral resolution through techniques like electron ptychography, depth resolution remains limited to only 2 to 3 nanometers using single-projection setups. Attaining better depth resolution often requires large sample tilt angles and numerous projections, as demonstrated in atomic electron tomography. Here, we introduce an extension of multislice electron ptychography, which couples only a few small-angle projections to improve depth resolution by more than threefold, reaching the sub-nanometer scale and potentially approaching the atomic level. This technique maintains high resolving power for both light and heavy atoms, significantly enhancing the detection of individual dopants. We experimentally demonstrate three-dimensional visualization of dilute praseodymium dopants in a brownmillerite oxide, Ca2Co2O5, along with the accompanying lattice distortions. This approach can be implemented on widely available transmission electron microscopes equipped with hybrid pixel detectors, with data processing achievable using high-performance computing systems.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"79 1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction.

IF 14.7 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56506-5

Rui Liu, Zongwei Li, Rui Chen, Zhihong Fang, Zhiqiang Liu, Huan Liu

引用次数: 0

Artificial Intelligence (AI)-driven approach to climate action and sustainable development

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-024-53956-1

Haein Cho, Emmanuel Ackom

引用次数: 0

A high-entropy alloy showing gigapascal superelastic stress and nearly temperature-independent modulus

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56580-9

Junming Gou, Guoxin Liu, Tianzi Yang, Xiaolian Liu, Yun Pan, Chang Liu, Yu Qian, Yao Liu, Ying Chen, Xuefeng Zhang, Tianyu Ma, Xiaobing Ren

{"title":"A high-entropy alloy showing gigapascal superelastic stress and nearly temperature-independent modulus","authors":"Junming Gou, Guoxin Liu, Tianzi Yang, Xiaolian Liu, Yun Pan, Chang Liu, Yu Qian, Yao Liu, Ying Chen, Xuefeng Zhang, Tianyu Ma, Xiaobing Ren","doi":"10.1038/s41467-025-56580-9","DOIUrl":"https://doi.org/10.1038/s41467-025-56580-9","url":null,"abstract":"High-performance superelastic materials with a combination of high superelastic stress, large elastic recovery strain, and stable elastic modulus over a wide temperature range are highly desired for a variety of technological applications. Unfortunately, it is difficult to achieve these multi-functionalities simultaneously because most superelastic materials have to encounter the modulus softening effect and the limited superelastic stress, whereas most Elinvar-type materials show small elastic strain limit. Here, we report a (TiZrHf)44Ni25Cu15Co10Nb6 high-entropy alloy that meets all these requirements. This alloy also shows good cyclic stability, thermally-stable capacity for elastic energy storage, high micro-hardness and good corrosion resistance, allowing it to operate stably in hostile environments. We show that its multi-functionalities stem from a natural composite microstructure, containing a highly-distorted matrix phase with strain glass transition and various structural and compositional heterogeneities from micro- to nano-scale. Our findings may provide insight into designing high-entropy alloys with unconventional and technologically-important functional properties.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"39 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contact ion-pair SN2 reactions activated by Lewis Base Phase transfer catalysts

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-024-55795-6

Ju Gyeong Jeong, Young-Ho Oh, Tae Hyun Park, Sung-Sik Lee, Dong Wook Kim, Sungyul Lee

{"title":"Contact ion-pair SN2 reactions activated by Lewis Base Phase transfer catalysts","authors":"Ju Gyeong Jeong, Young-Ho Oh, Tae Hyun Park, Sung-Sik Lee, Dong Wook Kim, Sungyul Lee","doi":"10.1038/s41467-024-55795-6","DOIUrl":"https://doi.org/10.1038/s41467-024-55795-6","url":null,"abstract":"We present experimental probes of contact ion-pair (CIP) SN2 reactions for simplest prototype systems by 19F-NMR spectroscopy. This study provides crucial evidences for the reactions of CIP metal salts facilitated by Lewis base phase transfer catalysts (PTCs) [2,2,2]-cryptand, 18-crown-6, pentaethylene glycols (pentaEGs) and BINOL–based pentaEG. The 19F-NMR spectra of MF (M = K, Cs) ion-pairs in various solvents are used as fingerprinting tools to identify the CIP CsF/PTC/substrate complexes in SN2 reactions. Examination of the prototype reactions demonstrates that the novel CIP mechanism, which is in sharp contrast to the conventional perspectives, may account for the observed phenomenal efficiency of the SN2 processes using the alkali metal salts under the influence of various PTCs. In this extremely efficient and selective protocol of wide applicability, the CIP MF is activated by the Lewis base PTCs acting on the counter-cation M+ to drastically mitigate the latter’s retarding Coulomb forces on the adjacent nucleophile F-, with or without the participation of hydrogen bonds.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"77 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143072831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resolving active species during the carbon monoxide oxidation over Pt(111) on the microsecond timescale

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56576-5

Calley N. Eads, Weijia Wang, Ulrike Küst, Julia Prumbs, Robert H. Temperton, Mattia Scardamaglia, Joachim Schnadt, Jan Knudsen, Andrey Shavorskiy

{"title":"Resolving active species during the carbon monoxide oxidation over Pt(111) on the microsecond timescale","authors":"Calley N. Eads, Weijia Wang, Ulrike Küst, Julia Prumbs, Robert H. Temperton, Mattia Scardamaglia, Joachim Schnadt, Jan Knudsen, Andrey Shavorskiy","doi":"10.1038/s41467-025-56576-5","DOIUrl":"https://doi.org/10.1038/s41467-025-56576-5","url":null,"abstract":"Catalytic studies traditionally rely on steady-state conditions resulting in time-averaged datasets that do not differentiate between active and spectator species. This limitation can cause misinterpretations of catalytic function, as the signal of short-lived intermediates responsible for producing desired reaction products is often masked by more intense spectator species. Time-resolved ambient pressure X-ray photoelectron spectroscopy (tr-APXPS) mitigates this issue by combining microsecond time resolution under reaction conditions. Using tr-APXPS, we investigate the oxidation of CO over Pt(111) by concurrently tracking reaction products, surface intermediates, and catalyst response. Our findings reveal that chemisorbed oxygen, rather than Pt surface oxide, is the main species reacting with CO to form CO2, supporting a primary Langmuir-Hinshelwood mechanism. The results shed new light on a heavily-debated reaction in catalysis. Beyond using CO pulses to determine active species, we demonstrate how careful tuning of pulsing parameters can be used for dynamic catalyst operation to enhance CO2 formation.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"4 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56456-y

Yuchuan Zhou, Liang Zeng, Linbo Cai, Wang Zheng, Xinglong Liu, Yuqi Xiao, Xiaoya Jin, Yang Bai, Mingyao Lai, Hainan Li, Hua Jiang, Songling Hu, Yan Pan, Jianghong Zhang, Chunlin Shao

{"title":"Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma","authors":"Yuchuan Zhou, Liang Zeng, Linbo Cai, Wang Zheng, Xinglong Liu, Yuqi Xiao, Xiaoya Jin, Yang Bai, Mingyao Lai, Hainan Li, Hua Jiang, Songling Hu, Yan Pan, Jianghong Zhang, Chunlin Shao","doi":"10.1038/s41467-025-56456-y","DOIUrl":"https://doi.org/10.1038/s41467-025-56456-y","url":null,"abstract":"Glioblastoma multiforme (GBM) remains a therapeutic challenge due to its aggressive nature and recurrence. This study establishes a radioresistant GBM cell model through repeated irradiation and observes a cellular senescence-like phenotype in these cells. Comprehensive genomic and transcriptomic analyses identify IFI16 as a central regulator of this phenotype and contributes to radioresistance. IFI16 activates HMOX1 transcription thereby attenuating ferroptosis by reducing lipid peroxidation, ROS production, and intracellular Fe2+ content following irradiation. Furthermore, IFI16 interacts with the transcription factors JUND and SP1 through its pyrin domain, robustly facilitating HMOX1 expression, further inhibiting ferroptosis and enhancing radioresistance in GBM. Notably, glyburide, a sulfonylurea compound, effectively disrupts IFI16 function and enhances ferroptosis and radiosensitivity. By targeting the pyrin domain of IFI16, glyburide emerges as a potential therapeutic agent against GBM radioresistance. These findings underscore the central role of IFI16 in GBM radioresistance and offer promising avenues to improve GBM treatment.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"60 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measuring mean radiant temperature for indoor comfort assessment using low-resolution optical sensors

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-024-55122-z

Fatih Evren, Sayan Biswas, Richard Graves

{"title":"Measuring mean radiant temperature for indoor comfort assessment using low-resolution optical sensors","authors":"Fatih Evren, Sayan Biswas, Richard Graves","doi":"10.1038/s41467-024-55122-z","DOIUrl":"https://doi.org/10.1038/s41467-024-55122-z","url":null,"abstract":"Measuring and controlling human thermal perception-related parameters within the built environment is crucial for ensuring occupant comfort, productivity, well-being, and reduced energy consumption. The human body is sensitive to both convective and radiative thermal effects. Mean radiant temperature represents the comprehensive radiant thermal impact individuals perceive in their surroundings. However, no feasible, robust, and ergonomic methods exist for real-time mean radiant temperature measurements in the built environment. In this paper, we introduce a method for measuring longwave mean radiant temperature utilizing low-resolution infrared temperature sensors. The approach utilizes projective transformations to derive surface temperature distributions from raw infrared thermal data. Our technique is tested in four diverse real-world environments, encompassing different heating methods and room configurations, resulting in a maximum error of ±0.5 °C. The results demonstrate the method’s repeatability and robustness across diverse room sizes, layouts, and scenarios, suggesting its potential integration into room thermostats to improve human comfort while optimizing building energy utilization. We anticipate that this method will revolutionize sensing in the built environment by eliminating the requirement for costly hardware.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"22 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versatile nitrate-respiring heterotrophs are previously concealed contributors to sulfur cycle.

IF 14.7 1区综合性期刊

Nature Communications Pub Date : 2025-01-31 DOI: 10.1038/s41467-025-56588-1

Bo Shao, Yuan-Guo Xie, Long Zhang, Yang Ruan, Bin Liang, Ruochen Zhang, Xijun Xu, Wei Wang, Zhengda Lin, Xuanyuan Pei, Xueting Wang, Lei Zhao, Xu Zhou, Xiaohui Wu, Defeng Xing, Aijie Wang, Duu-Jong Lee, Nanqi Ren, Donald E Canfield, Brian P Hedlund, Zheng-Shuang Hua, Chuan Chen

{"title":"Versatile nitrate-respiring heterotrophs are previously concealed contributors to sulfur cycle.","authors":"Bo Shao, Yuan-Guo Xie, Long Zhang, Yang Ruan, Bin Liang, Ruochen Zhang, Xijun Xu, Wei Wang, Zhengda Lin, Xuanyuan Pei, Xueting Wang, Lei Zhao, Xu Zhou, Xiaohui Wu, Defeng Xing, Aijie Wang, Duu-Jong Lee, Nanqi Ren, Donald E Canfield, Brian P Hedlund, Zheng-Shuang Hua, Chuan Chen","doi":"10.1038/s41467-025-56588-1","DOIUrl":"10.1038/s41467-025-56588-1","url":null,"abstract":"Heterotrophic denitrifiers play crucial roles in global carbon and nitrogen cycling. However, their inability to oxidize sulfide renders them vulnerable to this toxic molecule, which inhibits the key enzymatic reaction responsible for reducing nitrous oxide (N2O), thereby raising greenhouse gas emissions. Here, we applied microcosm incubations, community-isotope-corrected DNA stable-isotope probing, and metagenomics to characterize a cohort of heterotrophic denitrifiers in estuarine sediments that thrive by coupling sulfur oxidation with denitrification through chemolithoheterotrophic metabolism. Remarkably, ecophysiology experiments from enrichments demonstrate that such heterotrophs expedite denitrification with sulfur acting as alternative electron sources and substantially curtail N2O emissions in both organic-rich and organic-limited environments. Their flexible, non-sulfur-dependent physiology may confer competitive advantages over conventional heterotrophic denitrifiers in detoxifying sulfide, adapting to organic matter fluctuations, and mitigating greenhouse gas emissions. Our study provides insights into the ecological role of heterotrophic denitrifiers in microbial communities with implications for sulfur cycling and climate change.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"1202"},"PeriodicalIF":14.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0