Nature Communications最新文献_第6页

GWAS meta-analysis using a graph-based pan-genome enhanced gene mining efficiency for agronomic traits in rice

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-03 DOI: 10.1038/s41467-025-58081-1

Longbo Yang, Wenchuang He, Yiwang Zhu, Yang Lv, Yilin Li, Qianqian Zhang, Yifan Liu, Zhiyuan Zhang, Tianyi Wang, Hua Wei, Xinglan Cao, Yan Cui, Bin Zhang, Wu Chen, Huiying He, Xianmeng Wang, Dandan Chen, Congcong Liu, Chuanlin Shi, Xiangpei Liu, Qiang Xu, Qiaoling Yuan, Xiaoman Yu, Hongge Qian, Xiaoxia Li, Bintao Zhang, Hong Zhang, Yue Leng, Zhipeng Zhang, Xiaofan Dai, Mingliang Guo, Juqing Jia, Qian Qian, Lianguang Shang

{"title":"GWAS meta-analysis using a graph-based pan-genome enhanced gene mining efficiency for agronomic traits in rice","authors":"Longbo Yang, Wenchuang He, Yiwang Zhu, Yang Lv, Yilin Li, Qianqian Zhang, Yifan Liu, Zhiyuan Zhang, Tianyi Wang, Hua Wei, Xinglan Cao, Yan Cui, Bin Zhang, Wu Chen, Huiying He, Xianmeng Wang, Dandan Chen, Congcong Liu, Chuanlin Shi, Xiangpei Liu, Qiang Xu, Qiaoling Yuan, Xiaoman Yu, Hongge Qian, Xiaoxia Li, Bintao Zhang, Hong Zhang, Yue Leng, Zhipeng Zhang, Xiaofan Dai, Mingliang Guo, Juqing Jia, Qian Qian, Lianguang Shang","doi":"10.1038/s41467-025-58081-1","DOIUrl":"https://doi.org/10.1038/s41467-025-58081-1","url":null,"abstract":"Genome-wide association studies (GWASs) encounter limitations from population structure and sample size, restricting their efficacy. Though meta-analysis mitigates these issues, its application in rice research remains limited. Here, we report a large-scale meta-analysis of six independent GWAS experiments in rice to mine genes for key agronomic traits. By integrating a rice pan-genome graph to identify structural variants, we obtained 6,604,898 SNP and 42,879 PAV variants for the six panels (7765 accessions). Meta-analysis significantly improved quantitative trait loci (QTLs) detection and hidden heritability by up to 43 and 37.88%, respectively. Among 156 QTLs identified for six agronomic traits, 116 were exclusively detected through meta-analysis, highlighting its superior resolution. Two novel QTLs governing grain width and length were functionally validated through CRISPR/Cas9, confirming their candidate genes. Our findings underscore the utility and potential advantages of this pan-genome-based meta-GWAS approach, providing a scalable model for efficiently gene mining from diverse rice germplasms.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"7 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-03 DOI: 10.1038/s41467-025-57951-y

Joseph Cichon, Thomas T. Joseph, Xinguo Lu, Andrzej Z. Wasilczuk, Max B. Kelz, Steven J. Mennerick, Charles F. Zorumski, Peter Nagele

{"title":"Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect","authors":"Joseph Cichon, Thomas T. Joseph, Xinguo Lu, Andrzej Z. Wasilczuk, Max B. Kelz, Steven J. Mennerick, Charles F. Zorumski, Peter Nagele","doi":"10.1038/s41467-025-57951-y","DOIUrl":"https://doi.org/10.1038/s41467-025-57951-y","url":null,"abstract":"Nitrous oxide (N2O) induces rapid and durable antidepressant effects. The cellular and circuit mechanisms mediating this process are not known. Here we find that a single dose of inhaled N2O induces rapid and specific activation of layer V (L5) pyramidal neurons in the cingulate cortex of rodents exposed to chronic stress conditions. N2O-induced L5 activation rescues a stress-associated hypoactivity state, persists following exposure, and is necessary for its antidepressant-like activity. Although NMDA-receptor antagonism is believed to be a primary mechanism of action for N2O, L5 neurons activate even when NMDA-receptor function is attenuated through both pharmacological and genetic approaches. By examining different molecular and circuit targets, we identify N2O-induced inhibition of calcium-sensitive potassium (SK2) channels as a key molecular interaction responsible for driving specific L5 activity along with ensuing antidepressant-like effects. These results suggest that N2O-induced L5 activation is crucial for its fast antidepressant action and this effect involves novel and specific molecular actions in distinct cortical cell types.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"23 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-03 DOI: 10.1038/s41467-025-58241-3

Jiaming Wang, Kang Lv, Yilu Wen, Tao Liu, Changgui Zhao

{"title":"Enantio-, atrop-, and diastereoselective macrolactonization to access type III cyclophanes","authors":"Jiaming Wang, Kang Lv, Yilu Wen, Tao Liu, Changgui Zhao","doi":"10.1038/s41467-025-58241-3","DOIUrl":"https://doi.org/10.1038/s41467-025-58241-3","url":null,"abstract":"Although chiral substituents have been incorporated into ansa chains to stabilize the conformations of cyclophanes and modulate the biological activities of pharmaceuticals, the asymmetric syntheses of these atropisomers relies on substrate-induced diastereoselective macrocyclization. To the best of our knowledge, enantio-, atrop-, and diastereoselective macrocyclizations are yet to be reported. Herein, we describe an N-heterocyclic carbene (NHC) and chiral phosphoric acid (CPA) dual-catalytic process for the desymmetrization of 1,3-diols, to achieve macrocyclization and stereoselective control over two chiral elements. It is deduced that the hydrogen bonding of CPA with the 1,3-diols enhances the diastereoselectivity of the process. As a result, various planar-chiral cyclophanes bearing chiral ansa chains are synthesized. Thermodynamic experiments reveal that the presence of an all-carbon quaternary carbon center on the ansa chain significantly increases the rotational barriers of the cyclophanes. Moreover, density functional theory calculations suggest that the chiral substituent shrinks the ansa chain by compressing the bond angle, thereby rendering the conformational rotation reaction more challenging.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global floating kelp forests have limited protection despite intensifying marine heatwave threats

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-03 DOI: 10.1038/s41467-025-58054-4

Nur Arafeh-Dalmau, Juan Carlos Villaseñor-Derbez, David S. Schoeman, Alejandra Mora-Soto, Tom W. Bell, Claire L. Butler, Maycira Costa, Loyiso V. Dunga, Henry F. Houskeeper, Cristian Lagger, Carolina Pantano, Daniela Laínez del Pozo, Kerry J. Sink, Jennifer Sletten, Timothe Vincent, Fiorenza Micheli, Kyle C. Cavanaugh

{"title":"Global floating kelp forests have limited protection despite intensifying marine heatwave threats","authors":"Nur Arafeh-Dalmau, Juan Carlos Villaseñor-Derbez, David S. Schoeman, Alejandra Mora-Soto, Tom W. Bell, Claire L. Butler, Maycira Costa, Loyiso V. Dunga, Henry F. Houskeeper, Cristian Lagger, Carolina Pantano, Daniela Laínez del Pozo, Kerry J. Sink, Jennifer Sletten, Timothe Vincent, Fiorenza Micheli, Kyle C. Cavanaugh","doi":"10.1038/s41467-025-58054-4","DOIUrl":"https://doi.org/10.1038/s41467-025-58054-4","url":null,"abstract":"Kelp forests are one of the earth’s most productive ecosystems and are at great risk from climate change, yet little is known regarding their current conservation status and global future threats. Here, by combining a global remote sensing dataset of floating kelp forests with climate data and projections, we find that exposure to projected marine heatwaves will increase ~6 to ~16 times in the long term (2081–2100) compared to contemporary (2001–2020) exposure. While exposure will intensify across all regions, some southern hemisphere areas which have lower exposure to contemporary and projected marine heatwaves may provide climate refugia for floating kelp forests. Under these escalating threats, less than 3% of global floating kelp forests are currently within highly restrictive marine protected areas (MPAs), the most effective MPAs for protecting biodiversity. Our findings emphasize the urgent need to increase the global protection of floating kelp forests and set bolder climate adaptation goals.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nickel catalyzed C-N coupling of haloarenes with B2N4 reagents

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-03 DOI: 10.1038/s41467-025-58438-6

Qianqian Chang, Qini Li, Yi-Hui Deng, Tian-Yu Sun, Yun-Dong Wu, Leifeng Wang

引用次数: 0

Electro-activated indigos intensify ampere-level CO2 reduction to CO on silver catalysts

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-03 DOI: 10.1038/s41467-025-58593-w

Zhengyuan Li, Xing Li, Ruoyu Wang, Astrid Campos Mata, Carter S. Gerke, Shuting Xiang, Anmol Mathur, Lingyu Zhang, Dian-Zhao Lin, Tianchen Li, Krish N. Jayarapu, Andong Liu, Lavanya Gupta, Anatoly I. Frenkel, V. Sara Thoi, Pulickel M. Ajayan, Soumyabrata Roy, Yuanyue Liu, Yayuan Liu

{"title":"Electro-activated indigos intensify ampere-level CO2 reduction to CO on silver catalysts","authors":"Zhengyuan Li, Xing Li, Ruoyu Wang, Astrid Campos Mata, Carter S. Gerke, Shuting Xiang, Anmol Mathur, Lingyu Zhang, Dian-Zhao Lin, Tianchen Li, Krish N. Jayarapu, Andong Liu, Lavanya Gupta, Anatoly I. Frenkel, V. Sara Thoi, Pulickel M. Ajayan, Soumyabrata Roy, Yuanyue Liu, Yayuan Liu","doi":"10.1038/s41467-025-58593-w","DOIUrl":"https://doi.org/10.1038/s41467-025-58593-w","url":null,"abstract":"The electrochemical reduction of carbon dioxide (CO2) to carbon monoxide (CO) is challenged by a selectivity decline at high current densities. Here we report a class of indigo-based molecular promoters with redox-active CO2 binding sites to enhance the high-rate conversion of CO2 to CO on silver (Ag) catalysts. Theoretical calculations and in situ spectroscopy analyses demonstrate that the synergistic effect at the interface of indigo-derived compounds and Ag nanoparticles could activate CO2 molecules and accelerate the formation of key intermediates (*CO2– and *COOH) in the CO pathway. Indigo derivatives with electron-withdrawing groups further reduce the overpotential for CO production upon optimizing the interfacial CO2 binding affinity. By integrating the molecular design of redox-active centres with the defect engineering of Ag structures, we achieve a Faradaic efficiency for CO exceeding 90% across a current density range of 0.10 − 1.20 A cm–2. The Ag mass activity toward CO increases to 174 A mg–1Ag. This work showcases that employing redox-active CO2 sorbents as surface modification agents is a highly effective strategy to intensify the reactivity of electrochemical CO2 reduction.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"141 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-02 DOI: 10.1038/s41467-025-58333-0

Jiawei Su, Zhuoya Yu, Zhengji Yin, Zixuan Zhang, Jun Zhao, Yufei Meng, Renjie Li, Yiwei Gao, Hongwei Zhang, Rilei Yu, Yan Zhao

{"title":"Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition","authors":"Jiawei Su, Zhuoya Yu, Zhengji Yin, Zixuan Zhang, Jun Zhao, Yufei Meng, Renjie Li, Yiwei Gao, Hongwei Zhang, Rilei Yu, Yan Zhao","doi":"10.1038/s41467-025-58333-0","DOIUrl":"https://doi.org/10.1038/s41467-025-58333-0","url":null,"abstract":"The α6β4 nicotinic acetylcholine receptor (nAChR) is found in the sensory neurons of dorsal root ganglia. It is a promising therapeutic target for pain. However, the difficultly of heterologous functional expression of α6β4 receptor has hindered the discovery of drugs that target it. Here, we functionally express the human α6β4 receptor and determine the cryo-EM structures of α6β4 receptor in complex with its agonists, nicotine and the preclinical drug tebanicline. These structures were captured in non-conducting desensitized states. We elucidate that the stoichiometry of α- and β- subunits in the α6β4 receptor is 2α6:3β4. Furthermore, we identify the binding pockets for nicotine and tebanicline, demonstrating the essential residues contributing to ligand affinity and providing detailed molecular insights into why these agonists have different binding affinities despite both occupying the orthosteric site of the α6β4 receptor. These structures offer significant molecular insight into the function and ligand recognition of α6β4 receptor.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"58 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amyloid-reoriented enzyme catalysis

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-02 DOI: 10.1038/s41467-025-58536-5

Taka Sawazaki, Fuma Murai, Kai Yamamoto, Daisuke Sasaki, Youhei Sohma

{"title":"Amyloid-reoriented enzyme catalysis","authors":"Taka Sawazaki, Fuma Murai, Kai Yamamoto, Daisuke Sasaki, Youhei Sohma","doi":"10.1038/s41467-025-58536-5","DOIUrl":"https://doi.org/10.1038/s41467-025-58536-5","url":null,"abstract":"Enzyme catalysis is essential for molecular transformations. Here, we make use of amyloid, a fibrillar aggregate formed by stacking peptides with β-sheet, which offers unique selectivity in enzymatic reactions. Azo-stilbene derivative (ASB), the amyloid-recognition motif, is incorporated into the substrate, which allows the amyloid consisting of Bz-Phe-Phe-Ala-Ala-Leu-Leu-NH2 (BL7) to shield the substrates from the approaching enzyme. X-ray crystallographic analysis and structure-shielding effect relationship studies of BL7 reveal that the benzene rings present in the N-terminal benzoyl group and Phe1 side chain are particularly important for the shielding effect on the substrate. The finding results in a selective transformation system in which the reactive site close to ASB is protected by amyloid, while a site far from ASB is converted by the enzymes (trypsin, protein arginine deiminase [PAD], and Staphylococcus aureus V-8 Protease [Glu-C]). Further, the amyloid-shielded enzyme catalysis is compatible with an intact peptide, as the side chain of Tyr can be converted to the amyloid-recognizing motif. The enzymatic reactions combining amyloid provide unique selectivity for molecular transformation which may be used in diverse fields, including in synthetic chemistry.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"9 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A unique mechanism of snRNP core assembly

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-02 DOI: 10.1038/s41467-025-58461-7

Yingzhi Wang, Xiaoshuang Chen, Xi Kong, Yunfeng Chen, Zixi Xiang, Yue Xiang, Yan Hu, Yan Hou, Shijie Zhou, Congcong Shen, Li Mu, Dan Su, Rundong Zhang

{"title":"A unique mechanism of snRNP core assembly","authors":"Yingzhi Wang, Xiaoshuang Chen, Xi Kong, Yunfeng Chen, Zixi Xiang, Yue Xiang, Yan Hu, Yan Hou, Shijie Zhou, Congcong Shen, Li Mu, Dan Su, Rundong Zhang","doi":"10.1038/s41467-025-58461-7","DOIUrl":"https://doi.org/10.1038/s41467-025-58461-7","url":null,"abstract":"The assembly of most spliceosomal snRNP cores involves seven Sm proteins (D1/D2/F/E/G/D3/B) forming a ring around snRNA, typically requiring essential assembly chaperones like the SMN complex, associated with spinal muscular atrophy (SMA). Strikingly, in budding yeast, snRNP core assembly only involves Brr1, a nonessential homolog of Gemin2. Here, we reveal two distinct pathways in budding yeast: an inefficient chaperone-mediated pathway involving Brr1 and a novel factor, Lot5, and a direct pathway. Lot5 binds D1/D2/F/E/G to form a heterohexameric ring (6S). Brr1 binds D1/D2/F/E/G and 6S but cannot displace Lot5 to facilitate assembly. Disruption of BRR1 and LOT5 genes caused mild growth retardation, but LOT5 overexpression substantially impeded growth. The direct pathway uniquely involves F/E/G as a trimer and a stable D1/D2/F/E/G intermediate complex, explaining the non-essentiality of chaperones. These findings unveil a unique snRNP core assembly mechanism, illuminate the evolution of assembly chaperones, and suggest avenues for studying SMA pathophysiology.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"107 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport SLC19A1 介导的叶酸和环状二核苷酸转运的分子基础

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-04-02 DOI: 10.1038/s41467-025-58378-1

Qixiang Zhang, Xuyuan Zhang, Kexin Liu, Yalan Zhu, Xiaohua Nie, Junxiao Ma, Panpan Sun, Zhaolong Li, Yina Gao, Songqing Liu, Ang Gao, Liguo Zhang, Pu Gao

{"title":"Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport","authors":"Qixiang Zhang, Xuyuan Zhang, Kexin Liu, Yalan Zhu, Xiaohua Nie, Junxiao Ma, Panpan Sun, Zhaolong Li, Yina Gao, Songqing Liu, Ang Gao, Liguo Zhang, Pu Gao","doi":"10.1038/s41467-025-58378-1","DOIUrl":"https://doi.org/10.1038/s41467-025-58378-1","url":null,"abstract":"The solute carrier protein SLC19A1 is crucial for transporting folate nutrients, antifolate chemotherapeutics, and more recently cyclic dinucleotides (CDNs) immune transmitters, influencing various physiological and pathological processes. While the inward-open state of human SLC19A1 (hSLC19A1) has been previously described, key aspects regarding its conformational dynamics, substrate selectivity, and precise mechanisms underlying CDNs transport remain elusive. Using an antibody-facilitated conformation screening strategy, we present cryo-electron microscopy structures of hSLC19A1 in its outward-open state with and without bound substrates, revealing detailed mechanisms of substrate recognition and conformational changes during transport. We identify both general and specific features for folate/antifolate recognition, including an SLC19A1-specific pocket for accommodating γ-carboxylate-modified antifolates. Intriguingly, CDNs bind as monomers within the canonical pocket of outward-open hSLC19A1, contrasting with dimeric binding in inward-open structures. Together with functional assays, these findings provide a framework for developing antifolate drugs and CDN-targeted therapies, advancing our understanding of SLC19A1’s physiological and therapeutic functions.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"67 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0