Nature Communications最新文献_第5页

Complementary axes of functional system integrity and integration with divergent clinical correlates characterize focal epilepsy 局灶性癫痫的特征是功能系统完整性的互补轴和临床相关性的分散轴

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-79018-2

Qirui Zhang, Arielle Dascal, Sam S. Javidi, Ankeeta Ankeeta, Michael R. Sperling, Zhiqiang Zhang, Joseph I. Tracy

{"title":"Complementary axes of functional system integrity and integration with divergent clinical correlates characterize focal epilepsy","authors":"Qirui Zhang, Arielle Dascal, Sam S. Javidi, Ankeeta Ankeeta, Michael R. Sperling, Zhiqiang Zhang, Joseph I. Tracy","doi":"10.1038/s41467-026-79018-2","DOIUrl":"https://doi.org/10.1038/s41467-026-79018-2","url":null,"abstract":"Focal epilepsy affects distributed brain systems, yet characterizations of patient-specific network organization that are clinically meaningful remain limited. Using resting-state functional MRI, we estimated overlapping individualized networks and derived two complementary axes (1) network correspondence, indexing system integrity through canonical system expression, and (2) k-hubness, indexing cross-system integration through multi-network participation. We studied a presurgical cohort of 305 patients with focal epilepsy and 224 healthy participants and an independent validation cohort of 903 patients spanning focal and common generalized and childhood epilepsy syndromes and 666 healthy participants. Correspondence disruption was broadly shared across focal epilepsies, whereas k-hubness alterations showed lateralized and syndrome-dependent redistributions of cross-system integration. The axes shared variance but showed modest preferential associations, with correspondence relating to cognition and k-hubness to epilepsy clinical features. Together, these measures characterize common and heterogeneous alterations in individualized brain system organization, linking complementary aspects of network topology to cognitive and clinical variation.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"59 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural dynamics of substrate processing by the p97-Ufd1-Npl4-FAF1 machinery p97-Ufd1-Npl4-FAF1机械加工衬底的结构动力学

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-78639-x

Athina Drakonaki, Johannes van den Boom, Alexander Kröning, Hemmo Meyer, Christos Gatsogiannis

引用次数: 0

Active locomotion predictively rescues head direction attractor dynamics in head-fixed mice 主动运动可预测性地挽救头部固定小鼠的头部方向吸引子动力学

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-79031-5

Alexandr Pak, Janna Aarse, Heng Wei Zhu, Jean-Paul Noel, Simón Carrillo Segura, André A. Fenton, Dora Angelaki

{"title":"Active locomotion predictively rescues head direction attractor dynamics in head-fixed mice","authors":"Alexandr Pak, Janna Aarse, Heng Wei Zhu, Jean-Paul Noel, Simón Carrillo Segura, André A. Fenton, Dora Angelaki","doi":"10.1038/s41467-026-79031-5","DOIUrl":"https://doi.org/10.1038/s41467-026-79031-5","url":null,"abstract":"Head direction (HD) cells in the anterodorsal thalamic nucleus form the brain’s internal compass, and are often modeled as a ring attractor maintaining azimuth coding by leveraging continuous visual and inertial sensory input. Here, we test how the common experimental preparation of head-fixed animals alters this code. Complete head-fixation that creates vestibular conflict disrupts both unit and population encoding of head direction, while selectively constraining head-on-body movements either in real or virtual reality uniquely impairs HD population activity. More specifically, attractor dynamics are altered in head-restrained male mice during periods of immobility, and a computational model recapitulates this effect by perturbing lateral connectivity among HD neurons. These dynamics recover several hundred milliseconds prior to locomotion onset, suggesting that an efference copy or prediction of a re-afferent signal is necessary to maintain HD network activity during head restraint. More generally, the results indicate that the HD network is a context- and state-dependent predictive estimator, stabilized by forthcoming self-motion signals. The classic ring-attractor models should be revised to integrate context-dependent dynamics with prospective motor signals, offering a more complete account of how the brain’s compass remains stable across both naturalistic and constrained conditions.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"253 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multi-functionally integrated modular catalyst for efficient chemoselective hydrogenation 高效化学选择性加氢的多功能集成模块化催化剂

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-79017-3

Yu Pan, Yingtian Zhang, Qingpeng Cheng, Qicheng Zhang, Yajie Cao, Wenyu Xiang, Haifeng Cong, Riguang Zhang, Jorge Gascon, Xingang Li

{"title":"A multi-functionally integrated modular catalyst for efficient chemoselective hydrogenation","authors":"Yu Pan, Yingtian Zhang, Qingpeng Cheng, Qicheng Zhang, Yajie Cao, Wenyu Xiang, Haifeng Cong, Riguang Zhang, Jorge Gascon, Xingang Li","doi":"10.1038/s41467-026-79017-3","DOIUrl":"https://doi.org/10.1038/s41467-026-79017-3","url":null,"abstract":"Chemoselective hydrogenation of nitroarenes containing multiple reducible groups remains challenging due to the intrinsic activity–selectivity trade-off of conventional metal catalysts. Here we report a multi-functional Pt-based catalyst, modularly integrating molecular-sieving feedstock separation, hydrogen activation, intermediate transport and surface reaction like a nanofactory. Structurally, ~3 nm Pt nanoparticles supported on sodium titanate are encapsulated by oxygen vacancies-enriched TiOx overlayers that only permit hydrogen to adsorb on Pt particles for dissociation while preventing substrate contact. The generated active hydrogen species subsequently migrate to the catalyst surface and hydrogenate nitro groups adsorbed on surface Lewis basic oxygen vacancies, enabling an efficient condensation pathway while avoiding the use of corrosive and environmentally unfriendly alkaline solvents. The spatially decoupled yet functionally synergistic catalytic design achieves 90% 3-vinylaniline yield from 3-nitrostyrene under mild conditions with an unprecedented turnover frequency of 83,200 h−1, exceeding all previously reported metal catalysts, and exhibits broad generality toward diverse substituted nitroarenes. Collectively, these findings provide a powerful catalyst design strategy for steering complex reaction networks via spatially modular catalysis.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"253 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular basis for DNA cleavage by the mini-RNA-guided endonuclease Casδ−1 mini- rna引导的核酸内切酶Casδ−1切割DNA的分子基础

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-79084-6

Sen Yin, Zhijia Yang, Zhao Li, Keli Zhu, Jingge Wang, Feng Ye, Panpan Sun, Ang Gao, Jinsheng Lai, Yalan Zhu

{"title":"Molecular basis for DNA cleavage by the mini-RNA-guided endonuclease Casδ−1","authors":"Sen Yin, Zhijia Yang, Zhao Li, Keli Zhu, Jingge Wang, Feng Ye, Panpan Sun, Ang Gao, Jinsheng Lai, Yalan Zhu","doi":"10.1038/s41467-026-79084-6","DOIUrl":"https://doi.org/10.1038/s41467-026-79084-6","url":null,"abstract":"CRISPR-Cas adaptive immune systems are powerful and versatile tools for genome engineering. CRISPR-Casδ−1 is a recently discovered, evolutionarily distinct endonuclease that enables versatile cross-kingdom genome editing under miniature RNA-guiding. In this study, we present a comprehensive biochemical and structural characterization of CRISPR-Casδ−1. Biochemical analysis not only verifies that Casδ−1 exhibits robust double-stranded DNA cleavage activity and target-dependent trans-cleavage activity, but also explores in depth its precise cleavage sites and substrate saturation. Furthermore, we determine a 3.04 Å resolution cryo-EM structure of the Casδ−1-crRNA-dsDNA ternary complex, which reveals the molecular basis of protospacer-adjacent motif (PAM) recognition, crRNA-DNA heteroduplex assembly, and RuvC domain-mediated DNA cleavage. Collectively, our study reveals the structural basis and evolutionary insights into Casδ−1, advances the mechanistic understanding of type V CRISPR-Cas effectors, and offers opportunities for the rational design of CRISPR-Casδ−1 as a versatile genome-editing tool.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"5 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating anonymized genome re-identification using polygenic predictions and its implications for data privacy 利用多基因预测评估匿名基因组再鉴定及其对数据隐私的影响

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-78494-w

Théo Cavinato, Robin J. Hofmeister, Zoltán Kutalik

{"title":"Evaluating anonymized genome re-identification using polygenic predictions and its implications for data privacy","authors":"Théo Cavinato, Robin J. Hofmeister, Zoltán Kutalik","doi":"10.1038/s41467-026-78494-w","DOIUrl":"https://doi.org/10.1038/s41467-026-78494-w","url":null,"abstract":"Re-identification by phenotypic prediction aims to determine whether a genome belongs to a specific individual by comparing the individual’s known traits with those predicted from the genome. Although this tracing attack is widely discussed in the genomic privacy literature, its practical risk remains uncertain. As genome-wide association studies (GWAS) continue to improve phenotypic prediction, concerns about the potential for this attack increase.\u0000\u0000Here, to quantify its real-world threat, we develop a probabilistic framework that estimates the likelihood of a match between an individual’s observed traits and polygenic scores (PGS) derived from a genome, while accounting for prediction accuracy and genetic and environmental correlations between traits. We benchmark this re-identification method and examine how the prior probability that a random genome and set of traits correspond to the same person affects performance. Finally, we assess whether sensitive genetic information, such as APOE-ε4 status (linked with Alzheimer’s disease) can be inferred through this attack. Our method outperforms a state-of-the-art tool, reaching a precision above 99% for a recall of 40% when considering a prior of 50%. However, in real-world settings, we estimate that realistic priors do not exceed 4 × 10−4%, resulting in a precision lower than 0.13% at the same recall. Inference of sensitive genetic variants also proves ineffective: precision above 50% for identifying APOE-ε4 carriers is achieved only at a recall below 20%. Thus, although re-identification by phenotypic prediction is technically feasible, its effectiveness in real-world conditions remains limited.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"79 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure and function of cyanobacterial Omp85 reveal Toc159/Toc90 as a chloroplast protein import pore 蓝藻Omp85的结构和功能揭示了Toc159/Toc90是叶绿体蛋白输入孔

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-78967-y

Yu-Sian Wu, Yih-Lin Chen, Yuan-Chih Chang, Chiung-Chih Chu, Chia-Yun Chang, Koichiro Awai, Hsou-min Li

{"title":"Structure and function of cyanobacterial Omp85 reveal Toc159/Toc90 as a chloroplast protein import pore","authors":"Yu-Sian Wu, Yih-Lin Chen, Yuan-Chih Chang, Chiung-Chih Chu, Chia-Yun Chang, Koichiro Awai, Hsou-min Li","doi":"10.1038/s41467-026-78967-y","DOIUrl":"https://doi.org/10.1038/s41467-026-78967-y","url":null,"abstract":"Chloroplast protein-import channel Toc75 evolved from a cyanobacterial outer-membrane Omp85 protein, despite all known Omp85 proteins functioning in export. Chlamydomonas Toc75 assembles with Toc90M, the membrane-spanning domain of Toc90 (equivalent of higher-plant Toc159) into a binocular-shaped complex, but how this architecture arose and functions in import remain unknown. Here, cryo-electron microscopy and mutational analysis of a cyanobacterial Omp85 reveal a lidded 16-β-strand barrel and three POTRA-domains involved in assembling outer-membrane proteins. Structural comparisons show that the Toc75–Toc90M complex mirrors an Omp85–substrate assembly intermediate, and Toc90M can indeed serve as a bacterial Omp85 substrate. While canonical Omp85 systems release substrates after assembly, Toc75 evolved a basic patch in its barrel to anchor Toc90M as a stable lateral pore through which precursor proteins are imported. Our findings indicate that a bacterial export system was converted into a chloroplast import channel by locking a substrate in place to provide an import conduit. This requirement for a stable assembly also supports that additional parts of the ancestral complex, including Omp85 POTRA-domains and Tic236 orthologs, were recruited to facilitate chloroplast protein import.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"21 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergence of diffusion models from associative memory through memorization and generalization 通过记忆和泛化从联想记忆中产生扩散模型

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-78727-y

Bao Pham, Gabriel Raya, Matteo Negri, Mohammed J. Zaki, Luca Ambrogioni, Dmitry Krotov

引用次数: 0

Holographic focused ultrasound enables multitarget EV and MSC delivery for neurovascular repair after ischemic stroke 全息聚焦超声可实现缺血性卒中后神经血管修复的多靶点EV和MSC输送

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-78847-5

Jia-Ji Pan, Chenyu Li, Xinya Yao, Yan Wei, Lan Shen, Xiangkun Piao, Mingyu Wang, Ji Hu, Guo-Yuan Yang, Yanbo Pei, Bingbing Cheng

{"title":"Holographic focused ultrasound enables multitarget EV and MSC delivery for neurovascular repair after ischemic stroke","authors":"Jia-Ji Pan, Chenyu Li, Xinya Yao, Yan Wei, Lan Shen, Xiangkun Piao, Mingyu Wang, Ji Hu, Guo-Yuan Yang, Yanbo Pei, Bingbing Cheng","doi":"10.1038/s41467-026-78847-5","DOIUrl":"https://doi.org/10.1038/s41467-026-78847-5","url":null,"abstract":"Noninvasive multitarget delivery of size-diverse therapeutics, including extracellular vesicles (EVs) and mesenchymal stromal cells (MSCs), to peri-infarct zones is hindered by the blood-brain barrier (BBB) and heterogeneous infarct topographies. Here, we developed a hologram-assisted multitarget BBB opening (HaMBO) platform combining low-cost 3D-printed holograms with a single-element ultrasound transducer. Spatially tailored acoustic fields enabled localized BBB opening along infarct borders. In male mice with transient focal cerebral ischemia, a single two-minute HaMBO treatment safely enhanced the peri-infarct delivery of EVs and MSCs, reduced brain atrophy by ~56%, increased angiogenesis by ~2-fold and neural progenitor proliferation by ~4-fold, and improved long-term behavioral recovery. Spatial transcriptomic analysis associated HaMBO-assisted EV therapy with reduced macrophage infiltration and enhanced pro-angiogenic and neurogenic signaling. Human skull-based simulations further demonstrated HaMBO’s clinical adaptability across diverse stroke scenarios. Thus, HaMBO provides a safe, low-cost, and customizable platform for noninvasive multitarget delivery in ischemic stroke and other neurological disorders.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-point-groups engineering enable multi-ultrahigh-Q resonances via Brillouin zone folding in tetramer metasurfaces 双点群工程通过四聚体超表面的布里渊区折叠实现了多重超高q共振

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-25 DOI: 10.1038/s41467-026-78953-4

Xiao Gu, Yukang Zhang, Shaojun You, Zhenchu Fu, Bo Ni, Jianhua Chang, Haibin Ni, Xiaoshuang Chen, Wei Lu, Guanhai Li, Lujun Huang

{"title":"Dual-point-groups engineering enable multi-ultrahigh-Q resonances via Brillouin zone folding in tetramer metasurfaces","authors":"Xiao Gu, Yukang Zhang, Shaojun You, Zhenchu Fu, Bo Ni, Jianhua Chang, Haibin Ni, Xiaoshuang Chen, Wei Lu, Guanhai Li, Lujun Huang","doi":"10.1038/s41467-026-78953-4","DOIUrl":"https://doi.org/10.1038/s41467-026-78953-4","url":null,"abstract":"High-Q resonances based on bound states in the continuum provide a central route of enhancing light-matter interactions. Here, we present a dual-point group framework of constructing multiple ultrahigh-Q resonances within tetramer metasurfaces with a C4v symmetry via Brillouin zone folding. By selectively preserving or reducing the O- and S-group symmetries of super lattice, guided modes below light cone can be converted into guided resonances or bound states in the continuum with controlled degeneracy lifting, Q-factor scaling, eigenfield profiles, and mode splitting. Besides, applying rectangular lattice provides an alternative way of tuning the Q-factors and mode splitting. Finally, we experimentally demonstrate such two types of high-Q resonances in the tetramer metasurfaces. Measurement results show that the mode splitting can be tuned from 0 nm to 70 nm while the Q-factors are modulated from 300 to 20,000 by varying the asymmetry parameters. This work establishes a symmetry-addressed route for programmable multi-resonant high-Q metasurfaces.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"14 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0