Nature Communications最新文献_第2页

Author Correction: Twinned-magnesium metal negative electrodes enable reversible magnesium electrodeposition.

IF 18.1 1区综合性期刊

Nature Communications Pub Date : 2026-10-19 DOI: 10.1038/s41467-026-78751-y

Guodong Zou, Jingli Ren, Jinming Wang, Yong Sun, Weihao Yang, Tingting Niu, Jinyu Li, Carlos Fernandez, Jean-Jacques Gaumet, Qiuming Peng

引用次数: 0

Controlling the shell growth mechanism and interfacial oxidation of InAs/ZnSe quantum dots for shortwave infrared emission.

IF 18.1 1区综合性期刊

Nature Communications Pub Date : 2026-10-19 DOI: 10.1038/s41467-026-77896-0

Taewan Kim, Manuela De Franco, Miguel Dosil, Jae Taek Oh, Rajesh Bera, Marta Martos Valverde, Gaurav Kumar, Gerasimos Konstantatos

{"title":"Controlling the shell growth mechanism and interfacial oxidation of InAs/ZnSe quantum dots for shortwave infrared emission.","authors":"Taewan Kim, Manuela De Franco, Miguel Dosil, Jae Taek Oh, Rajesh Bera, Marta Martos Valverde, Gaurav Kumar, Gerasimos Konstantatos","doi":"10.1038/s41467-026-77896-0","DOIUrl":"https://doi.org/10.1038/s41467-026-77896-0","url":null,"abstract":"Short-wave infrared (SWIR) emitters underpin applications in communication, imaging and sensing, yet efficient, scalable devices remain limited. Colloidal InAs quantum dots (InAs CQDs) offer a compelling, cost-effective alternative to conventional epitaxial SWIR light-emitting diodes (LEDs). However, developing heavy-metal-free InAs CQDs for emission beyond 1400 nm is hindered by lattice mismatch during core/shell growth, which degrades photoluminescence quantum yield (PLQY). Furthermore, integrating CQDs into LEDs often introduces severe interfacial quenching and intrinsic charge imbalances. Here we report a highly efficient heavy-metal-free SWIR LED operating at 1525 nm, enabled by tailored injection strategies and oxidation-induced interfacial engineering. Optimized high-temperature ZnCl₂ treatment and continuous precursor injection improve shell nucleation and growth, while controlled interfacial oxidation is associated with reduced shell-thickness-dependent strain signatures and improved PLQY retention during shell thickening. Together, these strategies yield measured PLQYs exceeding 55% for emission beyond 1400 nm. Moreover, we demonstrate that incorporating a semiconducting InAs CQD interlayer effectively suppresses interfacial quenching and regulates electron over-injection. Combined with a doped hole-transport layer to reduce series resistance, our optimized devices achieve a maximum external quantum efficiency of 3.5% and a record radiance of ~17 W sr-1 m-2, alongside a T50 operational lifetime of 16 h. Our findings suggest that integrating mechanism-driven shell growth with rational device engineering offers a strategy to overcome current bottlenecks in colloidal emitters, facilitating the transition toward short-wave infrared applications.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"17 1","pages":""},"PeriodicalIF":18.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling.

IF 18.1 1区综合性期刊

Nature Communications Pub Date : 2026-10-19 DOI: 10.1038/s41467-026-78462-4

Yangmengfan Chen, Hao Du, Heng Sun, Xingcan Huang, Duan Wang, Xuming Chen, Jiehao Chen, Xuanjun Zhang, Liqiang Zhou, Zongke Zhou

{"title":"Nano-kinetic implant surface mediates osteo-antibacterial synergy through electromagnetic-mechanical coupling.","authors":"Yangmengfan Chen, Hao Du, Heng Sun, Xingcan Huang, Duan Wang, Xuming Chen, Jiehao Chen, Xuanjun Zhang, Liqiang Zhou, Zongke Zhou","doi":"10.1038/s41467-026-78462-4","DOIUrl":"https://doi.org/10.1038/s41467-026-78462-4","url":null,"abstract":"Periprosthetic joint infection (PJI) is a devastating complication of total joint arthroplasty, mainly caused by bacterial biofilm formation and antibiotic resistance. Traditional static surfaces rely on contact killing-based bactericidal properties and cannot reliably clear mature biofilms. In this study, we fabricate a remote-activated dynamic biomimetic system, namely a movable magnetic topographic surface (MMTS). Here we show that under the exposure of external electromagnetic field (EMF), the anchored Janus nano-heterodimers oscillate periodically to mechanically disrupt bacterial membranes and eradicates biofilms of Staphylococcus aureus and Escherichia coli. This mechanical force can also activates Piezo1 mechanosensitive ion channel in bone marrow mesenchymal stem cells (BMSCs), inducing calcium oscillations, upregulating gene expression of Runx2 and BMP2, and enhancing extracellular matrix mineralization. In vivo, MMTS combined with EMF exposure eliminates local infection and promoted osseointegration. This remote-activated dynamic biomimetic strategy offers a promising multifunctional platform for PJI treatment, and improved implant osteointegration in clinical orthopedics.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"17 1","pages":""},"PeriodicalIF":18.1,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular architecture of Cryptococcus cell walls reveals species-specific chitosan-dependent remodeling 隐球菌细胞壁的分子结构揭示了物种特异性壳聚糖依赖性重塑

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-18 DOI: 10.1038/s41467-026-78940-9

Ankur Ankur,Rajendra Upadhya,Mahsa Doosti,Davis Ferreira,Sara E. Miller,Li Xie,Ivan Hung,Jennifer K. Lodge,Tuo Wang

{"title":"Molecular architecture of Cryptococcus cell walls reveals species-specific chitosan-dependent remodeling","authors":"Ankur Ankur,Rajendra Upadhya,Mahsa Doosti,Davis Ferreira,Sara E. Miller,Li Xie,Ivan Hung,Jennifer K. Lodge,Tuo Wang","doi":"10.1038/s41467-026-78940-9","DOIUrl":"https://doi.org/10.1038/s41467-026-78940-9","url":null,"abstract":"Abstract Cryptococcus neoformans and Cryptococcus gattii are fungal pathogens that cause life-threatening infections, including cryptococcal meningitis. A distinctive feature of the cryptococcal cell wall is the extensive deacetylation of chitin to chitosan, a modification that is essential for virulence but whose structural role in cell-wall organization remains poorly understood. Here, we analyze the cell walls of wild-type strains of both species and their avirulent chitosan-deficient mutants, which serve as vaccine candidates. Loss of chitosan disrupted cell morphology and altered cell-wall ultrastructure, with more pronounced defects in C. neoformans . Solid-state NMR reveals that aggregated α-(1→3)-glucans form the principal rigid domain of the cell wall in both species and are closely associated with chitin microfibrils, whereas surrounding β-glucans and mannoproteins constitute a more dynamic matrix. Chitosan modulates hydration and flexibility, and its loss increases chitin exposure and triggers species-specific remodeling of the polysaccharide network. In C. neoformans , chitosan depletion increased α-(1→3)-glucan content and reduced β-glucan levels, whereas C. gattii selectively lost one α-(1→3)-glucan subtype while maintaining β-glucan levels. Although capsule production remained intact, chitosan deficiency altered glucuronoxylomannan linkage patterns and mannoprotein composition. These findings reveal how chitosan organizes cryptococcal cell-wall architecture and highlight distinct structural adaptation strategies among pathogenic Cryptococcus species.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"2 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solvent heterogeneity regulates assembly pathways in supramolecular polymerization 溶剂非均质性调节超分子聚合的组装途径

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-18 DOI: 10.1038/s41467-026-78525-6

Goutam Ghosh,Jim Bachmann,Marvin Nyenhuis,Timo Krüger,Zulema Fernández,João Paulo Coelho,Antonia Albers,Max Köyer,Nikos Doltsinis,Gustavo Fernández

{"title":"Solvent heterogeneity regulates assembly pathways in supramolecular polymerization","authors":"Goutam Ghosh,Jim Bachmann,Marvin Nyenhuis,Timo Krüger,Zulema Fernández,João Paulo Coelho,Antonia Albers,Max Köyer,Nikos Doltsinis,Gustavo Fernández","doi":"10.1038/s41467-026-78525-6","DOIUrl":"https://doi.org/10.1038/s41467-026-78525-6","url":null,"abstract":"Abstract Supramolecular polymers are fundamental mimics of biological assemblies with diverse functions. However, predicting monomer solubility and controlling the colloidal stability of the resulting assemblies in solution remain major challenges. As a result, their preparation commonly relies on solvent mixtures, which can generate local heterogeneities during sample processing—an effect that remains poorly understood. Here, we demonstrate that solvent heterogeneity biases assembly pathways in supramolecular polymerization, with the extent of this effect modulated by monomer structure. Using an amphiphilic Pd(II) complex as a model system, we uncover a thermally accelerated transition from kinetically controlled discrete nanostructures to thermodynamically stable supramolecular polymers in water/1,4-dioxane mixtures. Combined experimental and theoretical analyses reveal that this transformation is mediated by microscopic liquid–liquid phase separation within the mixed solvent, creating 1,4-dioxane-enriched microdomains with increased local monomer concentration. Thermal annealing enhances molecular mobility and promotes the growth and coalescence of these microdomains, facilitating the transition to one-dimensional fibers. Extending the investigation to structurally related monomers further identifies the metal center and hydrogen-bonding motifs as key design elements governing this behavior. By linking molecular design and solvent heterogeneity to pathway complexity, our findings highlight how mixed solvents can be used to control supramolecular polymerization.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"11 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteroides–Escherichia interactions contribute to colonization resistance against Clostridioides difficile 拟杆菌-埃希氏菌相互作用有助于对艰难梭菌的定植抗性

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-18 DOI: 10.1038/s41467-026-78132-5

Achuthan Ambat,Naomi Iris van den Berg,Francisco Zorrilla,Shruti Menon,Abhijit Maji,Tanim Islam,Arianna Basile,Sudeep Ghimire,Lajos Kalmar,Kiran R. Patil,Joy Scaria

{"title":"Bacteroides–Escherichia interactions contribute to colonization resistance against Clostridioides difficile","authors":"Achuthan Ambat,Naomi Iris van den Berg,Francisco Zorrilla,Shruti Menon,Abhijit Maji,Tanim Islam,Arianna Basile,Sudeep Ghimire,Lajos Kalmar,Kiran R. Patil,Joy Scaria","doi":"10.1038/s41467-026-78132-5","DOIUrl":"https://doi.org/10.1038/s41467-026-78132-5","url":null,"abstract":"Abstract Commensal gut bacteria are key contributors to the resilience against pathogen invasion. This is exemplified by the success of faecal microbiota transplantation in treating recurrent Clostridioides difficile infection. Yet, characteristics of communities that can confer colonisation resistance and the underlying mechanisms remain largely unknown. Here we use a synthetic community of 14 commensal gut bacteria to uncover inter-species interactions and metabolic pathways underpinning the emergent resilience against C. difficile invasion. We challenged this synthetic community as well as faecal-matter-derived communities with antibiotic treatment and C. difficile in a continuous flow bioreactor. Using generalised Lotka-Volterra and genome-scale metabolic modelling, we identified interactions between Escherichia coli and Bacteroides/Phocaeicola sp. as key to the pathogen’s suppression. Metabolomics and targeted validation experiments revealed that fructan-derived fructooligosaccharides, vitamin B3 biosynthesis, and competition for Stickland metabolism precursors causally contribute to suppression across multiple C. difficile strains and donor backgrounds. Analysis of metagenomics data from patient cohorts and clinical trials attested the in vivo relevance of the identified metabolic pathways and the ratio between Bacteroides and Escherichia in successful colonisation resistance. The latter was found to be a stronger discriminator than commonly used alpha diversity metrics. Together, our study uncovers emergent microbial interactions in pathogen resistance with implications for rational design of bacteriotherapies.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"412 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enantioselective sp3-sp3 cross-coupling of oxygen-containing heterocycles with cyclopropanols 含氧杂环与环丙醇的对映选择性sp3-sp3交叉偶联

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-17 DOI: 10.1038/s41467-026-78834-w

Yang Ke,Huiyao Liu,Gaoyuan Yu,Yuanyuan Ping,Wangqing Kong

引用次数: 0

Adma and Ackr3a regulate cardiac lymphatic vessel formation and function during heart development and regeneration Adma和Ackr3a在心脏发育和再生过程中调节心脏淋巴管的形成和功能

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-17 DOI: 10.1038/s41467-026-78353-8

Xidi Feng,Hui-Yu Chen,Yuhan Sun,Fei Sun,Sean Yan,Subir Kapuria,Raquel Rodriguez,Laurent Gamba,J. Gage Crump,Young-Kwon Hong,Kenneth D. Poss,Ching-Ling Lien

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Optical-handedness-driven enantioselective synthesis and programmable chirality encoding of covalent organic frameworks 光学手性驱动的共价有机骨架的对映选择合成和可编程手性编码

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-17 DOI: 10.1038/s41467-026-78524-7

Taewoong Kim,Jaewon Kim,Joohee Oh,Seungyoon Kang,Song Gyun Kim,Jee Hyeon Kim,Min Su Han,Young Yong Kim,Chanho Pak,Jeong-Eun Park,Hyunseob Lim

引用次数: 0

Breaking water-structure constraints by Hofmeister effects in interfacial polymerization for polyamide membranes 聚酰胺膜界面聚合中利用Hofmeister效应打破水结构约束

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-17 DOI: 10.1038/s41467-026-78649-9

Qingchen Tang,Hao Chen,Yu Chen,Hanyu Wu,Xingwang Meng,Wu Jin,Panjia Jiang,Yizhou Zhang,Xunda Feng

{"title":"Breaking water-structure constraints by Hofmeister effects in interfacial polymerization for polyamide membranes","authors":"Qingchen Tang,Hao Chen,Yu Chen,Hanyu Wu,Xingwang Meng,Wu Jin,Panjia Jiang,Yizhou Zhang,Xunda Feng","doi":"10.1038/s41467-026-78649-9","DOIUrl":"https://doi.org/10.1038/s41467-026-78649-9","url":null,"abstract":"Abstract Hydration critically governs the physicochemical behavior of solutes in both the aqueous bulk and interfacial environments. As typical chaotropic Hofmeister ions, weakly hydrated anions (WHAs) can reshape hydration structures and accumulate at water–hydrophobe interfaces. Notably, WHAs paradoxically suppress the solubility of certain small-molecule monomers in water while enhancing that of chemically analogous polymers. Here, we exploit WHA-mediated Hofmeister hydration control to regulate polyamide-forming interfacial polymerization (IP), using the piperazine (PIP) and trimesoyl chloride (TMC) nanofiltration system as the primary model. Introducing WHAs into the aqueous phase reduces the affinity of amine monomers for water and accelerates partitioning into the reaction front in the oil phase, remarkably reinforcing IP self-limitation. Simultaneously, interfacial WHA enrichment lowers interfacial tension and, together with accelerated amine delivery, potentially intensifies transport-driven interfacial instabilities. WHAs also lower interfacial water availability, attenuating acyl chloride hydrolysis. These synergistic effects yield hollow-ridged polyamide selective layers with reduced thickness and high crosslinking density, delivering enhanced water permeance and salt rejection. Crucially, module-scale fabrication of high-performance membranes demonstrates that WHA-mediated Hofmeister hydration control is directly compatible with established desalination pipelines.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"26 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0