Nature Communications最新文献_第2页

Disrupting sympathetic nerve-tumor crosstalk via biomimetic nanovesicles to augment chemotherapy efficacy under chronic stress. 通过仿生纳米囊破坏交感神经肿瘤串扰增强慢性应激下化疗疗效。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72847-1

Jingjie Liu, Jiaqi Qin, Wenxia Zheng, Xiaojuan Wang, Zhaohan Wei, Zixiang Xie, Tingwei Yan, Xin Li, Ziqiao Ding, Haojie Liu, Zhiheng Cai, Shanmiao Gou, Xiangliang Yang, Tuying Yong, Lu Gan

{"title":"Disrupting sympathetic nerve-tumor crosstalk via biomimetic nanovesicles to augment chemotherapy efficacy under chronic stress.","authors":"Jingjie Liu, Jiaqi Qin, Wenxia Zheng, Xiaojuan Wang, Zhaohan Wei, Zixiang Xie, Tingwei Yan, Xin Li, Ziqiao Ding, Haojie Liu, Zhiheng Cai, Shanmiao Gou, Xiangliang Yang, Tuying Yong, Lu Gan","doi":"10.1038/s41467-026-72847-1","DOIUrl":"https://doi.org/10.1038/s41467-026-72847-1","url":null,"abstract":"Chronic stress significantly impacts cancer progression by activating the sympathetic nervous system, leading to increased tumor growth, metastasis, and resistance to chemotherapy. To address these challenges, we develop biomimetic hybrid nanovesicles (Pro@hNVs) by fusing M1 macrophage-derived vesicles with pH-sensitive liposomes (hNVs) to encapsulate the β-adrenergic receptor (ADRB) blocker propranolol (Pro). Leveraging the tumor-targeting properties of M1 macrophage-derived vesicles and their matrix metalloproteinase-mediated degradation of tumor extracellular matrix, Pro@hNVs effectively accumulate and deeply penetrate tumor tissues, followed by the release of Pro in response to the acidic tumor microenvironment. Pro subsequently inhibits the sympathetic nerve-cancer cell crosstalk by blocking ADRB2 signaling. Meanwhile, Pro@hNVs effectively reprogram adrenergic signal-induced M2-like tumor-associated macrophages (TAMs) into the M1 phenotype through the released Pro and hNVs, thereby amplifying TNF-mediated neurotoxicity and effectively disrupting sympathetic nerve-macrophage crosstalk. This dual-action mechanism of Pro@hNVs significantly inhibits the sympathetic nerve function promoted by gemcitabine, resulting in the improved chemotherapy efficacy and enhanced antitumor immune response under chronic stress. These findings highlight the potential of Pro@hNVs as a promising strategy to enhance chemotherapy outcomes in cancer patients experiencing chronic stress, offering a viable therapeutic avenue for overcoming treatment resistance.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporality modulates the effect of network heterogeneity on cooperation fixation. 时间性调节网络异质性对合作固定性的影响。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72717-w

Aming Li, Yao Meng, Lei Zhou, Naoki Masuda, Long Wang

{"title":"Temporality modulates the effect of network heterogeneity on cooperation fixation.","authors":"Aming Li, Yao Meng, Lei Zhou, Naoki Masuda, Long Wang","doi":"10.1038/s41467-026-72717-w","DOIUrl":"https://doi.org/10.1038/s41467-026-72717-w","url":null,"abstract":"Understanding the evolution of cooperation in structured populations remains a central challenge in multidisciplinary areas. Although previous findings suggest that structural heterogeneity in static networks hinders cooperation, real-world interactions in most natural and social systems are dynamic and best represented as temporal networks. Here, we challenge this conventional wisdom and, by developing a systematic mathematical framework, we report that structural heterogeneity in temporal networks can instead promote collective cooperation. Importantly, we reveal that such advantages depend on an often-overlooked metric-fixation time-quantifying the time required for a single cooperator to drive the entire population to cooperation. Highly heterogeneous networks accelerate this process within each subnetwork, resulting in a quantitative enhancement of cooperation in temporal networks compared to their homogeneous counterparts. By validating our results on empirical datasets through theoretical analyses and simulations, we provide a consistent framework for analysing cooperative dynamics across static and temporal networked systems.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZAT-DNA enables DNA data storage with molecular-layer non-replicability. ZAT-DNA使DNA数据存储具有分子层不可复制性。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72869-9

Lifu Song, Gaoli Wang, Yifeng Wei, Yingjie Huang, Yunkun Zhang, Xuesong Liu, Zhiguang Yuchi, Yingjin Yuan, Yunzi Luo, Yan Zhang

{"title":"ZAT-DNA enables DNA data storage with molecular-layer non-replicability.","authors":"Lifu Song, Gaoli Wang, Yifeng Wei, Yingjie Huang, Yunkun Zhang, Xuesong Liu, Zhiguang Yuchi, Yingjin Yuan, Yunzi Luo, Yan Zhang","doi":"10.1038/s41467-026-72869-9","DOIUrl":"https://doi.org/10.1038/s41467-026-72869-9","url":null,"abstract":"Deoxyribonucleic acid provides unmatched information density and longevity for data storage, yet its easy amplification by polymerase chain reaction enables unauthorized replication at negligible cost. We introduce ZAT-DNA, which encodes information in patterns of canonical adenine and noncanonical 2-aminoadenine. As DNA polymerases cannot distinguish adenine from 2-aminoadenine, polymerase-based amplification erases these patterns, enforcing molecular-layer non-replicability intrinsic to the base-pairing ambiguity. We validate ZAT-DNA for secure key storage, demonstrating error-free encoding, storage, and high-fidelity nanopore retrieval of 32-bit and 64-bit cryptographic keys. ZAT-DNA blocks polymerase-based copying and protects non-fungible tokens by preventing functional duplication. For larger datasets, we present a hybrid \"Babel-DNA\" architecture: multiple encrypted images are co-encoded in a single regular DNA pool, with each selectively decryptable only via its cognate, non-replicable ZAT-DNA key. This provides a practical framework for molecular access control, secure DNA-encoded databases, and scarce molecular tokens.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CLASHub is an integrated database and analytical platform for microRNA-target interactions. CLASHub是microrna -靶标相互作用的集成数据库和分析平台。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72902-x

Lu Li, Peike Sheng, Nicholas M Hiers, Tianqi Li, Acadia L Grimme, Yuzhi Wang, Conner M Traugot, Olivia M D'Agati, Mingyi Xie

{"title":"CLASHub is an integrated database and analytical platform for microRNA-target interactions.","authors":"Lu Li, Peike Sheng, Nicholas M Hiers, Tianqi Li, Acadia L Grimme, Yuzhi Wang, Conner M Traugot, Olivia M D'Agati, Mingyi Xie","doi":"10.1038/s41467-026-72902-x","DOIUrl":"https://doi.org/10.1038/s41467-026-72902-x","url":null,"abstract":"MicroRNAs (miRNAs) are short RNAs that regulate gene expression, critical for development and disease. Residing in Argonaute (AGO) proteins, miRNAs target messenger RNAs via complementary base-pairing. Current miRNA-target databases rely on indirect data from AGO crosslinking immunoprecipitation (AGO-CLIP). In contrast, CLASH (Crosslinking, Ligation, and Sequencing of Hybrids) employs proximity ligation within AGO complexes, providing direct miRNA-target interaction evidence. Existing CLASH datasets remain limited to a few human and mouse samples. Here, we present CLASHub, which integrates CLASH-defined interactions with gene and miRNA expression data from human, mouse, Drosophila, and C. elegans, spanning 25 cell types and tissues, including 91 new CLASH datasets generated from 17 cell types/tissues. The datasets also include samples with knockout of ZSWIM8, an essential component in target-directed miRNA degradation (TDMD), providing insights into miRNA turnover mechanisms. CLASHub features a user-friendly Analyzer interface for CLASH, RNA-seq, miRNA-seq, and cumulative fraction curve analyses. Leveraging these tools, we uncover a TDMD trigger in the ATP6V1G1 3' UTR for miR-335-3p degradation, as well as multiple targets of miR-18a-5p. Thus, CLASHub is an online platform that enables cell/tissue-specific exploration of miRNA-target interactions, supporting miRNA and broader RNA biology research. The platform is publicly accessible at https://clashub.rc.ufl.edu/.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell-free DNA size deconvolution resolves nucleosomal origins and reveals tumor-associated fragmentomic alterations. 无细胞DNA大小反褶积解决核小体起源和揭示肿瘤相关的片段组改变。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72925-4

Ze Zhou, Wendy N Cooper, Zhao Cheng, Sara Lightowlers, Charlotte E Coles, Amit Roshan, Nitzan Rosenfeld, Hui Zhao

{"title":"Cell-free DNA size deconvolution resolves nucleosomal origins and reveals tumor-associated fragmentomic alterations.","authors":"Ze Zhou, Wendy N Cooper, Zhao Cheng, Sara Lightowlers, Charlotte E Coles, Amit Roshan, Nitzan Rosenfeld, Hui Zhao","doi":"10.1038/s41467-026-72925-4","DOIUrl":"https://doi.org/10.1038/s41467-026-72925-4","url":null,"abstract":"Analysis of cell-free DNA (cfDNA) fragmentomic features holds great promise for minimally invasive cancer diagnostics. Although selectively analyzing short plasma cfDNA enriches tumor-derived DNA (ctDNA), the mechanisms shaping cfDNA size profiles remain incompletely understood. Here, we develop a generalized model of cfDNA fragment length distributions across multiple bodily fluids (saliva, urine, cerebrospinal fluid, lymphatic fluid, and plasma), deconvoluting size profiles into ~10-bp periodic peaks (components), each approximated by a Cauchy-Lorentz distribution. This analytical framework enables investigation of cfDNA fragmentation across diverse pathological states and reveals a 159-bp component that may demarcate intra- and inter-nucleosomal cfDNA. By analyzing plasma DNA from individuals harboring germline TP53 mutations, patients receiving radiotherapy, and liver transplantation recipients, we demonstrate that ctDNA shortening can be distinguished from phagocytosis-associated cfDNA shortening through differences in the amplitude and scale parameters of intra- and inter-nucleosomal components. Moreover, leveraging tumor-related fragmentomic alterations, characterized by increased fragmentation entropy identified through cfDNA size deconvolution, significantly enhances cancer detection.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noncovalent synthesis of higher-order super-heterostructures from structurally distinct molecular π-systems via secondary nucleation. 从结构不同的分子π体系中通过二次成核非共价合成高阶超异质结构。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72700-5

Sai Rachana Pramatha, Girada Narendra Kumar, Kotagiri Venkata Rao

{"title":"Noncovalent synthesis of higher-order super-heterostructures from structurally distinct molecular π-systems via secondary nucleation.","authors":"Sai Rachana Pramatha, Girada Narendra Kumar, Kotagiri Venkata Rao","doi":"10.1038/s41467-026-72700-5","DOIUrl":"https://doi.org/10.1038/s41467-026-72700-5","url":null,"abstract":"Noncovalently connecting supramolecular assemblies of structurally distinct π-systems to result in higher-order heterostructures is a grand challenge due to the problem of phase segregation into individual components. Although a few supramolecular heterostructures were recently reported, they are based on molecular π-systems with minimal structural differences. In this study, we demonstrate a rational approach to construct fully supramolecular bicomponent higher-order super-heterostructures such as fibers-reinforced two-dimensional nanoplatelet clusters using structurally distinct π-systems. We have achieved this using near-infrared absorbing tetraimide dye and perylene diimide as the building blocks. Here, perylene diimide acts as a source of dormant monomers, and the self-assembled structures of the tetraimide dye serve as the seeds. Interestingly, tetraimide dye self-assemble into two-dimensional nanoplatelet clusters with switchable hierarchy in dimethyl sulfoxide. When the dormant monomers of perylene diimide are added to the tetraimide seeds, nucleation occurs on the surface of the two-dimensional nanoplatelets of the clusters, and their switchable hierarchy allowed us to synthesize two types of corresponding super-heterostructures selectively. Our investigations further reveal that secondary nucleation and dispersive interactions guide the formation of these super-heterostructures.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid-derived, solvent-free vapor-mediated dimensional reconstruction yields a record fill factor in inverted perovskite solar cells. 液体衍生的，无溶剂的蒸汽介导的尺寸重建产生了一个记录填充因子在倒置钙钛矿太阳能电池。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72790-1

Yinjiang Liu, Tengfei Kong, Zihan Zhao, Weiting Chen, Qili Song, Wenjie Liang, Dongqin Bi

{"title":"Liquid-derived, solvent-free vapor-mediated dimensional reconstruction yields a record fill factor in inverted perovskite solar cells.","authors":"Yinjiang Liu, Tengfei Kong, Zihan Zhao, Weiting Chen, Qili Song, Wenjie Liang, Dongqin Bi","doi":"10.1038/s41467-026-72790-1","DOIUrl":"https://doi.org/10.1038/s41467-026-72790-1","url":null,"abstract":"Despite recent advances, the fill factor (FF) of perovskite solar cells remains limited, largely owing to defect-related recombination. Paradoxically, most defect passivation approaches still depend on solvents, which deteriorate stability and pose challenges for large-scale fabrication. Here, we introduce a vapor-phase deposited from a liquid triethylammonium pentafluoropropionate (TEA-PFP) layer on top of perovskite. During deposition, TEA⁺ reacts with residual PbI2 to generate a one-dimensional TEAPbI3 interfacial phase, promoting continuous electronic coupling and facilitating charge extraction. Simultaneously, the Lewis-basic PFP- anion passivates under-coordinated Pb2+ and suppresses vacancy formation, markedly reducing non-radiative recombination. The bulky TEA+ and strongly dipolar PFP- groups anchor at surface Pb sites, forming a self-limited, surface-confined layer. As a result, we achieve a champion power conversion efficiency of 26.71% (certified 26.15%) and a record FF = 89.13% for small area device, while attaining a PCE of 25.32% for 1 cm2 device. Moreover, this strategy effectively mitigates Ag+ diffusion during accelerated aging and preserves outstanding stability under combined thermal and humidity stress, providing a robust pathway to overcome the FF bottleneck in perovskite photovoltaics.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous orthogonal cell engineering by a single CRISPR-Cas9 polyfunctional editor. 通过单个CRISPR-Cas9多功能编辑器同时进行正交细胞工程。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72846-2

Deborah Cipria, Tania Baccega, Miriana Rizzo, Piergiuseppe Quarato, Alice Reschigna, Rita El Khoury, Martino Alfredo Cappelluti, Sandra Ammann, Valeria Mollica Poeta, Matteo Conti, Sara Valsoni, Pietro Spinelli, Ivan Merelli, Toni Cathomen, Monica Casucci, Angelo Lombardo

{"title":"Simultaneous orthogonal cell engineering by a single CRISPR-Cas9 polyfunctional editor.","authors":"Deborah Cipria, Tania Baccega, Miriana Rizzo, Piergiuseppe Quarato, Alice Reschigna, Rita El Khoury, Martino Alfredo Cappelluti, Sandra Ammann, Valeria Mollica Poeta, Matteo Conti, Sara Valsoni, Pietro Spinelli, Ivan Merelli, Toni Cathomen, Monica Casucci, Angelo Lombardo","doi":"10.1038/s41467-026-72846-2","DOIUrl":"https://doi.org/10.1038/s41467-026-72846-2","url":null,"abstract":"The parallel disruption of multiple genes coupled with targeted transgene insertion offers a powerful strategy for more effective and precise cell engineering. However, such orthogonal editing involves the induction of multiple DNA breaks, raising safety concerns related to the risks of chromosomal translocations. Here, we present a polyfunctional CRISPR-Cas9-based strategy that enables both transgene insertion and epigenetic silencing at distinct genomic loci in a single treatment without inducing reciprocal chromosomal translocations. This is accomplished through an optimized all-in-one epigenome editor equipped with a catalytically active Cas9, whose endonuclease activity is selectively disabled at epigenetically silenced loci using truncated gRNAs. As a proof of concept, we demonstrate that this platform enables efficient multi-locus editing, including functional replacement of the endogenous TCR with a tumor-selective one, targeted insertion of a prototypic CAR with either a selectable marker or an immunomodulatory receptor into a TCR locus or a ubiquitously expressed gene, and durable, multiplexed epigenetic silencing of clinically relevant genes in primary human T cells. Polyfunctional editing establishes a versatile and safe framework for orthogonal editing, broadening the scope of genome and epigenome engineering in cancer immunotherapy and beyond.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energy-efficient field-free switching by orbital torque and spin-reorientation. 基于轨道转矩和自旋重定向的节能无场开关。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72894-8

Bilal Jamshed, Subhakanta Das, Pinkesh Kumar Mishra, Wai Lum William Mah, Mathias Kläui, S N Piramanayagam

{"title":"Energy-efficient field-free switching by orbital torque and spin-reorientation.","authors":"Bilal Jamshed, Subhakanta Das, Pinkesh Kumar Mishra, Wai Lum William Mah, Mathias Kläui, S N Piramanayagam","doi":"10.1038/s41467-026-72894-8","DOIUrl":"https://doi.org/10.1038/s41467-026-72894-8","url":null,"abstract":"Spin-orbit torque has emerged as a leading strategy for low-power magnetisation switching in modern spintronics. To date, most efforts have focused on boosting spin currents via the spin Hall effect, exploiting only the electron's spin while largely ignoring its orbital angular momentum. Meanwhile, deterministic switching of perpendicular magnetic anisotropy layers typically requires an external in-plane field to break inversion symmetry, adding power overhead and hindering large-scale deployment. Here, we demonstrate energy-efficient field-free magnetisation switching enabled by spin reorientation in a synthetic antiferromagnetic structure and enhanced by orbital torque. By tuning the exchange coupling field and magnetic anisotropy of the synthetic antiferromagnetic samples, we achieved a magnetisation switching of 96% utilising both spin and orbital torque. Furthermore, increasing the orbital Hall layer thickness by 15 nm leads to an 85% enhancement of damping-like torque efficiency compared to the reference sample with a Pt layer as the spin source. These results demonstrate orbital angular momentum transport as an efficient torque-generation mechanism in synthetic antiferromagnetic heterostructures, offering a scalable route toward low-power spintronic devices.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD84 is a specific target for acute myeloid leukemia CAR-T cell therapy. CD84是急性髓系白血病CAR-T细胞治疗的特异性靶点。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72361-4

Martina Pigazzi, Silvia Merlini, Ambra Da Ros, Olivia Marini, Giovanni Faggin, Nicolò Fortuna, Raffaele Mattera, Barbara Buldini, Paolo Rizzardi, Soheil Meshinchi, Giuseppe Basso, Franco Locatelli, Alessandra Biffi

{"title":"CD84 is a specific target for acute myeloid leukemia CAR-T cell therapy.","authors":"Martina Pigazzi, Silvia Merlini, Ambra Da Ros, Olivia Marini, Giovanni Faggin, Nicolò Fortuna, Raffaele Mattera, Barbara Buldini, Paolo Rizzardi, Soheil Meshinchi, Giuseppe Basso, Franco Locatelli, Alessandra Biffi","doi":"10.1038/s41467-026-72361-4","DOIUrl":"https://doi.org/10.1038/s41467-026-72361-4","url":null,"abstract":"Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment of hematologic malignancies, yet its application to acute myeloid leukemia (AML) remains challenging due to the scarcity of disease-specific antigens. The identification of a highly selective target is crucial to enhance efficacy while minimizing off-tumor toxicity. Here, we identify CD84 as a promising target for AML immunotherapy, displaying a unique expression profile: it is robustly and stably expressed by blasts, particularly in relapsed disease, and negligible on normal hematopoietic stem/progenitor cells. This profile renders CD84 an ideal target, with potential for improved therapeutic precision and potency, and with reduced risk of off-target effects and toxicity. To assess its potential, we generate CD84-directed CAR-T cells and test them in vitro and in vivo on clinically relevant models. The engineered cells exhibit potent cytotoxicity against CD84-expressing AML cell lines and patient-derived xenograft (PDX) cells, eliminating leukemic blasts even with low CD84 expression. In AML-PDX models, CAR-T treatment leads to sustained reduction of leukemia burden, doubling the survival of the treated animals compared to controls. No downregulation of CD84 expression on the blasts in the treated models is seen. Importantly, CD84 CAR-T cells spare normal hematopoietic stem/progenitor cells that after treatment retain their repopulation potential in humanized models. These findings establish CD84 as a target for AML immunotherapy and provide a compelling rationale for clinical development of CD84-directed approaches that may address an urgent need for treatment in aggressive and refractory AML.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0