Nature Communications最新文献_第2页

Analysis of NS2-dependent effects on influenza PB1 segment extends replication requirements beyond the canonical promoter

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-22 DOI: 10.1038/s41467-025-57092-2

Sharmada Swaminath, Marisa Mendes, Yipeng Zhang, Kaleigh A. Remick, Isabel Mejia, Melissa Güereca, Aartjan J. W. te Velthuis, Alistair B. Russell

{"title":"Analysis of NS2-dependent effects on influenza PB1 segment extends replication requirements beyond the canonical promoter","authors":"Sharmada Swaminath, Marisa Mendes, Yipeng Zhang, Kaleigh A. Remick, Isabel Mejia, Melissa Güereca, Aartjan J. W. te Velthuis, Alistair B. Russell","doi":"10.1038/s41467-025-57092-2","DOIUrl":"https://doi.org/10.1038/s41467-025-57092-2","url":null,"abstract":"Influenza A virus encodes conserved promoter sequences. Using minimal replication assays—transfections with viral polymerase, nucleoprotein, and a genomic template—these sequences were identified as 13nt at the 5’ end of the genomic RNA (U13) and 12nt at the 3’ end (U12). Other than the fourth 3’ nucleotide, the U12 and U13 sequences are identical between all eight RNA molecules of the segmented influenza A genome. However, individual segments can exhibit different dynamics during infection. Influenza NS2, which modulates transcription and replication differentially between genomic segments, may provide an explanation. Here, we assess how internal sequences of two genomic segments, HA and PB1, contribute to NS2-dependent replication and map such interactions down to individual nucleotides in PB1. We find that the expression of NS2 significantly alters sequence requirements for efficient replication beyond the identical U12 and U13 sequences, providing a potential mechanism for segment-specific replication dynamics across the influenza genome.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"209 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational design of precatalysts and controlled evolution of catalyst-electrolyte interface for efficient hydrogen production

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-22 DOI: 10.1038/s41467-025-57056-6

Anquan Zhu, Lulu Qiao, Kai Liu, Guoqiang Gan, Chuhao Luan, Dewu Lin, Yin Zhou, Shuyu Bu, Tian Zhang, Kunlun Liu, Tianyi Song, Heng Liu, Hao Li, Guo Hong, Wenjun Zhang

{"title":"Rational design of precatalysts and controlled evolution of catalyst-electrolyte interface for efficient hydrogen production","authors":"Anquan Zhu, Lulu Qiao, Kai Liu, Guoqiang Gan, Chuhao Luan, Dewu Lin, Yin Zhou, Shuyu Bu, Tian Zhang, Kunlun Liu, Tianyi Song, Heng Liu, Hao Li, Guo Hong, Wenjun Zhang","doi":"10.1038/s41467-025-57056-6","DOIUrl":"https://doi.org/10.1038/s41467-025-57056-6","url":null,"abstract":"The concept of precatalyst is widely accepted in electrochemical water splitting, but the role of precatalyst activation and the resulted changes of electrolyte composition is often overlooked. Here, we elucidate the impact of potential-dependent changes for both precatalyst and electrolyte using Co2Mo3O8 as a model system. Potential-dependent reconstruction of Co2Mo3O8 precatalyst results in an electrochemically stable Co(OH)2@Co2Mo3O8 catalyst and additional Mo dissolved as MoO42− into electrolyte. The Co(OH)2/Co2Mo3O8 interface accelerates the Volmer reaction and negative potentials induced Mo2O72− (from MoO42−) further enhances proton adsorption and H2 desorption. Leveraging these insights, the well-designed MoO42−/Mo2O72− modified Co(OH)2@Co2Mo3O8 catalyst achieves a Faradaic efficiency of 99.9% and a yield of 1.85 mol h−1 at −0.4 V versus reversible hydrogen electrode (RHE) for hydrogen generation. Moreover, it maintains stable over one month at approximately 100 mA cm−2, highlighting its industrial suitability. This work underscores the significance of understanding on precatalyst reconstruction and electrolyte evolution in catalyst design.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"65 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying signatures of past and present cryovolcanism on Europa

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-22 DOI: 10.1038/s41467-025-57070-8

Elodie Lesage, Samuel M. Howell, Marc Neveu, Julia W. Miller, Mariam Naseem, Mohit Melwani Daswani, Justine Villette, Steven D. Vance

引用次数: 0

EccDNA atlas in male mice reveals features protecting genes against transcription-induced eccDNA formation

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-22 DOI: 10.1038/s41467-025-57042-y

Xue Liang, Gerard Arrey, Yating Qin, Lucía Álvarez-González, Judith Mary Hariprakash, Jie Ma, Sylvester Holt, Peng Han, Yonglun Luo, Hanbo Li, Aurora Ruiz-Herrera, Henriette Pilegaard, Birgitte Regenberg

引用次数: 0

Cold spells over Greenland during the mid-Pliocene Warm Period

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-22 DOI: 10.1038/s41467-025-56996-3

I. M. C. Sousa, C. Hillaire-Marcel, A. de Vernal, J. -C. Montero-Serrano, A. M. R. Aubry

{"title":"Cold spells over Greenland during the mid-Pliocene Warm Period","authors":"I. M. C. Sousa, C. Hillaire-Marcel, A. de Vernal, J. -C. Montero-Serrano, A. M. R. Aubry","doi":"10.1038/s41467-025-56996-3","DOIUrl":"https://doi.org/10.1038/s41467-025-56996-3","url":null,"abstract":"The mid-Pliocene Warm Period (mPWP; 3.26–3.02 Ma) is an interval often suggested as a potential analogue of the near future climate and fate of the Greenland Ice Sheet (GIS). Here, neodymium and lead isotopes from marine sediment cores collected off the southern Greenland margin suggest pulses of intense glacial erosion of Precambrian terranes during this interval, while grain size data indicate a reduction in the strength of contour currents, both following a near obliquity cycle (~41 ka) pacing. These cold spells were thus sufficiently intense to trigger recurrent ice growth over Greenland, even under the high atmospheric CO2 concentration (~400 ppmV) of the interval, before the intensification of the Northern Hemisphere Glaciation (~2.7 Ma). However, the mPWP was marked by a low amplitude in the axial tilt oscillation of the Earth, thus lesser variations in summer insolation at high latitudes than in the present era. Therefore, although it may offer some similarities with the future of the Earth’s climate, the mid-Pliocene cannot be seen as a genuine analogue for predicting the fate of the GIS.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"89 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpretable single-cell factor decomposition using sciRED

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-22 DOI: 10.1038/s41467-025-57157-2

Delaram Pouyabahar, Tallulah Andrews, Gary D. Bader

{"title":"Interpretable single-cell factor decomposition using sciRED","authors":"Delaram Pouyabahar, Tallulah Andrews, Gary D. Bader","doi":"10.1038/s41467-025-57157-2","DOIUrl":"https://doi.org/10.1038/s41467-025-57157-2","url":null,"abstract":"Single-cell RNA sequencing maps gene expression heterogeneity within a tissue. However, identifying biological signals in this data is challenging due to confounding technical factors, sparsity, and high dimensionality. Data factorization methods address this by separating and identifying signals in the data, such as gene expression programs, but the resulting factors must be manually interpreted. We developed Single-Cell Interpretable REsidual Decomposition (sciRED) to improve the interpretation of scRNA-seq factor analysis. sciRED removes known confounding effects, uses rotations to improve factor interpretability, maps factors to known covariates, identifies unexplained factors that may capture hidden biological phenomena, and determines the genes and biological processes represented by the resulting factors. We apply sciRED to multiple scRNA-seq datasets and identify sex-specific variation in a kidney map, discern strong and weak immune stimulation signals in a PBMC dataset, reduce ambient RNA contamination in a rat liver atlas to help identify strain variation and reveal rare cell type signatures and anatomical zonation gene programs in a healthy human liver map. These demonstrate that sciRED is useful in characterizing diverse biological signals within scRNA-seq data.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"26 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anomalous δ15N values in the Neoarchean associated with an abundant supply of hydrothermal ammonium

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-22 DOI: 10.1038/s41467-025-57091-3

Ashley N. Martin, Eva E. Stüeken, Michelle M. Gehringer, Monika Markowska, Hubert Vonhof, Stefan Weyer, Axel Hofmann

引用次数: 0

Event-driven figure-ground organisation model for the humanoid robot iCub

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-22 DOI: 10.1038/s41467-025-56904-9

Giulia D’Angelo, Simone Voto, Massimiliano Iacono, Arren Glover, Ernst Niebur, Chiara Bartolozzi

{"title":"Event-driven figure-ground organisation model for the humanoid robot iCub","authors":"Giulia D’Angelo, Simone Voto, Massimiliano Iacono, Arren Glover, Ernst Niebur, Chiara Bartolozzi","doi":"10.1038/s41467-025-56904-9","DOIUrl":"https://doi.org/10.1038/s41467-025-56904-9","url":null,"abstract":"Figure-ground organisation is a perceptual grouping mechanism for detecting objects and boundaries, essential for an agent interacting with the environment. Current figure-ground segmentation methods rely on classical computer vision or deep learning, requiring extensive computational resources, especially during training. Inspired by the primate visual system, we developed a bio-inspired perception system for the neuromorphic robot iCub. The model uses a hierarchical, biologically plausible architecture and event-driven vision to distinguish foreground objects from the background. Unlike classical approaches, event-driven cameras reduce data redundancy and computation. The system has been qualitatively and quantitatively assessed in simulations and with event-driven cameras on iCub in various scenarios. It successfully segments items in diverse real-world settings, showing comparable results to its frame-based version on simple stimuli and the Berkeley Segmentation dataset. This model enhances hybrid systems, complementing conventional deep learning models by processing only relevant data in Regions of Interest (ROI), enabling low-latency autonomous robotic applications.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"23 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetic cation effect in alkaline hydrogen electrocatalysis and double layer proton transfer

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-21 DOI: 10.1038/s41467-025-56966-9

Peng Li, Ya-Ling Jiang, Yana Men, Yu-Zhou Jiao, Shengli Chen

{"title":"Kinetic cation effect in alkaline hydrogen electrocatalysis and double layer proton transfer","authors":"Peng Li, Ya-Ling Jiang, Yana Men, Yu-Zhou Jiao, Shengli Chen","doi":"10.1038/s41467-025-56966-9","DOIUrl":"https://doi.org/10.1038/s41467-025-56966-9","url":null,"abstract":"Unveiling the so far ambiguous mechanism of the significant dependence on the identity of alkali metal cation would prompt opportunities to solve the more than two orders of magnitude slowdown of hydrogen electrocatalytic kinetics in base relative to acid, which has hampered the effort to reduce the precious metal usage in fuel cells by using the hydroxide exchange membrane. Herein, we present atomic-scale evidences from ab-initio molecular dynamics simulation and in-situ surface-enhanced infrared absorption spectroscopy which show that it is the apparent discrepancies in the electric double-layer structures induced by differently sized cations that lead to largely different interfacial proton transfer barriers and therefore hydrogen electrocatalytic kinetics in base. Concretely, severe accumulation of larger cation in electric double-layer causes more discontinuous interfacial water distribution and H-bond network, thus rendering the proton transfer from bulk to interface more obstructed. Such notion is strikingly different from the previously envisioned impact of cation-intermediate interactions on the energetics of surface steps, providing a unique interfacial perspective for understanding the ubiquitous cation specificity in electrocatalysis.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"47 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Fully addressable designer superstructures assembled from one single modular DNA origami

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-02-21 DOI: 10.1038/s41467-025-57186-x

Johann M. Weck, Amelie Heuer-Jungemann

引用次数: 0