Nature Communications最新文献_第3页

Microscopic theory of polariton group velocity renormalization 极化子群速度重整化的微观理论

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-07-29 DOI: 10.1038/s41467-025-62276-x

Wenxiang Ying, Benjamin X. K. Chng, Milan Delor, Pengfei Huo

引用次数: 0

Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development 单核多组学分析确定了小鼠心脏发育模型中的异常心肌细胞

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-07-29 DOI: 10.1038/s41467-025-62208-9

Riley Leonard, Yi Zhao, Steven Eliason, Kathy Zimmerman, Ariana Batz, Cathy J. Hatcher, Robert M. Weiss, Mason Sweat, Xiao Li, Brad A. Amendt

{"title":"Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development","authors":"Riley Leonard, Yi Zhao, Steven Eliason, Kathy Zimmerman, Ariana Batz, Cathy J. Hatcher, Robert M. Weiss, Mason Sweat, Xiao Li, Brad A. Amendt","doi":"10.1038/s41467-025-62208-9","DOIUrl":"https://doi.org/10.1038/s41467-025-62208-9","url":null,"abstract":"Transcription factors such as Tbx5, Gata4, Mef2c and Pitx2 are required during cardiac development, and in adult cardiac homeostasis. We demonstrate that the gene dosage and modulation of these factors are mediated in vivo by the miR-200 family. Inhibition of a single miR-200 family member within the cluster results in defects of the left ventricle and cardiomyocyte maturation during development. Inhibition of the entire miR-200 family results in a ventricular septal defect and embryonic lethality by embryonic day (E)16.5. Inhibition of each miR-200 family has distinct heart phenotypes in cell specific differentiation and maturation. snRNA-sequencing reveals an immature cardiomyocyte cell state, suggesting reduced differentiation of these cells. The miR-200 family members are critical regulators of early cardiac development through maintaining cardiomyocyte differentiation and maturation. In this report, we identify several transcription factors regulated by miR-200 during heart development, a role for miR-200 in specific heart defects, and an abnormal cardiomyocyte population.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"27 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and evaluation of a tripartite chemogenetic fluorescent reporter for visualizing ternary protein complexes 用于可视化三元蛋白复合物的三方化学发生荧光报告基因的设计与评价

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-07-29 DOI: 10.1038/s41467-025-62241-8

Sara Bottone, Fanny Broch, Antoine Gedeon, Aurélien Brion, Lina El Hajji, Hela Benaissa, Arnaud Gautier

引用次数: 0

An on-chip phased array for non-classical light 用于非经典光的片上相控阵

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-07-29 DOI: 10.1038/s41467-025-61886-9

Volkan Gurses, Samantha I. Davis, Raju Valivarthi, Neil Sinclair, Maria Spiropulu, Ali Hajimiri

{"title":"An on-chip phased array for non-classical light","authors":"Volkan Gurses, Samantha I. Davis, Raju Valivarthi, Neil Sinclair, Maria Spiropulu, Ali Hajimiri","doi":"10.1038/s41467-025-61886-9","DOIUrl":"https://doi.org/10.1038/s41467-025-61886-9","url":null,"abstract":"Quantum science and technology can offer fundamental enhancements in sensing, communications and computing. The expansion from wired to wireless links is an exciting prospect for quantum technologies. For classical technologies, the advent of phased arrays enabled directional and adaptive wireless links by manipulating electromagnetic waves over free space. Here we demonstrate a phased array system on a chip that can receive, image and manipulate non-classical light over free space. We use an integrated photonic-electronic system with more than 1000 functional components on-chip to detect squeezed light. By integrating an array of 32 sub-wavelength engineered metamaterial antennas, we demonstrate a direct free-space-to-chip interface for reconfigurable quantum links. On the same chip, we implement a large-scale array of quantum-limited coherent receivers that can resolve non-classical signals simultaneously across 32 channels. With coherent readout and manipulation of these signals, we demonstrate 32-pixel imaging and spatially configurable reception of squeezed light over free space. Our work advances wireless quantum technologies that could enable practical applications in quantum communications and sensing.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"28 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images 从视网膜图像中筛选慢性肾脏疾病和常见病理类型的无创模型

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-07-29 DOI: 10.1038/s41467-025-62273-0

Qianni Wu, Jianbo Li, Lanqin Zhao, Dong Liu, Jingyi Wen, Yunuo Wang, Yiqin Wang, Naya Huang, Lanping Jiang, Qinghua Liu, Hanming Lin, Pengxia Wan, Shicong Yang, Wenfang Chen, Hongjian Ye, Mohammed Haji Rashid Hassan, Ahmed Hassan Nur, Zefang Dai, Jie Guo, Shanshan Zhou, Jianwen Yu, Weixing Zhang, Wenben Chen, Ruiyang Li, Wai Cheng Iao, Juan-juan Feng, Yan Wang, Hua Hong, Peihong Yin, Qing Ye, Chao Xie, Min Zhu, Xiaoyi Liu, Yaozhong Kong, Jie Wang, Ruiying Ma, Yu Xiao, Guoguang Chen, Rongguo Fu, Yuhe Ke, Jasmine Ong Chiat Ling, Charumathi Sabanayagam, Daniel Shu Wei Ting, Kar Keung Cheng, Duoru Lin, Wei Chen, Haotian Lin

{"title":"A noninvasive model for chronic kidney disease screening and common pathological type identification from retinal images","authors":"Qianni Wu, Jianbo Li, Lanqin Zhao, Dong Liu, Jingyi Wen, Yunuo Wang, Yiqin Wang, Naya Huang, Lanping Jiang, Qinghua Liu, Hanming Lin, Pengxia Wan, Shicong Yang, Wenfang Chen, Hongjian Ye, Mohammed Haji Rashid Hassan, Ahmed Hassan Nur, Zefang Dai, Jie Guo, Shanshan Zhou, Jianwen Yu, Weixing Zhang, Wenben Chen, Ruiyang Li, Wai Cheng Iao, Juan-juan Feng, Yan Wang, Hua Hong, Peihong Yin, Qing Ye, Chao Xie, Min Zhu, Xiaoyi Liu, Yaozhong Kong, Jie Wang, Ruiying Ma, Yu Xiao, Guoguang Chen, Rongguo Fu, Yuhe Ke, Jasmine Ong Chiat Ling, Charumathi Sabanayagam, Daniel Shu Wei Ting, Kar Keung Cheng, Duoru Lin, Wei Chen, Haotian Lin","doi":"10.1038/s41467-025-62273-0","DOIUrl":"https://doi.org/10.1038/s41467-025-62273-0","url":null,"abstract":"Chronic kidney disease (CKD) is a global health challenge, but invasive renal biopsies, the gold standard for diagnosis and prognosis, are often clinically constrained. To address this, we developed the kidney intelligent diagnosis system (KIDS), a noninvasive model for renal biopsy prediction using 13,144 retinal images from 6773 participants. The KIDS achieves an area under the receiver operating characteristic curve (AUC) of 0.839–0.993 for CKD screening and accurately identifies the five most common pathological types (AUC: 0.790–0.932) in a multicenter and multi-ethnic validation, outperforming nephrologists by 26.98% in accuracy. Additionally, the KIDS further predicts disease progression based on pathological classification. Given its flexible strategy, the KIDS can be adapted to local conditions to provide a tailored tool for patients. This noninvasive model has the potential to improve CKD clinical management, particularly for those who are ineligible for biopsies.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"20 1","pages":"6962"},"PeriodicalIF":16.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The structure of the Tad pilus alignment complex reveals a periplasmic conduit for pilus extension Tad菌毛排列复合体的结构揭示了菌毛延伸的质周导管

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-07-29 DOI: 10.1038/s41467-025-62457-8

Sasha L. Evans, Iryna Peretiazhko, Sahil Y. Karnani, Lindsey S. Marmont, James H. R. Wheeler, Boo Shan Tseng, William M. Durham, John C. Whitney, Julien R. C. Bergeron

{"title":"The structure of the Tad pilus alignment complex reveals a periplasmic conduit for pilus extension","authors":"Sasha L. Evans, Iryna Peretiazhko, Sahil Y. Karnani, Lindsey S. Marmont, James H. R. Wheeler, Boo Shan Tseng, William M. Durham, John C. Whitney, Julien R. C. Bergeron","doi":"10.1038/s41467-025-62457-8","DOIUrl":"https://doi.org/10.1038/s41467-025-62457-8","url":null,"abstract":"The Tad (Tight adherence) pilus is a bacterial appendage implicated in virulence, cell-cell aggregation, and biofilm formation. Despite its homology to the well-characterised Type IV pilus, the structure and assembly mechanism of the Tad pilus are poorly understood. Here, we investigate the role of the Tad pilus protein RcpC from Pseudomonas aeruginosa. Our analyses reveal that RcpC forms a dodecameric periplasmic complex, anchored to the inner membrane by a transmembrane helix, and interacting with the outer membrane secretin RcpA. We use single-particle Cryo-EM to elucidate the structure of the RcpC dodecamer, and cell-based assays to demonstrate that the RcpC-RcpA complex is essential for Tad-mediated cell-cell aggregation. Collectively, these data demonstrate that RcpC forms the Tad pilus alignment complex, which provides a conduit across the periplasm for the Tad pilus filament to access the extracellular milieu. Our experimental data and structure-based model allow us to propose a mechanism for Tad plus assembly.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"111 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vinyl cyclopropanes as a unifying platform for enantioselective remote difunctionalization of alkenes 乙烯基环丙烷作为烯烃对映选择性远端双官能化的统一平台

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-07-29 DOI: 10.1038/s41467-025-61363-3

Xiaoyong Du, Marc E. Lennon, Georgia Kriticou, Cristina Nevado

{"title":"Vinyl cyclopropanes as a unifying platform for enantioselective remote difunctionalization of alkenes","authors":"Xiaoyong Du, Marc E. Lennon, Georgia Kriticou, Cristina Nevado","doi":"10.1038/s41467-025-61363-3","DOIUrl":"https://doi.org/10.1038/s41467-025-61363-3","url":null,"abstract":"Asymmetric remote difunctionalization of alkenes is a longstanding challenge in synthetic chemistry, offering the potential to install two functional groups simultaneously across distal carbon atoms in a stereocontrolled manner. While ingenious strategies have been devised to achieve this transformation, a general catalytic system for remote, enantioselective hetero-carbofunctionalization and dicarbofunctionalization of alkenes has remained elusive. Here, we present a nickel/photoredox dual-catalyzed asymmetric remote 1,5-carbosulfonylation and 1,5-dicarbofunctionalization of vinyl cyclopropanes. This cascade reaction integrates radical addition, C–C bond cleavage, and cross-coupling to functionalize two distal carbon atoms with high enantioselectivity. Our protocol demonstrates broad substrate scope, excellent functional group tolerance, and significant synthetic utility, as evidenced by late-stage functionalization and product derivatization. Our mechanistic investigations support the involvement of a Ni(0)/Ni(I)/Ni(III) catalytic cycle in our system. This work establishes a versatile platform for remote alkene difunctionalization, expanding the toolbox of enantioselective synthetic methods and unlocking new avenues for complex molecule construction.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"18 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterogeneous preferences and asymmetric insights for AI use among welfare claimants and non-claimants 福利申领人和非福利申领人对人工智能使用的异质偏好和不对称见解

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-07-29 DOI: 10.1038/s41467-025-62440-3

Mengchen Dong, Jean-François Bonnefon, Iyad Rahwan

引用次数: 0

Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers 自分泌干扰素中毒介导brca1 /2突变癌症中adar1依赖的合成致死性

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-07-29 DOI: 10.1038/s41467-025-62309-5

Roman M. Chabanon, Liudmila Shcherbakova, Magali Lacroix-Triki, Marine Aglave, Jean Zeghondy, Victor Kriaa, Antoine Gougé, Marlène Garrido, Elodie Edmond, Ludovic Bigot, Dragomir B. Krastev, Rachel Brough, Stephen J. Pettitt, Thibault Thomas-Bonafos, Robert Samstein, Christophe Massard, Marc Deloger, Andrew NJ Tutt, Fabrice Barlesi, Yohann Loriot, Suzette Delaloge, Marcel Tawk, Cindy Degerny, Yea-Lih Lin, Barbara Pistilli, Philippe Pasero, Christopher J. Lord, Sophie Postel-Vinay

{"title":"Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers","authors":"Roman M. Chabanon, Liudmila Shcherbakova, Magali Lacroix-Triki, Marine Aglave, Jean Zeghondy, Victor Kriaa, Antoine Gougé, Marlène Garrido, Elodie Edmond, Ludovic Bigot, Dragomir B. Krastev, Rachel Brough, Stephen J. Pettitt, Thibault Thomas-Bonafos, Robert Samstein, Christophe Massard, Marc Deloger, Andrew NJ Tutt, Fabrice Barlesi, Yohann Loriot, Suzette Delaloge, Marcel Tawk, Cindy Degerny, Yea-Lih Lin, Barbara Pistilli, Philippe Pasero, Christopher J. Lord, Sophie Postel-Vinay","doi":"10.1038/s41467-025-62309-5","DOIUrl":"https://doi.org/10.1038/s41467-025-62309-5","url":null,"abstract":"ADAR1 is an RNA editing enzyme which prevents autoimmunity by blocking interferon responses triggered by cytosolic RNA sensors, and is a potential target in immuno-oncology. However, predictive biomarkers for ADAR1 inhibition are lacking. Using multiple in vitro and in vivo systems, we show that BRCA1/2 and ADAR1 are synthetically lethal, and that ADAR1 activity is upregulated in BRCA1/2-mutant cancers. ADAR1 depletion in BRCA1-mutant cells causes an increase in R-loops and consequently, an upregulation of cytosolic nucleic acid sensing pattern recognition receptors (PRR), events which are associated with a tumor cell-autonomous type I interferon and integrated stress response. This ultimately causes autocrine interferon poisoning. Consistent with a key role of R-loops in this process, exogenous RNase H1 expression reverses the synthetic lethality. Pharmacological suppression of cell-autonomous interferon responses or transcriptional silencing of cytosolic nucleic acid sensing PRR are also sufficient to abrogate ADAR1 dependency in BRCA1-mutant cells, in line with autocrine interferon poisoning playing a central part in this synthetic lethality. Our findings provide a preclinical rationale for assessing ADAR1-targeting agents in BRCA1/2-mutant cancers, and introduces a conceptually novel approach to synthetic lethal treatments, which exploits tumor cell-intrinsic cytosolic immunity as a targetable vulnerability of cancer cells.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":"6972"},"PeriodicalIF":16.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-dependent catalytic activity in aging condensates 老化凝析油的时效催化活性

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-07-29 DOI: 10.1038/s41467-025-62074-5

Wei Kang, Zhiyue Wu, Xinzhi Huang, Hongbin Qi, Jiaxuan Wu, Jiahui Wang, Jing Li, Sijin Wu, Byung-Ho Kang, Bo Li, Juncai Ma, Chuang Xue

引用次数: 0