Nature Communications最新文献_第3页

Local polar order controls mechanical stress and triggers layer formation in Myxococcus xanthus colonies

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-22 DOI: 10.1038/s41467-024-55806-6

Endao Han, Chenyi Fei, Ricard Alert, Katherine Copenhagen, Matthias D. Koch, Ned S. Wingreen, Joshua W. Shaevitz

{"title":"Local polar order controls mechanical stress and triggers layer formation in Myxococcus xanthus colonies","authors":"Endao Han, Chenyi Fei, Ricard Alert, Katherine Copenhagen, Matthias D. Koch, Ned S. Wingreen, Joshua W. Shaevitz","doi":"10.1038/s41467-024-55806-6","DOIUrl":"https://doi.org/10.1038/s41467-024-55806-6","url":null,"abstract":"Colonies of the social bacterium Myxococcus xanthus go through a morphological transition from a thin colony of cells to three-dimensional droplet-like fruiting bodies as a strategy to survive starvation. The biological pathways that control the decision to form a fruiting body have been studied extensively. However, the mechanical events that trigger the creation of multiple cell layers and give rise to droplet formation remain poorly understood. By measuring cell orientation, velocity, polarity, and force with cell-scale resolution, we reveal a stochastic local polar order in addition to the more obvious nematic order. Average cell velocity and active force at topological defects agree with predictions from active nematic theory, but their fluctuations are substantially larger than the mean due to polar active forces generated by the self-propelled rod-shaped cells. We find that M. xanthus cells adjust their reversal frequency to tune the magnitude of this local polar order, which in turn controls the mechanical stresses and triggers layer formation in the colonies.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"27 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deoxygenative photochemical alkylation of secondary amides enables a streamlined synthesis of substituted amines

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-22 DOI: 10.1038/s41467-025-56234-w

Antonio Pulcinella, Stefano Bonciolini, Robin Stuhr, Damiano Diprima, Minh Thao Tran, Magnus Johansson, Axel Jacobi von Wangelin, Timothy Noël

引用次数: 0

A lightweight prosthetic hand with 19-DOF dexterity and human-level functions

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-22 DOI: 10.1038/s41467-025-56352-5

Hao Yang, Zhe Tao, Jian Yang, Wenpeng Ma, Haoyu Zhang, Min Xu, Ming Wu, Shuaishuai Sun, Hu Jin, Weihua Li, Liu Wang, Shiwu Zhang

{"title":"A lightweight prosthetic hand with 19-DOF dexterity and human-level functions","authors":"Hao Yang, Zhe Tao, Jian Yang, Wenpeng Ma, Haoyu Zhang, Min Xu, Ming Wu, Shuaishuai Sun, Hu Jin, Weihua Li, Liu Wang, Shiwu Zhang","doi":"10.1038/s41467-025-56352-5","DOIUrl":"https://doi.org/10.1038/s41467-025-56352-5","url":null,"abstract":"A human hand has 23-degree-of-freedom (DOF) dexterity for managing activities of daily living (ADLs). Current prosthetic hands, primarily driven by motors or pneumatic actuators, fall short in replicating human-level functions, primarily due to limited DOF. Here, we develop a lightweight prosthetic hand that possesses biomimetic 19-DOF dexterity by integrating 38 shape-memory alloy (SMA) actuators to precisely control five fingers and the wrist. The prosthetic hand features real-time sensing of joint angles in each finger, feeding data into a control module for selectively heating or cooling SMA actuators in a closed-loop manner, mimicking the functioning of human muscles. Enabled by the high-power density of SMAs, the hand part (from the wrist to the fingertip) only weighs 0.22 kg, much lower than existing products. We also integrate an onboard power management module that provides electricity for operating the entire system. In addition to 33 standard grasping modes, this prosthetic hand supports 6 advanced grasping modes designed for enhanced dexterity evaluation, expanding the range of achievable ADLs for amputees while facilitating standard prosthesis function tests and validation in real-world scenarios. This innovation offers a significant advancement in prosthetic hand functions, promising improved quality of life for users.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"38 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seismic versus aseismic slip for the 2023 Kahramanmaraş earthquake doublet

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-22 DOI: 10.1038/s41467-025-56350-7

Rumeng Guo, Xiongwei Tang, Yijun Zhang, Wenting Zhang, Ming Qin, Jianqiao Xu, Jiangcun Zhou, Xuhao Zou, Heping Sun

引用次数: 0

PRMT1-methylated MSX1 phase separates to control palate development

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-22 DOI: 10.1038/s41467-025-56327-6

Li Meng, Yucheng Jiang, Jiawen You, Yatao Chen, Shuyu Guo, Liming Chen, Junqing Ma

{"title":"PRMT1-methylated MSX1 phase separates to control palate development","authors":"Li Meng, Yucheng Jiang, Jiawen You, Yatao Chen, Shuyu Guo, Liming Chen, Junqing Ma","doi":"10.1038/s41467-025-56327-6","DOIUrl":"https://doi.org/10.1038/s41467-025-56327-6","url":null,"abstract":"Little is known about the regulation and function of phase separation in craniofacial developmental disorders. MSX1 mutations are associated with human cleft palate, the most common craniofacial birth defect. Here, we show that MSX1 phase separation is a vertebrate-conserved mechanism underlying embryonic palatal fusion. Notably, MSX1 phase separation is triggered by its intrinsically disordered protein region (IDR) and regulated by PRMT1-catalyzed methylation, specifically asymmetric dimethylation of arginine in the MSX1 IDR including R150 and R157. Hypomethylated MSX1 due to methylation site mutations and PRMT1 deficiency consistently leads to abnormal MSX1 phase separation to form less dynamic gel-like condensates, resulting in proliferation defects of embryonic palatal mesenchymal cells and cleft palate. Besides, high frequency mutations in the MSX1 IDR, especially R157S, have been identified in humans with cleft palate. Overall, we reveal the function and regulatory pathway of MSX1 phase separation as a conserved mechanism underlying cleft palate, providing a proof-of-concept example of a phenotype-associated phase separation mechanism associated with craniofacial developmental disorders.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"6 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-22 DOI: 10.1038/s41467-025-56084-6

Xiaorong Wu, Alvin Surya Tjahyo, Vera Sergeyevna Brok Volchanskaya, Long Hui Wong, Xianning Lai, Yi Ning Yong, Farhana Osman, Shia Lyn Tay, Priya Govindharajulu, Shalini Ponnalagu, Rachel Tso, Hwee Sze Teo, Kaijie Khoo, Huan Fan, Chew Chan Goh, Clara Poh Lian Yap, Melvin Khee-Shing Leow, Christiani Jeyakumar Henry, Sumanto Haldar, Kevin Junliang Lim

{"title":"A legume-enriched diet improves metabolic health in prediabetes mediated through gut microbiome: a randomized controlled trial","authors":"Xiaorong Wu, Alvin Surya Tjahyo, Vera Sergeyevna Brok Volchanskaya, Long Hui Wong, Xianning Lai, Yi Ning Yong, Farhana Osman, Shia Lyn Tay, Priya Govindharajulu, Shalini Ponnalagu, Rachel Tso, Hwee Sze Teo, Kaijie Khoo, Huan Fan, Chew Chan Goh, Clara Poh Lian Yap, Melvin Khee-Shing Leow, Christiani Jeyakumar Henry, Sumanto Haldar, Kevin Junliang Lim","doi":"10.1038/s41467-025-56084-6","DOIUrl":"https://doi.org/10.1038/s41467-025-56084-6","url":null,"abstract":"Healthy dietary patterns rich in legumes can improve metabolic health, although their additional benefits in conjunction with calorie restriction have not been well-established. We investigated effects of a calorie-restricted, legume-enriched, multicomponent intervention diet compared with a calorie-restricted control diet in 127 Chinese prediabetes participants, living in Singapore. The study was a 16-week, single-blind, parallel-design, randomized controlled trial (n = 63 intervention group (IG), n = 64 control group (CG); mean ± SD age 62.2 ± 6.3 years, BMI 23.8 ± 2.6 kg/m2). Primary outcomes were markers of glycemia and all measurements were taken at 2 or 4-weekly intervals. At the end of 16 weeks, both groups had significantly lower BMI (q(Time) = 1.92 ×10-42, β = -0.02) compared with baseline, with minimal difference between groups. The IG had significantly greater reductions in LDL cholesterol (q(Treatment×Time) = 0.01, β = -0.16), total cholesterol (q(Treatment×Time) = 0.02, β = -0.3) and HbA1c (q(Treatment×Time) = 0.04, β = -0.004) compared with CG, alongside increases in fiber degrading species in IG, mediated through metabolites such as bile acids and amino acids. A legume-enriched, multicomponent intervention diet can improve metabolic health in a prediabetes population, in addition to benefits obtained from calorie restriction alone, partially mediated through changes in gut microbial composition and function. Trial registration: Clinical Trials NCT04745702.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"6 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probing and manipulating the Mexican hat-shaped valence band of In2Se3

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-22 DOI: 10.1038/s41467-025-56139-8

James Felton, Jordan Harknett, Joe Page, Zhuo Yang, Nada Alghofaili, James N. O’Shea, Laurence Eaves, Yoshimitsu Kohama, Mark T. Greenaway, Amalia Patanè

{"title":"Probing and manipulating the Mexican hat-shaped valence band of In2Se3","authors":"James Felton, Jordan Harknett, Joe Page, Zhuo Yang, Nada Alghofaili, James N. O’Shea, Laurence Eaves, Yoshimitsu Kohama, Mark T. Greenaway, Amalia Patanè","doi":"10.1038/s41467-025-56139-8","DOIUrl":"https://doi.org/10.1038/s41467-025-56139-8","url":null,"abstract":"Ferroelectrics based on van der Waals semiconductors represent an emergent class of materials for disruptive technologies ranging from neuromorphic computing to low-power electronics. However, many theoretical predictions of their electronic properties have yet to be confirmed experimentally and exploited. Here, we use nanoscale angle-resolved photoemission electron spectroscopy and optical transmission in high magnetic fields to reveal the electronic band structure of the van der Waals ferroelectric indium selenide (α-In2Se3). This indirect bandgap semiconductor features a weakly dispersed valence band, which is shaped like an inverted Mexican hat. Its form changes following an irreversible structural phase transition of α-In2Se3 into β-In2Se3 via a thermal annealing in ultra-high vacuum. Density functional theory supports the experiments and reveals the critical contribution of spin orbit coupling to the form of the valence band. The measured band structure and its in situ manipulation offer opportunities for precise engineering of ferroelectrics and their functional properties beyond traditional semiconducting systems.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"148 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA folding kinetics control riboswitch sensitivity in vivo

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-22 DOI: 10.1038/s41467-024-55601-3

David Z. Bushhouse, Jiayu Fu, Julius B. Lucks

{"title":"RNA folding kinetics control riboswitch sensitivity in vivo","authors":"David Z. Bushhouse, Jiayu Fu, Julius B. Lucks","doi":"10.1038/s41467-024-55601-3","DOIUrl":"https://doi.org/10.1038/s41467-024-55601-3","url":null,"abstract":"Riboswitches are ligand-responsive gene-regulatory RNA elements that perform key roles in maintaining cellular homeostasis. Understanding how riboswitch sensitivity to ligand (EC50) is controlled is critical to explain how highly conserved aptamer domains are deployed in a variety of contexts with different sensitivity demands. Here we uncover roles by which RNA folding dynamics control riboswitch sensitivity in cells. By investigating the Clostridium beijerinckii pfl ZTP riboswitch, we identify multiple mechanistic routes of altering expression platform sequence and structure to slow RNA folding, all of which enhance riboswitch sensitivity. Applying these methods to riboswitches with diverse aptamer architectures and regulatory mechanisms demonstrates the generality of our findings, indicating that any riboswitch that operates in a kinetic regime can be sensitized by slowing expression platform folding. Our results add to the growing suite of knowledge and approaches that can be used to rationally program cotranscriptional RNA folding for biotechnology applications, and suggest general RNA folding principles for understanding dynamic RNA systems in other areas of biology.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"57 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamically induced spatial segregation in multispecies bacterial bioconvection

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-22 DOI: 10.1038/s41467-025-56244-8

Oscar Gallardo-Navarro, Rinat Arbel-Goren, Elias August, Gabriela Olmedo-Alvarez, Joel Stavans

{"title":"Dynamically induced spatial segregation in multispecies bacterial bioconvection","authors":"Oscar Gallardo-Navarro, Rinat Arbel-Goren, Elias August, Gabriela Olmedo-Alvarez, Joel Stavans","doi":"10.1038/s41467-025-56244-8","DOIUrl":"https://doi.org/10.1038/s41467-025-56244-8","url":null,"abstract":"Active matter, from motile bacteria to animals, can exhibit striking collective and coherent behavior. Despite significant advances in understanding the behavior of homogeneous systems, little is known about the self-organization and dynamics of heterogeneous active matter, such as complex and diverse bacterial communities. Under oxygen gradients, many bacterial species swim towards air-liquid interfaces in auto-organized, directional bioconvective flows, whose spatial scales exceed the cell size by orders of magnitude. Here we show that multispecies bacterial suspensions undergoing oxytactic-driven bioconvection exhibit dynamically driven spatial segregation, despite the enhanced mixing of bioconvective flows, and the fact that these species coexist in their natural habitat. Segregation is observed as patterns of spatially interlocked domains, with local dominance of one of the constituent species in the suspension. Our findings suggest that segregation mechanisms are driven by species-specific motile behaviors under conditions of hydrodynamic flow, rather than biochemical repulsion. Thus, species with different motile characteristics in the same ecological context can enhance their access to limiting resources. This work provides novel insights on the role of heterogeneity in active matter, as well as on the dynamics of complex microbial communities, their spatial organization and their collective behavior.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"22 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2025-01-22 DOI: 10.1038/s41467-025-56309-8

Andrew S. Bray, Christopher A. Broberg, Andrew W. Hudson, Weisheng Wu, Ravinder K. Nagpal, Maidul Islam, Juan D. Valencia-Bacca, Fawaz Shahid, Giovanna E. Hernandez, Noah A. Nutter, Kimberly A. Walker, Emma F. Bennett, Taylor M. Young, Andrew J. Barnes, David A. Ornelles, Virginia L. Miller, M. Ammar Zafar

{"title":"Klebsiella pneumoniae employs a type VI secretion system to overcome microbiota-mediated colonization resistance","authors":"Andrew S. Bray, Christopher A. Broberg, Andrew W. Hudson, Weisheng Wu, Ravinder K. Nagpal, Maidul Islam, Juan D. Valencia-Bacca, Fawaz Shahid, Giovanna E. Hernandez, Noah A. Nutter, Kimberly A. Walker, Emma F. Bennett, Taylor M. Young, Andrew J. Barnes, David A. Ornelles, Virginia L. Miller, M. Ammar Zafar","doi":"10.1038/s41467-025-56309-8","DOIUrl":"https://doi.org/10.1038/s41467-025-56309-8","url":null,"abstract":"Microbial species must compete for space and nutrients to persist in the gastrointestinal (GI) tract, and our understanding of the complex pathobiont-microbiota interactions is far from complete. Klebsiella pneumoniae, a problematic, often drug-resistant nosocomial pathogen, can colonize the GI tract asymptomatically, serving as an infection reservoir. To provide insight on how K. pneumoniae interacts with the resident gut microbiome, we conduct a transposon mutagenesis screen using a murine model of GI colonization with an intact microbiota. Among the genes identified were those encoding a type VI secretion system (T6SS), which mediates contact-dependent killing of gram-negative bacteria. From several approaches, we demonstrate that the T6SS is critical for K. pneumoniae gut colonization. Metagenomics and in vitro killing assays reveal that K. pneumoniae reduces Betaproteobacteria species in a T6SS-dependent manner, thus identifying specific species targeted by K. pneumoniae. We further show that T6SS gene expression is controlled by several transcriptional regulators and that expression only occurs in vitro under conditions that mimic the gut environment. By enabling K. pneumoniae to thrive in the gut, the T6SS indirectly contributes to the pathogenic potential of this organism. These observations advance our molecular understanding of how K. pneumoniae successfully colonizes the GI tract.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"18 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0