Nature Communications最新文献_第3页

Environment heterogeneity creates fast amplifiers of natural selection in graph-structured populations. 环境异质性在图形结构的种群中创造了自然选择的快速放大器。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72784-z

Cecilia Fruet, Arthur Alexandre, Alia Abbara, Claude Loverdo, Anne-Florence Bitbol

{"title":"Environment heterogeneity creates fast amplifiers of natural selection in graph-structured populations.","authors":"Cecilia Fruet, Arthur Alexandre, Alia Abbara, Claude Loverdo, Anne-Florence Bitbol","doi":"10.1038/s41467-026-72784-z","DOIUrl":"https://doi.org/10.1038/s41467-026-72784-z","url":null,"abstract":"Complex spatial structure, with partially isolated subpopulations, and environment heterogeneity, such as gradients in nutrients, oxygen, and drugs, both shape the evolution of natural populations. We investigate the impact of environment heterogeneity on mutant fixation in spatially structured populations with demes on the nodes of a graph. When migrations between demes are frequent, we find that environment heterogeneity can amplify natural selection and simultaneously accelerate mutant fixation and extinction, thereby fostering the quick fixation of beneficial mutants. We demonstrate this effect in the star graph, and more strongly in the line graph. We show that amplification requires mutants to have a stronger fitness advantage in demes with stronger migration outflow, and that this condition allows amplification in more general graphs. As a baseline, we consider circulation graphs, where migration inflow and outflow are equal in each deme. In this case, environment heterogeneity has no impact to first order, but increases the fixation probability of beneficial mutants to second order. Finally, when migrations between demes are rare, we show that environment heterogeneity can also foster amplification of selection, by allowing demes with sufficient mutant advantage to become refugia for mutants.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endosome maturation is orchestrated by inside-out proton signaling through a Na⁺/H⁺ exchanger and pH-dependent Rab GTPase cycling. 内核体成熟是通过Na+/H+交换器和ph依赖性Rab GTPase循环由内向外的质子信号调控的。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72568-5

YouJin Lee, Qing Ouyang, Li Ma, Morgan Fleishman, Hasib Aamir Riaz, Michael Schmidt, Jeffrey L Dupree, Anupam Mondal, Priyesh Mohanty, Jeetain Mittal, Oliver Beckstein, David G Lambright, Eric M Morrow

{"title":"Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling.","authors":"YouJin Lee, Qing Ouyang, Li Ma, Morgan Fleishman, Hasib Aamir Riaz, Michael Schmidt, Jeffrey L Dupree, Anupam Mondal, Priyesh Mohanty, Jeetain Mittal, Oliver Beckstein, David G Lambright, Eric M Morrow","doi":"10.1038/s41467-026-72568-5","DOIUrl":"https://doi.org/10.1038/s41467-026-72568-5","url":null,"abstract":"Endosome maturation requires lumen acidification. Is progressive lumen acidification sensed by cytosolic-side molecules driving maturation? We show here that proton efflux through the endosomal Na⁺/H⁺ Exchanger (NHE6) activates the late endosome master regulator Rab7. Importantly, NHE6 is mutated in the childhood neurologic disorder Christianson Syndrome. We demonstrate that NHE6 interacts with the Rab7 GTPase-activating protein (GAP) TBC1D5 in a complex with Rab7 on the late endosome. This interaction and proton efflux are both required for Rab7 activation. TBC1D5 is potently inactivated with decreasing pH. A conserved histidine in the TBC1D5 GAP domain mediates pH-dependence. Furthermore, we show that neurons from mice engineered with a selective defect in NHE6 proton efflux exhibit blocked endosome maturation and disrupted Rab7 GTP-GDP cycling. In addition, knock-down of TBC1D5, thereby reducing Rab7 GAP activity, in NHE6 mutant neurons rescues Rab7 GTP-GDP cycling and endosome maturation. Finally, we present a biophysical model of proton signaling through acidic pH microdomains within the NHE6-TBC1D5-Rab7 protein complex upon endosome acidification. In conclusion, our studies provide evidence supporting a mechanism involving \"inside-out\" proton signaling, whereby lumen acidification drives endosome maturation through pH-dependent Rab GTPase cycling. Failure in this mechanism may have broad impact in neurodegenerative disease.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solvation structure of hydrated electrons overlooked in the degradation of PFAS by UV/sulfite. 紫外光/亚硫酸盐降解PFAS过程中忽略的水合电子的溶剂化结构。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72906-7

Xu Liu, Fang Li, Zhicheng Zhang, Tong Guan, Boxue Pang, Delin Qi, Wei Wang, Yang Wu, Shubo Deng

{"title":"Solvation structure of hydrated electrons overlooked in the degradation of PFAS by UV/sulfite.","authors":"Xu Liu, Fang Li, Zhicheng Zhang, Tong Guan, Boxue Pang, Delin Qi, Wei Wang, Yang Wu, Shubo Deng","doi":"10.1038/s41467-026-72906-7","DOIUrl":"https://doi.org/10.1038/s41467-026-72906-7","url":null,"abstract":"The UV/sulfite system is currently regarded as the most effective method for degrading and defluorinating per- and poly-fluoroalkyl substances (PFAS), operating via hydrated electrons (eaq-). Previous studies largely concentrate on PFAS molecular structure, overlooking the critical influence of eaq- microstructure. By integrating ab initio molecular dynamics simulations with experiments, we reveal strong correlations between cavity radius and PFAS removal efficiency (R2 = 0.99) and defluorination reaction (R2 = 0.89). Expanding the cavity radius enhances spin density at its centre (R2 = 0.83), increasing the availability of solvated electrons for interaction with PFAS active sites and facilitating diffusion-controlled electron transfer that drives defluorination. Under alkaline conditions, an increase in cavity radius from 1.52 to 1.82 Å enhances spin-density delocalisation within the eaq- cavity, improving degradation efficiency. These findings are supported by experimental results revealing >97% degradation of hexafluoropropylene oxide dimer acid (or its ammonium salt 'GenX') at pH 12. Concentrated eaq- enables cooperative multi-site attack on PFAS molecules, accounting for the enhanced defluorination. Overall, this study reveals an atomic-scale correlation between eaq- microstructure and defluorination dynamics. Beyond conventional approaches of modifying PFAS structures, we propose that regulating the solvation structure of eaq- offers a strategy for efficient degradation.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification of disease-associated RNA tandem repeats by nanopore sensing. 通过纳米孔传感定量疾病相关RNA串联重复序列。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72819-5

Gerardo Patiño-Guillén, Jovan Pešović, Marko Panić, Max Earle, Anastasija Ninković, Sergiu Petrușca, Dušanka Savić-Pavićević, Ulrich F Keyser, Filip Bošković

{"title":"Quantification of disease-associated RNA tandem repeats by nanopore sensing.","authors":"Gerardo Patiño-Guillén, Jovan Pešović, Marko Panić, Max Earle, Anastasija Ninković, Sergiu Petrușca, Dušanka Savić-Pavićević, Ulrich F Keyser, Filip Bošković","doi":"10.1038/s41467-026-72819-5","DOIUrl":"https://doi.org/10.1038/s41467-026-72819-5","url":null,"abstract":"Short tandem repeat expansions underlie a class of neurological and neuromuscular diseases known as repeat expansion disorders, yet the precise characterisation of these repeats remains technically challenging. Conventional amplification-based methods fail to resolve repeat length accurately due to amplification bias and sequence homogeneity. Here, we present a single-molecule nanopore-based strategy that enables direct quantification of tandem repeats in native RNA. By assembling RNA:DNA nanostructures that encode specific repeat number, we achieve repeat size discrimination with a resolution of 18 nucleotides. Using tandem repeat-containing RNA, we successfully detect and discriminate disease-relevant repeat lengths associated with myotonic dystrophy types 1 (DM1) and 2 (DM2), and congenital central hypoventilation syndrome-1. Finally, we apply our method to total RNA extracted from a DM1 human cell line model, demonstrating its compatibility with complex biological samples. Our approach offers a platform for studying repeat expansion biology at the single-molecule level, with broad implications for diagnostics, clinical research and multiplexed repeat profiling.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Piezochromic hydrogels for physically unclonable optical anti-counterfeiting with machine-learning assisted automatic identification. 用于物理不可克隆光学防伪与机器学习辅助自动识别的压致变色水凝胶。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-73060-w

Jiayi Yang, Jiayu Wu, Guoliang Xiao, Zhenxing Jin, Cun You, Changcheng Bai, Runnan Ye, Pinwen Zhu, Guanjun Xiao, Shunxin Li, Xiaolong Wang, Bo Zou

{"title":"Piezochromic hydrogels for physically unclonable optical anti-counterfeiting with machine-learning assisted automatic identification.","authors":"Jiayi Yang, Jiayu Wu, Guoliang Xiao, Zhenxing Jin, Cun You, Changcheng Bai, Runnan Ye, Pinwen Zhu, Guanjun Xiao, Shunxin Li, Xiaolong Wang, Bo Zou","doi":"10.1038/s41467-026-73060-w","DOIUrl":"https://doi.org/10.1038/s41467-026-73060-w","url":null,"abstract":"Developing high-security anticounterfeiting with reliable authentication remains a significant challenge in preventing information leakage and economic losses from counterfeiting. Here, we successfully reported physically uncopiable optical system based on piezochromic polymer hydrogels (PPH). Pressure treatment induces a clustering-triggered emission transition from red to blue, driven by suppressed through-space interactions and reduced electron delocalization, with the blue-emissive state stably retained after pressure release. Stochastic spatial distribution of red- and blue-emissive particles generates physically unclonable patterns with high distinguishability. Statistical analysis reveals near-ideal randomness together with high uniqueness and reliability. A similarity-based machine learning framework enables rapid and robust authentication, overcoming the subjectivity and inefficiency of human-eye recognition. This work establishes piezochromic polymer hydrogels as a platform for physically unclonable optical systems for secure anti-counterfeiting.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maternal RSV vaccination generates high-affinity antibodies that efficiently transfer to infants, providing enhanced passive immunity. 母体RSV疫苗产生高亲和力抗体，有效地转移给婴儿，提供增强的被动免疫。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72659-3

Dongxiao Liu, Olivia Posadas, Ashish K Mishra, Mohamed M Mire, Mindy Pike, Janet A Englund, Alisa Kachikis, Surender Khurana

{"title":"Maternal RSV vaccination generates high-affinity antibodies that efficiently transfer to infants, providing enhanced passive immunity.","authors":"Dongxiao Liu, Olivia Posadas, Ashish K Mishra, Mohamed M Mire, Mindy Pike, Janet A Englund, Alisa Kachikis, Surender Khurana","doi":"10.1038/s41467-026-72659-3","DOIUrl":"https://doi.org/10.1038/s41467-026-72659-3","url":null,"abstract":"Respiratory syncytial virus (RSV) remains the leading cause of hospitalization in young children. A bivalent pre-fusion (preF) protein RSV vaccine was licensed for pregnant persons in 2023 (Abrysvo, Pfizer), but the impact of RSV maternal immunization on maternal-fetal immunity has not been well characterized. We analyze neutralizing antibody responses, binding antibodies, and antibody affinity maturation in 58 unvaccinated and 49 vaccinated pregnant individuals and their infants. Maternal RSV vaccination induces robust neutralizing antibodies against both RSV-A2 and RSV-B1 strains, with geometric mean titers 8-fold and 13.4-fold higher, respectively, in vaccinated versus unvaccinated participants. Vaccination significantly enhances binding antibodies to RSV-preF protein (5.2-fold higher) and antibody affinity maturation (3.7-fold higher). High-quality RSV-specific antibodies are efficiently transferred across the placenta. However, early preterm infants showed reduced antibody transfer efficiency compared with full-term infants. These findings demonstrate that maternal RSV vaccination generates high-quality, affinity-matured transferable antibodies that provide passive immunity to infants.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resolving liquid-to-glass transitions of water under soft nanoconfinement. 在软纳米约束下解决水的液体到玻璃的转变。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72955-y

Patrick Züblin, Eva Zunzunegui-Bru, Livia Salvati Manni, Alice Klapproth, Richard Mole, Nageshwar Rao Yepuri, Syrine Khaled, Guillaume Pierre Laurent, Thierry Azaïs, Serena Rosa Alfarano, Jean-Blaise Brubach, Salvatore Assenza, Francesco Sciortino, Raffaele Mezzenga

{"title":"Resolving liquid-to-glass transitions of water under soft nanoconfinement.","authors":"Patrick Züblin, Eva Zunzunegui-Bru, Livia Salvati Manni, Alice Klapproth, Richard Mole, Nageshwar Rao Yepuri, Syrine Khaled, Guillaume Pierre Laurent, Thierry Azaïs, Serena Rosa Alfarano, Jean-Blaise Brubach, Salvatore Assenza, Francesco Sciortino, Raffaele Mezzenga","doi":"10.1038/s41467-026-72955-y","DOIUrl":"https://doi.org/10.1038/s41467-026-72955-y","url":null,"abstract":"Water has challenged scientists with numerous anomalies and confounding problems since the very early times. The kinetic glass transition of bulk water is a pristine example, as its location remains mostly inaccessible to experimentalists in an area below about -41 °C, where bulk water spontaneously crystallises. Confining water within nanometre-sized domains is an intriguing approach inspired by the cellular environment in nature to completely prevent crystallisation. Here we probe the existence of liquid-to-glass transitions of water nanoconfined between non-freezing lipidic bilayers and find a peculiar and counterintuitive regime over an extended temperature range, for which a sub-nanometre layer of water remains glassy in between fluid (mobile) walls of lipidic molecules. We provide comprehensive evidence for a slowing down of water dynamics under soft nanoconfinement occurring in the -63 to -20 °C range across six orders of magnitude in time scales from 10-6 to 10-12 s, and a static glass transition ranging between -74 and -64 °C. These findings provide important insights into the elusive glass transition of water under nanoconfinement, with broader implications for all those areas where water is confined at the nanometre scale below its freezing point.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging hydrogen-bond-stabilized polymeric coacervate core micelles for high-efficiency drug encapsulation and delivery. 桥接氢键稳定聚合物凝聚核心胶束用于高效药物包封和递送。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72978-5

Jiafeng Wang, Jiajia Ying, Jianxiang Huang, Longchen Zhu, Hang Yang, JunJun Li, Zimeng Liu, Yongli Mu, Changhuo Xu, Kefeng Ding, Xin Zhang, Tianhua Zhou, Xiangrui Liu, Youqing Shen, Quan Zhou

{"title":"Bridging hydrogen-bond-stabilized polymeric coacervate core micelles for high-efficiency drug encapsulation and delivery.","authors":"Jiafeng Wang, Jiajia Ying, Jianxiang Huang, Longchen Zhu, Hang Yang, JunJun Li, Zimeng Liu, Yongli Mu, Changhuo Xu, Kefeng Ding, Xin Zhang, Tianhua Zhou, Xiangrui Liu, Youqing Shen, Quan Zhou","doi":"10.1038/s41467-026-72978-5","DOIUrl":"https://doi.org/10.1038/s41467-026-72978-5","url":null,"abstract":"Polymeric nanoparticles represent one of the most promising classes of non-lipid-based drug delivery vehicles. However, their clinical translation remains limited by poor drug loading capacity and suboptimal delivery efficiency. We here develop one type of polymeric nanoparticles, referred to as PCCMs (Polymeric Coacervate Core Micelles), which are assembled from a sulfoxide-containing block polymer. Hydrophobic drugs can be efficiently encapsulated into PCCMs via a fast, low-energy \"Mix-and-Go\" approach, reducing reliance on organic solvents and simplifying the drug-loading process. Moreover, PCCMs show high drug loading capacities and improved stability towards versatile hydrophobic drugs. Upon evaluating 40 different drugs, 45% of the tested compounds achieve drug loading contents exceeding 40%, 80% exceed 30%, and 100% surpass 20%. Both quantitative structure-property relationship (QSPR) calculations and experimental methods identify that hydration water within PCCMs' self-coacervated cores acts as the molecular barrier, substantially inhibiting long-range-ordered drug molecule packing and stabilizing drug aggregates at the nanoscale via bridging hydrogen bonds among the polymer-water-drug. Finally, we demonstrate that PCCMs exhibit significantly higher systemic delivery efficacy compared to commercial polymeric micelle formulations in female BALB/c mice. The high loading capacity, versatility, and efficacy of PCCMs pave the way for the clinical translation of polymeric nanoparticles.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumors hijack immune-privileging regulons via distinct cell types to confer T cell desertion and immunotherapy resistance across various cancers. 肿瘤通过不同的细胞类型劫持免疫特权调节，赋予T细胞遗弃和免疫治疗抵抗在各种癌症。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-72538-x

Bashir Lawal, Akshat Gupta, Renu Sharma, Huayan Ren, Rohit Bhargava, Yue Wang, Xiao-Song Wang

{"title":"Tumors hijack immune-privileging regulons via distinct cell types to confer T cell desertion and immunotherapy resistance across various cancers.","authors":"Bashir Lawal, Akshat Gupta, Renu Sharma, Huayan Ren, Rohit Bhargava, Yue Wang, Xiao-Song Wang","doi":"10.1038/s41467-026-72538-x","DOIUrl":"https://doi.org/10.1038/s41467-026-72538-x","url":null,"abstract":"Immune checkpoint blockade (ICB) has transformed oncology, yet most patients fail to respond, suffer from hyper-progressive disease, or face severe immune-related toxicities, underscoring the urgent need for biomarkers that identify non-responders. Here we show that tumors co-opt an immune-privileging regulon signature (IMPREG) mirroring transcriptional programs of immune-privileged organs - to enforce T-cell desertion and ICB resistance across solid tumor types. Single-cell and spatial transcriptomic analyses reveal that tumors activate IMPREG through three distinct cellular routes: malignant cells adopting immature neuronal states, cancer-associated fibroblasts assuming myofibroblast identities, or endothelial cells - each creating localized niches of immune suppression and antigen-presentation collapse. Across 4 discovery and 36 validation clinical datasets, IMPREG consistently predicts immunotherapy resistance in 14 distinct cancer types, functioning as an orthogonal marker independent of established biomarkers. Crucially, IMPREG-expressing tumors show enhanced sensitivity to EGFR inhibitors or anti-angiogenic therapies in specific tumor entities. These findings suggest IMPREG as a dual-utility predictive biomarker for personalized treatment stratification.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":" ","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-contact laser polishing and reconstruction towards high-efficiency all-perovskite tandem solar cells. 高效全钙钛矿串联太阳能电池的非接触式激光抛光与重构。

IF 15.7 1区综合性期刊

Nature Communications Pub Date : 2026-05-08 DOI: 10.1038/s41467-026-71017-7

Tianjun Ma, Dingfu Luo, Wenjiang Ye, Xinzhao Zhao, Jun Yan, Hao Wang, Ruiheng Gao, XuKe Yang, Mingyu Li, Yuheng Li, Sifan Liu, Salman Ali, Qilin Guo, Bingxin Ding, Shiwu Chen, Michael Wang, Chris Cheng, Ying Zhou, Chao Chen, Pingli Qin, Haisheng Song, Jiang Tang

{"title":"Non-contact laser polishing and reconstruction towards high-efficiency all-perovskite tandem solar cells.","authors":"Tianjun Ma, Dingfu Luo, Wenjiang Ye, Xinzhao Zhao, Jun Yan, Hao Wang, Ruiheng Gao, XuKe Yang, Mingyu Li, Yuheng Li, Sifan Liu, Salman Ali, Qilin Guo, Bingxin Ding, Shiwu Chen, Michael Wang, Chris Cheng, Ying Zhou, Chao Chen, Pingli Qin, Haisheng Song, Jiang Tang","doi":"10.1038/s41467-026-71017-7","DOIUrl":"https://doi.org/10.1038/s41467-026-71017-7","url":null,"abstract":"The performance of all-perovskite tandem solar cells is critically hindered by the defective and high-roughness surfaces of lead-tin narrow-bandgap subcells, which induce non-radiative recombination and impede carrier extraction. Herein, we report a robust and multifunctional strategy to convert the above narrow-bandgap perovskite surface into an efficient and smooth one by a picosecond ultraviolet pulsed laser polishing technology combined with surface reconstruction. The polished surface is decoded as [PbI₆]⁴⁻/[SnI₆]⁴⁻ octahedral frameworks with metastable A-site vacancies. By screening guanidinium bromide as an A-site passivator, the polished surface is reconstructed into a guanidinium-cesium-based perovskite phase, substantially enhancing carrier extraction and suppressing ion migration. The resulting single-junction lead-tin and tandem solar cells, fabricated via an antisolvent-free method, achieve efficiencies of 23.47% (certified) and 29.80%, respectively, alongside exceptional operational stability. This versatile interface engineering paradigm surmounts a pivotal barrier in the advancement of next-generation photovoltaic technologies.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"17 1","pages":""},"PeriodicalIF":15.7,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0