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Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation. Anle138b主要结合脂质Aβ₄0原纤维的中心腔并调节原纤维的形成。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-03 DOI: 10.1038/s41467-025-64443-6
Mookyoung Han,Benedikt Frieg,Dirk Matthes,Andrei Leonov,Sergey Ryazanov,Karin Giller,Evgeny Nimerovsky,Marianna Stampolaki,Kai Xue,Kerstin Overkamp,Christian Dienemann,Dietmar Riedel,Armin Giese,Stefan Becker,Bert L de Groot,Gunnar F Schröder,Loren B Andreas,Christian Griesinger
{"title":"Anle138b binds predominantly to the central cavity in lipidic Aβ₄₀ fibrils and modulates fibril formation.","authors":"Mookyoung Han,Benedikt Frieg,Dirk Matthes,Andrei Leonov,Sergey Ryazanov,Karin Giller,Evgeny Nimerovsky,Marianna Stampolaki,Kai Xue,Kerstin Overkamp,Christian Dienemann,Dietmar Riedel,Armin Giese,Stefan Becker,Bert L de Groot,Gunnar F Schröder,Loren B Andreas,Christian Griesinger","doi":"10.1038/s41467-025-64443-6","DOIUrl":"https://doi.org/10.1038/s41467-025-64443-6","url":null,"abstract":"Alzheimer's disease is a specific neurodegenerative disorder, distinct from normal aging, with a growing unmet medical need. It is characterized by the accumulation of amyloid plaques in the brain, primarily consisting of amyloid beta (Aβ) fibrils. Therapeutic antibodies can slow down the disease, but are associated with potential severe side effects, motivating the development of small molecules to halt disease progression. This study investigates the interaction between the clinical drug candidate small molecule anle138b and lipidic Aβ₄₀ fibrils of type 1 (L1). L1 fibrils were previously shown to closely resemble fibrils from Alzheimer's patients. Using high-resolution structural biology techniques, including cryo-electron microscopy (cryo-EM), nuclear magnetic resonance (NMR) spectroscopy enhanced by dynamic nuclear polarization (DNP), and molecular dynamics (MD) simulations, we find that anle138b selectively binds to a cavity within the fibril. This structural insight provides a deeper understanding of a potential drug-binding mechanism at the atomic level and may inform the development of therapies and diagnostic approaches. In addition, anle138b reduces fibril formation in the presence of lipids by approximately 75%. This may suggest a mechanistic connection to its previously reported activity in animal models of Alzheimer's disease.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"121 1","pages":"8850"},"PeriodicalIF":16.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Boosting and stabilizing oxygen evolution reaction through Ru single atoms anchored amorphous NiMoOx electrocatalyst. Ru单原子锚定非晶NiMoOx电催化剂促进和稳定析氧反应。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-03 DOI: 10.1038/s41467-025-63870-9
Jiayi Li,Yiming Zhu,Changyuan Li,Qian Zhang,Ju Rong,Shasha Guo,Nicolas Alonso-Vante,Long Yang,Min-Hsin Yeh,Wei-Hsiang Huang,Xiaohua Yu,Hongfei Cheng,Jiwei Ma
{"title":"Boosting and stabilizing oxygen evolution reaction through Ru single atoms anchored amorphous NiMoOx electrocatalyst.","authors":"Jiayi Li,Yiming Zhu,Changyuan Li,Qian Zhang,Ju Rong,Shasha Guo,Nicolas Alonso-Vante,Long Yang,Min-Hsin Yeh,Wei-Hsiang Huang,Xiaohua Yu,Hongfei Cheng,Jiwei Ma","doi":"10.1038/s41467-025-63870-9","DOIUrl":"https://doi.org/10.1038/s41467-025-63870-9","url":null,"abstract":"Efficient and durable electrocatalysts for the oxygen evolution reaction (OER) are essential for advancing water splitting technologies, which enable sustainable hydrogen production. The integration of amorphous oxide supports with metal single atoms offers a promising strategy to precisely tuning the electronic structure and improving the exposure of active sites. Here, we report an amorphous NiMoOx support anchored with Ru single atoms (denoted as a-RNMO), which achieves a low cell voltage of 1.78 V at 1 A cm-2 and noteworthy durability in an anion exchange membrane water electrolyzer. Time-resolved operando Quick X-ray absorption spectroscopy reveals rapid Mo leaching followed by structural reconstruction, culminating in the NiOOH formation. Theoretical calculations suggest a likely \"complementary amorphous-electronic\" mechanism. It shows that the amorphous structure exposes more active sites and favors the adsorption of intermediates, while Ru single atoms finely modulate the electronic structure. These valuable insights highlight the design of high-performance OER electrocatalysts based on metal single atoms anchored on amorphous oxides.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"121 1","pages":"8827"},"PeriodicalIF":16.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: Oxygen spillover on supported Pt-cluster for anti-CO-poisoning hydrogen oxidation. 出版商更正:氧气溢出支持pt簇抗co中毒氢氧化。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-03 DOI: 10.1038/s41467-025-64767-3
Di Shen,Fanfei Sun,Zhijian Liang,Bingbao Mei,Ying Xie,Yucheng Wang,Lei Wang,Honggang Fu
{"title":"Publisher Correction: Oxygen spillover on supported Pt-cluster for anti-CO-poisoning hydrogen oxidation.","authors":"Di Shen,Fanfei Sun,Zhijian Liang,Bingbao Mei,Ying Xie,Yucheng Wang,Lei Wang,Honggang Fu","doi":"10.1038/s41467-025-64767-3","DOIUrl":"https://doi.org/10.1038/s41467-025-64767-3","url":null,"abstract":"","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"78 1","pages":"8844"},"PeriodicalIF":16.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A stable monoclinic variant and resultant robust ferroelectricity in single-crystalline hafnia-based films. 在单晶铪基薄膜中稳定的单斜变异体和由此产生的强大铁电性。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-03 DOI: 10.1038/s41467-025-63907-z
Wan-Rong Geng,Yu-Jia Wang,Yin-Lian Zhu,Sirui Zhang,Huiqin Ma,Yun-Long Tang,Shi Tuo,Xiu-Liang Ma
{"title":"A stable monoclinic variant and resultant robust ferroelectricity in single-crystalline hafnia-based films.","authors":"Wan-Rong Geng,Yu-Jia Wang,Yin-Lian Zhu,Sirui Zhang,Huiqin Ma,Yun-Long Tang,Shi Tuo,Xiu-Liang Ma","doi":"10.1038/s41467-025-63907-z","DOIUrl":"https://doi.org/10.1038/s41467-025-63907-z","url":null,"abstract":"The ferroelectricity in nanoscale HfO2-based films enables their applications more promising than that of the perovskite oxides, taking into account the easy compatibility with the modern silicon-based semiconductor technology. However, the well-known polar orthorhombic phase is thermodynamically metastable, making the applications of HfO2-based ferroelectrics challenging in terms of uncontrollability and consequently instability of the physical performance in electronic devices. Here we report the robust ferroelectricity in stable monoclinic Hf0.5Zr0.5O2 single-crystalline films, which was known as non-polar before. The as-prepared films display high endurance performance of wake-up free and non-fatigue behavior up to 1012 cycles. Multimode imaging under aberration-corrected scanning transmission electron microscopy reveals that such an unexpected ferroelectric behavior is resultant from an antiphase boundaries-derived monoclinic polar variant (space group, Pc) intergrown with the nonpolar monoclinic phase (P21/c). The switching barrier for the stable polar variant is only 20~50% of that for the metastable orthorhombic phase according to the calculation by the nudged elastic band method. These findings provide a practical approach for designing robust ferroelectricity in hafnia-based materials and would be helpful for the development of lower energy-cost and long-life memory devices compatible with integrated circuit technology.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"12 1","pages":"8842"},"PeriodicalIF":16.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Floquet control of interactions and edge states in a programmable quantum simulator. 可编程量子模拟器中相互作用和边缘状态的Floquet控制。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-03 DOI: 10.1038/s41467-025-62897-2
Or Katz,Lei Feng,Diego Porras,Christopher Monroe
{"title":"Floquet control of interactions and edge states in a programmable quantum simulator.","authors":"Or Katz,Lei Feng,Diego Porras,Christopher Monroe","doi":"10.1038/s41467-025-62897-2","DOIUrl":"https://doi.org/10.1038/s41467-025-62897-2","url":null,"abstract":"Quantum simulators based on trapped ions enable the study of spin systems and models with rich dynamical phenomena. The Su-Schrieffer-Heeger (SSH) model for fermions in one dimension is a canonical example that can support a topological insulator phase when couplings between sites are dimerized, featuring long-lived edge states. Here, we experimentally implement a spin-based variant of the SSH model using one-dimensional trapped-ion chains with tunable interaction range, realized in crystals containing up to 22 interacting spins. Using an array of individually focused laser beams, we apply site-specific, time-dependent Floquet fields to induce controlled bond dimerization. Under conditions that preserve inversion symmetry, we observe edge-state dynamics consistent with SSH-like behavior. We study the propagation and localization of spin excitations, as well as the evolution of highly excited configurations across different interaction regimes. These results demonstrate how precision Floquet engineering enables the exploration of complex spin models and dynamics, laying the groundwork for future preparation and characterization of topological and exotic phases of matter.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"32 1","pages":"8815"},"PeriodicalIF":16.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interfacial chemistry-driven reaction dynamics and resultant microstructural evolution in lithium-based all-solid-state batteries. 锂基全固态电池界面化学驱动的反应动力学及其微观结构演变。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-03 DOI: 10.1038/s41467-025-63959-1
Chanhyun Park,Jingyu Choi,Seojoung Park,Hyeong-Jong Kim,Yunseo Kim,Gukhyun Lim,Juho Lee,Eunryeol Lee,Sugeun Jo,Jiwon Kim,Jinsoo Kim,Jun Lim,Taeseok Kim,Jihyun Hong,Donghyuk Kim,Sung-Kyun Jung
{"title":"Interfacial chemistry-driven reaction dynamics and resultant microstructural evolution in lithium-based all-solid-state batteries.","authors":"Chanhyun Park,Jingyu Choi,Seojoung Park,Hyeong-Jong Kim,Yunseo Kim,Gukhyun Lim,Juho Lee,Eunryeol Lee,Sugeun Jo,Jiwon Kim,Jinsoo Kim,Jun Lim,Taeseok Kim,Jihyun Hong,Donghyuk Kim,Sung-Kyun Jung","doi":"10.1038/s41467-025-63959-1","DOIUrl":"https://doi.org/10.1038/s41467-025-63959-1","url":null,"abstract":"Achieving a comprehensive understanding of battery systems necessitates multi-length scale analysis, from the atomic- to macro-scale, to grasp the complex interplay of phenomena influencing performance. However, studies to understand these phenomena in all-solid-state batteries (ASSBs) poses significant challenges due to the complex microstructural evolution involved, including the pore formation and contact loss resulting from cathode material breathing, chemical degradation at interfaces, and their interplay. Herein, we investigate the impact of chemical degradation on the reaction behavior and microstructural evolution of Ni-rich cathode particle (LiNi0.6Co0.2Mn0.2O2) within composite cathodes of sulfide-based ASSBs, using a well-defined model system incorporating Li-In alloy anodes and a non-decomposable coating layer that solely alters the interfacial chemical reactivity. By using lithium difluorophosphate (LiDFP) to suppress chemical degradation, we observed that this suppression enhances the reaction uniformity among particles and homogenizes mechanical degradation, albeit increasing pore formation and tortuosity. In addition, unbridled chemical degradation induces significant reaction heterogeneity and non-uniform mechanical degradation, with fewer pores and lower tortuosity. These findings complement the understanding of mechanical degradation, which is traditionally described using the metrics of contact loss and tortuosity, and underscore the critical role of coating layers in promoting lithium conduction by maintaining contact with the cathode surface.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"42 1","pages":"8838"},"PeriodicalIF":16.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tellurium-assisted growth of large-scale atom-thin insulating amorphous carbon on insulating substrates. 碲辅助在绝缘衬底上生长大规模原子薄绝缘非晶碳。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-03 DOI: 10.1038/s41467-025-63872-7
Ya Deng,Zihao Wang,Zhili Hu,Ang Li,Xin Zhou,Zhaolong Chen,Xingli Wang,Jiawei Liu,Kongyang Yi,Dundong Yuan,Xiaowei Wang,Peikun Zhang,Chao Zhu,Xiaoxu Zhao,Wei Ma,Yao Wu,Ruihuan Duan,Qundong Fu,Jiefu Yang,Xiuxian Zhou,Mengyao Cao,Chao Zhu,Beng Kang Tay,Jian Zhang,Mickael Lucien Perrin,Wu Zhou,Zhuhua Zhang,Kostya S Novoselov,Zheng Liu
{"title":"Tellurium-assisted growth of large-scale atom-thin insulating amorphous carbon on insulating substrates.","authors":"Ya Deng,Zihao Wang,Zhili Hu,Ang Li,Xin Zhou,Zhaolong Chen,Xingli Wang,Jiawei Liu,Kongyang Yi,Dundong Yuan,Xiaowei Wang,Peikun Zhang,Chao Zhu,Xiaoxu Zhao,Wei Ma,Yao Wu,Ruihuan Duan,Qundong Fu,Jiefu Yang,Xiuxian Zhou,Mengyao Cao,Chao Zhu,Beng Kang Tay,Jian Zhang,Mickael Lucien Perrin,Wu Zhou,Zhuhua Zhang,Kostya S Novoselov,Zheng Liu","doi":"10.1038/s41467-025-63872-7","DOIUrl":"https://doi.org/10.1038/s41467-025-63872-7","url":null,"abstract":"Monolayer amorphous carbon (a-C), an atom-thin two-dimensional (2D) carbon amorphous material, has attracted significant attention due to its structural and transport properties. Here, we report a chemical vapor deposition (CVD) approach for directly synthesizing monolayer a-C films on insulating substrates, achieving high control over their size, thickness, and fabrication. The synthesized films exhibit a complete coverage over a 2-inch wafer, with high uniformity. Our theoretical analysis reveals the critical role of tellurium in promoting the growth of monolayer a-C on the substrate. Moreover, quantum tunneling measurements at liquid helium temperature were conducted on the a-C films, confirming the samples' homogeneity and their insulating behavior. This work provides a promising strategy for direct synthesis of atom-thin insulating amorphous materials and deepens our understanding of quantum phenomena and electronic properties in low-dimensional disordered materials.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"105 1","pages":"8824"},"PeriodicalIF":16.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity. 核膜蛋白LEMD3组织三维染色质结构以维持血管平滑肌细胞的身份。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-03 DOI: 10.1038/s41467-025-63876-3
Wenqiang Li,Yunxi Liao,Zhujiang Liu,Longjian Niu,Jiaqi Huang,Yiting Jia,Ran Xu,Sudun Guan,Zhenhui Liang,Yiran Li,Hao Wu,Shirong Zhu,Liao Tan,Fang Yu,Zhihua Wang,Luyang Sun,Dongyu Zhao,Wei Kong,Yi Fu
{"title":"The inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity.","authors":"Wenqiang Li,Yunxi Liao,Zhujiang Liu,Longjian Niu,Jiaqi Huang,Yiting Jia,Ran Xu,Sudun Guan,Zhenhui Liang,Yiran Li,Hao Wu,Shirong Zhu,Liao Tan,Fang Yu,Zhihua Wang,Luyang Sun,Dongyu Zhao,Wei Kong,Yi Fu","doi":"10.1038/s41467-025-63876-3","DOIUrl":"https://doi.org/10.1038/s41467-025-63876-3","url":null,"abstract":"Maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) is critical for vascular homeostasis. However, the role of the 3D chromatin architecture in regulating VSMC identity remains elusive. A genome-scale CRISPR screen identifies LEMD3 as a potential regulator to maintain VSMC identity. Lemd3 deficiency in VSMCs results in the loss of the contractile phenotype and exacerbates intimal hyperplasia in mice. Protein interactome analysis reveals that LEMD3 interacts with CBX3, a principal reader of H3K9me2/3, subsequently anchoring heterochromatin at the nuclear periphery. Employing the DNA polymer model based on Hi-C data, whole-chromosome simulations demonstrate that Lemd3 depletion disturbs the chromatin structure. Multi-omics analysis further reveals that Lemd3 depletion alters the genome conformation as the increase of inter-TAD (topologically associated domain) interactions at the boundaries of A and B compartments, which correlates with decreased chromatin accessibility and repressed expression of VSMC contractile genes. This study reveals that LEMD3 organizes the 3D chromatin architecture by anchoring heterochromatin at the nuclear periphery to maintain the VSMC contractile identity.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"78 1","pages":"8826"},"PeriodicalIF":16.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular insights into how the motions of the β-barrel and POTRA domains of BamA are coupled for efficient function. BamA的β-桶和POTRA结构域的运动如何耦合以实现有效功能的分子见解。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-03 DOI: 10.1038/s41467-025-63897-y
Naemi Csoma,Jonathan M Machin,James M Whitehouse,Raquel Rodrìguez-Alonso,Monika Olejnik,Adam K Cahill,Seung-Hyun Cho,Till F Schäberle,Bogdan I Iorga,Neil A Ranson,Sheena E Radford,Antonio N Calabrese,Jean-François Collet
{"title":"Molecular insights into how the motions of the β-barrel and POTRA domains of BamA are coupled for efficient function.","authors":"Naemi Csoma,Jonathan M Machin,James M Whitehouse,Raquel Rodrìguez-Alonso,Monika Olejnik,Adam K Cahill,Seung-Hyun Cho,Till F Schäberle,Bogdan I Iorga,Neil A Ranson,Sheena E Radford,Antonio N Calabrese,Jean-François Collet","doi":"10.1038/s41467-025-63897-y","DOIUrl":"https://doi.org/10.1038/s41467-025-63897-y","url":null,"abstract":"The β-barrel assembly machinery (BAM) inserts β-barrel proteins into the outer membrane of Gram-negative bacteria, forming an essential permeability barrier. The core BAM component, BamA, is a β-barrel protein with an N-terminal periplasmic extension comprising five polypeptide transport-associated (POTRA) domains. Whilst BamA's structure is well characterised, it remains unclear how β-barrel and POTRA domain motions are coordinated. Using BamA variants with mutations in the hinge region between these two domains, we demonstrate that hinge flexibility is required for BAM function. Cryo-electron microscopy suggests that hinge rigidity impairs function by structurally decoupling these domains. A screen for spontaneous suppressors identified a mutation at position T434 in an extracellular loop of BamA, which has been previously shown to suppress BAM defects. Studying this variant provides insights into its function as a general rescue mechanism. Our findings underscore how BamA's sequence has been evolutionarily optimised for efficient function.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"55 1","pages":"8832"},"PeriodicalIF":16.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Observation of multiple time crystals in a driven-dissipative system with Rydberg gas. 里德伯气体驱动耗散系统中多时间晶体的观察。
IF 16.6 1区 综合性期刊
Nature Communications Pub Date : 2025-10-03 DOI: 10.1038/s41467-025-64488-7
Yuechun Jiao,Weilun Jiang,Yu Zhang,Jingxu Bai,Yunhui He,Heng Shen,Jianming Zhao,Suotang Jia
{"title":"Observation of multiple time crystals in a driven-dissipative system with Rydberg gas.","authors":"Yuechun Jiao,Weilun Jiang,Yu Zhang,Jingxu Bai,Yunhui He,Heng Shen,Jianming Zhao,Suotang Jia","doi":"10.1038/s41467-025-64488-7","DOIUrl":"https://doi.org/10.1038/s41467-025-64488-7","url":null,"abstract":"Time crystals, as temporal analogs of space crystals, manifest as stable and periodic behavior that breaks time translation symmetry. In an open quantum system, many-body interaction subjected to dissipation allows one to develop the time crystalline order in an unprecedented way, as refer to dissipative time crystals. Here we report the observation of multiple time crystals in the continuously driven-dissipative and strongly interacting Rydberg thermal gases, in which continuous time crystals, sub-harmonic time crystals and high-harmonic time crystals are observed in the same system by manipulating the Rydberg excitation. Our work provides new ways to explore the non-equilibrium phases of matter in open systems. Such time crystals with persistent oscillation rooted in emergent quantum correlations, may emerge as a ubiquitous tool in quantum metrology, for instance, continuous sensing and parameter estimation surpassing the standard quantum limit.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"22 1","pages":"8767"},"PeriodicalIF":16.6,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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