Ji-Ye Huang, Yu-Xin Jin, Wan-Ying Dong, Wan Zhao, Ping-Kai Cheng, Jun-Hao Miao, An Liu, Di Wang, Juan Li, Zhi Zhang, Wenjuan Tao, Xia Zhu
{"title":"Intra-somatosensory cortical circuits mediating pain-induced analgesia","authors":"Ji-Ye Huang, Yu-Xin Jin, Wan-Ying Dong, Wan Zhao, Ping-Kai Cheng, Jun-Hao Miao, An Liu, Di Wang, Juan Li, Zhi Zhang, Wenjuan Tao, Xia Zhu","doi":"10.1038/s41467-025-57050-y","DOIUrl":"https://doi.org/10.1038/s41467-025-57050-y","url":null,"abstract":"<p>Pain in one part of the body profoundly diminishes the sensation of pain in other parts of the body in humans. Here, we found that pain-related behaviors in hindpaw are inhibited by noxious stimuli from diverse body regions in mice. Using activity-dependent cell labeling in male <i>Fos</i><sup><i>TRAP2</i></sup> mice, we captured a neuronal ensemble in the layers 2–4 of secondary somatosensory cortex (S2) that was activated during pain at diverse body regions induced analgesia. Single-cell projection analysis showed that these S2 neurons receive projections from the contralateral S2 and specifically innervate the layer 4 of primary somatosensory cortex (S1). Microendoscopic calcium imaging and chemogenetic manipulation in freely moving mice showed that this S2 → S1 feedforward inhibitory circuit mediates ipsilateral pain-induced analgesia, whereas contralateral S2 innervation of the S2 → S1 circuit mediates contralateral pain-induced analgesia. Our study defines the intra-somatosensory cortical circuits underlying “pain inhibiting pain”, expanding the scope of known circuit mechanisms involved in pain relief.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"26 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephen E. White, Tristin A. Schwartze, Ananya Mukundan, Christina Schoenherr, Shashi P. Singh, Maarten van Dinther, Kyle T. Cunningham, Madeleine P. J. White, Tiffany Campion, John Pritchard, Cynthia S. Hinck, Peter ten Dijke, Gareth J. Inman, Rick M. Maizels, Andrew P. Hinck
{"title":"TGM6 is a helminth secretory product that mimics TGF-β binding to TGFBR2 to antagonize signaling in fibroblasts","authors":"Stephen E. White, Tristin A. Schwartze, Ananya Mukundan, Christina Schoenherr, Shashi P. Singh, Maarten van Dinther, Kyle T. Cunningham, Madeleine P. J. White, Tiffany Campion, John Pritchard, Cynthia S. Hinck, Peter ten Dijke, Gareth J. Inman, Rick M. Maizels, Andrew P. Hinck","doi":"10.1038/s41467-025-56954-z","DOIUrl":"https://doi.org/10.1038/s41467-025-56954-z","url":null,"abstract":"<p>TGM6 is a natural antagonist of mammalian TGF-β signaling produced by the murine helminth parasite <i>Heligmosomoides polygyrus</i>. It differs from the previously described agonist, TGM1 (TGF-β Mimic-1), in that it lacks domains 1/2 that bind TGFBR1. It nonetheless retains TGFBR2 binding through domain 3 and potently inhibits TGF-β signaling in fibroblasts and epithelial cells, but does not inhibit TGF-β signaling in T cells, consistent with divergent domains 4/5 and an altered co-receptor binding preference. The crystal structure of TGM6 bound to TGFBR2 reveals an interface remarkably similar to that of TGF-β with TGFBR2. Thus, TGM6 has adapted its structure to mimic TGF-β, while engaging a distinct co-receptor to direct antagonism to fibroblasts and epithelial cells. The co-expression of TGM6, along with immunosuppressive TGMs that activate the TGF-β pathway, may minimize fibrotic damage to the host as the parasite progresses through its life cycle from the intestinal lumen to submucosa and back again. The co-receptor-dependent targeting of TGFBR2 by the parasite provides a template for the development of therapies for targeting the cancer- and fibrosis-promoting activities of the TGF-βs in humans.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"58 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Entanglement growth from squeezing on the MPS manifold","authors":"Sebastian Leontica, Andrew G. Green","doi":"10.1038/s41467-025-56959-8","DOIUrl":"https://doi.org/10.1038/s41467-025-56959-8","url":null,"abstract":"<p>Finding suitable characterizations of quantum chaos is a major challenge in many-body physics, with a central difficulty posed by the linearity of the Schrödinger equation. A possible solution for recovering non-linearity is to project the dynamics onto some variational manifold. The classical chaos induced via this procedure may be used as a signature of quantum chaos in the full Hilbert space. Here, we demonstrate analytically a previously heuristic connection between the Lyapunov spectrum from projection onto the matrix product state (MPS) manifold and the growth of entanglement. This growth occurs by squeezing a localized distribution on the variational manifold. The process qualitatively resembles the Cardy-Calabrese picture, where local perturbations to a moving MPS reference are interpreted as bosonic quasi-particles. Taking careful account of the number of distinct channels for these processes recovers the connection to the Lyapunov spectrum. Our results rigorously establish the physical significance of the projected Lyapunov spectrum, suggesting it as an alternative method of characterizing chaos in quantum many-body systems, one that is manifestly linked to classical chaos.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"37 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Baihan Wang, Alfred Pozarickij, Mohsen Mazidi, Neil Wright, Pang Yao, Saredo Said, Andri Iona, Christiana Kartsonaki, Hannah Fry, Kuang Lin, Yiping Chen, Huaidong Du, Daniel Avery, Dan Schmidt-Valle, Canqing Yu, Dianjianyi Sun, Jun Lv, Michael Hill, Liming Li, Derrick A. Bennett, Rory Collins, Robin G. Walters, Robert Clarke, Iona Y. Millwood, Zhengming Chen
{"title":"Comparative studies of 2168 plasma proteins measured by two affinity-based platforms in 4000 Chinese adults","authors":"Baihan Wang, Alfred Pozarickij, Mohsen Mazidi, Neil Wright, Pang Yao, Saredo Said, Andri Iona, Christiana Kartsonaki, Hannah Fry, Kuang Lin, Yiping Chen, Huaidong Du, Daniel Avery, Dan Schmidt-Valle, Canqing Yu, Dianjianyi Sun, Jun Lv, Michael Hill, Liming Li, Derrick A. Bennett, Rory Collins, Robin G. Walters, Robert Clarke, Iona Y. Millwood, Zhengming Chen","doi":"10.1038/s41467-025-56935-2","DOIUrl":"https://doi.org/10.1038/s41467-025-56935-2","url":null,"abstract":"<p>Proteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured plasma levels of 2168 proteins in 3976 Chinese adults using both Olink Explore and SomaScan platforms. The correlation of protein levels between platforms was modest (median rho = 0.29), with protein abundance and data quality parameters being key factors influencing correlation. For 1694 proteins with one-to-one matched reagents, 765 Olink and 513 SomaScan proteins had <i>cis</i>-pQTLs, including 400 with colocalising <i>cis</i>-pQTLs. Moreover, 1096 Olink and 1429 SomaScan proteins were associated with BMI, while 279 and 154 proteins were associated with risk of ischaemic heart disease, respectively. Addition of Olink and SomaScan proteins to conventional risk factors for ischaemic heart disease improved C-statistics from 0.845 to 0.862 (NRI: 12.2%) and 0.863 (NRI: 16.4%), respectively. These results demonstrate the utility of these platforms and could inform the design and interpretation of future studies.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"12 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuyuan Chen, Rachel Putnik, Xi Li, Alka Diwaker, Marina Vasconcelos, Shuzhen Liu, Sudershan Gondi, Junhui Zhou, Lei Guo, Lin Xu, Sebastian Temme, Klare Bersch, Stephen Hyland, Jianyi Yin, Ezra Burstein, Brian J. Bahnson, Jeffrey C. Gildersleeve, Catherine Leimkuhler Grimes, Hans-Christian Reinecker
{"title":"PGLYRP1-mediated intracellular peptidoglycan detection promotes intestinal mucosal protection","authors":"Shuyuan Chen, Rachel Putnik, Xi Li, Alka Diwaker, Marina Vasconcelos, Shuzhen Liu, Sudershan Gondi, Junhui Zhou, Lei Guo, Lin Xu, Sebastian Temme, Klare Bersch, Stephen Hyland, Jianyi Yin, Ezra Burstein, Brian J. Bahnson, Jeffrey C. Gildersleeve, Catherine Leimkuhler Grimes, Hans-Christian Reinecker","doi":"10.1038/s41467-025-57126-9","DOIUrl":"https://doi.org/10.1038/s41467-025-57126-9","url":null,"abstract":"<p>Peptidoglycan recognition proteins (PGLYRPs) are implicated in the control of the intestinal microbiota; however, molecular requirements for peptidoglycan (PGN) binding and receptor signaling mechanisms remain poorly understood. Here we show that PGLYRP1 is a receptor for the disaccharide motif of lysine N-acetylglucosamine N-acetylmuramic tripeptide (GMTriP-K). PGLYRP1 is required for innate immune activation by GMTriP-K but not muramyl dipeptide (MDP). In macrophages, intracellular PGLYRP1 complexes with NOD2 and GEF-H1, both of which are required for GMTriP-K-regulated gene expression. PGLYRP1 localizes to the endoplasmic reticulum and interacts at the Golgi with NOD2 upon GMTriP-K stimulation. PGLYRP1 and dependent gene expression signatures are induced in both mouse intestinal inflammation and human ulcerative colitis. Importantly, PGLYRP1 activation by GMTriP-K can result in the protection of mice from TNBS-induced colitis. Mammalian PGLYRPs can function as intracellular pattern recognition receptors for the control of host defense responses in the intestine.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"50 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jinjin Yu, Yingke Li, Yiming Li, Xiaotian Liu, Qingyang Huo, Nan Wu, Yangxia Zhang, Taoling Zeng, Yong Zhang, Henry You Li, Jie Lian, Jihong Zhou, Emmanuel Jairaj Moses, Jian Geng, Juntang Lin, Wei Li, Xinxing Zhu
{"title":"Phosphorylation of FOXN3 by NEK6 promotes pulmonary fibrosis through Smad signaling","authors":"Jinjin Yu, Yingke Li, Yiming Li, Xiaotian Liu, Qingyang Huo, Nan Wu, Yangxia Zhang, Taoling Zeng, Yong Zhang, Henry You Li, Jie Lian, Jihong Zhou, Emmanuel Jairaj Moses, Jian Geng, Juntang Lin, Wei Li, Xinxing Zhu","doi":"10.1038/s41467-025-56922-7","DOIUrl":"https://doi.org/10.1038/s41467-025-56922-7","url":null,"abstract":"<p>The transcriptional repressor FOXN3 plays a key role in regulating pulmonary inflammatory responses, which are crucial in the development of pulmonary fibrosis. However, its specific regulatory function in lung fibrosis remains unclear. Here, we show that FOXN3 suppresses pulmonary fibrosis by inhibiting Smad transcriptional activity. FOXN3 targets a substantial number of Smad response gene promoters, facilitating Smad4 ubiquitination, which disrupts the association of the Smad2/3/4 complex with chromatin and abolishes its transcriptional response. In response to pro-fibrotic stimuli, NEK6 phosphorylates FOXN3 at S412 and S416, leading to its degradation. The loss of FOXN3 inhibits β-TrCP-mediated ubiquitination of Smad4, stabilizing the Smad complex’s association with its responsive elements and promoting transcriptional activation, thus contributing to the development of pulmonary fibrosis. Notably, we found a significant inverse expression pattern between FOXN3 and Smad4 in clinical pulmonary fibrosis cases, underscoring the importance of the NEK6-FOXN3-Smad axis in the pathological process of pulmonary fibrosis.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"179 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Georgina A. Stooke-Vaughan, Sangwoo Kim, Shuo-Ting Yen, Kevin Son, Samhita P. Banavar, James Giammona, David Kimelman, Otger Campàs
{"title":"The physical roles of different posterior tissues in zebrafish axis elongation","authors":"Georgina A. Stooke-Vaughan, Sangwoo Kim, Shuo-Ting Yen, Kevin Son, Samhita P. Banavar, James Giammona, David Kimelman, Otger Campàs","doi":"10.1038/s41467-025-56334-7","DOIUrl":"https://doi.org/10.1038/s41467-025-56334-7","url":null,"abstract":"<p>Shaping embryonic tissues requires spatiotemporal changes in genetic and signaling activity as well as in tissue mechanics. Studies linking specific molecular perturbations to changes in the tissue physical state remain sparse. Here we study how specific genetic perturbations affecting different posterior tissues during zebrafish body axis elongation change their physical state, the resulting large-scale tissue flows, and posterior elongation. Using a custom analysis software to reveal spatiotemporal variations in tissue fluidity, we show that dorsal tissues are most fluid at the posterior end, rigidify anterior of this region, and become more fluid again yet further anteriorly. In the absence of notochord (<i>noto</i> mutants) or when the presomitic mesoderm is substantially reduced (<i>tbx16</i> mutants), dorsal tissues elongate normally. Perturbations of posterior-directed morphogenetic flows in dorsal tissues (<i>vangl2</i> mutants) strongly affect the speed of elongation, highlighting the essential role of dorsal cell flows in delivering the necessary material to elongate the axis.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"50 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrew S. Lee, Tanzil M. Arefin, Alina Gubanova, Daniel N. Stephen, Yu Liu, Zhimin Lao, Anjana Krishnamurthy, Natalia V. De Marco García, Detlef H. Heck, Jiangyang Zhang, Anjali M. Rajadhyaksha, Alexandra L. Joyner
{"title":"Cerebellar output neurons can impair non-motor behaviors by altering development of extracerebellar connectivity","authors":"Andrew S. Lee, Tanzil M. Arefin, Alina Gubanova, Daniel N. Stephen, Yu Liu, Zhimin Lao, Anjana Krishnamurthy, Natalia V. De Marco García, Detlef H. Heck, Jiangyang Zhang, Anjali M. Rajadhyaksha, Alexandra L. Joyner","doi":"10.1038/s41467-025-57080-6","DOIUrl":"https://doi.org/10.1038/s41467-025-57080-6","url":null,"abstract":"<p>The capacity of the brain to compensate for insults during development depends on the type of cell loss, whereas the consequences of genetic mutations in the same neurons are difficult to predict. We reveal powerful compensation from outside the mouse cerebellum when the excitatory cerebellar output neurons are ablated embryonically and demonstrate that the main requirement for these neurons is for motor coordination and not basic learning and social behaviors. In contrast, loss of the homeobox transcription factors Engrailed1/2 (EN1/2) in the cerebellar excitatory lineage leads to additional deficits in adult learning and spatial working memory, despite half of the excitatory output neurons being intact. Diffusion MRI indicates increased thalamo-cortico-striatal connectivity in <i>En1/2</i> mutants, showing that the remaining excitatory neurons lacking <i>En1/2</i> exert adverse effects on extracerebellar circuits regulating motor learning and select non-motor behaviors. Thus, an absence of cerebellar output neurons is less disruptive than having cerebellar genetic mutations.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"82 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yaqi Ma, Meizhen Huang, Xu Zhang, Weixiong Hu, Zishu Zhou, Kai Feng, Wenhui Li, Yong Chen, Chenxuan Lou, Weikang Zhang, Haoxi Ji, Yibo Wang, Zefei Wu, Xiaodong Cui, Wang Yao, Shichao Yan, Zi Yang Meng, Ning Wang
{"title":"Magnetic Bloch states at integer flux quanta induced by super-moiré potential in graphene aligned with twisted boron nitride","authors":"Yaqi Ma, Meizhen Huang, Xu Zhang, Weixiong Hu, Zishu Zhou, Kai Feng, Wenhui Li, Yong Chen, Chenxuan Lou, Weikang Zhang, Haoxi Ji, Yibo Wang, Zefei Wu, Xiaodong Cui, Wang Yao, Shichao Yan, Zi Yang Meng, Ning Wang","doi":"10.1038/s41467-025-57111-2","DOIUrl":"https://doi.org/10.1038/s41467-025-57111-2","url":null,"abstract":"<p>Two-dimensional electron systems in both magnetic fields and periodic potentials are described by the Hofstadter butterfly, a fundamental problem of solid-state physics. While moiré systems provide a powerful method to realize this type of spectrum, previous experiments have been limited to fractional flux quanta regime, due to the difficulty of building ~ 50 nm periodic modulations. Here, we demonstrate a super-moiré strategy to overcome this challenge. By aligning monolayer graphene (G) with 1.0° twisted hexagonal boron nitride (t-hBN), a 63.2 nm bichromatic G/t-hBN super-moiré is constructed, made possible by exploiting the electrostatic nature of t-hBN potential. Under magnetic field <span>(B)</span>, magnetic Bloch states at <span>(phi /{phi }_{0}=1-9)</span> are achieved and observed as integer Brown-Zak oscillations, expanding the flux quanta from fractions to integers. Theoretical analysis reproduces these experimental findings. This work opens promising avenues to study unexplored Hofstadter butterfly, explore emergent topological order at integer flux quanta and engineer long-wavelength periodic modulations.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"82 2 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhi-Hao Cui, Junjie Yang, Johannes Tölle, Hong-Zhou Ye, Shunyue Yuan, Huanchen Zhai, Gunhee Park, Raehyun Kim, Xing Zhang, Lin Lin, Timothy C. Berkelbach, Garnet Kin-Lic Chan
{"title":"Ab initio quantum many-body description of superconducting trends in the cuprates","authors":"Zhi-Hao Cui, Junjie Yang, Johannes Tölle, Hong-Zhou Ye, Shunyue Yuan, Huanchen Zhai, Gunhee Park, Raehyun Kim, Xing Zhang, Lin Lin, Timothy C. Berkelbach, Garnet Kin-Lic Chan","doi":"10.1038/s41467-025-56883-x","DOIUrl":"https://doi.org/10.1038/s41467-025-56883-x","url":null,"abstract":"<p>Using a systematic ab initio quantum many-body approach that goes beyond low-energy models, we directly compute the superconducting pairing order and estimate the pairing gap of several doped cuprate materials and structures within a purely electronic picture. We find that we can correctly capture two well-known trends: the pressure effect, where the pairing order and gap increase with intra-layer pressure, and the layer effect, where the pairing order and gap vary with the number of copper-oxygen layers. From these calculations, we observe that the strength of superexchange and the covalency at optimal doping are the best descriptors for these trends. Our microscopic analysis further identifies that strong short-range spin fluctuations and multi-orbital charge fluctuations drive the development of the pairing order. Our work illustrates the possibility of a material-specific ab initio understanding of unconventional high-temperature superconducting materials.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"50 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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