Nature Communications最新文献_第3页

A synaptic mitochondrion–ribbon–vesicle complex organizes photoreceptor neurotransmission 突触线粒体-带状-囊泡复合体组织光感受器神经传递

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-78869-z

Fenglan Wang, Wenna Zhao, Xin Lin, Xiaotian Bian, Qingwen Yang, Zhongqun Chen, Fang He, Xiaoqing Liu, Xi Yu, Bilin Rao, Jun Cao, Jia Qu, Jun Zhang

{"title":"A synaptic mitochondrion–ribbon–vesicle complex organizes photoreceptor neurotransmission","authors":"Fenglan Wang, Wenna Zhao, Xin Lin, Xiaotian Bian, Qingwen Yang, Zhongqun Chen, Fang He, Xiaoqing Liu, Xi Yu, Bilin Rao, Jun Cao, Jia Qu, Jun Zhang","doi":"10.1038/s41467-026-78869-z","DOIUrl":"https://doi.org/10.1038/s41467-026-78869-z","url":null,"abstract":"Photoreceptor synapses rely on mitochondria, synaptic ribbons, and vesicles, yet how these elements integrate into functional units remains unclear. Here we show, using focused ion beam-scanning electron microscopy (FIB-SEM) and electrophysiology, that they form synaptic mitochondrion–ribbon–vesicle complexes (sMRVcs) with fundamentally different architectures in rods and cones. Rod spherules exhibit a strict 1:1 pairing of a single megamitochondrion with one ribbon, sustaining continuous glutamate release in darkness, whereas cone pedicles contain multiple distributed sMRVcs. Disrupting the mitochondrial anchor protein syntaphilin shifts this ratio to 2:1 in rods, with additional mitochondria recruited near the ribbon, and enhances synaptic transmission. In a retinal degeneration model, the sMRVc progressively disassembles before functional decline, with fragmented mitochondria, detached ribbons, and dispersed vesicles. We also identify non-ribbon release sites selectively targeting horizontal cells. These findings establish the sMRVc as a conserved structural–metabolic module whose subtype-specific organization reflects distinct visual demands and whose integrity is essential for synaptic health.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic and multi-omic insights into inflammation and metabolism in a French Polynesian cohort 法属波利尼西亚队列中炎症和代谢的遗传和多组学见解

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-78816-y

Tristan Pascart, Iman Hamid, Anne-Katrin Emde, Olivia A. Gray, Jaye Moors, Baptiste Gérard, Melissa Hendershott, Sarah LeBaron von Baeyer, Vehia Wheeler, Mathilde Boissel, Erwan Oehler, Valérie Chune, Thomas Bardin, Cristian Preda, Megan Leask, Laura Yerges-Armstrong, Kaja A. Wasik, Keolu Fox, Tony R. Merriman, Stephane E. Castel

{"title":"Genetic and multi-omic insights into inflammation and metabolism in a French Polynesian cohort","authors":"Tristan Pascart, Iman Hamid, Anne-Katrin Emde, Olivia A. Gray, Jaye Moors, Baptiste Gérard, Melissa Hendershott, Sarah LeBaron von Baeyer, Vehia Wheeler, Mathilde Boissel, Erwan Oehler, Valérie Chune, Thomas Bardin, Cristian Preda, Megan Leask, Laura Yerges-Armstrong, Kaja A. Wasik, Keolu Fox, Tony R. Merriman, Stephane E. Castel","doi":"10.1038/s41467-026-78816-y","DOIUrl":"https://doi.org/10.1038/s41467-026-78816-y","url":null,"abstract":"Inflammatory and metabolic diseases are a major global health burden, and their genetic mechanisms differ between populations. The stepwise settlement of the Pacific has left Polynesian communities with variants that are locally common and globally rare. Yet these communities remain underrepresented in genomic research. Here we combine whole-genome sequencing with blood metabolite and gene-activity profiling in a gout-focused cohort of 1,043 French Polynesian participants, and show that such variants shape molecular traits and disease risk. Hundreds alter metabolite levels, gene expression or splicing but are absent or rare in global reference datasets. Findings include a gene-disrupting variant in ANGPTL8 that lowers lipids and inflammatory markers; an LRMDA variant linked to type 2 diabetes; and a signal at the alpha-globin locus suggestive of thalassemia trait. Integrating molecular and phenotypic data further implicates WDR1 as an additional causal gout gene at the SLC2A9 locus. Genomic research in underrepresented populations thus reveals broadly relevant disease mechanisms.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"22 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural dynamics between Argonaute-2 and CK1α promote target RNA release in microRNA-mediated silencing Argonaute-2和CK1α之间的结构动力学促进了microrna介导的沉默中靶RNA的释放

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-78829-7

Ankur Garg, Leah Braviner, Armend Axhemi, Brianna Bibel, Leemor Joshua-Tor

{"title":"Structural dynamics between Argonaute-2 and CK1α promote target RNA release in microRNA-mediated silencing","authors":"Ankur Garg, Leah Braviner, Armend Axhemi, Brianna Bibel, Leemor Joshua-Tor","doi":"10.1038/s41467-026-78829-7","DOIUrl":"https://doi.org/10.1038/s41467-026-78829-7","url":null,"abstract":"Argonaute (Ago) proteins associate with 20-22 nucleotide (nt) long microRNAs (miRNAs) to constitute the functional RISC core and downregulate mRNAs containing complementarity to the seed sequence. Target RNA engagement in RISC stimulates CK1α-mediated phosphorylation of the conserved eukaryotic insertion (EI) in Ago, releasing the target and enabling the RISC complex to suppress additional target sites for efficient miRNA-mediated silencing. Here, we provide a complete structural view of miRNA guide and target binding to human Ago2, showing Ago2 holding the double-stranded guide-target RNA in an untwisted conformation at its center. We visualize the dynamic changes that RISC undergoes as the guide supplementary region progressively base pairs with the target, enabling CK1α binding. Following seed-helix assembly, initial supplementary pairing restricts RISC to a “closed” form, while with half-supplementary pairing, the PAZ domain moves to open RISC to become receptive to CK1α, exhibiting an initial increase in Ago2 phosphorylation. Complete supplementary pairing supports a full PAZ-CK1α interface, allowing for hierarchical phosphorylation of the EI. The combination of target repulsion by EI phosphorylation with an unwound guide-target enables efficient target release to promote RISC turnover.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metallaphotoredox-catalyzed ring swing of arene-fused cycles to γ-sultones 金属光氧化还原催化芳烃熔合环向γ-硫酮的摆动

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-79071-x

Tianyu He, Yi Duan, Qixin Jia, Yanju Lu, Xiaoxiang Zhang, Yan Zhao, Shenlin Huang

引用次数: 0

Recommendation system-inspired learning of crossmodal interaction patterns between chromatin accessibility and gene expression 推荐系统启发学习染色质可及性和基因表达之间的跨模态相互作用模式

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-78646-y

Xiaotang Wang, Xuanwei Lin, Qiaoyi Zhang, Xiaochen Bo, Hao Li, Yongqi Zhang

{"title":"Recommendation system-inspired learning of crossmodal interaction patterns between chromatin accessibility and gene expression","authors":"Xiaotang Wang, Xuanwei Lin, Qiaoyi Zhang, Xiaochen Bo, Hao Li, Yongqi Zhang","doi":"10.1038/s41467-026-78646-y","DOIUrl":"https://doi.org/10.1038/s41467-026-78646-y","url":null,"abstract":"Despite the growing availability of crossmodal single-cell sequencing, existing approaches are limited by underutilization of biological attributes, sparse modality signals, and insufficient modeling of regulatory interactions, limiting generalization in data-scarce settings and the discovery of peak-gene-level relationships. Interestingly, such challenges mirror those in recommendation systems, where side information, high sparsity, binary interactions, and cold start problems are extensively studied. Inspired by recommender models that infer user-item preferences from incomplete interaction graphs, we present CrossRec, which reformulates scATAC and scRNA data as an interaction graph to learn regulatory patterns across single-cell tasks. Its biologically-driven bipartite graph transformer learns interpretable attention over ATAC-RNA pairs. CrossRec outperforms existing methods across various tasks, remains robust under data-scarce settings, generalizes to unseen cell types and datasets, and enhances prior-based methods. Its learned regulatory maps provide cell- and cell-type-specific insights, resolving dynamic regulatory rewiring during cortical neurogenesis and perturbation-specific rewiring of drug-induced regulation in melanoma resistance.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"14 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A lightweight portable ultrasound robot for autonomous liver sonography 一种用于自主肝脏超声检查的轻型便携式超声机器人

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-79007-5

Zihan Li, Yixiao Xu, Lei Zhang, Taiyu Han, Xinshan Yang, Yingni Wang, Mingxuan Liu, Shenghai Xin, Linxun Liu, Hongen Liao, Guochen Ning

{"title":"A lightweight portable ultrasound robot for autonomous liver sonography","authors":"Zihan Li, Yixiao Xu, Lei Zhang, Taiyu Han, Xinshan Yang, Yingni Wang, Mingxuan Liu, Shenghai Xin, Linxun Liu, Hongen Liao, Guochen Ning","doi":"10.1038/s41467-026-79007-5","DOIUrl":"https://doi.org/10.1038/s41467-026-79007-5","url":null,"abstract":"Autonomous ultrasound robots could improve access to liver disease screening but remain limited by anatomical variability, respiratory motion and bulky hardware. Here, we present a lightweight robotic liver ultrasound system with a 588-g decoupled end-effector controlled by a sonographer-informed AI agent. The robot attaches directly to the abdomen, maintaining stable force and controlled motion during breathing and patient-side disturbances. Trained on sonographer trajectories, the agent integrates spatial, tactile and visual feedback to navigate discontinuous acoustic windows and acquire standard imaging planes. Evaluations in 102 healthy participants and 17 patients yielded clinically interpretable images and anatomical measurements closely matching clinical references. We also deployed the system for hepatic echinococcosis screening in a high-altitude, low-resource setting on the Qinghai-Tibet Plateau and evaluated its performance in dynamic scenarios, including vehicle-based scanning. These findings support portable, patient-mounted robotics for standardized ultrasound beyond specialist settings.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"290 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149242028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting protein electrostatics with protein language models 用蛋白质语言模型预测蛋白质静电

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-78406-y

Mingzhe Shen, Guy W. Dayhoff II, Daniel Kortzak, Jana Shen

{"title":"Predicting protein electrostatics with protein language models","authors":"Mingzhe Shen, Guy W. Dayhoff II, Daniel Kortzak, Jana Shen","doi":"10.1038/s41467-026-78406-y","DOIUrl":"https://doi.org/10.1038/s41467-026-78406-y","url":null,"abstract":"Ionization states are crucial to protein function, yet predicting their equilibrium constants remains challenging. Here we present KaML-ESMs, sequence-based neural networks built on the ESM protein language models and trained on the GAINES-augmented PKAD-3r dataset. KaML-ESM2/ESMC outperform alternative approaches across four benchmarks, achieving root-mean-square errors of about 0.5 units for Asp/Glu/His/Cys/Tyr/Lys residues in native proteins. Performance degrades on 89 buried engineered mutations lacking evolutionary support, revealing a limitation that supervised training may help overcome. These results suggest that protein sequence, through its evolutionary context, encodes not only structure and function but also, indirectly, electrostatic characteristics. Applying KaML-ESM2 to the entire human proteome, we show that predicted pKa values can identify functional sites and infer catalytic mechanisms. We offer KaML, a sequence-based pKa prediction platform supporting biological exploration, protein engineering, and biomolecular simulation. With further development, GAINES could provide a general framework for addressing data scarcity in machine learning.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"494 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Charge heterogenized PtFe clusters defy activity–selectivity trade-offs in propane dehydrogenation 电荷异质聚四氟乙烯簇无视丙烷脱氢活性选择性权衡

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-79089-1

Yicong Chai, Peng Li, Dali Chen, Lin Li, Xiaoli Pan, Lulu Chen, Xiaodong Wang, Sen Lin, Jian Lin, Xianzhi Fu, Tao Zhang

{"title":"Charge heterogenized PtFe clusters defy activity–selectivity trade-offs in propane dehydrogenation","authors":"Yicong Chai, Peng Li, Dali Chen, Lin Li, Xiaoli Pan, Lulu Chen, Xiaodong Wang, Sen Lin, Jian Lin, Xianzhi Fu, Tao Zhang","doi":"10.1038/s41467-026-79089-1","DOIUrl":"https://doi.org/10.1038/s41467-026-79089-1","url":null,"abstract":"Propane dehydrogenation is a pivotal industrial reaction, yet its efficiency is fundamentally constrained by the persistent scaling relation between propane activation and propylene desorption. Here, we transcend this compromise by deliberately constructing charge-state heterogeneity of silica-supported subnanometric PtFe clusters. Through synergistic Pt–Fe alloying and Pt–O–Fe interfacial bonding, we concurrently stabilize electron-rich (Ptδ−) and electron-deficient (Ptδ+) sites within a single catalytic ensemble. This architectural design enables the catalyst to achieve ~99% propylene selectivity at near-thermodynamic equilibrium conversion (~60% at 600 °C) with an ultralow Pt loading of 0.1 wt%, demonstrating high catalytic performance under reaction conditions. Mechanistic studies reveal that Ptδ− sites promote C–H bond cleavage via an electron-withdrawing effect that depletes σ-bond electron density, while neighboring Ptδ+ sites facilitate propylene desorption by modulating d–π orbital interactions. This work establishes charge-state heterogeneity as a versatile principle for circumventing scaling relations in catalytic alkane transformations.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"17 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coupled sea-level and biodiversity dynamics during the Cambrian SPICE event 寒武纪SPICE事件期间海平面与生物多样性的耦合动态

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-78601-x

Meng Wang (王蒙), Yukun Shi, Aihua Yang, Haotian Zhang, Xiaoyu Zhang, Yujing Wu, Yujie Shi, Jianbo Liu, Ren Wei, Zhijun Jin, Mingsong Li (李明松)

{"title":"Coupled sea-level and biodiversity dynamics during the Cambrian SPICE event","authors":"Meng Wang \u0000 (王蒙), Yukun Shi, Aihua Yang, Haotian Zhang, Xiaoyu Zhang, Yujing Wu, Yujie Shi, Jianbo Liu, Ren Wei, Zhijun Jin, Mingsong Li \u0000 (李明松)","doi":"10.1038/s41467-026-78601-x","DOIUrl":"https://doi.org/10.1038/s41467-026-78601-x","url":null,"abstract":"The prominent Cambrian Steptoean Positive Carbon Isotope Excursion (SPICE) stands as one of Earth’s largest carbon cycle perturbations, marked by widespread marine anoxia, climatic upheaval, and biotic turnover, yet the complete extent and interplay of these environmental changes remain unclear. Here, we integrate high-resolution astrochronology, carbonate carbon isotope records from the North China Block and marine species richness to investigate sedimentary and biogeochemical responses during the SPICE interval. Time series analysis reveals a distinct ~2-million-year sedimentary rhythm that aligns with cycles in reconstructed sea-level fluctuations and biodiversity dynamics. We show that sea-level changes preceded shifts in benthic species richness by 70 kyr, linking astronomically paced eustatic oscillations to marine redox fluctuations and concurrent biodiversity turnover. These findings establish pivotal constraints on ocean-climate interactions during this critical interval, elucidating Earth system resilience to extreme climatic and biogeochemical perturbations.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"66 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutualistic microbes linked to broader niches but reduced diversification 共生微生物与更广泛的生态位相关，但多样性降低

IF 16.6 1区综合性期刊

Nature Communications Pub Date : 2026-10-24 DOI: 10.1038/s41467-026-79030-6

Eleanor M. Hay, Rosana Zenil-Ferguson, Michelle E. Afkhami, Christopher A. Searcy

{"title":"Mutualistic microbes linked to broader niches but reduced diversification","authors":"Eleanor M. Hay, Rosana Zenil-Ferguson, Michelle E. Afkhami, Christopher A. Searcy","doi":"10.1038/s41467-026-79030-6","DOIUrl":"https://doi.org/10.1038/s41467-026-79030-6","url":null,"abstract":"Mutualistic interactions are widely hypothesized to broaden ecological niches and promote diversification, yet evidence for this relationship at macroevolutionary scales remains limited. Here, we investigate how fungal seed endophytes (Epichloë) influence niche breadth and diversification across over 100 species of the globally-distributed grass genus Poa. Combining global-scale climate, environmental, phylogenetic, and symbiosis data, we construct species distribution models for suites of symbiotic and non-symbiotic plant species, and use phylogenetic comparative methods to assess the influence of these symbionts on niche breadth, niche breadth evolution, and diversification. Endophyte-positive species have ~1.4 times broader primary niche axes (most often associated with temperature tolerances), ~2.5 times larger geographic ranges, and >30 times faster rates of niche breadth evolution than non-symbiotic species. Endophytic plants also have significantly drier climate centroids, consistent with endophyte-mediated drought tolerance, while simultaneously showing constrained niche centroid evolution. Despite pronounced niche expansion, hidden state speciation and extinction models reveal two modes of diversification: endophytes decrease diversification rates in young lineages, and have a neutral effect in older lineages. Together, our results indicate that mutualists can be associated with broader niches without necessarily increasing diversification, highlighting a potential decoupling between niche expansion and diversification.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0