综合性期刊最新文献

{"title":"Aged neurons don't register energy need.","authors":"Deniz Bingul, Scott F Owen","doi":"10.1126/science.adu4935","DOIUrl":"https://doi.org/10.1126/science.adu4935","url":null,"abstract":"<p><p>Neuronal activity and mitochondrial gene expression become decoupled in aged mice.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6728","pages":"1349-1350"},"PeriodicalIF":44.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behind the scenes of Nature News and Views in 2024","authors":"","doi":"10.1038/d41586-024-04246-9","DOIUrl":"https://doi.org/10.1038/d41586-024-04246-9","url":null,"abstract":"Listen to our reporters’ podcast highlights of 2024.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"99 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"That Christmas jumper is a marvel of complicated physics","authors":"","doi":"10.1038/d41586-024-04173-9","DOIUrl":"https://doi.org/10.1038/d41586-024-04173-9","url":null,"abstract":"Models and experiments demonstrate what happens when a knitted fabric is deformed.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"83 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stem cells head to the clinic: treatments for cancer, diabetes and Parkinson’s disease could soon be here","authors":"","doi":"10.1038/d41586-024-04160-0","DOIUrl":"https://doi.org/10.1038/d41586-024-04160-0","url":null,"abstract":"More than 100 clinical trials put stem cells for regenerative medicine to the test. It’s a turning point for a field beset with ethical and political controversy.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"54 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Build your own receptor: modular system can be tailored to any antigen","authors":"","doi":"10.1038/d41586-024-04178-4","DOIUrl":"https://doi.org/10.1038/d41586-024-04178-4","url":null,"abstract":"PAGERs provide modular, customizable G-protein-coupled receptors for cell-signalling studies.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"21 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A wearable triboelectric impedance tomography system for noninvasive and dynamic imaging of biological tissues","authors":"Peng Yang, Zhaoqi Liu, Siyao Qin, Jun Hu, Songmei Yuan, Zhong Lin Wang, Xiangyu Chen","doi":"10.1126/sciadv.adr9139","DOIUrl":"https://doi.org/10.1126/sciadv.adr9139","url":null,"abstract":"Tissue imaging is usually captured by hospital-based nuclear magnetic resonance. Here, we present a wearable triboelectric impedance tomography (TIT) system for noninvasive imaging of various biological tissues. The imaging mechanism relies on the obtained impedance information from the different soft human tissues. A high-precision signal source is designed on the basis of a composite triboelectric nanogenerator, which exhibits a minimal total harmonic distortion of 0.03% and a peak output signal-to-noise ratio up to 120 decibels. The current density injected into human skin is around 79.58 milliamperes per square meter, far below the safety threshold for medical devices. The TIT system achieves time-resolved tomography of human limbs’ soft tissues, and many appealing functions can be realized by using this wearable system, including the observation of muscle movement, the motion intention recognition, and the identification of pathological changes of soft tissue. Hence, this TIT system with excellent biocompatibility can be integrated with various devices, such as medical-assistive exoskeletons and smart protective suit.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"56 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrient management offsets the effect of deoxygenation and warming on nitrous oxide emissions in a large US estuary","authors":"Weiyi Tang, Fei Da, John C. Tracey, Naomi Intrator, Moriah A. Kunes, Jenna A. Lee, Xianhui Sean Wan, Amal Jayakumar, Marjorie A. M. Friedrichs, Bess B. Ward","doi":"10.1126/sciadv.adq5014","DOIUrl":"https://doi.org/10.1126/sciadv.adq5014","url":null,"abstract":"Many estuaries experience eutrophication, deoxygenation and warming, with potential impacts on greenhouse gas emissions. However, the response of N <jats:sub>2</jats:sub> O production to these changes is poorly constrained. Here we applied nitrogen isotope tracer incubations to measure N <jats:sub>2</jats:sub> O production under experimentally manipulated changes in oxygen and temperature in the Chesapeake Bay—the largest estuary in the United States. N <jats:sub>2</jats:sub> O production more than doubled from nitrification and increased exponentially from denitrification when O <jats:sub>2</jats:sub> was decreased from &gt;20 to &lt;5 micromolar. Raising temperature from 15° to 35°C increased N <jats:sub>2</jats:sub> O production 2- to 10-fold. Developing a biogeochemical model by incorporating these responses, N <jats:sub>2</jats:sub> O emissions from the Chesapeake Bay were estimated to decrease from 157 to 140 Mg N year <jats:sup>−1</jats:sup> from 1986 to 2016 and further to 124 Mg N year <jats:sup>−1</jats:sup> in 2050. Although deoxygenation and warming stimulate N <jats:sub>2</jats:sub> O production, the modeled decrease in N <jats:sub>2</jats:sub> O emissions, attributed to decreased nutrient inputs, indicates the importance of nutrient management in curbing greenhouse gas emissions, potentially mitigating climate change.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"13 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limits to timescale dependence in erosion rates: Quantifying glacial and fluvial erosion across timescales","authors":"Joel A. Wilner, Bailey J. Nordin, Alexander Getraer, Rowan M. Gregoire, Mansa Krishna, Jiawen Li, Derek J. Pickell, Emma R. Rogers, Kalin T. McDannell, Marisa C. Palucis, C. Keller","doi":"10.1126/sciadv.adr2009","DOIUrl":"https://doi.org/10.1126/sciadv.adr2009","url":null,"abstract":"Earth’s topography and climate result from the competition between uplift and erosion, but it has been debated whether rivers or glaciers are more effective erosional agents. We present a global compilation of fluvial and glacial erosion rates alongside simple numerical experiments, which show that the “Sadler effect,” wherein geological rates show an inverse relationship with measurement timescale, comprises three distinct effects: a measurement thickness bias, a bias of erosion and redeposition, and a bias introduced by not observing quiescent intervals. Furthermore, we find that, globally, average glacial erosion rates exceed fluvial erosion rates through time by an order of magnitude, and that this difference cannot be explained by Sadlerian biases or by variations in hillslope, precipitation, or latitude. These findings support observations of increased erosion rates following Cenozoic cooling and glaciation, and reveal the importance of glacial erosion over millennial to orogenic timescales.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"4 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic phase transitions dictate the size effect and activity of supported gold catalysts","authors":"Lei Zhou, Xin-Pu Fu, Ruixing Wang, Cong-Xiao Wang, Feng Luo, Han Yan, Yang He, Chun-Jiang Jia, Jun Li, Jin-Cheng Liu","doi":"10.1126/sciadv.adr4145","DOIUrl":"https://doi.org/10.1126/sciadv.adr4145","url":null,"abstract":"The landmark discovery of gold catalysts has aroused substantial interest in heterogeneous catalysis, yet the catalytic mechanism remains elusive. For carbon monoxide oxidation on gold nanoparticles (NPs) supported on ceria surfaces, it is widely believed that carbon monoxide adsorbs on the gold particles, while the reaction occurs at the gold/ceria interface. Here, we have investigated the dynamic changes of supported gold NPs with various sizes in a carbon monoxide oxidation atmosphere using deep potential molecular dynamics simulations. Our results reveal that the structure of tiny gold particles in carbon monoxide atmospheres becomes highly disordered and undergoes phase transition. Such a liquid-like structure provides massive reactive sites, enabling facile carbon monoxide oxidation on the solid-state gold NP rather than just at the gold/ceria interface. This result is further corroborated by catalytic experiments. This work sheds light on both the size effects and activity in noble metal catalysis and provides insights for the design of more effective nanocatalysts.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"79 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1","authors":"Martín González-Fernández, Carmen Perry, Nora Merete Gerhards, Paola Francica, Sven Rottenberg","doi":"10.1073/pnas.2402849121","DOIUrl":"https://doi.org/10.1073/pnas.2402849121","url":null,"abstract":"Taxanes are frequently used anticancer drugs known to kill tumor cells by inducing mitotic aberrations and segregation defects. A defining feature of specific cancers, notably triple-negative breast cancer (TNBC) and particularly those deficient in BRCA1, is chromosomal instability (CIN). Here, we focused on understanding the mechanisms of docetaxel-induced cytotoxicity, especially in the context of BRCA1-deficient TNBC. Using functional genetic screens in CIN+ cells, we identified genes that mediate docetaxel response and found an interaction between Huntingtin (HTT) and BRCA1-associated protein-1 (BAP1). We employed <jats:italic>Brca1</jats:italic> <jats:sup>−/−</jats:sup> ; <jats:italic> p53 <jats:sup>−</jats:sup> </jats:italic> <jats:sup>/−</jats:sup> mammary tumor cells, derived from genetically engineered mouse tumors that closely mimic the human disease, to investigate the role of these genes in CIN+ BRCA1-deficient cells. Specifically, we observed that loss of HTT sensitizes CIN+ BRCA1-deficient mammary tumor cells to docetaxel by shortening mitotic spindle poles and increasing spindle multipolarity. In contrast, BAP1 depletion protected cells against these spindle aberrations by restoring spindle length and enhancing mitotic clustering of the extra centrosomes. In conclusion, our findings shed light on the roles of HTT and BAP1 in controlling mitotic spindle multipolarity and centrosome clustering, specifically in the absence of BRCA1. This affects the response to microtubule-targeting agents and suggests that further studies of the interaction of these genes with the mitotic spindle may provide useful insights into how to target CIN+ cells, particularly in the challenging therapeutic landscape of BRCA1-deficient TNBC.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"11 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142867590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}