综合性期刊最新文献

{"title":"Machine Learning-Based Diagnostic Model for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Using Routine Clinical Laboratory Parameters.","authors":"Youpeng Chen,Yabang Chen,Junquan Sun,Yifei Xie,Jiancai Lu,Enzhong Li,Qingqing Yang,Yu Guo,Jiana Zhang,Haojie Wu,Zhangkai J Cheng,Baoqing Sun","doi":"10.1111/nyas.70080","DOIUrl":"https://doi.org/10.1111/nyas.70080","url":null,"abstract":"Acute exacerbation of chronic obstructive pulmonary disease (COPD), or AECOPD, significantly increases disease burden yet lacks objective diagnostic criteria. We aimed to develop a machine learning model for AECOPD diagnosis using routine laboratory parameters. We analyzed records from 25,965 COPD patients at the First Affiliated Hospital of Guangzhou Medical University, with patients randomized 7:3 into training and test cohorts. We evaluated 113 model combinations from 12 machine learning algorithms, assessing performance through receiver operating characteristic analysis, calibration curves, and decision curve analysis. The generalized linear model boosting + random forest (glmBoost + RF) model demonstrated excellent diagnostic performance (training area under the curve [AUC] = 0.993, test AUC = 0.834) utilizing only nine variables: age, lymphocyte percentage, calcium, hemoglobin, eosinophil percentage, potassium, platelet distribution width, monocytes count, and mean corpuscular hemoglobin concentration. This streamlined model showed performance comparable to the more complex Lasso + RF model (48 variables) with superior clinical applicability. Both models exhibited excellent calibration performance (mean absolute error = 0.012-0.013) and maintained consistent performance across gender-stratified populations. A machine learning model utilizing nine routine clinical laboratory parameters effectively distinguishes AECOPD from stable COPD, providing an objective diagnostic tool applicable across diverse healthcare settings, particularly in resource-limited facilities.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"58 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolutionary history of stony corals suggests that some could be resilient to climate change.","authors":"","doi":"10.1038/d41586-025-03362-4","DOIUrl":"https://doi.org/10.1038/d41586-025-03362-4","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"25 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical Impact of Partitioning Position and Angle on Post-SPGJ Gastric Emptying.","authors":"Zhenmin Fan,Qiuliang Li,Fengyan Xu,Haiqiao Zhang,Xia Ye,Zhi Zheng,Jun Zhang","doi":"10.1111/nyas.70104","DOIUrl":"https://doi.org/10.1111/nyas.70104","url":null,"abstract":"Stomach-partitioning gastrojejunostomy (SPGJ) improves gastric-outlet obstruction outcomes, yet its biomechanical basis and geometric optimization remain unclear. Patient computed tomography (CT) data were used to reconstruct realistic SPGJ models. Computational fluid dynamics combined with a discrete phase model quantified velocity, wall pressure, particle-retention time, and velocity under systematic variations of partitioning position (distal, mid, and proximal), partitioning angle (5°, 15°, and 25°; left- or right-sided), and incision angle (60°, 75°, and 90°). Distal partitioning produced the lowest pressure drop and fastest emptying, whereas proximal partitioning channeled high-speed flow toward the pylorus and prolonged retention. A ∼15° partitioning angle balanced flow restriction and clearance; extreme unilateral angles either increased particle stasis (left-side) or slowed emptying despite reduced reflux (right-side). A vertical incision (90°) further decreased pressure losses and shortened mean retention relative to oblique cuts. SPGJ biomechanics are highly geometry-sensitive. Distal placement, a 15° partitioning angle, and a near-vertical incision collectively optimize flow, reduce lesion contact, and accelerate gastric emptying, providing quantitative guidance for patient-specific SPGJ design.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"53 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145338920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red palm olein biscuit supplementation modulates gut microbiota in vitamin A deficient rural Malaysian schoolchildren: a randomised controlled trial.","authors":"Pei Yee Tan,Radhika Loganathan,Soo Ching Lee,Syahirah Nadiah Mohd Johari,Kim-Tiu Teng,Kanga Rani Selvaduray,Yvonne Ai-Lian Lim","doi":"10.1038/s41467-025-64395-x","DOIUrl":"https://doi.org/10.1038/s41467-025-64395-x","url":null,"abstract":"Emerging evidence suggests a bidirectional relationship between vitamin A deficiency (VAD) and gut microbiota, with implications to host health. This double-blind randomised controlled trial (NCT03256123) aims to investigate the effects of 6-month red palm olein (RPO)-enriched biscuit supplementation on gut microbiota of 328 vitamin A-deficient primary schoolchildren (aged 8-12 years) in rural Malaysia, randomised to receive either RPO-enriched biscuits (experimental group, n = 145) or palm olein (PO)-enriched biscuits (control group, n = 183). Stool samples are collected at baseline, 3-month and 6-month of supplementation, and analysed using 16S rRNA gene sequencing. The primary outcome is the changes in gut microbiota composition, while secondary outcomes include alteration in gut microbiota diversity, correlations with blood biomarkers, and microbial network structure. Compared to the control group, the experimental group shows significant reductions in alpha diversity indices (e.g., observed ASVs and chao1, P < 0.001), and increased abundance of potentially beneficial gut bacteria, such as Anaerostipes, UCG-010 and Lachnospiraceae_NK4A136_group (Padj < 0.05), which also positively correlate with improvements in alpha-carotene, beta-carotene, alpha-tocopherol, packed cell volume, and mean corpuscular volume (Padj < 0.05). Microbial network analysis reveals that the experimental group exhibits a more cohesive and stable network, evidenced by higher average degree and clustering coefficient values, and lower average path lengths (P < 0.001). Our findings shed light on the potential of RPO-enriched biscuit supplementation in modulating gut microbiota in vitamin A-deficient children by enhancing microbial network cohesiveness and enriching potentially beneficial bacterial taxa which are linked to enhanced micronutrient and haematological outcomes. These findings lay a valuable foundation and expand the existing evidence base for understanding the relationship between provitamin A carotenoids and gut microbiota.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"1 1","pages":"9341"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural mechanism of the agonist binding on human TRPC3 channel.","authors":"Yikun Chen,Jiahe Zang,Wenjun Guo,Jiaxuan Xu,Miao Wei,Li Quan,Min Zhu,Xiaole Zhao,Hailin Peng,Yakun Wan,Lei Chen","doi":"10.1038/s41467-025-64435-6","DOIUrl":"https://doi.org/10.1038/s41467-025-64435-6","url":null,"abstract":"TRPC3/6/7 channels are cation channels that are directly activated by the second messenger diacylglycerol (DAG). These channels play crucial physiological roles and are implicated in various disease conditions; however, the binding mechanism of DAG to these channels remains incompletely understood. In this study, we present the structures of human TRPC3 in complex with DAG or synthetic activators, 4n and GSK1702934A. The structural analysis reveals that DAG binds at the L2 site, located near the pore on the extracellular side of TRPC3. Functional assays confirmed that the L2 site serves as the activating site for DAG. Notably, both 4n and GSK1702934A competitively bind to the same site, facilitating channel activation. Moreover, based on the pharmacophore identified from the DAG-bound structure, we found that monoacylglycerols (MAGs) are endogenous activators of TRPC3/6/7 channels, providing new insights into their regulatory mechanisms.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"140 1","pages":"9343"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-equilibrium demixing and dissolution of chiral coacervates via intrinsic catalysis.","authors":"Saurabh Gupta,Sangam Jha,Chiranjit Mahato,Dibyendu Das","doi":"10.1038/s41467-025-64444-5","DOIUrl":"https://doi.org/10.1038/s41467-025-64444-5","url":null,"abstract":"Membraneless organelles seen in extant biology leverage biochemical energy sources to realize intracellular non-equilibrium microcompartments. Constructing their synthetic mimics from small molecules can contribute towards our understanding of active phase separation and their role in the chemical emergence of compartments. Herein, we develop a model of synthetic membraneless organelles as non-equilibrium droplet phase and are accessed via homotypic interactions between small activated molecule and short peptide. The constituent short peptide's residues mimic hydrolase-like activity via covalent catalysis which leads to vacuolization and subsequent generation of the dissolved equilibrium phase as a function of time. Despite the short tetrameric sequence, the peptide residues help in demixing (phase separation) as well as catalysis which is critical for achieving such non-equilibrium behaviour. Importantly, the low molecular weight active coacervates behave like chiral microenvironment, which further promotes kinetic resolution in chemical transformations, thus mirroring the dynamic and functional attributes associated with complex membraneless organelles.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"101 1","pages":"9336"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci.","authors":"Cindy Im,Andrew R Raduski,Lauren J Mills,Kashi Raj Bhattarai,Robert J Mobley,Kelly R Barnett,Zhanni Lu,Kenneth Liao,Nathan Anderson,Rebecca A Johnson,Erica Langer,Anthony J Hooten,Alix E Seif,Kathrin M Bernt,Matthew Tsang,Brandon A Mamou,Luis Gil-de-Gómez,Julie A Wolfson,Danielle N Friedman,Neerav Shukla,Laura J Klesse,Erin L Marcotte,Lingyun Ji,Alice Dang,Minjie Luo,Yiming Zhong,Jalen Langie,Charleston W K Chiang,Adam de Smith,Joseph L Wiemels,Andrew DeWan,Xiaomei Ma,Catherine Metayer,Zhaoming Wang,Heather H Nelson,Nathan Pankratz,Tianzhong Yang,Saonli Basu,Lucie M Turcotte,Jun J Yang,Daniel Savic,Michael E Scheurer,Logan G Spector","doi":"10.1038/s41467-025-64337-7","DOIUrl":"https://doi.org/10.1038/s41467-025-64337-7","url":null,"abstract":"B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric malignancy. Given racial/ethnic differences in incidence and outcomes, B-ALL genome-wide association studies among children of African ancestry are needed. Leveraging multi-institutional datasets with 840 African American children with B-ALL and 3360 controls, nine loci achieved genome-wide significance (P < 5 × 10-8) after meta-analysis. Two loci were established trans-ancestral susceptibility regions (IKZF1, ARID5B), while the remaining novel loci were specific to African populations. Five-year overall survival among children carrying novel risk alleles was significantly worse (83% versus 96% in non-carriers, P = 4.8 × 10-3). Novel risk variants were also associated with subtype-specific disease (P < 0.05), including higher susceptibility for a subtype overrepresented in African American children (TCF3-PBX1) and lower susceptibility for a subtype with excellent prognosis (ETV6-RUNX1). Functional experiments revealed novel B-ALL risk variants had allele-specific differences in transcriptional activity (P < 0.05) in B-cell and leukemia cell lines. These findings shed insights into ancestry-related differences in leukemogenesis and prognosis.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"127 1","pages":"8974"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The latitudinal pattern of fine root intraspecific trait variation among species in plant communities.","authors":"Mengguang Han,Ying Chen,Dayong Gan,Miao Yu,Rui Li,Yunfeng Han,Jiacun Gu,Shuaifeng Li,Jianrong Su,M Luke McCormack,Biao Zhu","doi":"10.1038/s41467-025-64451-6","DOIUrl":"https://doi.org/10.1038/s41467-025-64451-6","url":null,"abstract":"Intraspecific trait variation (ITV) drives plant species performance in natural communities and can have substantial influences on multiple ecological processes. However, current studies on plant belowground (root) ITV are limited in trait coverage, spatial scale and biome type. Here, by conducting in-situ measurements of root traits in three forests from temperate to subtropics and compiling a large-scale dataset of root traits, we explore the latitudinal pattern of root ITV among species within natural plant community, its drivers and implications. Our results show that intraspecific variation constitute a substantial component of the total variation in root traits, and the physiological trait, root exudation, exhibit the highest ITV among traits. The extent of root ITV tends to increase with root diameter across species, with thick-root species having higher root ITV than thin-root species. We also find a significant latitudinal gradient for species' intraspecific root trait variation in natural communities, with increasing ITV towards the equator. These findings can simplify the incorporation of root ITV in trait-based ecology, and contribute to understanding of plant species performance and community assembly under environmental changes.","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"28 1","pages":"9340"},"PeriodicalIF":16.6,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion.","authors":"Giovanni Luchetti,Marin V Miner,Rachael M Peterson,William P Scott,Praveen Krishnamoorthy,Eric M Kofoed,Angel G Jimenez,Hua Zhang,Man Wah Tan,Rohit Reja,Tommy K Cheung,Elizabeth Skippington,Yuxin Liang,Christopher M Rose,Nobuhiko Kayagaki,Kim Newton,Isabella Rauch,Vishva M Dixit","doi":"10.1038/s41586-025-09645-0","DOIUrl":"https://doi.org/10.1038/s41586-025-09645-0","url":null,"abstract":"Diverse pathogen-encoded virulence factors disable apoptosis, pyroptosis or necroptosis, the host cell death programs that remove infected cells1. In the intestine, the extrusion of infected cells into the lumen for elimination provides an additional layer of host defence, but no virulence mechanisms that target the cytoskeletal changes required are known2. Here we show that the Escherichia coli ubiquitin ligase NleL is an inhibitor of intestinal epithelial cell (IEC) extrusion, targeting caspase-4, ROCK1 and ROCK2 for proteasomal degradation. Genetic deletion of Rock1 and Rock2 from cultured IECs diminished inflammasome-induced IEC extrusion. Moreover, mice with Rock1- and Rock2-deficient IECs were less effective than wild-type mice at constraining the numbers of Citrobacter rodentium in the colon. Notably, NleL-deficient C. rodentium triggered more IEC extrusion than did wild-type C. rodentium, resulting in diminished colonization of the colon in infected mice. Our work highlights a host-pathogen arms race focused on dynamic regulation of the host epithelial barrier.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"130 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncertain climate effects of anthropogenic reactive nitrogen.","authors":"Øivind Hodnebrog,Caroline Jouan,Didier A Hauglustaine,Fabien Paulot,Susanne E Bauer,Maureen Beaudor,Michael J Prather,Marit Sandstad,Ragnhild B Skeie,Gunnar Myhre","doi":"10.1038/s41586-025-09337-9","DOIUrl":"https://doi.org/10.1038/s41586-025-09337-9","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"160 1","pages":"E4-E9"},"PeriodicalIF":64.8,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}