综合性期刊最新文献

{"title":"Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling","authors":"Emilie Marhuenda,&nbsp;Ioannis Xanthis,&nbsp;Poppy O. Smith,&nbsp;Aishwarya Prakash,&nbsp;Till Kallem,&nbsp;Pragati Pandey,&nbsp;Darren Graham Samuel Wilson,&nbsp;Amar Azad,&nbsp;Megan Richter,&nbsp;Davor Pavlovic,&nbsp;Katja Gehmlich,&nbsp;Giuseppe Faggian,&nbsp;Pamela Swiatlowska,&nbsp;Elisabeth Ehler,&nbsp;James Levitt,&nbsp;Simon P. Poland,&nbsp;Simon Ameer-Beg,&nbsp;Benjamin T Goult,&nbsp;Thomas Iskratsch","doi":"10.1126/sciadv.adt6083","DOIUrl":"10.1126/sciadv.adt6083","url":null,"abstract":"<div >During heart disease, the cardiac extracellular matrix (ECM) undergoes a structural and mechanical transformation. Cardiomyocytes sense the mechanical properties of their environment, leading to phenotypic remodeling. A critical component of the ECM mechanosensing machinery, including the protein talin, is organized at the cardiomyocyte costamere. Our previous work indicated a different talin tension, depending on the ECM stiffness, but the effects on downstream signaling remained elusive. Here, we identify that the talin interacting proteins DLC1 (deleted in liver cancer 1), RIAM (Rap1-interacting adaptor molecule), and paxillin each preferentially bind to talin at a specific ECM stiffness, this interaction is preserved in the absence of tension, and the interaction is regulated through focal adhesion kinase signaling. Moreover, DLC1 regulates cardiomyocyte RhoA activity in a stiffness-dependent way, whereby the loss of DLC1 results in myofibrillar disarray. Together, this study demonstrates a mechanism of imprinting mechanical information into the talin interactome to fine-tune RhoA activity, with impacts on cardiac health and disease.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adt6083","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic control of electron correlations in photodoped charge-transfer insulators","authors":"Thomas C. Rossi,&nbsp;Nicolas Tancogne-Dejean,&nbsp;Malte Oppermann,&nbsp;Michael Porer,&nbsp;Arnaud Magrez,&nbsp;Rajesh V. Chopdekar,&nbsp;Yayoi Takamura,&nbsp;Urs Staub,&nbsp;Renske M. van der Veen,&nbsp;Angel Rubio,&nbsp;Majed Chergui","doi":"10.1126/sciadv.adx5676","DOIUrl":"10.1126/sciadv.adx5676","url":null,"abstract":"<div >The electronic properties of correlated insulators are governed by the strength of Coulomb interactions, enabling the control of electronic conductivity with external stimuli. This work highlights that the strength of electronic correlations in nickel oxide (NiO), a prototypical charge-transfer insulator, can be coherently reduced by tuning the intensity of an optical pulse excitation. This weakening of correlations persists for hundreds of picoseconds and exhibits a recovery time independent of photodoping density across two orders of magnitude. A broadening of the charge-transfer gap is also observed, consistent with dynamical screening. The high degree of control achieved over both the energy and temporal dynamics of electronic correlations offers a promising avenue to a full optical control of correlated systems and the Mott transition.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx5676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbial production of imidazole propionate drives Parkinson’s pathologies","authors":"Hyunji Park, Jiwon Cheon, Hyojung Kim, Jihye kim, Jihyun Kim, Jeong-Yong Shin, Hyojin Kim, Gaeun Ryu, In Young Chung, Ji Hun Kim, Doeun Kim, Zhidong Zhang, Hao Wu, Katharina R. Beck, Fredrik Bäckhed, Han-Joon Kim, Yunjong Lee, Ara Koh","doi":"10.1038/s41467-025-63473-4","DOIUrl":"https://doi.org/10.1038/s41467-025-63473-4","url":null,"abstract":"<p>Parkinson’s disease (PD) is characterized by the selective degeneration of midbrain dopaminergic neurons and aggregation of α-synuclein. Emerging evidence implicates the gut microbiome in PD, with microbial metabolites proposed as potential pathological mediators. However, the specific microbes and metabolites involved, and whether gut-derived metabolites can reach the brain to directly induce neurodegeneration, remain unclear. Here we show that elevated levels of <i>Streptococcus mutans</i> (<i>S. mutans</i>) and its enzyme urocanate reductase (UrdA), which produces imidazole propionate (ImP), in the gut microbiome of patients with PD, along with increased plasma ImP. Colonization of mice with <i>S. mutans</i> harboring UrdA or <i>Escherichia coli</i> expressing UrdA from <i>S. mutans</i> increases systemic and brain ImP levels, inducing PD-like symptoms including dopaminergic neuronal loss, astrogliosis, microgliosis, and motor impairment. Additionally, <i>S. mutans</i> exacerbates α-synuclein pathology in a mouse model. ImP administration alone recapitulates key PD features, supporting the UrdA–ImP axis as a microbial driver of PD pathology. Mechanistically, mTORC1 activation is crucial for both <i>S. mutans</i>- and ImP-induced PD pathology. Together, these findings identify microbial ImP, produced via UrdA, as a direct pathological mediator of the gut-brain axis in PD.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"62 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covariant spatio-temporal receptive fields for spiking neural networks","authors":"J. E. Pedersen, J. Conradt, T. Lindeberg","doi":"10.1038/s41467-025-63493-0","DOIUrl":"https://doi.org/10.1038/s41467-025-63493-0","url":null,"abstract":"<p>Biological nervous systems constitute important sources of inspiration towards computers that are faster, cheaper, and more energy efficient. Neuromorphic disciplines view the brain as a coevolved system, simultaneously optimizing the hardware and the algorithms running on it. There are clear efficiency gains when bringing the computations into a physical substrate, but we presently lack theories to guide efficient implementations. Here, we present a principled computational model for neuromorphic systems in terms of spatio-temporal receptive fields, based on affine Gaussian kernels over space and leaky-integrator and leaky integrate-and-fire models over time. Our theory is provably covariant to spatial affine and temporal scaling transformations, with close similarities to visual processing in mammalian brains. We use these spatio-temporal receptive fields as a prior in an event-based vision task, and show that this improves the training of spiking networks, which is otherwise known to be problematic for event-based vision. This work combines efforts within scale-space theory and computational neuroscience to identify theoretically well-founded ways to process spatio-temporal signals in neuromorphic systems. Our contributions are immediately relevant for signal processing and event-based vision, and can be extended to other processing tasks over space and time, such as memory and control.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"17 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the regulative development and molecular mechanisms of identical sea urchin twins","authors":"Haruka Suzuki, Junko Yaguchi, Koki Tsuyuzaki, Shunsuke Yaguchi","doi":"10.1038/s41467-025-63111-z","DOIUrl":"https://doi.org/10.1038/s41467-025-63111-z","url":null,"abstract":"<p>Since Hans Driesch’s pioneering work in 1891, it has been known that animal embryos can develop into complete individuals even when divided. However, the developmental processes and molecular mechanisms enabling this self-organization remain poorly understood. In this study, we revisit Driesch’s experiments by examining the development of isolated 2-cell stage blastomeres in the sea urchin, <i>Hemicentrotus pulcherrimus</i>. Contrary to intact embryos, these isolated blastomeres initially form a flat, single layer of dividing cells that eventually round up to be a blastula. Live imaging and knockdown experiments reveal that actomyosin activity at the basal side of the cells and septate junctions drives this process. Intriguingly, we observed temporal disorganization of the anterior-posterior (A-P) and dorsal-ventral (D-V) axes, where the original A-P poles come into contact after sphere shape formation. The disrupted A-P axis is subsequently corrected as the embryos employ the Wnt/β-catenin signaling mechanisms assumed to be used in intact embryos to re-establish a normal axis. These findings suggest that axis re-organization through pre-existing developmental mechanisms is essential for the successful regulative development of divided embryos.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"27 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hope for diabetes: CRISPR-edited cells pump out insulin in a person – and evade immune detection","authors":"","doi":"10.1038/d41586-025-02802-5","DOIUrl":"https://doi.org/10.1038/d41586-025-02802-5","url":null,"abstract":"Edits create cells that don’t trigger an immune response, allowing implant recipient to forego immune-suppressing drugs.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"146 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homo-layer flexible Bi2Te3-based films with high thermoelectric performance","authors":"Dasha Mao,&nbsp;Jianmin Yang,&nbsp;Meng Han,&nbsp;Xiege Huang,&nbsp;Jianrui Wang,&nbsp;Baohai Jia,&nbsp;Zhongbin Wang,&nbsp;Xiao Xu,&nbsp;Lin Xie,&nbsp;Yi Zhou,&nbsp;Guodong Li,&nbsp;Ghim Wei Ho,&nbsp;Jiaqing He","doi":"10.1126/sciadv.adz1019","DOIUrl":"10.1126/sciadv.adz1019","url":null,"abstract":"<div >Here, we demonstrate unconventional scalable and sustainable manufacturing of flexible n-type Bi₂Te₃ films via physical vapor deposition and homo-layer fusion engineering. The achieved ultrahigh power factor of up to 30.0 microwatts per centimeter per square kelvin and ultralow lattice thermal conductivity of 0.38 watts per meter per kelvin at room temperature are attributed to the synergy of modulated modest carrier concentration and weighted mobility in homo-layer films. These results bring forth a maximum output power density of 300 watts per square meter at a temperature gradient of 60 kelvin and a normalized cooling factor of 0.6, which is sufficient to sustain consumer electronics with large-area manufacturing of up to 120 square centimeters. Our developed homo-layer deposition with industry compatibility and scalability potentials highlights a facile yet cost-effective strategy, not only for structure-property relation manipulation in inorganic semiconductors but also for solid-state electronic fabrication for heat harvesting and management frontiers.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 36","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adz1019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nature goes inside the world’s largest ‘mosquito factory’ — here’s the buzz","authors":"","doi":"10.1038/d41586-025-02857-4","DOIUrl":"https://doi.org/10.1038/d41586-025-02857-4","url":null,"abstract":"Hear the biggest stories from the world of science | 05/09/25","PeriodicalId":18787,"journal":{"name":"Nature","volume":"1 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient domain boundary drives ultrafast magnetisation reversal","authors":"Martin Hennecke, Daniel Schick, Themistoklis P. H. Sidiropoulos, Jun-Xiao Lin, Zongxia Guo, Grégory Malinowski, Maximilian Mattern, Lutz Ehrentraut, Martin Schmidbauer, Matthias Schnuerer, Clemens von Korff Schmising, Stéphane Mangin, Michel Hehn, Stefan Eisebitt","doi":"10.1038/s41467-025-63571-3","DOIUrl":"https://doi.org/10.1038/s41467-025-63571-3","url":null,"abstract":"<p>Light-induced magnetisation switching is one of the most intriguing and promising areas where an ultrafast phenomenon can be utilised in technological applications. So far, experiment and theory have considered the origin of all-optical helicity-independent magnetisation switching (AO-HIS) in individual magnetic films only as a microscopically local, thermally-driven process of angular momentum transfer between different subsystems. Here, we demonstrate that this local picture is insufficient and that AO-HIS must also be regarded as a spatially inhomogeneous process along the depth within a few-nanometre thin magnetic layer. Two regions of opposite magnetisation directions are observed, separated by a highly mobile boundary, which propagates along the depth of a 9.4 nm thin Gd₂₅Co₇₅ alloy. The dynamics of this transient boundary determines the final magnetisation state as well as the speed of AO-HIS throughout the entire magnetic layer. The ability to understand the influence of nanoscale and transient inhomogeneities on ultrafast switching phenomena and more generally on phase transitions will open new routes for material design and excitation scenarios in future devices for transferring and storing information.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"34 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addendum: Multipeptide vaccines for melanoma in the adjuvant setting: long-term survival outcomes and post-hoc analysis of a randomized phase II trial","authors":"Emily K. Ninmer, Hong Zhu, Kimberly A. Chianese-Bullock, Margaret von Mehren, Naomi B. Haas, Merrick I. Ross, Lynn T. Dengel, Craig L. Slingluff","doi":"10.1038/s41467-025-63690-x","DOIUrl":"https://doi.org/10.1038/s41467-025-63690-x","url":null,"abstract":"<p>Addendum to: <i>Nature Communications</i> https://doi.org/10.1038/s41467-024-46877-6, published online 22 March 2024</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"23 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}