综合性期刊最新文献

{"title":"Sono-activable and biocatalytic 3D-printed scaffolds for intelligently sequential therapies in osteosarcoma eradication and defect regeneration.","authors":"Xiao Rong, Sutong Xiao, Wei Geng, Bihui Zhu, Ping Mou, Zichuan Ding, Boqing Zhang, Yujiang Fan, Li Qiu, Chong Cheng","doi":"10.1038/s41467-025-61377-x","DOIUrl":"https://doi.org/10.1038/s41467-025-61377-x","url":null,"abstract":"<p><p>To mitigate the necessity for multiple invasive procedures in treating malignant osteosarcoma, an innovative therapeutic approach is imperative to achieve controllable tumor-killing effects and subsequent bone repair. Here, we propose the de novo design of sono-activable and biocatalytic nanoparticles-modified 3D-printed hydroxyapatite (HA) scaffold (HS-ICTO) for intelligently sequential therapies in osteosarcoma eradication and bone defect regeneration. The engineered HS-ICTO scaffold displays superior, spatiotemporally controllable H₂O₂-catalytic performances, which promptly generate massive reactive oxygen species via multienzyme-like mechanisms coupled with sono-activation, thus augmenting tumor cell apoptosis. Furthermore, HS-ICTO can intelligently switch to catalyze H₂O₂ to O₂ within the inflammatory bone defect microenvironment, effectively blocking endogenous H₂O₂-mediated oxidative stress, which positively modulates the osteogenic differentiation of stem cells and ultimately facilitates defect regeneration. We validate that this multifaceted HS-ICTO scaffold possesses robust and on-demand abilities to prevent neoplastic recurrence and promote anti-inflammatory osseous tissue repair, representing a promising platform for precision oncological intervention and regenerative medicine.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"6150"},"PeriodicalIF":14.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small molecule OPA1 inhibitors amplify cytochrome c release and reverse cancer cells resistance to Bcl-2 inhibitors","authors":"Anna Pellattiero,&nbsp;Charlotte Quirin,&nbsp;Federico Magrin,&nbsp;Mattia Sturlese,&nbsp;Alberto Fracasso,&nbsp;Nikolaos Biris,&nbsp;Stéphanie Herkenne,&nbsp;Laura Cendron,&nbsp;Evripidis Gavathiotis,&nbsp;Stefano Moro,&nbsp;Andrea Mattarei,&nbsp;Luca Scorrano","doi":"10.1126/sciadv.adx4562","DOIUrl":"10.1126/sciadv.adx4562","url":null,"abstract":"<div >The guanosine triphosphatase (GTPase) activity of the mitochondrial dynamin-related protein Optic Atrophy 1 (OPA1) regulates cristae remodeling, cytochrome c release, and apoptosis. Elevated OPA1 levels in multiple cancers correlate with reduced therapy sensitivity and poor survival, calling for specific OPA1 GTPase inhibitors. A high-throughput screening of ~10,000 compounds identified MYLS22, a heterocyclic <i>N</i>-pyrazole derivative as a reversible, noncompetitive OPA1 GTPase inhibitor. MYLS22 engaged with OPA1 in vitro and in cells where it induced cristae remodeling and mitochondrial fragmentation contingent on intactness of its predicted OPA1 binding site. MYLS22 enhanced proapoptotic cytochrome c release and sensitized breast adenocarcinoma cells to anti–Bcl-2 therapy, without toxicity on noncancer cells. By MYLS22 structure-activity relationship studies, we obtained Opa1 inhibitor 0 (Opitor-0) that inhibited OPA1, promoted cytochrome c release, and restored anti–Bcl-2 therapy sensitivity more efficiently than MYLS22. These chemical probes validate OPA1 as a therapeutic target to increase cancer cell apoptosis at the mitochondrial level.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx4562","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated in vivo functional screens and multiomics analyses identify α-2,3-sialylation as essential for melanoma maintenance","authors":"Praveen Agrawal,&nbsp;Shuhui Chen,&nbsp;Ana de Pablos,&nbsp;Yellamandayya Vadlamudi,&nbsp;Fatemeh Vand-Rajabpour,&nbsp;Faezeh Jame-Chenarboo,&nbsp;Swarnali Kar,&nbsp;Amanda Flores Yanke,&nbsp;Pietro Berico,&nbsp;Eleazar Miera Saenz de Vega,&nbsp;Farbod Darvishian,&nbsp;Iman Osman,&nbsp;Amaia Lujambio,&nbsp;Lara K. Mahal,&nbsp;Eva Hernando","doi":"10.1126/sciadv.adg3481","DOIUrl":"10.1126/sciadv.adg3481","url":null,"abstract":"<div >Aberrant glycosylation is a hallmark of cancer biology, and altered glycosylation influences multiple facets of melanoma progression. To identify glycosyltransferases, glycans, and glycoproteins essential for melanoma maintenance, we conducted an in vivo growth screen with a pooled short hairpin RNA library of glycosyltransferases, lectin microarray profiling of benign nevus and melanoma samples, and mass spectrometry–based glycoproteomics. We found that α-2,3-sialyltransferases ST3GAL1 and ST3GAL2 and corresponding α-2,3–linked sialosides are up-regulated in melanoma compared to nevi and are essential for melanoma growth. Glycoproteomics revealed that glycoprotein targets of ST3GAL1 and ST3GAL2 are enriched in transmembrane proteins involved in growth signaling, including the amino acid transporter SLC3A2/CD98hc. CD98hc suppression mimicked the effect of ST3GAL1 and ST3GAL2 silencing, inhibiting melanoma cell proliferation. We found that both CD98hc protein stability and its prosurvival effect on melanoma are dependent upon α-2,3-sialylation mediated by ST3GAL1 and ST3GAL2. Our studies reveal α-2,3-sialosides functionally contributing to melanoma maintenance, supporting ST3GAL1 and ST3GAL2 as therapeutic targets in melanoma.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adg3481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of terahertz-frequency orbitally coupled magnons in a kagome ferromagnet","authors":"Mengqian Che,&nbsp;Weizhao Chen,&nbsp;Maoyuan Wang,&nbsp;F. Michael Bartram,&nbsp;Liangyang Liu,&nbsp;Xuebin Dong,&nbsp;Jinjin Liu,&nbsp;Yidian Li,&nbsp;Hao Lin,&nbsp;Zhiwei Wang,&nbsp;Enke Liu,&nbsp;Yugui Yao,&nbsp;Zhe Yuan,&nbsp;Guang-Ming Zhang,&nbsp;Luyi Yang","doi":"10.1126/sciadv.adw1182","DOIUrl":"10.1126/sciadv.adw1182","url":null,"abstract":"<div >In ferromagnetic materials, magnons—quanta of spin waves—typically resonate in the gigahertz range. Beyond conventional magnons, while theoretical studies have predicted magnons associated with orbital magnetic moments, their direct observation has remained challenging. Here, we present the discovery of two distinct terahertz orbitally coupled magnon resonances in the topological kagome ferromagnet Co₃Sn₂S₂. Using time-resolved Kerr rotation spectroscopy, we pinpoint two magnon resonances at 0.61 and 0.49 terahertz at 6 kelvin, surpassing all previously reported magnon resonances in ferromagnets due to strong magnetocrystalline anisotropy. These dual modes originate from the strong coupling of localized spin and orbital magnetic moments. These findings unveil an unconventional category of magnons in a ferromagnet stemming from orbital magnetic moments and position Co₃Sn₂S₂ as a promising candidate for high-speed terahertz spintronic applications.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw1182","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal sea ice characterized the glacial Arctic-Atlantic gateway over the past 750,000 years","authors":"Jochen Knies,&nbsp;Lukas Smik,&nbsp;Pengyang Song,&nbsp;Monica Winsborrow,&nbsp;Henning A. Bauch,&nbsp;Gerrit Lohmann,&nbsp;Simon T. Belt","doi":"10.1126/sciadv.adu7681","DOIUrl":"10.1126/sciadv.adu7681","url":null,"abstract":"<div >The past occurrence of an extreme ~1-kilometer–thick Arctic Ocean–Nordic Seas ice shelf has been inferred from submarine landscape features and geochemical records, although fundamental aspects of its characteristics, impacts, and timing remain highly debated. Here, we challenge this pan-Arctic glaciation hypothesis by investigating two sites from the Arctic-Atlantic gateway (AAG) and the Nordic Seas. Suborbital to millennial-scale surface water bioproductivity changes provide no evidence for a continuous ice shelf in the AAG and the Nordic Seas over the past ~750,000 years. Instead, proxy data and model simulations reveal the persistent presence of seasonal sea ice cover and open water phytoplankton blooms during both glacial and interglacial times. If the AAG and Nordic Seas were ever covered by an ice shelf during these times, then it must have been a partial, or at best, a very short-lived glacial phenomenon.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu7681","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unleashing the potential of lignin with innovative trifunctional binary deep eutectic solvent strategy: Isolation of uncondensed lignin","authors":"Haichao Li,&nbsp;Deqiang Li,&nbsp;Yuan He,&nbsp;Chaobing Luo,&nbsp;Wu Lan,&nbsp;Arthur J. Ragauskas,&nbsp;Tingting You,&nbsp;Feng Xu","doi":"10.1126/sciadv.adv7299","DOIUrl":"10.1126/sciadv.adv7299","url":null,"abstract":"<div >Highly efficient conversion of lignin into value-added chemicals and materials is trapped in the inevitable cleavage of β-O-4 linkages and formation of highly condensed structures with deep colors during lignin isolation. Here, we develop a trifunctional choline chloride/glyoxylic acid (ChCl/GA) binary deep eutectic solvent with a π-π conjugate structure and moderate acidity for the fast isolation of light-colored lignin with near proto-structures (exceeding 88% of delignification ratio for 1 hour). The synergetic interaction of GA and ChCl substantially reduced Gibbs free energy of acetal reaction and thoroughly captured reactive intermediates, precisely activating the following key functions: stabilizing β-O-4 linkages, inhibiting condensation reaction, and shielding –OH groups. These enabled efficient isolation of uncondensed, abundant β-O-4 linkage (45.80/100 C9; 79% retention) and light-colored lignin. A near-theoretical yield of aromatic monomers upon depolymerization and high performances as adhesives for lignocellulosic bioplastics were achieved. This work unleashes the valorization potential of lignin by a relatively green and fast strategy for sustainable biorefineries.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv7299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Origin of immunoglobulins and T cell receptors: A candidate gene for invasion by the RAG transposon","authors":"Martin F. Flajnik,&nbsp;Robyn L. Stanfield,&nbsp;Ana Verissimo,&nbsp;Harold R. Neely,&nbsp;Antonio Muñoz-Mérida,&nbsp;Michael F. Criscitiello,&nbsp;Ian A. Wilson,&nbsp;Yuko Ohta","doi":"10.1126/sciadv.adw1273","DOIUrl":"10.1126/sciadv.adw1273","url":null,"abstract":"<div >Rearranging antigen receptors (AgRs) arose when a variable (V) domain exon was invaded by the recombination-activating gene (RAG) transposon ~500 million years ago. We show here that the elasmobranch immunoglobulin heavy (IgH) isotypes—IgM, IgW, and IgNAR—are linked near the αδ T cell receptor (TCRαδ) locus. This linkage presages the emergence of the osteichthyan IgH translocon arrangement and clarifies the relationship between IgH and TCRδs. Recently, we reported <i>UrIg</i>, a nonrearranging, elasmobranch major histocompatibility complex (MHC)-linked AgR gene. Here, we describe a nonrearranging <i>UrIg</i> paralogue, <i>UrIg2</i>, linked to this IgM/IgNAR/IgW/TCRαδ gene cluster in an AgR complex (AgRC). UrIg2 amino-terminal domains make homodimers where the C2-C3 structure resembles IgGFc. A relative of the UrIg2 V domain exon was invaded by the RAG transposon, revealing the genesis of the adaptive immune system. Our data indicate that an ancestral chromosome encoded an AgR precursor, undergoing RAG-mediated rearrangement after genome-wide duplication on one chromosome and retaining nonrearranging relics in the MHC and AgRC.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw1273","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer","authors":"Laura Urbach,&nbsp;Lena Wieland,&nbsp;Frederike Penz,&nbsp;Rebecca Diya Samuel,&nbsp;Stefan Küffer,&nbsp;Lukas Klein,&nbsp;Christof Lenz,&nbsp;Ulrich Sax,&nbsp;Michael Ghadimi,&nbsp;Ramona Schulz-Heddergott,&nbsp;Elisabeth Hessmann,&nbsp;Volker Ellenrieder,&nbsp;Nelson Dusetti,&nbsp;Shiv K. Singh","doi":"10.1126/sciadv.adu2339","DOIUrl":"10.1126/sciadv.adu2339","url":null,"abstract":"<div >In ~70% of patients with pancreatic ductal adenocarcinoma, the <i>TP53</i> gene acquires gain-of-function (GOF) mutations leading to rapid disease progression. Specifically, missense p53 (misp53) GOF mutations associate with therapy resistance and worse clinical outcomes. However, the molecular functions of distinct misp53 mutants in plasticity and therapy response remain unclear. Integrating multicenter patient data and multi-omics, we report that the misp53^R273H/C mutant is associated with cell cycle progression and a basal-like state compared to the misp53^R248W/Q mutant. Loss of misp53^R273H/C decreased tumor growth and liver metastasis while prolonging survival in preclinical models. We found that misp53^R273H/C specifically regulated the Rb/DREAM axis involved in cell cycle regulation. Notably, a clinical CDK4/6 inhibitor reduced misp53^R273H/C mutant expression. However, it triggered MAPK/ERK-mediated resistance mechanisms, enhancing cell survival and resistance to CDK4/6 inhibitors. Combining MAPK/ERK and CDK4/6 inhibitors reduced misp53^R273H/C-associated oncogenic functions. Thus, distinct misp53 mutants show unique cell-intrinsic plasticity, therapeutic vulnerabilities, and resistance mechanisms.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adu2339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonliving dehydrated leaves-inspired surface anti-wrinkling","authors":"Xin-Lu Deng,&nbsp;Kai-Ming Hu,&nbsp;Wen-Qiang Yuan,&nbsp;Zhi-Qi Dong,&nbsp;Heng Zou,&nbsp;Fan Yang,&nbsp;Xue-Song Jiang,&nbsp;Guang Meng,&nbsp;Wen-Ming Zhang","doi":"10.1126/sciadv.adx7398","DOIUrl":"10.1126/sciadv.adx7398","url":null,"abstract":"<div >“Living” organisms in nature exhibit robust and biologically intelligent surface anti-wrinkling. Nonetheless, the complexities of self-regulating stress or structural characteristics through growth or gene expression render the anti-wrinkling of “nonliving” artificial surfaces using bionic principles a pressing yet formidable challenge. Here, inspired by nonliving dehydrated leaves, we propose an on-demand customizable, material invariant, parametric surface anti-wrinkling strategy using leaf vein–imitated boundary curvature–coupled constraints. This strategy allows for an exact surface customization with enhanced anti-wrinkling capability, tailored to specific anti-wrinkling demands while maintaining the original cross-section materials. The defined parameters, anti-wrinkling width and concave radius, are customized by the anti-wrinkling design criteria via the dimensionless dual-correction stiffness model, which are simple linear or quadratic functions of anti-wrinkling demands and cross-section properties. Experiments at different scales and materials validate the correctness of the design criteria. The strategy in this study is effective on diverse wrinkle-prone surfaces at multiple scales and can inform real engineering design of the nonliving artificial surfaces.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx7398","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteria.","authors":"Belen Sotomayor, Thomas C Donahue, Sai Pooja Mahajan, May N Taw, Sophia W Hulbert, Erik J Bidstrup, D Natasha Owitipana, Alexandra Pang, Xu Yang, Souvik Ghosal, Christopher A Alabi, Parastoo Azadi, Jeffrey J Gray, Michael C Jewett, Lai-Xi Wang, Matthew P DeLisa","doi":"10.1038/s41467-025-61440-7","DOIUrl":"https://doi.org/10.1038/s41467-025-61440-7","url":null,"abstract":"<p><p>Human immunoglobulin G (IgG) antibodies are a major class of biotherapeutics and undergo N-linked glycosylation in their Fc domain, which is critical for immune functions and therapeutic activity. Hence, technologies for producing authentically glycosylated IgGs are in high demand. Previous attempts to engineer Escherichia coli for this purpose have met limited success due in part to the lack of oligosaccharyltransferase (OST) enzymes that can install N-glycans at the conserved N297 site in the Fc region. Here, we identify a single-subunit OST from Desulfovibrio marinus with relaxed substrate specificity that catalyzes glycosylation of native Fc acceptor sites. By chemoenzymatic remodeling the attached bacterial glycans to homogeneous, asialo complex-type G2 N-glycans, the E. coli-derived Fc binds human FcγRIIIa/CD16a, a key receptor for antibody-dependent cellular cytotoxicity (ADCC). Overall, the discovery of D. marinus OST provides previously unavailable biocatalytic capabilities and sets the stage for using E. coli to produce fully human antibodies.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"6152"},"PeriodicalIF":14.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}