NaturePub Date : 2025-08-06DOI: 10.1038/s41586-025-09463-4
Michelle B. Chen, Xian Jiang, Stephen R. Quake, Thomas C. Südhof
{"title":"Author Correction: Persistent transcriptional programmes are associated with remote memory","authors":"Michelle B. Chen, Xian Jiang, Stephen R. Quake, Thomas C. Südhof","doi":"10.1038/s41586-025-09463-4","DOIUrl":"https://doi.org/10.1038/s41586-025-09463-4","url":null,"abstract":"<p>Correction to: <i>Nature</i> https://doi.org/10.1038/s41586-020-2905-5 Published online 11 November 2020</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"31 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vishal Yeddu, Khulud Almasabi, Yafeng Xu, Augusto Amaro, Shuang Qiu, Sergey Dayneko, Dongyang Zhang, Parinaz Moazzezi, Christopher Tremblay, Muhammad Naufal Lintangpradipto, Heather L. Buckley, Omar F. Mohammed, Osman M. Bakr, Makhsud I. Saidaminov
{"title":"In-situ self-assembly of hole transport monolayer during crystallization for efficient single-crystal perovskite solar cells","authors":"Vishal Yeddu, Khulud Almasabi, Yafeng Xu, Augusto Amaro, Shuang Qiu, Sergey Dayneko, Dongyang Zhang, Parinaz Moazzezi, Christopher Tremblay, Muhammad Naufal Lintangpradipto, Heather L. Buckley, Omar F. Mohammed, Osman M. Bakr, Makhsud I. Saidaminov","doi":"10.1038/s41467-025-62393-7","DOIUrl":"https://doi.org/10.1038/s41467-025-62393-7","url":null,"abstract":"<p>Single-crystal perovskite solar cells (SC-PSCs) are emerging as a promising technology owing to their intrinsically low defect densities, long carrier diffusion lengths, and enhanced stability compared to their polycrystalline counterpart. However, their performance has been limited by interface-related losses, particularly at the perovskite/charge transport layer, which hinders effective hole extraction and promotes non-radiative recombination. In this work, we introduce a self-assembled monolayer (SAM) deposition strategy that exploits an asymmetric substrate stack configuration during space-confined inverse temperature crystallization (SC-ITC). This configuration triggers an in-situ migration of SAM molecules from the SAM-coated substrate to the uncoated substrate, resulting in a denser and more homogeneous SAM coating than the conventional spin-coating method can achieve. The improved SAM coverage significantly enhances hole extraction. Consequently, our SC-PSCs achieved power conversion efficiency as high as 24.32%.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"157 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-08-06DOI: 10.1126/sciadv.adw6867
Runchuan Yan, Yan Zhang, Jingjing Zhang, Xiangyi Zhang, Yue Han, Mengfei Wang, Dan Wang, Shengnan Huang, Wei Liu, Qi Shi, Xiaoping Dong, Wen-Quan Zou, Zhen Li, Jiyan Ma
{"title":"Soluble N-terminal region of prion protein causes rapid neurodegeneration in prion disease","authors":"Runchuan Yan, Yan Zhang, Jingjing Zhang, Xiangyi Zhang, Yue Han, Mengfei Wang, Dan Wang, Shengnan Huang, Wei Liu, Qi Shi, Xiaoping Dong, Wen-Quan Zou, Zhen Li, Jiyan Ma","doi":"10.1126/sciadv.adw6867","DOIUrl":"https://doi.org/10.1126/sciadv.adw6867","url":null,"abstract":"Rapid neurodegeneration distinguishes prion disease from other neurodegenerative disorders. Notably, normal prion protein (PrP <jats:sup>C</jats:sup> ) is essential for prion-induced rapid neurodegeneration, but the underlying mechanism remains unknown. Here, we show that the unstructured N-terminal region of PrP <jats:sup>C</jats:sup> induces rapid and lethal neurodegeneration in mice, accompanied by the hallmark of prion disease, spongiosis. The neurotoxic N-terminal PrP is soluble, associates peripherally with lipid membranes, and induces neurotoxicity only when a critical threshold is exceeded. Both the N-terminally localized KKRPKP sequence and octarepeats contribute to neurotoxicity, with KKRPKP being essential. Without it, the N-terminal PrP is innocuous but exacerbates either neurodegeneration caused by N-terminal PrP or neurodegeneration in prion disease induced by intracerebral prion inoculation in mice. Our findings establish that soluble N-terminal PrP causes rapid neurodegeneration in prion disease and is a target for intervention.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"162 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-08-06DOI: 10.1126/sciadv.adt2041
Gavin D. Madakumbura, Max A. Moritz, Karen A. McKinnon, A. Park Williams, Stefan Rahimi, Benjamin Bass, Jesse Norris, Rong Fu, Alex Hall
{"title":"Anthropogenic warming drives earlier wildfire season onset in California","authors":"Gavin D. Madakumbura, Max A. Moritz, Karen A. McKinnon, A. Park Williams, Stefan Rahimi, Benjamin Bass, Jesse Norris, Rong Fu, Alex Hall","doi":"10.1126/sciadv.adt2041","DOIUrl":"https://doi.org/10.1126/sciadv.adt2041","url":null,"abstract":"Annual wildfire area in California has rapidly grown in recent decades, with increasingly negative impacts on people. The fire season is also lengthening, with an earlier onset. This trend has been hypothesized to be driven by anthropogenic warming, but it has yet to be quantitatively attributed to climate drivers. Using a comprehensive fire occurrence dataset, we analyze fire season onset and climate controls on its variability and change during 1992–2020 in 13 California ecoregions. Northern California ecoregions show stronger trends toward earlier onset compared to more arid southern California ecoregions. Onset has trended earlier for all but one ecoregion. Interannual variability of onset is dominated by climate variability and its influence on fuel moisture. Trend attribution inferred from onset-climate relationships suggests that anthropogenic warming advanced fire season onset by 6 to 46 days during 1992–2020 in 11 of 13 ecoregions. Continued warming is expected to further promote earlier fire season onsets.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"19 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Science AdvancesPub Date : 2025-08-06DOI: 10.1126/sciadv.adw4954
Barbara Arbeithuber, Kate Anthony, Bonnie Higgins, Peter Oppelt, Omar Shebl, Irene Tiemann-Boege, Francesca Chiaromonte, Thomas Ebner, Kateryna D. Makova
{"title":"Allele frequency selection and no age-related increase in human oocyte mitochondrial mutations","authors":"Barbara Arbeithuber, Kate Anthony, Bonnie Higgins, Peter Oppelt, Omar Shebl, Irene Tiemann-Boege, Francesca Chiaromonte, Thomas Ebner, Kateryna D. Makova","doi":"10.1126/sciadv.adw4954","DOIUrl":"https://doi.org/10.1126/sciadv.adw4954","url":null,"abstract":"Mitochondria, cellular powerhouses, harbor DNA [mitochondrial DNA (mtDNA)] inherited from the mothers. mtDNA mutations can cause diseases, yet whether they increase with age in human oocytes remains understudied. Here, using highly accurate duplex sequencing, we detected de novo mutations in single oocytes, blood, and saliva in women 20 to 42 years of age. We found that, with age, mutations increased in blood and saliva but not in oocytes. In oocytes, mutations with high allele frequencies were less prevalent in coding than noncoding regions, whereas mutations with low allele frequencies were more uniformly distributed along the mtDNA, suggesting frequency-dependent purifying selection. Thus, mtDNA in human oocytes is protected against accumulation of mutations with aging and having functional consequences. These findings are particularly timely as humans tend to reproduce later in life.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"27 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lead isotopic evidence for an old and rapid lunar magma ocean","authors":"Ya-Wen Zhang, Si-Zhang Sheng, Shui-Jiong Wang, Qiu-Li Li, Jun-Xiang Hua, Shijie Li, Xian-Hua Li","doi":"10.1126/sciadv.adu5111","DOIUrl":"https://doi.org/10.1126/sciadv.adu5111","url":null,"abstract":"The Moon’s early history remains enigmatic, with intensive debate over the timing and duration of the lunar magma ocean (LMO) and its consequences on the early thermal and chemical evolution of the Moon. Here, we report a lead-lead isochron age of 4406.1 ± 3.2 million years ago (Ma) with an extraordinarily high initial lead (Pb) composition (HIP) for a lunar meteorite Northwest Africa 14729. The HIP at ~4406 Ma implies Pb isotopic evolution from an early-formed, high-μ ( <jats:sup>238</jats:sup> U/ <jats:sup>204</jats:sup> Pb > 5000) reservoir that is genetically linked to the last remaining liquid of the LMO called urKREEP. This requires that lunar primordial differentiation was completed within approximately 150 million years (Myr) after the Solar System’s formation.","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"16 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leire Retegui-Schiettekatte, Maike Schumacher, Fan Yang, Henrik Madsen, Ehsan Forootan
{"title":"An ensemble Kalman filter with rescaling disaggregation for assimilating terrestrial water storage into hydrological models.","authors":"Leire Retegui-Schiettekatte, Maike Schumacher, Fan Yang, Henrik Madsen, Ehsan Forootan","doi":"10.1038/s41598-025-13602-2","DOIUrl":"https://doi.org/10.1038/s41598-025-13602-2","url":null,"abstract":"<p><p>Assimilating satellite-based Terrestrial Water Storage (TWS) observations can improve the vertical summation of water storage states in hydrological models. However, it can degrade individual storage compartments or hydrological fluxes, limiting the applicability of TWS Data Assimilation (DA) for water management and flood monitoring. This issue arises from the ensemble-based TWS update disaggregation approach used by DA techniques like the Ensemble Kalman Filter (EnKF). Thus, this study makes two key contributions. First, we introduce a novel analysis method that provides quantitative and qualitative insights into how individual storage compartments are affected during TWS DA, by examining the sign and magnitude of the individual storage updates and their responses. Second, we propose a new disaggregation approach, EnKF-R, which \"rescales\" the individual storage of model compartments to match the updated TWS, avoiding the use of ensemble statistics within the disaggregation process. The EnKF-R approach was tested in two climatologically different river basins and validated against both synthetic and real independent data. Our results show that EnKF-R produces similar TWS estimates to the classical EnKF while reducing degradations in individual water storage compartments and with lower computational cost, making it a promising alternative. Limitations regarding spatial continuity and uncertainty estimation require further developments.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"28675"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical characteristics of thyroid eye disease and expression profile of peripheral blood immune cells.","authors":"Hongli Lin, Honghong Duan, Jingyi Zheng, Zhengrong Jiang, Yajing Xu, Huibin Huang","doi":"10.1038/s41598-025-08904-4","DOIUrl":"https://doi.org/10.1038/s41598-025-08904-4","url":null,"abstract":"<p><p>This study included patients with thyroid eye disease (n = 81) and Graves' disease (n = 165) for a cross-sectional study. Then, peripheral blood mononuclear cells (PBMCs) were collected from patients with thyroid eye disease (n = 5), Graves' disease (n = 15), and normal individuals (n = 5) for RNA-seq. WGCNA analysis was conducted on the RNA-seq results to identify genes related to thyroid eye disease, and these genes were verified by RT-qPCR. The results suggest that: (1) Neutrophil counts were elevated in the TED group compared to the GD group. (2) Ten hub genes, MMP9, BPI, CD177, MPO, CEACAM8, CEACAM1, SLPI, AZU1, KCNJ15 and TNFRSF10C, were identified. The above hub genes were positively correlated with neutrophils.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"28666"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tathagat Banerjee, Prachi Chhabra, Manoj Kumar, Abhay Kumar, Kumar Abhishek, Mohd Asif Shah
{"title":"Pyramidal attention-based T network for brain tumor classification: a comprehensive analysis of transfer learning approaches for clinically reliable and reliable AI hybrid approaches.","authors":"Tathagat Banerjee, Prachi Chhabra, Manoj Kumar, Abhay Kumar, Kumar Abhishek, Mohd Asif Shah","doi":"10.1038/s41598-025-11574-x","DOIUrl":"https://doi.org/10.1038/s41598-025-11574-x","url":null,"abstract":"<p><p>Brain tumors are a significant challenge to human health as they impair the proper functioning of the brain and the general quality of life, thus requiring clinical intervention through early and accurate diagnosis. Although current state-of-the-art deep learning methods have achieved remarkable progress, there is still a gap in the representation learning of tumor-specific spatial characteristics and the robustness of the classification model on heterogeneous data. In this paper, we introduce a novel Pyramidal Attention-Based bi-partitioned T Network (PABT-Net) that combines the hierarchical pyramidal attention mechanism and T-block based bi-partitioned feature extraction, and a self-convolutional dilated neural classifier as the final task. Such an architecture increases the discriminability of the space and decreases the false forecasting by adaptively focusing on informative areas in brain MRI images. The model was thoroughly tested on three benchmark datasets, Figshare Brain Tumor Dataset, Sartaj Brain MRI Dataset, and Br35H Brain Tumor Dataset, containing 7023 images labeled in four tumor classes: glioma, meningioma, no tumor, and pituitary tumor. It attained an overall classification accuracy of 99.12%, a mean cross-validation accuracy of 98.77%, a Jaccard similarity index of 0.986, and a Cohen's Kappa value of 0.987, indicating superb generalization and clinical stability. The model's effectiveness is also confirmed by tumor-wise classification accuracies: 96.75%, 98.46%, and 99.57% in glioma, meningioma, and pituitary tumors, respectively. Comparative experiments with the state-of-the-art models, including VGG19, MobileNet, and NASNet, were carried out, and ablation studies proved the effectiveness of NASNet incorporation. To capture more prominent spatial-temporal patterns, we investigated hybrid networks, including NASNet with ANN, CNN, LSTM, and CNN-LSTM variants. The framework implements a strict nine-fold cross-validation procedure. It integrates a broad range of measures in its evaluation, including precision, recall, specificity, F1-score, AUC, confusion matrices, and the ROC analysis, consistent across distributions. In general, the PABT-Net model has high potential to be a clinically deployable, interpretable, state-of-the-art automated brain tumor classification model.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"28669"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144790019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}