PLoS ONE最新文献

{"title":"Expression of Concern: Electromyographic activity of pelvic floor muscles in different positions during the use an innovative vaginal educator: Cross-sectional study.","authors":"","doi":"10.1371/journal.pone.0360775","DOIUrl":"https://doi.org/10.1371/journal.pone.0360775","url":null,"abstract":"","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"21 10","pages":"e0360775"},"PeriodicalIF":2.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern: Spatial pattern of China's rural digital economy based on subjective-Objective evaluation: Evidence from 2085 counties.","authors":"","doi":"10.1371/journal.pone.0360864","DOIUrl":"https://doi.org/10.1371/journal.pone.0360864","url":null,"abstract":"","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"21 10","pages":"e0360864"},"PeriodicalIF":2.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern: Decision analysis of PPP project's parties based on deep consumer participation.","authors":"","doi":"10.1371/journal.pone.0360779","DOIUrl":"https://doi.org/10.1371/journal.pone.0360779","url":null,"abstract":"","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"21 10","pages":"e0360779"},"PeriodicalIF":2.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Pyrroloquinoline Quinine Inhibits RANKL-Mediated Expression of NFATc1 in Part via Suppression of c-Fos in Mouse Bone Marrow Cells and Inhibits Wear Particle-Induced Osteolysis in Mice.","authors":"","doi":"10.1371/journal.pone.0360868","DOIUrl":"https://doi.org/10.1371/journal.pone.0360868","url":null,"abstract":"","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"21 10","pages":"e0360868"},"PeriodicalIF":2.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern: Evaluation of China's provincial digital economy development level and its coupling coordination relationship.","authors":"","doi":"10.1371/journal.pone.0360865","DOIUrl":"https://doi.org/10.1371/journal.pone.0360865","url":null,"abstract":"","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"21 10","pages":"e0360865"},"PeriodicalIF":2.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Reduced SOD2 expression does not influence prion disease course or pathology in mice.","authors":"Simote T Foliaki, Brent Race, Katie Williams, Chase Baune, Bradley R Groveman, Cathryn L Haigh","doi":"10.1371/journal.pone.0360777","DOIUrl":"https://doi.org/10.1371/journal.pone.0360777","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0259597.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"21 10","pages":"e0360777"},"PeriodicalIF":2.8,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149224718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of SGK1 as a candidate regulator associated with myeloid cell senescence in ME/CFS: An integrative transcriptomic and experimental study.","authors":"Yan Jin, Rui Qin, Wan Li, Jin Liu, Xinghua Chen","doi":"10.1371/journal.pone.0359082","DOIUrl":"https://doi.org/10.1371/journal.pone.0359082","url":null,"abstract":"<p><strong>Background: </strong>Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex illness lacking objective diagnostic biomarkers and clear pathophysiological understanding. Patients exhibit immune dysregulation and chronic inflammation reminiscent of aging phenotypes, yet the role of myeloid cell senescence in this disease remains unexplored.</p><p><strong>Methods: </strong>A stepwise integrative transcriptomic and computational strategy was employed. Differentially expressed genes were identified from the bulk transcriptomic dataset GSE14577. Weighted gene co-expression network analysis was performed to identify key modules correlated with the ME/CFS phenotype. Candidate genes were obtained by intersecting these modules with aging-related genes from the GenAge database. Core hub genes were further selected using LASSO regression and random forest machine learning algorithms. Cell type-specific expression was mapped using single-cell RNA sequencing data GSE214283, and functional validation was conducted via siRNA knockdown in a THP-1 cell senescence model.</p><p><strong>Results: </strong>Integrative analysis identified HMGCR and SGK1 as core hub genes. Functional enrichment analysis revealed that candidate genes were enriched in pathways related to cellular senescence and inflammation. Single-cell transcriptomics analysis suggested that SGK1 expression was enriched in myeloid cell populations, including monocytes and neutrophils, in individuals with ME/CFS, whereas HMGCR showed a broader expression pattern. Single-gene GSEA indicated that SGK1 was associated with autophagy and lysosomal function. In vitro experiments showed that SGK1 expression was significantly upregulated in D-galactose-induced senescent THP-1 cells, and SGK1 knockdown markedly reduced the mRNA expression levels of senescence markers p16, p21, and p53.</p><p><strong>Conclusion: </strong>This study identifies SGK1 as a candidate molecule associated with myeloid cell senescence-related alterations in ME/CFS. Integrated transcriptomic, single-cell, and experimental analyses suggest a potential link between SGK1 expression and aging-associated immune alterations. However, further validation in primary ME/CFS-derived immune cells and clinical cohorts is required to determine the biological significance and clinical relevance of SGK1.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"21 10","pages":"e0359082"},"PeriodicalIF":2.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent TMS-EEG to characterise interhemispheric signal propagation over the motor and prefrontal regions: An independent replication of GABAB receptor mechanisms.","authors":"Jie Zhou, Yiting He, Chenxia Jin, Chen Yang, Yazhen Han, Yujun Wang, Zhen Zhen, Zhimin Huang, Shuyan Shi, Xianwei Che, Jiqing He","doi":"10.1371/journal.pone.0360250","DOIUrl":"https://doi.org/10.1371/journal.pone.0360250","url":null,"abstract":"<p><p>Callosal abnormalities disrupt interhemispheric communications that impair the recovery of a series of neurological and psychiatric disorders. Understanding interhemispheric communication could help identify treatments for disorders with dysfunctional callosal transmission. This study aimed to validate the sensitivity of a TMS-EEG-based measure of interhemispheric signal propagation (ISP) to GABAB receptor modulation, while independently replicating the pharmacological mechanisms of interhemispheric inhibition. A group of 29 participants received an oral dose of either baclofen, a GABAB receptor agonist, or a placebo. Before and after drug intake, single-pulse TMS-EEG was applied to assess ISP in both the motor and prefrontal regions. Our findings indicated that baclofen increased interhemispheric inhibition over the motor region, indexed by significantly decreased ISP (p = 0.037). No significant effect was observed in the dorsolateral prefrontal region (p = 0.186), suggesting regional specificity in GABAB receptor modulation of ISP. These findings uncovered the pharmacological mechanisms of interhemispheric inhibition as indexed by ISP. They also highlight the potential of ISP for characterising interhemispheric communication, which could inform the treatment for a series of disorders with dysfunctional callosal transmission.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"21 10","pages":"e0360250"},"PeriodicalIF":2.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta reinforcement learning for robust quadruped locomotion under joint failures.","authors":"Likai Wu, Chee-Onn Chow, Wei Ru Wong, Joon Huang Chuah, Jeevan Kanesan, Meina Zhang","doi":"10.1371/journal.pone.0361099","DOIUrl":"https://doi.org/10.1371/journal.pone.0361099","url":null,"abstract":"<p><p>Joint failures can disrupt gait coordination, velocity tracking, and body stability in quadruped robots by reducing the available control authority. This study investigates faults in which joints remain locked at fixed angles and presents Adjudicate Reconfiguration and Evolving Regularization Meta Reinforcement Learning (ARER-MetaRL). The framework combines task inference from context, modular routing tailored to each task through an Adjudicate Reconfiguration (AR) network, and Evolving Gradient Regularization (ER) to support rapid adaptation. Tasks differ in the identities and locking angles of the faulty joints, the number of simultaneous faults, the commanded motion direction, and the terrain. Experiments in NVIDIA Isaac Sim cover all 12 actuated joints, with 0-3 stuck joints during meta-training and severity tests involving up to 6 simultaneously stuck joints. ARER-MetaRL achieves higher Mean Episode Linear Velocity Tracking Reward (MELV) and Mean Episode Roll-Pitch Tracking Reward (MERP) than single-task reinforcement learning, ablated variants, and the evaluated learning and adaptation baselines. Cumulative rewards further demonstrate the benefit of combining the proposed components. In the study of fault severity, ARER-MetaRL achieves MELV/MERP values of 0.86/0.84 with one stuck joint and 0.55/0.54 with six stuck joints, compared with 0.21/0.18 and 0.05/0.03, respectively, for the single-task baseline. These results show improved adaptation across different configurations of locked joints and terrain conditions.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"21 10","pages":"e0361099"},"PeriodicalIF":2.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived AIGC saturation and AI content fatigue on short-video platforms: An appraisal-based structural equation modeling study.","authors":"Zedai Wang, Chao Tang","doi":"10.1371/journal.pone.0360731","DOIUrl":"https://doi.org/10.1371/journal.pone.0360731","url":null,"abstract":"<p><p>Artificial intelligence-generated content (AIGC) is increasingly embedded in short-video platforms, where algorithmic recommendation systems expose users to high volumes of rapidly produced synthetic media. Although prior research has examined generative AI from the perspectives of creativity, productivity, and technology adoption, less is known about how ordinary users evaluate repeated exposure to AI-generated short videos. This study develops and tests an appraisal-based model of AI content fatigue, distinguishing perceived AIGC saturation from users' appraisals of low-quality prevalence, narrative homogenization, and content overload. A cross-sectional online survey was conducted among Chinese short-video users in May 2026. After excluding invalid responses, 513 valid questionnaires were analyzed using confirmatory factor analysis and structural equation modeling. The adjusted structural model showed acceptable fit to the data, χ²(1321) = 1991.541, χ²/df = 1.508, CFI = .946, TLI = .929, IFI = .947, and RMSEA = .031. Perceived AIGC saturation was positively associated with perceived low-quality prevalence, perceived narrative homogenization, and perceived content overload. Perceived low-quality prevalence had the largest estimated coefficient, followed by perceived content overload, whereas perceived narrative homogenization was not supported under bootstrap inference. AI content fatigue was negatively associated with satisfaction and continued viewing intention. Bootstrap analyses indicated selected path-specific indirect associations from perceived AIGC saturation to AI content fatigue, satisfaction, and continued viewing intention. Indirect pathways through perceived low-quality prevalence and perceived content overload were supported, whereas those through perceived narrative homogenization were not. The findings indicate that fatigue in AIGC-rich short-video environments is not simply a response to AI-generated content itself. It is more closely related to users' appraisals of content quality, repetitiveness, and cognitive burden. The study contributes to social media fatigue research by conceptualizing AI content fatigue as a content-specific evaluative state and offers implications for platform governance, AIGC labeling, recommendation diversity, and quality-sensitive moderation.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"21 10","pages":"e0360731"},"PeriodicalIF":2.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149207736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}