PLoS ONE最新文献

{"title":"Evaluation of the 22G Franseen needle and 22G Lancet needle for endoscopic ultrasonography-guided tissue acquisition sampling in solid pancreatic lesions: Propensity score weighting.","authors":"Yuki Ishikawa-Kakiya, Hirotsugu Maruyama, Kojiro Tanoue, Akira Higashimori, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Yasuhiro Fujiwara","doi":"10.1371/journal.pone.0322857","DOIUrl":"10.1371/journal.pone.0322857","url":null,"abstract":"<p><strong>Background and aim: </strong>Advantages of endoscopic ultrasonography-guided tissue acquisition (EUS-TA) using a Lancet and Franseen needles have been evaluated and compared. However, little is known about the performance of each needle in diagnostic methods such as cytology and histology or the amount of blood contamination associated with each needle. This study aimed to compare the diagnostic yield and amount of blood contamination between two needles in patients with solid pancreatic lesions.</p><p><strong>Methods: </strong>We collected data of consecutive patients who underwent first time EUS-TA of solid pancreatic lesions at Osaka Metropolitan University between Jan 2006 and Jan 2021 from the electronic medical records. We compared the main outcomes (histological diagnostic accuracy) between the Lancet and Franseen needle groups. The amounts of core tissue and blood contamination were evaluated using a scoring system. This retrospective comparative study was conducted at a single center.</p><p><strong>Results: </strong>A total of 315 patients were divided into the Lancet (n = 200) and Franseen needle group (n = 115). The histological sensitivity and histological diagnostic accuracy of the Franseen needle was higher than that of Lancet needle (82.4% vs. 59.8%, respectively; odds ratio [OR], 2.29; 95% confidence interval [CI], 1.21-4.35; p = 0.011). Multivariate analysis using inverse probability of treat weighting method revealed that the diagnostic performance of the Franseen needle was the significantly higher than the Lancet needle (OR, 2.74; 95% CI, 1.31-5.74; p = 0.007). The core tissue score of 4 was achieved in 53.3% of the Franseen group and 3.3% of the Lancet group (p < 0.001), while high blood contamination was observed in 53.3% and 40%, respectively (p = 0.089).</p><p><strong>Conclusion: </strong>The histological accuracy and the amount of tissue by the Franseen needle are higher than those of the Lancet needle. Franseen needle could achieve high histological diagnostic accuracy even with the same blood contamination rate as that in Lancet needle.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0322857"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of insertion sites for the integrative and conjugative element Tn916 in the Bacillus subtilis chromosome.","authors":"Emily L Bean, Janet L Smith, Alan D Grossman","doi":"10.1371/journal.pone.0318964","DOIUrl":"10.1371/journal.pone.0318964","url":null,"abstract":"<p><p>Integrative and conjugative elements (ICEs) are found in many bacterial species and are mediators of horizontal gene transfer. Tn916 is an ICE found in several Gram-positive genera, including Enterococcus, Staphylococcus, Streptococcus, and Clostridioides (previously Clostridium). In contrast to the many ICEs that preferentially integrate into a single site, Tn916 can integrate into many sites in the host chromosome. The consensus integration motif for Tn916, based on analyses of approximately 200 independent insertions, is an approximately 16 bp AT-rich sequence. Here, we describe the identification and mapping of approximately 105 independent Tn916 insertions in the Bacillus subtilis chromosome. The insertions were distributed between 1,554 chromosomal sites, and approximately 99% of the insertions were in 303 sites and 65% were in only ten sites. One region, between ykuC and ykyB (kre), was a 'hotspot' for integration with ~22% of the insertions in that single location. In almost all of the top 99% of sites, Tn916 was found with similar frequencies in both orientations relative to the chromosome and relative to the direction of transcription, with a few notable exceptions. Using the sequences of all insertion regions, we determined a consensus motif which is similar to that previously identified for C. difficile. The insertion sites are largely AT-rich, and some sites overlap with regions bound by the nucleoid-associated protein Rok, a functional analog of H-NS of Gram-negative bacteria. Rok functions as a negative regulator of at least some horizontally acquired genes. We found that the presence or absence of Rok had little or no effect on insertion site specificity of Tn916.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0318964"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of access to a well-resourced environment on dairy calf cognition and affective state.","authors":"Malina Suchon, Daniel M Weary, Marina A G von Keyserlingk","doi":"10.1371/journal.pone.0323089","DOIUrl":"10.1371/journal.pone.0323089","url":null,"abstract":"<p><p>Dairy calves are often raised without maternal contact and in environments of low complexity. Environments that limit natural behaviors are known to impair cognitive development and affective states. We explored the effect of environmental complexity on one measure of social cognition (the ability to discriminate between conspecifics) and one measure of affective states (sensitivity to reward). Pairs of calves were randomly allocated to either 1) pair housing for 22.5 h/d with 1.5 h of daily access to a well-resourced pen which included 3 other calves and physical devices (Enriched; n = 6 pairs) or, 2) pair housing for 24 h/d (Control; n = 6 pairs). Calves were trained to discriminate between 2 calves in a Y-maze. Twelve of the 24 calves tested met the learning criterion, requiring 15.7 ± 2.59 (mean ± SD) training sessions. Treatment did not affect the number of sessions needed to reach the learning criterion. Calves were then subjected to a Successive Negative Contrast test during which they were trained to approach a 0.5 L milk reward over 3 trials/day for 3 days. On the last training day, latencies of enriched calves increased over daily trials while latencies for control calves were lower and remained relatively consistent, indicative of greater sensitivity to reward. Starting on day 4, the reward was reduced to 0.1L of milk/trial and remained at this level for the next 5 test days. Latency to reach the reward increased across trials within each test day, but no effect of treatment or test day was found. Our findings suggest that calves can discriminate among individuals but learning was not affected by treatments. Calves raised in standard pair housing showed increased sensitivity to reward, consistent with experiencing a more negative emotional state in comparison to calves reared with access to a well-resourced environment.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0323089"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the accuracy of a low-cost external tocodynamometer in a pilot study in Malawi.","authors":"Alex Kortum, Christina Samuel, Theresa Sonka, Lisette Tanner, Benjamin J F Huntley, Ahmed Abouseif, Z Maria Oden, Richard A Schwarz, Jennifer Carns, Suneet P Chauhan, Phylos Bonongwe, Rebecca Richards-Kortum","doi":"10.1371/journal.pone.0323972","DOIUrl":"10.1371/journal.pone.0323972","url":null,"abstract":"<p><p>Uterine contraction monitoring during labor has been linked to improved maternal outcomes. However, performing this monitoring can be challenging for financial and logistical reasons in low resource settings. This proof-of-concept study aimed to compare the accuracy of a low cost external tocodynamometer we developed to that of a commercially available external tocodynamometer. In total, 60 patients with anticipated vaginal deliveries at a hospital in Blantyre, Malawi were enrolled. Both the research device and the commercial device were secured to the patients, and traces were recorded simultaneously from each device. Trace pairs were split into 10 minute segments, and contraction locations were independently annotated on a selection of 75 contemporaneous trace pairs from 38 out of 60 patients by two expert clinicians. In total, 484 contractions were marked on the research device, and 465 contractions were marked on the commercially available device, 312 of which were marked consistently on both devices. The average consistency of marked contractions on the same device between the two observers was 0.89 for the research device compared with 0.84 for the commercially available device. The average consistency between the two devices using a 10-patient rolling average increased from 0.50 at the beginning of the study to 0.64 at the end. The annotated traces from the two devices suggested the same clinical management 72% of the time. The research device displayed reasonable agreement with the commercially available tocodynamometer in detecting contractions. The increase in the measured consistency over the course of the study suggests that improving usability of the device to ensure better positioning on the patient could result in improved performance. Further studies assessing the accuracy and usability of the device are needed.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0323972"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-class rice seed recognition based on deep space and channel residual network combined with double attention mechanism.","authors":"Tingyuan Zhang, Changsheng Zhang, Zhongyi Yang, Meng Wang, Fujie Zhang, Dekai Li, Sen Yang","doi":"10.1371/journal.pone.0322699","DOIUrl":"10.1371/journal.pone.0322699","url":null,"abstract":"<p><p>Accurately recognizing rice seed varieties poses significant challenges due to their diverse morphological characteristics and complex classification requirements. Traditional image recognition methods often struggle with both accuracy and efficiency in this context. To address these limitations, this study proposes the Deep Space and Channel Residual Network with Double Attention Mechanism (RSCD-Net) to enhance the recognition accuracy of 36 rice seed varieties. The core innovation of RSCD-Net is the introduction of the Space and Channel Feature Extraction Residual Block (SCR-Block), which improves inter-class differentiation while minimizing redundant features, thereby optimizing computational efficiency. The RSCD-Net architecture consists of 16 layers of SCR-Blocks, structured into four convolutional stages with 3, 4, 6, and 3 units, respectively. Additionally, a Double Attention Mechanism (A2Net) is incorporated to enhance the network's global receptive field, improving its capacity to distinguish subtle variations among seed types. Experimental results on a self-collected dataset demonstrate that RSCD-Net achieves an average accuracy of 81.94%, surpassing the baseline model by 4.16%. Compared with state-of-the-art models such as InceptionResNetV2, ConvNeXt, MobileNetV3, and Swin Transformer, RSCD Net has improved by 1.17%, 3%, 24.72%, and 13.22%, respectively, showcasing its superior performance. These findings confirm that RSCD-Net provides an effective and efficient solution for rice seed classification, offering a promising reference for addressing similar fine-grained recognition challenges in agricultural applications.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0322699"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expected length of stay in residential aged care facilities in Australia: Assessing the impact of dementia using machine learning.","authors":"Alexander Fracalossi, Jinhui Zhang, Evelyn Lee, Yanlin Shi","doi":"10.1371/journal.pone.0321612","DOIUrl":"10.1371/journal.pone.0321612","url":null,"abstract":"","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0321612"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with female infertility in Ethiopia: A systematic review and meta-analysis.","authors":"Dagne Addisu, Begizew Yimenu Mekuriaw, Besfat Berihun Erega, Wassie Yazie Ferede, Gedefaye Nibret Mihretie, Enyew Dagnew, Assefa Kebie Mitiku, Tegegne Wale Belachew, Maru Mekie","doi":"10.1371/journal.pone.0323181","DOIUrl":"10.1371/journal.pone.0323181","url":null,"abstract":"<p><strong>Background: </strong>Infertility is a significant public health issue that affects couples worldwide. The impacts of infertility is notably higher in Ethiopia due to various factors, such as cultural stigmas surrounding infertility and inadequate infrastructure for diagnosis and treatment. Several fragmented primary studies have assessed factors associated with female infertility in Ethiopia; however, their findings have been controversial and inconclusive. This meta-analysis aimed to identify the factors associated with female infertility in Ethiopia.</p><p><strong>Materials and methods: </strong>A comprehensive search was conducted across multiple databases and search engines, including PubMed, African Journals Online, EBSCO, Google Scholar, and the Directory of Open Access Journals. Additionally, studies were searched from the institutional repositories of Ethiopian universities. Data analysis was performed using Stata version 17. The quality of the included studies was evaluated using the Newcastle-Ottawa quality assessment instrument. Heterogeneity and publication bias were assessed using I² and Egger's tests, respectively. A random effects model was employed to identify factors associated with female infertility. The PROSPERO registration number for this meta-analysis was CRD42024525437.</p><p><strong>Result: </strong>Six studies were included in the analysis. Factors associated with female infertility included having multiple sexual partners (odds ratio [OR] = 4.31, 95% confidence interval [CI] = 3.46-5.16), a history of sexually transmitted diseases (OR = 2.76, 95% CI = 1.61-3.91), alcohol-abusing partners (OR = 1.57, 95% CI = 1.25-1.89), Khat-abusive partners (OR = 1.85, 95% CI = 1.36-2.35), and women's age over 35 years (OR = 2.07, 95% CI = 1.32-2.81).</p><p><strong>Conclusion: </strong>Having multiple sexual partners, a history of sexually transmitted diseases, an alcohol-abusing partner, a khat-abusing partner, and being over the age of 35 were significantly associated with female infertility in Ethiopia. Addressing these risk factors through education, early intervention, lifestyle modifications, and partner involvement can help reduce the burden of infertility and improve the chances of successful conception. The findings underscore the need for further research on understudied factors contributing to female infertility in Ethiopia, including immune function, psychological health, environmental exposures, as well as endocrinological and gynecological conditions.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0323181"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying a system dynamics approach for decision-making in software testing projects.","authors":"Wang Li, Chih-Chiang Fang","doi":"10.1371/journal.pone.0323765","DOIUrl":"10.1371/journal.pone.0323765","url":null,"abstract":"<p><p>Enhancing software quality remains a main objective for software developers and engineers, with a specific emphasis on improving software stability to increase user satisfaction. Developers must balance rigorous software testing with tight schedules and budgets. This often forces them to choose between quality and cost. Traditional approaches rely on software reliability growth models but are often too complex and impractical for testing complex software environments. Addressing this issue, our study introduces a system dynamics approach to develop a more adaptable software reliability growth model. This model is specifically designed to handle the complexities of modern software testing scenarios. By utilizing a system dynamics model and a set of defined rules, we can effectively simulate and illustrate the impacts of testing and debugging processes on the growth of software reliability. This method simplifies the complex mathematical derivations that are commonly associated with traditional models, making it more accessible for real-world applications. The key innovation of our approach lies in its ability to create a dynamic and interactive model that captures the various elements influencing software reliability. This includes factors such as resource allocation, testing efficiency, error detection rates, and the feedback loops among these elements. By simulating different scenarios, software developers and project managers can gain deeper insights into the impact of their decisions on software quality and testing efficiency. This can provide valuable insights for decision-making and strategy formulation in software development and quality assurance.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0323765"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution analysis of the finless porpoises (Neophocaena sp.) and oceanic dolphins (Delphinidae) in the Korean Sea using environmental DNA.","authors":"Sung Bin Lee, Byung Yeop Kim, Won Joon Jung, Han Seok Cho, Kevin Cho, Hyemin Kim, Euna Song, Sib Sankar Giri, Su Jin Jo, Mae Hyun Hwang, Jae Hong Park, Da Sol Park, Eun Jae Park, Ihn-Sil Kwak, Se Chang Park","doi":"10.1371/journal.pone.0322148","DOIUrl":"10.1371/journal.pone.0322148","url":null,"abstract":"<p><p>Environmental DNA (eDNA) serves as a non-invasive tool for monitoring the presence of specific organisms in challenging or hard-to-access areas. We attempted non-invasive monitoring of Korean cetacean species by extracting eDNA from the western and southern seas of the Republic of Korea, as well as around Jeju Island. In the present study, we focused on two representative cetaceans of the Korean Sea: the narrow-ridged finless porpoise (Neophocaena asiaeorientalis sunameri) and oceanic dolphins (Family Delphinidae). When selecting polymerase chain reaction primers, mitochondrial DNA (mtDNA) of N. asiaeorientalis and microsatellite Slo4 of oceanic dolphins were identified as the most effective gene sequences in high abundance in low concentration eDNA samples, using tissue samples for eDNA detection of the target species. A total of 139 samples were collected, and eDNA was detected from finless porpoises (Neophocaena sp.) in 94 samples (68%) and from oceanic dolphins in 50 samples (36%). Significantly, eDNA revealed the considerable presence of finless porpoise around Jeju Island, despite a lack of visual confirmation. In the Yellow Sea, eDNA primarily detected the presence of common dolphin (Delphinus delphis), orca (Orcinus orca), and Indo-Pacific bottlenose dolphin (Tursiops aduncus). Indo-Pacific bottlenose dolphins were identified along the coast of Jeju Island. The value of this research lies in being the first attempt to explore cetacean eDNA across various species in Korea. Further cetacean eDNA research should focus on developing metabarcoding primers capable of detecting a greater variety of cetacean species and primers for detecting specific porpoise species. This study will serve as a valuable reference for future studies.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0322148"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Throwbacks that move us: The dance-inducing power of nostalgic songs.","authors":"Riya K Sidhu, Diana M Urian, Hong Zheng, Jessica A Grahn","doi":"10.1371/journal.pone.0318766","DOIUrl":"10.1371/journal.pone.0318766","url":null,"abstract":"<p><p>The urge to move to music, often referred to as groove, is influenced by various factors, including familiarity with the music. The influence of nostalgia, which involves familiarity but also includes pleasant, sad, and wistful emotions, remains largely unexplored. Here we investigate the impact of both familiarity and nostalgia on the desire to tap, move, and dance along to music. To evoke nostalgia, we selected popular songs from the participants' adolescent years. More recent songs served as a low-nostalgia but familiar control. Participants completed an online experiment, rating songs based on their desire for three different movement types (tap, move, and dance), as well as enjoyment, familiarity, and nostalgia. Nostalgic songs elicited higher desire to move than familiar songs across all three movement categories. Additionally, both familiarity and nostalgia predicted move and tap ratings, but only nostalgia emerged as a predictor for dance ratings. Our results suggest a distinctive role for nostalgia, beyond the influence of familiarity, in motivating the desire to dance.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0318766"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}