PLoS ONE最新文献

{"title":"Deep vein thrombosis in patients with patellar fractures: Assessing incidence rates and identifying risk factors.","authors":"Shuo Yang, Erdong Zhang, Ziping Li, Yubin Long, Yiran Li, Jiaqi Zhang, Fei Wang, Lin Liu, Tao Wang, Junfei Guo, Zhiyong Hou","doi":"10.1371/journal.pone.0316628","DOIUrl":"10.1371/journal.pone.0316628","url":null,"abstract":"<p><strong>Background: </strong>Deep Vein Thrombosis (DVT) represents a significant complication following orthopedic injuries, particularly patellar fractures. Despite the prevalence, comprehensive studies assessing the incidence rates and identifying specific risk factors in patellar fracture patients are limited.</p><p><strong>Methods: </strong>This retrospective analysis reviewed electronic medical records from 3311 patients treated for patellar fractures at two tertiary hospitals between November 2013 and January 2023. The study focused on patient demographics, fracture characteristics, comorbidities, and laboratory parameters to evaluate the incidence and predictors of DVT. DVT prophylaxis measures and diagnostic criteria, including Doppler Ultrasound Scans, were rigorously applied.</p><p><strong>Results: </strong>In patients with patellar fractures, the DVT incidence was 30.8%, with 1,790 clots identified in 1,021 diagnosed individuals, predominantly on the injured side (96.7%), and a minor portion on the uninjured side (3.2%). Key risk factors included older age (P<0.001, OR = 1.038), the presence of open injuries (P = 0.002, OR = 1.521), multiple injuries (P<0.001, OR = 3.623), and prolonged time from injury to surgical treatment (P<0.001, OR = 1.097). Conversely, higher levels of albumin (ALB) (P = 0.029, OR = 0.983) and sodium (Na) (P = 0.028, OR = 0.971) were identified as protective factors against DVT. Besides, ROC curve analysis revealed that the age of 52 years and a duration of 4 days from injury to surgery serve as predictive cut-off values for assessing the risk of DVT.</p><p><strong>Conclusion: </strong>Our study investigates the incidence of thrombosis in patellar fracture patients and identifies key risk factors for DVT, including age, open and multiple injuries, and the time from injury to surgery. Additionally, we highlight sodium and albumin levels as protective factors. By establishing threshold values for age and surgical delay, our findings improve DVT risk assessment, facilitating earlier and more targeted interventions.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 2","pages":"e0316628"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bile acids as biomarkers in carbonized archaeological sediment: Insights from dung burning experiments.","authors":"Basira Mir-Makhamad, Thomas Larsen, Daniel Giddings Vassao, Robert Spengler, Yiming V Wang","doi":"10.1371/journal.pone.0312699","DOIUrl":"10.1371/journal.pone.0312699","url":null,"abstract":"<p><p>Bile acids are increasingly used as fecal biomarkers for studying archeology, environmental pollution, paleoeconomy, and human-animal interactions. Exclusively synthesized by vertebrates, bile acids are more resistant to diagenetic degradation than other steroidal biomarkers. Although bile acids have been detected and analyzed in archaeological sediments, particularly in contexts where dung may have been used as fuel, their preservation after burning is poorly understood. In this study, we conducted controlled experiments on modern cattle dung to investigate the tolerance of bile acid to high temperatures (125°C, 233°C, 341°C, and 449°C). Bile acids were quantified before and after burning via High-Performance Liquid Chromatography coupled with Electrospray Ionization-Mass Spectrometry (HPLC-EI-MS). Our results indicate that elevated temperatures destabilize most bile acids to varying degrees. Primary and secondary bile acids showed moderate heat tolerance, persisting at reduced concentrations after exposure to the maximum furnace and open-air temperatures. In contrast, oxo-bile acids exhibited lower thermal stability and disappeared at exposure above 233°C. Open-air fires led to more significant overall bile acid loss than the furnace conditions, likely due to the higher temperatures. However, incompletely burned dung fragments from the cooler periphery of the fire pits, retained higher bile acid concentrations than fully combusted ashes. Our findings suggest that high temperatures complicate the use of bile acid profiles to distinguish species of origin. These persistent bile acids can, in archaeological contexts, provide valuable insights into past resource utilization, seasonal fuel use, mobility patterns, and environmental reconstruction.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 2","pages":"e0312699"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of novel proteins associated with intelligence by integrating genome-wide association data and human brain proteomics.","authors":"Zheng Zhang, Yousong Zhu, Junlong Zhang, Wenbin He, Cheng Han","doi":"10.1371/journal.pone.0319278","DOIUrl":"10.1371/journal.pone.0319278","url":null,"abstract":"<p><p>While genome-wide association studies (GWAS) have identified genetic variants associated with intelligence, their biological mechanisms remain largely unexplored. This study aimed to bridge this gap by integrating intelligence GWAS data with human brain proteomics and transcriptomics. We conducted proteome-wide (PWAS) and transcriptome-wide (TWAS) association studies, along with enrichment and protein-protein interaction (PPI) network analyses. PWAS identified 44 genes in the human brain proteome that influence intelligence through protein abundance regulation (FDR P <  0.05). Causal analysis revealed 36 genes, including GPX1, involved in the cis-regulation of protein abundance (P <  0.05). In independent PWAS analyses, 17 genes were validated, and 10 showed a positive correlation with intelligence (P <  0.05). TWAS revealed significant SNP-based heritability for mRNA in 28 proteins, and cis-regulation of mRNA levels for 20 genes was nominally associated with intelligence (FDR P <  0.05). This study identifies key genes that bridge genetic variants and protein-level mechanisms of intelligence, providing novel insights into its biological pathways and potential therapeutic targets.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 2","pages":"e0319278"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of layering characteristics on compressive mechanical properties and damage mechanisms of rocks: Experiments and models.","authors":"Chong Chen, Aixiang Wu, Shaoyong Wang, Wutian Gong, Wei Sun, Tong Gao","doi":"10.1371/journal.pone.0318603","DOIUrl":"10.1371/journal.pone.0318603","url":null,"abstract":"<p><p>The investigation of layered rock mechanical properties is important for rock stability analysis. To examine the effects of layer inclination angle (LIA) and layer thickness (LT) on the compressive mechanical properties and damage mechanism of layered rock, this paper proposes a new method of preparing layered rock specimens using similar materials and conducting uniaxial compression tests. At the same time, PFC2D numerical analysis software is used to establish the discrete element numerical model of layered rock under uniaxial compression to deepen its microscopic damage mechanism. The results show that the LIA significantly affects the anisotropic mechanical properties of the rock, and the different LIA lead to significant differences in the crack extension paths and failure modes, which can be summarized into four types of cracks and four failure modes. The increase in LT under the effect of different LIA shows different mechanisms of action, which is enhanced in 0° and 90°, weakened in 45° and 75°, and insignificant in 15°, 30° and 60°. In addition, the expansion of micro-cracks in layered rocks are all dominated by interlayer shear cracks first, and then conduct to the rock portion to tensile cracks. The findings of this research offer valuable insights for stability assessment and design of layered rock structures in engineering applications.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 2","pages":"e0318603"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Parkinson's disease trajectory using clinical and functional MRI features: A reproduction and replication study.","authors":"Elodie Germani, Nikhil Bhagwat, Mathieu Dugré, Rémi Gau, Albert A Montillo, Kevin P Nguyen, Andrzej Sokolowski, Madeleine Sharp, Jean-Baptiste Poline, Tristan Glatard","doi":"10.1371/journal.pone.0317566","DOIUrl":"10.1371/journal.pone.0317566","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a common neurodegenerative disorder with a poorly understood physiopathology and no established biomarkers for the diagnosis of early stages and for prediction of disease progression. Several neuroimaging biomarkers have been studied recently, but these are susceptible to several sources of variability related for instance to cohort selection or image analysis. In this context, an evaluation of the robustness of such biomarkers to variations in the data processing workflow is essential. This study is part of a larger project investigating the replicability of potential neuroimaging biomarkers of PD. Here, we attempt to fully reproduce (reimplementing the experiments with the same methods, including data collection from the same database) and replicate (different data and/or method) the models described in (Nguyen et al., 2021) to predict individual's PD current state and progression using demographic, clinical and neuroimaging features (fALFF and ReHo extracted from resting-state fMRI). We use the Parkinson's Progression Markers Initiative dataset (PPMI, ppmi-info.org), as in (Nguyen et al., 2021) and aim to reproduce the original cohort, imaging features and machine learning models as closely as possible using the information available in the paper and the code. We also investigated methodological variations in cohort selection, feature extraction pipelines and sets of input features. Different criteria were used to evaluate the reproduction attempt and compare the results with the original ones. Notably, we obtained significantly better than chance performance using the analysis pipeline closest to that in the original study (R2 > 0), which is consistent with its findings. In addition, we performed a partial reproduction using derived data provided by the authors of the original study, and we obtained results that were close to the original ones. The challenges encountered while attempting to reproduce (fully and partially) and replicating the original work are likely explained by the complexity of neuroimaging studies, in particular in clinical settings. We provide recommendations to further facilitate the reproducibility of such studies in the future.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 2","pages":"e0317566"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use and impact of digital technology in supporting health providers deliver care in low- and low-middle-income countries: A systematic review protocol.","authors":"Adam T Craig, Harriet Lawford, Maggie Miller, Liuyi Chen-Cao, Leanna Woods, Siaw-Teng Liaw, Myron A Godinho","doi":"10.1371/journal.pone.0319190","DOIUrl":"10.1371/journal.pone.0319190","url":null,"abstract":"<p><strong>Background: </strong>Healthcare providers are critical to the successful, sustainable and impactful implementation of digital health. Despite the growing interest, Digital Health Innovations (DHIs) are often implemented without sufficient evidence, leading to numerous short-lived projects and a limited understanding of their impact on health systems and outcomes. In 2023, the World Health Organization (WHO) introduced a new Classification of Digital Health Interventions, identifying four core DHI user groups. This review aims to synthesise evidence on the impact of DHIs designed for one of these user groups-healthcare providers-on delivering health services in low- and lower-middle-income countries (LLMICs).</p><p><strong>Methods: </strong>We will conduct an umbrella review, analysing systematic reviews on DHIs for healthcare providers. Data will be extracted using deductive coding before being thematically analysed according to the 11 DHIs for service providers outlined in the WHO's 2023 Classification.</p><p><strong>Discussion: </strong>This umbrella review will explore, synthesise, and evaluate the quality of evidence on how healthcare providers in LLMICs utilise DHIs to address service delivery challenges and their effectiveness. To our knowledge, this is the first comprehensive synthesis of evidence focused on DHIs designed for use by healthcare providers in LLMICs. It is also the first review to align with WHO's taxonomy for DHIs, as outlined in the WHO Classification of Digital Interventions, Services and Applications in Health.</p><p><strong>Systematic review registration: </strong>The protocol is being registered in PROSPERO (ID: CRD42024586285).</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 2","pages":"e0319190"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PRECISION study protocol: Can cervical stiffness in the second trimester predict preterm birth in high-risk singleton pregnancies? A feasibility, cohort study.","authors":"Elizabeth Medford, Steven Lane, Andrew Sharp, Angharad Care","doi":"10.1371/journal.pone.0316297","DOIUrl":"10.1371/journal.pone.0316297","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality. More than 13 million babies are affected globally every year and PTB will contribute to over 900,000 deaths. In the UK, PTB affects 8% of pregnancies and costs more than £260 million annually in neonatal care. Identifying those at risk of this devastating complication of pregnancy and implementing preventative treatment remains a maternal health priority. The mainstay of PTB prevention has been assessment of cervical length (CL) in women at high-risk of PTB. However, CL has limitations, namely it is invasive, user dependent and varies over time through pregnancy. Importantly, not all those who are high-risk with a short CL will subsequently deliver preterm and CL screening doesn't identify a sub-set of women who have a spontaneous PTB without a short cervix. Therefore, existing care pathways for managing PTB can potentially benefit from additional assessments of risk. Novel ways of assessing cervical structure and function may improve our ability to predict spontaneous PTB and refine preventative intervention. This feasibility study will explore the use of a new antenatal test of cervical stiffness for assessing risk of spontaneous PTB in a high-risk singleton population.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;PRECISION is a single site prospective, feasibility, cohort study of asymptomatic women with singleton pregnancies at high risk for spontaneous PTB attending an inner-city tertiary maternity hospital in the UK. All study participants will be undergoing routine screening and management of PTB as per local guidance (NICE/Saving Babies Lives guidance) including CL screening with transvaginal ultrasound. Cervical stiffness will be assessed using the Pregnolia System; a novel, licensed, CE-marked, aspiration-based device. A measurement is obtained by applying the device directly to the anterior lip of the cervix, visualised via placement of a speculum, and gives a quantitative assessment of cervical stiffness represented as the Cervical Stiffness Index (CSI, in mbar). Participants will undergo cervical stiffness assessments at up to three timepoints in the second trimester between 14+0 weeks and 25+6 weeks gestation. The cervical stiffness index data will be paired with routine PTB clinic CL measurements taken at the same time points. The primary outcome will focus on the feasibility of using this novel antenatal test in this high-risk population and explore any association between cervical stiffness and PTB.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;This is an exploratory study to assess the use of this novel device in clinical practice. Direct comparison between cervical stiffness assessment using the Pregnolia System and CL assessment will determine the acceptability of this new assessment in this population, as well as explore its potential association with PTB. Our findings from this feasibility study will provide data on the potential of this nove","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 2","pages":"e0316297"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and properties of isocyanate self-healing microcapsule cement-based material.","authors":"Yanqing Xian","doi":"10.1371/journal.pone.0314696","DOIUrl":"10.1371/journal.pone.0314696","url":null,"abstract":"<p><p>Self-healing microcapsule cement-based materials autonomously repair microcracks within the matrix. This study utilized the interfacial polymerization method to prepare isocyanate microcapsules, incorporating montmorillonite to enhance the wall material. The optimized synthesis conditions were established as follows: a reaction time of 2 hours at 50°C, using 3g of wall material, 13.5g of core material, and 1% montmorillonite, achieving a core material content of 61.5%. Both micro and macro analyses confirm the microcapsules' excellent alkaline resistance and compatibility with cement-based materials. The ideal microcapsule concentration was determined to be 4%, which increased the compressive strength recovery rate of the self-healing mortar to 117.38%.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 2","pages":"e0314696"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A DNA barcode library for Culex mosquitoes (Diptera: Culicidae) of South America with the description of two cryptic species of subgenus Melanoconion.","authors":"Stanislas Talaga, Amandine Guidez, Benoît de Thoisy, Anne Lavergne, Romuald Carinci, Pascal Gaborit, Jean Issaly, Isabelle Dusfour, Jean-Bernard Duchemin","doi":"10.1371/journal.pone.0310571","DOIUrl":"10.1371/journal.pone.0310571","url":null,"abstract":"<p><p>Among mosquitoes (Diptera: Culicidae), the genus Culex Linnaeus is one of the most diverse in the world and includes numerous known vector species of parasites and viruses to humans. Morphological identification of Culex species is notoriously difficult and relies mostly on the examination of properly dissected male genitalia which largely prevents female and immature identification during entomological, ecological or arboviral surveys. The aims of this study were (i) to establish a DNA barcode library for Culex mosquitoes of French Guiana based on the mitochondrial gene cytochrome c oxidase I (COI) marker, (ii) to compare three approaches of molecular delimitation of species to morphological identification, (iii) to test the effectiveness of the COI marker at a broader geographical scale across South America, and (iv) to discuss the internal classification of the genus Culex as regard to our phylogenetic analysis. Mosquitoes used in this study were sampled in French Guiana between 2013 and 2023. We provide 246 COI sequences for 90 morphologically identified species of Culex, including five new country records and two newly described species. Overall, congruence between morphological identification and molecular delimitations using the COI barcode was high. The Barcode of Life Data clustering approach into Barcode Index Numbers gives the best result in terms of species delimitation. Inconsistencies between morphological identification and molecular delimitation can be explained by introgression, incomplete lineage sorting, imperfect taxonomy or the effect of geographical gap in sampling. This increases by almost two-fold the number of mosquito species for which a DNA barcode is available in French Guiana, including 75% of the Culex species currently known in the territory. Finally, this study confirms the usefulness of the COI barcode in identifying Culex of South America, but also points the limits of this marker for some groups of species within the subgenera Culex and Melanoconion.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 2","pages":"e0310571"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Back to normal? The health care situation of home care receivers across Europe during the COVID-19 pandemic and its implications on health.","authors":"Michael Bergmann, Melanie Wagner","doi":"10.1371/journal.pone.0319693","DOIUrl":"10.1371/journal.pone.0319693","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0287158.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 2","pages":"e0319693"},"PeriodicalIF":2.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}