PLoS ONE最新文献

{"title":"Factors associated with vitamin D levels in Mongolian patients with multiple sclerosis.","authors":"Myadagmaa Jaalkhorol, Amarsaikhan Dashtseren, Gantuya Magnaibayar, Badrangui Bat-Orgil, Ikuo Tsunoda, Shiirevnyamba Avirmed, Stefania Iaquinto, Viktor von Wyl","doi":"10.1371/journal.pone.0317279","DOIUrl":"https://doi.org/10.1371/journal.pone.0317279","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) onset is caused by genetic and environmental factors. Vitamin D has been identified as contributing environmental risk factor, with higher prevalence at latitudes further from the equator. Mongolia, at 45°N, has limited sunlight exposure, increasing the population's risk for vitamin D deficiency.</p><p><strong>Objectives: </strong>To compare vitamin D levels between persons with MS (pwMS) and persons without MS and to identify factors associated with low vitamin D.</p><p><strong>Methods: </strong>We investigated associations with vitamin D levels using data from MS cases and controls from Mongolia. We used linear mixed-effects regression with fixed effects (case status, sociodemographics, and predefined variables) and participant-specific random intercepts.</p><p><strong>Results: </strong>Of 62 participants (31 pwMS, 31 controls), pwMS had lower summer [median 23.00 ng/ml (interquartile range 11.30-31.50) vs. 25.00 ng/ml (19.25-32.00)] and winter vitamin D levels [21.00 ng/ml (10.60-27.60) vs. 23.50 ng/ml (15.55-28.60)], with a smaller seasonal decline. Vitamin D deficiency was more prevalent in pwMS. None of these findings reached statistical significance. Winter season and being breastfed as a child were associated with significantly lower vitamin D levels.</p><p><strong>Conclusion: </strong>Vitamin D deficiency was common among pwMS, which could be influenced by behavioural factors. These findings may inform more targeted recommendations for pwMS to maintain sufficient vitamin D levels.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0317279"},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of five dynamic models in predicting tuberculosis incidence in three prisons in Thailand.","authors":"Nithinan Mahawan, Thanapoom Rattananupong, Puchong Sri-Uam, Wiroj Jiamjarasrangsi","doi":"10.1371/journal.pone.0318089","DOIUrl":"https://doi.org/10.1371/journal.pone.0318089","url":null,"abstract":"<p><p>This study examined the ability of the following five dynamic models for predicting pulmonary tuberculosis (PTB) incidence in a prison setting: the Wells-Riley equation, two Rudnick & Milton-proposed models based on air changes per hour and liters per second per person, the Issarow et al. model, and the applied susceptible-exposed-infected-recovered (SEIR) tuberculosis (TB) transmission model. This 1-year prospective cohort study employed 985 cells from three Thai prisons (one prison with 652 cells as the in-sample, and two prisons with 333 cells as the out-of-sample). The baseline risk of TB transmission for each cell was assessed using the five dynamic models, and the future PTB incidence was calculated as the number of new PTB cases per cell and the number of new PTB cases per 1,000 person-years (incidence rate). The performance of the dynamic models was assessed by a four-step standard assessment procedure (including model specification tests, in-sample model fitting, internal validation, and external validation) based on the Negative Binomial Regression model. A 1% increase in baseline TB transmission probability was associated with a 3%-7% increase in future PTB incidence rate, depending on the dynamic model. The Wells-Riley model exhibited the best performance in terms of both internal and external validity. Poor goodness-of-fit was observed in all dynamic models (chi-squared goodness-of-fit tests of 70.75-305.1, 8 degrees of freedom, p < .001). In conclusion, the Wells-Riley model was the most appropriate dynamic model, especially for large-scale investigations, due to its fewer parameter requirements. Further research is needed to confirm our findings and gather more data to improve these dynamic models.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0318089"},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance angiography in diagnostic long-term follow-up of primary patency of the MOTIV drug-eluting bioresorbable vascular scaffold in the region below the knee: 5 years of experience.","authors":"Christian Nasel, Mario Kirschner, Karoline Rizzi, Nicola Schweinhammer, Ewald Moser","doi":"10.1371/journal.pone.0313696","DOIUrl":"https://doi.org/10.1371/journal.pone.0313696","url":null,"abstract":"<p><strong>Purpose: </strong>Treatment of peripheral artery disease (PAD) in the region below the knee (BTK) is dissatisfying as failure of treated target lesions (TLF) is frequent and diagnostic imaging is often challenging. In the BTK-region metallic drug-eluting stents (mDES) yielded best results concerning primary patency (PP), but also annihilate signal in magnetic resonance angiography (MR-A). A recently introduced non-metallic drug eluting bioresorbable Tyrocore® vascular scaffold (deBVS), that offers an option for re-treatment of lesions due to its full degradation within 3-4 years after placement, was investigated with respect to its compatibility with MR-A to unimpededly depict previously treated target lesions.</p><p><strong>Methods: </strong>Patency of the deBVS in the BTK-region was assessed retrospectively using contrast enhanced MR-A of the lower limbs in patients with PAD of Lafontaine-grades II-IV (n = 19). Clinically driven MR-A censoring was triggered by an assumed target lesion failure (CD-TLF), which served to compute the probability of PP during the observation period of 5 years. Compatibility of this particular deBVS with MRI was additionally proven via in-vitro experiments.</p><p><strong>Results: </strong>The scaffold was found to be fully compatible with MRI. The normalised intra-luminal signal measured in MR-A increased significantly after successful deBVS-placement. The retrospective 5-years PP-probability was 0.87 (CI95%: [0.71,1.0]) with 2 stent-occlusions observed after 90 days. No major adverse events occurred.</p><p><strong>Conclusion: </strong>Assessment of PAD in the BTK-region after placement of the Tyrocore®-deBVS using MRA is feasible. The promising high PP-probability after 5-years and the persistent full interpretability of treated target lesions by MR-A after stent-placement encourage further prospective assessment of this deBVS in treatment of PAD in the BTK-region.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0313696"},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial-temporal evolution of the allometric relationship between urban economic and health resources in the Yangtze River Delta urban agglomeration.","authors":"Deng Jing, Qianwen Song, Huan Liu, Zicheng Jiang, Xingxing He, Chengzhi Ge, Dexun Li","doi":"10.1371/journal.pone.0314315","DOIUrl":"https://doi.org/10.1371/journal.pone.0314315","url":null,"abstract":"<p><p>The evolution of the spatiotemporal relationship between urban economic growth and health resources within the Yangtze River Delta urban agglomeration provides an important context for understanding the regional development dynamics in China. Previous studies focused on equity in health-resource allocation and service efficiency, often overlooking the allometric growth relationships between health resources and economic variables. This study employs an allometric growth model to elucidate the changing interactions between the number of medical beds, doctors, and urban economic indicators in the Yangtze River Delta region from 2009 to 2022. Employing Zipf's law and allometric growth modeling, this study analyzed growth trends and revealed significant differences in resource allocation and size changes over time. The main findings suggest that, although resource centralization is a general trend, differences persist, especially in less economically developed regions. This study innovatively introduces an allometric growth model that offers a new perspective on understanding the mechanisms of regional health-resource growth and underscores the significant influence of economic factors on health-resource allocation. This study significantly contributes to the sustainability of urban health systems and provides theoretical support for policy formulations aimed at optimizing the allocation of health resources and strengthening regional economic strategies in the Yangtze River Delta region.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0314315"},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The measurement reliability and equivalence of print versus online versions of the Youth Activity Profile.","authors":"Yang Bai, Philip M Dixon, Pedro F Saint-Maurice, Paul R Hibbing, Gabriella M McLoughlin, Michael Pereira da Silva, Gregory J Welk","doi":"10.1371/journal.pone.0312254","DOIUrl":"https://doi.org/10.1371/journal.pone.0312254","url":null,"abstract":"<p><strong>Purpose: </strong>The Youth Activity Profile (YAP) is a 7-day self-report designed to quantify physical activity and sedentary behaviors among youth. This study evaluated the reliability of the online version of the YAP and equivalence with the paper-based version.</p><p><strong>Method: </strong>A total of 2,490 participants from 17 schools in Iowa and Texas completed the YAP. Each classroom was randomly assigned to complete either the print or online version twice. A variance components model was used to assess the test-retest reliability and equivalence testing was also applied.</p><p><strong>Results: </strong>Both paper and online versions had similar reliability for the PA estimates in school (ICCprint = 0.69-0.91; ICConline = 0.54-0.84), at home (ICCprint = 0.72-0.83; ICConline = 0.64-0.94), PA at weekend (ICCprint = 0.33-0.72; ICConline = 0.39-0.70), and SB (ICCprint = 0.69-0.90; ICConline = 0.66-0.80). The two versions were statistically equivalent for most YAP items except for recess.</p><p><strong>Conclusion: </strong>The online YAP appears to be a reliable assessment of physical activity and sedentary behavior in youth populations.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0312254"},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The QUIC-SP: A Spanish language tool assessing unpredictability in early life is linked to physical and mental health.","authors":"Sabrina R Liu, Natasha A Bailey, Sara Romero-González, Amy Moors, Belinda Campos, Elysia Poggi Davis, Laura M Glynn","doi":"10.1371/journal.pone.0298296","DOIUrl":"https://doi.org/10.1371/journal.pone.0298296","url":null,"abstract":"<p><p>Accumulating evidence indicates that unpredictable signals in early life represent a unique form of adverse childhood experiences (ACEs) associated with disrupted neurodevelopmental trajectories in children and adolescents. The Questionnaire of Unpredictability in Childhood (QUIC) was developed to assess early life unpredictability [1], encompassing social, emotional, and physical unpredictability in a child's environment, and has been validated in three independent cohorts. However, the importance of identifying ACEs in diverse populations, including non-English speaking groups, necessitates translation of the QUIC. The current study aims to translate and validate a Spanish language version of the QUIC (QUIC-SP) and assess its associations with mental and physical health. Spanish-speaking participants (N = 285) were recruited via the online market crowdsourcing platform, Amazon Mechanical Turk (MTurk), and completed an online survey that included the QUIC-SP and validated Spanish language assessments of physical and mental health. The QUIC-SP demonstrated excellent psychometric properties and similar mean scores, endorsement rates, and internal reliability to the English language version, thus establishing its validity among Spanish-speaking adults. Higher QUIC-SP scores, indicating greater unpredictability in early life, predicted increased symptoms of anxiety, anhedonia, depression, and poorer physical health. Given significant racial and ethnic disparities in health, the QUIC-SP may serve as a valuable tool to address the public health consequences of ACEs among Spanish-speaking populations.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0298296"},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderating role of age in the relationship between ingroup range and intention to help during the COVID-19 pandemic.","authors":"Inyeong Lee, Hyekyung Park","doi":"10.1371/journal.pone.0316316","DOIUrl":"https://doi.org/10.1371/journal.pone.0316316","url":null,"abstract":"<p><p>This study explored the relationship between the ingroup range of individuals and their willingness to assist various social groups during the COVID-19 pandemic and whether or not age moderates this relationship. A total of 291 South Koreans (Mage = 31.91 years, SD = 11.99) participated in an online survey and provided data on ingroup range, intention to provide help, and age. The results demonstrated that individuals with a broader ingroup range displayed a stronger willingness to distribute quarantine supplies for COVID-19 across diverse social groups (β = .12, p < .05). This finding aligned with the ingroup bias phenomenon, in which individuals tend to favor one's group. Importantly, age moderated the association between ingroup range and willingness to help (B = -.19, p < .05). Specifically, the intention of younger individuals (θX → Y|(M = -11.985) = 4.40, CI = 1.79-7.01) and middle-aged individuals (θX → Y|(M = .000) = 2.14, CI = .31-3.98) to assist diverse social groups significantly varied according to their ingroup range, whereas no such relationship existed among older individuals (θX → Y|(M = 11.985) = -.11, CI = -2.64-2.42). We provided an in-depth discussion into the potential reasons that underlie the stronger willingness of older individuals to extend aid beyond their ingroup range during the pandemic compared with those of younger individuals. We then suggested strategies for encouraging acts of prosociality during crises, such as the COVID-19 pandemic, which particularly emphasize the pattern observed in younger participants with a narrow ingroup range.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0316316"},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between vitamin A and myopia: A population-based study.","authors":"Yeo Jin Lee, Donghyun Jee","doi":"10.1371/journal.pone.0316438","DOIUrl":"https://doi.org/10.1371/journal.pone.0316438","url":null,"abstract":"<p><strong>Purpose: </strong>We sought to evaluate the relationship between blood vitamin A levels and myopia in adults aged ≥20 years in Korea.</p><p><strong>Methods: </strong>We collected data of 15,899 participants aged ≥20 years from the Korean National Health and Nutrition Examination Survey. Participants underwent refraction tests to identify myopia and high myopia, and their blood pressure and obesity levels were measured. Blood tests were conducted to assess vitamin A, fasting blood glucose, triglyceride, and total cholesterol levels. Blood vitamin A levels were classified into quartiles.</p><p><strong>Results: </strong>After adjusting for confounding variables like age, sex, income, education, hypertension, diabetes, and obesity, the odds ratio (OR) of blood vitamin A in the second quartile for myopia was 0.66, while the OR in the fourth quartile was 0.74 (P for trend < 0.001). Among women, the ORs for myopia in the second and third quartiles of blood vitamin A levels were 0.48 (95% confidence interval [CI], 0.35-0.66) and 0.67 (95% CI, 0.49-0.90), respectively (P for trend < 0.001). In men, the ORs for high myopia in the second, third, and fourth quartiles of blood vitamin A levels were 0.05 (95% CI, 0.004-0.58), 0.15 (95% CI, 0.024-0.91), and 0.05 (95% CI, 0.008-0.364), respectively (P for trend < 0.001).</p><p><strong>Conclusion: </strong>An inverse relationship was observed between higher blood vitamin A levels and the prevalence of myopia. Notably, higher blood vitamin A levels were associated with a lower prevalence of high myopia in men and a lower prevalence of myopia in women.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0316438"},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The type of diet consumed during prepuberty modulates plasma cholesterol, hepatic LXRα expression, and DNA methylation and hydroxymethylation during adulthood in male rats.","authors":"Ana Aguilar-Lozano, Berenice Palacios-González, Martha Guevara-Cruz, Armando R Tovar, Alam Palma-Guzman, Lilia G Noriega","doi":"10.1371/journal.pone.0315197","DOIUrl":"https://doi.org/10.1371/journal.pone.0315197","url":null,"abstract":"<p><p>Childhood obesity increases the risk of developing metabolic diseases in adulthood, since environmental stimuli during critical windows of development can impact on adult metabolic health. Studies demonstrating the effect of prepubertal diet on adult metabolic disease risk are still limited. We hypothesized that a prepubertal control diet (CD) protects the adult metabolic phenotype from diet-induced obesity (DIO), while a high-fat diet (HFD) would predispose to adult metabolic alterations. Sprague-Dawley male rats were fed either a CD or a HFD during the prepubertal period (day 30-40 of age) and subsequently a chronic HFD or CD, respectively, until adulthood (day 220 of age). As controls, rats aged 30 days were exclusively fed a CD or a HFD until adulthood. Body weight and composition, metabolic rate, biochemical and hormonal plasma measurements, hepatic gene expression and methylation and hydroxymethylation levels were analyzed at ages 30, 40 and 220 days. The prepubertal CD prevented fat mass accumulation, lean mass loss and metabolic inflexibility, showed lower insulin, leptin and cholesterol concentrations in adulthood despite the chronic HFD. Notably, the prepubertal CD led to higher hepatic Lxrα expression, lower hepatic global DNA methylation and higher hydroxymethylation in adulthood despite a chronic HFD. Conversely, a prepubertal HFD decreased adult metabolic flexibility, increased serum cholesterol, and decreased Lxrα expression and global DNA hydroxymethylation, while also increasing DNA methylation levels despite a chronic CD. In summary, a prepubertal CD protected the adult metabolic phenotype from high cholesterol concentrations associated with increased hepatic Lxrα expression and lower hepatic global DNA methylation in adulthood, despite exposure to a chronic HFD. Conversely, a prepubertal HFD altered the adult metabolic phenotype.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0315197"},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real sounds influence postural stability in people with vestibular loss but not in healthy controls.","authors":"Anat V Lubetzky, Maura Cosetti, Daphna Harel, Marlee Sherrod, Zhu Wang, Agnieszka Roginska, Jennifer Kelly","doi":"10.1371/journal.pone.0317955","DOIUrl":"https://doi.org/10.1371/journal.pone.0317955","url":null,"abstract":"<p><strong>Objective: </strong>What we hear may influence postural control, particularly in people with vestibular hypofunction. Would hearing a moving subway destabilize people similarly to seeing the train move? We investigated how people with unilateral vestibular hypofunction and healthy controls incorporated broadband and real-recorded sounds with visual load for balance in an immersive contextual scene.</p><p><strong>Design: </strong>Participants stood on foam placed on a force-platform, wore the HTC Vive headset, and observed an immersive subway environment. Each 60-second condition repeated twice: static or dynamic visual with no sound or static white noise or real recorded subway station sounds [real] played from headphones.</p><p><strong>Setting: </strong>Human motion laboratory.</p><p><strong>Participants: </strong>41 healthy controls (mean age 52 years, range 22-78) and 28 participants with unilateral peripheral vestibular hypofunction (mean age 61.5, 27-82).</p><p><strong>Main outcome measures: </strong>We collected center-of-pressure (COP, anterior-posterior, medio-lateral) from the force-platform and head (anterior-posterior, medio-lateral, pitch, yaw, roll) from the headset and quantified root mean square velocity (cm/s or rad/s).</p><p><strong>Results: </strong>Adjusting for age, the vestibular group showed significantly more sway than controls on: COP medio-lateral (no sound or real with static or dynamic visual); COP anterior-posterior (only on dynamic visuals in the presence of either sound); head medio-lateral and anterior-posterior (all conditions), head pitch and yaw (only on dynamic visuals in the presence of either sound). A significant increase in sway with sounds was observed for the vestibular group only on dynamic visuals COP anterior-posterior and head yaw (real) and head anterior-posterior and pitch (either sound).</p><p><strong>Conclusions: </strong>The addition of auditory stimuli, particularly contextually-accurate sounds, to a challenging, standing balance task in real-life simulation increased sway in people with vestibular hypofunction but not in healthy controls.</p><p><strong>Trial registration: </strong>Clinical trial registrationThis study was registered on clinicaltrials.gov at the following link: https://clinicaltrials.gov/study/NCT04479761.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0317955"},"PeriodicalIF":2.9,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}