PLoS ONE最新文献

{"title":"PLANES: Plausibility analysis of epidemiological signals.","authors":"V P Nagraj, Amy E Benefield, Desiree Williams, Stephen D Turner","doi":"10.1371/journal.pone.0320442","DOIUrl":"10.1371/journal.pone.0320442","url":null,"abstract":"<p><p>Methods for reviewing epidemiological signals are necessary to building and maintaining data-driven public health capabilities. We have developed a novel approach for assessing the plausibility of infectious disease forecasts and surveillance data. The PLANES (PLausibility ANalysis of Epidemiological Signals) methodology is designed to be multi-dimensional and flexible, yielding an overall score based on individual component assessments that can be applied at various temporal and spatial granularities. Here we describe PLANES, provide a demonstration analysis, and discuss how to use the open-source rplanes R package. PLANES aims to enable modelers and public health end-users to evaluate forecast plausibility and surveillance data integrity, ultimately improving early warning systems and informing evidence-based decision-making.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0320442"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family's perceptions of their members who use nyaope in Tshwane, South Africa.","authors":"Doudou K Nzaumvila, Robert Mash, Toby Helliwell","doi":"10.1371/journal.pone.0318794","DOIUrl":"10.1371/journal.pone.0318794","url":null,"abstract":"<p><strong>Introduction: </strong>Over the last two decades, nyaope use has evolved to become a prominent substance use disorder in South Africa, posing a significant public health burden. The majority of users are young people who are solely concerned with their next nyaope joint. This study aimed to explore the perception of family members on the factors associated with the use of and dependency on nyaope.</p><p><strong>Methods: </strong>This was a descriptive exploratory qualitative study conducted in Tshwane, South Africa. Data were collected from 32 family members of Nyaope users via three focus group interviews conducted by a retired psychologist nurse in the three townships of Tshwane.</p><p><strong>Results: </strong>The findings revealed a complex and interconnected web of elements that shape the journey of individuals from the onset of nyaope use to the point of dependence and eventual departure from their family homes. Rather than following a linear path of events, this pathway is characterised by a dynamic interplay of seven distinct themes, namely concealed nyaope use, family concerns and suspicions regarding nyaope use, confirmation of nyaope use, possible reasons for using nyaope, barriers to obtaining assistance for nyaope users, family distress, and the transition from home to a life on the streets.</p><p><strong>Conclusion: </strong>Most users ended up being disconnected from their families. Family members' opinions noted that the problem is perceived to be a web of elements working together rather than a linear path of events. The findings have implications for substance use services, social services, health and police services as well as schools.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0318794"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and determinants of depression and/or anxiety among adults using Kenya Demographic and Health Survey of 2022: Multilevel logistic regression analysis.","authors":"Mamaru Melkam, Setegn Fentahun, Girmaw Medfu Takelle, Gidey Rtbey, Fantahun Andualem, Girum Nakie, Gebresilassie Tadesse, Yilkal Abebaw Wassie","doi":"10.1371/journal.pone.0319571","DOIUrl":"10.1371/journal.pone.0319571","url":null,"abstract":"<p><strong>Introduction: </strong>Depression and/or anxiety can be persistent or recurrent significantly affecting a person's capacity to manage daily life, job, and school. The burden of depression and anxiety is rising from time to time, with serious consequences for overall health. Depression and anxiety are crippling conditions that can impact individuals of the whole community. Despite the high prevalence of depression and/or anxiety few studies were conducted that show the diagnosis levels of depression and/or anxiety in the community, particularly in Kenya. Therefore, this study aims to determine the prevalence of depression and/or anxiety and their determinant factors among adults in Kenya using data sourced from the 2022 Kenya Demographic and Health Survey.</p><p><strong>Method: </strong>The Kenya demographic and health survey of 2022 data were used for this secondary data analysis in 2024. The survey included age groups ranging from 15 to 49, with a total sample size of 16,901 participants. Multilevel analysis was used to determine the prevalence of depression and/or anxiety with determinant factors at the 95% CI.</p><p><strong>Results: </strong>The overall prevalence of depression and/or anxiety was 3.84% with a 95% CI of (3.56, 4.14). Of this, 2.85% have only depression, 1.97% have only anxiety disorders, and 0.98% have comorbid depression and anxiety. In multivariable multilevel logistic regression analysis sexually violated, having a chronic medical illness, being divorced and widowed, having a job, and being HIV positive were associated with depression and/or anxiety with a p-value of less than 0.05.</p><p><strong>Conclusions: </strong>According to the findings of this study the prevalence of depression and/or anxiety was 3.84%. This finding poses a significant challenge for the community to perform their daily tasks. As a result, the healthcare systems of Kenya have to mitigate the burden of depression and/or anxiety. All the clients must be treated since they received a diagnosis as reported by the physician.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0319571"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electric vehicle braking energy recovery control method integrating fuzzy control and improved firefly algorithm.","authors":"Jinfeng Xiong, Jingbin Song, Zhiqiang Zhang","doi":"10.1371/journal.pone.0320537","DOIUrl":"10.1371/journal.pone.0320537","url":null,"abstract":"<p><p>Braking energy recovery is crucial for improving the energy efficiency and extending the range of electric vehicles. If a large amount of braking energy is wasted, it will lead to problems such as reduced range and increased battery burden for electric vehicles. Therefore, an electric vehicle braking energy recovery control model that integrates fuzzy control algorithm with genetic firefly algorithm is proposed. Experimental analysis showed that the decrease in the state of charge of the model was 12.44%, and the braking energy recovery rate reached 52.1% in practical applications. Based on the above data, the proposed method can effectively control the amount of energy recovery. In addition, when the system chip value was 10%, the total amount of recovered energy at the battery end was the highest. Conversely, the total amount of recovered energy at the battery end was relatively small. In summary, the designed electric vehicle braking energy recovery control model can effectively control the amount of braking energy recovery of electric vehicles, ensuring the maximum recovery while also considering the durability and driving stability of the vehicle battery. The method can effectively extend mileage range in the electric vehicle industry, promoting the development and technological innovation of the new energy industry.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0320537"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associated factors, triggers and long-term outcome in Complex Regional Pain Syndrome (CRPS) in the upper limb - A descriptive cross-sectional study.","authors":"Astrid Parinder, Ellen Lyckegård Finn, Lars B Dahlin, Erika Nyman","doi":"10.1371/journal.pone.0320263","DOIUrl":"10.1371/journal.pone.0320263","url":null,"abstract":"<p><p>The pathophysiology behind Complex Regional Pain Syndrome (CRPS) is not fully understood and associated factors and triggers for developing the condition are debated. We aimed to study such factors and long-term outcome in a descriptive cross-sectional study with a well-defined population with CRPS in the upper limb and related to sex and CRPS type. In retrospectively collected data from medical records, 149 subjects [women n = 104 (70%); type 1 CRPS, n = 108 (72%); type 2 CRPS, n = 41 (28%); follow-up time 21 [8-43] months] were identified and analysed (Chi-squared test, Mann-Whitney U-test, and multiple linear regression). A majority were manual workers, and a larger proportion of subjects were smokers and had less post-secondary education than a reference population (p < 0.001 and p < 0.008). Men were younger, more frequently smoked, had higher BMI, and had lower education levels than women (p = 0.044, p = 0.007, p < 0.001, and p = 0.016, respectively). Subjects with CRPS type 2 were younger and had a longer time from symptoms until diagnosis, longer follow-up time, and more follow-up visits, indicating worse outcome (p = 0.016, p = 0.0012, p = 0.003, and p = 0.004, respectively). Among CRPS, 32% had a prior pain disorder and 7% had previously visited a pain management clinic. While there was no significant difference in mental illness occurrence before CRPS diagnosis compared to a reference population, mental illness increased by 76% after diagnosis. Factors such as CRPS type 2, older age, and delayed diagnosis were associated with longer follow-up periods. Additionally, 45% were on sick leave for over 12 months, and 20% were permanently unable to work. Socioeconomic deprivation is an associated factor in developing CRPS, in which a variety of triggers exist. Subjects with CRPS, particularly type 2, are at high risk of severe remaining symptoms, including mental illness and risk of never returning to work.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0320263"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Development and validation of a cardiovascular risk prediction model for Sri Lankans using machine learning.","authors":"Chamila Mettananda, Isuru Sanjeewa, Tinul Benthota Arachchi, Avishka Wijesooriya, Chiranjaya Chandrasena, Tolani Weerasinghe, Maheeka Solangaarachchige, Achila Ranasinghe, Isuru Elpitiya, Rashmi Sammandapperuma, Sujeewani Kurukulasooriya, Udaya Ranawaka, Arunasalam Pathmeswaran, Anuradhini Kasturiratne, Norihiro Kato, Rajitha Wickramasinghe, Prasanna Haddela, Janaka de Silva","doi":"10.1371/journal.pone.0321407","DOIUrl":"10.1371/journal.pone.0321407","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0309843.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0321407"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated analysis and single-cell sequencing of mitochondrial metabolism related gene molecular subtype and diagnostic model in ulcerative colitis.","authors":"Li Li, Xiaoyao Chen, Tao Li, Bing Sun, Bo Zhang, Weifeng Zhang, Junbo Wu, Meng Cui, Guoliang Wu","doi":"10.1371/journal.pone.0320010","DOIUrl":"10.1371/journal.pone.0320010","url":null,"abstract":"<p><p>Ulcerative colitis (UC) is a chronic inflammatory bowel disease that seriously affects the life expectancy of patients. Although increasingly sophisticated combinations of drugs can alleviate symptoms, 10-20% of patients still do not respond well. Therefore, it is necessary to further explore the pathogenesis and potential biomarkers of UC. Many clues have suggested the important value of mitochondrial metabolism in UC, but its role and related targets need to be further explored. By public database data, we identified differentially expressed mitochondrial metabolism related genes (MMRG) in UC. Subsequently, we identified biomarkers associated with MMRG based on a machine learning approach. After classifying the MMRG-associated molecular subtypes of UC, we comprehensively analyzed the MMRG biomarkers and the relationship between the MMRG molecular subtypes and immune infiltration characteristics. Single-cell sequencing analysis showed significant expression pattern of MMRG signatures in different cell subtypes. qRT-PCR and western blot further confirmed the abnormal expressions of selected genes in vitro. Our findings provided a new perspective on the role of MMRG in UC.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0320010"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delivering systems-level change to improve post-diagnostic dementia support: Qualitative findings from the PriDem study.","authors":"Emily Spencer, Katie Flanagan, Marie Poole, Federica D'Andrea, Maud Hevink, Jane Wilcock, Kate Walters, Louise Robinson, Greta Rait, Sarah Griffiths","doi":"10.1371/journal.pone.0317811","DOIUrl":"10.1371/journal.pone.0317811","url":null,"abstract":"<p><strong>Background: </strong>There are 900,000 people with dementia in England and Wales. Existing models of post-diagnostic support are unsustainable and unaffordable. The PriDem programme developed a new model of primary care-based dementia care, whereby a Clinical Dementia Lead (CDL) would facilitate systems-level change.</p><p><strong>Aim: </strong>To assess barriers and facilitators to implementation of the PriDem intervention.</p><p><strong>Methods: </strong>7 general practices participated in a qualitative process evaluation, as part of the mixed-methods feasibility and implementation study. Practices were located within 4 Primary Care Networks in the North East and South East of England. 26 healthcare professionals, 14 people with dementia and 16 carers linked to participating general practices participated in semi-structured individual and small group interviews. Additional qualitative data were generated through nonparticipant observations and researcher fieldnotes from CDL intervention supervision sessions. Data were analysed using abductive codebook thematic analysis informed by Normalisation Process Theory (NPT).</p><p><strong>Results: </strong>Six themes were generated: 1) The rocky ground of primary care; 2) The power of people; 3) Tension between adaptability and fidelity; 4) Challenging the status quo: reimagining care planning; 5) One size doesn't fit all; 6) Positive effects on people and systems: towards sustainability. Through the lens of NPT we can understand the contextual challenges facing primary care, the mechanisms (e.g., work undertaken by individuals) to overcome those challenges, as well as the potential outcomes of such an approach, in terms of longer-term sustainability of changes made.</p><p><strong>Conclusions: </strong>Despite the pressures facing primary care within England and Wales, meaningful change can be made to practice in the care of people with dementia. The presence of motivated and engaged staff are critical to implementation, as is ensuring understanding of complex interventions, so that fidelity can be maintained. People with dementia and carers benefitted from improved care systems. Commissioners should consider the benefits of a CDL-led approach.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0317811"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of chronic disease comorbidity patterns in middle-aged and elderly smokers in China: The China Health and Retirement Longitudinal Study.","authors":"Shanwen Sun, Yali Wang, Hailong Hou, Linlin Chen, Yuqi Niu, Yefan Shao, Xiaochun Zhang","doi":"10.1371/journal.pone.0319026","DOIUrl":"10.1371/journal.pone.0319026","url":null,"abstract":"<p><strong>Background: </strong>China has the largest tobacco consumer population in the world, and with the increasing severity of aging, the health issues caused by smoking continue to draw attention. This study aims to explore the current state of chronic disease comorbidity under different smoking patterns, providing a foundation for the formulation of public health policies.</p><p><strong>Methods: </strong>A total of 10771 participants older than 45 were included from CHARLS collected in 2020 after screening. The research variables were extracted and processed using Stata 18.0 software, followed by data filtering and organization in Excel. Through chi-square tests and multinomial logistic regression analysis, the study explored the influencing factors of comorbidity patterns under different smoking statuses.</p><p><strong>Results: </strong>The results indicate that within the framework of multiple chronic conditions, 2,254 individuals (20.9%) were relatively healthy, while 79.1% had one or more chronic conditions: 3,656 in the simple chronic disease group (33.9%), 3,998 in the minor complex chronic disease group (37.1%), and 863 in the major complex chronic disease group (8.0%). The severity of comorbidity patterns was significantly associated with age, alcohol consumption, hospitalization in the past year, outpatient visits in the past month, insufficient sleep, and poor cognitive function across different smoking statuses. Additionally, living in urban areas and having depression were linked to higher comorbidity severity among non-smokers. Among smokers, being female and having low life satisfaction were independent risk factors for comorbidity patterns. In the group of former smokers, intense physical activity was associated with an increased risk of severe comorbidity patterns.</p><p><strong>Conclusion: </strong>In response, it is recommended to strengthen public health strategies and interventions related to chronic disease comorbidity among smokers.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0319026"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gynecologic health of women with multiple sclerosis: An overview on the current status and findings of Pap tests in a low-income setting.","authors":"Masoud Etemadifar, Shima Shoeib, Mehri Salari, Mohammadreza Etemadifar, Nahad Sedaghat","doi":"10.1371/journal.pone.0320069","DOIUrl":"10.1371/journal.pone.0320069","url":null,"abstract":"<p><strong>Background: </strong>Women with MS (wwMS), particularly ones in low-income settings, and exposed to disease-modifying therapy (DMT), could have specific gynecological health-related issues.</p><p><strong>Aim: </strong>To assist policy making and lead further research by describing the current status of gynecological health and Pap test results in wwMS.</p><p><strong>Methods: </strong>Cross-sectional study on wwMS living in Isfahan, Iran. Participants were surveyed and referred for a Pap test, results of which were compared with 1:2 age- and socioeconomic status-matched healthy controls (HC). Primary outcome was the degree of non-benign squamous/glandular cell abnormalities. Secondary outcomes were presence of evidence of infection, and the degree of benign inflammatory/reactive changes. Logistic regression models were utilized for analyses.</p><p><strong>Results: </strong>197 wwMS were included (mean age [SD], 41.2 [8.3]; median EDSS (IQR) 1.5 [0.5]). 74.1% reported having sexual activity more than once per week in the past year. For contraception, 21.6% and 16.8% used calendar-based methods and male condoms, respectively. 7% had contracted a gynecological infection in the past. Only 1% had received HPV vaccination. Compared to HC, benign reactive/inflammatory changes in Pap tests were less frequently seen in the wwMS (OR: 0.3; 95% CI: 0.2, 0.4; p <  0.001), while evidence of infection was seen more frequently (OR: 11.5, 95% CI: 3.3, 40; p <  0.001). Results were consistent across DMT groups except anti-CD20 therapies. Additionally, the frequency of non-benign changes in wwMS was two times of that in the HC, but the study lacked adequate power to confirm statistical significance (1.5% vs. 0.8%, OR: 2; 95% CI: 0.4, 10.1; p =  0.39).</p><p><strong>Conclusion: </strong>There is room for improvement of the gynecological health status of wwMS who live in low-income settings. Also, findings support an immune dysfunction in the cervices of DMT-exposed wwMS. Additionally, further research is merited to determine the risk of changes of malignant potential in cervices of wwMS.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0320069"},"PeriodicalIF":2.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143736119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}