PLoS ONE最新文献

{"title":"High-density perimetry in the assessment of foveal avascular zone and macular structure in glaucoma.","authors":"Gustavo Coelho Caiado, Gustavo Albrecht Samico, Gilvan Vilarinho da Silva Filho, Sergio Henrique Teixeira, Tiago Santos Prata, Carolina Pelegrini Barbosa Gracitelli, Augusto Paranhos","doi":"10.1371/journal.pone.0333363","DOIUrl":"10.1371/journal.pone.0333363","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the association between foveal avascular zone (FAZ) parameters (area, perimeter and circularity) with macular high density perimetry (Octopus Macular program), macular vessel density (mVD) and ganglion cells layer thickness (GCLT) in glaucoma patients.</p><p><strong>Methods: </strong>This cross-sectional study included 89 eyes from 57 glaucoma patients. All participants underwent high-density perimetry (Octopus 900 Macular and G programs). FAZ metrics and mVD were obtained via Optical Coherence Tomography Angiography (OCTA) (Triton, Topcon), and GCLT was measured across global, superior, and inferior sectors. FAZ parameters were automatically extracted using ImageJ with axial length correction. Structure-structure and structure-function associations were assessed using mixed-effects linear regression models, adjusting for inter-eye correlation, age, and GCLT when appropriate.</p><p><strong>Results: </strong>Mean age was 66.67 ± 7.49 years old. FAZ area and perimeter were significantly associated with mean defect of macular program (mMD), central mVD, and GCLT (p < 0.05). FAZ area remained significantly associated with GCLT even after controlling for age (p < 0.05). FAZ perimeter and circularity were independently associated with age. FAZ perimeter and circularity were mainly age-related, while area was linked to glaucomatous damage. FAZ parameters were more strongly related to superior than inferior GCLT. Glaucoma severity was categorized using Brusini's Glaucoma Staging System. Higher mMD values were observed in more advanced stages of glaucoma.</p><p><strong>Conclusions: </strong>FAZ morphology reflects both glaucomatous damage and age-related vascular changes. By controlling for confounding variables, this study reinforces the role of FAZ metrics as complementary biomarkers for assessing structure-function relationships in glaucoma. High-density macular perimetry further improves spatial correspondence with anatomical alterations.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0333363"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prominent peaks and social discourses of the 2023 Escalation in the Ongoing Israel-Hamas armed conflict.","authors":"Reuben Ng, Ting Yu Joanne Chow","doi":"10.1371/journal.pone.0332746","DOIUrl":"10.1371/journal.pone.0332746","url":null,"abstract":"<p><strong>Background: </strong>This paper investigates the sharp increase in media posts and engagement surrounding the initial four months (October 2023-January 2024) of the Israel-Hamas armed conflict, following the inciting incident of a surprise militant attack launched on 7 October 2023. The impetus for documenting the trajectory of social media conversations lies in capturing and cataloging the biggest drivers of engagement, public sentiments and groundswell themes, reflecting the public zeitgeist during a period of uncertainty.</p><p><strong>Objectives: </strong>Few big data studies have delved into initial public discourse surrounding the escalation of the ongoing conflict. First, we identify the biggest generators of buzz, proxied by spikes in mention-counts; secondly, we identify content trends proxied by quantitative sentiment valence, top keywords and emojis, and qualitatively outline the biggest generators of media engagement via top engagement metrics (likes, reposts).</p><p><strong>Methods: </strong>We analyse a large corpus of publicly-available content from online platforms (Twitter, Reddit, Tiktok) obtained using academic-level API access, containing search terms: Palestine, Palestinian(s), Israel(i)(s), Gaza, Hamas. Our first research aim utilizes a prominent peaks model (upper-quartile significance threshold of prominence>1,500,000). Our second research aim utilized qualitative analysis on valence, top keywords and emojis, and top themes.</p><p><strong>Results: </strong>Eight prominent peaks were identified, finding that news about violence (e.g., airstrikes, citizen harm), groundswell movements (e.g., international activism like worldwide strikes, protests and marches, awareness movements, and outrage in response to current conditions) and politically-charged happenings (e.g., missile strikes) had the biggest hand in boosting discoursal spikes. Valence scores were generally negative, following a general monthly distribution of negative (59%), neutral (31%), and positive (10%), with main keywords focused on terror, violence, and calls for ceasefire. Qualitatively, we find salient groundswell movements (e.g., e-sims for Gaza, content creator strikes for Palestine, circulation of boycott consumer brand lists, co-option of the watermelon emoji as shorthand for support for the cause) and find that the online space is dominated by a fixation on celebrity opinions on the conflict and the circulation of gory footage.</p><p><strong>Conclusions: </strong>Overall, emergent public chatter worryingly peaks in response to incendiary news about violence, gory footage and celebrity opinions, though discoursal spikes are also slanted toward groundswell movements of goodwill.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0332746"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social media as societal microcosm: A decade of LGBT Twitter conversations in Singapore.","authors":"Reuben Ng, Ting Yu Joanne Chow, Wenshu Yang","doi":"10.1371/journal.pone.0332700","DOIUrl":"10.1371/journal.pone.0332700","url":null,"abstract":"<p><strong>Background: </strong>Singapore occupies a curious societal grey-area: a digitally savvy country with a colonial-remnant law against homosexuality (penal code 377A), widely acknowledged as non-proactively enforced, existing to placate a conservative society; hotly contested for years and finally repealed in Parliament in 2022. Within a national context of state-upheld heteronormativity, yet with homosexuality not entirely condemned, Singapore occupies a liminal space where subtle resistance is carefully negotiated, especially in online spaces.</p><p><strong>Objectives: </strong>This study investigated LGBT-adjacent discussions across social media over a decade (2011-2021) for salient topics, sentiment distribution, emotional intensity frames and nuanced topics.</p><p><strong>Methods: </strong>Historical Twitter data containing LGBT keywords (N = 15,659) were collected and analyzed using bi-term topic modelling, sentiment score modelling, and emotional intensity modelling. Qualitative thematic analysis was conducted on highest-scoring emotion tiers.</p><p><strong>Results: </strong>Sentiment was distributed over a range: Very Positive (6%), Positive (33%), Neutral (11%), Negative (42%), Very Negative (7%). Predominant emotions were Joy (39%), Anger (32%), Sadness (11%), Fear (11%). Of themes from highest-scoring emotional-intensity tweets, Anger included: 'gay' used derogatorily; heated debates over ideological-often religious-differences; dissent within the community, condemning exclusionary views. Fear and Sadness included distress over violence (mass shootings, harassment, bullying); lack of acceptance (criminalization, protests over local pride event 'Pinkdot'; lack of familial support). Joy stemmed from the celebration of pride month.</p><p><strong>Conclusions: </strong>Our findings highlight nuanced emotional intensities, profiles undertones of LGBT dissent and support, fractured along a schism of differing views and contrasting opinions-a societal microcosm of a divisive topic. Practically, this presents a decade-long barometer of dominant trigger points that may help facilitate conversations on the affective concerns of the local population.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0332700"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automation in microinjection for zebrafish pericardial space with image-based motion control and batch agarose microplate.","authors":"Hyuk-Jin Lee, Hyun-Kyu Lee, Sang-Won Lee, Ye-Won Son, Jun-Nyeong Shin, Sohee Kim","doi":"10.1371/journal.pone.0333369","DOIUrl":"10.1371/journal.pone.0333369","url":null,"abstract":"<p><p>Microinjection enables the precise delivery of substances into specific areas of small animals, such as zebrafish, whose xenograft models can be a promising platform for developing rapid and personalized cancer therapies. However, manual microinjection exhibits experimental variability and low reproducibility, as it relies on the expertise of researchers. To address these problems, automated microinjection systems have been developed in recent years. In this study, we propose a microrobotic system based on an image recognition AI model that extracts key feature points to define the pericardial space in zebrafish larvae at 2 days post-fertilization. Using the geometric relationships among feature points, the system optimizes the glass capillary insertion motion for precise microinjection. We also introduced a batch agarose microplate that prevents dehydration while stabilizing the larvae, which improved the survival rate compared to the conventional plate (log-rank test, p < 0.0001). The proposed automation system achieved success rates of 80.8% (n = 1129) for microinjection and a 92.1% (n = 1143) for survival. Moreover, we successfully injected colorectal cancer cell lines (HCT116 and SW620) into the pericardial space, resulting in an engraftment success rate of 96.2% (n = 610). Our system exhibits higher success rates and reproducibility compared to manual microinjection, allowing even inexperienced researchers to perform stable injections. These results demonstrate that our system effectively enhances the efficiency and reproducibility of experiments involving zebrafish-based cancer research and xenograft model generation.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0333369"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FAR-AM: A hybrid attention framework for fire cause classification.","authors":"Heng Peng, Kun Zhu","doi":"10.1371/journal.pone.0333131","DOIUrl":"10.1371/journal.pone.0333131","url":null,"abstract":"<p><p>Automated cause classification of fire accident reports (FIREAR) is crucial for enhancing public safety and developing data-driven prevention strategies. However, existing deep learning models often struggle with the unique challenges these documents present-namely their extreme length, high semantic noise, and fragmented causal information. To overcome these limitations, we propose the Fire Accident Reports Attention Mechanism (FAR-AM), a novel hybrid deep learning framework. FAR-AM first uses a large language model (LLM) to preprocess lengthy raw reports into concise, high-signal summaries. Its core architecture then employs an inter-layer self-attention mechanism to dynamically fuse hierarchical features across all encoder layers of BERT. The fused features are subsequently processed by a TextCNN for final classification. We evaluate FAR-AM on AGNews(title), AGNews(content), THUCNews, and our real-world FIREAR corpus. FAR-AM outperforms strong transformer baselines, including RoBERTa. On the FIREAR dataset, it achieves 73.58% accuracy and 70.65% F1. A comprehensive ablation study further validates the contribution of each component in the multi-stage framework. These results indicate that, for complex domain-specific tasks, specialized hybrid architectures can be more effective and robust than monolithic, general-purpose models.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0333131"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the impact of antibody-dependent cellular phagocytosis-related genes on the prognosis of metastatic melanoma.","authors":"Junhao Chen, Jiapeng He, Xiaolong Xu, Haiyan Sun, Jianglin Zhang","doi":"10.1371/journal.pone.0333916","DOIUrl":"10.1371/journal.pone.0333916","url":null,"abstract":"<p><strong>Background: </strong>Metastatic melanoma is a challenging clinical condition with poor prognosis. Recent research has highlighted the role of antibody-dependent cellular phagocytosis (ADCP) in tumor immunity, suggesting prognostic implications for ADCP-related genes (ARGs). This study develops a prognostic model for metastatic melanoma using ARGs to enhance clinical decision-making and therapeutic strategies.</p><p><strong>Methods: </strong>Prognostic ARGs were identified from the GSE46517 and GSE7553 datasets. A prognostic model was constructed using LASSO-Cox regression and validated across multiple cohorts, including TCGA and GEO datasets. A nomogram was developed to assess survival outcomes in metastatic melanoma patients. Functional assays, including siRNA knockdown of DOCK10 in A375 cells, were conducted to validate the role of DOCK10 in melanoma progression.</p><p><strong>Results: </strong>A prognostic model based on six ARGs-NDRG1, HRAS, KPNA2, ICAM1, DOCK10, and CDC20-was developed. Patients were stratified into high- and low-risk groups based on risk scores, with high-risk patients showing poorer overall survival (OS) in both validation cohorts. The model was validated as an independent prognostic factor. Gene set enrichment analysis (GSEA) indicated that the low-risk group was enriched in immune-related pathways. High-risk patients exhibited higher genomic instability, which was associated with poorer prognosis. Knockdown of DOCK10 in A375 cells significantly reduced proliferation, migration, and invasion, confirming its role in melanoma progression.</p><p><strong>Conclusion: </strong>The model also demonstrated associations with immune cell infiltration and drug sensitivity, highlighting its potential utility in optimizing immunotherapy and chemotherapy strategies. This study developed a novel ARG-based prognostic model that aids in survival prediction and therapeutic decision-making for metastatic melanoma patients. DOCK10 was identified as a potential therapeutic target in melanoma metastasis.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0333916"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Parental involvement in school-based mental health interventions for young people in low-resource settings: A qualitative study from Zimbabwe and Ghana.","authors":"Rufaro Hamish Mushonga, Rebecca Jopling, Franklin Glozah, Tiny Kamvura, Suzanne Dodd, Denford Gudyanga, Arnold Maramba, Edith Dambayi, Christopher Abio Ayuure, Tarisai Bere, Fabian Sebastian Achana, Lucy Owusu, Dixon Chibanda, Melanie Abas, Benedict Weobong, Moses Kumwenda","doi":"10.1371/journal.pone.0334227","DOIUrl":"10.1371/journal.pone.0334227","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0322954.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0334227"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Filter bank common spatial pattern and envelope-based features in multimodal EEG-fTCD brain-computer interfaces.","authors":"","doi":"10.1371/journal.pone.0334075","DOIUrl":"10.1371/journal.pone.0334075","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0311075.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0334075"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Area of center of pressure in closed eye setting as a measure of postural sway: Association with frailty and functional capacity in older adults with diabetes.","authors":"Remi Kodera, Yoshiaki Tamura, Yuji Murao, Fumino Yorikawa, Ai Iizuka, Kazuhito Oba, Kenji Toyoshima, Yuko Chiba, Joji Ishikawa, Atsushi Araki","doi":"10.1371/journal.pone.0333608","DOIUrl":"10.1371/journal.pone.0333608","url":null,"abstract":"<p><p>Older adults with diabetes mellitus are at a higher risk of frailty, which can lead to disability and death; therefore, effective frailty screening is necessary in such populations. However, evidence linking sway meter indices to frailty or functional capacity remains limited. This cross-sectional study aimed to investigate the association of postural stability, assessed using a sway meter, with frailty and functional capacity in older patients with and without diabetes. Data from 362 older outpatients (149 with diabetes and 213 without) who visited the Frailty Clinic between 2021 and 2022 were analyzed. The Kihon Check List was used to define frailty and the Short Physical Performance Battery to assess functional capacity. The sway meter indices included locus length (Lo) and area of the center of pressure (Ao) with open eyes, locus length (Lc) and area of center of pressure (Ac) with closed eyes, and the Romberg ratio (Ac/Ao). Univariate and multivariate analyses were performed to determine associations. All sway meter indices were higher in patients with diabetes. In this group, Lo, Ao, and Ac levels were significantly higher in those with frailty, while Lo, Lc, Ao, and Ac levels were higher in those with low functional capacity. Receiver operating characteristic analyses showed that Ao and Ac had relatively high area under the curve for both diagnoses. Binominal logistic regression analyses revealed that Ac was significantly associated with frailty in patients with diabetes after adjusting for age, sex, HbA1c, cognitive function, number of medications, and several diabetic complication indices, including loss of Achilles tendon reflexes (odds ratio, 1.107; 95% confidence interval, 1.001-1.225; p = 0.048). Ac was also significantly associated with low functional capacity. These findings suggest that the area of the center of pressure, especially in a closed-eye setting, is associated with frailty and functional capacity in older adults with diabetes.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0333608"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accidental hypothermia in emergency care: multifactorial triage-based prediction of early critical outcomes in a temperate-climate cohort.","authors":"Kornél Ádám, Anna Stelkovics, Barbara Zadravecz-Heider, Dóra Melicher, Zsolt Bognár, Barbara V Farkas, Bánk G Fenyves, Szabolcs Gaál-Marschal, Csaba Varga","doi":"10.1371/journal.pone.0334328","DOIUrl":"10.1371/journal.pone.0334328","url":null,"abstract":"<p><strong>Background: </strong>Accidental hypothermia, defined by a core temperature <35 °C destabilizes metabolism, ventilation, and circulation, precipitating malignant arrhythmias or cardiac arrest. We characterized such patients in a Hungarian emergency department and sought early predictors of death or intensive care requirement.</p><p><strong>Methods: </strong>In this retrospective cohort (2020-2024) at Semmelweis University, adults with measured tympanic temperature <35 °C were identified. Demographics and Hungarian Emergency Triage System categories were recorded. Severity was graded based on the thresholds of Swiss staging and the Wilderness Medical Society classification. The primary outcome was emergency department death or admission to the intensive care unit. Prognostic performance of triage category, admission temperature, hypothermia severity thresholds, and combined models was assessed with receiver-operating-characteristic analysis. Odds ratios were derived from logistic regression, and separate receiver-operating-characteristic curves were generated for each predictor.</p><p><strong>Results: </strong>A total of 131 patients met the inclusion criteria. Median age was 67.0 years (IQR 59.0-75.0); 88 (67.2%) were male. Median admission temperature was 29.3 °C (IQR 26.1-31.4 °C); 47 (35.9%) had severe hypothermia (<28 °C). Median emergency department length of stay was 13.7 h (IQR 9.5-18.9 h). Sixteen patients (12.2%) required intensive care and 28 (21.4%) died before transfer, yielding a 33.6% critical‑outcome rate (44/131). Incidence tracked seasonal ambient temperatures, yet environmental temperature itself was not associated with the composite outcome. Triage category predicted critical outcome better than thresholds of either hypothermia-specific scale (AUC 0.683). Adding admission temperature improved accuracy (AUC 0.740, 95% CI 0.644-0.829).</p><p><strong>Conclusions: </strong>Despite milder winters, accidental hypothermia still carries substantial early mortality. Integrating admission temperature into a general triage system enhances prognostication and may guide rapid escalation of care. Our findings suggest the need for systematic surveillance, focused clinician education, and targeted resources to protect vulnerable patients in increasingly variable climates.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0334328"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}