PLoS ONE最新文献

{"title":"Retraction: Research on multi-objective optimal scheduling considering the balance of labor workload distribution.","authors":"","doi":"10.1371/journal.pone.0319636","DOIUrl":"10.1371/journal.pone.0319636","url":null,"abstract":"","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0319636"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human placental mesenchymal stem cells ameliorates premature ovarian insufficiency via modulating gut microbiota and suppressing the inflammation in rats.","authors":"Shudan Liu, Ting Wang, Yuanyuan Liu, Yiwei Li, Junbai Ma, Qikuan Hu, Hao Wang, Xiaoxia Zhang","doi":"10.1371/journal.pone.0313763","DOIUrl":"10.1371/journal.pone.0313763","url":null,"abstract":"<p><p>The core objective of this study was to explore the effects and potential mechanism of human placental mesenchymal stem cells (PMSCs) in improving early-onset ovarian dysfunction (POI). Mesenchymal stem cells with multidirectional differentiation ability were isolated from human placenta tissue and a culture system of human PMSCs was constructed for this study. Subsequently, we successfully constructed POI rat models using cisplatin induction. We randomly divided these models into four groups: CON group (blank control), MOD group (POI model), MED group (hormone therapy), and PMSC group (PMSCs therapy). Then, we compared the differences in estrus cycle, ovarian index, ovarian weight, and ovarian histopathological features, as well as hormones and inflammatory factors in rats of diverse groups. The content of lipopolysaccharide (LPS) in plasma was determined by limulus reagent kit. 16S rDNA sequencing was used to evaluate the changes in gut flora composition. Further, we investigated short-chain fatty acids (SCFAs) in the metabolites of rat gut microbiota by gas chromatography-mass spectrometry (GC-MS). As a result, we successfully established an efficient cell culture system of human placental mesenchymal stem cells (PMSCs) in vitro. Then, we evaluated the effects of PMSC intervention on POI rats: Compared to the untreated MOD group, the estrous cycle of rats in the PMSC group gradually became regular, the ovarian weight and ovarian index were significantly increased, and the ovarian tissue structure was improved by showing an increase in the number of follicles and a decrease in the number of atretic follicles. Moreover, PMSC intervention significantly affected plasma sex hormones by a major impact on follicle stimulating hormone (FSH) and Estradiol (E2). In terms of inflammatory factors, PMSC intervention decreased the levels of proinflammatory cytokines including interleukin (IL)-1β, IL-33, IL-6, and tumor necrosis factor (TNF)-α in plasma and ovarian tissue of POI rats. Meanwhile, the expression of anti-inflammatory cytokine IL-10 was increased. In addition, we found that there was ectopic lipopolysaccharide (LPS) in the blood of POI rats, which could be significantly reduced by PMSC intervention. Intestinal microbiota sequencing and analysis showed that after PMSC intervention, the phyla abundances of Firmicutes, Bacteroides, and Proteobacteria showed remarkable differences between the MOD and PMSC groups (P < 0.05). Further genus analysis showed that PMSC treatment had a major influence in gut microbitoa by increasing the abundances of Turicibacter and Desulfovibrio, as well as reducing Alloprevotella, Parabacteroides, Rikenellaceae_RC9_gut_group, and Rikenella. The changes of SCFAs in intestinal microbial metabolites of rats after PMSC intervention were analyzed: caproic acid level was markedly increased, butyric acid showed a decreased trend. Notably, we found a closed and complicated potential correlation among differential microbio","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0313763"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the risks: Stakeholder views on risk-based cervical cancer screening.","authors":"Maali-Liina Remmel, Kadri Suija, Anna Markina, Anna Tisler, Anda Ķīvīte-Urtāne, Mindaugas Stankūnas, Mari Nygård, Gunvor Aasbø, Laura Maļina, Anneli Uusküla","doi":"10.1371/journal.pone.0317986","DOIUrl":"10.1371/journal.pone.0317986","url":null,"abstract":"<p><strong>Background: </strong>The development of risk-based cancer screening programs requires a paradigm shift in existing practices and healthcare policies. Therefore, it is crucial to not only assess the effectiveness of new technologies and risk prediction models but also to analyze the acceptability of such programs among healthcare stakeholders. This study aims to assess the acceptability of risk-based cervical cancer screening (RB CCS) in Estonia from the perspectives of relevant stakeholders.</p><p><strong>Methods and materials: </strong>This qualitative study employed semi-structured interviews with healthcare policy and service level stakeholders in Estonia. The Theoretical Framework of Acceptability guided the interview design, and the findings were charted using framework analysis based on the Consolidated Framework for Implementation Research.</p><p><strong>Results: </strong>17 interviews were conducted with stakeholders, including healthcare professionals, cancer registry representatives, technology specialists, policymakers, and health insurance providers. While stakeholders generally supported the concept and potential benefits of RB CCS, recognizing its capacity to improve screening outcomes and resource allocation, they raised significant concerns about feasibility, complexity, and ethical challenges. Doubts were expressed about the readiness of the healthcare system and population, particularly the current health information system's capacity to support risk-based approaches. The need for evidence-based and internationally validated screening models, comprehensive public communication, provider training, and collaborative discussions involving all relevant parties, including the public, was emphasized.</p><p><strong>Conclusion: </strong>The favorable attitude towards RB CCS among stakeholders provides a strong foundation for advancing its development. However, a comprehensive strategy emphasizing the generation of robust evidence, strengthening healthcare infrastructure, prioritizing patient empowerment, and cultivating a collaborative environment built on trust is crucial.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0317986"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Distribution characteristics of insect diversity in long-term fixed monitoring plots in Northeast China.","authors":"","doi":"10.1371/journal.pone.0319600","DOIUrl":"10.1371/journal.pone.0319600","url":null,"abstract":"","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0319600"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Citation penalties following sexual versus scientific misconduct allegations.","authors":"Giulia Maimone, Gil Appel, Craig R M McKenzie, Ayelet Gneezy","doi":"10.1371/journal.pone.0317736","DOIUrl":"10.1371/journal.pone.0317736","url":null,"abstract":"<p><strong>Background and aim: </strong>Citations in academia have long been regarded as a fundamental means of acknowledging the contribution of past work and promoting scientific advancement. The aim of this paper was to investigate the impact that misconduct allegations made against scholars have on the citations of their work, comparing allegations of sexual misconduct (unrelated to the research merit) and allegations of scientific misconduct (directly related to the research merit).</p><p><strong>Methods: </strong>We collected citation data from the Web of Science (WoS) in 2021, encompassing 31,941 publications from 172 accused and control scholars across 18 disciplines. We also conducted two studies: one on non-academics (N = 231) and one on academics (N = 240).</p><p><strong>Results: </strong>The WoS data shows that scholars accused of sexual misconduct incur a significant citation decrease in the three years after the accusations become public, while we do not detect a significant citation decrease for scholars accused of scientific misconduct. The study involving non-academics suggests that individuals are more averse to sexual than to scientific misconduct. Finally, contrary to the WoS data findings, a sample of academics indicates they are more likely to cite scholars accused of sexual misconduct than those accused of scientific misconduct.</p><p><strong>Conclusions: </strong>In the first three years after accusations became public, scholars accused of sexual misconduct incur a larger citation penalty than scholars accused of scientific misconduct. However, when asked to predict their citing behavior, scholars indicated the reverse pattern, suggesting they might mis-predict their behavior or be reluctant to disclose their preferences.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0317736"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Does chubby Can get lower grades than skinny Sophie? Using an intersectional approach to uncover grading bias in German secondary schools.","authors":"","doi":"10.1371/journal.pone.0320170","DOIUrl":"10.1371/journal.pone.0320170","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0305703.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0320170"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracellular accumulation of free cholesterol in macrophages triggers a PARP1 response to DNA damage and PARP1 impairs lipopolysaccharide-induced inflammatory response.","authors":"Kenneth K Y Ting, Hisham M Ibrahim, Nitya Gulati, Yufeng Wang, Jonathan V Rocheleau, Myron I Cybulsky","doi":"10.1371/journal.pone.0318267","DOIUrl":"10.1371/journal.pone.0318267","url":null,"abstract":"<p><p>The formation of macrophage (Mφ) foam cells is a hallmark of atherosclerosis, yet how the process of lipid loading can modulate Mφ inflammatory responses by rewiring their intracellular metabolic circuits is not well understood. Our previous studies have shown that the accumulation of oxidized LDL (oxLDL) or free cholesterol in Mφs impaired their inflammatory response by suppressing HIF-1α-mediated glycolysis and upregulating NRF2 antioxidative response. However, it remains unclear if other metabolic processes are also contributory. In this study, we found that the accumulation of free cholesterol, but not oxLDL, in primary murine thioglycolate-elicited peritoneal Mφs (PMφs) enhanced a PARP1-dependent response associated with repair of DNA damage, which was characterized by poly ADP-ribosylation of proteins, phosphorylation of histone 2A.X and consumption of NAD + . Both oxLDL and cholesterol enhanced the PARP1 response after LPS stimulation. Treatment of PMφs with mitoTEMPO, a specific mitochondrial reactive oxygen species (mtROS) scavenger, alleviated mtROS during cholesterol loading, blocked the PARP1 response and partially restored LPS- induced inflammatory gene expression. In contrast to inhibition of PARP1 enzymatic activity, knockdown of PARP1 expression in RAW264.7 Mφs with siRNA elevated LPS-induced inflammatory gene expression. Overall, our study suggests that cholesterol accumulation triggers a PARP1 response to DNA damage in Mφs and that PARP1 inhibits LPS-mediated inflammation through a non-enzymatic function.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0318267"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lung cancer screening with volume computed tomography is cost-effective in Greece.","authors":"Xuanqi Pan, Katerina Togka, Hilde Ten Berge, Lisa de Jong, Harry Groen, Maarten J Postma, Eleftherios Zervas, Ioannis Gkiozos, Christoforos Foroulis, Kyriaki Tavernaraki, Sofia Lampaki, Georgia Kourlaba, Antonios Moraris, Sofia Agelaki, Konstantinos Syrigos","doi":"10.1371/journal.pone.0316351","DOIUrl":"10.1371/journal.pone.0316351","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the cost-effectiveness of lung cancer screening (LCS) employing volume-based low-dose computed tomography (LDCT) in contrast to the absence of screening, targeting an asymptomatic high-risk population in Greece, leveraging the outcomes derived from the NELSON study, the largest European randomized control trial dedicated to LCS.</p><p><strong>Methods: </strong>A validated model incorporating a decision tree and an integrated state-transition Markov model was used to simulate the identification, diagnosis, and treatments for a population at high risk of developing lung cancer, from a healthcare payer perspective. Screen-detected lung cancers, costs, life years (LYs), quality-adjusted life years (QALYs), and the incremental cost-effectiveness ratio (ICER) were predicted. Sensitivity and scenario analyses were conducted to assess the robustness and reliability of the model's outcomes under varying parameters and hypothetical situations.</p><p><strong>Results: </strong>Annual LCS with volume-based LDCT detected 17,104 more lung cancer patients at early-stage among 207,885 screening population, leading to 8,761 premature lung cancer deaths averted. In addition, in contrast to no screening, LCS yielded 86,207 LYs gained and 50,207 incremental QALYs at an additional cost of €278,971,940, resulting in an ICER of €3,236 per LY and €5,505 per QALY, over a lifetime horizon. These estimates were robust in sensitivity analyses.</p><p><strong>Conclusions: </strong>LCS with volume-based LDCT, targeting an asymptomatic high-risk population, is highly cost-effective in Greece. Implementing LCS ensures efficient allocation of public healthcare resources while delivering substantial clinical benefits to lung cancer patients.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0316351"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling image construction by modality: Corpus-based diachronic insights into the reports to the Party Congress of China.","authors":"Jiannan Song, Dengcheng Li","doi":"10.1371/journal.pone.0316017","DOIUrl":"10.1371/journal.pone.0316017","url":null,"abstract":"<p><p>Recent years have witnessed a \"discursive turn\" in image construction studies. This article explores the linguistic features of image construction. We provide a corpus-based diachronic study of the distribution of modality in The Reports to the 16th to 20th National Congress of the Communist Party of China and unravel the role of the modal verbs in conceptualizing China's images in The Reports. To analyze the national image, we need to understand how the various elements in The Reports, i.e., actors, actions, and situations, are not only depicted but also intricately interconnected in terms of volition, obligation, and prediction. The diverse national image profiles can be discerned through the lens of how the actors perceive the situations in relation to what is deemed desirable, committed, possible, important, and expected in the context of The Reports. The study finds that The Reports, based on the frequency, value, category and translation of the modal verbs, can project different image profiles of the nation, such as a reliable planner, a committed and powerful leader, and an active participant showing respect for others.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0316017"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Utility analysis and demonstration of real-world clinical texts: A case study on Japanese cancer-related EHRs.","authors":"Shuntaro Yada, Tomohiro Nishiyama, Shoko Wakamiya, Yoshimasa Kawazoe, Shungo Imai, Satoko Hori, Eiji Aramaki","doi":"10.1371/journal.pone.0320522","DOIUrl":"10.1371/journal.pone.0320522","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0310432.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0320522"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}