PLoS ONE最新文献

{"title":"Short sleep duration is a significant risk factor of obesity: A multicenter observational study of healthy adults in Japan.","authors":"Mami Takahashi, Takeshi Shimamoto, Lumine Matsumoto, Yusuke Mitsui, Yukari Masuda, Hirotaka Matsuzaki, Eriko Hasumi, Chie Bujo, Keiko Niimi, Takako Nishikawa, Ryoichi Wada, Nobutake Yamamichi","doi":"10.1371/journal.pone.0319085","DOIUrl":"10.1371/journal.pone.0319085","url":null,"abstract":"<p><p>This multicenter study aimed to elucidate the association between sleep duration and various lifestyle-related disorders in healthy adults in Japan. A total of 62,056 healthy participants (age: 49.4 ±  10.9 years) who received medical checkups from 2010 to 2020 were analyzed cross-sectionally and longitudinally. The mean sleep duration was 6.2 ±  1.0 h in men and 6.1 ±  1.0 h in women. The distribution of sleep duration showed that older people tended to sleep longer, which was clearly observed in men but not in women. Univariate analyses showed that older age, lower body mass index (BMI), habitual drinking, and habitual exercise were significantly associated with longer sleep duration. Multivariate analyses in men showed that sleep duration was positively associated with age, habitual exercise, serum triglyceride (TG), systolic blood pressure (SBP), and habitual drinking and negatively associated with BMI and hemoglobin A1c (HbA1c). Alternatively, in women, sleep duration was positively associated with habitual exercise and TG and negatively associated with BMI, high-density lipoprotein-cholesterol, HbA1c, and current smoking. During the follow-up period, 3,360 of 31,004 individuals (10.8%) developed obesity. The Cox proportional hazards model showed that shorter sleep duration was a significantly higher risk of obesity, and longer sleep duration might be a lower risk of obesity. On the other hand, 1,732 of 39,048 participants (4.4%) developed impaired glucose tolerance, and 6,405 of 33,537 participants (19.1%) developed hypertriglyceridemia. However, the Cox proportional hazards model did not show significant association between sleep duration and impaired glucose tolerance or hypertriglyceridemia. In conclusion, our large-scale cross-sectional study showed that sleep duration was positively associated with habitual exercise and TG and negatively associated with BMI and HbA1c, regardless of sex. Longitudinal analysis revealed that shorter sleep duration is a significant risk factor for obesity.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0319085"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimum dietary diversity and its determinants among lactating mothers in five Sub-Saharan African countries: A multilevel analysis.","authors":"Alebachew Ferede Zegeye, Tadesse Tarik Tamir, Desale Bihonegn Asmamaw, Desalegn Anmut Bitew, Elsa Awoke Fentie, Bewuketu Terefe, Rahel Mulatie Anteneh, Lemlem Daniel Baffa, Misganaw Guadie Tiruneh, Kaleb Assegid Demissie, Tadele Biresaw Belachew, Wubshet D Negash, Melak Jejaw","doi":"10.1371/journal.pone.0308590","DOIUrl":"10.1371/journal.pone.0308590","url":null,"abstract":"<p><strong>Background: </strong>Ensuring minimum dietary diversity is crucial for lactating mothers. It allows them to consume a variety of foods from different groups, meeting their nutritional needs and supporting maternal and infant health. Despite the global impact of undernutrition and micronutrient deficiencies, the prevalence and determinants of minimum dietary diversity during lactation remain poorly recognized in developing countries. This research aims to assess minimum dietary diversity and its determinants among lactating mothers in five Sub-Saharan African countries.</p><p><strong>Methods: </strong>Data from the most recent Demographic and Health Surveys, which covered five Sub-Saharan African countries between 2021 and 2023, were used to execute secondary data analysis. This study included 19,917 lactating mothers in total. Using a multilevel mixed-effects logistic regression model, the variables associated to the minimum dietary diversity were established. Significant factors associated with the minimum dietary diversity were found at p-values < 0.05. The adjusted odds ratio and 95% CI were used to interpret the result. The model with the highest loglikelihood ratio and lowest deviance was declared to be the best fit.</p><p><strong>Results: </strong>The magnitude of minimum dietary diversity among lactating mothers in Burkina Faso, Ghana, Kenya, Mozambique, and Tanzania was 25.66% (95% CI: 24.47, 25.75). Factors such as secondary and above educational level (AOR =  1.38, 95% CI: 1.18, 1.61), employed mothers (AOR =  1.40, 95% CI: 1.26, 1.56), distance which was not a big problem to access health facilities (AOR =  1.35, 95% CI: 1.21, 1.51), health facility delivery (AOR =  1.25, 95% CI: 1.08, 1.45), rich wealth status (AOR =  1.86, 95% CI: 1.60, 2.17), high community ANC utilization (AOR =  1.18, 95% CI: 1.04, 1.35), and reside in Ghana (AOR =  4.21, 95% CI: 3.60, 4.94) had higher odds of minimum dietary diversity.</p><p><strong>Conclusions: </strong>This study reveals that lactating mothers have low dietary diversity. Both community-level and individual-level factors impact this diversity. Consequently, health ministries in Burkina Faso, Kenya, Ghana, Mozambique, and Tanzania should prioritize women who underutilize antenatal services and those without formal education when designing strategies and policies.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0308590"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: Chemical characteristics of groundwater and source identification in a coastal city.","authors":"","doi":"10.1371/journal.pone.0319598","DOIUrl":"10.1371/journal.pone.0319598","url":null,"abstract":"","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0319598"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A guide, cornerstone, and appetizer: An elicited metaphor analysis of Chinese university students' perceptions of English language textbooks.","authors":"Molly Xie Pan, Wei Lin","doi":"10.1371/journal.pone.0315292","DOIUrl":"10.1371/journal.pone.0315292","url":null,"abstract":"<p><p>Existing research on EFL learners' attitudes towards English language textbooks primarily investigates metaphors at the level of mental spaces, limiting insights into embodied cognition and experience. This study extends the analysis of metaphors to a more schematic level of domains/frames. We analyzed 163 metaphors from 123 Chinese university students' perceptions of English language textbooks under the guidance of Conceptual Metaphor Theory and the meta-functions of metaphors in language education. Findings reveal textbooks' three primary roles in learning English as i) a guide in a journey, ii) a cornerstone of a building, and iii) an appetizer in eating. The Chi-Square Test of Independence showed a moderate association between metaphor sources and emotional valence, with nature and container metaphors associated with negative evaluations. The combination of discourse analysis and statistical analysis highlights learners' physical and emotional engagement with English language textbooks. Pedagogical implications are discussed.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0315292"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mis-splicing drives loss of function of p53E224D point mutation.","authors":"Ian C Lock, Nathan H Leisenring, Warren Floyd, Eric S Xu, Lixia Luo, Yan Ma, Erin C Mansell, Diana M Cardona, Chang-Lung Lee, David G Kirsch","doi":"10.1371/journal.pone.0318856","DOIUrl":"10.1371/journal.pone.0318856","url":null,"abstract":"<p><strong>Background: </strong>The tumor suppressor p53 (Trp53), also known as p53, is the most commonly mutated gene in cancer. Canonical p53 DNA damage response pathways are well characterized and classically thought to underlie the tumor suppressive effect of p53. Challenging this dogma, mouse models have revealed that p53-driven apoptosis and cell cycle arrest are dispensable for tumor suppression. Here, we investigated the inverse context of a p53 mutation predicted to drive the expression of canonical targets but is detected in human cancer.</p><p><strong>Methods: </strong>We established a novel mouse model with a single base pair mutation (GAG>GAT, p53E221D) in the DNA-Binding domain that has wild-type function in screening assays, but is paradoxically found in human cancer in Li-Fraumeni syndrome. Using mouse p53E221D and the analogous human p53E224D mutants, we evaluated expression, transcriptional activation, and tumor suppression in vitro and in vivo.</p><p><strong>Results: </strong>Expression of human p53E224D from cDNA translated to a fully functional p53 protein. However, p53E221D/E221D RNA transcribed from the endogenous locus is mis-spliced resulting in nonsense-mediated decay. Moreover, fibroblasts derived from p53E221D/E221D mice do not express a detectable protein product. Mice homozygous for p53E221D exhibited increased tumor penetrance and decreased life expectancy compared to p53WT/WT animals.</p><p><strong>Conclusions: </strong>Mouse p53E221D and human p53E224D mutations lead to splice variation and a biologically relevant p53 loss of function in vitro and in vivo.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0318856"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Yangling inclined trellis tree shape on light interception efficiency, fruit quality, and yield of sweet cherry cv: 'Jimei'.","authors":"Juan Zhang, Wei Xu, Zhiqiang Dou, Liuyi Pan, Tian Wan, Feng An, Zhifang Yang, Yuliang Cai","doi":"10.1371/journal.pone.0317101","DOIUrl":"10.1371/journal.pone.0317101","url":null,"abstract":"<p><p>Different tree shapes (TSs) directly influence canopy structure, light interception, and photosynthetic activity, impacting fruit quality and yield. This study investigated the effects of light interception efficiency (LIE) on the quality and yield of \"Jimei\" sweet cherry fruits by comparing two tree shapes: the Yangling inclined trellis arm TS (YLL-TS) and the Super slender spindle TS (SSS-TS). Using three-dimensional digitization techniques, we analyzed the growth relationships between branches and leaves, constructed virtual canopy models, and examined branch composition, leaf area, and spatial distribution. The present study indicated varying correlation coefficients for growth relationships between branches and leaves in the two TSs. For YLL-TS, the smallest correlation coefficient was between the length of nutrient-bearing branches and leaf petiole length (r² =  0.206), while the largest was between the length of short fruit-bearing branches and the number of branches and leaves (r² =  0.851). For SSS-TS, the smallest was between the length of medium fruit-bearing branches and leaf petiole length (r² =  0.211), and the largest was between the length of nutrient-bearing branches and leaf area (r² =  0.827). The LIE for YLL-TS (0.53 STAR value) was significantly higher than SSS-TS (0.20 STAR value). Although YLL-TS had fewer branches and leaf area, it showed increases in LIE by 48%, 42%, and 27% for overall canopy, fruit-bearing branches, and nutrient-bearing branches, respectively. The photosynthetic parameters (Pn, Tr, Gs, and Ci) were higher in SSS-TS. YLL-TS exhibited a higher economic yield (4.075 kg/ m2) and is more suitable for dense planting, facilitating widespread cultivation.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0317101"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the placement of gambling problems within the Hierarchical Taxonomy of Psychopathology.","authors":"Carla Martí Valls, Anders Håkansson, Matti Cervin","doi":"10.1371/journal.pone.0313532","DOIUrl":"10.1371/journal.pone.0313532","url":null,"abstract":"<p><p>The placement of gambling problems within the Hierarchical Taxonomy of Psychopathology (HiTOP) framework, which organizes psychopathology alongside broad overarching symptom spectra, is unclear. With the objective to identify associations between gambling problems and the internalizing, externalizing, and thought disorder spectra of the HiTOP, we distributed an online survey to a sample of 1005 Swedish gamblers (52.4% men, aged 18 to 60 and older). Gambling problems were measured using the Problem Gambling Severity Index, and the main HiTOP spectra were assessed with brief versions of the Inventory of Depression and Anxiety Symptoms II, the Externalizing Spectrum Inventory, and the Thought Disorder Scale. Exploratory and confirmatory factor analysis showed that the brief HiTOP scales adequately captured the internalizing, externalizing, and thought disorder spectra. Within this structure, gambling problems emerged as a distinct factor significantly correlated with all three spectra and with unique associations with each: externalizing (β =  0.33, p < .001), thought disorder (β =  0.30, p = .001) and internalizing (β =  0.22, p = .022). In men, gambling problems were significantly associated with the thought disorder (β =  0.54, p < .001) and externalizing (β =  0.31, p < .001) spectra. In women, gambling problems were significantly associated with the externalizing (β =  0.39, p < .001) and internalizing (β =  0.35, p = .013) spectra. Our study is a first attempt to link gambling problems to the three main spectra of the HiTOP. Our findings show that gambling problems are associated with all three spectra and that there may be potential gender differences in the associations between gambling problems and co-occurring psychopathology.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0313532"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analyses of chloroplast genomes of Theobroma cacao from northern Peru.","authors":"Daniel Tineo, Danilo E Bustamante, Martha S Calderon, Manuel Oliva","doi":"10.1371/journal.pone.0316148","DOIUrl":"10.1371/journal.pone.0316148","url":null,"abstract":"<p><p>Theobroma cacao is the most economically important species within the genus Theobroma. Despite its importance, the intraspecific relationships of this species has not been fully elucidated due to insufficient molecular information. To facilitate a better understanding of the intraspecific evolutionary relationships of T. cacao, Sequencing technology has been to decode the plastid genomes, with the objective of identify potential DNA barcode genetic markers, explore intraspecific relationships, and infer divergence times. The plastid genome of the seven cocoa genotypes analyzed in this study, exhibited a typical angiosperm genomic structure. However, the structure of each plastid genome reflects notable changes in each genotype; for example, the infA gene was present in all the analyzed samples, unlike in previously published cocoa plastid genomes, while the complete ycf1 gene sequence has potential for use as DNA Barcoding in T. cacao. The estimated age of the node connecting T. cacao and T. grandiflorum, which was 10.11 Ma, supports this indication. It can be inferred that T. cacao diverged at approximately 7.55 Ma, and it is highly likely that T. cacao populations diversified during the Pliocene or Miocene. Therefore, it is crucial to perform mitochondrial and nuclear-based analyses on a broader spectrum of cocoa samples to validate these evolutionary mechanisms, including genetic estimates and divergence. This approach enables a deeper understanding of the evolutionary relationships among cocoa.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0316148"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: SAILoR: Structure-aware inference of logic rules.","authors":"Žiga Pušnik, Miha Mraz, Nikolaj Zimic, Miha Moškon","doi":"10.1371/journal.pone.0319814","DOIUrl":"10.1371/journal.pone.0319814","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0304102.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0319814"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Working life sequences over the life course among 9269 women and men in Sweden; A prospective cohort study.","authors":"Katalin Gémes, Katriina Heikkilä, Kristina Alexanderson, Kristin Farrants, Ellenor Mittendorfer-Rutz, Marianna Virtanen","doi":"10.1371/journal.pone.0319833","DOIUrl":"10.1371/journal.pone.0319833","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0281056.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 3","pages":"e0319833"},"PeriodicalIF":2.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}