PLoS ONE最新文献

{"title":"Transcriptome combined single-cell sequencing explores molecular mechanisms of ANGPTL4 in sepsis-induced acute lung injury.","authors":"Ying Qi, Changqi Zhou, Bing Chen","doi":"10.1371/journal.pone.0328551","DOIUrl":"https://doi.org/10.1371/journal.pone.0328551","url":null,"abstract":"<p><strong>Objective: </strong>Sepsis-induced acute lung injury (ALI) constitutes a critical clinical syndrome associated with high mortality rates, yet its molecular mechanisms remain inadequately elucidated. Recent evidence indicates that ANGPTL4 may influence inflammatory responses and endothelial barrier integrity; however, its cell-specific regulatory mechanisms in sepsis-associated ALI are not well understood. This study utilizes transcriptome profiling combined with single-cell sequencing to systematically analyze the spatiotemporal expression patterns and functional networks of ANGPTL4 during the progression of ALI.</p><p><strong>Methods: </strong>Gene expression profiles from acute lung injury patients were obtained from the Gene Expression Omnibus (GEO) database. Single-cell and intercellular communication analyses identified candidate gene sets. GSEA examined gene-immune cell relationships, while gene enrichment analysis explored key gene mechanisms. miRNA networks identified target miRNAs for these key genes. Molecular docking with AutoDock and the CTD database predicted drugs interacting with ANGPTL4. Additionally, in vitro experiments confirmed the Angptl4 gene expression level in sepsis-induced acute lung injury.</p><p><strong>Results: </strong>Angptl4 is a crucial marker for acute lung injury progression, potentially affecting pathways like the pentose phosphate pathway, fatty acid degradation, and PPAR signaling. It may interact with Q9BY76-Quercetin, but this requires further investigation. In vitro studies show a notable increase in Angptl4 expression compared to controls.</p><p><strong>Conclusion: </strong>The increased expression of ANGPTL4 may influence disease progression through mechanisms involving fatty acid metabolism, PPAR signaling, and the pentose phosphate pathway in murine models. Furthermore, its dual role in regulating inflammation through interactions with both pro-inflammatory and anti-inflammatory cells underscores its pivotal contribution to the pathogenesis of acute lung injury (ALI), thereby supporting the development of targeted therapies for sepsis-induced lung injury.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 7","pages":"e0328551"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering locomotor learning dynamics in people with Parkinson's disease.","authors":"Aram Kim, Nicolas Schweighofer, Giselle M Petzinger, James M Finley","doi":"10.1371/journal.pone.0326692","DOIUrl":"https://doi.org/10.1371/journal.pone.0326692","url":null,"abstract":"<p><p>Locomotor learning is important for improving gait and balance impairments in people with Parkinson's disease (PD). While PD disrupts neural networks involved in motor learning, there is a limited understanding of how PD influences the time course of locomotor learning and retention. Here, we used a virtual obstacle negotiation task to investigate whether the early stages of PD affect the acquisition and retention of locomotor skills. On Day 1, 15 participants with PD (Hoehn and Yahr Stage 1-2) and 20 age-matched controls were instructed to achieve a specified level of foot clearance while repeatedly stepping over two different virtual obstacles on a treadmill. We assessed online performance improvement on Day 1 and overnight retention after at least 24 hours on Day 2. We used a hierarchical Bayesian state-space model to estimate the learning rate and the degree of interference between the two obstacles. There was a 93% probability that people with PD learned the locomotor skill faster than controls, but there was limited evidence of group differences in interference between the two heights of obstacles. Both groups improved their performance to a similar magnitude during skill acquisition and performed similarly during retention on Day 2. Notably, a slower learning rate was associated with greater online performance improvement, while lower interference was linked to better overnight retention, and this effect was strongest for the control group. These results highlight that people with early-stage PD retain the ability to use multisensory information to acquire and retain locomotor skills. In particular, our finding that people with early-stage PD learned faster than age-matched controls may reflect the emergence of compensatory motor learning strategies used to offset early motor impairments in people with PD.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 7","pages":"e0326692"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of repetitive head impacts from a single season on the cognitive functioning of youth male soccer players.","authors":"Rachel S Watson, Lauren Sergio, Haojie Mao, Jeffrey S Brooks, James P Dickey","doi":"10.1371/journal.pone.0329329","DOIUrl":"https://doi.org/10.1371/journal.pone.0329329","url":null,"abstract":"<p><p>Repetitive head impacts have long-lasting negative effects on the cognition of athletes. For example, repetitive head impacts accumulated by adult professional soccer players throughout their careers result in long-term negative consequences on cognition. However, these effects on youth soccer players have not been extensively studied and need to be further evaluated. The purposes of this study were to quantify head impact exposure in youth elite soccer and to examine the effects of repetitive head impacts on the cognitive function of youth male soccer players. A prospective cohort study of a single boys U13 soccer team of 18 players (12.9 ± 0.2 years of age) was completed throughout a single soccer season (five months in duration). Head impact frequency data were recorded using impact monitoring mouthguards worn during practices and matches and subsequently video-verified. Cognitive function was assessed using cognitive-motor integration (CMI) tasks conducted before the first season match, every subsequent four weeks, and after the last match. Peak path velocity, absolute error, reaction time, full path movement time, and the number of direction reversals were CMI task outcome measures. Over a single soccer season, 1089 head impacts occurred with more head impacts occurring in practices (62.7%) than matches (37.3%). Midfielders experienced the most head impacts during practices (53.6% of practice impacts), and defenders experienced the most head impacts during matches (47.8% of match impacts). Repetitive head impact exposure by position was associated with significant decreases in absolute error (p < 0.001), increases in peak velocity (p < 0.001), and increases in reaction time (p < 0.001). Repetitive head impacts within a single soccer season were associated with measurable declines in some aspects of youth soccer players' cognitive function. Therefore, coaches should aim to reduce the number of head impacts experienced by male youth soccer players with a specific focus on reducing head impact exposure during practices.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 7","pages":"e0329329"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of stimulus amplitude-scaling approach on emotional responses to non-speech sounds.","authors":"Erin M Picou, Shae D Morgan, Elizabeth D Young, Samantha J Gustafson","doi":"10.1371/journal.pone.0328659","DOIUrl":"https://doi.org/10.1371/journal.pone.0328659","url":null,"abstract":"<p><p>In the study of auditory emotion perception, it is important to calibrate test sounds so their presentation level during testing is known. It is also often desirable to standardize the amplitude of the sounds so that each sound used in testing is approximately the same level. However, existing literature in the study of auditory emotion perception includes a mixture of techniques for standardizing amplitude across sounds. The purpose of this study was to compare the effects of two amplitude-scaling approaches on emotional responses to non-speech sounds, specifically standardization based on peak level or root-mean-square (rms) level. Nineteen young adults provided ratings of valence and arousal via an online testing program. Stimuli were non-speech sounds scaled in two ways, based on the stimulus' peak level or rms level. Ratings were analyzed using linear-mixed effects modeling to compare scaling methods; correlations between ratings and level within each scaling method were explored. Analysis revealed that the ratings of peak-scaled sounds were less pleasant and more exciting than were the ratings of rms-scaled sounds, although the effects were small in magnitude (~0.2 points on a 1-9 scale). Within rms-scaled sounds, peak level was not related to ratings of valence or arousal. However, within peak-scaled sounds, rms level was related to ratings of valence and arousal. Combined, these data suggest that amplitude standardization has a small effect on ratings overall, but investigators might be motivated to choose one approach over the other, depending on the research question. Rms-scaling reduces overall level as a cue for emotional responses, while peak-scaling maintains some natural variability in responses related to level. Finally, results are specific to this stimulus set. The effects of amplitude-scaling would be expected to be negligible for a stimulus set where the sounds have homogenous temporal dynamics.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 7","pages":"e0328659"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing proportion of mildly aged population in rural mitigates farmland abandonment in the farming-pastoral ecotone of northern China.","authors":"Yuling Jin, Guoliang Zhang, Xin Chen, Yi Zhou, Yukai Wei, Sicheng Mao, Haile Zhao, Wenting Liu, Zhihua Pan, Pingli An","doi":"10.1371/journal.pone.0328483","DOIUrl":"https://doi.org/10.1371/journal.pone.0328483","url":null,"abstract":"<p><p>Rural population aging has emerged as a widespread phenomenon, which can lead to farmland abandonment and pose unprecedented challenges to agricultural production and ecological sustainability in the farming-pastoral ecotone of northern China (FPENC). The dynamic changes in farmland abandonment from 2000 to 2020 were systematically explored using a trajectory-based land use change detection approach. Binary logit regression models were employed to analyze the driving mechanism of the current farmland abandonment based on 1,195 questionnaires, and then random forest models were used to predict future farmland abandonment trends under various scenarios. The results showed that (1) rural population aging had emerged as a significant challenge for Ulanqab, with the proportion of people aged 60 and above increasing from 12.3% in 2000 to 44.9% in 2020. Members of mildly aged households (60-69) were identified as the main agricultural labor force, accounting for 46.6%; (2) an overall downward trend of farmland abandonment was observed, decreasing from 295 km2 in 2000 to 273 km2 in 2020. However, the abandonment rate increased slightly from 3.03% to 3.66%, with higher abandonment rates concentrated in northern Ulanqab; (3) an increase in the proportion of the mildly aged population mitigated farmland abandonment, while an increase in the proportion of the severely aged population (≥70) exacerbated it. When other conditions remained unchanged, a 5% and 10% increase in the proportion of the mildly aged population corresponded to a decrease in farmland abandonment rates to 11.4% and 10.5%, respectively; (4) the mechanisms underlying abandonment behavior differed between young and elderly households. For each additional year of age for elderly households, the probability of farmland abandonment increased by 4.1%. Elderly households with higher levels of education, fewer farm laborers, smaller per capita farmland area, a higher proportion of dryland, larger quantities of farmland, and non-contracted farmland were more likely to abandon farmland; (5) under three Shared Socioeconomic Pathway scenarios (SSP1, SSP2, and SSP5), the proportion of abandoned farmland by farmers was projected to rise to 58.8%, 20.1%, and 58.8%, respectively. These findings provided new insights into the issue of abandoned farmland, particularly from a demographic perspective.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 7","pages":"e0328483"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144760984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of economic development of central business districts - A combination multi-criteria evaluation methodology.","authors":"Kaiyuan He, Bingbing Huang, Xinyu Liu, Shouzhen Zeng","doi":"10.1371/journal.pone.0326877","DOIUrl":"https://doi.org/10.1371/journal.pone.0326877","url":null,"abstract":"<p><strong>Background: </strong>The economic development of central business districts (CBDs) is a key driver of urban economic growth and enhances regional competitiveness. However, existing research predominantly focuses on macro-level analyses, lacking systematic and quantitative indicator systems for detailed evaluation of CBD economic development performance, while studies on urban office buildings or specific CBD components often neglect the broader context of the entire district.</p><p><strong>Objectives: </strong>This study aims to propose a multi-criteria evaluation system to effectively evaluate the economic development performance of CBDs, and provide theoretical references for a more comprehensive evaluation of the sustainable CBD growth in other regions.</p><p><strong>Methods: </strong>Firstly, the analytic hierarchy process (AHP) and entropy method are proposed to determine combination weights for each indicator. The VlseKriterijumska Optimizacija Kompromisno Resenje (VIKOR) method is then introduced to rank the economic development performance of CBDs. Finally, a numerical example of Zhejiang province is carried out to validate the results by comparing its rankings with existing methods.</p><p><strong>Results and conclusion: </strong>The multi-criteria evaluation of regional CBD economic development showed that the top two cities remained consistent across subjective, objective, and combined weights methods, while discrepancies in rankings for other cities were balanced by the combined weights approach. Meanwhile, minor variations in rankings highlighted the unique advantages of each method. These findings validate the effectiveness of combining subjective and objective methods for assessments. Future research should enhance data comprehensiveness and reliability through fieldwork to further improve the scientific validity of such evaluations.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 7","pages":"e0326877"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between transfer for surgery and mortality and disability among neonates in high income countries-A systematic review with meta-analysis.","authors":"Haribalakrishna Balasubramanian, Abhishek Srinivas, Prathamesh Khedkar, Anitha Ananthan, Diwakar Mohan, Nandkishore Kabra, Sanjay Patole","doi":"10.1371/journal.pone.0327971","DOIUrl":"https://doi.org/10.1371/journal.pone.0327971","url":null,"abstract":"<p><p>Birthing in a hospital with on-site surgical facilities (co-located care) is considered preferable for neonates with surgical conditions. However, it may not always be feasible. Whether transfer of surgical neonates from birth hospital to a surgical facility affects the outcomes of this cohort is unclear. We conducted a systematic review to investigate the association of birth location/transfer with all-cause mortality and disability among neonates with congenital/acquired surgical conditions. Data Sources from PubMed, Embase, CINAHL, and Web of Science were searched till December 2024. Studies from high-income countries (HICs) comparing infants transferred to a surgical center for surgery versus infants born and operated in a co-located care facility were included. Random effects model was used for meta-analysis. The quality of studies and certainty of evidence were assessed using Newcastle-Ottawa Scale and the GRADE framework respectively. The primary outcomes of interest were all-cause mortality and neurodevelopmental impairment at latest follow up. A total of 61 studies from 20 HICs were included. Compared to co-located care, transfer for surgery did not increase the odds of risk-adjusted and crude mortality in neonates with congenital diaphragmatic hernia [adjusted odds ratio (aOR):0.86 (0.49 to 1.49), 5 studies, 8366 infants; crude OR:0.68 (0.51 to 0.91, i.e., decreased mortality), 22 studies, 12970 infants], critical congenital heart disease [aOR:0.79 (0.42 to 1.48), 3 studies, 13485 infants; OR:1.04 (0.66 to 1.64), 10 studies, 14447 infants], surgical necrotizing enterocolitis [aOR:0.99 (0.61 to 1.61), 4 studies, 5891 infants; OR:1.03 (0.64 to 1.65), 5 studies, 5915 infants], gastroschisis [aOR:1.07 (0.68 to 1.68), 2 studies, 5294 infants; OR:0.80 (0.48 to 1.35), 11 studies, 8708 infants], tracheo-oesophageal fistula [aOR:0.97 (0.39 to 2.39), 1 study, 937 infants; OR:0.62 (0.37 to 1.04), 4 studies, 4050 infants], congenital or perinatal intestinal conditions [OR:2.69 (0.26 to 28.34), 4 studies, 1799 infants]. Neurodevelopmental outcomes between the groups were comparable in the three studies that reported this outcome. Whilst many included studies were of good quality, certainty of evidence was very low due to their observational design and heterogeneity. In conclusion, transfer of neonates from the birth hospital to another facility for surgical intervention was not associated with increased risk of mortality or disability. The evidence from this comprehensive meta-analysis would be useful for clinicians, parents and health policy makers. Systematic review registration: PROSPERO CRD 42024565651.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 7","pages":"e0327971"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing ISO standard microbiological techniques for isolating Campylobacter from poultry samples amidst challenges from extended spectrum beta lactamase producing Escherichia coli.","authors":"Keya Ghosh, Tahia Ahmed Logno, Tridip Das, Pangkaj Kumar Dhar, Damer Blake, Guillaume Fournie, Fiona Tomley, Richard A Stabler, Burhan Lehri, Paritosh Kumar Biswas","doi":"10.1371/journal.pone.0327963","DOIUrl":"https://doi.org/10.1371/journal.pone.0327963","url":null,"abstract":"<p><p>Isolation of zoonotic Campylobacter species has been standardized through the ISO 10272:2017 protocol. However, application of the protocol in a LMIC country failed to isolate Campylobacter due to extended-spectrum beta-lactamase (ESBL) producing Escherichia coli overgrowth during the Campylobacter selective enrichment phase. The aim of the study was to identify the contaminants and explore ways to mitigate them. A set of 25 non-Campylobacter contaminants isolated from chicken cecal samples grown on modified charcoal-cefoperazone-deoxycholate agar (mCCDA) during Campylobacter isolation were included. All isolates were screened for species identification and the presence of selected ESBL producing genes. Minimum inhibitory concentrations of tazobactam were measured using a microbroth dilution technique. The Campylobacter isolation protocol was then modified to inhibit the contaminants by adding the required tazobactam supplement to Preston broth or to mCCDA. All contaminants were found to be E. coli carrying at least one of the ESBL-producing genes blaTEM, blaCTX or blaSHV. The MIC of tazobactam sodium for ESBL-producing E. coli strains grown in Preston broth was at least 128 mg/L. Preston broth supplemented with tazobactam at 128 mg/L inhibited the growth of ESBL-producing E. coli but did not inhibit the growth of C. jejuni or C. coli. Interestingly, mCCDA plates supplemented with tazobactam at a much lower concentration of 4 mg/L could also prevent growth of ESBL-producing E. coli even without broth enrichment, increasing the efficiency of isolation of Campylobacter. Direct inoculation of cecal materials to mCCDA supplemented with tazobactam at 4 mg/L was recommended as the most cost-effective way to conduct Campylobacter surveillance targeting the cecal matrix instead of directly following ISO 10272:2017 protocol.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 7","pages":"e0327963"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting pulmonary function using thoracic deformity parameters in early onset scoliosis patients.","authors":"Mattan R Orbach, Patrick J Cahill, Annalise Noelle Larson, Ron El-Hawary, Oscar H Mayer, Sriram Balasubramanian","doi":"10.1371/journal.pone.0329199","DOIUrl":"https://doi.org/10.1371/journal.pone.0329199","url":null,"abstract":"<p><strong>Introduction: </strong>Thoracospinal deformities in early onset scoliosis (EOS) patients often lead to thoracic insufficiency syndrome, in which respiration or lung growth is impaired. Pulmonary function tests (PFTs) are used to assess pulmonary deficits but are challenging to comply with for EOS patients, who typically are between 5 and 10 years old. Thus, the objective was to predict PFT values in EOS patients directly from deformity parameters measured on routine radiographs.</p><p><strong>Methods: </strong>Corresponding preoperative radiographs and PFT values were retrospectively obtained from 47 EOS patients (13M/34F; mean age: 9.8 ± 3.0 years), and 19 literature-based deformity parameters were measured. Multiple linear regression (MLR) analyses using an exhaustive search feature selection method were used to estimate percent predicted forced vital capacity (%FVC) and forced expiratory volume in one second (%FEV1). Ten percent of the dataset was set aside to validate the predictive accuracy of the MLR models.</p><p><strong>Results: </strong>The additive contributions of multiple thoracospinal deformity parameters successfully yielded significant (p < 0.001) MLR models that predicted %FVC (R2 = 0.54) and %FEV1 (R2 = 0.59) in EOS patients. For the validation test, no significant differences (p > 0.05) in prediction error magnitudes were found.</p><p><strong>Conclusion: </strong>The developed MLR models provide the highest reported precision for predicting PFT values in EOS patients from radiographic deformity parameters. Additionally, a key subset of deformity parameters was identified, and their relative contributions to predicting PFT values provide quantitative metrics to guide surgical treatment.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 7","pages":"e0329199"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the smartphone addiction scale-short version (SAS-SV) in Honduran university students.","authors":"Sergio Hidalgo-Fuentes, Isabel Martínez-Álvarez, Fátima Llamas-Salguero, Iris Suyapa Pineda-Zelaya, César Merino-Soto, Guillermo M Chans","doi":"10.1371/journal.pone.0327226","DOIUrl":"https://doi.org/10.1371/journal.pone.0327226","url":null,"abstract":"<p><p>Problematic smartphone use (PSU) is a global issue associated with numerous adverse outcomes, especially among young people. One of the most widely used instruments to evaluate PSU is the Smartphone Addiction Scale-Short Version (SAS-SV). This study examined the psychometric properties of the Spanish version of the SAS-SV, including factorial validity, convergent validity, divergent validity, and reliability. The final sample comprised 530 students from a university in Honduras. Confirmatory factor analysis provided evidence supporting the validity of the instrument's internal structure. Reliability was estimated using McDonald's omega and Cronbach's alpha coefficients. Convergent validity was assessed through correlations with problematic Internet use, depression, anxiety, and stress. Measurement invariance tests were conducted across sex and age categories. The results indicated that the SAS-SV adequately fits a one-dimensional, reliable model and demonstrated measurement equivalence across groups of sex and age. Finally, the SAS-SV demonstrated a strong correlation with problematic Internet use, depression, anxiety, and stress. These findings support the SAS-SV as a valid and reliable instrument for examining PSU among university students in Honduras.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 7","pages":"e0327226"},"PeriodicalIF":2.6,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}