PLoS ONE最新文献

{"title":"Limited knowledge, low risk awareness, and eating out are associated with higher sugar-sweetened beverage consumption among adults aged 18-64 in Beijing.","authors":"Liyu Huang, Yiran Li, Yingjie Yu, Yan Zhang, Bo Yu, Xinyue Guo, Hairong He, Jiali Duan","doi":"10.1371/journal.pone.0334416","DOIUrl":"https://doi.org/10.1371/journal.pone.0334416","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to analyze the prevalence of sugar-sweetened beverage (SSB) consumption among residents aged 18-64 in Beijing and to identify associated influencing factors.</p><p><strong>Methods: </strong>A cross-section study was conducted from June 1,2024 to May 31, 2025, including 10,409 residents aged 18-64 in Beijing. Logistic regression was applied to examine demographic, behavioral, and knowledge-related factors associated SSB consumption.</p><p><strong>Results: </strong>The overall prevalence of SSB consumption was 38.7%. After adjusting for demographic factors, infrequent checking nutrition labels when purchasing food (ORs ranging from 1.348 to 1.570), infrequent active weight monitoring (ORs ranging from 1.290 to 1.428), dining out/taking out food >1 day/week (ORs ranging from3.495 to6.692), moderate-intensity physical activity less than 300 minutes a week (ORs ranging from 1.237 to 1.326), lack of knowledge about SSB (ORs ranging from 1.240 to 1.361), and awareness of the health risks of SSB (OR=1.198) were the risk factors for SSB consumption.</p><p><strong>Conclusions: </strong>SSB consumption among Beijing adults remains high. Men, urban residents, and younger adults represent priority groups for intervention. Strengthening nutrition education, improving health literacy, and promoting healthier dietary behaviors are essential strategies to reduce SSB consumption and improve population health.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0334416"},"PeriodicalIF":2.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prediction nomogram for metabolic syndrome in children: A retrospective study.","authors":"Xiongfeng Pan, Songting Li, Zhiyu Liu, Yan Zhong, Sha Zhao, Jun Qiu","doi":"10.1371/journal.pone.0334097","DOIUrl":"https://doi.org/10.1371/journal.pone.0334097","url":null,"abstract":"","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0334097"},"PeriodicalIF":2.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study of four-year changes in physical fitness among university students before and after COVID-19: 2019-2022.","authors":"Liangru Guo, Liang Jiang, Huizhi Huang","doi":"10.1371/journal.pone.0334088","DOIUrl":"https://doi.org/10.1371/journal.pone.0334088","url":null,"abstract":"<p><strong>Background: </strong>Physical fitness is a key indicator of health in youth and was significantly affected by the COVID-19 pandemic. However, longitudinal studies tracking pandemic-related fitness changes over four years in university students, particularly those enrolled before the pandemic, remain scarce. Understanding these long-term effects on body composition, fitness, and obesity prevalence-with attention to sex differences-is essential.</p><p><strong>Methods: </strong>This four-year cohort study included 4,413 Chinese university students (27% male, 73% female). From 2019 to 2022, participants underwent annual physical fitness assessments, measuring height, weight, vital capacity, long-jump, sit-reach, 50-m run, and sex-specific tests (1,000-m run/pull-ups for males; 800-m run/sit-ups for females). Statistical analyses included one-way ANOVA, LSD tests, and Chi-squared tests.</p><p><strong>Results: </strong>Weight and obesity rates increased significantly, with male obesity rising from 6.97% to 11.6% and female obesity from 1.9% to 3.45%. Overweight prevalence also grew slightly. Vital capacity peaked in 2021 but declined sharply in 2022 (males: 4,114.16 mL to 3,934.31 mL; females: 3,314.69 mL to 2,957.8 mL). Long-jump and sit-reach performance declined, and cardiorespiratory endurance (1,000-m/800-m runs) worsened post-2020. Female students improved in 50-m runs and sit-ups, while males showed no significant changes in 50-m runs or pull-ups.</p><p><strong>Conclusions: </strong>The pandemic significantly impacted university students' physical fitness over four years, exacerbating obesity risks and declining cardiorespiratory endurance, particularly in males. Schools should prioritize BMI management, obesity prevention, and targeted fitness interventions-emphasizing agility, strength, and late-stage cardiorespiratory training-to mitigate long-term health consequences.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0334088"},"PeriodicalIF":2.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and predictors of chronic kidney disease among hypertensive patients in Ethiopia: A Bayesian multivariate joint model.","authors":"Dejen Kahsay Asgedom, Habtamu Wagnew Abuhay, Lemma Derseh","doi":"10.1371/journal.pone.0334428","DOIUrl":"https://doi.org/10.1371/journal.pone.0334428","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HTN) is a major contributor to chronic kidney disease (CKD), a leading cause of global morbidity and mortality. In low-resource settings such as Ethiopia, where CKD risk factors remain understudied, identifying predictors and longitudinal blood pressure (BP) patterns associated with CKD incidence is crucial for early intervention. Therefore, this study aimed to determine the incidence and predictors of CKD, as well as its association with longitudinal BP changes, among hypertensive patients in Ethiopia.</p><p><strong>Methods: </strong>An institution-based retrospective follow-up study was conducted at the University of Gondar Comprehensive Specialized Referral Hospital. Using a Bayesian joint modeling approach, we integrated Cox proportional hazard and linear mixed effects models to evaluate the effects of time-dependent BP trajectories on CKD risk. The data were entered into the Kobo toolbox and analyzed with R software (version 4.3.1).</p><p><strong>Results: </strong>A total of 408 hypertensive patients were followed for 2322.83 person-years. At the end of the follow-up, 58/408 (14.22%) developed CKD, with an incidence density of 2.5 cases per 100 person-years (95% CI: 1.89-3.14). Both the current values and longitudinal the quarterly rate of change in BP were significantly associated with increased CKD risk. For systolic BP, the adjusted hazard ratio (AHR) was 6.25 (95% CrI: 2.85-9.85) for the current values and 3.75 (95% CrI: 3.16-7.95) for the quarterly rate of change. Similarly, the diastolic BP had an AHR of 4.32 (95% CrI: 2.35-8.27) for the current values and 5.64 (95% CrI: 4.24-10.82) for the quarterly rate of change. Additionally, age ≥ 65 years (AHR = 4.62; 95% CrI: 1.83-12.21), HDL-C < 40 mg/dL (AHR = 3.32; 95% CrI: 1.73-7.86), diabetes mellitus (AHR = 3.08; 95% CrI: 2.01-9.54), and proteinuria positivity (AHR = 2.85; 95% CrI: 1.48-5.55) were significant predictors of the incidence of CKD. These findings highlight the importance of close BP monitoring in Ethiopian hypertension clinics.</p><p><strong>Conclusion: </strong>The incidence of CKD in this study was relatively high compared with that reported in previous similar studies conducted in Ethiopia. Our findings confirm that time-dependent systolic BP and diastolic BP trajectories are strongly associated with an increased risk of CKD. Additionally, age, low HDL-C levels (<40 mg/dl), the presence of diabetes mellitus, and proteinuria were identified as significant predictors of CKD. Therefore, effective CKD prevention among hypertensive patients in Ethiopia hinges on regularly checking both their current blood pressure levels and how those levels change over time. We also need to keep a close eye on older patients (65 + years), low HDL-C, diabetes, and proteinuria to catch those at highest risk early and step in with care.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0334428"},"PeriodicalIF":2.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The impact of liquidity risk and credit risk on bank profitability during COVID-19.","authors":"Muhammad Haris, HongXing Yao, Hijab Fatima","doi":"10.1371/journal.pone.0334269","DOIUrl":"https://doi.org/10.1371/journal.pone.0334269","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0308356.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0334269"},"PeriodicalIF":2.6,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating metabolic changes in H9c2 cardiomyoblasts exposed to LPS: Towards understanding sepsis mechanisms.","authors":"Amandine Szczesnowski, Karine Pichavant-Rafini, Marie-Dominique Jezequel, Michaël Théron, Karelle Léon","doi":"10.1371/journal.pone.0334234","DOIUrl":"10.1371/journal.pone.0334234","url":null,"abstract":"<p><p>Sepsis is a major public health concern associated with high mortality rates, particularly due to sepsis-induced myocardial dysfunction (SIMD), which affects about 50% of septic patients. This study investigates how mitochondrial dysfunction contributes to SIMD by examining metabolic changes in H9c2 cardiomyoblasts exposed to varying concentrations of lipopolysaccharide (LPS), a bacterial endotoxin, to enhance our understanding of the relationship between infection severity and metabolic responses. H9c2 cells were treated with LPS at concentrations of 0.5, 1, 2.5, and 5 µg/mL for 24 or 48 hours. Cell viability was measured using the MTT assay, and gene expression related to inflammation and mitochondrial function was analyzed through Real-Time PCR. Mitochondrial respiration and energy metabolism were assessed using the Seahorse MitoStress kit. Results showed that while 2.5 and 5 µg/mL of LPS for 24 hours did not significantly impact cell viability, exposure to 5 µg/mL for 48 hours led to a 77.7% decrease in survival. Gene analysis indicated significant overexpression of IL-6 and SOD2, with consistent underexpression of mt-ND1. Mitochondrial respiration increased at lower LPS concentrations but decreased at 5 µg/mL. Glycolytic metabolism also increased at lower LPS levels but decreased at higher concentrations. Inhibition of metabolic pathways affected mitochondrial function, especially at higher LPS concentrations. Our findings suggest that LPS induces metabolic disturbances in H9c2 cells, with adaptive responses at lower concentrations. However, excessive exposure results in mitochondrial and cellular damage, decreasing overall metabolism.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0334234"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An enhanced spatial-temporal graph convolution network with high order features for skeleton-based action recognition.","authors":"Mohammed H Al-Hakimi, Ibrar Ahmed, Muhammad Haseeb, Taha H Rassem, Fahmi H Quradaa, Rashad S Almoqbily","doi":"10.1371/journal.pone.0332815","DOIUrl":"10.1371/journal.pone.0332815","url":null,"abstract":"<p><p>Skeleton-based action recognition has emerged as a promising field within computer vision, offering structured representations of human motion. While existing Graph Convolutional Network (GCN)-based approaches primarily rely on raw 3D joint coordinates, these representations fail to capture higher-order spatial and temporal dependencies critical for distinguishing fine-grained actions. In this study, we introduce novel geometric features for joints, bones, and motion streams, including multi-level spatial normalization, higher-order temporal derivatives, and bone-structure encoding through lengths, angles, and anatomical distances. These enriched features explicitly model kinematic and structural relationships, enabling the capture of subtle motion dynamics and discriminative patterns. Building on this, we propose two architectures: (i) an Enhanced Multi-Stream AGCN (EMS-AGCN) that integrates joint, bone, and motion features via a weighted fusion at the final layer, and (ii) a Multi-Branch AGCN (MB-AGCN) where features are processed in independent branches and fused adaptively at an early layer. Comprehensive experiments on the NTU-RGB+D 60 benchmark demonstrate the effectiveness of our approach: EMS-AGCN achieves 96.2% accuracy and MB-AGCN attains 95.5%, both surpassing state-of-the-art methods. These findings confirm that incorporating higher-order geometric features alongside adaptive fusion mechanisms substantially improves skeleton-based action recognition.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0332815"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application value of systemic immune-inflammation index in predicting severe Mycoplasma pneumoniae pneumonia.","authors":"Xiaocong Guo, Honglin Luo, Yaohui Song, Li Xiao, Xiaoya Xu, Yongcan Guo","doi":"10.1371/journal.pone.0333267","DOIUrl":"10.1371/journal.pone.0333267","url":null,"abstract":"<p><p>Mycoplasma pneumoniae (MP) is the primary causative agent of community-acquired pneumonia. Severe mycoplasma pneumoniae pneumonia (SMPP) can result in multiorgan damage and even respiratory failure or death. This study aimed to evaluate the predictive value of the Systemic Immune-Inflammation Index (SII) for SMPP. This retrospective study included 254 hospitalized children with MP infections (SMPP group, n = 103; non-SMPP group, n = 151). Patient data, including complete blood count parameters (white blood cell, absolute neutrophil, absolute lymphocyte, absolute monocyte, and platelet counts), C-reactive protein (CRP), serum amyloid A (SAA), and other markers, were collected. Furthermore, the SII, Systemic Inflammation Response Index (SIRI), neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) were calculated. T-tests and the Mann-Whitney U test were used to analyze differences between the groups. Logistic regression was applied to analyze the risk factors. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive performance of the SII and CRP for SMPP. The SMPP group exhibited significantly higher CRP and SAA levels, SII, NLR, MLR, PLR, and SIRI than the non-SMPP group (all P < 0.001). Logistic regression revealed that the SII (odds ratio [OR] = 1.006, 95% confidence interval [CI]: 1.001-1.010) and CRP (OR = 1.080, 95% CI: 1.041-1.120) were independent risk factors. ROC curve of the SII (area under the ROC curve = 0.883, sensitivity = 0.699, and specificity = 0.881) outperformed that of CRP. Thus, SII can serve as an effective biomarker for SMPP prediction. It can be a rapid and cost-effective method when combined with routine blood tests, thereby demonstrating considerable potential for clinical application.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0333267"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration on the bio-recycling agent and its recycled asphalt: Composition ratio, recycling efficiency and micro-mechanism.","authors":"Ying Fang, Zhengqi Zhang, Fei Zhou, Hengbin Liu, Zhongnan Tian","doi":"10.1371/journal.pone.0334052","DOIUrl":"10.1371/journal.pone.0334052","url":null,"abstract":"<p><p>Mineral oil-based asphalt recycling agents pose environmental concerns, prompting the search for sustainable alternatives. To this end, a bio-recycling agent (BRA) based on waste vegetable oil (WVO) was initially designed for the utilization of recycled asphalt pavement (RAP) through the orthogonal test, and then its physical-chemical and permeating properties were analyzed by a series of tests. Next, the bio-recycled asphalt binder was prepared and its several pavement behaviors were measured via adhesion, rheology and fatigue experiments, thus its recycling efficiency was validated. Ultimately, the microscopic mechanism of bio-recycled asphalt was revealed with differential scanning calorimetry (DSC) and atomic force microscope (AFM) tests. Research results showed that the composition of BRA was determined as base oil components: permeation components: polymer components: functional components = 120: 2: 13: 2.4. Compared to two commercial recycling agents (LBS and HRA), BRA possessed better recycling effect at the same dosage, which obviously restored the adhesion, high- and low-temperature rheological properties and fatigue resistance of aged asphalt, and the BRA increased fatigue life of aged matrix asphalt binder by about 60% compared to LBS at 9% dosage. Moreover, the recycled asphalt with suitable BRA dosage can adapt to a wider range of traffic grades than original asphalt, and for aged matrix and SBS-modified asphalt binder, it was recommended that the reasonable dosage of BRA was 7%-9% and 3%-5%, respectively. The samples recycled by three recycling agents all exhibited favorable thermal stability, and which was basically the same as or higher than that of the original asphalt. Besides, after incorporating the BRA, the number and size of bee-structures in aged asphalt decreased, while the roughness of asphalt surface slightly descended. Meanwhile, compared to two-commercial recycling agents, BRA had a significant improvement on the micro adhesion of aged asphalt, and behaved a better recycling effect on the aged asphalt.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0334052"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A social determinants of health survey in an Appalachian East Tennessee Medical Center: Initial findings and correlations with physical and emotional states of health.","authors":"Paul D Terry, Gulsah Onar, Jennifer Ferris, Robert Eric Heidel, Nate Brophy, Kritika Thapa, Laylan Shali, Heidi Worth, Gayathri Kumar, Tracy Walker, Rajiv Dhand","doi":"10.1371/journal.pone.0332087","DOIUrl":"10.1371/journal.pone.0332087","url":null,"abstract":"<p><strong>Background: </strong>People living in Appalachia experience inequities in health outcomes that may result from social determinants of health (SDH) and consequent barriers to healthcare.</p><p><strong>Objective: </strong>We aimed to assess SDH in our Appalachian patient population and examine associations between SDH and patients' physical and emotional well-being.</p><p><strong>Methods: </strong>We constructed and administered a SDH questionnaire in an urban medical center in Appalachian East Tennessee. Our survey included administration of the Short Form-36 (SF-36), which measures various domains of physical and emotional health. We used the SDH questionnaire to enumerate respondents' barriers to health (a total barrier score), with a maximum of 47 barriers identified. Descriptive statistics were calculated as frequencies and percentages. Spearman's and Pearson's (r) correlations and hierarchical multiple regression models were used to quantify associations between the SDH barrier scores and SF-36 subscales.</p><p><strong>Results: </strong>Our patients experienced substantial barriers to health (M = 11.61, SD = 5.10). SDH in our population included being underweight or overweight (BMI < 18.5 or ≥25; 71.2%), having a lower annual family income (<$50,000/year; 60.7%), and experiencing financial difficulty when seeking medical care (51.9%). Some differences in SDH prevalence according to sex were noted, such as a greater proportion of males (12.8%) than females (2.8%) having no health insurance. We observed statistically significant negative correlations between the SDH barriers score and all SF-36 subscales. After controlling for sex, age, and racial group, hierarchical multiple regression models showed a consistent negative relationship between SDH barrier score and all eight SF-36 subscales (B statistics ranged from -2.04 to -3.66).</p><p><strong>Conclusions: </strong>Patients in our Appalachian population experience a high number of barriers to accessing healthcare that are negatively correlated with measures of physical and emotional well-being. To optimize patient care, assessment of patients' physical and emotional health should complement the use of SDH questionnaires.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0332087"},"PeriodicalIF":2.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12510578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}