PLoS ONE最新文献

{"title":"Drug-related problems among type 2 diabetic patients in Sunwal Municipality of Western Nepal.","authors":"Sushma Chapagain, Nabin Pathak, Kushal Subedi, Prakash Ghimire, Bijay Adhikari, Niranjan Shrestha, Nim Bahadur Dangi","doi":"10.1371/journal.pone.0309781","DOIUrl":"https://doi.org/10.1371/journal.pone.0309781","url":null,"abstract":"<p><strong>Background: </strong>Several diseases co-exist with diabetes such as hypertension, and dyslipidemia, leading to cases of non-adherence, several drug interactions, and an increased risk of adverse drug reactions among patients, which are often termed as drug-related problems (DRPs). The role of pharmacists in high-income countries is well-defined in identifying DRPs among type 2 diabetes patients. However, these roles still need to be explored within low- and middle-income countries. The study aimed to identify DRPs in Type 2 diabetic patients.</p><p><strong>Methods: </strong>A community-based cross-sectional study was conducted in the Sunwal Municipality, Lumbini Province, Nepal from April to November 2021 where a stratified random sampling technique was employed to collect the data. The study included patients aged ≥ 18 years of either gender with type 2 diabetes who were prescribed at least one anti-diabetic medication. Patients were visited at their homes once identified through the community pharmacies, and a prescription review was conducted to identify the DRPs by using the Pharmaceutical Care Network Europe (PCNE) V8.02 tool and pertinent guidelines.</p><p><strong>Results: </strong>Among 182 patients, 97 (53.3%) had DRPs. Most of the patients were 50-60 years (n = 46; 25.3%), with a mean ± SD age of 55.43±14.46, as most were female (n = 94; 51.6%). Biguanides and sulfonylureas were the common classes of drugs prescribed. The major class of drug associated with DRPs were biguanides (n = 85; 49.7%), followed by sulfonylureas (n = 42; 24.6%). Metformin was the major drug associated with DRPs (n = 85; 49.4%). The major type of DRP identified was treatment effectiveness (n = 82; 79.61%), while patients not adhering to drug therapy (n = 97; 71.85%) was the leading cause of DRPs. DRPs were significantly associated with the duration of diabetes (p = .007) and the number of fruit servings (p = .007).</p><p><strong>Conclusion: </strong>The majority of the patients were found to have DRPs. The visiting patients at home by the pharmacists helped in identifying the DRPs and associated factors among type 2 diabetes patients, which may aid in the prevention and management of the disease.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0309781"},"PeriodicalIF":2.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of inorganic arsenic and methylarsenic in soil after derivatization by gas chromatography-mass spectrometry.","authors":"Wenzhi Zhao, Yuan Yang, Jintao Zhang, Tao Liu","doi":"10.1371/journal.pone.0313924","DOIUrl":"https://doi.org/10.1371/journal.pone.0313924","url":null,"abstract":"<p><p>Gas chromatography-mass spectrometry (GC-MS) has been applied to the analysis of arsenic forms in water, plants, and other samples; however, it has not been used to determine the form of arsenic in soil due to the complex soil matrix. The purpose of this study was to develop an analytical method for the simultaneous determination of inorganic arsenic species (As (III) and As (V)) and monomethylarsonic acid (MMA) in soil using GC-MS. The arsenic compounds were subjected to derivatization with 2,3-dimercapto-1-propanol (BAL) and subsequently analyzed using GC-MS. The BAL volume, derivatization reaction time, and temperature were optimized using standard added soil extracts. A reaction with 150 μL of BAL at 40°C for 30 min was selected as the optimal condition for quantitative derivatization of both inorganic arsenic (iAs) and MMA. The calibration curves exhibited linearity within the range of 5-100 ng/mL for each arsenic species, with correlation coefficients exceeding 0.997. The limits of detection for each arsenic species were determined to be 0.24 ng/mL and 1.31 ng/mL, respectively. The accuracy of the method was verified by the recovery of reference samples. The recovery experiments for reference samples showed that the recovery rates for As (III), As (V), and MMA were 89.5-93.7%, 88.5-105.6%, and 90.2-95.8% respectively, with precision ranging from 4.6 to 6.5%, 2.3 to 3.8%, and 2.4 to 6.3%. These results indicate good accuracy and precision. The accuracy of this method is not significantly different from that of liquid chromatography-inductively coupled plasma mass spectrometry (p = 0.05). The optimized method was sensitive, convenient and reliable for the extraction and analysis of different arsenic species in soil samples.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0313924"},"PeriodicalIF":2.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of managerial overconfidence for corporate digital transformation: Evidence from China.","authors":"Yi Jin, Chuxin Chen, Bo Liu","doi":"10.1371/journal.pone.0314231","DOIUrl":"https://doi.org/10.1371/journal.pone.0314231","url":null,"abstract":"<p><p>This article studies how managerial overconfidence shapes a firm's digital transformation and unpacks the pathway and the boundary condition. Using a sample of Chinese listed firms between 2011 and 2022, we find that managerial overconfidence exhibits a positive relationship with corporate digital transformation and the relationship is mediated by R&D investment. In addition, we demonstrate that compared to state-owned companies, R&D investment has a more significant positive effect on digital transformation in non-state-owned companies. This study contributes novel insights about the consequences of cognitive biases of top managers and extends the studies for investigating top managers in the digital transformation age. The findings offer implications for top managers who have to fully recognize the impact of overconfidence on the development of the companies and the impact of overconfident executives on corporate digital transformation depending on R&D investment to create value. In addition, this study also reminds Chinese policymakers to improve the efficiency of converting R&D investment into digital transformation in state-owned enterprises.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0314231"},"PeriodicalIF":2.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of percutaneous key lesion endoscopic lumbar decompression for the treatment of lumbar spinal stenosis in octogenarian patients.","authors":"Chien-Tung Yang, Cheng-Che Hung, Chih-Ying Wu, You-Pen Chiu, Jeng-Hung Guo, Hui-Ru Ji, Cheng-Di Chiu","doi":"10.1371/journal.pone.0300836","DOIUrl":"https://doi.org/10.1371/journal.pone.0300836","url":null,"abstract":"<p><strong>Introduction: </strong>With increasing life expectancy, degenerative lumbar spinal stenosis (LSS) has become a common problem in the geriatric population. LSS reduces the quality of life, limits daily activities, and requires therapeutic aids. We share our experiences of treating octogenarian patients with LSS with key lesion percutaneous single portal endoscopic unilateral laminotomy and bilateral decompression (sEndo-ULBD).</p><p><strong>Materials and methods: </strong>Nine octogenarian patients who underwent sEndo-ULBD between January 2021 and July 2022 were prospectively enrolled in this study. Their visual analogue score (VAS), Oswestry Disability Index (ODI), disc height, spondylolisthesis, lumbar lordotic angle, lumbar scoliotic angle, and spinal canal area before and after sEndo-ULBD were followed up for more than six months.</p><p><strong>Results: </strong>The VAS score was significantly reduced three months after the operation (p < 0.05). The postoperative ODI scores of all patients improved relative to their preoperative scores; this difference became significant in the third month after the operation (p < 0.05). Index-level disc height did not significantly change after the operation. Spondylolisthesis, lumbar lordotic angle, and lumbar scoliotic angle showed no significant curve progression. The spinal canal area increased markedly after sEndo-ULBD (p <0.05), with no known surgery-related complications.</p><p><strong>Conclusions: </strong>Key lesion sEndo-ULBD was an appropriate, safe, and effective treatment for octogenarian patients suffering from degenerative LSS. With an average follow-up of over one year, we did not find any significant progression in spinal curvature or instability. sEndo-ULBD is an ideal alternative to aggressive fusion fixation lumbar surgery for managing degenerative LSS in octogenarian patients with functional disability.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0300836"},"PeriodicalIF":2.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor productivity impacts of climate change and estimating the technical efficiency of cereal crop yields: Evidence from sub-Saharan African countries.","authors":"Ferede Mengistie Alemu, Yismaw Ayelign Mengistu, Asmamaw Getnet Wassie","doi":"10.1371/journal.pone.0310989","DOIUrl":"https://doi.org/10.1371/journal.pone.0310989","url":null,"abstract":"<p><p>The world aims to ensure environmental sustainability and consolidate agricultural factor productivity, yet the excruciating impact of climate change coincides and remains a persistent threat. Therefore, the study aims to estimate the technical efficiency of cereal crop yields and investigate the impacts of climate change on agricultural factor productivity. For this purpose, panel data from 35 sub-Saharan African countries between 2005 and 2020 was employed. For analysis, the pooled OLS and stochastic frontier models were employed. The results revealed that in the region, the average efficiency score for producing cereal crops between 2005 and 2020 was 83%. The stochastic frontier model results showed that labour contributed 51.5% and fertilizer contributed 5.7% to raising the technical efficiency of cereal crop yields, whereas arable land per hectare reduced the technical efficiency of cereal yields by 44.7%. The pooled OLS regression result showed that climate change proxies (CO2 and methane emissions) diminish land, labour, and fertilizers productivity at a 1% significance level, whereas GDP per capita boosts significantly the total factor productivity in agriculture. This confirmed how climate change reduced land, labour, and fertilizer input productivity. The results concluded that the region had a high level of technical efficiency; of which labour and fertilizer inputs contributed the largest share; however, their productivity has dwindled due to climate change. To increase cereal crop yield efficiency and limit the adverse effects of climate change on agricultural input productivity, the region should combine skilled and trained labour and fertilizer with sophisticated agriculture technologies, as well as adopt climate resistance technologies (weather- resistant variety seed and planting revolution mechanisms).</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0310989"},"PeriodicalIF":2.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classical cadherins evolutionary constraints in primates is associated with their expression in the central nervous system.","authors":"Max Petersen, Fredy Reyes-Vigil, Marc Campo, Juan L Brusés","doi":"10.1371/journal.pone.0313428","DOIUrl":"https://doi.org/10.1371/journal.pone.0313428","url":null,"abstract":"<p><p>Classical cadherins (CDH) comprise a family of single-pass transmembrane glycoproteins that contribute to tissue morphogenesis by regulating cell-cell adhesion, cytoskeletal dynamics, and cell signaling. CDH are grouped into type I (CDH 1, 2, 3, 4 and 15) and type II (CDH 5, 6, 7, 8, 9, 10, 11, 12, 18, 20, 22 and 24), based on the folding of the cadherin binding domain involved in trans-dimer formation. CDH are exclusively found in metazoans, and the origin and expansion of the gene family coincide with the emergence of multicellularity and vertebrates respectively. This study examined the evolutionary changes of CDH orthologs in primates and the factors that influence selective pressure to investigate the varying constraints exerted among CDH. Pairwise comparisons of the number of amino acid substitutions and of the ratio of non-synonymous substitutions per non-synonymous sites (dN) over synonymous substitutions per synonymous sites (dS), show that CDH2, CDH4, and most type II CDH have been under significantly higher negative selective pressure as compared to CDH1, CDH3, CDH5 and CDH19. Evaluation of gene essentiality as determined by the effect of germline deletion on animal viability, morphogenic phenotype, and reproductive fitness, show no correlation with the with extent of negative selection observed on CDH. Spearman's correlation analysis shows a positive correlation between CDH expression levels (E) in mouse and human tissues and their rate of evolution (R), as observed in most proteins expressed on the cell surface. However, CDH expression in the CNS show a significant E-R negative correlation, indicating that the strong negative selection exerted on CDH2, CDH4, and most type II CDH is associated with their expression in the CNS. CDH participate in a variety of cellular processes in the CNS including neuronal migration and functional assembly of neural circuits, which could profoundly influence animal fitness. Therefore, our findings suggest that the unusually high negative selective pressure exerted on CDH2, CDH4 and most type II CDH is due to their role in CNS formation and function and may have contributed to shape the evolution of the CNS in primates.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0313428"},"PeriodicalIF":2.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bayesian Mixture Model approach to expected possession values in rugby league.","authors":"Thomas Sawczuk, Anna Palczewska, Ben Jones, Jan Palczewski","doi":"10.1371/journal.pone.0308222","DOIUrl":"https://doi.org/10.1371/journal.pone.0308222","url":null,"abstract":"<p><p>This study aimed to introduce a novel Bayesian Mixture Model approach to the development of an EPV model in rugby league, which could produce a smooth pitch surface and estimate individual possession outcome probabilities. 99,966 observations from the 2021 Super League season were used. A set of 33 centres (30 in the field of play, 3 in the opposition try area) were located across the pitch. Each centre held the probability of five possession outcomes occurring (converted/unconverted try, penalty, drop goal and no points). Probabilities at each centre were interpolated to all locations on the pitch and estimated using a Bayesian approach. An EPV measure was derived from the possession outcome probabilities and their points value. The model produced a smooth pitch surface, which was able to provide different possession outcome probabilities and EPVs for every location on the pitch. Differences between team attacking and defensive plots were visualised and an actual vs expected player rating system was developed. The model provides significantly more flexibility than previous zonal approaches, allowing much more insightful results to be obtained. It could easily be adapted to other sports with similar data structures.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0308222"},"PeriodicalIF":2.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clinical and laboratory findings in MIS-C patients associated with COVID-19: An experience from the Northwest of Iran.","authors":"Mina Farshidgohar, Sonia Oveisi, Samira Dodangeh, Fatemeh Fawzi, Faezeh Maleki Sanjani, Alireza Razzaghi, Hossein Teimouri, Gerson Nakazato","doi":"10.1371/journal.pone.0313843","DOIUrl":"https://doi.org/10.1371/journal.pone.0313843","url":null,"abstract":"<p><p>This study aimed to evaluate the range of clinical and laboratory findings of multisystem inflammatory syndrome in children (MIS-C) with COVID-19 in a tertiary children's hospital in Northwest Iran during 2020-2022. According to the CDC guidelines, this cross-sectional study included 300 pediatric patients diagnosed with MIS-C. Data were collected retrospectively from medical records, focusing on symptoms, organ involvement, laboratory findings, and outcomes. Statistical analysis was performed using SPSS software, with significance set at p-values <0.05. The study population had a median age of 3 years, with a slight male predominance (57.3%). The most affected systems in MIS-C disease were hematological (87%), gastrointestinal (85%), and respiratory (67%). Laboratory analysis highlighted elevated inflammatory markers such as D-dimer (83.3%), ferritin (71.4%), and CRP (49.7%). Abnormal urinalysis was observed in 151 patients (50.3%), with glucosuria in 83 cases (27.7%) and proteinuria in 29 cases (9.7%). The study found a significant correlation between cardiovascular issues and elevated blood platelets, ESR, CRP, and troponin levels (P ≤ 0.01) but not with ferritin, albumin, or D-dimer levels. Also, the examination of disease outcomes in this study revealed that 81.7% of MIS-C patients were isolated during their hospital stay, 18.3% needed ICU care, and 1% died in hospital. We have presented an experience with distinct clinical and laboratory manifestations in MIS-C. Given the lower median age in this study compared to previous studies, reporting clinical and laboratory manifestations of MIS-C in pediatrics with a younger age is valuable for the diagnosis and treatment course. Some laboratory factors were risk factors for cardiovascular involvement, and consequently, echocardiography is recommended in MIS-C patients with these laboratory indications. Given the lack of a specific diagnostic test for this emerging disease, studies focusing on investigating clinical symptoms and findings are valuable.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0313843"},"PeriodicalIF":2.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gentiopicroside-Induced gastric cancer necroptosis via the HIF-1 signaling pathway: A study involving molecular docking and experimental validation.","authors":"Bo Xiong, Mingjie Fan, Zhihui Wang, Xiaolu Yang, Shan Cao, Jie Shen, Beibei Fan","doi":"10.1371/journal.pone.0311152","DOIUrl":"https://doi.org/10.1371/journal.pone.0311152","url":null,"abstract":"<p><strong>Objectives: </strong>Gentiopicroside is an effective treatment for several types of cancer, inducing numerous forms of programmed cancer cell death. However, there are few investigations into the role of necroptosis. By utilizing molecular docking, and experimental validation, this study aims to investigate whether gentiopicroside elicits necroptosis in gastric cancer.</p><p><strong>Methods: </strong>Using software PyMOL and AutoDock, gentiopicroside was docked with RIPK1, RIPK3, MLKL and HIF-1α proteins. And a cell study was performed based on SGC7901 cells. The necroptosis-related proteins and HIF-1 signaling pathways were explored using western blot (WB) analysis. Finally, an animal study was performed to test the inhibitory effect in vivo.</p><p><strong>Results: </strong>Docking studies indicated that the docking energies of gentiopicroside to necroptosis-related proteins and necroptosis-characteristic proteins are all below -5 kcal/mol. Additionally, gentiopicroside cells reduce gastric cancer viability and inhibit proliferation. Results from the animal experiments indicated that gentiopicroside inhibits the growth of the gastric cancer xenograft tumor. Western blot and immunohistochemistry (IHC) staining demonstrated that gentiopicroside higher p-receptor-interacting protein kinase 3(p-RIPK3) levels in vitro and in vivo.</p><p><strong>Conclusion: </strong>The findings of this study revealed that necroptosis is involved in the inhibitory effect of gentiopicroside toward gastric cancer.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0311152"},"PeriodicalIF":2.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of CCl4-induced liver inflammation and fibrosis by a NEU3 inhibitor.","authors":"Darrell Pilling, Trevor C Martinez, Richard H Gomer","doi":"10.1371/journal.pone.0308060","DOIUrl":"https://doi.org/10.1371/journal.pone.0308060","url":null,"abstract":"<p><p>Sialic acids are located on the ends of many glycoconjugates and are cleaved off by enzymes called sialidases (neuraminidases). Upregulation of neuraminidase 3 (NEU3) is associated with intestinal inflammation and colitis, neuroinflammation, and lung fibrosis. Genetic ablation of NEU3 or pharmacological inhibition of NEU3 reduces lung fibrosis in mice. To determine if inhibiting NEU3 can inhibit liver fibrosis in the commonly-used CCl4 model, in this report, we examined the effects of injections of the NEU3 inhibitor 2-acetyl pyridine (2AP). 2AP inhibited CCl4-induced weight loss in female but not male mice. 2AP attenuated CCl4-induced liver inflammation and fibrosis in male and female mice, but did not affect CCl4-induced steatosis. After CCl4 treatment, female but not male mice had significant increases in liver neutrophils, and 2AP attenuated this response. 2AP also reversed CCl4-induced liver desialylation and CCl4-induced increased expression of NEU3. Patients with pulmonary fibrosis have increased desialylation of some serum proteins, and elevated serum levels of NEU3. We find that sera from patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) have elevated desialylation of a serum protein and patients with NAFLD have increased levels of NEU3. These data suggest that elevated levels of NEU3 may be associated with liver inflammation and fibrosis, and that in mice this is ameliorated by injections of a NEU3 inhibitor.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0308060"},"PeriodicalIF":2.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}