PLoS ONE最新文献

{"title":"Utilization of Artificial Intelligence for the automated recognition of fine arts.","authors":"Ruhua Chen, Mohammad Reza Ghavidel Aghdam, Mohammad Khishe","doi":"10.1371/journal.pone.0312739","DOIUrl":"https://doi.org/10.1371/journal.pone.0312739","url":null,"abstract":"<p><p>Fine art recognition, traditionally dependent on human expertise, is undergoing a significant transformation with the integration of Artificial Intelligence (AI) and deep learning. This article introduces a novel AI-based approach for fine art recognition, utilizing Convolutional Neural Networks (CNNs) and advanced feature extraction techniques. Addressing the inherent challenges within this domain, we present a systematic methodology to enhance automated fine art recognition. By leveraging critical dataset characteristics such as objective type, genre, material, technique, and department, our method exhibits exceptional performance in classifying fine art pieces across diverse attributes. Our approach significantly improves accuracy and efficiency by integrating advanced feature extraction techniques with a customized CNN architecture. Experimental validation on a benchmark dataset highlights the efficacy of our method, indicating substantial contributions to the interdisciplinary field of fine art analysis.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0312739"},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histology-specific long-term oncologic outcomes in patients with epithelial ovarian cancer who underwent complete tumor resection: The implication of occult seeds after initial surgery.","authors":"Kazumasa Mogi, Masato Yoshihara, Ryo Emoto, Emiri Miyamoto, Hiroki Fujimoto, Kaname Uno, Sho Tano, Shohei Iyoshi, Kazuhisa Kitami, Nobuhisa Yoshikawa, Shigeyuki Matsui, Hiroaki Kajiyama","doi":"10.1371/journal.pone.0311421","DOIUrl":"https://doi.org/10.1371/journal.pone.0311421","url":null,"abstract":"<p><strong>Objective: </strong>Assessing the histology-specific prognosis of epithelial ovarian cancer (OvCa) is clinically challenging, especially in a patient population with a favorable prognosis. This study investigated the histology-specific long-term oncologic outcomes in OvCa patients who underwent complete tumor resection using a large-scale patient cohort form multiple institutions under a central pathological review system.</p><p><strong>Methods: </strong>A regional multi-institutional study was conducted from 1986 to 2019. Of the 4,898 patients with ovarian tumors enrolled, 1,175 patients who underwent complete tumor resection were classified into three classes based on clinically important prognostic factors: stage, cytology, ascites volume. For each class category, the effect of histology types on recurrence-free survival, the site of recurrence, and post-recurrence survival was evaluated.</p><p><strong>Results: </strong>Recurrence-free survival varied significantly across different histologies (P < 0.001). The risk of recurrence was higher in serous carcinoma compare to other histologies (P < 0.001). The site of tumor recurrence varied by the histology type. Multinominal logistic regression analysis revealed that mucinous histology had a significantly higher likelihood of developing recurrent tumors at distant sites from the peritoneum compared to other histologies (P = 0.002). Conversely, serous histology was associated with better post-recurrence survival (Log-rank P < 0.001).</p><p><strong>Conclusions: </strong>Long-term oncologic outcomes significantly differ by histology type in OvCa patients who have undergone complete tumor resection at the initial surgery. A careful evaluation of the clinical background is necessary for these patients, and further clinical research into individualized treatment approaches is essential.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0311421"},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a CNN-SK weld penetration recognition model based on the Mel spectrum of a CMT arc sound signal.","authors":"Wenlong Zheng, Kai Yang, Jiadui Chen, Haisong Huang, Jingwei Yang","doi":"10.1371/journal.pone.0311119","DOIUrl":"https://doi.org/10.1371/journal.pone.0311119","url":null,"abstract":"<p><p>Arc sound signals are considered appropriate for detecting penetration states in cold metal transfer (CMT) welding because of their noninvasive nature and immunity to interference from splatter and arc light. Nevertheless, the stability of arc sound signals is suboptimal, the conventional feature extraction methods are inefficient, and the significance of arc sound attributes for determining penetration statuses is often overlooked. In this study, a compact convolutional neural network (CNN) model is proposed for the adaptive extraction of features from arc sound signals. The model uses the Mel spectrum diagram of an arc sound signal obtained through a short-time Fourier transform (STFT) and a Mel filter bank conversion step as its input. To improve the recognition capabilities of the model, a novel CNN-selective kernel (SK) model for weld penetration recognition is introduced, which integrates the dynamic selection kernel network (SKNet) into the CNN architecture. The experimental results indicate that the CNN-SK model outperforms the traditional models, achieving an accuracy of 98.83% on the validation dataset. This model holds promise for assessing weld penetration in CMT welding applications. The project is available at https://github.com/ZWL58/data/tree/master.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0311119"},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocturnal playback experiments: The response of two European species of birds to singing of foreign male at night.","authors":"Kinga Buda, Jakub Buda, Michał Budka","doi":"10.1371/journal.pone.0313427","DOIUrl":"https://doi.org/10.1371/journal.pone.0313427","url":null,"abstract":"<p><p>Recent studies have shown that nocturnal singing in diurnal birds is a common phenomenon, however, the understanding of the mechanisms, functions and consequences of this behaviour has been lacking. We focused on the night singing of two diurnal songbirds-the yellowhammer and the common chaffinch that are widely distributed in Europe. We conducted day and night playback experiments, during which we broadcast songs of an unfamiliar male to the territory holder at two different stages of the breeding season, to examine whether the night singing in species which normally do not sing at night elicits responses from their conspecifics. We hypothesized that if nocturnal singing had no function, birds would ignore the night-time playback and respond only to the daytime intrusion. Otherwise, a response to the night-time playback would suggest that night singing may increase reproductive success but is limited by ecological factors. We found that, in contrast to the diurnal experiment, neither species responded vocally to the nocturnal playback. In yellowhammers, the probability of flights was higher during and after the playback than before it. This pattern was similar both during the day and night and did not differ between the stages of the season. For the common chaffinches, the probability of flight was low at night and constant across treatments, in contrast to the day when we observed more flights during the playback stage than before and after it. The playback of either species' songs at night caused the approach of predators, which was not observed during the day. The observed discrepancy in the probability of flights between the species suggests that nocturnal singing is a functional trait that affects other individuals in a specific context. Nocturnal singing does not seem to be a simple behaviour that extends during the day; it is a complex mechanism potentially dependent on specific conditions related to intraspecific communication, predatory pressure, local female access, or species' evolutionary history. We emphasise that those ecological and evolutionary factors need to be taken into account to understand this phenomenon widely.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0313427"},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study on mechanical response and crack evolution law of coal and sandstone under different stress environments.","authors":"Wenbao Shi, Qingzhao Xu, Zhuang Miao, Chao Qi, Jucai Chang, Chuanming Li, Aoyun Yan","doi":"10.1371/journal.pone.0313230","DOIUrl":"https://doi.org/10.1371/journal.pone.0313230","url":null,"abstract":"<p><p>In order to study the mechanical response and crack evolution law of different lithologic rock bodies under different stress environments in deep stress mines, based on the deviator stress theory, the actual triaxial disturbance unloading rock test system was used to simulate the stress occurrence environment of the original rock. The mechanical characteristics of different σ2 coal rock masses were studied, and the crack evolution law of coal and sandstone under different stress environments was analyzed. The results show that the increase of σ2 inhibits the deformation in the σ2 direction of coal and sandstone, promotes the expansion and deformation in the σ3 direction, and enhances its peak strength and elastic modulus. The development characteristics of internal cracks in rock mass are directly related to the stress environment, and the increase of σ2 promotes the increase of the proportion of coal RA value, weakens the proportion of sandstone RA value, aggravates the development of coal internal shear cracks, and inhibits the development of internal shear cracks in sandstone. The larger σ2, the greater the initial AE ringing count of coal and sandstone, and the greater the AE cumulative energy when the rock mass is finally damaged. At the same time, due to the self-organizing behavior in the process of crystal failure in sandstone, the cumulative energy curve of sandstone fluctuates in a step-like manner. The ringing count and cumulative energy increase suddenly, which can predict the imminent instability and failure of the rock, and the research results can provide an experimental basis for the sudden instability of deep high-stress roadways.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0313230"},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human development and entrepreneurship: A cross-country analysis of early-stage, intention, and discontinuation.","authors":"Cristian A Rojas, Felipe Chávez-Bustamante, Rolando Rubilar-Torrealba","doi":"10.1371/journal.pone.0313678","DOIUrl":"https://doi.org/10.1371/journal.pone.0313678","url":null,"abstract":"<p><p>Entrepreneurship is widely recognized as a vital driver of economic growth, yet its relationship through different stages with broader, non-purely monetary dimensions still needs to be explored. This research seeks to fill this gap by investigating the association between human development and entrepreneurship, recognizing the crucial role of environmental conditions in shaping entrepreneurial activity. Our cross-country Bayesian analysis shows strong evidence that a nation's level of human development is associated with entrepreneurial activity in three stages: early entrepreneurship, intention for future engagement, and discontinuation of ventures. Our findings expand the intricate relationship between entrepreneurship and economic variables, highlighting the importance of environmental conditions in shaping entrepreneurial behavior. This article emphasizes that promoting robust entrepreneurial ecosystems requires considering integral dimensions such as human development. Policymakers and researchers should broaden their perspectives to encompass these holistic dimensions to create an environment conducive to entrepreneurial growth.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0313678"},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological survey of anterior segment diseases in Japanese isolated island using a portable slit-lamp device in home-based cases in Miyako Island.","authors":"Eisuke Shimizu, Kazuhiro Hisajima, Shintaro Nakayama, Hiroki Nishimura, Rohan Jeetendra Khemlani, Ryota Yokoiwa, Yusuke Shimizu, Masato Kishimoto, Keigo Yasukawa","doi":"10.1371/journal.pone.0306845","DOIUrl":"https://doi.org/10.1371/journal.pone.0306845","url":null,"abstract":"<p><p>The ophthalmic diseases often affect the elderly and require proper diagnosis, treatments, and follow ups. However, many cases lack adequate eye care due to limited resources and decreased daily living activities among individuals. Despite the importance of ophthalmic home care, epidemiological research in this area has been lacking. This study utilized portable ophthalmological equipment to conduct an epidemiological research of anterior segment diseases in patients receiving home-based medical care in Japanese isolated island \"Miyako island\". A retrospective examination was conducted on home visit cases from a single facility in Miyako island (Dr. Gon Clinic). Data from 147 cases were collected and analyzed which the data are all recorded by the home care doctors and send the data to the cloud in order to make a diagnosis by the ophthalmologists. Findings included various anterior segment eye diseases such as Ptosis, meibomian gland dysfunction, conjunctival chalasis, corneal opacity, conjunctival hyperemia, pterygium, and cataract. Notably, over half of the cases (51.67%) had not undergone cataract surgery although the average age are notably high (85.69 ± 12.11 age of years). Among those without surgery, all showed signs of moderate to severe cataracts, with severity increasing with age. Additionally, a shallow anterior chamber depth was observed in one-third of these cases (33.63%) which considerable to receive a surgery to prevent the acute glaucoma attack. From our study, to ensure that patients in remote islands as Miyako island do not miss opportunities for eye care, there is an urgent need for the establishment of a supportive medical system.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0306845"},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter- and intraspecific responses of coral colonies to thermal anomalies on Palmyra Atoll, central Pacific.","authors":"Adi Khen, Michael D Fox, Maggie D Johnson, Christopher B Wall, Jennifer E Smith","doi":"10.1371/journal.pone.0312409","DOIUrl":"https://doi.org/10.1371/journal.pone.0312409","url":null,"abstract":"<p><p>Long-term monitoring of individual coral colonies is important for understanding variability between and within species over time in the context of thermal stress. Here, we analyze an 11-year time series of permanent benthic photoquadrats taken on Palmyra Atoll, central Pacific, from 2009 to 2019 to track the growth (i.e., increase in live planar area), pigmentation or lack thereof (\"discoloration\"), partial or whole-colony mortality, survival, and regrowth of 314 individual coral colonies of nine focal species from two reef habitat types. During this period, thermal anomalies occurred on Palmyra in conjunction with El Niño-Southern Oscillation events in both 2009 and 2015, of which the latter heatwave was longer-lasting and more thermally-severe. We found that coral responses varied by habitat, within and among species, and/or according to the degree of accumulated thermal stress. Nearly all species, particularly Stylophora pistillata and Pocillopora damicornis, responded more negatively to the 2015 heatwave in terms of colony-specific discoloration and reduction in live planar area. While discoloration was more prominent at the shallower reef terrace compared to the fore reef for this subset of colonies, the reef terrace exhibited greater stability of community-wide coral cover. Colony fate was associated with severity of discoloration at the time of warming: one year following the 2009 heatwave, more severely discolored colonies were more likely to grow, yet following the second heatwave in 2015, colonies were more likely to experience shrinkage or mortality. However, colonies that were more severely discolored in 2009 were not necessarily more discolored in 2015, suggesting that colony-specific factors may be more influential in governing responses to thermal stress.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0312409"},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 vaccination on preventive behavior: The importance of confounder adjustment in observational studies.","authors":"Laura Sità, Marta Caserotti, Manuel Zamparini, Lorella Lotto, Giovanni de Girolamo, Paolo Girardi","doi":"10.1371/journal.pone.0313117","DOIUrl":"https://doi.org/10.1371/journal.pone.0313117","url":null,"abstract":"<p><p>The COVID-19 pandemic has underscored the critical role of observational studies in evaluating the effectiveness of public health strategies. However, although many studies have explored the true impact of vaccination on preventive behavior, their results may be skewed by potential biases and confounding variables. This study examines the application of covariate adjustment and propensity score (PS) estimation, particularly through inverse probability treatment weighting (IPTW), to assess their performance in reducing bias in a framework featuring ordinal outcomes and cumulative logistic regression models, as commonly used in observational studies related to social sciences and psychology. Before applying these methods to the case study, we conducted a simulation study that accounted for the presence or absence of model misspecification in an observational scenario with ordinal outcomes, binary treatment, and a continuous confounder. Our findings demonstrate the effectiveness of combining covariate adjustment with PS methods in reducing bias and improving causal inference. These methods were subsequently applied to an Italian observational study on COVID-19 vaccine hesitancy conducted during the initial phase of the vaccination campaign (April-May 2021). Our analysis revealed that vaccination status had a limited short-term impact on the adoption of preventive measures. This study highlights the importance of employing appropriate adjustment techniques in observational research, particularly when evaluating complex behavioral outcomes. The results support the combined use of covariate adjustment and PS methods to enhance the reliability of findings, ultimately contributing to more informed public health decision-making.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0313117"},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality traits and other factors associated with psychotropic medication non-adherence at two hospitals in Uganda. A cross-sectional study.","authors":"Emmanuel Niyokwizera, David Nitunga, Joshua Muhumuza, Raissa Marie Ingrid Niyubahwe, Nnaemeka Chukwudum Abamara, Joseph Kirabira","doi":"10.1371/journal.pone.0302350","DOIUrl":"https://doi.org/10.1371/journal.pone.0302350","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Mental illnesses, like other chronic illnesses, require medications for both immediate, short term and long-term treatment. Medication adherence is the first and most important factor for better treatment outcomes. Non-adherence to psychotropic medications is associated with relapse, readmission, and early death. Psychological factors are among the common factors associated with non-adherence. Specific personality traits moderate the beliefs about medication that influence non-adherence to medications. Sociodemographic and clinical factors can also influence non-adherence to psychotropic medications. Non-adherence to psychotropic medications is high in Africa. Still, to the best of our knowledge, there is a lack of studies on the level of psychotropic medication non-adherence and associated personality traits. The aim was to determine the prevalence of psychotropic medication non-adherence and associated personality traits among people with mental illness attending Kampala International University Teaching Hospital (KIU-TH) and Jinja Regional Referral Hospital (JRRH). This study employed a hospital-based cross-sectional design. 396 adult patients suffering from mental illness were collected from KIU-TH and JRRH outpatient clinics. Medication adherence was assessed using the Medication Adherence Rating Scale (MARS) while personality traits were assessed by the short form of the Big Five Inventory (Ten Items Personality Inventory). In our study, we first assessed sociodemographic and clinical factors influencing psychotropic medication non-adherence (confounders). A questionnaire with sociodemographic information was also used. Logistic regression was used to assess personality traits and other factors associated with psychotropic medication non-adherence. The majority of the study participants were males (59.1%), from rural areas (74.2%), with a secondary educational level (47.5%) and unemployed (44.9%). The prevalence of psychotropic medication was 46.21%. Poor family support (aOR = 6.915, CI = 3.679-12.998, P&lt;0.001), belief in witchcraft/sorcery (aOR = 2.959, CI = 1.488-5.884, P = 0.002), experiencing side effects (aOR = 2.257, CI = 1.326-3.843, P = 0.003), and substance use (aOR = 4.174, CI = 2.121-8.214, P&lt;0.001) were factors significantly associated with psychotropic medication non-adherence. The personality traits significantly associated with psychotropic medication non-adherence after controlling for the confounders were neuroticism (aOR = 7.424, CI = 3.890-14.168, P&lt;0.001) and agreeableness (aOR = 0.062, CI = 0.024-0.160, P&lt;0.001). In this study, medication non-adherence was high. Non-adherent patients were more likely to have predominant neuroticism personality traits. Non-adherence to medication was shown to be less common in individuals with agreeableness personality traits. Other factors associated with psychotropic medication non-adherence were poor social support, witchcraft beliefs, the presence of side effects, and substance","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"19 11","pages":"e0302350"},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}