匈牙利口腔癌:流行病学概况(2015-2019)。

IF 2.9 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
PLoS ONE Pub Date : 2025-07-03 eCollection Date: 2025-01-01 DOI:10.1371/journal.pone.0327566
Amr Sayed Ghanem, Laszlo Trefan, Ildikó Márton, Petra Fadgyas-Freyler, Attila Csaba Nagy, Marianna Móré
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引用次数: 0

摘要

目的:匈牙利是口腔癌标准化发病率最高的国家之一。这是第一个国家分析,旨在量化匈牙利2015年至2019年按性别和年龄划分的年龄标准化口腔癌发病率,确定从诊断到死亡的中位间隔,并评估合并症患病率及其预后影响。方法:我们使用来自匈牙利国家健康保险基金数据库的真实数据。计算调整后的标准化发病率和再入院率;分析口腔癌患者的诊断至死亡时间及合并症的影响。结果:总体而言,发病率和住院率在研究期间有所下降,男性和老年组的发病率和住院率均较高。从2017年的发病率来看,特定地区与其他地区之间存在显著差异;三个地区的住院率与其他地区有显著差异。几乎一半(46.3%)的患者在诊断后一年内死亡,男性死亡率为31.8%,女性死亡率为14.5%。口腔癌的存在导致两种模型死亡率的奇比分别为5.20(95%可信区间,5.03,5.38)、5.84(95%可信区间,5.64,6.04)。口腔癌患者合并症的数量和相对风险高于对照组。结论:该研究强调了匈牙利在降低口腔癌发病率方面取得的进展,但在降低死亡率和提高诊断后第一年的生存率方面仍存在重大挑战。该研究还显示,口腔癌是该国的一个严重负担,尤其是对男性而言。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oral cancer in Hungary: An epidemiological profile (2015-2019).

Objective: Hungary is among countries with the highest standardised rate oral and mouth cancers. This first national analysis aimed to quantify age-standardized oral cancer incidence in Hungary from 2015 to 2019 by sex and age, determine the median interval from diagnosis to death, and evaluate comorbidity prevalence and its prognostic impact.

Methods: We used real-world data from the Hungarian National Health Insurance Fund database. Adjusted, standardised incidence- and hospital readmission rates were calculated; time between diagnosis and death and effect of comorbidities coexisting with oral cancer were analysed.

Results: Generally, incidence and hospitalisation rates decreased in the studied period, for males and older age group both rates were higher. From year 2017 for incidence rates significant differences were found between a particular region and the other regions; and hospitalisation rates differed significantly for three regions from other regions. Almost half (46.3%) of the patients died within a year after diagnosis, mortality rates were 31.8% for males and 14.5% for females. Existence of oral cancer indicated 5.20 (95% confidence interval, 5.03,5.38), 5.84 (95% confidence interval, 5.64,6.04) odd ratios for mortality by two models. Number and relative risk of comorbidities were higher among patients diagnosed with oral cancer than in the control population.

Conclusion: The study highlighted progress in reducing oral cancer incidence rates in Hungary, however significant challenges remain in reducing mortality rates and improving survival within the first year of diagnosis. The study also showed oral cancer a serious burden in the country, especially for males.

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来源期刊
PLoS ONE
PLoS ONE 生物-生物学
CiteScore
6.20
自引率
5.40%
发文量
14242
审稿时长
3.7 months
期刊介绍: PLOS ONE is an international, peer-reviewed, open-access, online publication. PLOS ONE welcomes reports on primary research from any scientific discipline. It provides: * Open-access—freely accessible online, authors retain copyright * Fast publication times * Peer review by expert, practicing researchers * Post-publication tools to indicate quality and impact * Community-based dialogue on articles * Worldwide media coverage
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