PLoS ONE最新文献

{"title":"Study of the rice yield variations under water saving scenarios using DSSAT crop model.","authors":"Chih-Yu Hsieh, Hungyen Chen, Yi-Chien Wu, Chih-Yung Teng, Cheng-Hong Li","doi":"10.1371/journal.pone.0329509","DOIUrl":"10.1371/journal.pone.0329509","url":null,"abstract":"<p><p>The current instability of water resources poses a major challenge and may lead to a food shortage crisis. To address this issue and to cope with the challenges of future extreme weather events and insufficient water resources, it is imperative to develop water-saving cultivation measures. This study used the long-term historical yield data of three rice varieties, TK9, TNG67 and TCS10, from an agricultural research station in Taiwan, simulated two water-saving cultivation experiments using the DSSAT crop model, and established a yield model based on the water-saving ratio, aiming to recommend appropriate irrigation water for Taiwan rice varieties. The goal was to save water while ensuring that the yield is not affected. Through water-saving cultivation simulation experiments, we estimated that under the condition of maintaining more than 90% of rice yield, water-saving irrigation treatment of rice in two different cropping seasons can save about 48% to 100% and 42% to 61% of irrigation water respectively. For irrigation treatment during sensitive growth stages, significant water-saving effects can be achieved, which are about 40% to 75% and 55% to 91% respectively. This study suggests that in the case of water shortage, it is possible to consider moderately increasing the water-saving ratio and implementing irrigation during sensitive growth periods, so as to effectively cope with future water shortage scenarios and achieve sustainable rice production while saving water resources.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 8","pages":"e0329509"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hidden influence: Medical students' knowledge and attitude of conflict of interest-A cross-sectional study in Jeddah, Saudi Arabia.","authors":"Ramy Samargandi, Rawad H Alsayed, Mazen A Alqarni, Sohail S Alghamdi, Adel Alzahrani, Anas Almutairi, Safinaz M Alshiakh, Abdullah S Algarni","doi":"10.1371/journal.pone.0328884","DOIUrl":"10.1371/journal.pone.0328884","url":null,"abstract":"<p><strong>Introduction: </strong>Conflicts of interest (COI) pose ethical challenges in medical education and clinical practice, potentially influencing decision-making. While COI policies and education vary globally, inconsistent training leaves medical students vulnerable to industry influence. In Saudi Arabia, COI education remains underexplored. This study assesses medical students' knowledge, attitudes, and exposure to COI, aiming to identify gaps and inform educational improvements.</p><p><strong>Methodology: </strong>A cross-sectional study was conducted among 392 medical students from multiple universities in Jeddah, Saudi Arabia. A validated questionnaire was administered to assess COI knowledge, attitudes, and exposure to industry interactions. Data were analyzed using IBM SPSS 29.0, with statistical significance set at p < 0.05.</p><p><strong>Results: </strong>A total of 392 participants were included. Overall, 71.4% of students were able to define COI, while 28.6% lacked awareness. Clinical students had significantly higher knowledge scores than preclinical students (p = 0.001). Grade Point Average (GPA) was significantly associated with attitudes toward COI, with students who had excellent GPAs scoring the highest (p < 0.001). No significant differences were observed in knowledge or attitude scores based on gender, research experience, and university affiliation. Over half of the students (52.6%) felt inadequately educated about COI, and 48.5% had never attended a COI lecture. Clinical students (65.2%) reported more interactions with pharmaceutical representatives than preclinical students (34.8%).</p><p><strong>Conclusion: </strong>While medical students generally recognize COI, gaps in knowledge and formal education persist. Clinical exposure appears to enhance knowledge, yet inconsistent education leaves students vulnerable to industry influence. Strengthening COI education within medical curricula is essential to promote ethical decision-making and uphold professional integrity.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 8","pages":"e0328884"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Multiple Platforms Effect (MPE): A quantification of how exposure to similarly biased content on multiple online platforms might impact users.","authors":"Robert Epstein, Amanda Newland, Thomas Peeler, Basil Thaddeus","doi":"10.1371/journal.pone.0327209","DOIUrl":"10.1371/journal.pone.0327209","url":null,"abstract":"<p><p>Over the past decade, controlled studies have identified nearly a dozen new forms of manipulation that can be used by search engines, social media platforms, microblogging platforms, and intelligent personal assistants. A recent study has shown that when users were exposed repeatedly to similarly biased content on the same platform, the net impact of those exposures was additive. We now ask the following: What happens when users are exposed to similarly biased content generated by different means on multiple online platforms? In the present experiment, which was randomized, controlled, counterbalanced, and double-blind, we exposed people to similarly biased content generated by different means on three different platforms - simulations of Google Search, Alexa, and X (f.k.a., Twitter) - presented successively and in a random order. We found that the impact of successive exposures was additive for both opinions and voting preferences pertaining to political candidates. Overall, the number of undecided voters voting for the favored candidate increased with each successive platform exposure by 42.4%, then 56.5%, then 66.7% over the pre-exposure level. We speculate that if Big Tech companies share values or political preferences, their net effect on our elections might be considerably greater than the effect of any individual company.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 8","pages":"e0327209"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When to stop: Understanding the landscape of extreme-duration cardiopulmonary resuscitation practices among pediatricians in Sudan.","authors":"Mohammed Abdulrahman Alhassan","doi":"10.1371/journal.pone.0328704","DOIUrl":"10.1371/journal.pone.0328704","url":null,"abstract":"<p><strong>Background: </strong>Pediatric cardiopulmonary resuscitation (CPR) is a life-saving intervention, but its effectiveness in extreme durations remains debated. This study aimed to explore the frequency and decision-making regarding prolonged CPR (PCPR) practices in hospitalized Sudanese children.</p><p><strong>Methods: </strong>A web-based cross-sectional survey was conducted among pediatricians and pediatric trainees in Sudan. The survey investigated their experience with prolonged, ultra-prolonged, and extreme-duration CPR and factors influencing termination decisions.</p><p><strong>Results: </strong>Ninety-six Sudanese pediatricians and trainees responded to the survey, reporting varied experiences with prolonged CPR durations: over half (51%) and 81% of respondents reported encountering extreme-duration (> 12 hours) and ultra-prolonged (> 2 hours) CPR at least once, respectively. Around 5% and 1% reported to have encountered CPR durations of 48-72 hours and more than 72 hours, respectively, while 18% reported a 12-14-hour as their record high CPR duration. Four participants reported encountering extreme-duration (> 12 hours) CPR more than 15 times. Respondents most frequently (41%) cited the absence of a pulse and heartbeat as the primary factor for terminating CPR. A vast majority acknowledged ethical considerations (84%) and a lack of clear protocols (83%) as a barrier to terminating PCPR. Thematic analysis of an open question revealed a critical need for a standardized protocol addressing PCPR, enhanced CPR training, and better post-resuscitation support.</p><p><strong>Conclusions: </strong>This study revealed a relatively high frequency of extended-duration CPR in Sudanese pediatric settings. Termination decisions focused on cardiac activity becoming clinically undetectable rather than brain death signs or specific cutoff CPR durations. The absence of a clear protocol on when to terminate CPR seems to contribute the most to this phenomenon. Further research on patient outcomes after prolonged CPR in this context is warranted.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 8","pages":"e0328704"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hard input, soft management and student engagement: How institutional actions promote innovation ability and academic performance among top innovative talent.","authors":"Tianbao Zhang, Weihai Huang, Zhimin Liu","doi":"10.1371/journal.pone.0328842","DOIUrl":"10.1371/journal.pone.0328842","url":null,"abstract":"<p><p>The training and cultivation of innovative talent, especially top-quality talent, cannot be explained fully by reference to a simple linear input‒output model. Research that can open the \"black box\" that characterizes this process has important theoretical and practical significance with respect to efforts to promote the development of high-quality education. By reference to a sample consisting of 1,500 graduating doctoral students who participated in a national stratified sampling survey in China, we develop a structural equation model with the goal of investigating the different roles played by the hard inputs and soft management employed by institutions in the task of cultivating top-quality innovative doctoral students as well as the specific paths associated with this influence. Our analysis reveals that promoting learning initiative among doctoral students and regulating their level of scientific research engagement are important ways in which various institutional inputs, especially soft management measures, can affect the intrinsic innovation ability of doctoral students, whereas efforts to encourage doctoral students to pursue top-quality academic achievements on the basis of their acquisition of relevant capabilities are related mainly to the hard inputs provided by institutions.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 8","pages":"e0328842"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Exploring a method for extracting concerns of multiple breast cancer patients in the domain of patient narratives using BERT and its optimization by domain adaptation using masked language modeling.","authors":"Satoshi Watabe, Tomomi Watanabe, Shuntaro Yada, Eiji Aramaki, Hiroshi Yajima, Hayato Kizaki, Satoko Hori","doi":"10.1371/journal.pone.0329664","DOIUrl":"10.1371/journal.pone.0329664","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0305496.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 8","pages":"e0329664"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding community proximity discourse: A mixed-methods comparative analysis of online local and national newspapers in Romandy, Switzerland.","authors":"Victor Bros, Daniel Gatica-Perez","doi":"10.1371/journal.pone.0328059","DOIUrl":"10.1371/journal.pone.0328059","url":null,"abstract":"<p><p>This paper presents a mixed-method approach to analyzing news media, combining quantitative linguistic metrics with qualitative discourse frameworks. We first extract linguistic features such as quotations, readability levels, and lexical richness, then perform named entity recognition and topic modeling. To add depth, we apply Fairclough's model of critical discourse analysis-highlighting social and cultural contexts-together with Goffman's frame analysis of social behavior, enabling a systematic comparison of narrative strategies and community engagement. We provide new evidence on how local and national papers diverge not only in content, but also in temporal framing, participatory practices, and the construction of proximity. We validate this pipeline by comparing local and national newspapers in Romandy, Switzerland, a media landscape where local press agencies currently face intense economic pressures and widespread layoffs. Our findings reveal notable divergences in narrative construction and audience engagement: local outlets focus on fostering a sense of community and direct connection with readers, whereas national outlets employ more wide-ranging, sophisticated storytelling to appeal to a broader audience. By synthesizing quantitative and qualitative insights, our study moves beyond descriptive comparison to show how distinct editorial logics shape identity and democratic participation in a transforming media landscape. The study's integrated analytical framework underscores the importance of a comprehensive, multi-level perspective on media strategies and audience dynamics, particularly in an era of rapid editorial and economic transformations.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 8","pages":"e0328059"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Derivation of a novel multi-gene prognostic model based on regulated cell death pathways in acute myeloid leukemia: A comprehensive bioinformatic analysis integrating gene expression, mutation profiling, and immune infiltration.","authors":"Ali Ahmadi, Amir Abas Navidinia, Davood Bashash, Behzad Poopak, Shadi Esmaeili","doi":"10.1371/journal.pone.0328412","DOIUrl":"10.1371/journal.pone.0328412","url":null,"abstract":"<p><strong>Background: </strong>Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy with dismal survival outcomes, where dysregulation of regulated cell death (RCD) pathways plays a pivotal role in leukemogenesis and therapeutic resistance.</p><p><strong>Methods: </strong>Differential expression analyses were performed comparing AML samples with healthy bone marrow. Diagnostic differentially expressed genes (DEGs) were then intersected with curated gene sets representing apoptosis, pyroptosis, autophagy, necroptosis, and ferroptosis to derive an RCD-based gene signature. Prognostic markers were identified by univariate Cox regression, and these markers were refined using LASSO regression to construct a multi-gene prognostic model that generated an individual risk score (RS) for each patient. The performance of the model was validated internally through Kaplan-Meier survival analyses and receiver operating characteristic (ROC) curves for 1-, 3-, and 5-year survival, and externally confirmed in an independent TARGET-AML cohort. In addition, mutation analysis was conducted using the maftools package, and immune infiltration profiling was performed with CIBERSORT and xCell to characterize the molecular landscape of the risk groups.</p><p><strong>Results: </strong>Our integrative approach yielded a four-gene prognostic model incorporating ARHGEF35, GSN, ELANE, and AKT3. High RS was strongly associated with adverse overall survival, with Kaplan-Meier analyses showing p-value < 0.0001 in the training cohort and p-value = 0.0026 in the testing cohort. The model demonstrated robust predictive accuracy with AUC values of 82%, 87%, and 91% for 1-, 3-, and 5-year survival in the training set, and 65%, 81%, and 94% in the testing set. Mutation analysis revealed that DNMT3A and RUNX1 mutations were significantly enriched in high-RS patients (p-value = 0.0015 and p-value = 0.0086, respectively), whereas KIT mutations were more prevalent in low-RS patients (p-value = 0.0058). Immune profiling indicated that high-RS patients had increased M2 macrophage infiltration (p-value = 0.0027) and reduced resting mast cells (p-value = 0.0033).</p><p><strong>Conclusion: </strong>These findings establish that an RCD-based multi-gene risk model can robustly stratify AML patients by prognosis and illuminate underlying genomic and immunologic mechanisms, thereby offering promising avenues for personalized therapeutic strategies.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 8","pages":"e0328412"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions of substrates and phosphinyl containing inhibitors with bacterial and human zinc proteases.","authors":"Fatema Amatur Rahman, Imin Wushur, Ida Kristine Østnes Hansen, Tor Haug, Klara Stensvåg, Bibek Chaulagain, Tra-Mi Nguyen, Olayiwola Adedotun Adekoya, Nabin Malla, Jan-Olof Winberg, Ingebrigt Sylte","doi":"10.1371/journal.pone.0329362","DOIUrl":"10.1371/journal.pone.0329362","url":null,"abstract":"<p><p>Inhibitors of bacterial virulence is suggested to be a promising strategy in the fight against bacterial resistance. The zinc metalloproteases (MPs) thermolysin (TLN), pseudolysin (PLN, LasB) and aureolysin (ALN) are bacterial virulence factors from the M4 family of proteases structurally resembling human zinc MPs. Knowledge about the binding modes of substrates and inhibitors with the bacterial and human zinc MPs is therefore fundamental for developing inhibitors without strong off-target effects. In the present paper, we studied the molecular interactions and cleavage of TLN, the prototype enzyme of the M4 family, with the substrate Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH (ES005) by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) and molecular dynamics (MD) simulations. Enzyme inhibition kinetic studies were used to test 5 compounds (H-1 - H-5) containing phosphinyl as the zinc binding group for their inhibition of TLN, PLN and ALN and of the human matrix metalloproteases MMP-9 and MMP-14. The MALDI-TOF MS results revealed that TLN cleaves ES005 at three sites. The most abundant cleavages were between Ala and Phe, and between Gly and Phe, while the third was between Ser and Ala. MD simulations with Ala or Gly in the S1 subpocket and Phe in S1' subpocket gave stable interactions between ES005 and TLN. The MD simulations with Ser in the S1 subpocket and Ala in the S1' subpocket showed larger movements of the substrate relative to the catalytic site than the others, which may explain that the Ser-Ala cleavage product was less abundant than the cleavage products from Ala-Phe and Gly-Phe. H-1 inhibited MMP-14 and MMP-9 with inhibition constants ranging from 0.89 to 30 μM but did not inhibit the bacterial zinc MPs. Induced fit docking showed that the aromatic group of H-1, that entered the S1' subpocket of the human MMPs, is too big for the S1' subpocket of the bacterial zinc MPs. H-2 inhibited the human MMPs with inhibition constants ranging from 0.53 μM (MMP-9) to 3.0 μM (MMP-14) and the bacterial zinc MPs with inhibition constants ranging from 2.5 μM (TLN) to 80 μM (ALN). Induced fit docking indicated that H-2 interacted quite differently with the human and bacterial zinc proteases, but with primed and unprimed subpockets in both. H-3, H-4 and H-5 did not inhibit any of the zinc MPs with inhibition constants < 100 μM. The MD simulations of ES005 with TLN showed that the MALDI-TOF MS results could be explained by that a Phe in S1' subpocket generate more stable interaction with TLN than an Ala in that subpocket. The docking studies indicated that the size of the S1' subpocket is an important determinant for inhibitor selectivity between bacterial and human zinc MPs.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 8","pages":"e0329362"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the content and processes of patient-derived quality of care indicators for those affected by multiple long-term conditions (MLTC): A scoping review protocol.","authors":"Sara Tavares, Arad Reisberg, David Belsey, Ania Henley, Laura Downey","doi":"10.1371/journal.pone.0328016","DOIUrl":"10.1371/journal.pone.0328016","url":null,"abstract":"<p><strong>Background: </strong>People living with multiple long-term conditions (MLTC) are reported to have poorer quality of life, worse health outcomes, and higher health-related expenses compared to those with singular chronic health conditions. Living with MLTC is associated with a higher risk of care that is duplicate or unnecessary. Understanding and monitoring the quality of care (QoC) for those with MLTC is imperative to ensure that individuals complex care needs are met, maximising health and wellbeing and minimising harm and social/economic burden. There is paucity on what QoC means in the context of MLTC, which is likely different than a mere amalgamation of quality indicators of each contributory condition. There is even less understanding on how QoC can be measured in a way that meets the specific care priorities of individuals with MLTC. The aim of this review is to systematically map and analyse evidence on what QoC means for those affected by MLTC and the content and processes of any existing QoC indicators in MLTC, developed with patient or caregivers.</p><p><strong>Methods: </strong>We will systematically search for evidence following a Levac et al methodological scoping review process. All eligible studies published in English from 2000 onwards in the following databases will be included: MEDLINE, EMBASE, CINAHL, APA PsycINFO, Global Health and Health Management Information Consortium. Given expected study heterogeneity, a narrative synthesis is anticipated. Our Community Partner Advisory Group will assist in the identification and analysis of relevant evidence.</p><p><strong>Discussion: </strong>Current evidence shows variations in concepts and approaches when developing, implementing or validating QoC indicators, not always capturing patients' preferences nor the complex processes required in MLTC care. Clarifying concepts and synthesising evidence-based knowledge in this area will be the first step to inform the development of a project aiming to develop a set of patient-derived QoC indicators for use across multiple settings in the United Kingdom (UK) and beyond.</p><p><strong>Systematic review registration: </strong>Available on Open Science Framework on https://osf.io/gjr84.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 8","pages":"e0328016"},"PeriodicalIF":2.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144765248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}