PLoS ONE最新文献

{"title":"Flourishing at work: Psychometric properties of the Polish version of the Workplace PERMA-Profiler.","authors":"Paweł Fortuna, Agnieszka Czerw, Barbara Ostafińska-Molik, Agata Chudzicka-Czupała","doi":"10.1371/journal.pone.0319088","DOIUrl":"10.1371/journal.pone.0319088","url":null,"abstract":"<p><p>The main purpose of this study was to investigate the validity of the Polish version of the Workplace PERMA-Profiler (WPP). Our work was guided by Martin Seligman's perspective on positive psychology, emphasizing well-being as its central theme, flourishing as the gold standard for measuring well-being, and the ultimate goal of increasing flourishing. According to his PERMA model, flourishing encompasses five key elements: positive emotions, engagement, relationships, meaning, and accomplishment. The WPP is a tool specifically designed to measure this construct in the workplace context. Polish workers completed online surveys at the initial measurement (N = 1070). In addition, a group of working adults (N = 66) took part in a survey with a repeated measure diagnosing measurement stability. Flourishing, perceived stress, and work satisfaction were measured for comparisons of convergent validity, while zero-sum belief was measured for divergent validity. The reliability indices of the Polish version of the WPP met the minimum reliability requirements, and the Confirmatory Factor Analysis indicated that the five-factor model (contrasted to the single-factor model) achieved the desired goodness-of-fit properties. The WPP also demonstrated convergent validity through strong interrelationships with related constructs and strong stability. Obtaining satisfactory psychometric properties of the Polish version of the WPP enabled the conduction of additional type of exploratory analyzes focused on the relationship between workplace flourishing and the efforts aimed at building employee well-being undertaken by the organization where the respondents work. The study revealed a positive, moderate relationship between employees' flourishing and the evaluation of organizational practices for increasing employee well-being.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0319088"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating in vitro and in silico approaches for exploring antidiabetic potential of dimethyl and thiomethyl indolinone derivatives.","authors":"Kashif Ali, Ahmed A Elhenawy, Waqas Alam, Khalaf F Alsharif, Khalid J Alzahrani, Haroon Khan, Long Chiau Ming, Rahul G Ingle","doi":"10.1371/journal.pone.0319987","DOIUrl":"10.1371/journal.pone.0319987","url":null,"abstract":"<p><p>Diabetes mellitus (DM) is a metabolic disorder caused by insulin deficiency. It is a rapidly growing problem with immense social, economic and health related problems. The market available drugs for the management of DM possess several limitations and therefore the discovery of more effective agents is the need of time. The current study was designed to evaluate two oxindole derivatives: (E)-3-(2,4-Dimethylbenzylidene)-6-chloroindolin-2-one (compound 1), and (E)-3-(4-(Methylthio) benzylidene)-6-chloroindolin-2-one (compound 2) against α-amylase, protein glycation, and DPP-IV. In case of in vitro antidiabetic activities, compound 1 demonstrated significant inhibition at various concentrations with IC50 value of 32.917 µg/mL against α-amylase, 210.592 µg/mL against protein glycation and 31.28 µg/mL against DPP-IV. Similarly, when tested at various concentrations, compound 2 illustrated marked inhibition with IC50 value of 42.691 µg/mL on α- amylase, 341.551 µg/mL on protein glycation and 47.192 µg/mL against DPP-IV. Molecular docking studies identified the binding patterns of oxindoles in the active site of targeted protein and enzymes. Moreover, the docking analysis also showed the potent interaction of test compounds with the target sites against α-amylase, protein glycation and DPP-IV. In conclusion, both the compounds are significant inhibitors of α-amylase, protein glycation and DPP-IV in vitro assays with the support of molecular dynamic studies and therefore are potential candidates for further studies.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0319987"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genome-wide association studies on malaria in Sub-Saharan Africa: A scoping review.","authors":"Morine Akoth, John Odhiambo, Bernard Omolo","doi":"10.1371/journal.pone.0309268","DOIUrl":"10.1371/journal.pone.0309268","url":null,"abstract":"<p><strong>Background: </strong>Malaria remains one of the leading causes of death in Sub-Saharan Africa (SSA). The scoping review mapped evidence in research on existing studies on malaria genome-wide association studies (GWAS) in SSA.</p><p><strong>Methods: </strong>A scoping review was conducted to map existing studies in genome-wide association on malaria in SSA, with a review period between 1st January 2000 and 31st December 2024. The searches were made with the last search done in January 2025. The extracted data were analyzed using R software and SRplot. Relevant studies were identified through electronic searching of Google Scholar, Pubmed, Scopus, and Web of Science databases. Two independent reviewers followed the inclusion-exclusion criteria to extract relevant studies. Data from the studies were collected and synthesized using Excel and Zotero software.</p><p><strong>Results: </strong>We identified 89 studies for inclusion. Most of these studies (n = 42, [Formula: see text]) used a case-control study design, while the rest used cross-sectional, cohort, longitudinal, family-based, and experimental study designs. These studies were conducted between 2000 and 2024, with a noticeable increase in publications from 2012. Most studies were carried out in Kenya (n = 23), Gambia (n = 18), Cameroon (n = 15), and Tanzania (n = 9), primarily exploring genetic variants associated with malaria susceptibility, resistance, and severity.</p><p><strong>Conclusion: </strong>Many case-control studies in Kenya and Gambia reported genetic variants in malaria susceptibility, resistance, and severity. GWAS on malaria is scarce in SSA, and even fewer studies are model-based. Consequently, there is a pressing need for more genome-wide research on malaria in SSA.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0309268"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can laboratory-based XAFS compete with XRD and Mössbauer spectroscopy as a tool for quantitative species analysis? Critical evaluation using the example of a natural iron ore.","authors":"Sebastian Praetz, Christopher Schlesiger, Damian Alexander Motz, Stephen Klimke, Moritz Jahns, Christine Gottschalk, Lena Heinrich, Eva Maria Heppke, Wolfgang Malzer, Franz Renz, Carla Vogt, Birgit Kanngießer","doi":"10.1371/journal.pone.0323678","DOIUrl":"10.1371/journal.pone.0323678","url":null,"abstract":"<p><p>While X-ray diffraction (XRD) is a commonly used method for quantification analysis using Rietveld refinement and quantitative Mössbauer spectroscopy is sporadically used primarily for iron speciation, laboratory X-ray Absorption Fine Structure Spectroscopy (lab-XAFS) is rarely applied for the quantitative determination of sample compositions. With the recent developments of laboratory-based XAFS spectrometers, this method becomes more interesting for many applications as well as for quantification. The goal of this study is to compare quantitative lab-XAFS via Linear Combination Fitting (LCF) of reference spectra with XRD and Mössbauer spectroscopy. Iron species analysis with the focus on the determination of the mass ratio alpha-iron(III) oxide (α-Fe2O3)/iron(II, III) oxide (Fe3O4) was used as an example. The examinations were performed on synthetic α-Fe2O3/Fe3O4 model mixtures and, predominantly, on a natural iron ore sample mainly consisting of the minerals hematite and magnetite, thus, these two iron oxides. For the iron K-edge lab-XAFS measurements an X-ray tube-based spectrometer using the von Hamos geometry with Highly Annealed Pyrolytic Graphite (HAPG) mosaic crystal optic was used. The capabilities and challenges of each method are discussed. The quantitative model mixtures examinations by lab-XAFS show results and accuracies similar to those obtained by XRD and Mössbauer spectroscopy. However, while the quantitative results for the iron ore investigations by lab-XAFS are in good agreement (deviation of 2 percent points) with the XRD results, the composition determined by Mössbauer spectroscopy differs clearly from the lab-XAFS and XRD results. Furthermore, the Mössbauer spectroscopic examinations hint the presence of an additional iron oxide species affecting the quantification. Besides the still common challenges in identification, differentiation and quantification of different iron oxides, the results show that quantitative lab-XAFS can particularly compete with quantitative XRD when determining the species composition of one element. This makes lab-XAFS particularly well-suited for routine analytics.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0323678"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of care coordination interventions delivered to stroke survivors in low and middle-income countries: Systematic review and meta-analysis protocol.","authors":"Stephanopoulos Kofi Junior Osei, Anthony Danso-Appiah","doi":"10.1371/journal.pone.0324040","DOIUrl":"10.1371/journal.pone.0324040","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Stroke survivors have complex and long-term care needs requiring navigation of multiple care services and providers. Care coordination interventions provide wholistic care that meets the needs of the patient and improves their clinical outcomes and expectations. This systematic review will identify the key components of stroke care coordination interventions implemented in low and middle-income countries (LMICs) and assess their effectiveness on stroke outcomes such as motor recovery, cognitive function, mental health, stroke type and the role of stroke severity, type, and the nature of the interventions in influencing these outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Electronic databases, trial registries and non-database sources will be searched for published and unpublished studies. PubMed, LILACS, CINAHL via EBSCOhost, Scopus, Web of Science Core Collection, Cochrane CENTRAL and Google Scholar will be searched from 2000 to 31st May 2025, without language restriction. Trial registries including the WHO International Clinical Trials Registry Platform (ICTRP) and Clinicaltrials.gov will also be searched. Grey literature including dissertations, preprint repositories and conference proceedings will be searched. The key search terms include \"stroke\", \"care integration\", \"continuity of care\", \"information exchange\", \"patient-centred care\", \"multidisciplinary care\", \"case management\" and \"low and middle-income countries\", together with their alternative terms and synonyms, singular and plural forms and American and British spelling. Hand search of references of relevant studies will be carried out and experts in the field of stroke care coordination interventions will be contacted for their knowledge about any study missed by our searches. The studies will be collated in Rayyan and duplicates removed. Study selection will be done using a study selection flow chart developed from the pre-specified eligibility criteria defined by the PICOS elements (P ─ patient, I ─ intervention, C ─ comparator, O ─ outcomes and S ─study). Quality in the included studies will be assessed for risk of bias using the Cochrane Risk of Bias tool (version 2) for Randomized Controlled Trials (RoB 2) and ROBINS-I for Non-randomized Studies of Intervention. Data will be extracted using a pre-tested data extraction form developed from Microsoft Excel. Study selection, data extraction and risk of bias assessment will be conducted independently by two reviewers (SKJO and ADA). Disagreements between the reviewers will be resolved through discussion. Risk ratio (RR) will be used as the effect measure for binary/dichotomous outcomes. For continuous outcomes mean difference (MD) with standard deviation (SD) or standardized mean difference (SMD) for outcomes measured on different instruments or scales will be used as effect measures for expressing effectiveness of care coordination interventions. Random-effects meta-analyses will be employed to pool studi","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0324040"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the characteristics of cancer-centred civil society organisations in Chile: A qualitative study.","authors":"Antonia Roberts, Francisca Vezzani, Báltica Cabieses, Alexandra Obach, Carla Campaña, Manuel A Espinoza","doi":"10.1371/journal.pone.0315589","DOIUrl":"10.1371/journal.pone.0315589","url":null,"abstract":"<p><strong>Background: </strong>In Chile, civil society organisations in health have been historically active in population health and specifically in cancer; they have had an important role in addressing patients' and families' necessities. Although they occupy a central role, there is no clarity about who they are, how they are organised, the goals that guide their performance and how they materialize social participation in health. Based on that, this study aimed to explore the characteristics of civil society organisations that work in cancer in Chile and to identify the networks they build with other actors to achieve their goals.</p><p><strong>Materials and methods: </strong>Qualitative case study using semi-structured online interviews with organisation representatives, politicians, decision-makers and academics related to cancer in Chile. Content analysis was performed, admitting emerging categories from the participants' narratives.</p><p><strong>Results: </strong>Three main profiles of organisations were identified: (i) Long-established organisations focused on influencing public policy and decision-making in cancer, (ii) Growing organisations focused on informing and supporting families and patients, (iii) Newly established organisations focused on patient well-being, such as sports activities. Relationships between groups and other actors involve perceived benefits like the growth of the organisations and funding for activities. However, perceived barriers and inequities are also identified, mainly lack of financial resources, competition between organisations and insufficient information.</p><p><strong>Discussion: </strong>The objectives of civil society organisations in cancer are diverse and reflect multiple ways of practising social participation in health. Tensions generate unequal participation and missed opportunities to promote public health in cancer in Chile. The study highlights the importance of recognising cancer social organisations as essential actors in public health. It is crucial to involve them in formulating and implementing comprehensive responses to maximise the opportunities for progress in this field.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0315589"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and predictors of cardiovascular disease mortality and all-cause mortality in patients with type II diabetes with peripheral arterial disease.","authors":"Amaraporn Rerkasem, Ampica Mangklabruks, Supawan Buranapin, Kiran Sony, Nimit Inpankaew, Rath Rerkasem, Sasinat Pongtam, Kochaphan Phirom, Kittipan Rerkasem","doi":"10.1371/journal.pone.0322502","DOIUrl":"10.1371/journal.pone.0322502","url":null,"abstract":"<p><strong>Objective: </strong>This cohort study estimated the incidence and predictors of cardiovascular disease (CVD) and all-cause mortality among patients with type 2 diabetes mellitus (T2DM) and various stages of peripheral arterial disease (PAD) at the largest tertiary referral hospitals in upper-northern Thailand.</p><p><strong>Methods: </strong>This study recruited 278 T2DM and PAD patients for a 7-year cohort study. These patients completed health questionnaires and underwent physical examinations including ankle-brachial index measurements and clinical assessment to determine PAD severity. Mortality endpoints were determined using hospital death registers and national death records. The Cox proportional hazards and subdistribution hazard models were used to estimate PAD's effect on mortality, quantifying the association with hazard ratios (HR) and subdistribution hazard ratios (SHR).</p><p><strong>Results: </strong>PAD patients were categorized into three subgroups. Over seven years, the cumulative all-cause mortality rate was 36%, or 6.4 deaths per 100 person-years. Multivariable analysis revealed critical limb ischemia (CLI) patients had significantly higher risks of all-cause (HR 5.26, 95%CI 3.10-8.94) and CVD mortality (SHR 6.20, 95%CI 3.20-12.03) compared to their asymptomatic peers. No statistically significant differences in non-CVD mortality were noted across PAD subgroups.</p><p><strong>Conclusion: </strong>CLI, chronic kidney disease, and underweight (body mass index < 18.5 kg/m2) emerged as independent mortality predictors. Conversely, asymptomatic PAD patients had a similar overall mortality risk as those with intermittent claudication. These findings highlight the need for risk stratification and patient empowerment to optimize management of these complex conditions.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0322502"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of perceived family state and functioning among individuals with depression and general population in Southern Thailand.","authors":"Jarurin Pitanupong, Kwanpond Traivaranon, Napakkawat Buathong","doi":"10.1371/journal.pone.0323866","DOIUrl":"10.1371/journal.pone.0323866","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine perceived family functioning among individuals with depression, then compare these perceptions with those of the general population.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted among individuals with depression at Songklanagarind Hospital and individuals from the general population; from May to July 2024. Participants completed three questionnaires: 1) Personal and demographic inquiry, 2) the Family State and Functioning Assessment Scale (FSFAS-25), and 3) the Patient Health Questionnaire (PHQ-9). Data analysis involved descriptive statistics, Chi-square or Fisher's exact test, Wilcoxon rank sum test and Student's t-test.</p><p><strong>Results: </strong>The study compared 41 individuals with depression with 41 from the general population; revealing significant differences in family functioning scores. The depression group reported lower median family functioning scores (76 [IQR 64-84]) compared with the general population (87 [IQR 77-93]). Fewer individuals in the depression group reported high total family functioning scores (56.1% vs. 82.9%, p = 0.016). They also showed lower percentages in family support (61.0% vs. 95.1%, p < 0.001) and discipline dimensions (46.3% vs. 78.0%, p = 0.006). Furthermore, those with residual depression symptoms (PHQ-9 having a score of nine or higher) showed significant differences in family support (37.5% vs. 76.0%, p = 0.033) and emotional status (18.8% vs. 60.0%, p = 0.023) compared with those without residual depression symptoms.</p><p><strong>Conclusion: </strong>Individuals with depression demonstrated lower levels of family functioning compared with the general population. Acknowledging and addressing the influence of family dynamics on the development and persistence of the disorder may be essential for improving treatment outcomes. Integrating these factors into person-centered mental health interventions can lead to more comprehensive, individualized, and effective care.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0323866"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the association between weight-adjusted waist index and migraine: A cross-sectional study.","authors":"Shulong Liu, Jiangting Li, Guobo Xie","doi":"10.1371/journal.pone.0323087","DOIUrl":"10.1371/journal.pone.0323087","url":null,"abstract":"<p><strong>Objective: </strong>This study examines how weight-adjusted waist index (WWI) correlates with the occurrence of migraine in U.S. adults.</p><p><strong>Background: </strong>Being overweight significantly increases the likelihood of experiencing migraines; nonetheless, conventional metrics like waist circumference (WC) and body mass index (BMI) might not completely capture the level of migraine risk tied to obesity. WWI integrates the strengths of WC while minimizing its correlation with BMI, which might make it a more accurate indicator of central obesity-related migraine susceptibility.</p><p><strong>Methods: </strong>This study performed a cross-sectional analysis using data from 9,688 participants obtained from the National Health and Nutrition Examination Survey (NHANES), covering the years 1999-2004. Migraine occurrence was evaluated through questionnaires, and participants' WWI was computed. Weighted multivariable logistic regression models were used to examine the association between WWI and migraines. Restricted cubic splines (RCS) were applied to evaluate the dose-response relationship between WWI and migraines. Furthermore, interaction tests and subgroup analyses were executed. The receiver operating characteristic (ROC) curve, paired with DeLong et al.'s test, was employed to compare the predictive power of WWI, BMI, and WC for migraines.</p><p><strong>Results: </strong>The overall prevalence of migraines was found to be 21.50% (weighted population: 31,888,075 out of 148,278,824). In Model 3, the link between WWI and migraines in women showed no statistical significance (OR = 0.94, 95% CI: 0.82-1.07). In this model, each unit increase in WWI among men was linked to a 22% higher risk of migraines (OR = 1.22, 95% CI: 1.05-1.42). When stratified by quintiles, individuals in the third quintile (Q3) displayed a 69% higher likelihood of experiencing migraines compared to those in the first quintile (Q1) (OR = 1.69, 95% CI: 1.19-2.40), with a significant inflection point observed at 10.95 cm/√kg. Significant interactions were noted among various age groups (p for interaction = 0.018). WWI demonstrated a stronger predictive capability for migraine compared to BMI and WC.</p><p><strong>Conclusion: </strong>A U-shaped positive correlation of WWI with migraines was observerd among adult males in the U.S., while no significant correlation was found in females. Within the context of BMI and WC, WWI exhibited a superior predictive capacity for migraines.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0323087"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of serological testing implementation on tick-borne encephalitis detection in Poland.","authors":"Joanna Zajkowska, Elżbieta Waluk, Renata Świerzbińska, Justyna Dunaj, Olga Zajkowska, Dominik Wawrzuta, Jolanta Niścigorska-Olsen, Marek Matukiewicz, Barbara Oczko-Grzesik, Daniel Veltze, Katarzyna Bernacka-Andrzejewska, Katarzyna Burchart-Adamczyk, Ewa Dutkiewicz, Jadwiga Maciukajć, Krystyna Konieczny, Danuta Malcher-Bober, Dorota Dybowska, Małgorzata Hapyn-Rocha, Monika Marsik-Styrkosz, Grzegorz Kmak, Monika Bociąga-Jasik, Magdalena Byś-Chrzanowska, Iwona Paradowska-Stankiewicz","doi":"10.1371/journal.pone.0323022","DOIUrl":"10.1371/journal.pone.0323022","url":null,"abstract":"<p><strong>Introduction: </strong>Tick-borne encephalitis virus (TBEV) infections remain underreported in Poland, leading to inadequate public awareness of the potential severity of the disease and its preventive measures.</p><p><strong>Aim: </strong>This study aims to assess the incidence of tick-borne encephalitis (TBE) in non-endemic regions of Poland by analyzing serum or cerebrospinal fluid (CSF) samples from patients with neuroinfections of unknown origin.</p><p><strong>Materials and methods: </strong>In this study, 29 departments specializing in neuroinfections were involved. Hospitals were chosen from regions classified as non-endemic with limited TBE reporting. Patients treated between April 1, and December 31, who had neuroinfections of unknown origin, were enrolled. Their CSF or serum samples underwent serological diagnosis of TBE using the Virotech ELISA kit at the Immunoserology Laboratory of the Medical University of Białystok. In addition, we used questionnaires to collect clinical and epidemiological data from patients.</p><p><strong>Results: </strong>Among 766 patients, 124 exhibited serum or CSF antibodies against TBEV. None of them were vaccinated against TBE. The highest positivity rates were observed in Małopolskie (31%), Świętokrzyskie (24%), and Dolnośląskie (22%) voivodeships. In contrast, the Kujawsko-Pomorskie (2%), Pomorskie (3%), and Zachodniopomorskie (7.5%) voivodeships showed the lowest ratios. All patients reported their place of residence as a potential source of infection, some also mentioning outdoor activities, travel, work, and unpasteurized dairy consumption.</p><p><strong>Conclusions: </strong>This study reveals a notable incidence of TBE infections in patients with nonspecific neuroinfections residing in regions historically seen as non-endemic. These findings emphasize the need for improved reporting and educational initiatives to raise awareness of the risk of TBE.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 5","pages":"e0323022"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}