PLoS ONE最新文献

{"title":"Correction: Endurance-trained subjects and sedentary controls increase ventricular contractility and efficiency during exercise: Feasibility of hemodynamics assessed by non-invasive pressure-volume loops.","authors":"Björn Östenson, Ellen Ostenfeld, Jonathan Edlund, Einar Heiberg, Håkan Arheden, Katarina Steding-Ehrenborg","doi":"10.1371/journal.pone.0321568","DOIUrl":"https://doi.org/10.1371/journal.pone.0321568","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0285592.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0321568"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferences and willingness for starting daily, on-demand, and long-acting injectable HIV pre-exposure prophylaxis among transfeminine persons in the US, 2022-2023.","authors":"Duygu Islek, Travis Sanchez, Stefan Baral, Carolyn Brown, Joanna A Caldwell, Jennifer L Glick, Danielle Friedman Nestadt, Jeb Jones, Iaah L Lucas, Supriya Sarkar, Annemiek de Ruiter, Patrick S Sullivan, Mariah Valentine-Graves, Savannah Winter, Vani Vannappagari","doi":"10.1371/journal.pone.0320961","DOIUrl":"https://doi.org/10.1371/journal.pone.0320961","url":null,"abstract":"<p><strong>Background: </strong>There remains limited information concerning US transfeminine persons preferences across varying PrEP options. We examined PrEP option willingness, preferences, and associated factors among a US nationwide sample of transfeminine persons.</p><p><strong>Methods: </strong>Sexually active transfeminine persons age 15 + were recruited online between June 2022-October 2023 through social media advertisements. Transfeminine persons not diagnosed with HIV were asked about willingness to initiate, and ranked preference, of three PrEP options- daily oral (DO), on-demand, and long-acting injectable (LA-PrEP). Log-binomial models were used to examine PrEP modality willingness and associated sociodemographic and behavioral characteristics.</p><p><strong>Results: </strong>Among 2657 transfeminine persons not currently using PrEP, 51% reported willingness to start at least one PrEP option. The highest willingness was reported for on-demand PrEP (42.6%), followed by DO (38.1%) and LA PrEP (27.1%). LA PrEP was ranked the most preferred PrEP option among transfeminine persons who reported willingness to start multiple PrEP options (43%, 277/651). Willingness to start on-demand PrEP was higher among participants who were 15-24 years, resided in the South, did not have health insurance, had more than one sex partners and reported prior awareness of on-demand PrEP. Willingness to use DO and LA PrEP was higher among those who had both private and public insurance, reported condomless anal sex, had more than one sex partners and had used non-injection illicit drugs. Additional factors for DO and LA PrEP willingness was residing in the South and prior awareness of LA PrEP, respectively.</p><p><strong>Conclusions: </strong>Among transfeminine persons, the highest willingness was reported for on-demand PrEP; and LA PrEP was ranked the most preferred option among those who reported willingness to try multiple options. Offering a variety of PrEP options, informed by an understanding of individual preferences and socio-demographic and behavioral differences, can increase overall PrEP uptake and help meet diverse needs of the transfeminine community.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0320961"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Historical precipitation and flood damage in Japan: Functional data analysis and evaluation of models.","authors":"Atsushi Wakai, Yasuaki Hijioka, Masayuki Yokozawa, Manabu Watanabe, Gen Sakurai","doi":"10.1371/journal.pone.0321855","DOIUrl":"https://doi.org/10.1371/journal.pone.0321855","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0318335.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0321855"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Sound garden: How snakes respond to airborne and groundborne sounds.","authors":"Christina N Zdenek, Timothy Staples, Chris Hay, Lachlan A Bourke, Damian Candusso","doi":"10.1371/journal.pone.0321508","DOIUrl":"https://doi.org/10.1371/journal.pone.0321508","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0281285.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0321508"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining isokinetic knee peak torque and time to peak torque as predictors of vertical jump height in division I men's basketball players.","authors":"Caroline Westwood, Arakua Welbeck, Carolyn Killelea, Peter Howard, Mallory Faherty, Daniel Le, Ryan Zerega, Charles R Reiter, Timothy C Sell","doi":"10.1371/journal.pone.0303701","DOIUrl":"https://doi.org/10.1371/journal.pone.0303701","url":null,"abstract":"<p><p>The vertical jump (VJ) is one of the most important movements for basketball athletes and therefore determining modifiable predictors of the VJ would aid substantially in crafting more effective training regimens. The purpose of this study was to determine if isokinetic quadriceps strength and torque predict VJ height and which characteristics and testing speed is the strongest predictor of VJ height. Fifteen subjects (age: 18.5 ± 1.0 years, height: 195.9 ± 6.9 cm, weight: 96.2 ± 13.7 kg) from a single Division I men's basketball team were recruited for this study. All participants performed a standing vertical jump with arm-swing to assess their maximum VJ height. Participants also completed an isokinetic knee extension strength protocol that included testing at multiple speeds. Pearson and Spearman tests found no significant correlation between jump height and peak torque at any of the speeds. Regression analysis showed a statistically significant relationship between time to peak torque at 300°/s and VJ height (R2 =  0.23, p =  0.04). These findings suggest that in a population of elite basketball players, the knee's ability to rapidly generate torque likely plays a greater role in VJ performance than its ability to generate high magnitude of torque. This presents a potential benefit of explosive training regimens such as plyometrics for maximization of jump performance.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0303701"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the prevalence of chronic diseases and health status among international Hajj pilgrims.","authors":"Osama Samarkandi, Fahad Alamri, Ghadah Alsaleh, Lamees Al Abdullatif, Jumanah Alhazmi, Mohammed Basnawi, Waleed Alazmy, Anas Khan","doi":"10.1371/journal.pone.0317555","DOIUrl":"https://doi.org/10.1371/journal.pone.0317555","url":null,"abstract":"<p><strong>Background and aims: </strong>Pilgrims with pre-existing Chronic Diseases are at high risk of physical stress that can lead to unexpected health outcomes, including multiple visits to the hospital, organ failure, or even death. In addition, the risk of mortality related to Chronic Diseases increases during mass gatherings due to these same reasons. Therefore, this study aims to evaluate the Prevalence of Chronic Diseases and clinical symptoms among pilgrims during Hajj 2024 in Saudi Arabia.</p><p><strong>Methods: </strong>During the 2024 Hajj rituals, cross-sectional questionnaires were administered to pilgrims at the Jeddah International Airport. The questionnaire contained questions on sociodemographic information, the presence of Chronic Diseases, types of Chronic Diseases, and clinical symptoms.</p><p><strong>Results: </strong>A total of 1920 pilgrims were included in the study, with a mean age of 52.03 ± 13.43 and a median of 53 years. Among those, 49.4% were males. The prevalence of Chronic Diseases (CDs) was 36.3% (n = 697). Among those, 16% (n = 308) of them reported hypertension, followed by diabetes 11.6% (n = 222), asthma (4%, n = 76), and cardiovascular diseases (3.4% n = 65). The most common symptoms associated with Chronic Diseases were cough (36.5%, n = 700), followed by fever (21.8%, n = 419), and sore throat (21.2%, n = 407). The presence of diabetes was significantly associated with gender (p = 0.019), while hypertension was more common among male pilgrims (n = 829) compared to female pilgrims (n = 783) (p = 001). Furthermore, the presence of coughing was significantly associated with the age and educational level of the pilgrims (p = 0.001). On the other hand, headaches were more common among females compared to male pilgrims (p = 0.001).</p><p><strong>Conclusion: </strong>A considerable number of pilgrims suffer from Chronic Diseases, with hypertension being most common. Further interventions, such as education and management before Hajj, are recommended.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0317555"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction of total flavonoids from Chaenomeles speciosa (Sweet) Nakai and its antioxidant and lipoxygenase inhibition effects.","authors":"Wenqing Pei, Yuting Sun, Juan Li, Yupei Zhang, Chenkang Jian, Feng Lu, Ali Tao, Qizhao Li","doi":"10.1371/journal.pone.0320582","DOIUrl":"https://doi.org/10.1371/journal.pone.0320582","url":null,"abstract":"<p><p>Ultrasound-assisted extraction technology was utilized to extract total flavonoids from Chaenomeles speciosa (Sweet) Nakai, and response surface methodology was employed to optimize the extraction process. The anti-oxidant and lipoxygenase inhibitory activities were evaluated, along with an analysis of the type of inhibition. The results revealed that the optimal extraction conditions for total flavonoids from Chaenomeles speciosa (Sweet) Nakai were as follows: an ethanol concentration of 62%, a liquid-to-solid ratio of 15:1 mL/g, an ultrasonic temperature of 68°C, and an ultrasonic time of 40 min, resulting in a total flavonoid extraction rate of 10.18%. Antioxidant assays demonstrated that the Chaenomeles speciosa (Sweet) Nakai extract exhibited significant radical scavenging activities against 1,1-diphenyl-2-picrylhydrazyl radicals, 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid ammonium salt) radicals, and hydroxyl radicals, with IC50 values of 582 µg/mL, 538 µg/mL, and 1709 µg/mL, respectively. Furthermore, enzyme inhibition assays indicated that the Chaenomeles speciosa (Sweet) Nakai extract possesses notable inhibitory activity against lipoxygenase, with an IC50 value of 2658 µg/mL. This inhibition is mediated through a mixed reversible inhibition mechanism.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0320582"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Active surveillance for Theileria orientalis and the invasive Asian longhorned tick (Haemaphysalis longicornis) in three Missouri beef herds.","authors":"Rosalie A Ierardi, Savannah M Chance, Celeste Morris, Jacqueline Nunnelley, Solomon O Odemuyiwa, Angela B Royal, Loren Schultz, Zhenyu Shen, Jordyn Young, Ram K Raghavan","doi":"10.1371/journal.pone.0319327","DOIUrl":"https://doi.org/10.1371/journal.pone.0319327","url":null,"abstract":"<p><p>Theileria orientalis is a protozoan hemoparasite of cattle vectored by the rapidly emerging invasive Asian longhorned tick (Haemaphysalis longicornis). Theileria-associated bovine anemia (TABA) is easily mistaken for bovine anaplasmosis, which can lead to delayed diagnosis in areas where bovine anaplasmosis is endemic and TABA is newly emerging. Our objective was to surveil for infestation of cattle by H. longicornis and infection with T. orientalis on three Missouri cow-calf operations in counties where H. longicornis is known to be established. A total of 147 apparently healthy adult cows from 3 herds were inspected for ticks. Whole blood was collected for T. orientalis and Anaplasma marginale quantitative PCR and was also used for immediate preparation of blood smears and measurement of packed cell volumes. A total of 527 ticks were collected from the cows and taxonomically identified to the species level. Eighteen H. longicornis, including 9 adult females and 9 nymphs, were collected from 16 cows (Farm A, 2 cows; Farm B, 4 cows; Farm C, 10 cows). Intraerythrocytic T. orientalis organisms were presumptively identified on blood smears from 10 cows. Quantitative PCR screening of blood samples with primers designed to amplify all T. orientalis genotypes detected 11 positive samples (Farm A, 7 cows; Farm B, 3 cows; Farm C, 1 cow). Positive samples were re-tested with probes specific for the Ikeda, Chitose, and Buffeli genotypes, which detected the Chitose genotype in 10 samples and the Ikeda genotype in 1 sample. Detection of T. orientalis with concurrent infestation of cows by H. longicornis within these 3 herds, along with collection of H. longicornis from vegetation on the premises, supports local tick-borne transmission of this emerging pathogen.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0319327"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum iron status with MASLD and liver fibrosis.","authors":"Wenying Guo, Ting Weng, Yufei Song","doi":"10.1371/journal.pone.0319057","DOIUrl":"https://doi.org/10.1371/journal.pone.0319057","url":null,"abstract":"<p><strong>Background: </strong>The MASLD proposal updates and supplements the previous definition of NAFLD, making it more suitable for addressing the current understanding of chronic liver diseases. This study aims to investigate the potential association between serum iron status and the occurrence of MASLD and liver fibrosis.</p><p><strong>Methods: </strong>An in-depth analysis was conducted using the 2017-2020 NHANES data. To assess the relationship between serum iron status and the prevalence of MASLD and liver fibrosis, we performed comprehensive data analysis. This approach accounts for multiple variables, enhancing the robustness and reliability of our results by reducing potential confounding factors.</p><p><strong>Results: </strong>Our application of linear regression models provided significant insights through a comprehensive data analysis. Elevated serum ferritin, TIBC, and UIBC showed a distinct positive correlation with CAP, while only serum ferritin was positively correlated with LSM. Multivariate logistic regression analysis revealed that elevated levels of serum ferritin, TIBC, and UIBC were significantly associated with the occurrence of MASLD, whereas only serum ferritin showed a similar association with the occurrence of liver fibrosis.</p><p><strong>Conclusion: </strong>This study highlights the significant positive correlation between elevated levels of serum ferritin, TIBC, and UIBC with CAP and the prevalence of MASLD. A similar relationship was observed between serum ferritin with LSM and the prevalence of liver fibrosis.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0319057"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive study on characterization of biosynthesized copper-oxide nanoparticles, their capabilities as anticancer and antibacterial agents, and predicting optimal docking poses into the cavity of S. aureus DHFR.","authors":"Ehab S Gad, Salem S Salem, Samy Selim, Mohammed S Almuhayawi, Mohammed H Alruhaili, Soad K Al Jaouni, Amna A Saddiq, Medhat E Owda","doi":"10.1371/journal.pone.0319791","DOIUrl":"https://doi.org/10.1371/journal.pone.0319791","url":null,"abstract":"<p><p>The eco-friendly method of producing copperـoxide nanoparticles through the use of okra fruit extract is a simple, economical, rapid, and sustainable technique. The resultant copperـoxide nanoparticles (CuO NP) were analyzed with several analytical methods, such as UV-vis spectroscopy, FourierـTransform Infrared Spectroscopy (FT-IR), and X-Ray Diffraction (XRD), Zeta potential, TransmissionـElectron Microscopy (TEM) and EnergyـDispersive X-ray (EDX) analysis. The CuO NP exhibited a maximum absorbance at 381 nm. The formation of CuO NP was further confirmed by characteristic bands observed at 534 and 588 cm-1. The monoclinic structure of the CuO NP was identified with prominent peaks detected at 2θ values of 32.47°, 35.43°, 38.64°, 48.68°, 53.38°, 58.14°, 61.39°, 66.11°, 67.82°, 72.27°, and 74.96°. The overall findings indicate that the nanoparticles had an average diameter in the approximate range of 10 to 30 nm based on the TEM analysis. The cytotoxicity study, conducted on Human Fibroblast normal HFB4 cell lines, indicated that the halfـmaximal inhibitory concentration (IC50) dose was 236.34 μg/mL. An IC50 dose of 109.46 μg/mL was found in antitumor effect studies using breast adenocarcinoma Mcf- 7 cell lines, revealing a good level of safety for CuO NP. According to the antibacterial study, Staphylococcus aureus and Bacillus cereus had inhibition zone diameters (IZDs) of 29.5 ± 0.7 mm and 24.6 ± 1.2 mm, respectively, making them the most vulnerable bacteria to CuO NP. In contrast, P. aeruginosa was the least sensitive strain, with a minimum IZD of 15 ± 1.6 mm. Compared to gram-negative infections, the CuO NPs were found to have a significantly higher antibacterial effectiveness versus Gram -positive pathogens. Molecular docking against dihydrofolate reductase (DHFR) of Staphylococcus aureus (PDB ID: 6P9Z) illustrated that the CuO NP was partially interlocked with the active site of 6P9Z by the fitting energy value of -44.93 kcal/mol through five classical hydrogen bonds with Ala7, Gln9, Thr46, Ser49, and Phe92. The last one is also generated by the marketing antifolate agent methotrexate (MTX), adding some MTX-like character to the CuO NP inhibitor.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0319791"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}