PLoS ONE最新文献

{"title":"Computational and In silico study of novel fungicides against combating root rot, gray mold, fusarium wilt, and cereal rust.","authors":"Mollah Naimuzzaman, Md Mahabub Hasan, Ajoy Kumer, Abu Yousuf Hossin, Mohammad Harun-Ur-Rashid, Swapan Kumar Roy, Abu Noman Faruq Ahmmed, Jamal Uddin","doi":"10.1371/journal.pone.0316606","DOIUrl":"10.1371/journal.pone.0316606","url":null,"abstract":"<p><p>The exploration of potential candidates for fungicides against four fungal proteins that cause some vital plant diseases, namely Phytophthora capsici, Botrytis cinerea, Fusarium oxysporum f. sp. lycopersici, and Puccinia graminis f. sp. tritici, was conducted using in silico, molecular docking simulations, and molecular dynamic (MD) simulation for selecting the nature of binding affinity with actives sites of proteins. First of all, the DFT was employed to optimize the molecular geometry, and get the prepared optimized ligand. From the DFT data, the chemical descriptors were calculated. Next, two docking tools, such as AutoDock by PyRx and Molecular Docking by Glide from the Schrödinger suite, were used to convey the docking score, and ligand protein interactions against four main proteases, for instance 7VEM, 8H6Q, 8EBB, and 7XDS having name of pathogens: Phytophthora capsici, Botrytis cinerea, Fusarium oxysporum f. sp. lycopersici, and Puccinia graminis f. sp. tritici, respectively. In case of auto dock from PyRx, the fungicides L01, L03, L04, L13, L14, L17, L18, and L19 demonstrated significantly higher affinities for binding to the four fungal pathogens. Surprisingly, it is conveyed that the L03 illustrated the highest binding score against three of 7VEM, 8EBB, and 7XDS proteins and L09 is highest for 8H6Q. However, MD was performed to check the validation and calculation the docking procedure and stability of the protein ligand docked complex accounting of RMSD, RMSF, SASA, Radius of gyration (Rg), Protein secondary structure elements (SSE), Ramachandran plot which confirm that the stability of docked complex is so high, and number of calculating the hydrogen bonds is more than good enough, as a result it is concluded the docking procedure is valid. Finally, Difenoconazole (L03) has been considered as the most promising antifungal drug evaluated from the studies.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0316606"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The combined impacts of toxic drug use and the 2021 Heat Dome in Canada: A thematic analysis of online news media articles.","authors":"Emily J Tetzlaff, Nicholas Goulet, Melissa Gorman, Glen P Kenny","doi":"10.1371/journal.pone.0318229","DOIUrl":"10.1371/journal.pone.0318229","url":null,"abstract":"<p><strong>Introduction: </strong>During the summer of 2021, western Canada experienced a historic and deadly extreme heat event. Simultaneously, toxic drug use and overdoses related to high-risk use of opioids and polysubstance use continued to rise across the country. However, the combined impacts of these intersecting public health crises remain poorly understood as relevant data sources are limited in Canada.</p><p><strong>Methods: </strong>We explored news media articles (n = 86, 3%) discussing toxic drug use, overdose-related deaths and the 2021 Heat Dome which were identified in a systematic review of Canadian online news media (e.g., newspaper articles, radio broadcasts) from five subscription news databases and an extensive grey literature search (n = 2909). The analyzed articles were published before, during and after the 2021 Heat Dome, and were qualitatively coded and thematically analyzed in NVivo to identify patterns of meaning across the dataset.</p><p><strong>Results: </strong>Four main themes were identified within our media-based analysis: (I) the reported impact of toxic drug use on human thermoregulation and behavioural adaptation; (II) the reported demand of intersecting crises on the health system; (III) barriers and stigma reported to influence an individual's access to or use of heat mitigation behaviours and services; and (IV) the reported impact of extreme heat on the public health response to drug poisoning emergencies.</p><p><strong>Conclusion: </strong>With increasing temperature extremes and a rising tide of toxic drug use and overdoses, our findings illustrate that there is a need for further research to better understand the combined impacts when toxic drug use, overdose-related deaths, and extreme heat coincide.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0318229"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of sexual health literacy on sexual function mediated by sexual satisfaction and sexual self-efficacy: Structural equation modeling approach.","authors":"Mojdeh Banaei, Saeed Hosseini, Shiva Alizadeh, Nasibeh Roozbeh, Behnaz Jahanshahloo, Elham Ghasemi, Vida Ghasemi","doi":"10.1371/journal.pone.0318002","DOIUrl":"10.1371/journal.pone.0318002","url":null,"abstract":"<p><p>Existing literature suggests that sexual health literacy may influence sexual function by enhancing sexual satisfaction and other dimensions of sexual health. This study aimed to investigate the effect of sexual health literacy on sexual function, mediated by sexual satisfaction and sexual self-efficacy, among Iranian women. A cross-sectional study was conducted using structural equation modeling (SEM) with 431 eligible women of childbearing age recruited from health centers in Asadabad city, Hamadan, Iran, from 2023 to 2024 through convenience sampling method. Data were collected using several tools: demographic and obstetric information form, sexual health literacy for adults (SHELA) questionnaire, female sexual function index (FSFI), sexual self-efficacy questionnaire (SSE), and the inventory of sexual satisfaction (ISS). Structural equation modeling was performed using IBM SPSS AMOS version 23. The mean ± SD age of the participants was 31.92 ± 7.24 years. The direct effects of sexual health literacy, sexual self-efficacy, and sexual satisfaction on sexual function were significant (P < 0.001). The indirect effect of sexual health literacy on sexual function, mediated by sexual satisfaction, was also significant (P < 0.001). Overall, the total effect (direct and indirect) of sexual health literacy on sexual function was deemed appropriate, and the proposed conceptual model demonstrated a good fit with the data (χ2/df = 3.35; CFI = 0.966; IFI = 0.967; GFI = 0.951; AGFI = 0.904; RMSEA = 0.070). Based on these findings, sexual health literacy has both direct and indirect effects (mediated by sexual satisfaction) on sexual function. These results may guide professionals in the field of marital relationships to recognize the importance of sexual health literacy and to develop educational or counseling interventions aimed at improving sexual health literacy, ultimately enhancing sexual function.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0318002"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining application rates of FYM and pressmud to improve soil health properties in salt degraded soils.","authors":"M L Dotaniya, M D Meena, R L Choudhary, M K Meena, V D Meena, H V Singh, R S Jat, R K Doutaniya, Kuldeep Kumar, Harpreet Singh, P K Rai","doi":"10.1371/journal.pone.0317463","DOIUrl":"10.1371/journal.pone.0317463","url":null,"abstract":"<p><p>Improving food grain production by enhancing plant nutrient availability is critical for meeting future production. In this line, degraded soils may have the potential to meet the food demand of future population. However, the key challenge is excessive concentration of salts. It adversely mediates the soil fertility parameters, physical properties and soil enzymatic activities. Addition of organic substances, such as farm yard manure (FYM) and pressmud (PM), may improve soil health parameters. An incubation experiment was conducted with graded application of FYM (0, 2.5, 5 and 10 t/ha) and PM (0, 2.5, 5 and 10 t/ha) to monitor the nutrient release pattern of FYM and PM; and its effect on soil physico-chemical properties and soil enzymatic activities. The results showed that soil pH and EC were reduced after the one year incubation period. It was also observed that available plant nutrients like N, P, K, S and soil enzymatic activities reported highest in treatment FYM and PM (each applied 10 t/ha) over control. The findings of this study suggested that organic amendments can improve soil fertility, mitigate salt ion toxicity, and enhance food production potential, particularly in arid and semi-arid soils.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0317463"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a mental health-related structural stigma measurement framework in the healthcare system setting: A modified Delphi study.","authors":"Dristy Gurung, Bhawana Subedi, Brandon A Kohrt, Syed Shabab Wahid, Sauharda Rai, Graham Thornicroft, Petra C Gronholm","doi":"10.1371/journal.pone.0316999","DOIUrl":"10.1371/journal.pone.0316999","url":null,"abstract":"<p><strong>Introduction: </strong>There is a worldwide dearth in literature on the nature, causes, and consequences of structural stigma in mental healthcare. This study aimed to address this gap by exploring key components for measuring structural stigma in healthcare system settings.</p><p><strong>Methods: </strong>We used a modified Delphi method consisting of 3 rounds with global experts (stigma researchers, persons with lived experiences of mental health conditions (PWLEs), and policymakers). In the first round, indicators identified through a literature review (n = 39 studies) were appraised through expert consultation workshops with 22 panellists, including 54.5% women, 41% PWLEs, and 68.2% from low-and-middle income countries (LMICs). Round 2 (n = 53 panellists; 51% women, 8.3% PWLEs, and 56.6% from LMICs) involved ranking indicators through an online survey, and Round 3 (n = 58 panellists; 46% women, 21.7% PWLEs, and 60.4% from LMICs) involved re-ranking the results from Round 2. Smith's salience index was calculated to measure consensus and Kendall's coefficient of concordance to determine the degree of agreement. Narrative opinions and feedback from panellists during all three Delphi rounds were also sought.</p><p><strong>Results: </strong>A list of indicators within five core measurement domains was identified in Round 1. Round 2 results were heterogeneous as indicated by the low to moderate salience of most indicators. Round 3 resulted in 4-5 indicators in each domain, that were ranked as highly salient by the expert panellists. Experts also provided narrative feedback on the definition of structural stigma, barriers to its measurement, domain-specific comments, and indicators-specific comments.</p><p><strong>Conclusion: </strong>The framework aids in defining mental health-related structural stigma in healthcare and framing it in terms of inequities within healthcare system structures. These structures result in negative experiences of PWLEs and limit their access to quality healthcare. This conceptualization, informed by PWLE and stakeholders in LMICs, makes it easier to measure structural stigma and monitor changes in diverse healthcare settings around the world.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0316999"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV viral load suppression rates among adults and children living with HIV in the North West Region of Cameroon: A call for action!","authors":"Gladys Fosah E Tayong, Melissa Sander, Comfort Vuchas, Moses Samje, Vera Kum, Pascal Enokbonong, Eugene Yeika, Ndanga Bekombo, Paul Nyibio, Vanessa B Ngwani, Justin Ndié, Njamnshi Wepnyu Yembe, Gloria Ashuntangtang","doi":"10.1371/journal.pone.0316399","DOIUrl":"10.1371/journal.pone.0316399","url":null,"abstract":"<p><strong>Introduction: </strong>HIV continues to be a major public health problem in Cameroon where 2.7% of the population aged 15 to 49 are living with HIV. The prevalence remains higher in females, 3.4% versus 1.9% in males. The North West region of Cameroon has a higher prevalence than the national average; 4% in the general population, 5.8% in females and 1.6% in males. Despite the availability of pediatric HIV treatment, gaps in outcomes of children living with HIV (CLHIV) persists. This study aimed to compare the HIV viral suppression rates among adults and children living with HIV receiving antiretroviral therapy (ART) in the North West Region of Cameroon. In this study we hypothesized that the virologic outcome of children living with HIV is unfavorable compared to adults.</p><p><strong>Methodology: </strong>This study was a comparative cross-sectional analytical study with secondary analysis of Viral load laboratory database. Data was collected in June 2023. We systematically collected deidentified data on viral load test of all PLHIV with HIV viral load results in the Bamenda TB reference laboratory database for the period January 1, 2022 to December 31, 2022. Data was analyzed using Stata SE 14.2. Categorical variables were described using absolute and relative frequencies. These were compared using Pearson's chi-squared test. Quantitative variables were described using mean as a characteristic of central tendency and standard deviation (SD) as a characteristic of dispersion.</p><p><strong>Results: </strong>Analysis revealed that of the 23,814 PLHIV whose viral load test was done at the Bamenda TB reference laboratory during the year 2022, 17,364(73%) were female and 1436 (6%) were children. The level of HIV viral suppression (viral load<1000 copies/ml) in children was lower compared to that of adults (80% vs. 95%; p<0.001). Females had lower viral suppression than males (94% vs. 91%; p<0.001).</p><p><strong>Conclusion: </strong>The results revealed a significant lower HIV viral suppression rate in children than in adults. Women also had a significantly higher HIV viral suppression than males. Findings indicated that HIV viral suppression rate is significantly higher for routine viral load testing than for targeted testing after enhanced adherence counselling, thus the need to systematically offer enhanced adherence counselling and other evidence-based support interventions in routine care to all PLHIV to avoid persistent high viral non-suppression. Action is needed to tackle all known factors contributing to high viral non-suppression in children living with HIV and to help achieve 95% viral suppression rate in CLHIV in the North West region of Cameron.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0316399"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification and Regression Trees analysis identifies patients at high risk for kidney function decline following hospitalization.","authors":"Weihao Wang, Wei Zhu, Janos Hajagos, Laura Fochtmann, Farrukh M Koraishy","doi":"10.1371/journal.pone.0317558","DOIUrl":"10.1371/journal.pone.0317558","url":null,"abstract":"<p><p>Estimated glomerular filtration rate (eGFR) decline is associated with negative health outcomes, but the use of decision tree algorithms to predict eGFR decline is underreported. Among patients hospitalized during the first year of the COVID-19 pandemic, it remains unclear which individuals are at the greatest risk of eGFR decline after discharge. We conducted a retrospective cohort study on patients hospitalized at Stony Brook University Hospital in 2020 who were followed for 36 months post discharge. Random Forest (RF) identified the top ten features associated with fast eGFR decline. Logistic regression (LR) and Classification and Regression Trees (CART) were then employed to uncover the relative importance of these top features and identify the highest risk patients. In the cohort of 1,747 hospital survivors, 61.6% experienced fast eGFR decline, which was associated with younger age, higher baseline eGFR, and acute kidney injury (AKI). Multivariate LR analysis showed that older age was associated with lower odds of fast eGFR decline whereas length of hospitalization and vasopressor use with greater odds. CART analysis identified length of hospitalization as the most important factor and that patients with AKI and hospitalization of 27 days or more were at highest risk. After grouping by ICU and COVID-19 status and propensity score matching for demographics, these risk factors of fast eGFR decline remained consistent. CART analysis can help identify patient subgroups with the highest risk of post-discharge eGFR decline. Clinicians should consider the length of hospitalization in post-discharge monitoring of kidney function.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0317558"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective model of the potential clinical and economic impact of cervical cancer screening supported by a mobile phone app.","authors":"Fredrick Chite Asirwa, Brian W Bresnahan, Faith Yego, Dana Duncan, James K Karichu, Louis P Garrison","doi":"10.1371/journal.pone.0316001","DOIUrl":"10.1371/journal.pone.0316001","url":null,"abstract":"<p><strong>Introduction: </strong>Cervical cancer is a preventable and highly curable disease when detected early and adequately treated, yet it remains the leading cause of cancer-related death in women in Kenya due to low screening coverage and treatment. Implementing World Health Organization screening guidelines for human papillomavirus (HPV) is challenging due to the complex logistics of result return and follow-up requiring multiple clinic visits. Increasing the use of mobile technology can support follow-up care in cervical cancer screening programs.</p><p><strong>Methods: </strong>We developed a prospective clinico-economic model to assess the potential impact of a mobile phone-based application (\"app\") communicating laboratory results and recommendations to improve follow-up care for cervical cancer screening in Kenya. The model is structured to simulate a three-visit pathway for HPV-based screening used in a clinical trial of the app and based on epidemiological data, clinical guideline-based workflow, and patient-based behavioral pathways. Published literature, expert elicitation, and time-and-motion observations were used to estimate clinical data, care pathways, and visit-related costs. This analysis was conducted from a base-case healthcare system perspective with a scenario from a \"limited\" societal perspective.</p><p><strong>Results: </strong>In a simulated cohort of women using the app-based intervention compared to conventional care, with 10,000 women in each arm, use of the app is projected to increase healthcare costs by $12.53 per enrolled woman during the trial period and to detect and treat an additional 247 women-229 with precancerous cervical lesions and 18 with cervical cancer. The incremental cost-effectiveness ratio of the app versus conventional care was $174 per case detected and treated. This would be cost-saving given the average lifetime cost per cervical cancer case of $1,000-$3,000.</p><p><strong>Conclusion: </strong>Use of a mobile phone-based app is costlier than conventional screening but by improving visit compliance, it can be a cost-effective and cost-saving strategy to enhance detection and treatment in cervical cancer screening programs.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0316001"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of workplace milieu resources on the relationship between emotional intelligence and burnout among leaders in social care.","authors":"Anna Kozák, Réka Schutzmann, Klára Soltész-Várhelyi, Fruzsina Albert","doi":"10.1371/journal.pone.0317280","DOIUrl":"10.1371/journal.pone.0317280","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the connection between emotional intelligence and burnout through the mediating role of workplace milieu resources (a sense of community and mutual trust between employees) among social care leaders in Hungary utilizing the Job Demand-Resources model as a reference. The study evaluated emotional intelligence across three dimensions: understanding our emotions, understanding others' emotions, and positive emotional appraisal.</p><p><strong>Methods: </strong>A cross-sectional and quantitative study was conducted from 11th April to 30th November 2019 targeting Hungarian social care leaders. Participants (N = 547) were recruited non-randomly trough a training organized for them. Data collection involved sociodemographic questions, the Assessing Emotions Scale and the Copenhagen Psychosocial Questionnaire. Descriptive statistics, Pearson's correlation, and three saturated serial mediations (ML with percentile bootstrap) were implemented. During the mediations, one dimension of emotional intelligence was used as a predictor in each model with the sense of community and mutual trust as serial mediators, and burnout as the outcome.</p><p><strong>Results: </strong>The results confirmed the role of the leader's emotional intelligence in creating a supportive workplace atmosphere and its indirect effect on burnout through these workplace milieu resources, while its direct effect was found not to be substantial. Among the three aspects of emotional intelligence, positive appraisal had the largest effect on burnout.</p><p><strong>Conclusions: </strong>This study suggests that emotional intelligence' influence on burnout is mediated by workplace milieu resources. Therefore, it is crucial to encourage leaders to use their emotional intelligence to create a positive emotional atmosphere rather than solely concentrating on emotional comprehension.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0317280"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding how intermediaries connect adults to community-based physical activity: A qualitative study.","authors":"Megan O'Grady, Emer Barrett, Deirdre Connolly","doi":"10.1371/journal.pone.0318687","DOIUrl":"10.1371/journal.pone.0318687","url":null,"abstract":"<p><p>Intermediaries facilitate connections to community-based services and supports, including physical activity and exercise groups, and are an emerging method to promote physical activity participation. However, their processes when establishing connections to community-based physical activities are unclear. The aim of this study was to explore the processes, practices, and procedures of Irish intermediaries when connecting people to community-based physical activity. This was a qualitative descriptive design study. Semi-structured interviews were carried out with n = 27 intermediaries from a variety of sectors-Health Promotion and Improvement [HPO], Local Sports Partnerships [LSO] and Social Prescribing [SP]. Four themes were identified using qualitative content analysis; 1) the processes of connecting to an intermediary, 2) connecting individuals to physical activity, 3) exiting from the intermediary service and 4) working in the local context. Intermediaries reported that they received referrals for individuals with physical, mental, and social health needs, but that referrals to improve physical activity specifically were low. They used a person-centred approach throughout their process, often addressing barriers to physical activity. However, only LSO and SP facilitated connections to physical activity, as HPO mainly focused on delivering smoking cessation support and services. Levels of support given and length of follow-up varied between LSO and SP, with the latter providing more intensive support. To facilitate their work, they developed extensive local knowledge and networks of partners, which enabled connections to a variety of community-based physical activities. Intermediaries may be an under-utilized resource to promote physical activity. Understanding the processes used in their interventions can inform future research, which is needed to investigate the effectiveness of intermediaries in improving physical activity levels and to inform future referral pathways.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 1","pages":"e0318687"},"PeriodicalIF":2.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}