PLoS ONE最新文献

{"title":"Correction: Biomechanical effects of saddle height changes in leisure cycling with unilateral transtibial prostheses: A simulated study.","authors":"Heloisa Seratiuk Flores, Wen Liang Yeoh, Ping Yeap Loh, Kosuke Morinaga, Satoshi Muraki","doi":"10.1371/journal.pone.0321575","DOIUrl":"https://doi.org/10.1371/journal.pone.0321575","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0317121.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0321575"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does physical activity-based intervention decrease repetitive negative thinking? A systematic review.","authors":"Shimeng Wang, Mingyang Lu, Xiaoxiao Dong, Yifan Xu","doi":"10.1371/journal.pone.0319806","DOIUrl":"https://doi.org/10.1371/journal.pone.0319806","url":null,"abstract":"<p><strong>Background: </strong>Repetitive negative thinking (RNT) is characterized by its persistence, difficulty in control, and the tendency to focus on negative thoughts and past events. It is recognized as a key factor in the development and maintenance of mental health issues such as depression and anxiety. A growing body of research suggests that physical activity-based interventions may effectively reduce RNT. However, the extent of this effect and the mechanisms behind it remain inconsistent across studies.</p><p><strong>Methods: </strong>This systematic review synthesized evidence from 19 peer-reviewed studies retrieved from PubMed, Web of Science, and other relevant databases up to December 2024. The objective was to investigate the efficacy of physical activity-based interventions in reducing RNT, with a particular focus on the influence of intervention type, duration, frequency, and intensity.</p><p><strong>Results: </strong>The review found that physical activity interventions effectively reduce RNT, particularly when combined with psychological training. Combined interventions yielded greater reductions than physical activity alone. Moderate-to-high intensity exercise (30-60 min/session, 3-5 times/week) over an extended period was most effective, likely due to physiological, psychological, and social mechanisms. Single-session interventions showed limited effects, emphasizing the need for sustained engagement. Notably, interventions were more effective in individuals with depression, anxiety, or chronic stress, whereas effects in healthy individuals were smaller and more variable, suggesting that baseline symptomatology enhances intervention benefits.</p><p><strong>Conclusions: </strong>This review underscores the importance of designing intervention protocols that integrate both physical and psychological components to achieve greater reductions in RNT. The findings provide empirical support for the use of combined interventions involving physical activity and psychological training as an effective strategy for managing RNT. Additionally, future research should prioritize identifying optimal intervention characteristics (e.g., type, frequency, intensity) and addressing methodological limitations, such as the inclusion of diverse participant samples and broader language coverage, to provide more comprehensive insights into effective intervention strategies. These findings have important implications for mental health interventions and offer practical guidance for developing evidence-based approaches to reduce RNT.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0319806"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Cultural framing of giftedness in recent US fictional texts.","authors":"","doi":"10.1371/journal.pone.0321613","DOIUrl":"https://doi.org/10.1371/journal.pone.0321613","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0307222.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0321613"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Novel deep reinforcement learning based collision avoidance approach for path planning of robots in unknown environment.","authors":"Raed Alharthi, Iram Noreen, Amna Khan, Turki Aljrees, Zoraiz Ali, Nisreen Innab","doi":"10.1371/journal.pone.0321810","DOIUrl":"https://doi.org/10.1371/journal.pone.0321810","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0312559.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0321810"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Employee informal coaching and job performance in higher education: The role of perceived organizational support and transformational leadership.","authors":"Giang Thuy Nguyen, Jana Matošková, Nhat Tan Pham, Man The Nguyen","doi":"10.1371/journal.pone.0320577","DOIUrl":"https://doi.org/10.1371/journal.pone.0320577","url":null,"abstract":"<p><p>The existing literature has not adequately explored the connection between informal coaching and employees' job performance, particularly in higher education institutions (HEIs). Anchored in the social exchange theory, this study aims to investigate the impact of informal coaching practices on job performance, as well as the mediating and moderating roles of perceived organizational support and transformational leadership. Results from a time-lagged study of 768 participants in HEIs in Vietnam indicate that informal coaching from supervisors and peers is crucial in directly enhancing employee performance. Furthermore, the research indicates that perceived support from the organization plays a vital role in mediating the impact of informal coaching on individual job performance. Interestingly, the study suggests that high levels of transformational leadership strengthen the relationships between informal coaching from supervisors and employees' job performance, as well as informal coaching from supervisors and perceived organizational support. However, contrary to expectations, transformational leadership does not moderate the influence of informal coaching from peers on job performance and perceived organizational support.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0320577"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The cross-sectional association between state-level public health funding per capita and physical health among adults in the United States.","authors":"Stephen Hunter, Sze Y Liu, Daniel M Cook, Kia L Davis, Brendan T Smith, Roman Pabayo","doi":"10.1371/journal.pone.0320920","DOIUrl":"https://doi.org/10.1371/journal.pone.0320920","url":null,"abstract":"<p><strong>Objectives: </strong>This study examined the association between state-level public health funding per capita and the odds of poor physical health.</p><p><strong>Study design: </strong>Cross-sectional.</p><p><strong>Methods: </strong>Data from the 2018 Behavioral Risk Factor Surveillance System (BRFSS) were used. Participants' self-reported physical health was reported using the CDC Healthy Days Core Module. State-level public health funding per capita was obtained from the State Health Access Data Assistance Center website. Multilevel logistic regression was used to adjust for self-reported individual-level characteristics and state-level characteristics from the 2018 American Community Survey. We also tested whether household income or education attainment moderated any observed associations.</p><p><strong>Results: </strong>A one SD increase in state-level public health funding per capita was not associated with the odds ≥  14 days of poor physical health (OR = 0.96, 95% CI: 0.90, 1.01). However, heterogeneity across household income was observed. Greater public health funding per capita was associated with lower predicted probabilities of reporting ≥  14 days of poor physical health among respondents from low household income backgrounds ( <$35,000 USD) compared to participants with high household incomes (>$75,000 USD). No associations were observed among those with moderate ($35,000 - $70,000 USD) household incomes. A similar finding was observed among participants with less than high school education when compared to participants with post-secondary education.</p><p><strong>Conclusion: </strong>Greater state-level public health funding per capita appears to have a protective association against reporting ≥  14 days of poor physical health in individuals with lower household incomes and may be helpful in reducing health inequities. Future research is needed to determine whether this association is causal.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0320920"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deubiquitination of epidermal growth factor receptor by ubiquitin-specific peptidase 54 enhances drug sensitivity to gefitinib in gefitinib-resistant non-small cell lung cancer cells.","authors":"Mi Seong Kim, Min Seuk Kim","doi":"10.1371/journal.pone.0320668","DOIUrl":"https://doi.org/10.1371/journal.pone.0320668","url":null,"abstract":"<p><p>A precise balance between ubiquitination and deubiquitination is crucial for cellular regulation. Ubiquitin-specific peptidase 54 (USP54), an active deubiquitinase (DUB), modulates the ubiquitination of the epidermal growth factor receptor (EGFR). While the significance of USP54 in tumorigenesis is known, its specific function in cancer progression remains unclear. This study investigates the role of USP54 in gefitinib sensitivity in gefitinib-resistant non-small cell lung cancer (NSCLC) cells. Using western blotting and next-generation sequencing, we examined gene expression changes in ubiquitination pathways. USP54 deficiency and its impact on cell viability and gefitinib response were evaluated in 2D and 3D spheroid cancer models. Prolonged gefitinib exposure altered the expression of 20 deubiquitinase-regulating genes. Notably, ubiquitin C-terminal hydrolase L3, downregulated by gefitinib, was identified as a key regulator of EGFR ubiquitination in gefitinib-sensitive PC9 cells. Silencing USP54 in resistant NSCLC cells increased gefitinib-induced EGFR ubiquitination and G0/G1 cell cycle arrest, enhancing drug susceptibility in resistant spheroids. USP54 upregulation in gefitinib-treated cells was associated with reduced EGFR ubiquitination, stabilizing EGFR and promoting cell survival. These findings suggest USP54 as a critical modulator of EGFR stability and a potential therapeutic target to overcome gefitinib resistance in NSCLC.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0320668"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experienced inclusion and recognition amongst people with spinal cord injury: A comparative study in Norway, The Netherlands, and Australia.","authors":"Annelie Schedin Leiulfsrud, Kristian Bernhof Ellinggard, Marcel W M Post, Mohit Arora, Håkon Leiulfsrud","doi":"10.1371/journal.pone.0306231","DOIUrl":"https://doi.org/10.1371/journal.pone.0306231","url":null,"abstract":"<p><strong>Background: </strong>The aim of this article is to study inclusion and recognition experienced amongst people with a Spinal Cord Injury (SCI) in Norway, The Netherlands, and Australia. This is approached both from the perspectives of an interest in the impact of mobility limitations versus social attitudes, and from a consideration of differences between societies.</p><p><strong>Methods: </strong>The data derive from the core questionnaire of International Spinal Cord Injury Community Survey with extended national modules on the attitudes and values of respondents from Norway, The Netherlands, and Australia. The data gathered in 2017-18 include 2,450 participants aged 18 years or older. The data are analysed and presented with descriptive statistics and OLS regression analyses. In order to explore our main questions, we run regression controlling for country effects in addition exploring within country effects.</p><p><strong>Results: </strong>Mobility limitations are a substantially weaker predictor of self-perceived inclusion and recognition than experiences of negative attitudes towards disabled people. Stereotypical attitudes and norms in society are shown to have various impacts on inclusion in the three countries. The Norwegian respondents report overall better results on inclusion and recognition than respondents in Australia and The Netherlands, illustrating the importance of national contexts.</p><p><strong>Conclusions: </strong>Challenges associated with inclusion, recognition, and respect after SCI need to be defined in a language broader than mobility limitations and stereotypical attitudes towards people with an SCI. The main road to both inclusion and recognition in society is primarily linked to job and educational status, in addition to family and friends. The results are of particular interest as measures to support reintegration into society, including a strengthening of labour market integration programs.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0306231"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voluntarily wheel running protects doxorubicin-induced kidney injury by inhibiting oxidative stress through mitochondrial function.","authors":"Xin Jiang, Zeyu Wang, Longyun Wang, Yuqi Wang, Lijing Zhao, Hongyu Jiang","doi":"10.1371/journal.pone.0321121","DOIUrl":"https://doi.org/10.1371/journal.pone.0321121","url":null,"abstract":"<p><strong>Background: </strong>Doxorubicin (DOX) has a broad anticancer spectrum and precise anticancer effects, but its clinical application is limited by severe multiorgan toxicity, among which nephrotoxicity is one of the main adverse reactions. In this study, the protective effect of voluntary wheel running on nephrotoxicity induced by DOX was observed, and its mechanism was initially discussed.</p><p><strong>Methods: </strong>Forty male C57BL/6 mice were randomly divided into a control group (CTR), a voluntary wheel running group (EX), a doxorubicin model group (DOX) and a doxorubicin combined with voluntary wheel running group (COM). After 2 weeks of exercise, the mice were sacrificed. Serum creatinine (CREA), urea nitrogen (BUN), uric acid (UA), carbon dioxide combining power (CO2-CP), renal tissue apoptosis, oxidative stress and mitochondrial function indicators were assessed.</p><p><strong>Results: </strong>Compared with those in the DOX group, the concentrations of CREA, BUN and UA decreased, the number of TUNEL-positive cells in kidney tissue decreased, the expression of antiapoptotic proteins increased, and the expression of proapoptotic proteins decreased in the COM group. In addition, the COM can reduce the ROS and MDA contents in kidney tissue, reduce peroxide accumulation and alleviate mitochondrial respiratory chain damage caused by DOX.</p><p><strong>Conclusions: </strong>Voluntary wheel running can improve the mitochondrial function of renal cells and reduce oxidative stress damage, thus playing a protective role against nephrotoxicity caused by DOX. This study provides a new way to reduce the adverse reactions to chemotherapy in combination with the application of chemical drugs.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0321121"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive study on characterization of biosynthesized copper-oxide nanoparticles, their capabilities as anticancer and antibacterial agents, and predicting optimal docking poses into the cavity of S. aureus DHFR.","authors":"Ehab S Gad, Salem S Salem, Samy Selim, Mohammed S Almuhayawi, Mohammed H Alruhaili, Soad K Al Jaouni, Amna A Saddiq, Medhat E Owda","doi":"10.1371/journal.pone.0319791","DOIUrl":"https://doi.org/10.1371/journal.pone.0319791","url":null,"abstract":"<p><p>The eco-friendly method of producing copperـoxide nanoparticles through the use of okra fruit extract is a simple, economical, rapid, and sustainable technique. The resultant copperـoxide nanoparticles (CuO NP) were analyzed with several analytical methods, such as UV-vis spectroscopy, FourierـTransform Infrared Spectroscopy (FT-IR), and X-Ray Diffraction (XRD), Zeta potential, TransmissionـElectron Microscopy (TEM) and EnergyـDispersive X-ray (EDX) analysis. The CuO NP exhibited a maximum absorbance at 381 nm. The formation of CuO NP was further confirmed by characteristic bands observed at 534 and 588 cm-1. The monoclinic structure of the CuO NP was identified with prominent peaks detected at 2θ values of 32.47°, 35.43°, 38.64°, 48.68°, 53.38°, 58.14°, 61.39°, 66.11°, 67.82°, 72.27°, and 74.96°. The overall findings indicate that the nanoparticles had an average diameter in the approximate range of 10 to 30 nm based on the TEM analysis. The cytotoxicity study, conducted on Human Fibroblast normal HFB4 cell lines, indicated that the halfـmaximal inhibitory concentration (IC50) dose was 236.34 μg/mL. An IC50 dose of 109.46 μg/mL was found in antitumor effect studies using breast adenocarcinoma Mcf- 7 cell lines, revealing a good level of safety for CuO NP. According to the antibacterial study, Staphylococcus aureus and Bacillus cereus had inhibition zone diameters (IZDs) of 29.5 ± 0.7 mm and 24.6 ± 1.2 mm, respectively, making them the most vulnerable bacteria to CuO NP. In contrast, P. aeruginosa was the least sensitive strain, with a minimum IZD of 15 ± 1.6 mm. Compared to gram-negative infections, the CuO NPs were found to have a significantly higher antibacterial effectiveness versus Gram -positive pathogens. Molecular docking against dihydrofolate reductase (DHFR) of Staphylococcus aureus (PDB ID: 6P9Z) illustrated that the CuO NP was partially interlocked with the active site of 6P9Z by the fitting energy value of -44.93 kcal/mol through five classical hydrogen bonds with Ala7, Gln9, Thr46, Ser49, and Phe92. The last one is also generated by the marketing antifolate agent methotrexate (MTX), adding some MTX-like character to the CuO NP inhibitor.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0319791"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}