PLoS ONE最新文献

{"title":"Voluntarily wheel running protects doxorubicin-induced kidney injury by inhibiting oxidative stress through mitochondrial function.","authors":"Xin Jiang, Zeyu Wang, Longyun Wang, Yuqi Wang, Lijing Zhao, Hongyu Jiang","doi":"10.1371/journal.pone.0321121","DOIUrl":"https://doi.org/10.1371/journal.pone.0321121","url":null,"abstract":"<p><strong>Background: </strong>Doxorubicin (DOX) has a broad anticancer spectrum and precise anticancer effects, but its clinical application is limited by severe multiorgan toxicity, among which nephrotoxicity is one of the main adverse reactions. In this study, the protective effect of voluntary wheel running on nephrotoxicity induced by DOX was observed, and its mechanism was initially discussed.</p><p><strong>Methods: </strong>Forty male C57BL/6 mice were randomly divided into a control group (CTR), a voluntary wheel running group (EX), a doxorubicin model group (DOX) and a doxorubicin combined with voluntary wheel running group (COM). After 2 weeks of exercise, the mice were sacrificed. Serum creatinine (CREA), urea nitrogen (BUN), uric acid (UA), carbon dioxide combining power (CO2-CP), renal tissue apoptosis, oxidative stress and mitochondrial function indicators were assessed.</p><p><strong>Results: </strong>Compared with those in the DOX group, the concentrations of CREA, BUN and UA decreased, the number of TUNEL-positive cells in kidney tissue decreased, the expression of antiapoptotic proteins increased, and the expression of proapoptotic proteins decreased in the COM group. In addition, the COM can reduce the ROS and MDA contents in kidney tissue, reduce peroxide accumulation and alleviate mitochondrial respiratory chain damage caused by DOX.</p><p><strong>Conclusions: </strong>Voluntary wheel running can improve the mitochondrial function of renal cells and reduce oxidative stress damage, thus playing a protective role against nephrotoxicity caused by DOX. This study provides a new way to reduce the adverse reactions to chemotherapy in combination with the application of chemical drugs.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0321121"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of University Students' Mental Health from the Perspective of Occupational Harmony.","authors":"Yijun Liu, Ruiqi She, Jin Xing","doi":"10.1371/journal.pone.0309490","DOIUrl":"https://doi.org/10.1371/journal.pone.0309490","url":null,"abstract":"<p><strong>Background: </strong>Mental health problems are common among university students. Based on the Model of Occupational Harmony, we investigated the relationship between occupational engagement and mental health among Chinese university students.</p><p><strong>Methods: </strong>A mixed methods approach was adopted. A total of 734 Chinese university students responded to online questionnaires: a socio-demographic questionnaire, the Depression Anxiety Stress Scale, the WHOQOL-BREF, and a self-designed Occupational Harmony Questionnaire. Individual interviews with 11 university students and a focus group of four students provided qualitative data.</p><p><strong>Results: </strong>Anxiety, depression, and stress were reported by 11.9%, 9.4%, and 2.9% of the participants, respectively. The level of occupational harmony was negatively correlated with depression, anxiety, and stress (p <  .001). The DASS-21 score was significantly different among students who spent different amounts of time on the following activities: exercise, sleep, rest, reflective and consulting activities, study, work, and leisure and entertainment (P < .05). In the context of the COVID-19 pandemic, the key occupational factors contributing to university students' mental health problems included excessive mental engagement and insufficient physical engagement, excessive active engagement and insufficient quiet engagement, insufficient social engagement, excessive or insufficient Gong (productive) engagement, and insufficient De (virtuous) engagement, Zhi (rational) engagement, and Kang (health maintenance) engagement, lack of coherence within the family, school, social systems, as well as inadequate schedule planning and time management.</p><p><strong>Conclusions: </strong>Occupational disharmony is related to university students' mental health problems. Occupational therapy can promote university students' mental well-being by enhancing occupational harmony.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0309490"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of subjective age trajectories with loneliness and stress across adulthood.","authors":"Anna E Kornadt, Markus Wettstein, Anthony Lepinteur, Claus Vögele, Conchita D'Ambrosio","doi":"10.1371/journal.pone.0320673","DOIUrl":"https://doi.org/10.1371/journal.pone.0320673","url":null,"abstract":"<p><p>Subjective age, that is the age a person feels like in relation to their chronological age, is indicative of a variety of biological, psychological, and social aging processes. Despite its importance, studies that investigate multi-variate, dynamic, longitudinal relations of subjective age with its potential determinants and potential mechanisms of these relations have so far rarely been employed. In the current study, we focus on loneliness as a potential subjective age determinant. As loneliness affects a variety of psychosocial and health outcomes across life and is stereotypically perceived as a feature of old age, we investigate whether loneliness is related with levels and changes in subjective age. We furthermore test whether this association is mediated via self-reported stress. N =  5,594 participants aged 18 - 93 years (Mage =  50.41, SD =  15.99) who participated in a longitudinal survey comprising up to three measurement occasions over a time span of 2.5 years reported their loneliness, subjective age, and stress as well as sociodemographic and health-related covariates. We employed latent growth modeling and found that, when controlling for sociodemographic and health-related covariates, higher loneliness was related to an older subjective age cross-sectionally and to a steeper increase in subjective age over time. These relations were mediated via stress; however, the relation between stress and subjective age was no longer statistically significant when including the covariates. All associations were qualified by significant interactions with chronological age, albeit in different directions. Our findings attest to associations between loneliness, stress and subjective aging experiences and highlight the need for an age-informed approach when planning further studies and interventions.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0320673"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing anomalous events in passageways with high-frequency ship signals.","authors":"Cherryl Chico, Macario O Ii Cordel, Mahinthan Joseph Mariasingham, Elaine S Tan","doi":"10.1371/journal.pone.0320129","DOIUrl":"https://doi.org/10.1371/journal.pone.0320129","url":null,"abstract":"<p><p>Passageways are critical gateways in maritime trade, providing efficient routes for global commerce. This means that disruptions such as natural disasters or human error at these crucial points can significantly impact numerous economies across various facets of trade. Thus, real-time monitoring of such events and their impact on different vessel types is crucial for developing timely mitigation strategies, policies, and penalties. This paper proposes a novel framework for analyzing anomalous events in passageways using Automated Information System (AIS). This framework enables monitoring of affected vessels and quantifies the impact in terms of the number of vessels, dwell and idle times, and the emergence of new routes. To demonstrate its potential, we applied the proposed framework to the Suez Canal blockage in March 2021. Results revealed distinct phases during the event, with each phase impacting average dwell times. Additionally, the analysis identified the emergence of passageway event-driven routes utilized by vessels to bypass the blockage. These findings highlight the ability of the proposed framework to capture previously obscured information compared to existing indicators and port analysis methods. To further demonstrate its generalizability, the methodology was also applied to two other passageways: the Bosporus Strait, following the policy implemented in February 2022 due to the Russian invasion of Ukraine, and the Bab el-Mandeb Strait, following the disruption caused by the Houthi attacks beginning in the last quarter of 2023.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0320129"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence (AI) in nursing administration: Challenges and opportunities.","authors":"Omar Qaladi, Mukhlid Alshammari, Abdullah Abdulrahim Almalki","doi":"10.1371/journal.pone.0319588","DOIUrl":"https://doi.org/10.1371/journal.pone.0319588","url":null,"abstract":"<p><p>Artificial Intelligence (AI) is increasingly transforming nursing administration by enhancing operational efficiency and supporting data-driven decision-making. This study explores registered nurses perceptions of AI in Saudi Arabia, focusing on both challenges and opportunities. A cross-sectional survey of 202 nurses revealed that 93.6% believe AI improves understanding, and 88.1% feel it enhances the quality of learning. Significant correlations were found between years of experience and AI usage (r =  0.342, p <  0.001) and between sources of information and AI perception (r =  0.146, p =  0.039). While 80.7% expressed concern that AI could reduce critical thinking, 76.8% feared job displacement. These findings underscore the need for training, ethical guidelines, and support systems to foster effective AI integration, enhancing nursing practice while addressing concerns around professional roles.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0319588"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of excessive screen time exposure with ocular changes leading to astigmatism in children.","authors":"Mutahir Shah, Satheesh Babu Natarajan, Nafees Ahmad","doi":"10.1371/journal.pone.0317961","DOIUrl":"https://doi.org/10.1371/journal.pone.0317961","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to find the relationship between excessive screen time exposure and the development of astigmatism in children.</p><p><strong>Methods: </strong>A cross-sectional correlational study was conducted at tertiary care hospital, Islamabad between June 2023 to May 2024. In total, 431 patients were included in this study after informed written consent. Screen time exposure was assessed through smartphone usage history or parental reports of daily use of smart gadget(s). Tear break-up time was measured using a fluorescein strip, cobalt blue filter on a slit-lamp biomicroscope and a stopwatch. Data was analyzed using univariate and multivariate statistical tests including Spearman's correlation and regression analyses.</p><p><strong>Results: </strong>The study included 431 children (mean age: 6.70 ±  1.80 years; 55% male, 45% female). Mean screen time was 4.54 ±  1.52 hours/day. A positive correlation between screen time and the magnitude of astigmatism was observed (r = 0.33, p < 0.001). Regression analysis showed a significant relationship among screen time and astigmatism (B = 0.177, CI: 0.80-0.25). Tear break- up time (TBUT) showed a significant negative correlation with screen time (r = -0.167, p < 0.001), and reduced TBUT was linked to a higher risk of inflammatory conjunctivitis and lid thickening (B = -0.431, CI: -0.12 to -0.49, p < 0.001). The results highlighted that inflammatory conjunctivitis/lid thickness have three times greater risk of developing high astigmatism (OR =  3.31, p-value <  0.001, CI =  1.91 to 5.73) while the risk of moderate astigmatism in such cases was two times higher (2.12, p-value =  0.004, CI = 1.26-3.56). However, the effect of lid thickness on astigmatism when combining with screen time has a little effect that is not significant (p-value = 0.053). Thus, excessive screen time is an independent risk factor of causing astigmatism in children (p < 0.001). The Wilcoxon Signed Ranks Test demonstrated significant improvement in visual acuity after correction (p < 0.001).</p><p><strong>Conclusion: </strong>Excessive screen time in children is significantly associated with astigmatism, tear film instability, inflammatory ocular conditions, including conjunctivitis and lid thickening. These findings suggest the need for preventive strategies, such as reducing screen time and encouraging regular eye examinations, to protect children's ocular health.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0317961"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications for Precision Accelerated Clinically Embedded Research (PACER): A novel technology-enabled approach to conducting minimal-risk research in outpatient community healthcare settings.","authors":"Emma Friedman, Kelly Nicole Michelson, Shruti Sehgal, Russell Steans, Mohammad Hosseini, Matthew J Baumann, Amanda K Venables, Theresa L Walunas, Justin Starren","doi":"10.1371/journal.pone.0318533","DOIUrl":"https://doi.org/10.1371/journal.pone.0318533","url":null,"abstract":"<p><p>Current challenges in the clinical research landscape include insufficient enrollment of study participants, lack of study participant diversity, protracted study progression, and the siloing of research within academic medical centers. Recent advances in technology could minimize barriers to producing effective, timely, and comprehensive clinical research by addressing issues from study design to dissemination of results. Particularly, the Fast Health Interoperability Resources standards and Clinical Decision Support Hooks could support data acquisition, sharing, and expansion of research across organizations and disparate electronic health records. We developed a novel approach, Precision Accelerated Clinically Embedded Research (PACER), that leverages these advances in healthcare technology to integrate very short, minimal-risk research activities into clinical encounters. PACER could enable scalable, efficient, and cost-effective clinical research and has enormous potential. However, PACER also presents potential ethical, sociotechnical, and implementation quandaries. The current study aimed to obtain insights on these matters from relevant individuals. We conducted 47 qualitative semi-structured interviews with patients, clinicians, research experts (individuals involved in developing and conducting research), and bioethicists. We sought participants' perspectives on the potential ethical, sociotechnical, and implementation issues raised by PACER. We identified five key domains: impacts on clinical research, consent, compensation, impacts on people and organizations, and implementation. We examined interview participants' views using bioethical principles of autonomy, justice/fairness, beneficence, and nonmaleficence. While participants had diverse views, these insights highlight important considerations for PACER implementation and suggest areas for future empirical work.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0318533"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of non-drinking and drinking adults in Taiwan and their implications in alcohol epidemiological studies.","authors":"Tsung Yu, Tzu-Jung Wong, Hsing-Yu Yang","doi":"10.1371/journal.pone.0320451","DOIUrl":"https://doi.org/10.1371/journal.pone.0320451","url":null,"abstract":"<p><strong>Background: </strong>Confounding is a major threat to causal inferences regarding alcohol and health. One proposed causal inference approach was to compare the associations obtained from cohorts in different countries, where we know the confounding structures are different. To explore the confounding structure related to alcohol and health in Taiwan, we compared differences in the characteristics of drinkers and non-drinkers, using data from the Nutrition and Health Survey in Taiwan (2013-2016).</p><p><strong>Methods: </strong>The cross-sectional survey data were collected nationwide and were representative of residents in Taiwan, which included 2,846 men and 2,833 women ages 19 years and older. We used information regarding alcohol drinking and covariates of sociodemographic and health behavior variables. We performed sex-stratified multinomial logistic regression to assess the associations between each independent variable and alcohol drinking (non-drinkers, occasional drinkers, and moderate drinkers).</p><p><strong>Results: </strong>Among men, 31% were non-drinkers, 7% former drinkers, 43% occasional drinkers, 13% moderate drinkers, and 5% heavy drinkers. Among women, 62% were non-drinkers, 1% former drinkers, 32% occasional drinkers, 4% moderate drinkers, and 1% heavy drinkers. In both men and women, occasional drinkers had higher educational levels and fewer family financial problems, but had more smoking and betel nut chewing behaviors than non-drinkers, after we adjusted for age. Moderate drinkers had even more smoking and betel nut chewing behaviors. Male moderate drinkers also reported more comorbidities than non-drinkers.</p><p><strong>Conclusions: </strong>We observed that occasional drinkers had a better socioeconomic position than non-drinkers; moderate drinkers seemed to have a worse risk profile than non-drinkers. These confounding patterns were different from that in Western countries and may thereby help us make causal inferences regarding alcohol and health.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0320451"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Cost-effectiveness of Left Ventricular Assist Devices (LVADs) as destination therapy in the UK: An economic modelling study.","authors":"Tuba Saygın Avşar, Louise Jackson, Pelham Barton, Sophie Beese, Hoong S Lim, David Quinn, Malcolm Price, David J Moore","doi":"10.1371/journal.pone.0321324","DOIUrl":"https://doi.org/10.1371/journal.pone.0321324","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1371/journal.pone.0312912.].</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0321324"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of Human Balance through a Reinforcement Learning-based Muscle Controller.","authors":"Kübra Akbaş, Carlotta Mummolo, Xianlian Zhou","doi":"10.1371/journal.pone.0320211","DOIUrl":"https://doi.org/10.1371/journal.pone.0320211","url":null,"abstract":"<p><p>Objective characterization of human balance remains a challenge and clinical observation-based balance tests during physical rehabilitation are often affected by subjectivity. On the other hand, computational approaches mostly rely on center of pressure (COP) tracking and inverted pendulum models, which do not capture the multi-joint and muscle contributions to whole-body balance. This study proposes a novel musculoskeletal modeling and control methodology to investigate human balancing capabilities in the center of mass (COM) state space. A musculoskeletal model is integrated with a balance controller trained through reinforcement learning (RL) to explore the limits of dynamic balance during postural sway. The RL framework consists of two interlinked neural networks (balance recovery and muscle coordination) and is trained using Proximal Policy Optimization (PPO) under multiple training strategies. By exploring recovery from random initial COM states with a trained controller, a balance region (BR) is obtained that encloses successful state-space trajectories. Comparing BRs obtained from different trained controllers with the analytical postural stability limits of a linear inverted pendulum model, we observe a similar trend in COM balanced states, but reduced recoverable areas. Furthermore, the effects of muscle weakness and neural excitation delay on the BRs are investigated, revealing reduced balancing capability in the COM state space. The novel approach of determining regions of stability through learning muscular balance controllers provides a promising avenue for personalized balance assessments and objective quantification of balance capability in humans with different health conditions.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 4","pages":"e0320211"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}