4区综合性期刊

All Life Pub Date : 2025-10-19 DOI: 10.1080/26895293.2025.2568836

Jian Zhong Cui, Ting‐Ting Li, Hua Li, Jian Shen, Sen Wang, Yang YanMing, Wenlu Song

{"title":"<i>Chlorella</i> sp. treatment of liquid digestates from <i>Humulus scandens</i> by phycoremediation coupled with high value-added biomass production","authors":"Jian Zhong Cui, Ting‐Ting Li, Hua Li, Jian Shen, Sen Wang, Yang YanMing, Wenlu Song","doi":"10.1080/26895293.2025.2568836","DOIUrl":"https://doi.org/10.1080/26895293.2025.2568836","url":null,"abstract":"Effluents derived from anaerobic digesters are sustainable sources for the cultivation of microalgae, which not only effectively treats digestate but also yields valuable raw materials for bio-based products. Humulus scandens fermented liquid (HSFL) was initially utilized for cultivating Chlorella sp. and has proven to be a promising medium for microalgal cultivation. However, further research is required before large-scale applications of both H. scandens digestate (HSD) and HSFL can be established. This study investigated the cultivation of Chlorella sp. within HSD and HSFL and investigated the possible utilization of the biomass generated under various experimental conditions, including different culture patterns and dilution proportions. The biomass dry weight concentration reached its maximum when it was cultivated in 15% HSFL. It reached 1.28 g L−1, which was 0.10 g L−1 higher than the 1.18 g L−1 obtained in BG11. In terms of HSD remediation, the maximum removal rates of chemical oxygen demand (COD), total nitrogen (TN), and total phosphorus (TP) reached 91.75%, 76.25%, and 92.58%, respectively. The maximum protein, carbohydrate, and lipid contents were 20.01%, 27.68%, and 43.88%, respectively.","PeriodicalId":48478,"journal":{"name":"All Life","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147884857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Classification of renal cell carcinoma based on immunogenomic profiling 基于免疫基因组图谱的肾细胞癌分类

4区综合性期刊

All Life Pub Date : 2025-02-23 DOI: 10.1080/26895293.2025.2467662

Yanfei Chen, Sian Chen, Jun Zou, Jiehui Zhong, Xuejin Zhu, Qing-Biao Chen, Bin Wang, Weide Zhong

{"title":"Classification of renal cell carcinoma based on immunogenomic profiling","authors":"Yanfei Chen, Sian Chen, Jun Zou, Jiehui Zhong, Xuejin Zhu, Qing-Biao Chen, Bin Wang, Weide Zhong","doi":"10.1080/26895293.2025.2467662","DOIUrl":"https://doi.org/10.1080/26895293.2025.2467662","url":null,"abstract":"Renal cell carcinoma (RCC) is the most common type of kidney cancer. Several studies have identified RCC subtypes based on genomic profiling. However, few studies have explored the stratification of RCC based on immune-associated gene sets, which may contribute to the optimal classification of patients with RCC who respond to immunotherapy. By analyzing the molecular and clinical data of RCC obtained from The Cancer Genome Atlas database, we classified RCC hierarchically based on the scores of 29 immune-associated gene sets, which were generated by single-sample gene-set enrichment analysis. The three RCC subtypes were Cluster1 (C1), Cluster2 (C2) and Cluster3 (C3), and they had distinct prognoses. The C1 subtype was associated with worse survival than the others, but the prognoses of the C2 and C3 subtypes were not significantly different. The three RCC subtypes also had distinct DNA damage markers, key immune characteristics, proportions of tumor-infiltrating immune cells, and gene expressions of immunomodulators. In addition to the immune-related pathways, some cancer-associated pathways were also overactivated for the C1 subtype, these included apoptosis and the PI3K-Akt signaling pathway. Finally, this study showed that immune signature-based classification has potential clinical implications for RCC treatment.","PeriodicalId":48478,"journal":{"name":"All Life","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.tandfonline.com/doi/pdf/10.1080/26895293.2025.2467662?needAccess=true","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular landscape of lung cancer: insights into therapeutic targets and clinical outcomes 肺癌的分子景观：对治疗靶点和临床结果的见解

4区综合性期刊

All Life Pub Date : 2024-10-29 DOI: 10.1080/26895293.2024.2417192

Saloni Mangal, Abhijit Debnath, Rupa Mazumder, Avijit Mazumder, Rajesh Kumar Singh, Jahanvi Sanchitra, Stephen Jan, Pratibha Pandey, Bimlesh Kumar, Anil Kumar Singh

{"title":"Molecular landscape of lung cancer: insights into therapeutic targets and clinical outcomes","authors":"Saloni Mangal, Abhijit Debnath, Rupa Mazumder, Avijit Mazumder, Rajesh Kumar Singh, Jahanvi Sanchitra, Stephen Jan, Pratibha Pandey, Bimlesh Kumar, Anil Kumar Singh","doi":"10.1080/26895293.2024.2417192","DOIUrl":"https://doi.org/10.1080/26895293.2024.2417192","url":null,"abstract":"Lung cancer is the leading cause of cancer-related deaths globally, accounting for 1.8 million fatalities in 2020. Genetic mutations, chromosomal abnormalities, transcription factors, mutations in tumor suppressor genes, and mutations in oncogenes have all been associated with an increased risk of LC development. Heterogeneity of the disease, resistance to chemotherapy, and side effects such as nausea and vomiting, fatigue, anemia, neuropathy, hair loss, and skin and nail changes are associated with conventional therapeutics such as chemotherapy, radiation therapy, and targeted therapy. Thus, the treatment of the disease urgently requires the discovery of novel therapeutic approaches. This review identifies and discusses key molecular and genetic targets for LC therapy, highlighting recent advancements and potential clinical applications. Our efforts encompass all biological targets and aim to increase our understanding of these processes to better comprehend the disease's molecular mechanisms and develop new drugs and more effective LC treatments.","PeriodicalId":48478,"journal":{"name":"All Life","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147885999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Habitat preference and diversity of bryophyte in the Jiulongshan National Forest Park, Eastern China 九龙山国家森林公园苔藓植物的生境偏好与多样性

4区综合性期刊

All Life Pub Date : 2023-11-01 DOI: 10.1080/26895293.2023.2271177

Pengcheng Ye, Xiaohui Qian, Jianyong Wu, Xiao Zhao

{"title":"Habitat preference and diversity of bryophyte in the Jiulongshan National Forest Park, Eastern China","authors":"Pengcheng Ye, Xiaohui Qian, Jianyong Wu, Xiao Zhao","doi":"10.1080/26895293.2023.2271177","DOIUrl":"https://doi.org/10.1080/26895293.2023.2271177","url":null,"abstract":"In densely populated, highly urbanized regions such as Zhejiang Province (eastern China), species are under enormous environmental pressures resulting from human activities, land use changes, and habitat fragmentation, which affect species composition and species diversity. Although eastern China is one of the most concentrated distribution areas of endemic bryophytes in East Asia, these species are also faced with the threats of habitat inadequacy. In order to get more information on bryophyte habitat and diversity, we investigated species composition, habitat preference, as well as species diversity differences of bryophytes under different habitat conditions in Jiulongshan National Forest Park (JNFP). In particular, the results showed that 108 specimens of bryophyte were collected in total, including 46 species in 32 genera of 21 families. Furthermore, we had found 12 species of bryophytes that had never been recorded before in Zhejiang Province. Remarkably, 40.74% of bryophytes were found to grow on natural rocks, followed by understories and roadside habitats. In addition, the Patrick richness index (R) varied most significantly among different habitats (p < 0.001). In a conservation perspective, natural rocks, roadways and understories should be preserved to protect bryophyte diversity.","PeriodicalId":48478,"journal":{"name":"All Life","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135272080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of cytotoxic and genotoxic potential of avobenzone and octocrylene on human skin fibroblast cells 阿伏苯宗和奥克烯对人皮肤成纤维细胞的细胞毒性和基因毒性潜力的评价

4区综合性期刊

All Life Pub Date : 2023-10-30 DOI: 10.1080/26895293.2023.2270171

Özgür Vatan, Duygu Sevinç, Dilek Yılmaz Çelik, A. Carine Aurelie Allounan, Özgün Teksoy, Neylan Oral, Huzeyfe Huriyet, Tolga Çavaş, Nilüfer Çinkılıç

引用次数: 0

Identification of potential hub genes and therapeutic drugs in ovarian cancer via bioinformatics analysis 通过生物信息学分析鉴定卵巢癌潜在中枢基因和治疗药物

4区综合性期刊

All Life Pub Date : 2023-10-30 DOI: 10.1080/26895293.2023.2270192

Xinyue Zhou, Zuofei Song, Jia Chen, Dongxue Wang, Jingli Sun

引用次数: 0

Investigation of the content of anabolic steroids in food supplements used in sports practice 体育运动中膳食补充剂中合成代谢类固醇含量的调查

4区综合性期刊

All Life Pub Date : 2023-10-26 DOI: 10.1080/26895293.2023.2270722

Elina Petkova-Gueorguieva, Stanislav Gueorguiev, Hristina Lebanova, Anna Mihaylova, Vasil Madzharov

{"title":"Investigation of the content of anabolic steroids in food supplements used in sports practice","authors":"Elina Petkova-Gueorguieva, Stanislav Gueorguiev, Hristina Lebanova, Anna Mihaylova, Vasil Madzharov","doi":"10.1080/26895293.2023.2270722","DOIUrl":"https://doi.org/10.1080/26895293.2023.2270722","url":null,"abstract":"The goal of this study is to establish the presence or absence of anabolic androgenic steroids in food supplements implemented in sports practice, to assess the health risk from intake of food supplements with quality and content discrepancies in conflict with the recommendations. The authors analysed 23 samples of food supplements by using liquid chromatographic methods. The presence/absence of substances with steroid structure was determined by considering the resulting chromatograms and using reference substances. The analysis of the resulting data showed that 11 out of 23 samples of food supplements did not contain anabolic steroid substances, while different amounts of androgenic steroid substances were identified in the other 12 samples. The results from the analyses confirmed the hypothesis formulated by the authors for possible presence of undeclared steroid ingredients in food supplements, and enabled the following conclusion: more than half of the tested food supplements contained undeclared anabolic steroids, all banned by the World Anti-Doping Agency, and their number in one of the samples could be more than one. The authors also revealed that the information on the product label and package concealed the undeclared ingredients of the food supplement and claimed for high efficacy and safety.","PeriodicalId":48478,"journal":{"name":"All Life","volume":"30 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136381587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological relevance of BRAF and SMO mutations in Chinese patients with ameloblastoma 中国成釉细胞瘤患者BRAF和SMO突变的临床病理相关性

4区综合性期刊

All Life Pub Date : 2023-10-24 DOI: 10.1080/26895293.2023.2270170

Chen Ruixue, Li Hexiang, Hou Yali, Li Xiangjun, Sun Xu, Wang Jie, Zhang Xudong

引用次数: 0

Experimental validation and bioinformatics analysis of hub genes in myocardial infarction 心肌梗死中心基因的实验验证及生物信息学分析

4区综合性期刊

All Life Pub Date : 2023-09-26 DOI: 10.1080/26895293.2023.2255753

Li-Jun Wang, Bai-Quan Qiu, Hua-Xi Zou, Cheng-Wu Gong, Song-Qing Lai, Jian-Jun Xu, Yong-Bing Wu, Ji-Chun Liu

{"title":"Experimental validation and bioinformatics analysis of hub genes in myocardial infarction","authors":"Li-Jun Wang, Bai-Quan Qiu, Hua-Xi Zou, Cheng-Wu Gong, Song-Qing Lai, Jian-Jun Xu, Yong-Bing Wu, Ji-Chun Liu","doi":"10.1080/26895293.2023.2255753","DOIUrl":"https://doi.org/10.1080/26895293.2023.2255753","url":null,"abstract":"There is an urgent need to explore and validate novel biomarkers relevant to patients with myocardial infarction (MI), which is the leading cause of death in the world. Dysregulated microRNAs (miRNAs) and messenger RNAs (mRNAs) based on two Gene Expression Omnibus microarrays were analyzed using bioinformatics technology and experiments. KEGG and GO enrichment analyses were performed to explore potential mechanisms of myocardial infarction progression. Immune infiltration analysis was used to assess the relationship between the immune microenvironment and myocardial infarction. The DOX-induced myocardial injury model was used to simulate myocardial infarction. qRT-PCR was performed to validate the expression of hub genes. 5 downregulated miRNAs and 14 upregulated mRNAs were identified in total. Functional analysis revealed that some immune-related pathways were significantly enriched. T cells CD8+ were mainly enriched in the normal tissues compared to the myocardial infarction tissues. Meanwhile, the T cells CD4+ memory resting were highly enriched in the myocardial infarction tissues compared to the normal tissues. Experimental validation of miRNAs and mRNAs contributed to the identification of 4 miRNAs and 12 mRNAs that may play a crucial role in the DOX-induced myocardial infarction cell model. Our study successfully identified several genes that may be related to myocardial infarction progression.","PeriodicalId":48478,"journal":{"name":"All Life","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134960672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Key genes of inflammation and Crohn’s disease severity identified via bioinformatics and clinical specimen analysis 通过生物信息学和临床标本分析确定炎症和克罗恩病严重程度的关键基因

4区综合性期刊

All Life Pub Date : 2023-09-14 DOI: 10.1080/26895293.2023.2251705

Min Lu, Zhirui Zeng, Yongjian Ling, Qinsong Zhong, Zhiliang Mai, Hua Mao, Qian Wang

{"title":"Key genes of inflammation and Crohn’s disease severity identified via bioinformatics and clinical specimen analysis","authors":"Min Lu, Zhirui Zeng, Yongjian Ling, Qinsong Zhong, Zhiliang Mai, Hua Mao, Qian Wang","doi":"10.1080/26895293.2023.2251705","DOIUrl":"https://doi.org/10.1080/26895293.2023.2251705","url":null,"abstract":"Crohn’s disease (CD) is a nonspecific inflammatory disease of digestive tract with limited known biomarkers. We aimed to identify potential molecules involved in CD severity. Weighted gene co-expression network and differentially expressed gene analyses were used to explore hub genes associated with inflammation and involved in pathological processes of CD in the GSE83448 cohort. The expression and relationship of genes with clinical characteristics in normal and CD intestinal mucosa were validated in GSE208303 and our research cohorts. Five genes related to disease and inflammation were identified in the clinically significant modules that were differentially expressed in healthy controls and CD patients. Among them, solute carrier family 39 member 5 (SLC39A5) expression was reduced in CD tissues compared with that in normal tissues; low SLC39A5 expression was associated with CD-simplifying endoscopic score and stenosis. Furthermore, we broadened the bioinformatic threshold with qRT-PCR verification and western blot, and found that the expressions of cytochrome P450 family 2 subfamily S member 1 (CYP2S1), fatty acid 2-hydroxylase (FA2H), fatty acid binding protein 1 (FABP1), and Rho family GTPase 3 (RND3) were reduced in CD tissues. Therefore, SLC39A5, CYP2S1, FA2H, FABP1, and RND3 may be novel biomarkers for CD and associated with severity.","PeriodicalId":48478,"journal":{"name":"All Life","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134970664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All Life最新文献