Royal Society Open Science最新文献

Passive retention of simulated larvae on coral reefs. 模拟幼虫在珊瑚礁上的被动滞留。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-05-23 eCollection Date: 2025-05-01 DOI: 10.1098/rsos.241708

Jim Greenwood, C J Sun, Christopher Doropoulos, Damian Thomson, Mark Baird, J Porobic, Scott Condie

{"title":"Passive retention of simulated larvae on coral reefs.","authors":"Jim Greenwood, C J Sun, Christopher Doropoulos, Damian Thomson, Mark Baird, J Porobic, Scott Condie","doi":"10.1098/rsos.241708","DOIUrl":"https://doi.org/10.1098/rsos.241708","url":null,"abstract":"The extent to which local coral populations are self-sustaining through local recruitment has important implications for managing coral reef systems. However, a lack of understanding has led to overly simplistic representation of this phenomenon in coral reef population models. In this study, we simulate the dispersal of artificial larvae from 24 selected individual reefs across the Great Barrier Reef, Australia, over a spawning period in December 2016, to identify key physical factors influencing their retention. We found the dispersal pattern of larvae differed depending on whether they are well mixed throughout the water column and transported by depth-averaged velocity or floating near the surface, with well-mixed populations following more circuitous routes and dispersing more slowly. Retention time (Rt ) varies widely between reefs, with most of the variation observed in this study (r 2 = 0.90) explained by reef area (A) represented by the empirical power law relationship Rt = 10.34 A0.65, or alternatively by a combination of reef area and mean water depth ( <math> <mstyle> <mrow><mover><mi>h</mi> <mo>¯</mo></mover> </mrow> </mstyle> </math> ) using the linear relationship Rt = 1.23(A) - 6.38( <math> <mstyle> <mrow><mover><mi>h</mi> <mo>¯</mo></mover> </mrow> </mstyle> </math> ). The formation of tidal eddies and being situated among closely aggregated reefs are shown to be important factors for larval retention. Simple retention relationships like these have the potential to be incorporated into larval connectivity modelling and reef meta-community modelling where reef area and water depth are known. Further research is needed to determine how different oceanographic conditions and interannual variability will affect these relationships.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 5","pages":"241708"},"PeriodicalIF":2.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12105734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144151857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular basis of the explosive defence response in the bombardier beetle Brachinus crepitans. 投弹甲虫爆炸防御反应的分子基础。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-05-21 eCollection Date: 2025-05-01 DOI: 10.1098/rsos.241823

Heiko Vogel, Nicolai Rügen, Natalie Wielsch, Richard M Twyman, Miray Tonk-Rügen, Andreas Vilcinskas

{"title":"Molecular basis of the explosive defence response in the bombardier beetle Brachinus crepitans.","authors":"Heiko Vogel, Nicolai Rügen, Natalie Wielsch, Richard M Twyman, Miray Tonk-Rügen, Andreas Vilcinskas","doi":"10.1098/rsos.241823","DOIUrl":"10.1098/rsos.241823","url":null,"abstract":"Bombardier beetles have evolved a sophisticated and unique chemical defence mechanism involving controlled explosions within their paired defensive glands, producing a hot, benzoquinone-rich defensive spray. The molecular basis of this response is not well characterized. We therefore combined the transcriptomic and proteomic analysis of different gland compartments in the bombardier beetle Brachinus crepitans (Linnaeus, 1758) (Coleoptera, Carabidae) to identify abundant transcripts and gland-specific proteins with key defensive functions, such as catalases, peroxidases and enzymes involved in hydroquinone synthesis. By combining precise dissections with protein sequence analysis, we built a comprehensive atlas of the relevant proteins and their spatio-temporal organization. We found that glucose is important as a stable precursor of hydrogen peroxide and hydroquinone. These chemicals, together with gland-specific peroxidases and catalases, then initiate the explosive defence reaction. We also present evidence that the evolution of explosive secretions involved the functional adaptation of peroxidase genes involving atypical substitutions in otherwise highly conserved protein domains.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 5","pages":"241823"},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors impacting effective altruism: revisiting heuristics and biases in charity in a replication and extension registered report of Baron and Szymanska (2011). 影响有效利他主义的因素：在Baron和Szymanska（2011）的复制和扩展注册报告中重新审视慈善中的启发式和偏见。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-05-21 eCollection Date: 2025-05-01 DOI: 10.1098/rsos.250290

Mannix Chan, Gilad Feldman

{"title":"Factors impacting effective altruism: revisiting heuristics and biases in charity in a replication and extension registered report of Baron and Szymanska (2011).","authors":"Mannix Chan, Gilad Feldman","doi":"10.1098/rsos.250290","DOIUrl":"10.1098/rsos.250290","url":null,"abstract":"Individuals who donate to charity may be affected by various biases and donate inefficiently. In a replication and extension registered report with a US Amazon Mechanical Turk sample using CloudResearch (N = 1403), we replicated studies 1 to 4 in Baron & Szymanska (Baron & Szymanska 2011 In The science of giving: experimental approaches to the study of charity (eds DM Oppenheimer, CY Olivola), pp. 215-235 (doi:10.4324/9780203865972-24)) with extensions on reputation and overhead funding. We found support for the effects of a preference for lower perceived waste (d = 0.70, 95% CI [0.41, 0.99]), lower past costs (d = 0.59, 95% CI [0.16, 1.02]), for the ingroup (d = 0.52, 95% CI [0.47, 0.58]), for having some diversification between charities (d = 0.63, 95% CI [0.47, 0.78] for single projects; d = 1.18, 95% CI [1.00, 1.36] for several projects versus one) and against forced charity (d = 0.29, 95% CI [0.21, 0.37]; nominally replicated, but has caveats regarding validity); as at least four of our five hypotheses were found to replicate, we conclude this as being a successful replication. Extending the replication, we found support for an unexpected preference for anonymity on donation allocation (opposite to our predictions; d = 0.54, 95% CI [0.46, 0.61]), and support for a preference towards paid-for overhead costs on donation allocation (d = 0.60, 95% CI [0.52, 0.68]). We discuss the implications and validity of these findings. All materials, data and code were made available on: https://doi.org/10.17605/OSF.IO/BEP78. This registered report has been officially endorsed by Peer Community in Registered Reports: https://doi.org/10.24072/pci.rr.100775.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 5","pages":"250290"},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the paternal genetic structure and migration history of Chinese Qiang minority by Y-chromosome short tandem repeats. 利用y染色体短串联重复序列研究羌族父系遗传结构和迁移史。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-05-21 eCollection Date: 2025-05-01 DOI: 10.1098/rsos.242046

Guang-Yao Fan, Ying Zhu, En-Na Wang, Tian-Ge Ju

{"title":"Investigating the paternal genetic structure and migration history of Chinese Qiang minority by Y-chromosome short tandem repeats.","authors":"Guang-Yao Fan, Ying Zhu, En-Na Wang, Tian-Ge Ju","doi":"10.1098/rsos.242046","DOIUrl":"10.1098/rsos.242046","url":null,"abstract":"Known for its legendary history and peculiar culture, Chinese Qiang minority aroused interest among geneticists and anthropologists. However, the paternal genetic landscape of its sub-branches coupled with its migration history has never been uncovered. In this study, 37 Y-chromosomal short tandem repeat (Y-STR) loci of three Qiang ethnic groups (N = 564) were investigated to shed light on their paternal genetic landscape. The phylogenetic reconstruction among 29 populations was conducted based on their Y-chromosomal haplotypes. The genetic affinities of the four different Qiang subgroups exhibited obviously variant when compared with Han, Yi or Tibetan in Tibetan-Yi corridor. Based on machine learning method, the predicted Y chromosome haplogroups demonstrated the predominance of O2a1 and O2a2. The haplogroup distributions were compared among 40 contemporary ethnic groups in West China and DNA samples of 214 ancient humans from 59 archaeological sites. The results supported that Wenchuan Qiang had historical links with the ancients in West Liao River (WLR) region. Moreover, intrapopulation gene flow was analysed using Migrate-n. Bidirectional migration was proved to be the most frequent model among the Qiangic populations while the unidirectional migration was only observed from Wenchuan to Li County.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 5","pages":"242046"},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reverse game: from Nash equilibrium to network structure, number and probability of occurrence. 逆向博弈：从纳什均衡到网络结构、数量和发生概率。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-05-21 eCollection Date: 2025-05-01 DOI: 10.1098/rsos.241928

Ali Ebrahimi, Mehdi Sadeghi

{"title":"Reverse game: from Nash equilibrium to network structure, number and probability of occurrence.","authors":"Ali Ebrahimi, Mehdi Sadeghi","doi":"10.1098/rsos.241928","DOIUrl":"10.1098/rsos.241928","url":null,"abstract":"In this paper, we introduce a reverse game approach to network-modelled games to determine the network structure among players that can achieve a desired Nash equilibrium. We consider three types of network games: the majority game, the minority game and the best-shot public goods game. For any proposed Nash equilibrium, we identify the conditions and constraints of the network structure necessary to achieve that equilibrium in each game. Acceptable networks-i.e. networks that satisfy the assumed Nash equilibrium-are not unique, and their numbers grow exponentially based on the number of players and the combination of strategies. We provide mathematical relationships to calculate the exact number of networks that can create the specified Nash equilibrium in the best-shot public goods game. Additionally, in the majority and minority games, the relationships presented under special conditions specify the number of networks. We also investigate the distribution of acceptable networks as microsystems associated with the existing Nash equilibrium and their probability of occurrence. Our simulations indicate that the distribution of acceptable networks according to density follows a normal distribution, and their probability of occurrence increases. In other words, denser networks are more likely to lead to the desired Nash equilibrium.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 5","pages":"241928"},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validating a novel capability of assessing pathways of animal water gain and loss. 验证一种评估动物水分获得和损失途径的新能力。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-05-21 eCollection Date: 2025-05-01 DOI: 10.1098/rsos.241942

Zachary T Steele, Karen Caceres, Zachary A David, Lisa M Shollenberger, Alexander R Gerson, Seth D Newsome, John P Whiteman

{"title":"Validating a novel capability of assessing pathways of animal water gain and loss.","authors":"Zachary T Steele, Karen Caceres, Zachary A David, Lisa M Shollenberger, Alexander R Gerson, Seth D Newsome, John P Whiteman","doi":"10.1098/rsos.241942","DOIUrl":"10.1098/rsos.241942","url":null,"abstract":"Understanding variations in the routes by which wild animals gain and lose water is challenging, and common methods require longitudinal sampling, which can be prohibitive. However, a new approach uses Δ'17OBW (Δ'17O of animal body water), calculated from measurements of δ'17O and δ'18O in a single sample, as a natural tracer of water flux. Δ'17OBW is promising, but its relationship to organismal variables such as metabolic rate and water intake have not been validated. Here, we continuously measured oxygen influxes and effluxes of captive deer mice (Peromyscus maniculatus), and manipulated their water intake and metabolic rate. We used these oxygen flux data to predict Δ'17OBW for the mice and compared these model predictions with Δ'17OBW measured in blood plasma samples. As expected, Δ'17OBW positively correlated with drinking water intake and negatively correlated with metabolic rate. All predicted Δ'17OBW (based on measured oxygen fluxes) values differed from measured Δ'17OBW values by <30 per meg (mean absolute difference: 11 ± 9 per meg), suggesting high accuracy for this modelling approach because studies currently report a range of 300 per meg for Δ'17OBW among mammals, birds and fish.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 5","pages":"241942"},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A complex adaptive systems model of labour reciprocity and normative reasoning in swidden agriculture. 农业劳动互惠和规范推理的复杂适应系统模型。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-05-21 eCollection Date: 2025-05-01 DOI: 10.1098/rsos.242197

Denis Tverskoi, Shane A Scaggs, Sean S Downey

{"title":"A complex adaptive systems model of labour reciprocity and normative reasoning in swidden agriculture.","authors":"Denis Tverskoi, Shane A Scaggs, Sean S Downey","doi":"10.1098/rsos.242197","DOIUrl":"10.1098/rsos.242197","url":null,"abstract":"Swidden (aka 'slash-and-burn') agriculture is a prototypical-coupled human and natural system. Despite this, mathematical models integrating its social and ecological dynamics are rare. Here, we use complex adaptive systems theory to develop a model where individuals rely on labour exchange driven by reciprocity and normative reasoning that can lead to sanctions. Our results identify three emergent regimes: low-intensity swidden, sustainable high-intensity swidden that maximizes ecosystem services and harvest returns, and deforestation. We show that sustainable high-intensity swidden evolves if labour reciprocity and normative reasoning are balanced: helping behaviour should be significantly conditioned by normative reasoning to prevent over-harvesting, while reciprocity is necessary to prevent excessive sanctioning. We find that the sustainable high-intensity swidden regime is robust to changes in group size, is resilient to environmental shocks, can evolve under various models of forest ecology and is most productive for both forests and farmers when the balance of labour reciprocity and normative reasoning results in an intermediate scale of forest disturbance. Overall, we illuminate the importance of Indigenous social norms and customary practices related to swidden labour in maintaining sustainable and intensive swidden agriculture.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 5","pages":"242197"},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the accuracy of palaeobiological modelling procedures in forward-dynamics simulations of maximum-effort vertical jumping. 探索古生物建模程序在最大努力垂直跳跃的前向动力学模拟中的准确性。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-05-21 eCollection Date: 2025-05-01 DOI: 10.1098/rsos.242109

Samuel R R Cross, James P Charles, William I Sellers, Jonathan R Codd, Karl T Bates

{"title":"Exploring the accuracy of palaeobiological modelling procedures in forward-dynamics simulations of maximum-effort vertical jumping.","authors":"Samuel R R Cross, James P Charles, William I Sellers, Jonathan R Codd, Karl T Bates","doi":"10.1098/rsos.242109","DOIUrl":"10.1098/rsos.242109","url":null,"abstract":"The body fossil record cannot preserve the dynamics of animal locomotion, and the only way to systematically reconstruct it is through simulation. However, musculoskeletal models used in simulation studies are typically simplified, meaning that their efficacy must first be demonstrated on living animals. Here, we evaluate a workflow for forward-dynamics simulations of maximum-effort vertical jumping, using simplified human and guineafowl models built with muscle masses from either measured data or estimated with methods previously applied to fossils. Predicted human performance was approximately 10% below experimental averages when known muscle masses were used, while the error ranged between +3 and -10% with palaeobiological methods. The simulations also correctly replicated the kinematic strategies (countermovement or squat jump) used across different starting postures. In contrast, predicted guineafowl performance was around 50-60% experimental values, irrespective of reconstruction method. Guineafowl model underperformance likely reflects simplifications related to foot mobility, muscle activation speeds and muscle fibre lengths, with the latter potentially being adaptively important to exceptional avian jumping performance. These findings emphasize that current muscle reconstruction and simulation approaches are most suited for evolutionary analyses where broad changes in body morphology and posture may significantly impact vertical jumping through pronounced qualitative differences in kinematic strategy.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 5","pages":"242109"},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rebuilding Earth's first skeletal animals: the original morphology of Corumbella (Ediacaran, Brazil). 重建地球上最早的骨骼动物：科伦巴（巴西埃迪卡拉纪）的原始形态。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-05-21 eCollection Date: 2025-05-01 DOI: 10.1098/rsos.250206

Bruno Becker-Kerber, Javier Ortega-Hernández, James D Schiffbauer, Rudy Lerosey-Aubril, Lucas Verissimo Warren, Marcello Guimarães Simões, Lucas Del Mouro, Cristiane Barbieri Rodella, Miguel Angelo Stipp Basei, Nathaly Lopes Archilha

{"title":"Rebuilding Earth's first skeletal animals: the original morphology of Corumbella (Ediacaran, Brazil).","authors":"Bruno Becker-Kerber, Javier Ortega-Hernández, James D Schiffbauer, Rudy Lerosey-Aubril, Lucas Verissimo Warren, Marcello Guimarães Simões, Lucas Del Mouro, Cristiane Barbieri Rodella, Miguel Angelo Stipp Basei, Nathaly Lopes Archilha","doi":"10.1098/rsos.250206","DOIUrl":"10.1098/rsos.250206","url":null,"abstract":"The evolutionary onset of animal biomineralization in the late Ediacaran (ca 555-538 Ma) is marked by the global appearance of enigmatic tubular fossils with unresolved phylogenetic relationships. Among these, Corumbella werneri from the Tamengo Formation (Corumbá Group, Brazil) has been variously interpreted as affiliated with cnidarians or bilaterians. Using synchrotron imaging and machine learning, we analysed new specimens of C. werneri to reconstruct their original skeletal organization. Our findings reveal that Corumbella's tubes were originally conico-cylindrical. Large individuals of Corumbella, including less compacted specimens, and compression experiments with modern annelid tubes all indicate that previous reconstructions of a quadrate outline and midline features were misled by taphonomic artefacts. We also show that the wall of Corumbella is composed of a single layer of ring-shaped elements. Unlike the fourfold symmetry of scyphozoans or the complex cataphract-like structures of Cambrian bilaterians (e.g. halkieriids, tommotiids and wiwaxiids), Corumbella displays structural similarities with other late Ediacaran corumbellomorphs, such as Costatubus. These taxa exhibit a distinctive barrel-on-barrel tube construction, with modular elements stacked on each other rather than nested. Our findings redefine Corumbella's morphology and phylogenetic affinities, contributing to a broader understanding of early biomineralizing metazoans and their ecological roles in the Ediacaran biosphere.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 5","pages":"250206"},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal relationship between gut microbiota, blood metabolites and autism spectrum disorder: a Mendelian randomization study. 肠道菌群、血液代谢物与自闭症谱系障碍的因果关系：一项孟德尔随机研究。

IF 2.9 3区综合性期刊

Royal Society Open Science Pub Date : 2025-05-21 eCollection Date: 2025-05-01 DOI: 10.1098/rsos.250158

Jigan Wang, Hui-Hong Dou, Qiong-You Liang

{"title":"Causal relationship between gut microbiota, blood metabolites and autism spectrum disorder: a Mendelian randomization study.","authors":"Jigan Wang, Hui-Hong Dou, Qiong-You Liang","doi":"10.1098/rsos.250158","DOIUrl":"10.1098/rsos.250158","url":null,"abstract":"This study explored the causal relationships between gut microbiota, blood metabolites and autism spectrum disorder (ASD) in children and assessed whether metabolites mediate the relationship between microbiota and ASD. Using Mendelian randomization (MR), causal links between gut microbiota, blood metabolites and ASD were analysed, alongside reverse MR to examine reverse causality. A two-step MR mediation analysis was used to assess metabolite mediation. The study identified 15 gut microbiota types significantly associated with ASD, with Marinilabiliaceae showing the strongest positive link (odds ratio (OR) = 5.206, 95% confidence interval (CI) = 1.2783-21.2017, p = 0.0213) and Poseidoniaceae the strongest negative association (OR = 0.1466, 95% CI = 0.0306-0.7035, p = 0.0164). Among 52 blood metabolites, 4-methylcatechol sulphate was positively associated with ASD risk (OR = 1.6776, 95% CI = 1.0482-2.6849, p = 0.0311), while the glucose-to-maltose ratio showed a negative relationship (OR = 0.6358). No significant reverse causal effects of ASD on microbiota or metabolites were found. Nine metabolites mediated the relationship between microbiota and ASD, with 1-methyl-5-imidazoleacetate showing the strongest negative mediation effect (mediating effect = -0.0862, mediation proportion = 12.30%). This study reveals complex causal pathways involving microbiota and metabolites in ASD, suggesting metabolites may mediate the microbiota-ASD relationship, offering insights into ASD mechanisms and potential interventions.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"12 5","pages":"250158"},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0