Royal Society Open Science最新文献

Messy eaters and scavenger hunts: the community ecology of scavenging interactions in a rockpool ecosystem. 乱食者和拾荒者：岩池生态系统中拾荒相互作用的群落生态学。

IF 3 3区综合性期刊

Royal Society Open Science Pub Date : 2026-10-28 eCollection Date: 2026-10-07 DOI: 10.1098/rsos.261342

Lola I L Weiss, Charlotte S C Davis, Maddie Doran, Rebecca Gourlay, Leonie Kay, Allison K Puckett, Melissa E Ramsay, Margot Rochelet, Michael M Webster

{"title":"Messy eaters and scavenger hunts: the community ecology of scavenging interactions in a rockpool ecosystem.","authors":"Lola I L Weiss, Charlotte S C Davis, Maddie Doran, Rebecca Gourlay, Leonie Kay, Allison K Puckett, Melissa E Ramsay, Margot Rochelet, Michael M Webster","doi":"10.1098/rsos.261342","DOIUrl":"https://doi.org/10.1098/rsos.261342","url":null,"abstract":"Carcasses are valuable resources to those scavengers able to access them. While some generalist foragers are poorly equipped to process carcasses themselves, they may exploit the actions of others by feeding on tissues that the latter expose or detach. Carcasses also attract opportunistic predators, which can target other smaller scavengers, as well as feeding on the carcass itself. We studied these interactions using field-based experiments in a rockpool ecosystem. First, we showed that greater numbers of small fishes and mysids were attracted to areas where scavengers, primarily hermit crabs (Pagurus bernhardus), were feeding on mussel carcass baits compared to treatments where inaccessible carcasses or no-carcass controls were presented. We termed these secondary scavengers, since we did not see them feeding on the carcass directly. Second, we saw predators attack scavengers more frequently in trials where carcasses were present than where they were absent. They also approached stimulus chambers containing aggregations of hermit crabs more often than empty controls. Nonetheless, predator interactions were, overall, infrequent. For these smaller scavengers, carcass-foraging may be a trade-off between access to a sizeable food resource and competition, and sometimes heightened predation risk, from larger scavengers.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"13 10","pages":"261342"},"PeriodicalIF":3.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149300006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmentally friendly novel macromolecular leveller imidazole-pentaerythritol glycidyl ether with high electroplating performance. 具有高电镀性能的新型环保大分子整平剂咪唑-季戊四醇缩水甘油酯。

IF 3 3区综合性期刊

Royal Society Open Science Pub Date : 2026-10-28 eCollection Date: 2026-10-07 DOI: 10.1098/rsos.261181

Shoulong Zhang, David W Zhang

{"title":"Environmentally friendly novel macromolecular leveller imidazole-pentaerythritol glycidyl ether with high electroplating performance.","authors":"Shoulong Zhang, David W Zhang","doi":"10.1098/rsos.261181","DOIUrl":"https://doi.org/10.1098/rsos.261181","url":null,"abstract":"In this study, a novel environmentally friendly leveller, imidazole-pentaerythritol glycidyl ether (IMDPGE), which is free of sulfur (S) and other pollutant elements, was developed by chemical synthesis for blind-hole filling in acidic copper electroplating. The chemical structure of IMDPGE was characterized using Fourier transform infrared spectroscopy and mass spectrometry. The molecular properties of IMDPGE were investigated through quantum chemical calculations and molecular dynamics simulations, and its levelling performance was predicted accordingly. The electrochemical characteristics of IMDPGE, as well as its interactions with the accelerator bis-(3-sulfopropyl) disulfide (SPS) and the suppressor propyleneoxide (PO)-ethylene oxide (EO)-propylene oxide (PO), named PEP (EPE), were evaluated using galvanostatic potential transient measurements, cyclic voltammetry and linear scan voltammetry. The results demonstrated that IMDPGE exhibited strong polarization capability, which persisted even in the absence of SPS. Additionally, a kinetically controlled competitive adsorption existed between IMDPGE and SPS, while a synergistic inhibitory effect was observed between IMDPGE and EPE. The blind-hole filling performance of IMDPGE was verified through electroplating experiments. For the optimized EPE-SPS-IMDPGE additive system, a filling rate of 90.7% and a surface copper thickness of 7.7 µm were achieved after electroplating at a current density of 2 A dm-² for 30 minutes.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"13 10","pages":"261181"},"PeriodicalIF":3.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149300030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Smart insect trap: insect identification and classification using iNaturalist and ChatGPT. 智能捕虫器：利用iNaturalist和ChatGPT对昆虫进行识别和分类。

IF 3 3区综合性期刊

Royal Society Open Science Pub Date : 2026-10-28 eCollection Date: 2026-10-07 DOI: 10.1098/rsos.251212

Yuhan Wu, Anthony Nicolaides, Anthony Coffin-Schmitt, Sunghwan Jung

{"title":"Smart insect trap: insect identification and classification using iNaturalist and ChatGPT.","authors":"Yuhan Wu, Anthony Nicolaides, Anthony Coffin-Schmitt, Sunghwan Jung","doi":"10.1098/rsos.251212","DOIUrl":"https://doi.org/10.1098/rsos.251212","url":null,"abstract":"Insect identification is crucial for sustainable agriculture and pest control, as it helps determine the pest type, reduces human labour, and decreases reliance on pesticides. However, there are a number of challenges associated with AI-based insect identification and classification, such as the lack of reliable data sources, imbalanced datasets and difficulty of annotation. Our paper offers a practical solution to these challenges using online platforms. Specifically, we coordinate multiple AI tools in an agentic-AI-style workflow: iNaturalist's computer vision model identifies the insect, ChatGPT determines whether it is a pest and the result drives a low-cost robotic trap. This approach is particularly accessible for non-experts, as it does not require extensive knowledge of machine learning or computer vision, and each component can be upgraded as better AI tools emerge. The system was further validated through field testing using images collected under real agricultural conditions. The results show our method is able to identify and differentiate insect species with sufficient accuracy. Our approach would be more accessible, reliable and efficient than traditional methods and can be used to identify a wider range of insect species.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"13 10","pages":"251212"},"PeriodicalIF":3.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149300129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baleen reveals sex-specific foraging, reproduction and pregnancy endocrinology in sei whales. 鲸须揭示了鲸鱼的性别特异性觅食、繁殖和怀孕内分泌。

IF 3 3区综合性期刊

Royal Society Open Science Pub Date : 2026-10-28 eCollection Date: 2026-10-07 DOI: 10.1098/rsos.261471

Daniela Magalhaes Drummond de Mello, Alejandro A Fernandez Ajó, Lilian Reiss, Kathleen Hunt, Matthew C Rogers, Danielle Dillon, Faith M Walker, Anna Riley, Daniel E Sanchez, Christoph Mayr, Vreni Häussermann, Keri-Lee Pashuk, Matthew R Coyle, Fernando Ribeiro Gomes, C Loren Buck

{"title":"Baleen reveals sex-specific foraging, reproduction and pregnancy endocrinology in sei whales.","authors":"Daniela Magalhaes Drummond de Mello, Alejandro A Fernandez Ajó, Lilian Reiss, Kathleen Hunt, Matthew C Rogers, Danielle Dillon, Faith M Walker, Anna Riley, Daniel E Sanchez, Christoph Mayr, Vreni Häussermann, Keri-Lee Pashuk, Matthew R Coyle, Fernando Ribeiro Gomes, C Loren Buck","doi":"10.1098/rsos.261471","DOIUrl":"https://doi.org/10.1098/rsos.261471","url":null,"abstract":"The largest baleen whale mortality event on record, when more than 340 sei whales (Balaenoptera borealis) stranded in Chilean Patagonia during the extreme 2015 El Niño, provided a unique opportunity to reconstruct multi-year individual life histories from baleen plates. Baleens of seven females and four males were sampled to examine sex-specific foraging strategies, reproductive cycles and endocrine patterns through integrated molecular, isotopic and hormonal analyses. Sex was identified using a refined DNA amplification protocol. Patterns of δ 13C and δ 15N revealed significant annual oscillations, enabling estimates of baleen growth rates (15.7-20.5 cm yr-1) and retrospective timelines of up to 3.5 years. Males exhibited broader isotopic niche widths, suggesting sex-related foraging differences. Progesterone was detected in all samples, with sustained elevations in females indicating pregnancies of 7.7-10.7 months. One female exhibited two complete pregnancies recorded in baleen, enabling estimation of a 1.3-year intercalving interval. Concurrent elevations of cortisol and corticosterone were observed during pregnancy. Conceptions and births were distributed across multiple seasons, with no clear evidence of seasonal concentration. Together, these findings provide the first baleen-based reconstruction of sei whale reproductive history and endocrine variation, establishing critical baselines for assessing population resilience and informing conservation under rapid environmental change.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"13 10","pages":"261471"},"PeriodicalIF":3.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149300282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Latent variable modelling of condition and reproductive investment in Gryllus vocalis field crickets. 野蟋蟀状态和生殖投资的潜变量模型。

IF 3 3区综合性期刊

Royal Society Open Science Pub Date : 2026-10-28 eCollection Date: 2026-10-07 DOI: 10.1098/rsos.261085

Madison Von Deylen, Agustí Muñoz-Garcia, Ian M Hamilton, Susan N Gershman

{"title":"Latent variable modelling of condition and reproductive investment in Gryllus vocalis field crickets.","authors":"Madison Von Deylen, Agustí Muñoz-Garcia, Ian M Hamilton, Susan N Gershman","doi":"10.1098/rsos.261085","DOIUrl":"https://doi.org/10.1098/rsos.261085","url":null,"abstract":"'Condition' is often used to describe the underlying state or quality of an individual and is expected to influence traits essential for fitness. Variation in condition is therefore expected to contribute to differences in reproductive investment. However, both condition and reproductive investment are complex and multi-dimensional, making them difficult to quantify comprehensively. Instead, they are typically inferred using measurable traits, which may capture only limited aspects of these constructs. Herein, we use structural equation modelling to integrate multiple proxy measurements, quantify the influence of underlying condition and reproductive investment on proxies and examine the relationship between condition and reproductive investment. Using Gryllus vocalis field crickets, we constructed sex-specific models to account for differences in reproductive strategies and trait expression between males and females. Both models identified proxies that were significantly influenced by condition and reproductive investment, although the strength of this influence varied across traits, suggesting that some proxies are better indicators than others. Both models also revealed significant positive relationships between condition and reproductive investment. Overall, our results demonstrate that condition positively influences reproductive investment, while revealing that commonly used proxies vary in how well they reflect these underlying constructs.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"13 10","pages":"261085"},"PeriodicalIF":3.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149300069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sailing to Gondwana: multiple waves of spinosaurid dispersal to the southern continents. 航行到冈瓦纳：多波棘龙散布到南部大陆。

IF 3 3区综合性期刊

Royal Society Open Science Pub Date : 2026-10-28 eCollection Date: 2026-10-07 DOI: 10.1098/rsos.260994

Zak E Lewis, Charlie R Scherer, Tom T P van der Linden, Paul J Byrne, Bethany Burke, Colin Boisvert, Ezekiel V O'Callaghan, Kenneth C Rayburn, Robert Mayer, Chance Guest, Harry T Jones, Tristan Moran, Steven J R Allain, Cassius Morrison

{"title":"Sailing to Gondwana: multiple waves of spinosaurid dispersal to the southern continents.","authors":"Zak E Lewis, Charlie R Scherer, Tom T P van der Linden, Paul J Byrne, Bethany Burke, Colin Boisvert, Ezekiel V O'Callaghan, Kenneth C Rayburn, Robert Mayer, Chance Guest, Harry T Jones, Tristan Moran, Steven J R Allain, Cassius Morrison","doi":"10.1098/rsos.260994","DOIUrl":"https://doi.org/10.1098/rsos.260994","url":null,"abstract":"Spinosaurid theropods exhibited a relatively widespread distribution during the Cretaceous Period; however, biogeographical analyses have been limited, largely owing to their fragmentary nature and uncertainties in spinosaurid phylogeny. We conducted a biogeographical analysis of Megalosauroidea, with a focus on Spinosauridae, using the R package 'BioGeoBEARS' on multiple phylogenetic trees to test their probable dispersal patterns. The best-fit models suggest that spinosaurid evolutionary history was influenced by geodispersal followed by narrow and widespread vicariance, as well as regional sympatry between co-occurring taxa. Within Spinosauridae, we find at least two distinct dispersals from Europe into Africa and South America, as well as at least one dispersal from Europe into Asia. Based on existing climate model data, spinosaurids generally appear to occur in high mean annual temperature semi-aquatic environments (approx. 26.1-33.1°C) with relatively minimal seasonal variation (approx. ±8.46°C), which may have influenced their dispersal capability, as these preferences appearmore constrained compared with those of other medium-to-large theropods. These results imply a more limited biogeographical distribution for Spinosauridae compared with other clades, which may be owing to climatic dispersal barriers and environmental factors.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"13 10","pages":"260994"},"PeriodicalIF":3.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149300176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteohistological analysis reveals unusual bone tissue patterns in Temminck's ground pangolin (Smutsia temminckii). 骨组织学分析揭示了Temminck地穿山甲（Smutsia temminckii）不寻常的骨组织模式。

IF 3 3区综合性期刊

Royal Society Open Science Pub Date : 2026-10-28 eCollection Date: 2026-10-07 DOI: 10.1098/rsos.261533

Palesa Mamabolo, Francesca Parrini, Jennifer Botha

{"title":"Osteohistological analysis reveals unusual bone tissue patterns in Temminck's ground pangolin (Smutsia temminckii).","authors":"Palesa Mamabolo, Francesca Parrini, Jennifer Botha","doi":"10.1098/rsos.261533","DOIUrl":"https://doi.org/10.1098/rsos.261533","url":null,"abstract":"Temminck's ground pangolin is one of Africa's most threatened mammals, yet little is known about its skeletal biology. This study provides the first osteohistological analysis of its limb bones, documenting patterns of growth, remodelling and skeletal reinforcement. Limb bones exhibit extensive cortical remodelling, with substantial portions of the cortex being composed of compacted coarse cancellous bone, endosteal bone and secondary osteons, together with abundant resorption cavities. Growth marks occur in all elements, but the absence of outer circumferential lamellae and persistence of open vascular canals indicate continued growth and a lack of skeletal maturity despite the presence of up to four annual growth cycles. Extensive skeletal reinforcement occurs throughout the limbs, although elements employ distinct osteohistological patterns. Comparison with the aardvark reveals alternative pathways of skeletal reinforcement, with ground pangolins showing relatively greater secondary remodelling in the hind limb. Ground pangolins are further distinguished by abundant, incompletely infilled resorption cavities extending into the middle and outer cortex, suggesting an unusual pattern of intracortical remodelling. The exceptionally low basal metabolic rate of S. temminckii may contribute to these patterns, although this relationship remains to be tested. These findings provide new insights into the skeletal biology of this poorly studied mammal.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"13 10","pages":"261533"},"PeriodicalIF":3.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149300189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can you feel meaning? Spirituality involves stronger sensorimotor associations with abstract concepts. 你能感觉到意义吗？灵性涉及到与抽象概念更强的感觉运动联系。

IF 3 3区综合性期刊

Royal Society Open Science Pub Date : 2026-10-28 eCollection Date: 2026-10-07 DOI: 10.1098/rsos.260997

Natalia Zarzeczna, Travis Proulx, Brian Meier, Eva Gutierrez-Sigut

{"title":"Can you feel meaning? Spirituality involves stronger sensorimotor associations with abstract concepts.","authors":"Natalia Zarzeczna, Travis Proulx, Brian Meier, Eva Gutierrez-Sigut","doi":"10.1098/rsos.260997","DOIUrl":"https://doi.org/10.1098/rsos.260997","url":null,"abstract":"Understanding abstract phenomena is a fundamental human need. Emerging evidence increasingly points to the multidimensionality of abstract knowledge representations, with theories emphasizing the importance of both embodied and linguistic influences. In the present paper, we argue that the strength with which embodiment is associated with abstract concepts is moderated by cultural beliefs about ontological meaning. Specifically, we predicted that self-identified spirituality-a belief system guided by an experiential approach to understanding reality-contributes to greater sensorimotor associations with abstract concepts. As hypothesized, across four studies (n = 729; in the USA and the UK), Western spiritual beliefs involved stronger sensorimotor associations for highly abstract compared to concrete concepts. Importantly, religious beliefs that conceptually overlap with spirituality did not contribute to these associations. Altogether, individual differences in belief systems guide people's conscious attendance to sensorimotor features when thinking about abstract concepts, with spiritual individuals likely feeling the meaning of words through linking abstract thought with bodily experiences.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"13 10","pages":"260997"},"PeriodicalIF":3.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149300217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Qualitative study reveals perceived barriers and facilitators of preregistration in animal research. 定性研究揭示了动物研究中预注册的障碍和促进因素。

IF 3 3区综合性期刊

Royal Society Open Science Pub Date : 2026-10-28 eCollection Date: 2026-10-07 DOI: 10.1098/rsos.261156

Cristina Priboi, Simone M Lalor, Evie Vergauwe, Bernice Elger, Hanno Würbel

{"title":"Qualitative study reveals perceived barriers and facilitators of preregistration in animal research.","authors":"Cristina Priboi, Simone M Lalor, Evie Vergauwe, Bernice Elger, Hanno Würbel","doi":"10.1098/rsos.261156","DOIUrl":"https://doi.org/10.1098/rsos.261156","url":null,"abstract":"Preregistration-the prospective registration of hypotheses, methods and analyses plans-is a promising tool in promoting transparency, rigour and reproducibility in science. However, its adoption remains low, particularly in animal research, and little is known about factors influencing its uptake. We explored researchers' experiences and views on preregistration, identifying perceived facilitators and barriers, and gathering suggestions to improve its use. Within a larger cross-sectional mixed-methods project, semi-structured interviews were conducted with 30 Swiss-based researchers involved in animal research and thematically analysed independently by two researchers. Preregistration was described as uncommon in animal research, with views varying by prior experience. Researchers with preregistration experience reported more positive views, whereas those without were more critical. Main barriers included administrative burden, time constraints, limited flexibility and perceived incompatibility with exploratory research. Reported benefits comprised improved study planning, adherence to good research practices and increased transparency. Suggestions to improve uptake involved training, institutional support, integration with the existing authorization procedure and maintaining voluntary participation. Preregistration in animal research remains uncommon and is shaped by prior experience. Addressing barriers through training, institutional support and structural integration may broaden its adoption.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"13 10","pages":"261156"},"PeriodicalIF":3.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149300131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Liouville dynamical modelling and control framework for oesophageal cancer-induced immune response. 食管癌诱导免疫反应的Liouville动力学建模和控制框架。

IF 3 3区综合性期刊

Royal Society Open Science Pub Date : 2026-10-28 eCollection Date: 2026-10-07 DOI: 10.1098/rsos.261866

Souvik Roy, Naif Abu Qarnayn, Mesfer H F Alajmi, Asma Alghamdi, Ibrahem Alshaoosh, Shreshtha Chaturvedi, Olusola Dehinsilu, Rodina El-Adawy, Darsh Gandhi, DeAnna Patterson, Jordan Rodriguez

{"title":"A Liouville dynamical modelling and control framework for oesophageal cancer-induced immune response.","authors":"Souvik Roy, Naif Abu Qarnayn, Mesfer H F Alajmi, Asma Alghamdi, Ibrahem Alshaoosh, Shreshtha Chaturvedi, Olusola Dehinsilu, Rodina El-Adawy, Darsh Gandhi, DeAnna Patterson, Jordan Rodriguez","doi":"10.1098/rsos.261866","DOIUrl":"https://doi.org/10.1098/rsos.261866","url":null,"abstract":"A Liouville-based framework is developed for optimizing treatment strategies in oesophageal cancer (OC) while accounting for inter-patient heterogeneity. Variability within a patient cohort is represented through uncertain initial cancer and immune cell populations, whose probability distribution is propagated by a Liouville partial differential equation while the underlying individual dynamics remains deterministic. Two optimization problems are considered. First, model parameters are estimated from population-level data using an adjoint-based projected nonlinear conjugate-gradient (NCG) method. Second, optimal time-dependent combinations of chemotherapy and immunotherapy are determined using a sequential quadratic Hamiltonian (SQH) scheme based on Pontryagin's maximum principle (PMP). The Liouville equation is discretized using a finite-volume method designed to preserve positivity and conservation of the probability density. Numerical experiments with synthetic population data are used to demonstrate the parameter-estimation framework and the ability of the proposed optimal control strategy to determine treatment protocols that effectively modify the population-level cancer-immune response while limiting treatment exposure.","PeriodicalId":21525,"journal":{"name":"Royal Society Open Science","volume":"13 10","pages":"261866"},"PeriodicalIF":3.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149300204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0