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Lab mice can now have periods like humans. 实验室老鼠现在可以像人类一样有月经了。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-10-23 DOI: 10.1126/science.aed2824
Holly Barker
{"title":"Lab mice can now have periods like humans.","authors":"Holly Barker","doi":"10.1126/science.aed2824","DOIUrl":"https://doi.org/10.1126/science.aed2824","url":null,"abstract":"Studies of rodents with a menstrual on/off switch could help people with endometriosis and other disorders.","PeriodicalId":21678,"journal":{"name":"Science","volume":"93 1","pages":"322-323"},"PeriodicalIF":56.9,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A better recipe for generating immune peacemakers. 一个更好的方法来产生免疫的和平缔造者。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-10-23 DOI: 10.1126/science.aed2827
Catherine Offord
{"title":"A better recipe for generating immune peacemakers.","authors":"Catherine Offord","doi":"10.1126/science.aed2827","DOIUrl":"https://doi.org/10.1126/science.aed2827","url":null,"abstract":"Nobel laureate develops new method of making regulatory T cells that could treat autoimmune conditions.","PeriodicalId":21678,"journal":{"name":"Science","volume":"3 1","pages":"326"},"PeriodicalIF":56.9,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interstellar visitors: Smoking and nonsmoking 星际访客：吸烟和非吸烟
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-23 DOI: 10.1126/science.aec2085
Andy Lawrence
{"title":"Interstellar visitors: Smoking and nonsmoking","authors":"Andy Lawrence","doi":"10.1126/science.aec2085","DOIUrl":"10.1126/science.aec2085","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6771","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Calcifying plankton: From biomineralization to global change 浮游生物钙化：从生物矿化到全球变化
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-23 DOI: 10.1126/science.adq8520
Patrizia Ziveri, Gerald Langer, Sonia Chaabane, Joost de Vries, William Robert Gray, Nina Keul, Ian A. Hatton, Clara Manno, Richard Norris, Sven Pallacks, Jeremy R. Young, Ralf Schiebel, Stergios Zarkogiannis, Griselda Anglada-Ortiz, Stefania Bianco, Thibault de Garidel-Thoron, Michaël Grelaud, Arturo Lucas, Ian Probert, P. Graham Mortyn
{"title":"Calcifying plankton: From biomineralization to global change","authors":"Patrizia Ziveri,&nbsp;Gerald Langer,&nbsp;Sonia Chaabane,&nbsp;Joost de Vries,&nbsp;William Robert Gray,&nbsp;Nina Keul,&nbsp;Ian A. Hatton,&nbsp;Clara Manno,&nbsp;Richard Norris,&nbsp;Sven Pallacks,&nbsp;Jeremy R. Young,&nbsp;Ralf Schiebel,&nbsp;Stergios Zarkogiannis,&nbsp;Griselda Anglada-Ortiz,&nbsp;Stefania Bianco,&nbsp;Thibault de Garidel-Thoron,&nbsp;Michaël Grelaud,&nbsp;Arturo Lucas,&nbsp;Ian Probert,&nbsp;P. Graham Mortyn","doi":"10.1126/science.adq8520","DOIUrl":"10.1126/science.adq8520","url":null,"abstract":"<div >The cycling of calcium carbonate (CaCO<sub>3</sub>) in the ocean is closely linked to seawater alkalinity and the regulation of atmospheric CO<sub>2</sub>. In the modern pelagic ocean, almost all CaCO<sub>3</sub> is produced by three groups of calcifying planktonic organisms: coccolithophores, foraminifers, and shelled pteropods. In this Review, we examine the differences in functional traits that define each group’s distinctive role in the global carbon cycle and their sensitivity to climate change and ocean acidification. This synthesis reveals that a single representation of CaCO<sub>3</sub> in climate models is unlikely to accurately reflect system dynamics or their impacts on biogeochemical cycling under climate change. We argue that understanding past and future CaCO<sub>3</sub> cycle requires a better delineation of the traits that make up the diversity of calcifying plankton groups.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6771","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucosylation of endogenous haustorium-inducing factors underpins kin avoidance in parasitic plants 内源性吸器诱导因子的糖基化支持寄生植物的皮肤避免
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-23 DOI: 10.1126/science.adx8220
Lei Xiang, Songkui Cui, Simon B. Saucet, Moe Takahashi, Shoko Inaba, Bing Xie, Mario Schilder, Shota Shimada, Mengqi Cui, Yanmei Li, Mutsumi Watanabe, Yuki Tobimatsu, Harro J. Bouwmeester, Takayuki Tohge, Ken Shirasu, Satoko Yoshida
{"title":"Glucosylation of endogenous haustorium-inducing factors underpins kin avoidance in parasitic plants","authors":"Lei Xiang,&nbsp;Songkui Cui,&nbsp;Simon B. Saucet,&nbsp;Moe Takahashi,&nbsp;Shoko Inaba,&nbsp;Bing Xie,&nbsp;Mario Schilder,&nbsp;Shota Shimada,&nbsp;Mengqi Cui,&nbsp;Yanmei Li,&nbsp;Mutsumi Watanabe,&nbsp;Yuki Tobimatsu,&nbsp;Harro J. Bouwmeester,&nbsp;Takayuki Tohge,&nbsp;Ken Shirasu,&nbsp;Satoko Yoshida","doi":"10.1126/science.adx8220","DOIUrl":"10.1126/science.adx8220","url":null,"abstract":"<div >Parasitic plants rarely attack themselves, suggesting the existence of a kin-avoidance mechanism. In the root parasitic plant <i>Phtheirospermum japonicum</i>, prehaustorium formation is triggered by host-secreted haustorium-inducing factors (HIFs), but it is unresponsive to its own exudates. Here we report the identification of the <i>spontaneous prehaustorium 1</i> (<i>spoh1</i>) mutant, which forms prehaustoria without external host signals. <i>spoh1</i> harbors a point mutation in the gene encoding uridine diphosphate–glucosyltransferase UGT72B1, an enzyme that glucosylates and thereby inactivates phenolic HIFs. PjUGT72B1 has a different substrate specificity than its ortholog of the host <i>Arabidopsis</i>. Introduction of PjUGT72B1 into <i>Arabidopsis</i> reduced prehaustorium induction activity, indicating that UGT72B1 regulates haustorium induction by hosts. Our findings suggest that Orobanchaceae hemiparasitic plants have evolved kin-avoidance mechanisms through the glucosylation of endogenous HIFs.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6771","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stranded coral boulders point to a medieval tsunami in the Caribbean. 搁浅的珊瑚巨石表明加勒比海曾发生过中世纪的海啸。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-10-23 DOI: 10.1126/science.aed2825
Katherine Kornei
{"title":"Stranded coral boulders point to a medieval tsunami in the Caribbean.","authors":"Katherine Kornei","doi":"10.1126/science.aed2825","DOIUrl":"https://doi.org/10.1126/science.aed2825","url":null,"abstract":"Study pinpoints likely date for a massive earthquake on the Puerto Rico Trench-and highlights an underappreciated regional hazard.","PeriodicalId":21678,"journal":{"name":"Science","volume":"108 1","pages":"324"},"PeriodicalIF":56.9,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Halt China’s waste incinerator expansion 停止中国垃圾焚烧厂的扩建
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-23 DOI: 10.1126/science.aea3724
Xinhui Feng, Yan Li, Siyu Huang, Feng Li
{"title":"Halt China’s waste incinerator expansion","authors":"Xinhui Feng,&nbsp;Yan Li,&nbsp;Siyu Huang,&nbsp;Feng Li","doi":"10.1126/science.aea3724","DOIUrl":"10.1126/science.aea3724","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6771","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145342036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New head of NIH institute has close ties to JD Vance. 美国国立卫生研究院的新院长与JD Vance关系密切。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-10-23 DOI: 10.1126/science.aed2826
Jocelyn Kaiser
{"title":"New head of NIH institute has close ties to JD Vance.","authors":"Jocelyn Kaiser","doi":"10.1126/science.aed2826","DOIUrl":"https://doi.org/10.1126/science.aed2826","url":null,"abstract":"Unusual hiring process raises concerns about political favoritism.","PeriodicalId":21678,"journal":{"name":"Science","volume":"10 1","pages":"325"},"PeriodicalIF":56.9,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145351756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unsaturated fat alters clock phosphorylation to align rhythms to the season in mice 不饱和脂肪改变生物钟磷酸化，使小鼠的节律与季节保持一致
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-23 DOI: 10.1126/science.adp3065
Daniel C. Levine, Rasmus H. Reeh, Thomas McMahon, Thomas Mandrup-Poulsen, Ying-Hui Fu, Louis J. Ptáček
{"title":"Unsaturated fat alters clock phosphorylation to align rhythms to the season in mice","authors":"Daniel C. Levine,&nbsp;Rasmus H. Reeh,&nbsp;Thomas McMahon,&nbsp;Thomas Mandrup-Poulsen,&nbsp;Ying-Hui Fu,&nbsp;Louis J. Ptáček","doi":"10.1126/science.adp3065","DOIUrl":"10.1126/science.adp3065","url":null,"abstract":"<div >The circadian clock maintains synchrony between biological processes and light/dark cycles by integrating environmental cues. How the clock adapts to seasonal variations in the environment is incompletely understood. We found that a high-fat diet increased phosphorylation of the clock protein PERIOD2 (PER2) on serine 662 (S662), which was necessary and sufficient for regulating phase shifting of daily locomotor activity to entrain to seasonal light cycles. PER2-S662 phosphorylation correlated with genome-wide expression pathways that regulate polyunsaturated fatty acid (PUFA) conversion into oxylipins in the hypothalamus. Partial hydrogenation of dietary PUFAs increased hypothalamic PER2-S662 phosphorylation and entrainment to a summer photoperiod in control mice, but not in mice for which PER2-S662 could not be phosphorylated. PER2-S662 phosphorylation is influenced by, and alters the regulation of, unsaturated fat to control circadian phase shifting across the seasons.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6771","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robust epitaxy of single-crystal transition-metal dichalcogenides on lanthanum-passivated sapphire 镧钝化蓝宝石上过渡金属二硫化物单晶的稳健性外延
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-23 DOI: 10.1126/science.aea0849
Xilu Zou, Yuanyuan Zhao, Dongxu Fan, Shengqiang Wu, Yushu Wang, Caiqi Zou, Yuliang Bian, Lei Liu, Lang Wu, Zhoushuo Han, Wenjie Sun, Yuefeng Nie, Junfeng Gao, Shitong Zhu, Yi Shi, Taotao Li, Feng Ding, Xinran Wang
{"title":"Robust epitaxy of single-crystal transition-metal dichalcogenides on lanthanum-passivated sapphire","authors":"Xilu Zou,&nbsp;Yuanyuan Zhao,&nbsp;Dongxu Fan,&nbsp;Shengqiang Wu,&nbsp;Yushu Wang,&nbsp;Caiqi Zou,&nbsp;Yuliang Bian,&nbsp;Lei Liu,&nbsp;Lang Wu,&nbsp;Zhoushuo Han,&nbsp;Wenjie Sun,&nbsp;Yuefeng Nie,&nbsp;Junfeng Gao,&nbsp;Shitong Zhu,&nbsp;Yi Shi,&nbsp;Taotao Li,&nbsp;Feng Ding,&nbsp;Xinran Wang","doi":"10.1126/science.aea0849","DOIUrl":"10.1126/science.aea0849","url":null,"abstract":"<div >Two-dimensional (2D) transition-metal dichalcogenide (TMDC) semiconductors are promising materials for beyond-silicon electronics, but the growth of single-crystalline TMDCs has been limited to small wafer sizes in laboratory settings. We report the epitaxy of 150-millimeter single-crystalline TMDC wafers on lanthanum-passivated <i>c</i>-plane sapphire. The single atomic layer of lanthanum reduces the surface symmetry and increases the energy difference between antiparallel domains by as much as 200 times, leading to unidirectional domain alignment. We grew single-crystalline molybdenum disulfide (MoS<sub>2</sub>), molybdenum diselenide (MoSe<sub>2</sub>), tungsten disulfide (WS<sub>2</sub>), and tungsten diselenide (WSe<sub>2</sub>) by means of both chemical vapor deposition (CVD) and metal-organic CVD processes. Wafer-scale spectroscopies and device measurements demonstrate the exceptional quality and uniformity of 150-millimeter TMDCs, with average mobility of 110 and 131 square centimeters per volt per second for MoS<sub>2</sub> and WSe<sub>2</sub>, respectively, at room temperature.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6771","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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