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Preprint on Alzheimer's drug deaths ignites author dispute. 关于阿尔茨海默氏症药物致死的预印本引发作者争议。
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-11-15 Epub Date: 2024-11-14 DOI: 10.1126/science.adu5824
Jennifer Couzin-Frankel
{"title":"Preprint on Alzheimer's drug deaths ignites author dispute.","authors":"Jennifer Couzin-Frankel","doi":"10.1126/science.adu5824","DOIUrl":"10.1126/science.adu5824","url":null,"abstract":"<p><p>Co-authors say preliminary data on lecanemab fatalities don't support the paper's claims.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"717-718"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trump won. Is NIH in for a major shake-up? 特朗普获胜。美国国立卫生研究院（NIH）将面临重大调整吗？
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-11-15 Epub Date: 2024-11-14 DOI: 10.1126/science.adu5821
Jocelyn Kaiser
{"title":"Trump won. Is NIH in for a major shake-up?","authors":"Jocelyn Kaiser","doi":"10.1126/science.adu5821","DOIUrl":"10.1126/science.adu5821","url":null,"abstract":"<p><p>Congress might serve as a bulwark, but some changes may be coming.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"713-714"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A glutamine metabolic switch supports erythropoiesis 谷氨酰胺代谢开关支持红细胞生成
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-11-15 DOI: 10.1126/science.adh9215
Junhua Lyu, Zhimin Gu, Yuannyu Zhang, Hieu S. Vu, Christophe Lechauve, Feng Cai, Hui Cao, Julia Keith, Valentina Brancaleoni, Francesca Granata, Irene Motta, Maria Domenica Cappellini, Lily Jun-Shen Huang, Ralph J. DeBerardinis, Mitchell J. Weiss, Min Ni, Jian Xu
{"title":"A glutamine metabolic switch supports erythropoiesis","authors":"Junhua Lyu,&nbsp;Zhimin Gu,&nbsp;Yuannyu Zhang,&nbsp;Hieu S. Vu,&nbsp;Christophe Lechauve,&nbsp;Feng Cai,&nbsp;Hui Cao,&nbsp;Julia Keith,&nbsp;Valentina Brancaleoni,&nbsp;Francesca Granata,&nbsp;Irene Motta,&nbsp;Maria Domenica Cappellini,&nbsp;Lily Jun-Shen Huang,&nbsp;Ralph J. DeBerardinis,&nbsp;Mitchell J. Weiss,&nbsp;Min Ni,&nbsp;Jian Xu","doi":"10.1126/science.adh9215","DOIUrl":"10.1126/science.adh9215","url":null,"abstract":"<div >Metabolic requirements vary during development, and our understanding of how metabolic activity influences cell specialization is incomplete. Here, we describe a switch from glutamine catabolism to synthesis required for erythroid cell maturation. Glutamine synthetase (GS), one of the oldest functioning genes in evolution, is activated during erythroid maturation to detoxify ammonium generated from heme biosynthesis, which is up-regulated to support hemoglobin production. Loss of GS in mouse erythroid precursors caused ammonium accumulation and oxidative stress, impairing erythroid maturation and recovery from anemia. In β-thalassemia, GS activity is inhibited by protein oxidation, leading to glutamate and ammonium accumulation, whereas enhancing GS activity alleviates the metabolic and pathological defects. Our findings identify an evolutionarily conserved metabolic adaptation that could potentially be leveraged to treat common red blood cell disorders.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":""},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'America first' could affect health worldwide. 美国优先 "可能会影响全世界的健康。
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-11-15 Epub Date: 2024-11-14 DOI: 10.1126/science.adu5822
Gretchen Vogel
{"title":"'America first' could affect health worldwide.","authors":"Gretchen Vogel","doi":"10.1126/science.adu5822","DOIUrl":"10.1126/science.adu5822","url":null,"abstract":"<p><p>Scientists worry Donald Trump will leave WHO again and slash disease control programs.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"715"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Russia postpones three scientific 'megaprojects'. 俄罗斯推迟三个科学 "巨型项目"。
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-11-15 Epub Date: 2024-11-14 DOI: 10.1126/science.adu5825
Eugene Gerden
{"title":"Russia postpones three scientific 'megaprojects'.","authors":"Eugene Gerden","doi":"10.1126/science.adu5825","DOIUrl":"https://doi.org/10.1126/science.adu5825","url":null,"abstract":"<p><p>Economic sanctions, budget woes hamper progress on x-ray sources and neutron beams.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"718"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The counterattack. 反击
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-11-15 Epub Date: 2024-11-14 DOI: 10.1126/science.adu5507
Jennifer Couzin-Frankel
{"title":"The counterattack.","authors":"Jennifer Couzin-Frankel","doi":"10.1126/science.adu5507","DOIUrl":"10.1126/science.adu5507","url":null,"abstract":"<p><p>An immune cell treatment that fights cancer is now taking aim at autoimmune disease.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"719-723"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Famed flipping ship gets second shot at research. 著名的翻转船获得了第二次研究机会。
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-11-15 Epub Date: 2024-11-14 DOI: 10.1126/science.adu5823
Sean Cummings
{"title":"Famed flipping ship gets second shot at research.","authors":"Sean Cummings","doi":"10.1126/science.adu5823","DOIUrl":"https://doi.org/10.1126/science.adu5823","url":null,"abstract":"<p><p>Saved from the scrapyard, unique ocean platform to be revamped before redeployment.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"716"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SPL13 controls a root apical meristem phase change by triggering oriented cell divisions SPL13 通过触发定向细胞分裂来控制根尖分生组织的相变
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-11-15 DOI: 10.1126/science.ado4298
Baojun Yang, Yanbiao Sun, Max Minne, Yanhua Ge, Qianru Yue, Vera Goossens, Eliana Mor, Brenda Callebaut, Kevin Bevernaege, Johan M. Winne, Dominique Audenaert, Bert De Rybel
{"title":"SPL13 controls a root apical meristem phase change by triggering oriented cell divisions","authors":"Baojun Yang,&nbsp;Yanbiao Sun,&nbsp;Max Minne,&nbsp;Yanhua Ge,&nbsp;Qianru Yue,&nbsp;Vera Goossens,&nbsp;Eliana Mor,&nbsp;Brenda Callebaut,&nbsp;Kevin Bevernaege,&nbsp;Johan M. Winne,&nbsp;Dominique Audenaert,&nbsp;Bert De Rybel","doi":"10.1126/science.ado4298","DOIUrl":"10.1126/science.ado4298","url":null,"abstract":"<div >Oriented cell divisions are crucial for determining the overall morphology and size of plants, but what controls the onset and duration of this process remains largely unknown. Here, we identified a small molecule that activates root apical meristem (RAM) expression of SQUAMOSA PROMOTER BINDING PROTEIN-LIKE13 (SPL13) a known player in the shoot’s juvenile-to-adult transition. This expression leads to oriented cell divisions in the RAM through SHORT ROOT (SHR) and cell cycle regulators. We further show that the RAM has distinct juvenile and adult phases typed by morphological and molecular characteristics and that SPL factors are crucially required for this transition in <i>Arabidopsis</i> and rice (<i>Oryza sativa</i>). In summary, we provide molecular insights into the age-dependent morphological changes occurring in the RAM during phase change.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":""},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
News at a glance. 新闻一览
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-11-15 Epub Date: 2024-11-14 DOI: 10.1126/science.adu5818
{"title":"News at a glance.","authors":"","doi":"10.1126/science.adu5818","DOIUrl":"https://doi.org/10.1126/science.adu5818","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"710-711"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research advocates see 'no good news for science'. 研究倡导者认为 "科学没有好消息"。
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-11-15 Epub Date: 2024-11-14 DOI: 10.1126/science.adu5820
Jeffrey Mervis
{"title":"Research advocates see 'no good news for science'.","authors":"Jeffrey Mervis","doi":"10.1126/science.adu5820","DOIUrl":"https://doi.org/10.1126/science.adu5820","url":null,"abstract":"<p><p>Trump agenda and a Republican Congress point to funding cuts and policy shifts.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6723","pages":"712-713"},"PeriodicalIF":44.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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