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A dynamic biointerface controls mussel adhesion 动态生物界面控制贻贝粘附。
IF 56.9 1区 综合性期刊
Science Pub Date : 2023-11-16 DOI: 10.1126/science.adl2002
Guoqing Pan, Bin Li
{"title":"A dynamic biointerface controls mussel adhesion","authors":"Guoqing Pan,&nbsp;Bin Li","doi":"10.1126/science.adl2002","DOIUrl":"10.1126/science.adl2002","url":null,"abstract":"<div >Marine mussel adhesion to surfaces has been extensively studied owing to its potential as an adhesive in wet conditions (<i>1-3</i>). However, most studies focus on the chemical binding mechanism of mussel byssus, an adhesive secreta, to surfaces (<i>4</i>), whereas the connections between living tissue and the byssus have rarely been explored. Although strong adherence of mussels on rocky reefs is necessary for survival, these sessile organisms can liberate themselves from anchored substrates to regain mobility when encountering predators or harsh environments (<i>5</i>). How do mussels ensure strong and compact connection to byssus yet quickly release it when needed? On page 829 of this issue, Sivasundarampillai <i>et al.</i> (<i>6</i>) reveal that the dynamic biointerface between mussel tissue and byssus plays an important role in Mytilus mussels. Their finding could be informative about how nonliving materials can be dynamically interfaced with living tissue, as in the case of detachable biosensors and medical implants.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"382 6672","pages":""},"PeriodicalIF":56.9,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Curbing global solid waste emissions toward net-zero warming futures 遏制全球固体废物排放，实现净零变暖的未来。
IF 56.9 1区 综合性期刊
Science Pub Date : 2023-11-16 DOI: 10.1126/science.adg3177
Zheng Xuan Hoy, Kok Sin Woon, Wen Cheong Chin, Yee Van Fan, Seung Jick Yoo
{"title":"Curbing global solid waste emissions toward net-zero warming futures","authors":"Zheng Xuan Hoy,&nbsp;Kok Sin Woon,&nbsp;Wen Cheong Chin,&nbsp;Yee Van Fan,&nbsp;Seung Jick Yoo","doi":"10.1126/science.adg3177","DOIUrl":"10.1126/science.adg3177","url":null,"abstract":"<div >No global analysis has considered the warming that could be averted through improved solid waste management and how much that could contribute to meeting the Paris Agreement’s 1.5° and 2°C pathway goals or the terms of the Global Methane Pledge. With our estimated global solid waste generation of 2.56 to 3.33 billion tonnes by 2050, implementing abrupt technical and behavioral changes could result in a net-zero warming solid waste system relative to 2020, leading to 11 to 27 billion tonnes of carbon dioxide warming–equivalent emissions under the temperature limits. These changes, however, require accelerated adoption within 9 to 17 years (by 2033 to 2041) to align with the Global Methane Pledge. Rapidly reducing methane, carbon dioxide, and nitrous oxide emissions is necessary to maximize the short-term climate benefits and stop the ongoing temperature rise.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"382 6672","pages":""},"PeriodicalIF":56.9,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polio eradication efforts: Above all, do no harm 根除小儿麻痹症的努力:最重要的是，不要造成伤害。
IF 56.9 1区 综合性期刊
Science Pub Date : 2023-11-16 DOI: 10.1126/science.adl2371
Stanley A. Plotkin, Konstantin Chumakov
{"title":"Polio eradication efforts: Above all, do no harm","authors":"Stanley A. Plotkin,&nbsp;Konstantin Chumakov","doi":"10.1126/science.adl2371","DOIUrl":"10.1126/science.adl2371","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"382 6672","pages":""},"PeriodicalIF":56.9,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The responsibility turn 《建模的政治:科学与政策之间的数字》Andrea Saltelli和Monica Di Fiore主编。牛津大学出版社，2023。272页。
IF 56.9 1区 综合性期刊
Science Pub Date : 2023-11-16 DOI: 10.1126/science.adl3473
Ehsan Nabavi, Saman Razavi
{"title":"The responsibility turn","authors":"Ehsan Nabavi,&nbsp;Saman Razavi","doi":"10.1126/science.adl3473","DOIUrl":"10.1126/science.adl3473","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"382 6672","pages":""},"PeriodicalIF":56.9,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Imaging nuclear architecture in single cells 单细胞核结构成像。
IF 56.9 1区 综合性期刊
Science Pub Date : 2023-11-16 DOI: 10.1126/science.adl4460
Yodai Takei
{"title":"Imaging nuclear architecture in single cells","authors":"Yodai Takei","doi":"10.1126/science.adl4460","DOIUrl":"10.1126/science.adl4460","url":null,"abstract":"<div >The smallest functional unit in our bodies, the cell, is spatially organized with various molecules, including DNA, RNA, and proteins. Studying the subcellular organization of molecules in individual cells is fundamental for understanding diverse cell types and states, from neurons to cancer cells. The cell’s nucleus—a highly organized membrane-bound organelle that contains genomic DNA in eukaryotes—is closely linked with complex gene regulation in higher organisms. Revealing its three-dimensional (3D) organization is therefore of considerable interest to a wide range of fields, including developmental biology, neuroscience, and human disease. Great advances have been made, from the groundbreaking observations of the nuclear structures in mammalian neurons under light microscopy by Santiago Ramón y Cajal in 1910 to modern genomics and imaging technologies (<i>1</i>, <i>2</i>). However, technical limitations in the direct measurement of spatial organization of molecules in the nucleus still limit what insights can be gained into 3D nuclear architecture and gene regulation.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"382 6672","pages":""},"PeriodicalIF":56.9,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Working up an appetite to promote repair 激发食欲促进身体修复。
IF 56.9 1区 综合性期刊
Science Pub Date : 2023-11-16 DOI: 10.1126/science.adl4292
Rachel M. Kratofil
{"title":"Working up an appetite to promote repair","authors":"Rachel M. Kratofil","doi":"10.1126/science.adl4292","DOIUrl":"10.1126/science.adl4292","url":null,"abstract":"<div >Neutrophils, monocytes, and macrophages are among the first immune responders to an infectious agent. Although a strong inflammatory response is essential to clear bacteria, the subsequent tissue repair responses that restore homeostasis after infection remain less clear. Neutrophils, which have remarkable phagocytic abilities and antipathogen defenses (<i>1</i>), are recruited en masse from the blood and bone marrow to sites of infection, where they function to capture and kill bacteria. Monocytes are also recruited to infection sites, and it has been presumed that these cells mature into macrophages and aid neutrophils in bacterial clearance. However, the exact functional role of recruited monocytes during bacterial infection was unknown. Monocytes are incredibly plastic and can functionally adapt during inflammation and injury to promote tissue repair (<i>2</i>–<i>4</i>). Although monocytes can phagocytose bacteria, is this their bona fide in vivo function, or can recruited monocytes acquire reparative roles?</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"382 6672","pages":""},"PeriodicalIF":56.9,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emergent symmetry in a low-dimensional superconductor on the edge of Mottness 莫特尼斯边缘低维超导体中的涌现对称性。
IF 56.9 1区 综合性期刊
Science Pub Date : 2023-11-16 DOI: 10.1126/science.abp8948
P. Chudzinski, M. Berben, Xiaofeng Xu, N. Wakeham, B. Bernáth, C. Duffy, R. D. H. Hinlopen, Yu-Te Hsu, S. Wiedmann, P. Tinnemans, Rongying Jin, M. Greenblatt, N. E. Hussey
{"title":"Emergent symmetry in a low-dimensional superconductor on the edge of Mottness","authors":"P. Chudzinski,&nbsp;M. Berben,&nbsp;Xiaofeng Xu,&nbsp;N. Wakeham,&nbsp;B. Bernáth,&nbsp;C. Duffy,&nbsp;R. D. H. Hinlopen,&nbsp;Yu-Te Hsu,&nbsp;S. Wiedmann,&nbsp;P. Tinnemans,&nbsp;Rongying Jin,&nbsp;M. Greenblatt,&nbsp;N. E. Hussey","doi":"10.1126/science.abp8948","DOIUrl":"10.1126/science.abp8948","url":null,"abstract":"<div >Upon cooling, condensed-matter systems typically transition into states of lower symmetry. The converse—i.e., the emergence of higher symmetry at lower temperatures—is extremely rare. In this work, we show how an unusually isotropic magnetoresistance in the highly anisotropic, one-dimensional conductor Li<sub>0.9</sub>Mo<sub>6</sub>O<sub>17</sub> and its temperature dependence can be interpreted as a renormalization group (RG) flow toward a so-called separatrix. This approach is equivalent to an emergent symmetry in the system. The existence of two distinct ground states, Mott insulator and superconductor, can then be traced back to two opposing RG trajectories. By establishing a direct link between quantum field theory and an experimentally measurable quantity, we uncover a path through which emergent symmetry might be identified in other candidate materials.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"382 6672","pages":""},"PeriodicalIF":56.9,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grabbing neuropeptide signals in the brain 捕捉大脑中的神经肽信号。
IF 56.9 1区 综合性期刊
Science Pub Date : 2023-11-16 DOI: 10.1126/science.adl1788
Roman A. Romanov, Tibor Harkany
{"title":"Grabbing neuropeptide signals in the brain","authors":"Roman A. Romanov,&nbsp;Tibor Harkany","doi":"10.1126/science.adl1788","DOIUrl":"10.1126/science.adl1788","url":null,"abstract":"<div >CommunicatIon between neurons in the brain involves the release of either fast (for example, glutamate, γ-aminobutyric acid) or slow neurotransmitters (for example, catecholamines, histamine) from the presynaptic terminal, alone or together with neuromodulators. Fast neurotransmitters induce ion currents in the postsynaptic neuron. By contrast, slow neurotransmitters and neuromodulators act on metabotropic G protein–coupled receptors (GPCRs) in the postsynaptic membrane to trigger intracellular second messenger cascades. Neuropeptides are a superfamily of neuromodulators—more than 100 have been identified . However, studying neuropeptides is challenging owing to the limitations of available tools for their detection. Furthermore, despite decades of drug development aimed at neuropeptide-GPCRs, neither their localization nor the dynamics of ligand-induced activation is sufficiently understood. On page 786 of this issue, Wang <i>et al.</i> (<i>1</i>) describe GPCR-activation–based sensors (GRABs) that can track neuropeptide action in vivo. Such GRABs have the potential to provide new information on physiological processes (<i>2</i>) and the role of GPCRs in brain diseases.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"382 6672","pages":""},"PeriodicalIF":56.9,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Particle-phase accretion forms dimer esters in pinene secondary organic aerosol 颗粒相吸积在蒎烯二级有机气溶胶中形成二聚酯。
IF 56.9 1区 综合性期刊
Science Pub Date : 2023-11-16 DOI: 10.1126/science.adi0857
Christopher M. Kenseth, Nicholas J. Hafeman, Samir P. Rezgui, Jing Chen, Yuanlong Huang, Nathan F. Dalleska, Henrik G. Kjaergaard, Brian M. Stoltz, John H. Seinfeld, Paul O. Wennberg
{"title":"Particle-phase accretion forms dimer esters in pinene secondary organic aerosol","authors":"Christopher M. Kenseth,&nbsp;Nicholas J. Hafeman,&nbsp;Samir P. Rezgui,&nbsp;Jing Chen,&nbsp;Yuanlong Huang,&nbsp;Nathan F. Dalleska,&nbsp;Henrik G. Kjaergaard,&nbsp;Brian M. Stoltz,&nbsp;John H. Seinfeld,&nbsp;Paul O. Wennberg","doi":"10.1126/science.adi0857","DOIUrl":"10.1126/science.adi0857","url":null,"abstract":"<div >Secondary organic aerosol (SOA) is ubiquitous in the atmosphere and plays a pivotal role in climate, air quality, and health. The production of low-volatility dimeric compounds through accretion reactions is a key aspect of SOA formation. However, despite extensive study, the structures and thus the formation mechanisms of dimers in SOA remain largely uncharacterized. In this work, we elucidate the structures of several major dimer esters in SOA from ozonolysis of α-pinene and β-pinene—substantial global SOA sources—through independent synthesis of authentic standards. We show that these dimer esters are formed in the particle phase and propose a mechanism of nucleophilic addition of alcohols to a cyclic acylperoxyhemiacetal. This chemistry likely represents a general pathway to dimeric compounds in ambient SOA.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"382 6672","pages":""},"PeriodicalIF":56.9,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time-resolved live-cell spectroscopy reveals EphA2 multimeric assembly 时间分辨活细胞光谱显示EphA2多聚体组装。
IF 56.9 1区 综合性期刊
Science Pub Date : 2023-11-16 DOI: 10.1126/science.adg5314
Xiaojun Shi, Ryan Lingerak, Cameron J. Herting, Yifan Ge, Soyeon Kim, Paul Toth, Wei Wang, Benjamin P. Brown, Jens Meiler, Khalid Sossey-Alaoui, Matthias Buck, Juha Himanen, Dolores Hambardzumyan, Dimitar B. Nikolov, Adam W. Smith, Bingcheng Wang
{"title":"Time-resolved live-cell spectroscopy reveals EphA2 multimeric assembly","authors":"Xiaojun Shi,&nbsp;Ryan Lingerak,&nbsp;Cameron J. Herting,&nbsp;Yifan Ge,&nbsp;Soyeon Kim,&nbsp;Paul Toth,&nbsp;Wei Wang,&nbsp;Benjamin P. Brown,&nbsp;Jens Meiler,&nbsp;Khalid Sossey-Alaoui,&nbsp;Matthias Buck,&nbsp;Juha Himanen,&nbsp;Dolores Hambardzumyan,&nbsp;Dimitar B. Nikolov,&nbsp;Adam W. Smith,&nbsp;Bingcheng Wang","doi":"10.1126/science.adg5314","DOIUrl":"10.1126/science.adg5314","url":null,"abstract":"<div >Ephrin type-A receptor 2 (EphA2) is a receptor tyrosine kinase that initiates both ligand-dependent tumor-suppressive and ligand-independent oncogenic signaling. We used time-resolved, live-cell fluorescence spectroscopy to show that the ligand-free EphA2 assembles into multimers driven by two types of intermolecular interactions in the ectodomain. The first type entails extended symmetric interactions required for ligand-induced receptor clustering and tumor-suppressive signaling that inhibits activity of the oncogenic extracellular signal–regulated kinase (ERK) and protein kinase B (AKT) protein kinases and suppresses cell migration. The second type is an asymmetric interaction between the amino terminus and the membrane proximal domain of the neighboring receptors, which supports oncogenic signaling and promotes migration in vitro and tumor invasiveness in vivo. Our results identify the molecular interactions that drive the formation of the EphA2 multimeric signaling clusters and reveal the pivotal role of EphA2 assembly in dictating its opposing functions in oncogenesis.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"382 6674","pages":""},"PeriodicalIF":56.9,"publicationDate":"2023-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136399053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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