Norepinephrine signals through astrocytes to modulate synapses.

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-05-15 DOI:10.1126/science.adq5480

Katheryn B Lefton, Yifan Wu, Yanchao Dai, Takao Okuda, Yufen Zhang, Allen Yen, Gareth M Rurak, Sarah Walsh, Rachel Manno, Bat-Erdene Myagmar, Joseph D Dougherty, Vijay K Samineni, Paul C Simpson, Thomas Papouin

引用次数: 0

Abstract

Locus ceruleus (LC)-derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level mechanisms are elusive. Here, we show that NE remodeling of synaptic function is completely independent from its binding on neuronal receptors. Instead, astrocytic adrenergic receptors and calcium dynamics fully gate the effect of NE on synapses. Additionally, we found that NE suppression of synaptic strength results from an adenosine 5'-triphosphate (ATP)-derived and A1 adenosine receptor-mediated control of presynaptic efficacy. These findings suggest that astrocytes are a core component of neuromodulatory systems and the circuit effector through which NE produces network and behavioral adaptations.

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去甲肾上腺素信号通过星形胶质细胞调节突触。

蓝斑（LC）衍生的去甲肾上腺素（NE）通过重新配置回路功能连接来驱动网络和行为适应环境，但潜在的突触水平机制尚不清楚。在这里，我们发现突触功能的NE重塑完全独立于其与神经元受体的结合。相反，星形细胞肾上腺素能受体和钙动力学完全限制了NE对突触的影响。此外，我们发现NE对突触强度的抑制源于5'-三磷酸腺苷（ATP）衍生和A1腺苷受体介导的突触前功效控制。这些发现表明，星形胶质细胞是神经调节系统的核心组成部分，也是神经网络产生网络和行为适应的电路效应器。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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