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Active-reset protein sensors enable continuous in vivo monitoring of inflammation.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-06 Epub Date: 2024-12-05 DOI: 10.1126/science.adn2600
H Zargartalebi, S Mirzaie, A GhavamiNejad, S U Ahmed, F Esmaeili, A Geraili, C D Flynn, D Chang, J Das, A Abdrabou, E H Sargent, S O Kelley
{"title":"Active-reset protein sensors enable continuous in vivo monitoring of inflammation.","authors":"H Zargartalebi, S Mirzaie, A GhavamiNejad, S U Ahmed, F Esmaeili, A Geraili, C D Flynn, D Chang, J Das, A Abdrabou, E H Sargent, S O Kelley","doi":"10.1126/science.adn2600","DOIUrl":"10.1126/science.adn2600","url":null,"abstract":"<p><p>Continuous measurement of proteins in vivo is important for real-time disease management and prevention. Implantable sensors for monitoring small molecules such as glucose have been available for more than a decade. However, analysis of proteins remains an unmet need because the lower physiological levels require that sensors have high affinities, which are linked to long complexation half-lives (<i>t</i><sub>1/2</sub> ~20 hours) and slow equilibration when concentrations decrease. We report active-reset sensors by use of high-frequency oscillations to accelerate dissociation, which enables regeneration of the unbound form of the sensor within 1 minute. When implemented within implanted devices, these sensors allow for real-time, in vivo monitoring of proteins within interstitial fluid. Active-reset protein sensors track biomarker levels on a physiological timescale for inflammation monitoring in living animals.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6726","pages":"1146-1153"},"PeriodicalIF":44.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous monitoring with a shake.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-06 Epub Date: 2024-12-05 DOI: 10.1126/science.adt8928
Sihong Wang
{"title":"Continuous monitoring with a shake.","authors":"Sihong Wang","doi":"10.1126/science.adt8928","DOIUrl":"10.1126/science.adt8928","url":null,"abstract":"<p><p>Oscillating signals rapidly reset a sensor for real-time protein detection in the body.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6726","pages":"1093-1094"},"PeriodicalIF":44.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Speaking for myself.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-06 Epub Date: 2024-12-05 DOI: 10.1126/science.adu9386
Ogochukwu Joseph Uweru
{"title":"Speaking for myself.","authors":"Ogochukwu Joseph Uweru","doi":"10.1126/science.adu9386","DOIUrl":"https://doi.org/10.1126/science.adu9386","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6726","pages":"1182"},"PeriodicalIF":44.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How the brain hatches an escape.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-06 Epub Date: 2024-12-05 DOI: 10.1126/science.adu0649
Francesco Argenton, Yoav Gothilf
{"title":"How the brain hatches an escape.","authors":"Francesco Argenton, Yoav Gothilf","doi":"10.1126/science.adu0649","DOIUrl":"10.1126/science.adu0649","url":null,"abstract":"<p><p>A neuroendocrine circuit controls when fish larvae are ready to hatch.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6726","pages":"1090-1091"},"PeriodicalIF":44.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A conserved bacterial genetic basis for commensal-host specificity.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-06 Epub Date: 2024-12-05 DOI: 10.1126/science.adp7748
Karina Gutiérrez-García, Kevin Aumiller, Ren Dodge, Benjamin Obadia, Ann Deng, Sneha Agrawal, Xincheng Yuan, Richard Wolff, Haolong Zhu, Ru-Ching Hsia, Nandita Garud, William B Ludington
{"title":"A conserved bacterial genetic basis for commensal-host specificity.","authors":"Karina Gutiérrez-García, Kevin Aumiller, Ren Dodge, Benjamin Obadia, Ann Deng, Sneha Agrawal, Xincheng Yuan, Richard Wolff, Haolong Zhu, Ru-Ching Hsia, Nandita Garud, William B Ludington","doi":"10.1126/science.adp7748","DOIUrl":"10.1126/science.adp7748","url":null,"abstract":"<p><p>Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are bacterial cell surface proteins that facilitate attachment to host tissues and are often virulence factors for opportunistic pathogens. However, the attachments are often transient and nonspecific, and additional mechanisms are required to sustain infection. In this work, we use live imaging of individual symbiotic bacterial cells colonizing the gut of living <i>Drosophila melanogaster</i> to show that <i>Lactiplantibacillus plantarum</i> specifically recognizes the fruit fly foregut as a distinct physical niche. <i>L. plantarum</i> establishes stably within its niche through host-specific adhesins encoded by genes carried on a colonization island. The adhesin binding domains are conserved throughout the Lactobacillales, and the island also encodes a secretion system widely conserved among commensal and pathogenic bacteria.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6726","pages":"1117-1122"},"PeriodicalIF":44.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-06 Epub Date: 2024-12-05 DOI: 10.1126/science.adt0180
Ting-Hui Lin, Xueyong Zhu, Shengyang Wang, Ding Zhang, Ryan McBride, Wenli Yu, Simeon Babarinde, James C Paulson, Ian A Wilson
{"title":"A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors.","authors":"Ting-Hui Lin, Xueyong Zhu, Shengyang Wang, Ding Zhang, Ryan McBride, Wenli Yu, Simeon Babarinde, James C Paulson, Ian A Wilson","doi":"10.1126/science.adt0180","DOIUrl":"10.1126/science.adt0180","url":null,"abstract":"<p><p>In 2024, several human infections with highly pathogenic clade 2.3.4.4b bovine influenza H5N1 viruses in the United States raised concerns about their capability for bovine-to-human or even human-to-human transmission. In this study, analysis of the hemagglutinin (HA) from the first-reported human-infecting bovine H5N1 virus (A/Texas/37/2024, Texas) revealed avian-type receptor binding preference. Notably, a Gln<sup>226</sup>Leu substitution switched Texas HA binding specificity to human-type receptors, which was enhanced when combined with an Asn<sup>224</sup>Lys mutation. Crystal structures of the Texas HA with avian receptor analog LSTa and its Gln<sup>226</sup>Leu mutant with human receptor analog LSTc elucidated the structural basis for this preferential receptor recognition. These findings highlight the need for continuous surveillance of emerging mutations in avian and bovine clade 2.3.4.4b H5N1 viruses.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6726","pages":"1128-1134"},"PeriodicalIF":44.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controversial study redraws classical picture of the neuron.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-06 Epub Date: 2024-12-05 DOI: 10.1126/science.adv0709
Sofia Quaglia
{"title":"Controversial study redraws classical picture of the neuron.","authors":"Sofia Quaglia","doi":"10.1126/science.adv0709","DOIUrl":"10.1126/science.adv0709","url":null,"abstract":"<p><p>Fine-grained imaging of mouse brain cells suggests \"pearling\" of axons that may help with signaling.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6726","pages":"1084-1085"},"PeriodicalIF":44.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
News at a glance.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-06 Epub Date: 2024-12-05 DOI: 10.1126/science.adv0703
{"title":"News at a glance.","authors":"","doi":"10.1126/science.adv0703","DOIUrl":"https://doi.org/10.1126/science.adv0703","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6726","pages":"1078-1079"},"PeriodicalIF":44.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Products.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-06 Epub Date: 2024-12-05 DOI: 10.1126/science.adu9387
{"title":"New Products.","authors":"","doi":"10.1126/science.adu9387","DOIUrl":"https://doi.org/10.1126/science.adu9387","url":null,"abstract":"<p><p>A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6726","pages":"1179"},"PeriodicalIF":44.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic gene circuits drive disease-fighting T cells.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-06 Epub Date: 2024-12-05 DOI: 10.1126/science.adt9921
Marco L Davila, Renier Brentjens
{"title":"Synthetic gene circuits drive disease-fighting T cells.","authors":"Marco L Davila, Renier Brentjens","doi":"10.1126/science.adt9921","DOIUrl":"10.1126/science.adt9921","url":null,"abstract":"<p><p>Immune cells can be programmed to deliver targeted therapies in models of brain and inflammatory disease.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6726","pages":"1094-1095"},"PeriodicalIF":44.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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