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Funding delays frustrate agricultural researchers. 资金延迟让农业研究人员感到沮丧。
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-18 DOI: 10.1126/science.aec3555
Erik Stokstad
{"title":"Funding delays frustrate agricultural researchers.","authors":"Erik Stokstad","doi":"10.1126/science.aec3555","DOIUrl":"https://doi.org/10.1126/science.aec3555","url":null,"abstract":"<p><p>Grants awarded by the U.S. Department of Agriculture have dropped sharply.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6766","pages":"1173-1174"},"PeriodicalIF":45.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protect academia in Sudan with global action 用全球行动保护苏丹的学术界。
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-18 DOI: 10.1126/science.aea1930
Hisham Y. Hassan
{"title":"Protect academia in Sudan with global action","authors":"Hisham Y. Hassan","doi":"10.1126/science.aea1930","DOIUrl":"10.1126/science.aea1930","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6766","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quantum squeezing of a levitated nanomechanical oscillator 悬浮纳米机械振荡器的量子压缩
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-18 DOI: 10.1126/science.ady4652
Mitsuyoshi Kamba, Naoki Hara, Kiyotaka Aikawa
{"title":"Quantum squeezing of a levitated nanomechanical oscillator","authors":"Mitsuyoshi Kamba,&nbsp;Naoki Hara,&nbsp;Kiyotaka Aikawa","doi":"10.1126/science.ady4652","DOIUrl":"10.1126/science.ady4652","url":null,"abstract":"<div >Manipulating the motion of macroscopic objects near their quantum mechanical uncertainties has been desired in diverse fields, including fundamental physics, sensing, and transducers. Despite progress in ground-state cooling of a levitated solid particle, realizing its nonclassical states has been elusive. Here, we demonstrate quantum squeezing of the motion of a single nanoparticle by rapidly varying its oscillation frequency. We reveal appreciable narrowing of the velocity variance to –4.9 ± 0.1 decibels of that of the ground state using free-expansion measurements. Our work shows that a levitated nanoparticle offers an ideal platform for studying nonclassical states of its motion and provides a route to developing applications in quantum sensing and exploring quantum mechanics at a macroscopic scale.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6766","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinetic organization of the genome revealed by ultraresolution multiscale live imaging 超分辨率多尺度实时成像揭示的基因组动力学组织
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-18 DOI: 10.1126/science.adx2202
Joo Lee, Liang-Fu Chen, Simon Gaudin, Kavvya Gupta, Ana Novacic, Andrew Spakowitz, Alistair Nicol Boettiger
{"title":"Kinetic organization of the genome revealed by ultraresolution multiscale live imaging","authors":"Joo Lee,&nbsp;Liang-Fu Chen,&nbsp;Simon Gaudin,&nbsp;Kavvya Gupta,&nbsp;Ana Novacic,&nbsp;Andrew Spakowitz,&nbsp;Alistair Nicol Boettiger","doi":"10.1126/science.adx2202","DOIUrl":"10.1126/science.adx2202","url":null,"abstract":"<div >Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian chromosomes with self-mapping fluorescent labels and track them at ultraresolution. We find that sequences separated by submegabase distances transition to proximity in tens of seconds. This rapid search is dependent on cohesin and is exhibited only within domains. Domain borders act as kinetic impediments to this search process, rather than structural boundaries. The genomic separation–dependent scaling of the search time for cis interactions violated predictions of diffusion, suggesting motor-driven folding. We also uncover cohesin-dependent processive motion at 2.7 kilobases per second. Together, these multiscale dynamics reveal the organization of the genome into kinetically associated domains.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6766","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Other Journals 在其他期刊。
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-18 DOI: 10.1126/science.aec3211
Sacha Vignieri, Priscilla N. Kelly, Michael A. Funk, Sarah H. Ross, Stella M. Hurtley, Sumin Jin, Jake S. Yeston
{"title":"In Other Journals","authors":"Sacha Vignieri,&nbsp;Priscilla N. Kelly,&nbsp;Michael A. Funk,&nbsp;Sarah H. Ross,&nbsp;Stella M. Hurtley,&nbsp;Sumin Jin,&nbsp;Jake S. Yeston","doi":"10.1126/science.aec3211","DOIUrl":"10.1126/science.aec3211","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6766","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.aec3211","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wastewater surveillance requires ethical use 废水监测需要合乎道德的使用。
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-18 DOI: 10.1126/science.adq6656
Patrick M. D’Aoust
{"title":"Wastewater surveillance requires ethical use","authors":"Patrick M. D’Aoust","doi":"10.1126/science.adq6656","DOIUrl":"10.1126/science.adq6656","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6766","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145086985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A shot at survival. 一次生存的机会。
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-18 DOI: 10.1126/science.aec3214
Leslie Roberts
{"title":"A shot at survival.","authors":"Leslie Roberts","doi":"10.1126/science.aec3214","DOIUrl":"https://doi.org/10.1126/science.aec3214","url":null,"abstract":"<p><p>Fifty years ago, Carol Baker proposed vaccinating pregnant women to save babies from a deadly microbe. Now, the idea is nearing fruition.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6766","pages":"1175-1179"},"PeriodicalIF":45.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145087000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic demography predicts community dynamics in a temperate montane forest 基因组人口统计学预测温带山地森林的群落动态。
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-18 DOI: 10.1126/science.adu6396
James P. O’Dwyer, James A. Lutz, Tyler Schappe, Dana Alegre, Andrew N. Black, Niklaus J. Grünwald, F. Andrew Jones
{"title":"Genomic demography predicts community dynamics in a temperate montane forest","authors":"James P. O’Dwyer,&nbsp;James A. Lutz,&nbsp;Tyler Schappe,&nbsp;Dana Alegre,&nbsp;Andrew N. Black,&nbsp;Niklaus J. Grünwald,&nbsp;F. Andrew Jones","doi":"10.1126/science.adu6396","DOIUrl":"10.1126/science.adu6396","url":null,"abstract":"<div >Species population sizes fluctuate over time, and these temporal dynamics play a key role in governing the maintenance of biodiversity. Although modeling approaches have been developed to characterize fluctuations in species abundances, the data required to parameterize these models from scratch are substantial. Here we introduce a new approach to modeling population fluctuations on decadal timescales by relating community-level dynamics to population-level patterns encoded in plant genomes. Using genomic samples taken at a single time point to generate contemporary effective population size estimates in a temperate montane forest, we accurately predict fluctuations across three censuses. Our approach facilitates the use of genomic demography to parameterize multispecies community models in ecology and shows that population genomic data can provide accurate predictions for ecological dynamics.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6766","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beware the drive to scale technology 要小心对规模化技术的追求。
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-18 DOI: 10.1126/science.aeb3069
Shobita Parthasarathy
{"title":"Beware the drive to scale technology","authors":"Shobita Parthasarathy","doi":"10.1126/science.aeb3069","DOIUrl":"10.1126/science.aeb3069","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6766","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene 一个基因组位点的功能图谱揭示了增强子受其靶基因的限制
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-18 DOI: 10.1126/science.ads6552
Mathias Eder, Christina J. I. Moene, Lise Dauban, Mikhail Magnitov, Jamie Drayton, Marcel de Haas, Christ Leemans, Martijn Verkuilen, Elzo de Wit, Anders S. Hansen, Bas van Steensel
{"title":"Functional maps of a genomic locus reveal confinement of an enhancer by its target gene","authors":"Mathias Eder,&nbsp;Christina J. I. Moene,&nbsp;Lise Dauban,&nbsp;Mikhail Magnitov,&nbsp;Jamie Drayton,&nbsp;Marcel de Haas,&nbsp;Christ Leemans,&nbsp;Martijn Verkuilen,&nbsp;Elzo de Wit,&nbsp;Anders S. Hansen,&nbsp;Bas van Steensel","doi":"10.1126/science.ads6552","DOIUrl":"10.1126/science.ads6552","url":null,"abstract":"<div >Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alternative positions within a single locus, we dissected the positional relationship between the mouse <i>Sox2</i> gene and its distal enhancer. This revealed an intricate, sharply confined activation landscape in which the native <i>Sox2</i> gene occupies an optimal position for its activation. Deletion of the gene relaxes this confinement and broadly increases reporter activity. The confining effect of the <i>Sox2</i> gene is partially conferred by its ~1-kilobase coding region. Our local relocation approach provides high-resolution functional maps of a genomic locus and reveals that a gene can strongly constrain the realm of influence of its enhancer.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6766","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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