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Why democracies die and what to do next 为什么民主会消亡，接下来该怎么做
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.aea4600
Rachel Beatty Riedl
{"title":"Why democracies die and what to do next","authors":"Rachel Beatty Riedl","doi":"10.1126/science.aea4600","DOIUrl":"10.1126/science.aea4600","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Science's grim mood colors lighthearted Ig Nobel prizes. 科学的严峻气氛为轻松的搞笑诺贝尔奖增添了色彩。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.aec5466
Hannah Richter
{"title":"Science's grim mood colors lighthearted Ig Nobel prizes.","authors":"Hannah Richter","doi":"10.1126/science.aec5466","DOIUrl":"https://doi.org/10.1126/science.aec5466","url":null,"abstract":"Some winning researchers decline to attend celebration, citing politics and visa restrictions.","PeriodicalId":21678,"journal":{"name":"Science","volume":"64 1","pages":"1279-1280"},"PeriodicalIF":56.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of short-range ordering motifs in semiconductors 半导体中短程有序基序的识别
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.adu0719
Lilian M. Vogl, Shunda Chen, Peter Schweizer, Xiaochen Jin, Shui-Qing Yu, Jifeng Liu, Tianshu Li, Andrew M. Minor
{"title":"Identification of short-range ordering motifs in semiconductors","authors":"Lilian M. Vogl,&nbsp;Shunda Chen,&nbsp;Peter Schweizer,&nbsp;Xiaochen Jin,&nbsp;Shui-Qing Yu,&nbsp;Jifeng Liu,&nbsp;Tianshu Li,&nbsp;Andrew M. Minor","doi":"10.1126/science.adu0719","DOIUrl":"10.1126/science.adu0719","url":null,"abstract":"<div >Chemical short-range ordering is expected to be a key factor for tuning the electronic structure of semiconductors. However, experimental evidence of short-range ordering is still lacking due to the challenge of characterizing atomic-scale ordering motifs. Here, we determined the presence of short-range order in a ternary GeSiSn semiconductor system using advanced energy-filtered four-dimensional scanning transmission electron microscopy and large-scale atomistic models generated by a machine learning neuroevolution potential of first-principles accuracy. This approach revealed preferred ordering of different atomic species with the dominant occurrence of Si–Ge–Sn triplets. Our findings not only confirmed the presence of short-range order but also directly revealed the actual atomic structure, demonstrating the potential for informed atomic order–based band engineering as a third degree of freedom beyond composition and strain tuning.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From reactive to proactive: Continuous protein monitoring for preventive health care 从被动到主动：预防保健的连续蛋白质监测
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.ady6497
Jane M. Donnelly, Ryan A. Neff, Andrew J. H. Sedlack, Vuslat B. Juska, Luis Fernando Ayala-Cardona, Joseph Bass, Elizabeth M. McNally, Sanjiv J. Shah, Nabil Alshurafa, Eyal Y. Kimchi, G. R. Scott Budinger, Shana O. Kelley
{"title":"From reactive to proactive: Continuous protein monitoring for preventive health care","authors":"Jane M. Donnelly,&nbsp;Ryan A. Neff,&nbsp;Andrew J. H. Sedlack,&nbsp;Vuslat B. Juska,&nbsp;Luis Fernando Ayala-Cardona,&nbsp;Joseph Bass,&nbsp;Elizabeth M. McNally,&nbsp;Sanjiv J. Shah,&nbsp;Nabil Alshurafa,&nbsp;Eyal Y. Kimchi,&nbsp;G. R. Scott Budinger,&nbsp;Shana O. Kelley","doi":"10.1126/science.ady6497","DOIUrl":"10.1126/science.ady6497","url":null,"abstract":"<div >Continuous biomarker monitoring is revolutionizing chronic disease management, with glucose monitoring for diabetes as the primary example. Given the success of this approach, a transition to continuous protein monitoring (CPM, a real-time, implantable or wearable technology) could similarly advance precision medicine. In this work, we review state-of-the-art CPM platforms and their prospective clinical impact across both chronic disorders—metabolic, cardiovascular, autoimmune, and neurodegenerative—and acute crises, such as sepsis and transplant dysfunction. We also highlight remaining barriers to widespread adoption, including sensor stability, robust machine learning models for live interpretation, and responsible data handling for patient privacy. With continued engineering and clinical validation, emerging biosensor technologies could transform disease management, facilitating earlier interventions and individualizing treatment strategies, ultimately improving patient outcomes.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual transposon sequencing profiles the genetic interaction landscape in bacteria 双转座子测序描述了细菌的遗传相互作用景观
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.adt7685
Justin J. Zik, Morgan N. Price, Keisha Hanifa Alma Mayra, Audrey A. Santoso, Adam P. Arkin, Adam M. Deutschbauer, Lok-To Sham
{"title":"Dual transposon sequencing profiles the genetic interaction landscape in bacteria","authors":"Justin J. Zik,&nbsp;Morgan N. Price,&nbsp;Keisha Hanifa Alma Mayra,&nbsp;Audrey A. Santoso,&nbsp;Adam P. Arkin,&nbsp;Adam M. Deutschbauer,&nbsp;Lok-To Sham","doi":"10.1126/science.adt7685","DOIUrl":"10.1126/science.adt7685","url":null,"abstract":"<div >Gene redundancy complicates systematic characterization of gene function as single-gene deletions may not produce discernible phenotypes. We report dual transposon sequencing (dual Tn-seq), a platform for assaying the fitness of a comprehensive double mutant pool in parallel. Dual Tn-seq couples random barcode transposon site sequencing with the Cre-<i>lox</i> system, enabling deep sampling of 73% of the 1.3 million possible double gene deletions in <i>Streptococcus pneumoniae</i>. The genetic interactions identified span a wide range of biochemical processes, revealing new factors in presumably well-studied pathways, exemplified by a cytidine triphosphate synthase PyrJ. Moreover, this approach should permit further investigation of growth condition–specific genetic interactions. Because dual Tn-seq does not require the construction of a large array of single mutants, it should be readily adaptable to various microorganisms.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity 脱氮酰化是IV型CBASS免疫所需的核碱基-蛋白偶联
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.adx6053
Douglas R. Wassarman, Patrick Pfaff, Joao A. Paulo, Steven P. Gygi, Kevan M. Shokat, Philip J. Kranzusch
{"title":"Deazaguanylation is a nucleobase-protein conjugation required for type IV CBASS immunity","authors":"Douglas R. Wassarman,&nbsp;Patrick Pfaff,&nbsp;Joao A. Paulo,&nbsp;Steven P. Gygi,&nbsp;Kevan M. Shokat,&nbsp;Philip J. Kranzusch","doi":"10.1126/science.adx6053","DOIUrl":"10.1126/science.adx6053","url":null,"abstract":"<div >7-Deazapurines are nucleobase analogs essential for nucleic acid modifications in nearly all cellular life. In this study, we discovered a role for 7-deazapurines in protein modification within type IV cyclic oligonucleotide–based antiviral signaling system (CBASS) antiphage defense and defined functions for CBASS ancillary proteins Cap9 and Cap10 in nucleobase-protein conjugation. A structure of Cap10 revealed a transfer RNA transglycosylase family enzyme remodeled to bind a partner cGAS/DncV–like nucleotidyltransferase that is modified with an N-terminal 7-amido-7-deazaguanine (NDG) nucleobase. A structure of Cap9 explained how this QueC-like enzyme co-opts a 7-deazapurine biosynthetic reaction to install NDG. We show that Cap9, Cap10, and protein deazaguanylation are essential for host defense against phage infection. Our results define a 7-deazapurine protein modification and explain how nucleobase biosynthetic machinery has been repurposed for antiviral immunity.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Other Journals 在其他期刊
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.aec5109
Bianca Lopez, Sarah Lemprière, Angela Hessler, Caroline Ash, Priscilla N. Kelly, Marc S. Lavine, Yury Suleymanov
{"title":"In Other Journals","authors":"Bianca Lopez,&nbsp;Sarah Lemprière,&nbsp;Angela Hessler,&nbsp;Caroline Ash,&nbsp;Priscilla N. Kelly,&nbsp;Marc S. Lavine,&nbsp;Yury Suleymanov","doi":"10.1126/science.aec5109","DOIUrl":"10.1126/science.aec5109","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.aec5109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tourism puts Zanzibari reserve at a crossroads 旅游业将桑给巴尔保护区置于十字路口
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.aeb5285
Tim Caro, Giacomo Baldesi, Grazia Borrini-Feyerabend, Matthew Clark, Viola Clausnitzer, Klaas-Douwe B. Dijkstra, Andy Dobson, Raffael Ernst, Olivier Hamerlynck, Quentin Luke, Simone Orsenigo, Ilaria Pretelli, Juan Rita, Melita Vamberger
{"title":"Tourism puts Zanzibari reserve at a crossroads","authors":"Tim Caro,&nbsp;Giacomo Baldesi,&nbsp;Grazia Borrini-Feyerabend,&nbsp;Matthew Clark,&nbsp;Viola Clausnitzer,&nbsp;Klaas-Douwe B. Dijkstra,&nbsp;Andy Dobson,&nbsp;Raffael Ernst,&nbsp;Olivier Hamerlynck,&nbsp;Quentin Luke,&nbsp;Simone Orsenigo,&nbsp;Ilaria Pretelli,&nbsp;Juan Rita,&nbsp;Melita Vamberger","doi":"10.1126/science.aeb5285","DOIUrl":"10.1126/science.aeb5285","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Researchers customize AI tools at global 'hackathon'. 研究人员在全球“黑客马拉松”上定制人工智能工具。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.aec5465
Zack Savitsky
{"title":"Researchers customize AI tools at global 'hackathon'.","authors":"Zack Savitsky","doi":"10.1126/science.aec5465","DOIUrl":"https://doi.org/10.1126/science.aec5465","url":null,"abstract":"Large language models are tweaked and tuned to accelerate research in materials science and chemistry.","PeriodicalId":21678,"journal":{"name":"Science","volume":"41 1","pages":"1278-1279"},"PeriodicalIF":56.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hanford set to finally lock up nuclear waste in glass. 汉福德准备最终将核废料封存在玻璃中。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-09-18 DOI: 10.1126/science.aec3551
Warren Cornwall
{"title":"Hanford set to finally lock up nuclear waste in glass.","authors":"Warren Cornwall","doi":"10.1126/science.aec3551","DOIUrl":"https://doi.org/10.1126/science.aec3551","url":null,"abstract":"But some officials fear Trump administration may be aiming for an alternative solution.","PeriodicalId":21678,"journal":{"name":"Science","volume":"68 1","pages":"1166-1167"},"PeriodicalIF":56.9,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145083461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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