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Corporate tourism threatens protected areas 企业旅游威胁着保护区
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.aeb0953
Christopher J. O’Bryan, James R. Allan, Meitamei Ole Dapash
{"title":"Corporate tourism threatens protected areas","authors":"Christopher J. O’Bryan, James R. Allan, Meitamei Ole Dapash","doi":"10.1126/science.aeb0953","DOIUrl":"10.1126/science.aeb0953","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Buried salt is abetting Arctic thaw. 埋在地下的盐正在加速北极的融化。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.aec5463
Tim Appenzeller
{"title":"Buried salt is abetting Arctic thaw.","authors":"Tim Appenzeller","doi":"10.1126/science.aec5463","DOIUrl":"https://doi.org/10.1126/science.aec5463","url":null,"abstract":"Ancient layers of saline permafrost are melting below zero, deepening lakes and weakening coasts.","PeriodicalId":21678,"journal":{"name":"Science","volume":"86 1","pages":"1276-1277"},"PeriodicalIF":56.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full utilization of noble metals by atom abstraction for propane dehydrogenation. 用原子萃取法充分利用贵金属进行丙烷脱氢。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.adw3053
Guodong Sun,Ran Luo,Donglong Fu,Kexin Wu,Xianhui Wang,Xiaoqing Bian,Zhenpu Lu,Xin Chang,Zhi Wang,Siwei Huang,Yihan Zhu,Jihan Zhou,Sai Chen,Chunlei Pei,Zhi-Jian Zhao,Jinlong Gong
{"title":"Full utilization of noble metals by atom abstraction for propane dehydrogenation.","authors":"Guodong Sun,Ran Luo,Donglong Fu,Kexin Wu,Xianhui Wang,Xiaoqing Bian,Zhenpu Lu,Xin Chang,Zhi Wang,Siwei Huang,Yihan Zhu,Jihan Zhou,Sai Chen,Chunlei Pei,Zhi-Jian Zhao,Jinlong Gong","doi":"10.1126/science.adw3053","DOIUrl":"https://doi.org/10.1126/science.adw3053","url":null,"abstract":"Maximizing atomic utilization of noble metals is crucial for efficient industrial catalysis. We demonstrate that minimal platinum (Pt) loading for propane dehydrogenation (PDH) can be achieved through atom abstraction. At low loadings of Pt with copper (Cu), reduction over silica or other oxide supports formed nanoparticles (NPs) with Pt mainly dispersed in the bulk. Addition of tin (Sn) to the alloy led to formation of surface Pt1Sn1 dimers. The larger atomic radius of Sn compared to Cu drove it to the surface, and its stronger interactions with Pt abstracted it from the bulk. Single metallic Pt atoms were stabilized on fully open surfaces, resulting in nearly 100% surface exposure. This configuration reduced Pt usage by one order of magnitude for propane dehydrogenation and improved catalytic stability.","PeriodicalId":21678,"journal":{"name":"Science","volume":"42 1","pages":"eadw3053"},"PeriodicalIF":56.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction 收缩
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.aec1773
Phan Tan Toi, Hyun Jae Jang, Kyeongseon Min, Sung-Phil Kim, Seung-Kyun Lee, Jongho Lee, Jeehyun Kwag, Jang-Yeon Park
{"title":"Retraction","authors":"Phan Tan Toi, Hyun Jae Jang, Kyeongseon Min, Sung-Phil Kim, Seung-Kyun Lee, Jongho Lee, Jeehyun Kwag, Jang-Yeon Park","doi":"10.1126/science.aec1773","DOIUrl":"10.1126/science.aec1773","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.aec1773","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Op-eds connect scientists and communities 专栏将科学家和社区联系起来
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.aea8713
Miles J. Arnett
{"title":"Op-eds connect scientists and communities","authors":"Miles J. Arnett","doi":"10.1126/science.aea8713","DOIUrl":"10.1126/science.aea8713","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysosomes signal through the epigenome to regulate longevity across generations 溶酶体通过表观基因组发出信号来调节代际寿命
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.adn8754
Qinghao Zhang, Weiwei Dang, Meng C. Wang
{"title":"Lysosomes signal through the epigenome to regulate longevity across generations","authors":"Qinghao Zhang,&nbsp;Weiwei Dang,&nbsp;Meng C. Wang","doi":"10.1126/science.adn8754","DOIUrl":"10.1126/science.adn8754","url":null,"abstract":"<div >The epigenome is sensitive to metabolic inputs and is crucial for aging. Lysosomes act as a signaling hub to sense metabolic cues and regulate longevity. We found that lysosomal metabolic pathways signal through the epigenome to regulate transgenerational longevity in <i>Caenorhabditis elegans</i>. Activation of lysosomal lipid signaling and lysosomal adenosine monophosphate–activated protein kinase (AMPK) or reduction of lysosomal mechanistic target of rapamycin (mTOR) signaling increased the expression of a histone H3.3 variant and increased its methylation on K79, leading to life-span extension across multiple generations. This transgenerational prolongevity effect required intestine-to-germline transportation of histone H3.3 and a germline-specific H3K79 methyltransferase and was recapitulated by overexpressing H3.3 or the H3K79 methyltransferase. Thus, signals from a lysosome affect the epigenome and link the soma and germ line to mediate transgenerational inheritance of longevity.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic U2AF cycling defines two phases of cotranscriptional pre-mRNA splicing 动态U2AF循环定义了共转录pre-mRNA剪接的两个阶段
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.adj9141
Changwei Shao, Yajing Hao, Li Jiang, Dong Wang, Rui Wang, Yuanjun Li, Hui Wang, Yaping Ge, Rui Bai, Xiangjuan Du, Xizi Chen, Tan Wu, Lan-Tao Gou, Ruixue Wan, Yanhui Xu, Xiong Ji, Xiang-Dong Fu
{"title":"Dynamic U2AF cycling defines two phases of cotranscriptional pre-mRNA splicing","authors":"Changwei Shao,&nbsp;Yajing Hao,&nbsp;Li Jiang,&nbsp;Dong Wang,&nbsp;Rui Wang,&nbsp;Yuanjun Li,&nbsp;Hui Wang,&nbsp;Yaping Ge,&nbsp;Rui Bai,&nbsp;Xiangjuan Du,&nbsp;Xizi Chen,&nbsp;Tan Wu,&nbsp;Lan-Tao Gou,&nbsp;Ruixue Wan,&nbsp;Yanhui Xu,&nbsp;Xiong Ji,&nbsp;Xiang-Dong Fu","doi":"10.1126/science.adj9141","DOIUrl":"10.1126/science.adj9141","url":null,"abstract":"<div >Distinguishing functional splice sites from abundant cryptic sites in precursor messenger RNAs (pre-mRNAs) represents a fundamental challenge in decoding mammalian genomes. We demonstrate that the specific RNA polymerase II (Pol II) subunit RPB9 directly interacts with the 3′ AG dinucleotide binding factor U2AF1 to initiate 3′ splice site recognition. Combined with recent structural insights into Pol II–mediated 5′ splice site selection, these findings support a cotranscriptional mechanism to recognize paired 3′ and 5′ splice sites across individual exons. These initial exon definition events facilitate the recruitment of U2AF2 to heterodimerize with U2AF1, which also triggers U2AF1 release from elongating Pol II. Collectively, these results reveal dynamic U2AF cycling that partitions Pol II subunit–facilitated splice site recognition and subsequent Pol II–independent spliceosome assembly steps during cotranscriptional splicing.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness 机械敏感基因组增强子增强细胞对基质刚度的反应
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.adl1988
Brian D. Cosgrove, Lexi R. Bounds, Carson Key Taylor, Alan L. Su, Anthony J. Rizzo, Alejandro Barrera, Tongyu Sun, Alexias Safi, Lingyun Song, Thomas Whitlow, Aleksandra Tata, Nahid Iglesias, Yarui Diao, Purushothama Rao Tata, Brenton D. Hoffman, Gregory E. Crawford, Charles A. Gersbach
{"title":"Mechanosensitive genomic enhancers potentiate the cellular response to matrix stiffness","authors":"Brian D. Cosgrove, Lexi R. Bounds, Carson Key Taylor, Alan L. Su, Anthony J. Rizzo, Alejandro Barrera, Tongyu Sun, Alexias Safi, Lingyun Song, Thomas Whitlow, Aleksandra Tata, Nahid Iglesias, Yarui Diao, Purushothama Rao Tata, Brenton D. Hoffman, Gregory E. Crawford, Charles A. Gersbach","doi":"10.1126/science.adl1988","DOIUrl":"https://doi.org/10.1126/science.adl1988","url":null,"abstract":"Epigenetic control of gene expression and cellular phenotype is influenced by changes in the local microenvironment, yet how mechanical cues precisely influence epigenetic state to regulate transcription remains largely unmapped. Here, we combine genome-wide epigenome profiling, epigenome editing, and phenotypic and single-cell RNA-seq CRISPR screening to identify a class of genomic enhancers that responds to the mechanical microenvironment. These “mechanoenhancers” can be preferentially activated on either soft or stiff extracellular matrix contexts and regulate transcription to influence critical cell functions including apoptosis, adhesion, proliferation, and migration. Epigenetic editing of mechanoenhancers reprograms the cellular response to the mechanical microenvironment and modulates the activation of disease-related genes in lung fibroblasts from healthy and fibrotic donors. Epigenetic editing of mechanoenhancers holds potential for precise targeting of mechanically-driven diseases.","PeriodicalId":21678,"journal":{"name":"Science","volume":"88 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance 前和后抗生素时代：抗菌素耐药性的历史传播
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.adr1522
Adrian Cazares, Wendy Figueroa, Daniel Cazares, Leandro Lima, Jake D. Turnbull, Hannah McGregor, Jo Dicks, Sarah Alexander, Zamin Iqbal, Nicholas R. Thomson
{"title":"Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance","authors":"Adrian Cazares, Wendy Figueroa, Daniel Cazares, Leandro Lima, Jake D. Turnbull, Hannah McGregor, Jo Dicks, Sarah Alexander, Zamin Iqbal, Nicholas R. Thomson","doi":"10.1126/science.adr1522","DOIUrl":"https://doi.org/10.1126/science.adr1522","url":null,"abstract":"Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predating the antibiotic era (PAE). By investigating plasmids from clinically relevant bacteria sampled and isolated between 1917 and 1954 and comparing them to modern plasmids, we have captured over 100 years of evolution. We show that while virtually all PAE plasmids were devoid of resistance genes and most never acquired them, a minority evolved to drive the global spread of resistance to first line and last resort antibiotics in Gram-negative bacteria. Modern plasmids have evolved through complex microevolution and fusion events into a distinct group of highly recombinogenic, multi-replicon, self-transmissible plasmids that now pose the highest risk to resistance dissemination, and therefore to human health.","PeriodicalId":21678,"journal":{"name":"Science","volume":"18 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The vitality of old age 老年的活力
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-09-25 DOI: 10.1126/science.adz7694
Michael A. Goldman
{"title":"The vitality of old age","authors":"Michael A. Goldman","doi":"10.1126/science.adz7694","DOIUrl":"10.1126/science.adz7694","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6767","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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