Diverse bat organoids provide pathophysiological models for zoonotic viruses.

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-05-15 DOI:10.1126/science.adt1438

Hyunjoon Kim, Seo-Young Heo, Young-Il Kim, Dongbin Park, Suhee Hwang, Yong-Ki Lee, Hobin Jang, Jae-Woo Ahn, Jeongmin Ha, Sujin Park, Ho Young Ji, Semi Kim, Isaac Choi, Woohyun Kwon, Jaemoo Kim, Kanghee Kim, Juryeon Gil, Boyeong Jeong, Josea Carmel D Lazarte, Rare Rollon, Jeong Ho Choi, Eun Ha Kim, Seung-Gyu Jang, Hye Kwon Kim, Bo-Young Jeon, Ghazi Kayali, Richard J Webby, Bon-Kyoung Koo, Young Ki Choi

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引用次数: 0

Abstract

Bats are important reservoirs of zoonotic pathogens, but suitable model systems for comprehensively exploring host-pathogen interactions and assessing spillover risks remain limited. To address this gap, we developed a collection of bat organoid models spanning five species and four organ types. This multispecies, multiorgan organoid panel showed species- and tissue-specific replication patterns for several viruses, offering robust pathophysiological models for studying respiratory, renal, and enteric zoonotic viruses. Using this platform, we successfully isolated and characterized bat-borne mammalian orthoreoviruses and paramyxoviruses, demonstrating the utility of these organoid panels for virome surveillance. Furthermore, we successfully tested known antiviral drugs for their efficacy against bat virus isolates.

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多种蝙蝠类器官为人畜共患病毒提供了病理生理模型。

蝙蝠是人畜共患病原体的重要宿主，但用于全面探索宿主-病原体相互作用和评估溢出风险的合适模型系统仍然有限。为了解决这一差距，我们开发了一系列蝙蝠类器官模型，涵盖5个物种和4种器官类型。这个多物种、多器官类器官小组显示了几种病毒的物种和组织特异性复制模式，为研究呼吸道、肾脏和肠道人畜共患病毒提供了强大的病理生理模型。利用该平台，我们成功分离并鉴定了蝙蝠传播的哺乳动物正肠病毒和副粘病毒，证明了这些类器官面板在病毒监测中的实用性。此外，我们成功地测试了已知的抗病毒药物对蝙蝠病毒分离株的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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