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Caught in the crosshairs 被瞄准了
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-07-31 DOI: 10.1126/science.aeb0043
Richard Stone
{"title":"Caught in the crosshairs","authors":"Richard Stone","doi":"10.1126/science.aeb0043","DOIUrl":"10.1126/science.aeb0043","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6759","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.aeb0043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frontline science. 前沿科学。
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-07-31 DOI: 10.1126/science.aeb0042
Richard Stone
{"title":"Frontline science.","authors":"Richard Stone","doi":"10.1126/science.aeb0042","DOIUrl":"https://doi.org/10.1126/science.aeb0042","url":null,"abstract":"<p><p>As Ukraine's war with Russia grinds on, the nation's civilian scientists are playing a growing role in military R&D.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6759","pages":"446-451"},"PeriodicalIF":45.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Escherichia coli with a 57-codon genetic code 有57个密码子的大肠杆菌
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-07-31 DOI: 10.1126/science.ady4368
Wesley E. Robertson, Fabian B. H. Rehm, Martin Spinck, Raffael L. Schumann, Rongzhen Tian, Wei Liu, Yangqi Gu, Askar A. Kleefeldt, Cicely F. Day, Kim C. Liu, Yonka Christova, Jérôme F. Zürcher, Franz L. Böge, Jakob Birnbaum, Linda van Bijsterveldt, Jason W. Chin
{"title":"Escherichia coli with a 57-codon genetic code","authors":"Wesley E. Robertson, Fabian B. H. Rehm, Martin Spinck, Raffael L. Schumann, Rongzhen Tian, Wei Liu, Yangqi Gu, Askar A. Kleefeldt, Cicely F. Day, Kim C. Liu, Yonka Christova, Jérôme F. Zürcher, Franz L. Böge, Jakob Birnbaum, Linda van Bijsterveldt, Jason W. Chin","doi":"10.1126/science.ady4368","DOIUrl":"https://doi.org/10.1126/science.ady4368","url":null,"abstract":"The near-universal genetic code uses 64 codons to encode the 20 canonical amino acids and protein synthesis. Here we designed and generated <jats:italic toggle=\"yes\">Escherichia coli</jats:italic> with a 4 Mb synthetic genome in which we replaced known occurrences of six sense codons and a stop codon with synonymous codons. The resulting organism, Syn57, uses 55 codons to encode the 20 canonical amino acids.","PeriodicalId":21678,"journal":{"name":"Science","volume":"16 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Science Journals 在科学期刊上
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-07-31 DOI: 10.1126/science.aeb0036
Jesse Smith, Jelena Stajic, Mattia Maroso, Ian S. Osborne, Sacha Vignieri, Bianca Lopez, Seth Thomas Scanlon, John Foley, Priscilla N. Kelly, Stella M. Hurtley, L. Bryan Ray, Phil Szuromi, Jake S. Yeston, Stephanie M. Willerth, Courtney Malo
{"title":"In Science Journals","authors":"Jesse Smith,&nbsp;Jelena Stajic,&nbsp;Mattia Maroso,&nbsp;Ian S. Osborne,&nbsp;Sacha Vignieri,&nbsp;Bianca Lopez,&nbsp;Seth Thomas Scanlon,&nbsp;John Foley,&nbsp;Priscilla N. Kelly,&nbsp;Stella M. Hurtley,&nbsp;L. Bryan Ray,&nbsp;Phil Szuromi,&nbsp;Jake S. Yeston,&nbsp;Stephanie M. Willerth,&nbsp;Courtney Malo","doi":"10.1126/science.aeb0036","DOIUrl":"10.1126/science.aeb0036","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6759","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.aeb0036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beavers advance into the high Arctic. 海狸向北极高地挺进。
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-07-31 DOI: 10.1126/science.aeb0430
Warren Cornwall
{"title":"Beavers advance into the high Arctic.","authors":"Warren Cornwall","doi":"10.1126/science.aeb0430","DOIUrl":"https://doi.org/10.1126/science.aeb0430","url":null,"abstract":"<p><p>Dams and ponds will transform landscapes in northern Alaska.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6759","pages":"443-444"},"PeriodicalIF":45.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome study a 'quantum leap' in explaining stuttering. 基因组研究是解释口吃的“量子飞跃”。
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-07-31 DOI: 10.1126/science.aeb0428
Nazeefa Ahmed
{"title":"Genome study a 'quantum leap' in explaining stuttering.","authors":"Nazeefa Ahmed","doi":"10.1126/science.aeb0428","DOIUrl":"https://doi.org/10.1126/science.aeb0428","url":null,"abstract":"<p><p>Analysis of 23andMe user data points to variants in genes linked to brain function and sense of rhythm.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6759","pages":"440-441"},"PeriodicalIF":45.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144761209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diversity-oriented photobiocatalytic synthesis via stereoselective three-component radical coupling 立体选择性三组分自由基偶联的多样性导向光生物催化合成
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-07-31 DOI: 10.1126/science.adx2935
Chen Zhang, Jun Zhou, Pei-Pei Xie, Silvia M. Rivera, Turki M. Alturaifi, James Finnigan, Simon Charnock, Peng Liu, Yang Yang
{"title":"Diversity-oriented photobiocatalytic synthesis via stereoselective three-component radical coupling","authors":"Chen Zhang, Jun Zhou, Pei-Pei Xie, Silvia M. Rivera, Turki M. Alturaifi, James Finnigan, Simon Charnock, Peng Liu, Yang Yang","doi":"10.1126/science.adx2935","DOIUrl":"https://doi.org/10.1126/science.adx2935","url":null,"abstract":"Enzymatic multicomponent C–C bond forming reactions for diversity-oriented synthesis remain rare. Using cooperative photobiocatalysis, we developed a stereoselective three-component radical-mediated C–C coupling unknown in both organic chemistry and biochemistry. Directed evolution of repurposed pyridoxal decarboxylases enabled full fragment variability in this three-component coupling, giving rise to six classes of valuable products, many of which were inaccessible by other methods, even in a racemic fashion. This enzymatic platform integrates a range of asymmetric catalysis principles, including remote stereocenter construction, stereodivergent catalysis, kinetic resolution and parallel kinetic resolution, achieving excellent diastereo- and enantiocontrol over radical intermediates. The broad substrate scope and complementary specificities of evolved enzyme variants enabled combinatorial library synthesis, affording structurally and stereochemically diverse scaffolds for medicinal chemistry.","PeriodicalId":21678,"journal":{"name":"Science","volume":"19 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Experiencing the Arctic 体验北极
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-07-31 DOI: 10.1126/science.ady6388
Jaime Herndon
{"title":"Experiencing the Arctic","authors":"Jaime Herndon","doi":"10.1126/science.ady6388","DOIUrl":"10.1126/science.ady6388","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6759","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting the brain after spinal cord injury: Targeted deep brain stimulation improves walking after injury 脊髓损伤后靶向脑：靶向脑深部刺激改善损伤后行走
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-07-31 DOI: 10.1126/science.aea0845
Newton Cho
{"title":"Targeting the brain after spinal cord injury: Targeted deep brain stimulation improves walking after injury","authors":"Newton Cho","doi":"10.1126/science.aea0845","DOIUrl":"10.1126/science.aea0845","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6759","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.aea0845","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dust-driven droplet freezing explains cloud-top phase in the northern extratropics 尘埃驱动的液滴冻结解释了北部温带地区的云顶阶段
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-07-31 DOI: 10.1126/science.adt5354
D. Villanueva, M. Stengel, C. Hoose, O. Bruno, K. Jeggle, A. Ansmann, U. Lohmann
{"title":"Dust-driven droplet freezing explains cloud-top phase in the northern extratropics","authors":"D. Villanueva,&nbsp;M. Stengel,&nbsp;C. Hoose,&nbsp;O. Bruno,&nbsp;K. Jeggle,&nbsp;A. Ansmann,&nbsp;U. Lohmann","doi":"10.1126/science.adt5354","DOIUrl":"10.1126/science.adt5354","url":null,"abstract":"<div >Clouds between −39° and 0°C can be topped by a liquid or ice layer, which affects their radiative forcing and precipitation. The cloud-top ice-to-total frequency (ITF) quantifies the occurrence of clouds with an ice top relative to total cloud occurrence, but the factors controlling ITF are poorly understood. Using 35 years of satellite data, we show that in the Northern Hemisphere, between −15° and −30°C, dust aerosol is strongly correlated with ITF in both time and space. Furthermore, we found that the sensitivities of ITF to temperature and dust are in a ratio that agrees with laboratory measurements of droplet freezing, showing that ITF can be attributed to dust aerosol.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6759","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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