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Pharma's hot zone. 制药行业的热点。
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aec7036
Robert F Service
{"title":"Pharma's hot zone.","authors":"Robert F Service","doi":"10.1126/science.aec7036","DOIUrl":"https://doi.org/10.1126/science.aec7036","url":null,"abstract":"<p><p>A new generation of radiotherapies promises a more targeted attack on cancer.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":"17-21"},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A computer scientist’s technological gamble 计算机科学家的技术赌博
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aeb1091
Jonathan Wai
{"title":"A computer scientist’s technological gamble","authors":"Jonathan Wai","doi":"10.1126/science.aeb1091","DOIUrl":"10.1126/science.aeb1091","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wildfire management at a crossroads: Mitigation and prevention or response and recovery? 十字路口的野火管理：缓解和预防还是响应和恢复？
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.adx1230
Robert Gray, Robin Gregory, Calvin Sandborn
{"title":"Wildfire management at a crossroads: Mitigation and prevention or response and recovery?","authors":"Robert Gray,&nbsp;Robin Gregory,&nbsp;Calvin Sandborn","doi":"10.1126/science.adx1230","DOIUrl":"10.1126/science.adx1230","url":null,"abstract":"<div >Catastrophic wildfires—those that kill and injure people, destroy homes and communities, cause widespread evacuations, and cost large sums of money to suppress—are on the rise around the world. With global warming, it is likely that such impacts will continue to increase in scope, frequency, and magnitude (<i>1</i>). We examine the case of the Canadian province of British Columbia (BC) as a good example of a government at a crossroads: Does it begin to invest heavily in proactive large-scale efforts to mitigate the effects of current and future wildfires (i.e., preventive landscape-scale treatments), or does it continue to primarily react with fire suppression and postburn recovery measures? Although we focus on BC, this same tough question, along with lessons learned and our main recommendations, apply to regional and national governments in dozens of countries.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upwelling that lasted millions of years 上升流持续了数百万年
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aeb4832
Yair Rosenthal, Anya V. Hess
{"title":"Upwelling that lasted millions of years","authors":"Yair Rosenthal,&nbsp;Anya V. Hess","doi":"10.1126/science.aeb4832","DOIUrl":"10.1126/science.aeb4832","url":null,"abstract":"<div >The eastern equatorial Pacific along the coast of the Americas extending from Mexico to Peru is one of the most biologically productive regions of the world’s oceans. In this geographical zone, dissolved nutrients and carbon dioxide gas in deep water move upward to the surface (upwelling), where the gas can escape to the atmosphere. Consequently, this region exerts a major influence on atmospheric carbon dioxide concentration. Many efforts have been made to predict the behavior of this region under future climate conditions (<i>1</i>) by reconstructing ocean behavior in the Pliocene epoch (5.3 million to 2.6 million years ago) as a potential analog (<i>2</i>). On page 45 of this issue, Rafter <i>et al.</i> (<i>3</i>) report that modern-like upwelling in the eastern equatorial Pacific has persisted over 5 million years, which is contradictory to existing paradigms. This suggests a potentially lesser impact of future global warming on upwelling than previously thought.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The paradox of AI accelerationism and the promise of public interest AI 人工智能加速主义的悖论与公共利益人工智能的承诺
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aeb5789
Chinasa T. Okolo
{"title":"The paradox of AI accelerationism and the promise of public interest AI","authors":"Chinasa T. Okolo","doi":"10.1126/science.aeb5789","DOIUrl":"10.1126/science.aeb5789","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asynchronous subunit transitions prime acetylcholine receptor activation 异步亚基跃迁起始乙酰胆碱受体激活
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.adw1264
Mackenzie J. Thompson, Christian J. G. Tessier, Anna Ananchenko, Camille Hénault, Johnathon R. Emlaw, François Dehez, Eleftherios Zarkadas, Corrie J. B. daCosta, Hugues Nury, John E. Baenziger
{"title":"Asynchronous subunit transitions prime acetylcholine receptor activation","authors":"Mackenzie J. Thompson, Christian J. G. Tessier, Anna Ananchenko, Camille Hénault, Johnathon R. Emlaw, François Dehez, Eleftherios Zarkadas, Corrie J. B. daCosta, Hugues Nury, John E. Baenziger","doi":"10.1126/science.adw1264","DOIUrl":"https://doi.org/10.1126/science.adw1264","url":null,"abstract":"Communication at synapses is facilitated by postsynaptic receptors, which convert a chemical signal into an electrical response. For ligand-gated ion channels, agonist binding triggers rapid transitions through intermediate states leading to a transient open-pore conformation, with these transitions shaping the post-synaptic response. Here, we determine structures of the muscle-type nicotinic acetylcholine receptor in unliganded, mono-liganded, and di-liganded states. Agonist binding to a single site stabilizes a closed structure where an entire principal agonist-binding subunit transitions to an active-like conformation, while the other unoccupied principal subunit remains inactive, albeit poised for activation. Uniting this intermediate structure with single-channel recordings informs a sequential activation mechanism where asynchronous subunit transitions prime the receptor for activation, a finding with implications for an entire superfamily of pentameric ligand-gated ion channels.","PeriodicalId":21678,"journal":{"name":"Science","volume":"36 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lithium-ion intercalation by coupled ion-electron transfer 离子-电子耦合转移的锂离子嵌入
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.adq2541
Yirui Zhang, Dimitrios Fraggedakis, Tao Gao, Shakul Pathak, Debbie Zhuang, Cristina Grosu, Yash Samantaray, Armando R. C. Neto, Sravani R. Duggirala, Botao Huang, Yun Guang Zhu, Livia Giordano, Ryoichi Tatara, Harsh Agarwal, Ryan M. Stephens, Martin Z. Bazant, Yang Shao-Horn
{"title":"Lithium-ion intercalation by coupled ion-electron transfer","authors":"Yirui Zhang,&nbsp;Dimitrios Fraggedakis,&nbsp;Tao Gao,&nbsp;Shakul Pathak,&nbsp;Debbie Zhuang,&nbsp;Cristina Grosu,&nbsp;Yash Samantaray,&nbsp;Armando R. C. Neto,&nbsp;Sravani R. Duggirala,&nbsp;Botao Huang,&nbsp;Yun Guang Zhu,&nbsp;Livia Giordano,&nbsp;Ryoichi Tatara,&nbsp;Harsh Agarwal,&nbsp;Ryan M. Stephens,&nbsp;Martin Z. Bazant,&nbsp;Yang Shao-Horn","doi":"10.1126/science.adq2541","DOIUrl":"10.1126/science.adq2541","url":null,"abstract":"<div >The underlying reaction mechanism in lithium-ion batteries remains poorly understood. We provide experimental and theoretical evidence that lithium intercalation occurs by coupled ion-electron transfer, where ion transfer across the electrode-electrolyte interface is facilitated by electron transfer to a neighboring redox site. Electrochemical measurements for a variety of common electrode and electrolyte materials reveal a universal dependence of the (de-)intercalation rate on Li<sup>+</sup> vacancy fraction, as well as temperature and electrolyte effects consistent with the theory, which could be used to guide the molecular design of lithium-ion battery interfaces.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two-dimensional diboron trioxide crystal composed by boroxol groups 由硼砂基组成的二维三氧化二硼晶体
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.adv2582
T. Zio, M. Dirindin, C. Di Giorgio, M. Thaler, B. Achatz, C. Cepek, I Cojocariu, M. Jugovac, T. O. Menteş, A. Locatelli, L. L. Patera, A. Sala, G. Comelli, M. Peressi, C. Africh
{"title":"Two-dimensional diboron trioxide crystal composed by boroxol groups","authors":"T. Zio,&nbsp;M. Dirindin,&nbsp;C. Di Giorgio,&nbsp;M. Thaler,&nbsp;B. Achatz,&nbsp;C. Cepek,&nbsp;I Cojocariu,&nbsp;M. Jugovac,&nbsp;T. O. Menteş,&nbsp;A. Locatelli,&nbsp;L. L. Patera,&nbsp;A. Sala,&nbsp;G. Comelli,&nbsp;M. Peressi,&nbsp;C. Africh","doi":"10.1126/science.adv2582","DOIUrl":"10.1126/science.adv2582","url":null,"abstract":"<div >Diboron trioxide (B<sub>2</sub>O<sub>3</sub>) represents an unusual case among polymorphic oxides, because its vitrified state features superstructural units—planar boroxol groups—that are never observed in its three-dimensional crystalline polymorphs. Crystalline polymorphs that incorporate boroxol groups have only been predicted theoretically, although their formation is crucial to rationalize the ability of B<sub>2</sub>O<sub>3</sub> to vitrify. Here we present the synthesis of a two-dimensional crystalline B<sub>2</sub>O<sub>3</sub> polymorph constituted by boroxol groups arranged in an atomically thin honeycomb lattice. By combining surface science experimental techniques with ab initio calculations, we characterize the structural and electronic properties of this B<sub>2</sub>O<sub>3</sub> polymorph down to the atomic level. This discovery enlarges the family of two-dimensional materials and enables the atomic tracking of individual structural units in trioxides.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
National assessments in verse 国家诗文评估
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aec2579
Rida Ismail, Ana Brenda Guzovsky, Giovana Rosa Gameiro, Camila Fonseca Amorim da Silva, Wadim Strielkowski, Shaimaa Fathy Khalifa, Lucas Matthias Weissenborn, Encieh Erfani, Rasha Hamama, Abdulkader Alhussein, Christian Abagat, Jazreen Angel Plaza, Mariana Rodríguez Donoso, Yuankai Du, Esmeralda Valdivieso-Mora, Ankita Gupta, Eric Demoncheaux, Fotis Tsiroukis, Anas Shawah''en, Oscar Xavier Guerrero Gutiérrez, JiaHao Shi, Casimiro Gerarduzzi, Jawad Ullah, Hao Zhang, Prayan Pokharel, Moram Saeed, Ranjeet Singh Mahla, Rachel Pollard
{"title":"National assessments in verse","authors":"Rida Ismail,&nbsp;Ana Brenda Guzovsky,&nbsp;Giovana Rosa Gameiro,&nbsp;Camila Fonseca Amorim da Silva,&nbsp;Wadim Strielkowski,&nbsp;Shaimaa Fathy Khalifa,&nbsp;Lucas Matthias Weissenborn,&nbsp;Encieh Erfani,&nbsp;Rasha Hamama,&nbsp;Abdulkader Alhussein,&nbsp;Christian Abagat,&nbsp;Jazreen Angel Plaza,&nbsp;Mariana Rodríguez Donoso,&nbsp;Yuankai Du,&nbsp;Esmeralda Valdivieso-Mora,&nbsp;Ankita Gupta,&nbsp;Eric Demoncheaux,&nbsp;Fotis Tsiroukis,&nbsp;Anas Shawah''en,&nbsp;Oscar Xavier Guerrero Gutiérrez,&nbsp;JiaHao Shi,&nbsp;Casimiro Gerarduzzi,&nbsp;Jawad Ullah,&nbsp;Hao Zhang,&nbsp;Prayan Pokharel,&nbsp;Moram Saeed,&nbsp;Ranjeet Singh Mahla,&nbsp;Rachel Pollard","doi":"10.1126/science.aec2579","DOIUrl":"10.1126/science.aec2579","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.aec2579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Canada's Supreme Court will decide fate of ostrich flock hit by bird flu. 加拿大最高法院将决定感染禽流感的鸵鸟群的命运。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aec7426
Jon Cohen
{"title":"Canada's Supreme Court will decide fate of ostrich flock hit by bird flu.","authors":"Jon Cohen","doi":"10.1126/science.aec7426","DOIUrl":"https://doi.org/10.1126/science.aec7426","url":null,"abstract":"Farmers and supporters-including RFK Jr. and Dr. Oz-urge government to spare birds, citing research potential.","PeriodicalId":21678,"journal":{"name":"Science","volume":"75 1","pages":"10-11"},"PeriodicalIF":56.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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