IF 45.8 1区综合性期刊

Science Pub Date : 2025-10-23 DOI: 10.1126/science.adx3741

Anja Ulrich, Kamal Brahim, Andries Boelen, Michiel Debaets, Ahmed Khalil, Conglin Sun, Yishu Huang, Sandeep Seema Saseendran, Marina Baryshnikova, Paola Favia, Thomas Nuytten, Stefanie Sergeant, Kasper Van Gasse, Bart Kuyken, Kristiaan De Greve, Clement Merckling, Christian Haffner

{"title":"Engineering high Pockels coefficients in thin-film strontium titanate for cryogenic quantum electro-optic applications","authors":"Anja Ulrich, Kamal Brahim, Andries Boelen, Michiel Debaets, Ahmed Khalil, Conglin Sun, Yishu Huang, Sandeep Seema Saseendran, Marina Baryshnikova, Paola Favia, Thomas Nuytten, Stefanie Sergeant, Kasper Van Gasse, Bart Kuyken, Kristiaan De Greve, Clement Merckling, Christian Haffner","doi":"10.1126/science.adx3741","DOIUrl":"10.1126/science.adx3741","url":null,"abstract":"<div >Pockels materials are notable for their strong electro-optic interaction and rapid response times and are therefore used extensively in optical communications. However, at cryogenic temperatures, Pockels coefficients are reduced in many materials optimized for room-temperature operation, which is a major hurdle for emerging quantum technologies. Here, we show that strontium titanate (SrTiO<sub>3</sub>) can be engineered to exhibit a Pockels coefficient of 345 picometers per volt at 20 hertz at cryogenic temperatures, a value twice as high as any other thin-film electro-optic material. By adjusting the stoichiometry, we were able to increase the Curie temperature and realize a ferroelectric phase yielding a high Pockels coefficient, so far with limited optical losses of decibels per centimeter. Our findings position SrTiO<sub>3</sub> as a promising material for cryogenic quantum photonics applications.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6771","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantum critical electro-optic and piezo-electric nonlinearities 量子临界电光和压电非线性

IF 45.8 1区综合性期刊

Science Pub Date : 2025-10-23 DOI: 10.1126/science.adx8657

Christopher P. Anderson, Giovanni Scuri, Aaron Chan, Sungjun Eun, Alexander D. White, Geun Ho Ahn, Christine Jilly, Amir Safavi-Naeini, Kasper Van Gasse, Lu Li, Jelena Vučković

引用次数: 0

Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes 线虫端粒酶RNA搭便车在种系上调基因的内含子上

IF 45.8 1区综合性期刊

Science Pub Date : 2025-10-23 DOI: 10.1126/science.ads7778

Yutaka Takeda, Masahiro Onoguchi, Fumiya Ito, Io Yamamoto, Shunsuke Sumi, Tatsuyuki Yoshii, Morié Ishida, Eriko Kajikawa, Jingjing Zhang, Osamu Nishimura, Mitsutaka Kadota, Shunsuke Tagami, Takefumi Kondo, Hirohide Saito, Michiaki Hamada, Hiroki Shibuya

{"title":"Nematode telomerase RNA hitchhikes on introns of germline–up-regulated genes","authors":"Yutaka Takeda, Masahiro Onoguchi, Fumiya Ito, Io Yamamoto, Shunsuke Sumi, Tatsuyuki Yoshii, Morié Ishida, Eriko Kajikawa, Jingjing Zhang, Osamu Nishimura, Mitsutaka Kadota, Shunsuke Tagami, Takefumi Kondo, Hirohide Saito, Michiaki Hamada, Hiroki Shibuya","doi":"10.1126/science.ads7778","DOIUrl":"10.1126/science.ads7778","url":null,"abstract":"<div >Telomerase is a ribonucleoprotein complex that elongates telomeric DNA, ensuring germline immortality. In this study, we identified the <i>Caenorhabditis elegans</i> telomerase RNA component 1 (<i>terc-1</i>), as the first known telomerase RNA expressed as an intronic long noncoding RNA (lncRNA), embedded in an intron of germline–up-regulated gene <i>nmy-2</i>. <i>terc-1</i> undergoes splicing, polyadenylation, and nuclear RNA exosome–dependent maturation, stabilized by H/ACA small nucleolar ribonucleoproteins, thus co-opting the H/ACA small nucleolar RNA (snoRNA) biogenesis machinery. Mutations in <i>terc-1</i> led to progressive telomere shortening and sterility in successive generations. Artificially transplanting the <i>nmy-2</i> intron into the introns of germline-expressed genes but not non–germline-expressed genes restored germline immortality, highlighting the importance of genomic context. Our findings suggest that nematode telomerase RNA is a snoRNA-like intronic lncRNA that exploits the introns of germline–up-regulated genes to ensure species survival.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6771","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Other Journals 在其他期刊

IF 45.8 1区综合性期刊

Science Pub Date : 2025-10-23 DOI: 10.1126/science.aed2502

Sarah Lemprière, Caroline Ash, Sumin Jin, Joana Osório, Bianca Lopez, Yury Suleymanov, Angela Hessler

引用次数: 0

Cybersecurity mandate alarms University of California faculty. 网络安全法规令加州大学教员感到担忧。

IF 56.9 1区综合性期刊

Science Pub Date : 2025-10-23 DOI: 10.1126/science.aed2822

Celina Zhao

引用次数: 0

New study fuels debate over lifesaving antibiotic strategy for children in Africa. 一项新的研究引发了对非洲儿童救命抗生素策略的争论。

IF 56.9 1区综合性期刊

Science Pub Date : 2025-10-23 DOI: 10.1126/science.aed2821

Gretchen Vogel

引用次数: 0

Late-surviving New Mexican dinosaurs illuminate high end-Cretaceous diversity and provinciality 晚期存活的新墨西哥恐龙说明了白垩纪末期的高度多样性和地方性

IF 45.8 1区综合性期刊

Science Pub Date : 2025-10-23 DOI: 10.1126/science.adw3282

Andrew G. Flynn, Stephen L. Brusatte, Alfio Alessandro Chiarenza, Jorge García-Girón, Adam J. Davis, C. Will Fenley IV, Caitlin E. Leslie, Ross Secord, Sarah Shelley, Anne Weil, Matthew T. Heizler, Thomas E. Williamson, Daniel J. Peppe

{"title":"Late-surviving New Mexican dinosaurs illuminate high end-Cretaceous diversity and provinciality","authors":"Andrew G. Flynn, Stephen L. Brusatte, Alfio Alessandro Chiarenza, Jorge García-Girón, Adam J. Davis, C. Will Fenley IV, Caitlin E. Leslie, Ross Secord, Sarah Shelley, Anne Weil, Matthew T. Heizler, Thomas E. Williamson, Daniel J. Peppe","doi":"10.1126/science.adw3282","DOIUrl":"10.1126/science.adw3282","url":null,"abstract":"<div >It has long been debated whether non-avian dinosaurs went extinct abruptly or gradually at the end-Cretaceous (66 million years ago), because their fossil record at this time is mostly limited to northern North America. We constrain a dinosaur-rich unit to the south, the Naashoibito Member in New Mexico, to the very latest Cretaceous (~66.4 to 66.0 million years), preserving some of the last-known non-avian dinosaurs. Ecological modeling shows that North American terrestrial vertebrates maintained high diversity and endemism in the latest Cretaceous and early Paleogene, with bioprovinces shaped by temperature and geography. This counters the notion of a low-diversity cross-continental fauna and suggests that dinosaurs were diverse and partitioned into regionally distinct assemblages during the final few hundred thousand years before the end-Cretaceous asteroid impact.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6771","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.adw3282","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive affective contagion in bumble bees 大黄蜂的积极情感传染

IF 45.8 1区综合性期刊

Science Pub Date : 2025-10-23 DOI: 10.1126/science.adr0216

José E. Romero-González, Zhenwei Zhuo, Lulu Chen, Chaoyang Peng, Cwyn Solvi, Fei Peng

引用次数: 0

Correcting the record on race and medicine 纠正种族和医学方面的记录

IF 45.8 1区综合性期刊

Science Pub Date : 2025-10-23 DOI: 10.1126/science.aea8984

Darrell J. Gaskin

引用次数: 0

The paradox of kin avoidance in parasitic plants 寄生植物的亲缘回避悖论