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In Science Journals 在科学期刊上
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Bianca Lopez, Wei Wong, Phil Szuromi, Ian S. Osborne, Jelena Stajic, Di Jiang, Kip V. Hodges, Orla Smith, Stella M. Hurtley, Michael A. Funk, Caroline Ash, Mattia Maroso, Marc S. Lavine, Claire Olingy
{"title":"In Science Journals","authors":"Bianca Lopez, Wei Wong, Phil Szuromi, Ian S. Osborne, Jelena Stajic, Di Jiang, Kip V. Hodges, Orla Smith, Stella M. Hurtley, Michael A. Funk, Caroline Ash, Mattia Maroso, Marc S. Lavine, Claire Olingy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.ady6156","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis 间期细胞形态决定有丝分裂的方式、对称性和结果
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Holly E. Lovegrove, Georgia E. Hulmes, Sabrina Ghadaouia, Christopher Revell, Marta Giralt-Pujol, Zain Alhashem, Andreia Pena, Damian D. Nogare, Ellen Appleton, Guilherme Costa, Richard L. Mort, Christoph Ballestrem, Gareth W. Jones, Cerys S. Manning, Ajay B. Chitnis, Claudio A. Franco, Claudia Linker, Katie Bentley, Shane P. Herbert
{"title":"Interphase cell morphology defines the mode, symmetry, and outcome of mitosis","authors":"Holly E. Lovegrove,&nbsp;Georgia E. Hulmes,&nbsp;Sabrina Ghadaouia,&nbsp;Christopher Revell,&nbsp;Marta Giralt-Pujol,&nbsp;Zain Alhashem,&nbsp;Andreia Pena,&nbsp;Damian D. Nogare,&nbsp;Ellen Appleton,&nbsp;Guilherme Costa,&nbsp;Richard L. Mort,&nbsp;Christoph Ballestrem,&nbsp;Gareth W. Jones,&nbsp;Cerys S. Manning,&nbsp;Ajay B. Chitnis,&nbsp;Claudio A. Franco,&nbsp;Claudia Linker,&nbsp;Katie Bentley,&nbsp;Shane P. Herbert","doi":"","DOIUrl":"","url":null,"abstract":"<div >During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could concomitantly act as conserved instructive cues that trigger asymmetric division and direct core identity decisions underpinning tissue building. We performed single-cell morphometric analyses of endothelial and other mesenchymal-like cells. Distinct morphological changes switched cells to an “isomorphic” mode of division, which preserved pre-mitotic morphology throughout mitosis. In isomorphic divisions, interphase morphology appeared to provide a geometric code defining mitotic symmetry, fate determinant partitioning, and daughter state. Rab4-positive endosomes recognized this code, allowing them to respond to pre-mitotic morphology and segregate determinants accordingly. Thus, morphogenetic shape change sculpts tissue form while also generating cellular heterogeneity, thereby driving tissue assembly.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coherent evolution of superexchange interaction in seconds-long optical clock spectroscopy 秒长光时钟光谱中超交换相互作用的相干演化
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
William R. Milner, Stefan Lannig, Mikhail Mamaev, Lingfeng Yan, Anjun Chu, Ben Lewis, Max N. Frankel, Ross B. Hutson, Ana Maria Rey, Jun Ye
{"title":"Coherent evolution of superexchange interaction in seconds-long optical clock spectroscopy","authors":"William R. Milner,&nbsp;Stefan Lannig,&nbsp;Mikhail Mamaev,&nbsp;Lingfeng Yan,&nbsp;Anjun Chu,&nbsp;Ben Lewis,&nbsp;Max N. Frankel,&nbsp;Ross B. Hutson,&nbsp;Ana Maria Rey,&nbsp;Jun Ye","doi":"","DOIUrl":"","url":null,"abstract":"<div >Scaling up the performance of atomic clocks requires understanding complex many-body Hamiltonians to ensure meaningful gains for metrological applications. Here we use a degenerate Fermi gas loaded into a three-dimensional optical lattice to study the effect of a tunable Fermi-Hubbard Hamiltonian. The clock laser introduces a spin-orbit coupling spiral phase and breaks the isotropy of superexchange interactions, leading to XXZ-type spin anisotropy. By tuning the lattice confinement and applying imaging spectroscopy, we map out favorable atomic coherence regimes. We transition through various interaction regimes and observe coherent superexchange, tunable through on-site interaction and site-to-site energy shift, affecting the Ramsey fringe contrast over timescales &gt;1 second. This study lays the groundwork for using a three-dimensional optical lattice clock to probe quantum magnetism and spin entanglement.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An uphill grind for wild plant populations 对野生植物种群来说，这是一个艰难的考验
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Sally N. Aitken
{"title":"An uphill grind for wild plant populations","authors":"Sally N. Aitken","doi":"","DOIUrl":"","url":null,"abstract":"<div >The range of temperature and precipitation across which populations remain viable forms the climatic niche for terrestrial life. Many plant (<i>1</i>) and animal (<i>2</i>) species consist of populations that are locally adapted to their preindustrial climates, with each subgroup tolerating a smaller range of climate conditions compared with the whole species (<i>3</i>). Will existing genetic variation be sufficient for the adaptation needed to reverse population decline as climates change (a process known as evolutionary rescue) (<i>4</i>)? Can migration from warmer to cooler regions provide the diversity required for climate adaptation (genetic rescue) (<i>5</i>)? On page 525 of this issue, Anderson <i>et al</i>. (<i>6</i>) report that even for the widely distributed species of the rock cress <i>Boechera stricta</i> in the United States Rocky Mountains, gene flow from warmer to cooler elevations—possibly facilitated by human intervention—is needed to support future survival of some plants in a warming climate.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit 维数减少简化了嗅觉回路中突触伙伴的匹配
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Cheng Lyu, Zhuoran Li, Chuanyun Xu, Kenneth Kin Lam Wong, David J. Luginbuhl, Colleen N. McLaughlin, Qijing Xie, Tongchao Li, Hongjie Li, Liqun Luo
{"title":"Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit","authors":"Cheng Lyu,&nbsp;Zhuoran Li,&nbsp;Chuanyun Xu,&nbsp;Kenneth Kin Lam Wong,&nbsp;David J. Luginbuhl,&nbsp;Colleen N. McLaughlin,&nbsp;Qijing Xie,&nbsp;Tongchao Li,&nbsp;Hongjie Li,&nbsp;Liqun Luo","doi":"","DOIUrl":"","url":null,"abstract":"<div >A navigating axon faces complex choices when selecting postsynaptic partners in a three-dimensional (3D) space. In this work, we discovered a principle that can establish the 3D glomerular map of the fly antennal lobe by reducing the higher dimensionality serially to 1D projections. During development, olfactory receptor neuron (ORN) axons first contact their partner projection neuron dendrites on the spherical surface of the antennal lobe, regardless of whether the adult glomeruli lie near the surface or inside. Along this 2D surface, axons of each ORN type take a specific, arc-shaped trajectory that precisely intersects with their partner dendrites. Altering axon trajectories compromises synaptic partner matching. A 3D search is thus reduced to one dimension, simplifying partner matching.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
North American bird declines are greatest where species are most abundant 在物种最丰富的北美地区，鸟类数量减少最多
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Alison Johnston, Amanda D. Rodewald, Matt Strimas-Mackey, Tom Auer, Wesley M. Hochachka, Andrew N. Stillman, Courtney L. Davis, Viviana Ruiz-Gutierrez, Adriaan M. Dokter, Eliot T. Miller, Orin Robinson, Shawn Ligocki, Lauren Oldham Jaromczyk, Cynthia Crowley, Christopher L. Wood, Daniel Fink
{"title":"North American bird declines are greatest where species are most abundant","authors":"Alison Johnston,&nbsp;Amanda D. Rodewald,&nbsp;Matt Strimas-Mackey,&nbsp;Tom Auer,&nbsp;Wesley M. Hochachka,&nbsp;Andrew N. Stillman,&nbsp;Courtney L. Davis,&nbsp;Viviana Ruiz-Gutierrez,&nbsp;Adriaan M. Dokter,&nbsp;Eliot T. Miller,&nbsp;Orin Robinson,&nbsp;Shawn Ligocki,&nbsp;Lauren Oldham Jaromczyk,&nbsp;Cynthia Crowley,&nbsp;Christopher L. Wood,&nbsp;Daniel Fink","doi":"","DOIUrl":"","url":null,"abstract":"<div >Efforts to address declines of North American birds have been constrained by limited availability of fine-scale information about population change. By using participatory science data from eBird, we estimated continental population change and relative abundance at 27-kilometer resolution for 495 bird species from 2007 to 2021. Results revealed high and previously undetected spatial heterogeneity in trends; although 75% of species were declining, 97% of species showed separate areas of significantly increasing and decreasing populations. Populations tended to decline most steeply in strongholds where species were most abundant, yet they fared better where species were least abundant. These high-resolution trends improve our ability to understand population dynamics, prioritize recovery efforts, and guide conservation at a time when action is urgently needed.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aberrant basal cell clonal dynamics shape early lung carcinogenesis 异常基底细胞克隆动力学影响早期肺癌的发生
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-05-01 DOI: 10.1126/science.ads9145
Sandra Gómez-López, Ahmed S. N. Alhendi, Moritz J. Przybilla, Ignacio Bordeu, Zoe E. Whiteman, Timothy Butler, Maral J. Rouhani, Lukas Kalinke, Imran Uddin, Kate E. J. Otter, Deepak P. Chandrasekharan, Marta Lebrusant-Fernandez, Abigail Y. L. Shurr, Pascal F. Durrenberger, David A. Moore, Mary Falzon, James L. Reading, Iñigo Martincorena, Benjamin D. Simons, Peter J. Campbell, Sam M. Janes
{"title":"Aberrant basal cell clonal dynamics shape early lung carcinogenesis","authors":"Sandra Gómez-López, Ahmed S. N. Alhendi, Moritz J. Przybilla, Ignacio Bordeu, Zoe E. Whiteman, Timothy Butler, Maral J. Rouhani, Lukas Kalinke, Imran Uddin, Kate E. J. Otter, Deepak P. Chandrasekharan, Marta Lebrusant-Fernandez, Abigail Y. L. Shurr, Pascal F. Durrenberger, David A. Moore, Mary Falzon, James L. Reading, Iñigo Martincorena, Benjamin D. Simons, Peter J. Campbell, Sam M. Janes","doi":"10.1126/science.ads9145","DOIUrl":"https://doi.org/10.1126/science.ads9145","url":null,"abstract":"Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no added genetic hits or cell type bias, we find that carcinogen exposure leads to non-neutral competition among basal cells, aberrant clonal expansions, and basal cell mobilization along the airways. Ultimately, preinvasive lesions develop from a few highly mutated clones that dominate most of the bronchial tree. Multi-site sequencing in human patients confirms the presence of clonally related preinvasive lesions across distinct airway regions. Our work identifies a transition in basal cell clonal dynamics, and an associated shift in basal cell fate, as drivers of field cancerization in the lung.","PeriodicalId":21678,"journal":{"name":"Science","volume":"18 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electron collision in a two-path graphene interferometer. 双路石墨烯干涉仪中的电子碰撞。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-05-01 DOI: 10.1126/science.adn4622
H Chakraborti,L Pugliese,A Assouline,K Watanabe,T Taniguchi,N Kumada,D C Glattli,M Jo,H-S Sim,P Roulleau
{"title":"Electron collision in a two-path graphene interferometer.","authors":"H Chakraborti,L Pugliese,A Assouline,K Watanabe,T Taniguchi,N Kumada,D C Glattli,M Jo,H-S Sim,P Roulleau","doi":"10.1126/science.adn4622","DOIUrl":"https://doi.org/10.1126/science.adn4622","url":null,"abstract":"The collision of two electrons at a beam splitter provides a method for studying their coherence and indistinguishability. Its realization requires the on-demand generation and synchronization of single electrons. In this work, we demonstrate the coherent collision of single electrons, generated by voltage pulses, in a graphene Mach-Zehnder interferometer. By measuring shot noise resulting from the collisions, we unveil fundamental characteristics of colliding electrons, highlighting the complementarity between the indistinguishable and distinguishable parts of their wave functions. The former is manifested through fermionic Hong-Ou-Mandel destructive interference, whereas the latter is discerned through double-winding Aharonov-Bohm interference in the noise. The interference visibilities of around 60% enable comprehensive quantum state tomography. Our findings may place coherent operations involving flying qubits within reach in graphene.","PeriodicalId":21678,"journal":{"name":"Science","volume":"48 1","pages":"492-496"},"PeriodicalIF":56.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
China’s pet squirrel trade needs regulation 中国的宠物松鼠贸易需要监管
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Yueqin Yang, Jishan Xiang, Xianfeng Yi
{"title":"China’s pet squirrel trade needs regulation","authors":"Yueqin Yang,&nbsp;Jishan Xiang,&nbsp;Xianfeng Yi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery research in physiologically maintained deceased 研究发现死者的生理维持
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Douglas B. Pet, Brendan Parent, Neel S. Singhal, Claire D. Clelland
{"title":"Discovery research in physiologically maintained deceased","authors":"Douglas B. Pet,&nbsp;Brendan Parent,&nbsp;Neel S. Singhal,&nbsp;Claire D. Clelland","doi":"","DOIUrl":"","url":null,"abstract":"<div >Deceased humans in whom ventilation and circulation are maintained for a defined period after the declaration of death by neurologic criteria (brain death), referred to here as physiologically maintained deceased (PMD), mimic live human physiology, providing highly valuable research opportunities. Medical research involving PMDs has narrowed translational gaps and ushered in groundbreaking treatments, including the transplantation of gene-edited organs into living human patients (<i>1</i>). However, the potential of PMDs remains largely untapped for human therapeutic discovery research. PMDs may be particularly advantageous in discovering and advancing new therapies, such as gene therapies, that are human specific and therefore are limited by nonhuman research models. We envision PMD research as a transformative force for human therapeutic discovery and emphasize the importance of upholding established bioethical standards and pursuing ongoing ethical inquiry to ensure the protection of all stakeholders.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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