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In Science Journals 在科学期刊上
IF 47.3 1区 综合性期刊
Science Pub Date : 2026-10-15 DOI: 10.1126/science.aen1236
Jesse Smith, Jelena Stajic, Ian S. Osborne, Jake S. Yeston, Marc S. Lavine, Annalisa VanHook, Seth Thomas Scanlon, Unnati Sonawala, Madeleine Seale, Mattia Maroso, Stella M. Hurtley, L. Bryan Ray, Yury Suleymanov, Sacha Vignieri
{"title":"In Science Journals","authors":"Jesse Smith, Jelena Stajic, Ian S. Osborne, Jake S. Yeston, Marc S. Lavine, Annalisa VanHook, Seth Thomas Scanlon, Unnati Sonawala, Madeleine Seale, Mattia Maroso, Stella M. Hurtley, L. Bryan Ray, Yury Suleymanov, Sacha Vignieri","doi":"10.1126/science.aen1236","DOIUrl":"10.1126/science.aen1236","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"394 6821","pages":""},"PeriodicalIF":47.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.aen1236","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fear the bioengineered future 害怕生物工程的未来
IF 47.3 1区 综合性期刊
Science Pub Date : 2026-10-15 DOI: 10.1126/science.aem4081
Gregory J. Miller
{"title":"Fear the bioengineered future","authors":"Gregory J. Miller","doi":"10.1126/science.aem4081","DOIUrl":"10.1126/science.aem4081","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"394 6821","pages":""},"PeriodicalIF":47.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Market dilution, fair use, and generative AI 市场稀释、合理使用和生成式人工智能
IF 47.3 1区 综合性期刊
Science Pub Date : 2026-10-15 DOI: 10.1126/science.ael4888
Pamela Samuelson, Abhishek Nagaraj, Christopher Jon Sprigman
{"title":"Market dilution, fair use, and generative AI","authors":"Pamela Samuelson, Abhishek Nagaraj, Christopher Jon Sprigman","doi":"10.1126/science.ael4888","DOIUrl":"10.1126/science.ael4888","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"394 6821","pages":""},"PeriodicalIF":47.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.ael4888","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Keeping time in the crypt 在地窖里保持时间
IF 47.3 1区 综合性期刊
Science Pub Date : 2026-10-15 DOI: 10.1126/science.ael9313
Stephanie J. Ellis
{"title":"Keeping time in the crypt","authors":"Stephanie J. Ellis","doi":"10.1126/science.ael9313","DOIUrl":"10.1126/science.ael9313","url":null,"abstract":"<div >To maintain homeostasis, barrier epithelia—the body’s first line of defense—undergo constant, rapid turnover. This includes the inner surface of the mammalian intestine, where ongoing regeneration protects against daily wear and tear, preventing dangerous breaches and supporting gut health. The correct proportion of cell types is maintained throughout lifetimes, ensuring that form and function are preserved. Although the signaling pathways required for this balance are known, it has been unclear how their inputs are tuned to appropriately apportion cell fates (<i>1</i>–<i>3</i>). On page 289 of this issue, Weterings <i>et al.</i> (<i>4</i>) report that cell type specification is encoded by the frequency of oscillations in expression of the transcription factor Hes1 (hairy and enhancer of split 1). They found that distinct oscillation time periods tracked with specific cell identities and that oscillating signaling dynamics, known to play a role in developmental processes, appear to control homeostatic processes as well.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"394 6821","pages":""},"PeriodicalIF":47.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frequency encoding regulates cell type composition in the small intestine 频率编码调节小肠中的细胞类型组成
IF 47.3 1区 综合性期刊
Science Pub Date : 2026-10-15 DOI: 10.1126/science.adt1928
Sonja D. C. Weterings, Hiromune Eto, Jan-Daniël de Leede-Scheven, Amir Giladi, Jooske L. Monster, Mirjam E. Hoekstra, Wouter F. Beijk, Esther J. M. Liefting, Karen B. van den Anker, Jacco van Rheenen, Alexander van Oudenaarden, Katharina F. Sonnen
{"title":"Frequency encoding regulates cell type composition in the small intestine","authors":"Sonja D. C. Weterings,&nbsp;Hiromune Eto,&nbsp;Jan-Daniël de Leede-Scheven,&nbsp;Amir Giladi,&nbsp;Jooske L. Monster,&nbsp;Mirjam E. Hoekstra,&nbsp;Wouter F. Beijk,&nbsp;Esther J. M. Liefting,&nbsp;Karen B. van den Anker,&nbsp;Jacco van Rheenen,&nbsp;Alexander van Oudenaarden,&nbsp;Katharina F. Sonnen","doi":"10.1126/science.adt1928","DOIUrl":"10.1126/science.adt1928","url":null,"abstract":"<div >Intestinal homeostasis requires tight regulation of stem cell maintenance and differentiation to absorptive and secretory cell types, two major intestinal lineages. Key signaling pathways have been identified, but how they balance cell type composition remains unclear. We uncovered oscillatory expression of the Notch-target protein Hes1 (hairy and enhancer of split 1) that controls cell fate specification in a frequency-dependent manner. An endogenous fluorescent Hes1 reporter revealed distinct, cell type–specific oscillation frequencies forming a gradient along the crypt-villus axis, which was modulated by cell cycle phase as well as Wnt (wingless-related integration site)–signaling and Notch-signaling activity. We developed a microfluidic system to modulate Notch-signaling oscillations in organoids and found the oscillation frequency to regulate the balance of cell type composition. This study provides evidence that information for cell fate specification is encoded in the frequency of an oscillatory signal.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"394 6821","pages":""},"PeriodicalIF":47.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of target gene expression by chromatin-associated protein-coding transcripts in plants 植物染色质相关蛋白编码转录物对靶基因表达的调控
IF 47.3 1区 综合性期刊
Science Pub Date : 2026-10-15 DOI: 10.1126/science.adz4903
Lu Han, Yuxiang Yuan, Yujie Liu, Yan Li, Yijun Qi
{"title":"Regulation of target gene expression by chromatin-associated protein-coding transcripts in plants","authors":"Lu Han,&nbsp;Yuxiang Yuan,&nbsp;Yujie Liu,&nbsp;Yan Li,&nbsp;Yijun Qi","doi":"10.1126/science.adz4903","DOIUrl":"10.1126/science.adz4903","url":null,"abstract":"<div >Protein-coding transcripts are regarded as intermediates that mediate DNA-to-protein information flow, leaving their noncoding regulatory potential largely underappreciated. Genome-wide profiling of RNA–chromatin interactions in <i>Arabidopsis</i> has uncovered widespread associations between protein-coding transcripts and distinct genomic loci, implying that they possess regulatory functions. Here, we found that <i>BT2</i> and <i>GSL8</i> transcripts modulate target gene transcription independently of their protein products through distinct mechanisms. The <i>BT2</i> transcript represses transcription of its targets <i>CEP2</i> and <i>MRF4</i> by forming RNA–DNA triplexes, thereby restricting root growth and promoting flowering, whereas <i>GSL8</i> acts through a triplex-independent pathway. Our findings unveil intrinsic regulatory activities of protein-coding transcripts, challenging the canonical definition of mRNA function and blurring the functional distinction between coding and noncoding RNAs in the context of genome evolution.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"394 6821","pages":""},"PeriodicalIF":47.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medications in addiction recovery—a clash of science and stigma 成瘾康复中的药物治疗——科学与耻辱的冲突
IF 47.3 1区 综合性期刊
Science Pub Date : 2026-10-15 DOI: 10.1126/science.aem0383
John Strang
{"title":"Medications in addiction recovery—a clash of science and stigma","authors":"John Strang","doi":"10.1126/science.aem0383","DOIUrl":"10.1126/science.aem0383","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"394 6821","pages":""},"PeriodicalIF":47.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modular van der Waals MOSFETs through layer-by-layer chalcogen substitutions 通过逐层碳置换的模块化范德华mosfet
IF 47.3 1区 综合性期刊
Science Pub Date : 2026-10-15 DOI: 10.1126/science.aei2693
Seok Young Min, Hyunje Cho, Suk-Ho Lee, Jaeho Choi, Taeho Kim, Jong Yun Choi, Heewon Park, Junsoo Yoon, TaeJoon Mo, Chumki Nayak, Gi-Yeop Kim, Sung-Hyuk Her, Chul-Ho Lee, Yong-Sung Kim, Si-Young Choi, Cheol-Joo Kim, Moon-Ho Jo
{"title":"Modular van der Waals MOSFETs through layer-by-layer chalcogen substitutions","authors":"Seok Young Min,&nbsp;Hyunje Cho,&nbsp;Suk-Ho Lee,&nbsp;Jaeho Choi,&nbsp;Taeho Kim,&nbsp;Jong Yun Choi,&nbsp;Heewon Park,&nbsp;Junsoo Yoon,&nbsp;TaeJoon Mo,&nbsp;Chumki Nayak,&nbsp;Gi-Yeop Kim,&nbsp;Sung-Hyuk Her,&nbsp;Chul-Ho Lee,&nbsp;Yong-Sung Kim,&nbsp;Si-Young Choi,&nbsp;Cheol-Joo Kim,&nbsp;Moon-Ho Jo","doi":"10.1126/science.aei2693","DOIUrl":"10.1126/science.aei2693","url":null,"abstract":"<div >In two-dimensional transition-metal dichalcogenides (TMDCs), the local electrostatic field of the chalcogen <i>p</i>-orbitals dictates the crystal field splitting of the transition metal <i>d</i>-orbitals, stabilizing diverse electronic states from semiconducting and semimetallic to exotic topological phases. On-demand substitution of the lattice chalcogens is therefore an efficient route to tuning TMDC electronic phases. Here, we custom-molded van der Waals (vdW) heterostructures by layer-by-layer vapor-phase chalcogen substitution starting from <i>p</i>-type WSe<sub>2</sub> multilayers into which we locally inscribed insulating WO<i><sub>x</sub></i>, <i>n</i>-type WS<sub>2</sub>, and semimetallic WTe<sub>2</sub>. This spatially precise conversion seamlessly integrated distinct electronic phases, both vertically and laterally, into modular vdW semiconductor heterostructures that are otherwise inaccessible. As a demonstration, we integrated WO<i><sub>x</sub></i>/WSe<sub>2</sub> local gate stacks to build ultrascaled metal oxide–semiconductor field effect transistors (MOSFETs), achieving an unprecedented subthreshold swing at subnanometer equivalent oxide thickness.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"394 6821","pages":""},"PeriodicalIF":47.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atomic functional site scaffolding in biopolymers with RFdiffusion3 基于射频扩散的生物聚合物原子功能位点脚手架研究
IF 56.9 1区 综合性期刊
Science Pub Date : 2026-10-15 DOI: 10.1126/science.aeh2982
Jasper Butcher, Rohith Krishna, Raktim Mitra, Seth M. Woodbury, Donghyo Kim, Rafael I. Brent, Yanjing Li, Nathaniel Corley, Andrew Favor, Anqi Chen, Paul T. Kim, Jonathan Funk, Gabriela Bastidas Reinoso, Kejia Wu, Aiko Muraishi, Helen E. Eisenach, Saman Salike, Simon Mathis, Tuscan Rock Thompson, Antonia Ruder, Enisha Sehgal, Andrew Kubaney, Jie Chen, Yuliya Politanska, Brian Coventry, Odin Zhang, Florence J. Hardy, Bo Qiang, Kieran Didi, Maxwell Kazman, Lars L. Schaaf, Frank DiMaio, David Baker
{"title":"Atomic functional site scaffolding in biopolymers with RFdiffusion3","authors":"Jasper Butcher, Rohith Krishna, Raktim Mitra, Seth M. Woodbury, Donghyo Kim, Rafael I. Brent, Yanjing Li, Nathaniel Corley, Andrew Favor, Anqi Chen, Paul T. Kim, Jonathan Funk, Gabriela Bastidas Reinoso, Kejia Wu, Aiko Muraishi, Helen E. Eisenach, Saman Salike, Simon Mathis, Tuscan Rock Thompson, Antonia Ruder, Enisha Sehgal, Andrew Kubaney, Jie Chen, Yuliya Politanska, Brian Coventry, Odin Zhang, Florence J. Hardy, Bo Qiang, Kieran Didi, Maxwell Kazman, Lars L. Schaaf, Frank DiMaio, David Baker","doi":"10.1126/science.aeh2982","DOIUrl":"https://doi.org/10.1126/science.aeh2982","url":null,"abstract":"The catalytic and other sophisticated functions of biomolecules arise from the placement of many atoms in three-dimensional space. Here, we describe a generative artificial intelligence method for biopolymers, RFdiffusion3 (RFD3), which employs free atom diffusion to satisfy complex sets of atomic constraints more rapidly and accurately than previous methods across several challenges from enzyme design to RNA structure design. We demonstrate experimentally the power of the RFD3 pipeline for enzyme design by designing de novo phosphotriesterases with a complex active site architecture incorporating a carbamylated lysine coordinating two metal ions and zinc proteases specific for the transthyretin protein involved in amyloid diseases; in both cases we obtain active catalysts in zero shot 96 construct design campaigns.","PeriodicalId":21678,"journal":{"name":"Science","volume":"13 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'Super' El Niño spurs research on ecosystem impacts. “超级”厄尔尼诺Niño刺激了对生态系统影响的研究。
IF 47.3 1区 综合性期刊
Science Pub Date : 2026-10-15 DOI: 10.1126/science.aen2357
Warren Cornwall
{"title":"'Super' El Niño spurs research on ecosystem impacts.","authors":"Warren Cornwall","doi":"10.1126/science.aen2357","DOIUrl":"https://doi.org/10.1126/science.aen2357","url":null,"abstract":"<p><p>This year's event could shed light on how the natural world may respond to climate change in the decades ahead.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"394 6821","pages":"257-258"},"PeriodicalIF":47.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149196230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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