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China’s pet squirrel trade needs regulation 中国的宠物松鼠贸易需要监管
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Yueqin Yang, Jishan Xiang, Xianfeng Yi
{"title":"China’s pet squirrel trade needs regulation","authors":"Yueqin Yang, Jishan Xiang, Xianfeng Yi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery research in physiologically maintained deceased 研究发现死者的生理维持
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Douglas B. Pet, Brendan Parent, Neel S. Singhal, Claire D. Clelland
{"title":"Discovery research in physiologically maintained deceased","authors":"Douglas B. Pet,&nbsp;Brendan Parent,&nbsp;Neel S. Singhal,&nbsp;Claire D. Clelland","doi":"","DOIUrl":"","url":null,"abstract":"<div >Deceased humans in whom ventilation and circulation are maintained for a defined period after the declaration of death by neurologic criteria (brain death), referred to here as physiologically maintained deceased (PMD), mimic live human physiology, providing highly valuable research opportunities. Medical research involving PMDs has narrowed translational gaps and ushered in groundbreaking treatments, including the transplantation of gene-edited organs into living human patients (<i>1</i>). However, the potential of PMDs remains largely untapped for human therapeutic discovery research. PMDs may be particularly advantageous in discovering and advancing new therapies, such as gene therapies, that are human specific and therefore are limited by nonhuman research models. We envision PMD research as a transformative force for human therapeutic discovery and emphasize the importance of upholding established bioethical standards and pursuing ongoing ethical inquiry to ensure the protection of all stakeholders.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Universal distributed blind quantum computing with solid-state qubits 基于固态量子比特的通用分布式盲量子计算
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Y.-C. Wei, P.-J. Stas, A. Suleymanzade, G. Baranes, F. Machado, Y. Q. Huan, C. M. Knaut, S. W. Ding, M. Merz, E. N. Knall, U. Yazlar, M. Sirotin, I. W. Wang, B. Machielse, S. F. Yelin, J. Borregaard, H. Park, M. Lončar, M. D. Lukin
{"title":"Universal distributed blind quantum computing with solid-state qubits","authors":"Y.-C. Wei,&nbsp;P.-J. Stas,&nbsp;A. Suleymanzade,&nbsp;G. Baranes,&nbsp;F. Machado,&nbsp;Y. Q. Huan,&nbsp;C. M. Knaut,&nbsp;S. W. Ding,&nbsp;M. Merz,&nbsp;E. N. Knall,&nbsp;U. Yazlar,&nbsp;M. Sirotin,&nbsp;I. W. Wang,&nbsp;B. Machielse,&nbsp;S. F. Yelin,&nbsp;J. Borregaard,&nbsp;H. Park,&nbsp;M. Lončar,&nbsp;M. D. Lukin","doi":"","DOIUrl":"","url":null,"abstract":"<div >Blind quantum computing is a promising application of distributed quantum systems, in which a client can perform computations on a remote server without revealing any details of the applied circuit. Although the most promising realizations of quantum computers are based on various matter-qubit platforms, implementing blind quantum computing on matter qubits remains a challenge. Using silicon-vacancy (SiV) centers in nanophotonic diamond cavities with an efficient optical interface, we demonstrated a universal quantum gate set consisting of single- and two-qubit blind gates over a distributed two-node network. Using these ingredients, we performed a distributed algorithm with blind operations across our two-node network, proving a route to develop blind quantum computation with matter qubits in distributed, modular architectures.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electron collision in a two-path graphene interferometer 双路石墨烯干涉仪中的电子碰撞
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
H. Chakraborti, L. Pugliese, A. Assouline, K. Watanabe, T. Taniguchi, N. Kumada, D. C. Glattli, M. Jo, H.-S. Sim, P. Roulleau
{"title":"Electron collision in a two-path graphene interferometer","authors":"H. Chakraborti,&nbsp;L. Pugliese,&nbsp;A. Assouline,&nbsp;K. Watanabe,&nbsp;T. Taniguchi,&nbsp;N. Kumada,&nbsp;D. C. Glattli,&nbsp;M. Jo,&nbsp;H.-S. Sim,&nbsp;P. Roulleau","doi":"","DOIUrl":"","url":null,"abstract":"<div >The collision of two electrons at a beam splitter provides a method for studying their coherence and indistinguishability. Its realization requires the on-demand generation and synchronization of single electrons. In this work, we demonstrate the coherent collision of single electrons, generated by voltage pulses, in a graphene Mach-Zehnder interferometer. By measuring shot noise resulting from the collisions, we unveil fundamental characteristics of colliding electrons, highlighting the complementarity between the indistinguishable and distinguishable parts of their wave functions. The former is manifested through fermionic Hong-Ou-Mandel destructive interference, whereas the latter is discerned through double-winding Aharonov-Bohm interference in the noise. The interference visibilities of around 60% enable comprehensive quantum state tomography. Our findings may place coherent operations involving flying qubits within reach in graphene.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The post-truth era and how science education keeps ignoring it 后真相时代以及科学教育如何一直忽视它
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Sibel Erduran
{"title":"The post-truth era and how science education keeps ignoring it","authors":"Sibel Erduran","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An uphill grind for wild plant populations. 对野生植物种群来说，这是一个艰难的考验。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-05-01 DOI: 10.1126/science.adx5165
Sally N Aitken
{"title":"An uphill grind for wild plant populations.","authors":"Sally N Aitken","doi":"10.1126/science.adx5165","DOIUrl":"https://doi.org/10.1126/science.adx5165","url":null,"abstract":"Genetic variation is inadequate for the adaptation of a montane plant to new climates.","PeriodicalId":21678,"journal":{"name":"Science","volume":"58 1","pages":"469-470"},"PeriodicalIF":56.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thriving in perilous times 险象环生
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Erle C. Ellis
{"title":"Thriving in perilous times","authors":"Erle C. Ellis","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mechanics behind the beauty of roses 玫瑰美丽背后的机械原理
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Qinghao Cui, Lishuai Jin
{"title":"The mechanics behind the beauty of roses","authors":"Qinghao Cui,&nbsp;Lishuai Jin","doi":"","DOIUrl":"","url":null,"abstract":"<div >Nature’s artistry in shaping living forms often arises from the delicate interplay between growth and geometry. From the undulating margins of lotus leaves to rippled edges of lily petals, intricate three-dimensional configurations emerge as biological tissues grow unevenly from the initial two-dimensional geometry. For decades, Gauss’s Theorema Egregium—a geometrical theory that links intrinsic curvature of a surface to measurements of its distance and angle—has served as the cornerstone for understanding such morphogenesis (<i>1</i>, <i>2</i>). On page 520 of this issue, Zhang <i>et al</i>. (<i>3</i>) report a distinct mechanism underlying the formation of sharp cusps of rose petals that deviates from this classical incompatibility. This discovery reframes understanding of how geometrical constraints sculpt biological forms and opens new avenues for engineering shape-shifting materials.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense 细菌逆转录酶合成富含多聚a的长cDNA用于抗噬菌体防御
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-05-01 DOI: 10.1126/science.ads4639
Xin-Yi Song, Yushan Xia, Jun-Tao Zhang, Yu-Jun Liu, Hua Qi, Xin-Yang Wei, Hailiang Hu, Yu Xia, Xue Liu, Ying-Fei Ma, Ning Jia
{"title":"Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense","authors":"Xin-Yi Song, Yushan Xia, Jun-Tao Zhang, Yu-Jun Liu, Hua Qi, Xin-Yang Wei, Hailiang Hu, Yu Xia, Xue Liu, Ying-Fei Ma, Ning Jia","doi":"10.1126/science.ads4639","DOIUrl":"https://doi.org/10.1126/science.ads4639","url":null,"abstract":"Prokaryotic defense-associated reverse transcriptases (DRTs) were recently identified with antiviral functions; however, their functional mechanisms remain largely unexplored. Here we show that DRT9 forms a hexameric complex with its upstream non-coding RNA (ncRNA) to mediate antiphage defense by inducing cell growth arrest via abortive infection. Upon phage infection, the phage-encoded ribonucleotide reductase NrdAB complex elevates intracellular dATP levels, activating DRT9 to synthesize long, poly-A-rich single-stranded cDNA, which likely sequesters the essential phage SSB protein and disrupts phage propagation. We further determined the cryo-electron microscopy structure of the DRT9-ncRNA hexamer complex, providing mechanistic insights into its cDNA synthesis. These findings highlight the diversity of RT-based antiviral defense mechanisms, expand our understanding of RT biological functions, and provide a structural basis for developing DRT9-based biotechnological tools.","PeriodicalId":21678,"journal":{"name":"Science","volume":"136 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins 细胞内蛋白编辑使内源性蛋白中的非规范残基得以整合
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Jenna N. Beyer, Yevgeniy V. Serebrenik, Kaitlyn Toy, Mohd. Altaf Najar, Emily Feierman, Nicole R. Raniszewski, Erica Korb, Ophir Shalem, George M. Burslem
{"title":"Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins","authors":"Jenna N. Beyer,&nbsp;Yevgeniy V. Serebrenik,&nbsp;Kaitlyn Toy,&nbsp;Mohd. Altaf Najar,&nbsp;Emily Feierman,&nbsp;Nicole R. Raniszewski,&nbsp;Erica Korb,&nbsp;Ophir Shalem,&nbsp;George M. Burslem","doi":"","DOIUrl":"","url":null,"abstract":"<div >The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split intein–mediated protein splicing, genetic code expansion, and endogenous protein tagging. This approach enables us to rapidly and site-specifically install residues and chemical handles into a protein. We demonstrate the power of this platform to edit cellular proteins, inserting epitopes, protein-specific sequences, and noncanonical amino acids. Notably, we use an endogenous tagging approach to apply our protein editing technology to endogenous proteins with minimal perturbation. We anticipate that the protein editing technology presented in this work will be applied to a diverse set of problems and phenomena in live mammalian cells.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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