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AI map reveals vast scope of 'ghost forests' along east coast of U.S. 人工智能地图揭示了美国东海岸广阔的“幽灵森林”
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aec7428
James Dinneen
{"title":"AI map reveals vast scope of 'ghost forests' along east coast of U.S.","authors":"James Dinneen","doi":"10.1126/science.aec7428","DOIUrl":"https://doi.org/10.1126/science.aec7428","url":null,"abstract":"Machine learning method counts nearly 12 million dead trees, many likely killed by rising seas.","PeriodicalId":21678,"journal":{"name":"Science","volume":"19 1","pages":"14-15"},"PeriodicalIF":56.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Climate-linked escalation of societally disastrous wildfires 与气候相关的社会灾难性野火升级
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.adr5127
Calum X. Cunningham, John T. Abatzoglou, Crystal A. Kolden, Grant J. Williamson, Markus Steuer, David M. J. S. Bowman
{"title":"Climate-linked escalation of societally disastrous wildfires","authors":"Calum X. Cunningham,&nbsp;John T. Abatzoglou,&nbsp;Crystal A. Kolden,&nbsp;Grant J. Williamson,&nbsp;Markus Steuer,&nbsp;David M. J. S. Bowman","doi":"10.1126/science.adr5127","DOIUrl":"10.1126/science.adr5127","url":null,"abstract":"<div >Climate change and land mismanagement are creating increasingly fire-prone built and natural environments. However, despite worsening fire seasons, evidence is lacking globally for trends in socially and economically disastrous wildfires, partly due to sparse systematic records. Using a 44-year dataset (1980 to 2023) we analyze the distribution, trends, and climatic conditions connected with the most lethal and costly wildfires. Disastrous wildfires occurred globally over this period but were concentrated in the Mediterranean and temperate conifer biomes. Disaster risk was highest where highly energetic daily fire events intersected affluent, populated areas. Economic disasters increased sharply from 2015 onward, with 43% of the 200 most damaging events occurring in the last decade. Disasters coincided with increasingly extreme climatic conditions, highlighting the urgent need to adapt to a more fire-prone world.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New museum bolsters China's controversial claim to Pacific languages. 新博物馆支持中国对太平洋语言有争议的主张。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aec7430
Marcel Hobma
{"title":"New museum bolsters China's controversial claim to Pacific languages.","authors":"Marcel Hobma","doi":"10.1126/science.aec7430","DOIUrl":"https://doi.org/10.1126/science.aec7430","url":null,"abstract":"Nationalist narrative holds that Austronesian language and culture originated in China, not Taiwan.","PeriodicalId":21678,"journal":{"name":"Science","volume":"98 1","pages":"16"},"PeriodicalIF":56.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In a first, a gene therapy seems to slow Huntington disease. 基因疗法似乎首次减缓了亨廷顿病。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aec7429
Jocelyn Kaiser
{"title":"In a first, a gene therapy seems to slow Huntington disease.","authors":"Jocelyn Kaiser","doi":"10.1126/science.aec7429","DOIUrl":"https://doi.org/10.1126/science.aec7429","url":null,"abstract":"Small study suggests uniQure drug could be first successful treatment for devastating brain disorder.","PeriodicalId":21678,"journal":{"name":"Science","volume":"10 1","pages":"15"},"PeriodicalIF":56.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Observation of undepleted phosphine in the atmosphere of a low-temperature brown dwarf 低温褐矮星大气中未耗尽磷化氢的观测
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.adu0401
Adam J. Burgasser, Eileen C. Gonzales, Samuel A. Beiler, Channon Visscher, Ben Burningham, Gregory N. Mace, Jacqueline K. Faherty, Zenghua Zhang, Clara Sousa-Silva, Nicolas Lodieu, Stanimir A. Metchev, Aaron Meisner, Michael Cushing, Adam C. Schneider, Genaro Suarez, Chih-Chun Hsu, Roman Gerasimov, Christian Aganze, Christopher A. Theissen
{"title":"Observation of undepleted phosphine in the atmosphere of a low-temperature brown dwarf","authors":"Adam J. Burgasser, Eileen C. Gonzales, Samuel A. Beiler, Channon Visscher, Ben Burningham, Gregory N. Mace, Jacqueline K. Faherty, Zenghua Zhang, Clara Sousa-Silva, Nicolas Lodieu, Stanimir A. Metchev, Aaron Meisner, Michael Cushing, Adam C. Schneider, Genaro Suarez, Chih-Chun Hsu, Roman Gerasimov, Christian Aganze, Christopher A. Theissen","doi":"10.1126/science.adu0401","DOIUrl":"https://doi.org/10.1126/science.adu0401","url":null,"abstract":"The atmospheres of low-temperature brown dwarfs and gas giant planets are expected to contain the phosphine molecule, PH <jats:sub>3</jats:sub> . However, previous observations have shown much lower abundances of this molecule than predicted by atmospheric chemistry models. We report JWST spectroscopic observations of phosphine in the atmosphere of the brown dwarf Wolf 1130C. Multiple absorption lines due to phosphine are detected around 4.3 μm, from which we calculate a phosphine abundance of 0.100 ± 0.009 parts per million. This abundance is consistent with disequilibrium atmospheric chemistry models that reproduce the phosphine abundances in Jupiter and Saturn, and is much higher than abundances previously reported for other brown dwarfs or exoplanets. This difference may be related to the low abundance of elements heavier than helium in Wolf 1130C.","PeriodicalId":21678,"journal":{"name":"Science","volume":"19 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive genetic catalog of human double-strand break repair 人类双链断裂修复的综合基因目录
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.adr5048
Ernesto López de Alba, Israel Salguero, Daniel Giménez-Llorente, Javier Montes-Torres, Ángel Fernández-Sanromán, Ester Casajús-Pelegay, José Terrón-Bautista, Jonathan Barroso-González, Juan A. Bernal, Geoff Macintyre, Rafael Fernández-Leiro, Ana Losada, Felipe Cortés-Ledesma
{"title":"A comprehensive genetic catalog of human double-strand break repair","authors":"Ernesto López de Alba,&nbsp;Israel Salguero,&nbsp;Daniel Giménez-Llorente,&nbsp;Javier Montes-Torres,&nbsp;Ángel Fernández-Sanromán,&nbsp;Ester Casajús-Pelegay,&nbsp;José Terrón-Bautista,&nbsp;Jonathan Barroso-González,&nbsp;Juan A. Bernal,&nbsp;Geoff Macintyre,&nbsp;Rafael Fernández-Leiro,&nbsp;Ana Losada,&nbsp;Felipe Cortés-Ledesma","doi":"10.1126/science.adr5048","DOIUrl":"10.1126/science.adr5048","url":null,"abstract":"<div >The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels) within a genome-wide knockout library, we present a comprehensive catalog that assesses the influence of nearly every human gene on DSB repair outcomes. This REPAIRome resource uncovers uncharacterized mechanisms, pathways, and factors involved in DSB repair, including opposing roles for XLF and PAXX, a molecular explanation for Cas9-induced multinucleotide insertions, HLTF functions in Cas9-induced DSB repair, the involvement of the SAGA complex in microhomology-mediated end joining, and an indel mutational signature linked to VHL loss, renal carcinoma, and hypoxia. These results exemplify the potential of REPAIRome to drive future discoveries in DSB repair, CRISPR-Cas gene editing and the etiology of cancer mutational signatures.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ambitious collaboration will map primate brains-including ours-in unprecedented detail. 雄心勃勃的合作将以前所未有的细节绘制灵长类动物的大脑图谱——包括我们的大脑。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aec7427
Richard Stone
{"title":"Ambitious collaboration will map primate brains-including ours-in unprecedented detail.","authors":"Richard Stone","doi":"10.1126/science.aec7427","DOIUrl":"https://doi.org/10.1126/science.aec7427","url":null,"abstract":"25-year plan will tap brain-mapping prowess in China and two dozen other countries.","PeriodicalId":21678,"journal":{"name":"Science","volume":"19 1","pages":"12-13"},"PeriodicalIF":56.9,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145209025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Getting to the root of the pattern 找到这种模式的根源
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aeb6058
Ekaterina Kozaeva, Jennifer A. N. Brophy
{"title":"Getting to the root of the pattern","authors":"Ekaterina Kozaeva,&nbsp;Jennifer A. N. Brophy","doi":"10.1126/science.aeb6058","DOIUrl":"10.1126/science.aeb6058","url":null,"abstract":"<div >For more than a century, scientists have puzzled over how bacteria colonize plant roots and what this colonization means for plant health. Early discoveries, such as the identification of nitrogen-fixing bacteria in the roots of legumes, seeded the modern view that plants orchestrate interactions with their microbial partners. Yet many aspects of how plants manage these relationships remain unclear. On page 44 of this issue, Tsai <i>et al.</i> report that the CHA0 strain of <i>Pseudomonas protegens</i>, a plant growth–promoting bacterium that is commonly used to protect plants from fungal pathogens and insects, is attracted to areas of the root where the amino acid glutamine leaks out (<i>1</i>). This leakage occurs at breaks or natural endpoints in the Casparian strip, a barrier that normally restricts diffusion across root tissues. Their findings highlight how root anatomy can influence the pattern of microbial colonization along plant roots.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On prosthetics, printed organs, and pig hearts 假肢，打印器官，还有猪心脏
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aeb2381
Christopher Kemp
{"title":"On prosthetics, printed organs, and pig hearts","authors":"Christopher Kemp","doi":"10.1126/science.aeb2381","DOIUrl":"10.1126/science.aeb2381","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Battery charging goes quantum 电池充电走向量子化
IF 45.8 1区 综合性期刊
Science Pub Date : 2025-10-02 DOI: 10.1126/science.aeb4825
Robert E. Warburton
{"title":"Battery charging goes quantum","authors":"Robert E. Warburton","doi":"10.1126/science.aeb4825","DOIUrl":"10.1126/science.aeb4825","url":null,"abstract":"<div >Rechargeable lithium-ion batteries power consumer electronics and electric vehicles, making them an essential component of the modern economy. Although lithium-ion battery technology has improved continuously over the past decades, widespread adoption of electrified transportation requires charging in less than 15 min to be competitive with internal combustion engines. As a battery charges and discharges, lithium ions travel across the electrode-electrolyte interface. The rate at which lithium ions transfer is dictated by the structure and physical properties of electrolytes and lithium-storing electrodes. Yet, the exact chemical reaction mechanism underlying the insertion of lithium ions at the electrode-electrolyte interface remains elusive. On page 46 of this issue, Zhang <i>et al</i>. (<i>1</i>) report experimental evidence that shows that lithium-ion battery charge and discharge occur through a coupled ion-electron transfer mechanism. This could establish an experimental and theoretical platform to extract key parameters for optimizing charge transfer rates in lithium-ion batteries.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"390 6768","pages":""},"PeriodicalIF":45.8,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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