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Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice
IF 56.9 1区 综合性期刊
Science Pub Date : 2024-12-19 DOI: 10.1126/science.adp6547
Wenwen Li, Jiarui Li, Jing Li, Chen Wei, Tal Laviv, Meiyi Dong, Jingran Lin, Mariah Calubag, Lesley A Colgan, Kai Jin, Bing Zhou, Ying Shen, Haohong Li, Yihui Cui, Zhihua Gao, Tao Li, Hailan Hu, Ryohei Yasuda, Huan Ma
{"title":"Boosting neuronal activity-driven mitochondrial DNA transcription improves cognition in aged mice","authors":"Wenwen Li, Jiarui Li, Jing Li, Chen Wei, Tal Laviv, Meiyi Dong, Jingran Lin, Mariah Calubag, Lesley A Colgan, Kai Jin, Bing Zhou, Ying Shen, Haohong Li, Yihui Cui, Zhihua Gao, Tao Li, Hailan Hu, Ryohei Yasuda, Huan Ma","doi":"10.1126/science.adp6547","DOIUrl":"https://doi.org/10.1126/science.adp6547","url":null,"abstract":"Deciphering the complex interplay between neuronal activity and mitochondrial function is pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic function and mitochondrial performance. Here, we identified an age-dependent coupling between neuronal and synaptic excitation and mitochondrial DNA transcription (E-TC <jats:sub>mito</jats:sub> ), which operates differently compared to classic excitation-transcription coupling in the nucleus (E-TC <jats:sub>nuc</jats:sub> ). We demonstrated that E-TC <jats:sub>mito</jats:sub> repurposes molecules traditionally associated with E-TC <jats:sub>nuc</jats:sub> to regulate mitochondrial DNA expression in areas closely linked to synaptic activation. The effectiveness of E-TC <jats:sub>mito</jats:sub> weakens with age, contributing to age-related neurological deficits in mice. Boosting brain E-TC <jats:sub>mito</jats:sub> in aged animals ameliorated these impairments, offering a potential target to counteract age-related cognitive decline.","PeriodicalId":21678,"journal":{"name":"Science","volume":"42 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bright, circularly polarized black-body radiation from twisted nanocarbon filaments
IF 56.9 1区 综合性期刊
Science Pub Date : 2024-12-19 DOI: 10.1126/science.adq4068
Jun Lu, Hong Ju Jung, Ji-Young Kim, Nicholas A. Kotov
{"title":"Bright, circularly polarized black-body radiation from twisted nanocarbon filaments","authors":"Jun Lu, Hong Ju Jung, Ji-Young Kim, Nicholas A. Kotov","doi":"10.1126/science.adq4068","DOIUrl":"https://doi.org/10.1126/science.adq4068","url":null,"abstract":"Planck’s law ignores but does not prohibit black-body radiation (BBR) from being circularly polarized. BBR from nanostructured filaments with twisted geometry from nanocarbon or metal has strong ellipticity from 500 to 3000 nanometers. The submicrometer-scale chirality of these filaments satisfies the dimensionality requirements imposed by fluctuation-dissipation theorem and requires symmetry breaking in absorptivity and emissivity according to Kirchhoff’s law. The resulting BBR shows emission anisotropy and brightness exceeding those of conventional chiral photon emitters by factors of 10 to 100. The helical structure of these filaments enables precise spectral tuning of the chiral emission, which can be modeled using electromagnetic principles and chirality metrics. Encapsulating nanocarbon filaments in refractive ceramics produces highly efficient, adjustable, and durable chiral emitters capable of functioning at extreme temperatures previously considered unattainable.","PeriodicalId":21678,"journal":{"name":"Science","volume":"22 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular RNA interacts with MAVS to promote antiviral signaling
IF 56.9 1区 综合性期刊
Science Pub Date : 2024-12-19 DOI: 10.1126/science.adl0429
Nandan S. Gokhale, Russell K. Sam, Kim Somfleth, Matthew G. Thompson, Daphnée M. Marciniak, Julian R. Smith, Emmanuelle Genoyer, Julie Eggenberger, Lan H. Chu, Moonhee Park, Steve Dvorkin, Andrew Oberst, Stacy M. Horner, Shao-En Ong, Michael Gale, Ram Savan
{"title":"Cellular RNA interacts with MAVS to promote antiviral signaling","authors":"Nandan S. Gokhale, Russell K. Sam, Kim Somfleth, Matthew G. Thompson, Daphnée M. Marciniak, Julian R. Smith, Emmanuelle Genoyer, Julie Eggenberger, Lan H. Chu, Moonhee Park, Steve Dvorkin, Andrew Oberst, Stacy M. Horner, Shao-En Ong, Michael Gale, Ram Savan","doi":"10.1126/science.adl0429","DOIUrl":"https://doi.org/10.1126/science.adl0429","url":null,"abstract":"Antiviral signaling downstream of RIG-I–like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein complex function can be modulated by RNA molecules that provide allosteric regulation or act as molecular guides or scaffolds. We hypothesized that RNA plays a role in organizing MAVS signaling platforms. We found that MAVS, through its central intrinsically disordered domain, directly interacted with the 3′ untranslated regions of cellular messenger RNAs. Elimination of RNA by ribonuclease treatment disrupted the MAVS signalosome, including RNA-modulated MAVS interactors that regulate RLR signaling and viral restriction, and inhibited phosphorylation of transcription factors that induce interferons. This work uncovered a function for cellular RNA in promoting signaling through MAVS and highlights generalizable principles of RNA regulatory control of immune signaling complexes.","PeriodicalId":21678,"journal":{"name":"Science","volume":"24 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A cellulose synthase–like protein governs the biosynthesis of Solanum alkaloids
IF 56.9 1区 综合性期刊
Science Pub Date : 2024-12-19 DOI: 10.1126/science.adq5721
Adam Jozwiak, Sayantan Panda, Ryota Akiyama, Ayano Yoneda, Naoyuki Umemoto, Kazuki Saito, Shuhei Yasumoto, Toshiya Muranaka, Sachin A. Gharat, Yana Kazachkova, Yonghui Dong, Shlomy Arava, Inna Goliand, Reinat Nevo, Ilana Rogachev, Sagit Meir, Masaharu Mizutani, Asaph Aharoni
{"title":"A cellulose synthase–like protein governs the biosynthesis of Solanum alkaloids","authors":"Adam Jozwiak, Sayantan Panda, Ryota Akiyama, Ayano Yoneda, Naoyuki Umemoto, Kazuki Saito, Shuhei Yasumoto, Toshiya Muranaka, Sachin A. Gharat, Yana Kazachkova, Yonghui Dong, Shlomy Arava, Inna Goliand, Reinat Nevo, Ilana Rogachev, Sagit Meir, Masaharu Mizutani, Asaph Aharoni","doi":"10.1126/science.adq5721","DOIUrl":"https://doi.org/10.1126/science.adq5721","url":null,"abstract":"Decades of research on the infamous antinutritional steroidal glycoalkaloids (SGAs) in Solanaceae plants have provided deep insights into their metabolism and roles. However, engineering SGAs in heterologous hosts has remained a challenge. We discovered that a protein evolved from the machinery involved in building plant cell walls is the crucial link in the biosynthesis of SGAs. We show that cellulose synthase–like M [GLYCOALKALOID METABOLISM15 (GAME15)] functions both as a cholesterol glucuronosyltransferase and a scaffold protein. Silencing <jats:italic>GAME15</jats:italic> depletes SGAs, which makes plants more vulnerable to pests. Our findings illuminate plant evolutionary adaptations that balance chemical defense and self-toxicity and open possibilities for producing steroidal compounds in heterologous systems for food, cosmetics, and pharmaceuticals.","PeriodicalId":21678,"journal":{"name":"Science","volume":"91 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142858477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Affinity maturation of antibody responses is mediated by differential plasma cell proliferation.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-19 DOI: 10.1126/science.adr6896
Andrew J MacLean, Lachlan P Deimel, Pengcheng Zhou, Mohamed A ElTanbouly, Julia Merkenschlager, Victor Ramos, Gabriela S Santos, Thomas Hägglöf, Christian T Mayer, Brianna Hernandez, Anna Gazumyan, Michel C Nussenzweig
{"title":"Affinity maturation of antibody responses is mediated by differential plasma cell proliferation.","authors":"Andrew J MacLean, Lachlan P Deimel, Pengcheng Zhou, Mohamed A ElTanbouly, Julia Merkenschlager, Victor Ramos, Gabriela S Santos, Thomas Hägglöf, Christian T Mayer, Brianna Hernandez, Anna Gazumyan, Michel C Nussenzweig","doi":"10.1126/science.adr6896","DOIUrl":"https://doi.org/10.1126/science.adr6896","url":null,"abstract":"<p><p>Increased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, producing antibodies with a wide spectrum of different affinities, are selected into the plasma cell (PC) pathway. How affinity-permissive selection enables PC affinity maturation remains unknown. We found that PC precursors (prePC) expressing high affinity antibodies received higher levels of T follicular helper (Tfh)-derived help and divided at higher rates than their lower affinity counterparts once they left the GC. Our findings indicated that differential cell division by selected prePCs accounts for how diverse precursors develop into a PC compartment that mediates serological affinity maturation.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":" ","pages":"eadr6896"},"PeriodicalIF":44.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of antigen-presenting cell-T cell interactions driving immune responses to food.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-19 DOI: 10.1126/science.ado5088
Maria C C Canesso, Tiago B R Castro, Sandra Nakandakari-Higa, Ainsley Lockhart, Julia Luehr, Juliana Bortolatto, Roham Parsa, Daria Esterházy, Mengze Lyu, Tian-Tian Liu, Kenneth M Murphy, Gregory F Sonnenberg, Bernardo S Reis, Gabriel D Victora, Daniel Mucida
{"title":"Identification of antigen-presenting cell-T cell interactions driving immune responses to food.","authors":"Maria C C Canesso, Tiago B R Castro, Sandra Nakandakari-Higa, Ainsley Lockhart, Julia Luehr, Juliana Bortolatto, Roham Parsa, Daria Esterházy, Mengze Lyu, Tian-Tian Liu, Kenneth M Murphy, Gregory F Sonnenberg, Bernardo S Reis, Gabriel D Victora, Daniel Mucida","doi":"10.1126/science.ado5088","DOIUrl":"https://doi.org/10.1126/science.ado5088","url":null,"abstract":"<p><p>The intestinal immune system must concomitantly tolerate food and commensals and protect against pathogens. Antigen-presenting cells (APCs) orchestrate these immune responses by presenting luminal antigens to CD4<sup>+</sup> T cells and inducing their differentiation into regulatory (pTreg) or inflammatory (Th) subsets. We used a proximity labeling method (LIPSTIC) to identify APCs that presented dietary antigens under tolerizing and inflammatory conditions and understand cellular mechanisms by which tolerance to food is induced and can be disrupted by infection. Helminth infections disrupted tolerance induction proportionally to the reduction in the ratio between tolerogenic APCs, including migratory dendritic cells (cDC1s) and Rorγt<sup>+</sup> APCs, and inflammatory APCs, that were primarily cDC2s. These inflammatory cDC2s expanded by helminth infection did not present dietary antigens, thus avoiding diet-specific Th2 responses.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":" ","pages":"eado5088"},"PeriodicalIF":44.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142865432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Science Journals.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-13 Epub Date: 2024-12-12 DOI: 10.1126/science.adv2103
Caroline Ash, Sacha Vignieri, Brent Grocholski, Keith T Smith, H Jesse Smith, Catherine Charneski, Leslie K Ferrarelli, L Bryan Ray, Michael A Funk, Phil Szuromi, Corinne Simonti, Stella M Hurtley, Mattia Maroso, Hannah M Isles
{"title":"In Science Journals.","authors":"Caroline Ash, Sacha Vignieri, Brent Grocholski, Keith T Smith, H Jesse Smith, Catherine Charneski, Leslie K Ferrarelli, L Bryan Ray, Michael A Funk, Phil Szuromi, Corinne Simonti, Stella M Hurtley, Mattia Maroso, Hannah M Isles","doi":"10.1126/science.adv2103","DOIUrl":"https://doi.org/10.1126/science.adv2103","url":null,"abstract":"<p><p>Highlights from the <i>Science</i> family of journals.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6727","pages":"1235-1237"},"PeriodicalIF":44.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More flow upstream and less flow downstream: The changing form and function of global rivers.
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-13 Epub Date: 2024-12-12 DOI: 10.1126/science.adl5728
Dongmei Feng, Colin J Gleason
{"title":"More flow upstream and less flow downstream: The changing form and function of global rivers.","authors":"Dongmei Feng, Colin J Gleason","doi":"10.1126/science.adl5728","DOIUrl":"https://doi.org/10.1126/science.adl5728","url":null,"abstract":"<p><p>We mapped daily streamflow from 1984 to 2018 in approximately 2.9 million rivers to assess recent changes to global river systems. We found that river outlets were dominated by significant decreases in flow, whereas headwaters were 1.7 times more likely to have significantly increased flow than decreased. These changes result in a significant upstream shift in streamflow experienced by about 29% of the global land surface. We found the most changes in the smallest steams in our study: increases in erosion potential (approximately 5% increase in stream power), flood frequency (approximately 42% increase in 100-year floods), and likely nutrient dynamics (altered seasonal flow regimes). We revealed these changes using \"detail at scale\" by mapping millions of individual rivers. Widely adopting this approach could reveal other changes to the hydrosphere.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6727","pages":"1305-1311"},"PeriodicalIF":44.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
China's 'dreamy' scientific drilling ship takes global command. 中国 "梦幻般 "的科学钻探船接受全球指挥。
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-13 Epub Date: 2024-12-12 DOI: 10.1126/science.adv2419
Dennis Normile
{"title":"China's 'dreamy' scientific drilling ship takes global command.","authors":"Dennis Normile","doi":"10.1126/science.adv2419","DOIUrl":"https://doi.org/10.1126/science.adv2419","url":null,"abstract":"<p><p>As U.S. leadership falters, <i>Meng Xiang</i> prepares for bold mission to retrieve rocks from Earth's mantle.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6727","pages":"1202-1203"},"PeriodicalIF":44.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flawed restoration plans on Tibetan plateau. 青藏高原的修复计划存在缺陷。
IF 44.7 1区 综合性期刊
Science Pub Date : 2024-12-13 Epub Date: 2024-12-12 DOI: 10.1126/science.ads3634
Yujie Niu, Johannes M H Knops, Limin Hua, Anke Jentsch
{"title":"Flawed restoration plans on Tibetan plateau.","authors":"Yujie Niu, Johannes M H Knops, Limin Hua, Anke Jentsch","doi":"10.1126/science.ads3634","DOIUrl":"https://doi.org/10.1126/science.ads3634","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6727","pages":"1233-1234"},"PeriodicalIF":44.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142819199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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