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Baby’s first surveillance technology 宝宝的第一个监控技术
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Veronica Barassi
{"title":"Baby’s first surveillance technology","authors":"Veronica Barassi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery research in physiologically maintained deceased. 研究发现死者的生理维持。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-05-01 DOI: 10.1126/science.adt3527
Douglas B Pet,Brendan Parent,Neel S Singhal,Claire D Clelland
{"title":"Discovery research in physiologically maintained deceased.","authors":"Douglas B Pet,Brendan Parent,Neel S Singhal,Claire D Clelland","doi":"10.1126/science.adt3527","DOIUrl":"https://doi.org/10.1126/science.adt3527","url":null,"abstract":"Expanded research opportunities in deceased humans require ongoing ethical inquiry.","PeriodicalId":21678,"journal":{"name":"Science","volume":"55 1","pages":"473-476"},"PeriodicalIF":56.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NextGen Voices: Pursuing Science Abroad 下一代之声：在国外追求科学
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
{"title":"NextGen Voices: Pursuing Science Abroad","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Other Journals 在其他期刊
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Ekeoma Uzogara, Madeleine Seale, Sarah H. Ross, Jack Huang, Sumin Jin, Brad Wible, Di Jiang
{"title":"In Other Journals","authors":"Ekeoma Uzogara, Madeleine Seale, Sarah H. Ross, Jack Huang, Sumin Jin, Brad Wible, Di Jiang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.ady6157","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting 定制植物糖缀合物用于肠道微生物介导的药物靶向
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-05-01 DOI: 10.1126/science.adk7633
Wei Jen Ma, Changqing Wang, Jagatheeswaran Kothandapani, Matthew Luzentales-Simpson, Susan C. Menzies, Danisa M. Bescucci, Máximo E. Lange, Alexander S. C. Fraser, Jenny F. Gusse, Kathaleen E. House, Paul E. Moote, Xiaohui Xing, Julie M. Grondin, Benjamin Wei‐Qiang Hui, Sandra T. Clarke, Tara G. Shelton, Natasha Haskey, Deanna L. Gibson, Eric C. Martens, D. Wade Abbott, G. Douglas Inglis, Laura M. Sly, Harry Brumer
{"title":"Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting","authors":"Wei Jen Ma, Changqing Wang, Jagatheeswaran Kothandapani, Matthew Luzentales-Simpson, Susan C. Menzies, Danisa M. Bescucci, Máximo E. Lange, Alexander S. C. Fraser, Jenny F. Gusse, Kathaleen E. House, Paul E. Moote, Xiaohui Xing, Julie M. Grondin, Benjamin Wei‐Qiang Hui, Sandra T. Clarke, Tara G. Shelton, Natasha Haskey, Deanna L. Gibson, Eric C. Martens, D. Wade Abbott, G. Douglas Inglis, Laura M. Sly, Harry Brumer","doi":"10.1126/science.adk7633","DOIUrl":"https://doi.org/10.1126/science.adk7633","url":null,"abstract":"The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a targeted drug delivery system based on bespoke glycoconjugates of a complex plant oligosaccharide called GlycoCaging. GlycoCaging of exemplar anti-inflammatory drugs enabled release of active molecules triggered by unique glycosidases of autochthonous gut bacteria. GlycoCaging ensured drug efficacy was potentiated, and off-target effects were eliminated in murine models of inflammatory bowel disease. Biochemical and metagenomic analyses of gut microbiota of individual humans confirmed the broad applicability of this strategy.","PeriodicalId":21678,"journal":{"name":"Science","volume":"35 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interphase cell morphology defines the mode, symmetry, and outcome of mitosis. 间期细胞形态决定有丝分裂的方式、对称性和结果。
IF 56.9 1区 综合性期刊
Science Pub Date : 2025-05-01 DOI: 10.1126/science.adu9628
Holly E Lovegrove,Georgia E Hulmes,Sabrina Ghadaouia,Christopher Revell,Marta Giralt-Pujol,Zain Alhashem,Andreia Pena,Damian D Nogare,Ellen Appleton,Guilherme Costa,Richard L Mort,Christoph Ballestrem,Gareth W Jones,Cerys S Manning,Ajay B Chitnis,Claudio A Franco,Claudia Linker,Katie Bentley,Shane P Herbert
{"title":"Interphase cell morphology defines the mode, symmetry, and outcome of mitosis.","authors":"Holly E Lovegrove,Georgia E Hulmes,Sabrina Ghadaouia,Christopher Revell,Marta Giralt-Pujol,Zain Alhashem,Andreia Pena,Damian D Nogare,Ellen Appleton,Guilherme Costa,Richard L Mort,Christoph Ballestrem,Gareth W Jones,Cerys S Manning,Ajay B Chitnis,Claudio A Franco,Claudia Linker,Katie Bentley,Shane P Herbert","doi":"10.1126/science.adu9628","DOIUrl":"https://doi.org/10.1126/science.adu9628","url":null,"abstract":"During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could concomitantly act as conserved instructive cues that trigger asymmetric division and direct core identity decisions underpinning tissue building. We performed single-cell morphometric analyses of endothelial and other mesenchymal-like cells. Distinct morphological changes switched cells to an \"isomorphic\" mode of division, which preserved pre-mitotic morphology throughout mitosis. In isomorphic divisions, interphase morphology appeared to provide a geometric code defining mitotic symmetry, fate determinant partitioning, and daughter state. Rab4-positive endosomes recognized this code, allowing them to respond to pre-mitotic morphology and segregate determinants accordingly. Thus, morphogenetic shape change sculpts tissue form while also generating cellular heterogeneity, thereby driving tissue assembly.","PeriodicalId":21678,"journal":{"name":"Science","volume":"13 1","pages":"eadu9628"},"PeriodicalIF":56.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stem cells as role models for reprogramming and repair 干细胞作为重编程和修复的榜样
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Magdalena Götz, Maria-Elena Torres-Padilla
{"title":"Stem cells as role models for reprogramming and repair","authors":"Magdalena Götz,&nbsp;Maria-Elena Torres-Padilla","doi":"","DOIUrl":"","url":null,"abstract":"<div >Stem cells are a promising source for cellular therapies across many diseases and tissues. Their inherent ability to differentiate into other cell types has been the focus of investigation over decades. This ability is currently being exploited for therapies using strategies to repair or replace damaged tissues and cells or to alleviate immune rejection. Exploring stem cell function has enabled direct reprogramming approaches, for example, through the production of induced pluripotent stem cells and the generation of tissue-specific stem cells. Understanding stem cell function has emerged as an important strategy for repopulating stem cell pools or generating differentiated cells for therapy. Here, we review general principles of mammalian stem cell biology and cellular reprogramming approaches and their use for current and future therapeutic purposes.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptation and gene flow are insufficient to rescue a montane plant under climate change 适应和基因流动不足以拯救气候变化下的山地植物
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Jill T. Anderson, Megan L. DeMarche, Derek A. Denney, Ian Breckheimer, James Santangelo, Susana M. Wadgymar
{"title":"Adaptation and gene flow are insufficient to rescue a montane plant under climate change","authors":"Jill T. Anderson,&nbsp;Megan L. DeMarche,&nbsp;Derek A. Denney,&nbsp;Ian Breckheimer,&nbsp;James Santangelo,&nbsp;Susana M. Wadgymar","doi":"","DOIUrl":"","url":null,"abstract":"<div >Climate change increasingly drives local population dynamics, shifts geographic distributions, and threatens persistence. Gene flow and rapid adaptation could rescue declining populations yet are seldom integrated into forecasts. We modeled eco-evolutionary dynamics under preindustrial, contemporary, and projected climates using up to 9 years of fitness data from 102,272 transplants (115 source populations) of <i>Boechera stricta</i> in five common gardens. Climate change endangers locally adapted populations and reduces genotypic variation in long-term population growth rate, suggesting limited adaptive potential. Upslope migration could stabilize high-elevation populations and preserve low-elevation ecotypes, but unassisted gene flow modeled with genomic data is too spatially restricted. Species distribution models failed to capture current dynamics and likely overestimate persistence under intermediate emissions scenarios, highlighting the importance of modeling evolutionary processes.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Searching for partners 寻找合作伙伴
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-05-01
Yuwei Zhong, Claude Desplan
{"title":"Searching for partners","authors":"Yuwei Zhong,&nbsp;Claude Desplan","doi":"","DOIUrl":"","url":null,"abstract":"<div >During human brain development, billions of neurons need to recognize their partners to form neuronal circuits. To explain this striking specificity, the chemoaffinity hypothesis proposes that neurons bear molecular identification tags (e.g., cell surface proteins) that distinguish them from one another and establish specific connections (<i>1</i>). Although this idea has been validated in some cases, given the limited number of cell surface proteins encoded by the genome, it is unlikely that such large numbers of neurons could rely solely on strict chemoaffinity to establish complicated neuronal networks (<i>2</i>). This problem might become insurmountable when the neurons have to find their targets in a three-dimensional (3D) environment. On page 538 of this issue, Lyu <i>et al</i>. (<i>3</i>) report that olfactory neurons in the fruit fly (<i>Drosophila</i>) solve this problem by reducing the dimensionality of the search path. These findings could help understand the wiring of the more complex mammalian brain.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6746","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A well-connected Earth: The science and conservation of organismal movement 一个紧密相连的地球：生物运动的科学与保护
IF 44.7 1区 综合性期刊
Science Pub Date : 2025-04-25 DOI: 10.1126/science.adn2225
Jedediah F. Brodie, Andrew Gonzalez, Jayasilan Mohd-Azlan, Cara R. Nelson, Gary Tabor, Divya Vasudev, Katherine A. Zeller, Robert J. Fletcher Jr.
{"title":"A well-connected Earth: The science and conservation of organismal movement","authors":"Jedediah F. Brodie,&nbsp;Andrew Gonzalez,&nbsp;Jayasilan Mohd-Azlan,&nbsp;Cara R. Nelson,&nbsp;Gary Tabor,&nbsp;Divya Vasudev,&nbsp;Katherine A. Zeller,&nbsp;Robert J. Fletcher Jr.","doi":"10.1126/science.adn2225","DOIUrl":"10.1126/science.adn2225","url":null,"abstract":"<div >Global biodiversity targets focus on landscape and seascape connectivity as a foundational component of biodiversity conservation, including networks of connected protected areas. Recent advances allow the measurement and prediction of organismal movements at multiple scales. We provide a definition of connectivity that links movement to persistence and ecological function. Connectivity science can guide planning for biodiversity, ecosystem services, ecological restoration, and climate adaptation. Ongoing climate change and land and sea use are closing the window of opportunity for connectivity conservation. A coordinated global effort is required to implement scientific knowledge and to monitor, map, protect, and restore areas that promote movement and maintain well-connected ecosystems for biodiversity in the long term.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"388 6745","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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