Applied Sciences-Basel最新文献

{"title":"Continuous Emotion Recognition Using EDA-Graphs: A Graph Signal Processing Approach for Affective Dimension Estimation.","authors":"Luis R Mercado-Diaz, Youngsun Kong, Josef Kundrát, Hugo F Posada-Quintero","doi":"10.3390/app16073240","DOIUrl":"10.3390/app16073240","url":null,"abstract":"<p><p>Emotion recognition from physiological signals has immense applications in healthcare and human-computer interaction. We developed an electrodermal activity (EDA)-graph signal processing pipeline that produces highly sensitive features for detecting the affective dimensions (arousal and valence) of emotions. Using the Continuously Annotated Signals of Emotion dataset, we compared our graph-based EDA features (EDA-graph) with traditional time- and frequency-domain EDA features and features derived from other signals (heart rate variability, pulse transit time, electromyography, skin temperature, and respiration) for detecting affective dimensions using machine learning regression models. The EDA-graph features showed superior performance in continuous affective dimension recognition compared to the most accurate state-of-the-art models, achieving RMSE values of 0.801 for arousal and 0.714 for valence. Furthermore, we used a variety of traditional and recently published datasets collected in laboratory and ambulatory settings to perform a comprehensive evaluation of the robust generalization capabilities of our approach across different emotional contexts. The models demonstrated exceptional performance in classifying emotional states across the datasets, achieving 98.2% accuracy in detecting positive, negative, and mixed emotions; 92.75% in discriminating between emotions (relaxed, amused, bored, scared, and neutral); and 86.54% in detecting stress vs. no stress. These results highlight the potential of a graph-based analysis of EDA in emotion recognition systems in different contexts, especially for real-world applications.</p>","PeriodicalId":48760,"journal":{"name":"Applied Sciences-Basel","volume":"16 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hexavalent Chromium Oropharyngeal Aspiration Induced Behavior Effects and Essential Metal Dyshomeostasis in Young Hartley Guinea Pigs.","authors":"Samuel T Vielee, Idoia Meaza, William J Buchanan, Spencer H Roof, Haiyan Lu, Sandra S Diven, Luping Guo, Jack Easley, J Calvin Kouokam, Jamie Lynn Wise, Aggie R Brownell, John Pierce Wise, John P Wise","doi":"10.3390/app16010059","DOIUrl":"https://doi.org/10.3390/app16010059","url":null,"abstract":"<p><p>Hexavalent chromium [Cr(VI)] is the toxic form of chromium often used in industry for its hardness, bright colors, and anticorrosive properties. Cr(VI) is a known human lung carcinogen, making its inhalation an occupational hazard. Growing evidence emphasizes the neurotoxic potential of Cr(VI), though it is not linked to brain cancers. Few studies consider neurotoxicity in chromate workers, reporting impaired olfactory discrimination and an increased risk of death from mental health disorders. A major factor limiting translation of most rodent Cr(VI) studies to human populations has to do with vitamin C, which can reduce the toxic Cr(VI) to non-toxic Cr(III). Rats and mice synthesize vitamin C and are likely more resistant to Cr(VI) than humans. Here, we considered Cr(VI) neurotoxicity in guinea pigs (<i>Cavia porcellus</i>), which do not endogenously synthesize vitamin C. We exposed Hartley guinea pigs (both sexes) to occupationally relevant concentrations of Cr(VI) via oropharyngeal aspiration weekly for 90 days. We observed behavioral effects in the open field assay, elevated plus maze, Y-maze, and novel object recognition test during weeks 9-12 of exposure. After euthanasia, we assessed Cr accumulation and essential metal dyshomeostasis in the hippocampus. We observed significantly increased hippocampal Cr accumulation in females, while males exhibited essential metal dyshomeostasis.</p>","PeriodicalId":48760,"journal":{"name":"Applied Sciences-Basel","volume":"16 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13099238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147786254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Comparison of Resin-Modified and Pure Calcium-Silicate Cements for Direct Pulp Capping.","authors":"Fatma Fenesha, Aonjittra Phanrungsuwan, Brian L Foster, Anibal Diogenes, Sarah B Peters","doi":"10.3390/app151910639","DOIUrl":"10.3390/app151910639","url":null,"abstract":"<p><strong>Introduction: </strong>Direct pulp capping (DPC) aims to preserve the vitality of the dental pulp by placing a protective biocompatible material over the exposed pulp tissue to facilitate healing. There are several calcium-silicate materials that have been designed to promote mineralization and the regulation of inflammation. These have strong potential for the repair and regeneration of dental pulp. Among them, Biodentine (BD) and EndoSequence RRM Putty (ES) have been found to promote in vitro and in vivo mineralization while minimizing some of the limitations of the first-generation calcium-silicate-based materials. Theracal-LC (TLC), a light-cured, resin-modified calcium-silicate material, is a newer product with potential to improve the clinical outcomes of DPC, but existing studies have reported conflicting findings regarding its biocompatibility and ability to support pulpal healing in direct contact with the pulp. A comprehensive assessment of the biocompatibility and pulpal protection provided by these three capping materials has not yet been performed.</p><p><strong>Aim: </strong>We aimed to quantify the inflammatory response, dentin bridge formation, and material adaptation following DPC using three calcium-silicate materials: ES, BD, and TLC.</p><p><strong>Materials and methods: </strong>DPC was performed on the maxillary first molar of C57BL/6 female mice. Maxilla were collected and processed at 1 and 21 days post-DPC. The early inflammatory response was measured 24 h post-procedure using confocal imaging of anti-Lys6G6C, which indicates the extent of neutrophil and monocyte infiltration. Reparative mineralized bridge formation was assessed at 21 days post-procedure using high-resolution micro-computed tomography (micro-CT) and histology. Lastly, the homogeneity of the capping materials was evaluated by quantifying voids in calcium-silicate restorations using micro-CT.</p><p><strong>Results: </strong>DPC using TLC induced less infiltration of Lys6G6C⁺ cells at 24 h than BD or ES. BD promoted higher volumes of tertiary dentin than TLC, but TLC and ES showed no significant differences in volume. No differences were observed in material adaptation and void spaces among the three capping materials.</p><p><strong>Conclusions: </strong>All three materials under investigation supported pulp healing and maintained marginal integrity. However, TLC induced a lower inflammatory response on day 1 and induced similar levels of tertiary dentin to ES. These observations challenge the common perception that resin-based capping materials are not suitable for direct pulp capping. Our findings underscore the need to balance biological responses with physical properties when selecting pulp capping materials to improve long-term clinical success.</p>","PeriodicalId":48760,"journal":{"name":"Applied Sciences-Basel","volume":"15 19","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12674660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145679191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee Loading Asymmetries During Descent and Ascent Phases of Squatting After ACL Reconstruction.","authors":"Manuel Angel Romero Padron, Alyx Jorgensen, David M Werner, Matthew Alan Tao, Elizabeth Wellsandt","doi":"10.3390/app15147780","DOIUrl":"10.3390/app15147780","url":null,"abstract":"<p><p>Asymmetries are common during squats following anterior cruciate ligament reconstruction (ACLR). This study examined interlimb loading differences between squat phases at 6 months post-ACLR. Thirty-five participants performed bodyweight squats at self-selected speed and were analyzed using 3D motion capture. Vertical ground reaction force impulse (vGRFi), external knee flexion moment impulse (KFMi) and hip-to-knee flexion moment impulse ratio (HKRi) were calculated, along with interlimb ratios (ILR). Squat phase durations were also recorded. Paired t-tests and ANCOVA (controlling for time) were used to compare biomechanical variables across squat phases. Greater asymmetry was observed during ascent for vGRFi ILR (<i>p</i> = 0.045), KFMi ILR (<i>p</i> < 0.001) and HKRi ILR (<i>p</i> = 0.006). The ascent phase was faster than descent (<i>p</i> = 0.036). After adjusting for time, phase-related differences in ILRs were no longer significant. These findings suggest that greater limb and knee-specific loading asymmetries occur during the ascent phase of squats but may be influenced by movement speed. Importantly, significant knee-specific loading asymmetries persisted regardless of squat phase. At 6 months post-ACLR, addressing neuromuscular control and movement speed during rehabilitation may help reduce biomechanical imbalances during closed kinetic chain exercises.</p>","PeriodicalId":48760,"journal":{"name":"Applied Sciences-Basel","volume":"15 14","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12539646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145349433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Muscle Activation Patterns and Muscle Synergies Pre- and Post-Balance Training in Older Adults.","authors":"J'niya Butler, Ambika Bhatta, Nicole Arnold, Younes El Hakour, Lara A Thompson","doi":"10.3390/app15116151","DOIUrl":"10.3390/app15116151","url":null,"abstract":"<p><p>In the aging population, imbalance leading to falls is of critical concern; thus, it is imperative to determine and quantify neuromuscular changes because of rehabilitative balance training. (1) Background: Previous studies that have examined changes in balance due to rehabilitative training placed a focus on clinical measures (i.e., behavioral, kinetic, and kinematic outputs); however, irregularities due to abnormalities of underlying neural origin were unrevealed by the aforementioned measures. (2) Methods: Examining muscle activity was used to determine strategies pre- and post-six weeks of balance training in twenty-three healthy older adults (69.5 ± 5.7 years old) and five survivors of stroke (66.4 ± 9.48 years old). Surface electromyographic (sEMG) signals were recorded from eight of the lower limb muscles while participants performed forward walking (FW), forward tandem walking (FT-W), backward walking (BW), and backward tandem walking (BT-W) tasks. The sEMG data were then conditioned and muscle synergies were extracted using non-negative matrix factorization (NNMF). (3) Results: It was observed that muscle synergies and activation patterns changed for pre- versus post-balance training in older adults (i.e., healthy individuals and those who had suffered from stroke). (4) Conclusions: From our findings, it was indicative that muscle activation and muscle synergies could be used to quantify and inform rehabilitative balance training in older adults.</p>","PeriodicalId":48760,"journal":{"name":"Applied Sciences-Basel","volume":"15 11","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the mHealth Nexus: A Semantic Analysis of mHealth Scholars' Research Propensities Following an Interdisciplinary Training Institute.","authors":"Junpeng Ren, Jinwen Luo, Yingshi Huang, Vivek Shetty, Minjeong Jeon","doi":"10.3390/app15116252","DOIUrl":"10.3390/app15116252","url":null,"abstract":"<p><p>Interdisciplinary research catalyzes innovation in mobile health (mHealth) by converging medical, technological, and social science expertise, driving critical advancements in this multifaceted field. Our longitudinal analysis evaluates how the NIH mHealth Training Institute (mHTI) program stimulates changes in research trajectories through a computational examination of 16,580 publications from 176 scholars (2015-2022 cohorts). We develop a hybrid analytical framework combining large language model (LLM) embeddings, Uniform Manifold Approximation and Projection (UMAP) dimensionality reduction, and Hierarchical Density-Based Spatial Clustering of Applications with Noise (HDBSCAN) clustering to construct a semantic research landscape containing 329 micro-topics aggregated into 14 domains. GPT-4o-assisted labeling identified mHealth-related publications occupying central positions in the semantic space, functioning as conceptual bridges between disciplinary clusters such as clinical medicine, public health, and technological innovation. Kernel density estimation of research migration patterns revealed 63.8% of scholars visibly shifted their publication focus toward mHealth-dense regions within three years post-training. The reorientation demonstrates mHTI's effectiveness in fostering interdisciplinary intellect with sustained engagement, evidenced by growth in mHealth-aligned publications from the mHTI scholars. Our methodology advances science of team science research by demonstrating how LLM-enhanced topic modeling coupled with spatial probability analysis can track knowledge evolution in interdisciplinary fields. The findings provide empirical validation for structured training programs' capacity to stimulate convergent research, while offering a scalable framework for evaluating inter/transdisciplinary initiatives. The dual contribution bridges methodological innovation in natural language processing with practical insights for cultivating next-generation mHealth scholarship.</p>","PeriodicalId":48760,"journal":{"name":"Applied Sciences-Basel","volume":"15 11","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12724682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145828496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Virtual Reality and Robotic Training Effects on Balance Ability and Confidence in Older Adults.","authors":"Oluwasola Okhuoya, Lara A Thompson","doi":"10.3390/app15115909","DOIUrl":"10.3390/app15115909","url":null,"abstract":"<p><p>Falls are the leading cause of injury and mortality among older adults-one in four individuals 65 years old and above experiences falls. Thus, balance training interventions that improve balance ability and reduce the risk of falls are of critical importance. Through two complementary interventions, our research sought to determine the effects of Virtual Reality (VR) compared to Robotic-Assisted Balance Training (RABT) on balance ability and balance confidence in older adults. The VR intervention utilized Oculus headsets to create immersive balance exercises, while the RABT employed a multidirectional overground robotic system (NaviGAITor). Participants (aged 60-85 years old) underwent a 6-week training protocol consisting of two 30 min sessions per week. Balance ability was quantified using center of pressure (COP) parameters and the Balance Error Scoring System (BESS), while balance confidence was measured using the Activities-Specific Balance Confidence (ABC) scale. Results indicated no statistically significant differences between the training methods. However, the RABT group showed trends toward enhanced balance performance, with observed decreases in mediolateral (ML) maximum displacement during wide stance conditions and reductions in BESS errors on both firm and foam surfaces. The VR group demonstrated significant changes in ML RMS values during tandem stance (<i>p</i> = 0.045) and improved participants' relationship with perceived and actual balance ability (increased correlation between BESS errors and ABC scores from R² = 0.00 pre-training to R² = 0.65 post-training). Balance confidence did not significantly increase in either group. These findings suggest that while RABT may trend toward improvements in objective balance parameters, VR training appears to enhance participants' perceptual accuracy of their balance capabilities.</p>","PeriodicalId":48760,"journal":{"name":"Applied Sciences-Basel","volume":"15 11","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147844490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in Bioactive Materials for Dental Pulp Vitality Preservation in Children and Adolescents.","authors":"Purva K Desai, Shreya M Hiwalkar, Hyun-Joo Kim, Jonghyun Shin, Hyo-Seol Lee, Ho-Wook Jun, Kyounga Cheon","doi":"10.3390/app15094699","DOIUrl":"10.3390/app15094699","url":null,"abstract":"<p><p>Preserving dental pulp vitality is crucial in pediatric and adolescent dentistry to promote long-term oral health and reduce the need for invasive procedures. Vital pulp therapy (VPT) enhances pulp healing and dentin formation through advanced pulp capping materials. While calcium hydroxide-based materials laid the foundation for VPT, calcium silicate-based materials like mineral trioxide aggregate, Biodentine, and TheraCal offer superior biocompatibility and sealing properties. Recent advancements focus on regenerative strategies that enhance biocompatibility, antibacterial efficacy, and anti-inflammatory effects. Tissue engineering approaches, including stem cells, growth factors, and peptide-based scaffolds, are being explored to improve pulp regeneration and long-term treatment success. This review highlights recent developments in VPT for pediatric and adolescent patients, emphasizing minimally invasive techniques, clinical challenges, and the potential of emerging biomaterials. Continued research into biomaterial efficacy and regenerative capabilities holds promise for advancing VPT, ensuring more effective and biologically driven treatment strategies for young patients.</p>","PeriodicalId":48760,"journal":{"name":"Applied Sciences-Basel","volume":"15 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12692128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145745315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Feasibility and User Experience of a Program of Progressive Cued Activity to Promote Functional Upper Limb Activity in the Inpatient Rehabilitation Setting with Follow-Up at Home.","authors":"Kimberly Bassindale, Sarah Golus, Jake Horder, Maureen Winkoski, Meghann Sytsma, Whitney A Morelli, Maura Casadio, John McGuire, Robert A Scheidt","doi":"10.3390/app15063010","DOIUrl":"10.3390/app15063010","url":null,"abstract":"<p><p>Although upper limb impairment is one of the most common deficits post-stroke and contributes substantially to diminished functional independence, many survivors receive low dosages of upper limb task training in the inpatient setting. This study evaluates the feasibility and user experience of a progressive-challenge cued activity program, delivered via wearable technology, to promote upper limb activity in an inpatient rehabilitation facility (IRF) post-stroke. Participants (<i>N</i> = 30) wore our wearable system <i>Souvenir</i>, which provided vibrotactile cues to prompt activity in the more-involved arm during idle time. Compliance with the program was high (94% in the IRF), and the system successfully prompted increased activity, as evidenced by significantly higher post-cue response rates compared to pre-cue activity rates (mean difference = 35.1%, <i>t</i>(28) = 9.398, <i>p</i> < 0.001). User experience was positive, with participants reporting high usability, satisfaction, and motivation. Follow-up data collected in unstructured home settings (<i>n</i> = 23) demonstrated continued high compliance (96%) and favorable user experience. These findings suggest that <i>Souvenir</i> and its cued activity program can effectively convert idle time into therapeutic activity while minimizing caregiver burden. Future research should focus on enhancing user engagement and evaluating the clinical efficacy of this approach in improving functional outcomes post-stroke.</p>","PeriodicalId":48760,"journal":{"name":"Applied Sciences-Basel","volume":"15 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144734358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Subglottic Stenosis Severity on Vocal Fold Vibration and Voice Production in Realistic Laryngeal and Airway Geometries Using Fluid-Structure-Acoustics Interaction Simulation.","authors":"Dariush Bodaghi, Qian Xue, Scott Thomson, Xudong Zheng","doi":"10.3390/app15031168","DOIUrl":"10.3390/app15031168","url":null,"abstract":"<p><p>This study investigates the impact of subglottic stenosis (SGS) on voice production using a subject-specific laryngeal and airway model. Direct numerical simulations of fluid-structure-acoustic interaction were employed to analyze glottal flow dynamics, vocal fold vibration, and acoustics under realistic conditions. The model accurately captured key physiological parameters, including the glottal flow rate, vocal fold vibration patterns, and the first four formant frequencies. Simulations of varying SGS severity revealed that up to 75% stenosis, vocal function remains largely unaffected. However, at 90% severity, significant changes in glottal flow and acoustics were observed, with vocal fold vibration remaining stable. At 96%, severe reductions in glottal flow and acoustics, along with marked changes in vocal fold dynamics, were detected. Flow resistance, the ratio of glottal to stenosis area, and pressure drop across the vocal folds were identified as critical factors influencing these changes. The use of anatomically realistic airway and vocal fold geometries revealed that while anatomical variations minimally affect voice production at lower stenosis grades, they become critical at severe stenosis levels (>90%), particularly in capturing distinct anterior-posterior opening patterns and focused jet effects that alter glottal dynamics. These findings suggest that while simplified models suffice for analyzing mild to moderate stenosis, patient-specific geometric details are essential for accurate prediction of vocal fold dynamics in severe cases.</p>","PeriodicalId":48760,"journal":{"name":"Applied Sciences-Basel","volume":"15 3","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}