Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献

Statistical and mechanical analysis of multi-pseudopodial locomotion in a testate amoeba, Arcella sp. 无足变形虫多假足运动的统计和力学分析。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-09 Epub Date: 2025-11-19 DOI: 10.2183/pjab.102.001

Genta Matsumoto, Atsushi Taniguchi, Mami Nomura, Satoshi Shimano, Jean-Paul Rieu, Katsuhiko Sato, Toshiyuki Nakagaki, Yukinori Nishigami

{"title":"Statistical and mechanical analysis of multi-pseudopodial locomotion in a testate amoeba, Arcella sp.","authors":"Genta Matsumoto, Atsushi Taniguchi, Mami Nomura, Satoshi Shimano, Jean-Paul Rieu, Katsuhiko Sato, Toshiyuki Nakagaki, Yukinori Nishigami","doi":"10.2183/pjab.102.001","DOIUrl":"10.2183/pjab.102.001","url":null,"abstract":"Adherent eukaryotic cells typically exhibit amoeboid locomotion through actin polymerization and bleb-driven mechanisms. However, testate amoebae, which enclose their bodies within a shell, exhibit variation in these locomotion types. This study focused on Arcella, a representative testate amoeba that pulls its shell using multiple pseudopods extending from a single aperture on the ventral side. Arcella is found in peatlands and freshwater, where it adapts its movement to various substrates. We characterized its movement on glass as well as hard, and soft gel substrates through detailed observation. The results indicated a higher randomness in motion on the soft gel, which was influenced by the pseudopodial elongation direction. Additionally, we evaluated the relationship between movement direction and traction stress. The dipole moment of the traction stress field determined the axis of motion, whereas quadrupole moments were correlated with forward and lateral movements. Although some relationships between multipole moments and velocity were shared with other cells, Arcella exhibited unique characteristics in its movement mechanism, which likely occurred due to its use of multiple pseudopods alongside its shell.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":" ","pages":"57-70"},"PeriodicalIF":4.6,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative sequence analysis of the mouse pseudoautosomal region from three inbred strains reveals it to be the most rapidly evolving 'chromosome'. 从三个近交系的小鼠假常染色体区域的比较序列分析显示，它是进化最快的“染色体”。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.007

Takaoki Kasahara, Kazuyuki Mekada, Kuniya Abe, Alan Ashworth, Tadafumi Kato

{"title":"Comparative sequence analysis of the mouse pseudoautosomal region from three inbred strains reveals it to be the most rapidly evolving 'chromosome'.","authors":"Takaoki Kasahara, Kazuyuki Mekada, Kuniya Abe, Alan Ashworth, Tadafumi Kato","doi":"10.2183/pjab.102.007","DOIUrl":"10.2183/pjab.102.007","url":null,"abstract":"The pseudoautosomal region (PAR) of mammalian sex chromosomes is a small region of sequence identity shared by the X and Y chromosomes that allows pairing, crossover, recombination, and proper segregation of sex chromosomes. Although the mouse PAR sequence was largely a mystery, we have recently obtained the complete PAR sequences of the C57BL/6J and CAST/EiJ strains. Here, we report the complete PAR sequence of a Japanese wild mouse-derived strain, MSM/Ms, and compare the PARs of the three strains. There are considerable differences in the size of PARs between strains (MSM/Ms PAR is only about 20% the length of C57BL/6J PAR) and numerous amino acid substitution variants were found in the PAR genes. High GC-content exons and short introns are common features of the PAR genes and are likely a consequence of maintaining the functions of the encoded proteins during rapid evolution of the mouse PAR, whose recombination frequency in male meiosis is ∼100 times higher than the autosomal average.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 3","pages":"114-128"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding and controlling pandemic influenza. 了解和控制大流行性流感。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.010

Hiroshi Kida, Toshihiro Ito, Lorena E Brown

引用次数: 0

BRD9 at the crossroads of splicing, chromatin remodeling, and hematopoiesis. BRD9在剪接、染色质重塑和造血的十字路口。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.005

Takaya Yamasaki, Koutarou Nishimura, Daichi Inoue

{"title":"BRD9 at the crossroads of splicing, chromatin remodeling, and hematopoiesis.","authors":"Takaya Yamasaki, Koutarou Nishimura, Daichi Inoue","doi":"10.2183/pjab.102.005","DOIUrl":"10.2183/pjab.102.005","url":null,"abstract":"BAF complexes are ATP-dependent chromatin remodelers that govern gene expression and cellular identity. The non-canonical BAF (ncBAF) complex, with BRD9 as its signature component, orchestrates chromatin remodeling essential for balanced hematopoiesis. BRD9 loss disrupts enhancer-promoter interactions and CTCF-mediated chromatin architecture, causing myeloid skewing, impaired lymphoid differentiation, and diminished hematopoietic stem cell (HSC) fitness-phenotypes recapitulating physiological aging. This mechanism underlies aging-related pathologies such as myelodysplastic syndromes (MDS), in which spliceosomal mutations in SF3B1 trigger aberrant BRD9 splicing and destabilize its mRNA. Remarkably, BRD9 exhibits context-dependent functions: its depletion consistently promotes differentiation and apoptosis in myeloid leukemias, contrasting its differential roles in myeloid differentiation in adult versus fetal hematopoiesis. Thus, BRD9 mechanistically links spliceosomal dysfunction to chromatin dysregulation, bridging aging-associated disease and malignant transformation through context-dependent roles. Among the diverse assemblies of BAF family, these findings position the BRD9-ncBAF axis as both a critical determinant of hematopoietic fate decisions and a promising therapeutic target in hematologic malignancies.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 2","pages":"71-81"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13000111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spider silk-based structural proteins as tough, biodegradable, and sustainable polymers. 蜘蛛丝结构蛋白坚韧，可生物降解，可持续聚合物。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.003

Keiji Numata

引用次数: 0

Highly polymorphic copy number variation in a segmental duplication in the mouse pseudoautosomal region even within inbred laboratory strains. 高多态性拷贝数变异在小鼠假常染色体区域的片段复制甚至在近交实验室菌株。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.009

Takaoki Kasahara

引用次数: 0

Bioorganic studies on the nyctinastic leaf-movement of plants. 植物叶片动态运动的生物有机研究。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.002

Minoru Ueda, Yuki Muraoka

引用次数: 0

Molecular pathogenesis and evolving treatment landscape of extranodal NK/T-cell lymphoma. 结外NK/ t细胞淋巴瘤的分子发病机制及治疗进展。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.008

Junji Koya, Keisuke Kataoka

{"title":"Molecular pathogenesis and evolving treatment landscape of extranodal NK/T-cell lymphoma.","authors":"Junji Koya, Keisuke Kataoka","doi":"10.2183/pjab.102.008","DOIUrl":"10.2183/pjab.102.008","url":null,"abstract":"Extranodal NK/T-cell lymphoma (ENKTL) is a rare, aggressive Epstein-Barr virus (EBV)-associated malignancy. The 5th edition of the WHO classification refined their nomenclature by removing \"nasal type\" and introducing related entities to reflect updated biological insights. This review synthesizes recent advances in epidemiology and molecular pathogenesis in ENKTL, highlighting recurrent driver gene alterations, particularly frequent mutations in X-linked genes such as DDX3X and MSN, alongside TP53 mutations and PD-L1 structural variations that facilitate immune evasion. We also discuss novel mouse models that replicate the ENKTL niche, revealing how Trp53 loss and the EBV oncoprotein LMP1 synergistically remodel the tumor microenvironment to promote lymphomagenesis. Therapeutically, while L-asparaginase-based regimens including SMILE and P-GemOx remain the standard of care, emerging immune checkpoint inhibitors have demonstrated encouraging efficacy, particularly in combination with chemotherapy. This review provides an integrated perspective on the evolving landscape of diagnosis, disease biology, and translational treatment strategies for NK/T-cell lymphoproliferative disorders.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 3","pages":"105-113"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Japanese gut microbiome: ecology, uniqueness, and impact on health and disease. 日本人的肠道微生物群：生态学、独特性以及对健康和疾病的影响。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.006

Suguru Nishijima, Masahira Hattori, Naoyoshi Nagata

引用次数: 0

Multimodal flexible sensor system toward telediagnosis. 面向远程诊断的多模态柔性传感器系统。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.004

Do Hoon Lee, Kuniharu Takei

{"title":"Multimodal flexible sensor system toward telediagnosis.","authors":"Do Hoon Lee, Kuniharu Takei","doi":"10.2183/pjab.102.004","DOIUrl":"10.2183/pjab.102.004","url":null,"abstract":"Advancements in living standards, medical technologies, and nutrition have contributed to the global increase in life expectancy. However, the widening gap between life expectancy and healthy life expectancy indicates that a growing population requires ongoing medical care and hospitalization. The development of a home-use telediagnostic system is a promising solution for improving the quality of life for patients and healthcare providers to extend a healthy lifespan and reduce the burden on clinicians. Such a system also holds the potential for rapid health assessments during emergency situations, where timely triage is critical. This study reviews recent progress in noninvasive, multimodal sensor patches capable of continuously monitoring vital signs and biomarkers via the skin. Furthermore, we explore the integration of machine learning for real-time, on-device data analysis as an edge system, enabling autonomous health feedback without reliance on the Internet. Although several technical challenges remain before practical implementation, these innovations may pave the way for a paradigm shift in conventional medical care.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 1","pages":"18-39"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145960041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0