Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献

Exocarpium Citri Grandis oil relieves depressive-like behaviors via neurotransmitter and inflammatory pathway modulation. 柑桔精油通过神经递质和炎症通路调节来缓解抑郁样行为。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-10-09 Epub Date: 2026-06-10 DOI: 10.2183/pjab.102.018

Kang Li, Yijing Zhong, Muhammad Waqas, Hongming Yin, Zhile Kong, Zunnan Huang, Yi Qi

{"title":"Exocarpium Citri Grandis oil relieves depressive-like behaviors via neurotransmitter and inflammatory pathway modulation.","authors":"Kang Li, Yijing Zhong, Muhammad Waqas, Hongming Yin, Zhile Kong, Zunnan Huang, Yi Qi","doi":"10.2183/pjab.102.018","DOIUrl":"10.2183/pjab.102.018","url":null,"abstract":"Depression remains a global mental health challenge, with current treatments often limited by therapeutic instability, side effects, and patient adherence. This study investigated Exocarpium Citri Grandis essential oil (ECG oil) as a natural antidepressant. Extraction was optimized using Plackett-Burman Design-Response Surface Methodology (PBD-RSM), achieving a 15.224% yield. Gas chromatography-mass spectrometry (GC-MS) analysis identified D-limonene, α/β-pinene, and γ-terpinene as major active components. In vivo, both oral and nebulized ECG oil significantly alleviated depressive-like behaviors in a zebrafish larval model and chronic unpredictable mild stress (CUMS) mice (evidenced by tail suspension, open field, forced swim, and sucrose preference tests). Biochemically, ECG oil enhanced neurotransmitter activity and reduced monoamine oxidase A (MAOA) levels. Furthermore, network pharmacology coupled with molecular docking and experimental validation (qRT-PCR and Western blot) revealed that ECG oil exerts its efficacy by modulating key targets, including OXT, ESR1, PTGS2, and LEP. Conclusively, ECG oil represents a promising natural therapeutic for depression by regulating neurotransmitter and neuroinflammatory pathways.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":" ","pages":"314-334"},"PeriodicalIF":2.9,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topology optimization for link mechanism synthesis based on multi-layered generalized continuum model. 基于多层广义连续体模型的连杆机构综合拓扑优化。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-10-09 Epub Date: 2026-07-16 DOI: 10.2183/pjab.102.020

Yurika Sayo, Takayuki Yamada

引用次数: 0

Production of functional sperm from the red seabream (Pagrus major) ovotestis on a xenogeneic zebrafish Sertoli cell line in culture. 异种斑马鱼Sertoli细胞系培养中红鲷卵睾丸产生功能精子的研究。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-10-08 DOI: 10.2183/pjab.102.025

Noriyoshi Sakai, Youhei Washio, Keitaro Kato, Masato Kinoshita

{"title":"Production of functional sperm from the red seabream (Pagrus major) ovotestis on a xenogeneic zebrafish Sertoli cell line in culture.","authors":"Noriyoshi Sakai, Youhei Washio, Keitaro Kato, Masato Kinoshita","doi":"10.2183/pjab.102.025","DOIUrl":"https://doi.org/10.2183/pjab.102.025","url":null,"abstract":"In vitro culture of germ cells has the potential to accelerate gametogenesis because it is independent of the body's endocrine control. However, the need to determine culture conditions for each species has limited the application of this method for many species. Here, we report the establishment of a culture system for germ cells from the ovotestes of red seabream to differentiate into functional sperm, as well as the use of a zebrafish Sertoli cell line as feeder cells for seabream germ cells. We first determined the culture conditions for red seabream germ cells based on a zebrafish spermatogonia culture system. Spermatogenesis was successfully induced by replacing cyprinid-derived body fluid components with red seabream serum and by using seabream collagen-coated dishes. Functional sperm were obtained from spermatogonia-enriched ovotestis dissociates after 28 days of culture. Furthermore, when red seabream germ cells were cultured on the zebrafish Sertoli cell line, they adhered to the feeder cells and differentiated into functional sperm. Given the phylogenetic distance between seabream and zebrafish, these results suggest that germ cell culture may be widely applied to teleost fish through modification of body fluid factors and the use of xenogeneic zebrafish Sertoli cells as feeder cells.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Historical development of psycho-oncology in Japan: From clinical observation to national cancer policy. 日本心理肿瘤学的历史发展：从临床观察到国家癌症政策。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-10-08 DOI: 10.2183/pjab.102.026

Yosuke Uchitomi, Maiko Fujimori, Tatsuo Akechi

{"title":"Historical development of psycho-oncology in Japan: From clinical observation to national cancer policy.","authors":"Yosuke Uchitomi, Maiko Fujimori, Tatsuo Akechi","doi":"10.2183/pjab.102.026","DOIUrl":"https://doi.org/10.2183/pjab.102.026","url":null,"abstract":"Psycho-oncology has emerged as a multidisciplinary field addressing the psychological, social, and behavioral dimensions of cancer. Although its development has been well documented in Western countries, Japan has followed a distinct trajectory shaped by its cultural context, healthcare system, and national cancer policy. Building on early clinical observations, epidemiological studies clarified the prevalence, determinants, and longitudinal course of psychological distress across the cancer trajectory. Communication-preference research subsequently informed the development of the SHARE communication framework, while patient-directed communication support using Question Prompt Lists promoted shared decision-making. Research on survivorship, end-of-life care, and supportive care further expanded psycho-oncology from the management of psychiatric disorders to comprehensive supportive cancer care. These scientific advances became increasingly integrated into national cancer policy following enactment of the Cancer Control Act. Overall, these developments illustrate how psycho-oncology in Japan evolved from clinical observation to evidence-based practice and ultimately became integrated into routine cancer care through implementation science and national cancer policy. Despite these advances, important challenges remain, including disparities in access to psychosocial care, a limited specialist workforce, and variability in the quality of patient-clinician communication, underscoring the need for continued implementation and quality improvement.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149128390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statistical and mechanical analysis of multi-pseudopodial locomotion in a testate amoeba, Arcella sp. 无足变形虫多假足运动的统计和力学分析。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-09 Epub Date: 2025-11-19 DOI: 10.2183/pjab.102.001

Genta Matsumoto, Atsushi Taniguchi, Mami Nomura, Satoshi Shimano, Jean-Paul Rieu, Katsuhiko Sato, Toshiyuki Nakagaki, Yukinori Nishigami

{"title":"Statistical and mechanical analysis of multi-pseudopodial locomotion in a testate amoeba, Arcella sp.","authors":"Genta Matsumoto, Atsushi Taniguchi, Mami Nomura, Satoshi Shimano, Jean-Paul Rieu, Katsuhiko Sato, Toshiyuki Nakagaki, Yukinori Nishigami","doi":"10.2183/pjab.102.001","DOIUrl":"10.2183/pjab.102.001","url":null,"abstract":"Adherent eukaryotic cells typically exhibit amoeboid locomotion through actin polymerization and bleb-driven mechanisms. However, testate amoebae, which enclose their bodies within a shell, exhibit variation in these locomotion types. This study focused on Arcella, a representative testate amoeba that pulls its shell using multiple pseudopods extending from a single aperture on the ventral side. Arcella is found in peatlands and freshwater, where it adapts its movement to various substrates. We characterized its movement on glass as well as hard, and soft gel substrates through detailed observation. The results indicated a higher randomness in motion on the soft gel, which was influenced by the pseudopodial elongation direction. Additionally, we evaluated the relationship between movement direction and traction stress. The dipole moment of the traction stress field determined the axis of motion, whereas quadrupole moments were correlated with forward and lateral movements. Although some relationships between multipole moments and velocity were shared with other cells, Arcella exhibited unique characteristics in its movement mechanism, which likely occurred due to its use of multiple pseudopods alongside its shell.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":" ","pages":"57-70"},"PeriodicalIF":2.9,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative sequence analysis of the mouse pseudoautosomal region from three inbred strains reveals it to be the most rapidly evolving 'chromosome'. 从三个近交系的小鼠假常染色体区域的比较序列分析显示，它是进化最快的“染色体”。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.007

Takaoki Kasahara, Kazuyuki Mekada, Kuniya Abe, Alan Ashworth, Tadafumi Kato

{"title":"Comparative sequence analysis of the mouse pseudoautosomal region from three inbred strains reveals it to be the most rapidly evolving 'chromosome'.","authors":"Takaoki Kasahara, Kazuyuki Mekada, Kuniya Abe, Alan Ashworth, Tadafumi Kato","doi":"10.2183/pjab.102.007","DOIUrl":"10.2183/pjab.102.007","url":null,"abstract":"The pseudoautosomal region (PAR) of mammalian sex chromosomes is a small region of sequence identity shared by the X and Y chromosomes that allows pairing, crossover, recombination, and proper segregation of sex chromosomes. Although the mouse PAR sequence was largely a mystery, we have recently obtained the complete PAR sequences of the C57BL/6J and CAST/EiJ strains. Here, we report the complete PAR sequence of a Japanese wild mouse-derived strain, MSM/Ms, and compare the PARs of the three strains. There are considerable differences in the size of PARs between strains (MSM/Ms PAR is only about 20% the length of C57BL/6J PAR) and numerous amino acid substitution variants were found in the PAR genes. High GC-content exons and short introns are common features of the PAR genes and are likely a consequence of maintaining the functions of the encoded proteins during rapid evolution of the mouse PAR, whose recombination frequency in male meiosis is ∼100 times higher than the autosomal average.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 3","pages":"114-128"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147434976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design principles for hydrogen-embrittlement-resistant FCC alloys: solution-treated steels and Ni-Cr-Fe alloys -An overview. 抗氢脆FCC合金的设计原则：固溶处理钢和Ni-Cr-Fe合金概述

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.014

Motomichi Koyama, Kota Tomatsu, Tomohiko Ohmura

{"title":"Design principles for hydrogen-embrittlement-resistant FCC alloys: solution-treated steels and Ni-Cr-Fe alloys -An overview.","authors":"Motomichi Koyama, Kota Tomatsu, Tomohiko Ohmura","doi":"10.2183/pjab.102.014","DOIUrl":"10.2183/pjab.102.014","url":null,"abstract":"In this study, we reviewed the factors affecting the hydrogen embrittlement susceptibility of solution-treated austenitic steels and Ni-Cr (-Fe) alloys with face-centered cubic (FCC) structures. These alloy systems exhibit many microstructural similarities; however, when hydrogen is introduced, they display numerous differences. These differences can be explained in terms of FCC phase stability, dislocation slip planarity, deformation twinnability, and grain boundary strength. Although these factors have been clarified in various studies, they are not comprehensively understood across a wide range of chemical compositions. Recent studies have measured numerous hydrogen embrittlement data in FCC alloys and characterized the elemental effects on relevant metallurgical data, such as phase stability, grain boundary strength, stacking fault energy, and atomistic interactions. Therefore, we summarized and correlated the data to establish a comprehensive alloy design strategy for hydrogen-resistant steels and Ni alloys. Furthermore, the effect of grain refinement and related insights are also discussed toward developing high-strength hydrogen-resistant FCC alloys.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 6","pages":"179-199"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in systemic therapy for biliary tract cancer: Evidence from Japan and recommendations in guidelines. 胆道癌全身治疗的最新进展：来自日本的证据和指南中的建议。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.022

Takuji Okusaka, Junji Furuse, Masaru Konishi, Masayuki Ohtsuka

{"title":"Recent advances in systemic therapy for biliary tract cancer: Evidence from Japan and recommendations in guidelines.","authors":"Takuji Okusaka, Junji Furuse, Masaru Konishi, Masayuki Ohtsuka","doi":"10.2183/pjab.102.022","DOIUrl":"https://doi.org/10.2183/pjab.102.022","url":null,"abstract":"Systemic therapy for biliary tract cancer (BTC) has evolved substantially over the past two decades. Gemcitabine plus cisplatin was established as the global standard first-line regimen, followed by further optimization through alternative doublets, intensified triplet chemotherapy, and the recent introduction of immune checkpoint inhibitor-based combinations. In Japan, pivotal clinical trials have played a valuable role in refining treatment strategies, including the establishment of gemcitabine plus S-1, gemcitabine, cisplatin, plus S-1, and adjuvant S-1 after curative resection. Beyond cytotoxic chemotherapy, molecular targeted therapy and tumor-agnostic approaches have expanded treatment options for selected patients in the second-line and later-line settings. Actionable alterations such as FGFR2 fusions, IDH1 mutations, HER2 amplification, microsatellite instability-high status, and other rare genomic events enable precision medicine approaches with meaningful clinical benefit. Despite these advances, prognosis remains poor for many patients with BTC. Ongoing efforts to optimize treatment sequencing, refine perioperative strategies, and integrate comprehensive molecular profiling are expected to further improve outcomes. Continued generation of high-quality clinical evidence and international collaboration will be essential to advance the management of BTC.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 8","pages":"303-313"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding and controlling pandemic influenza. 了解和控制大流行性流感。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.010

Hiroshi Kida, Toshihiro Ito, Lorena E Brown

{"title":"Understanding and controlling pandemic influenza.","authors":"Hiroshi Kida, Toshihiro Ito, Lorena E Brown","doi":"10.2183/pjab.102.010","DOIUrl":"10.2183/pjab.102.010","url":null,"abstract":"Influenza A virus infection is a zoonosis. The natural reservoirs of the viruses are migratory water birds, particularly ducks. Through a process of reassortment of the genomes of avian and human influenza viruses, novel virus strains may arise to which humans are not immune. Such a virus can spread rapidly throughout populations as a pandemic, usually with serious consequences. Effective preparedness for future influenza pandemics depends on robust global surveillance of avian, swine, mammalian, and human influenza and continuous updating of our Library of Influenza Viruses from these hosts to aid diagnosis and vaccine production. Enhancing and refining strategies for controlling seasonal influenza, including the development of more potent vaccines and therapeutic medicines, that can be seamlessly implemented when a new influenza virus emerges is crucial. This review, which draws on more than half a century of our research on the ecology of influenza viruses, describes how pandemic influenza viruses arise and outlines strategies for preparedness against future pandemics.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 4","pages":"137-155"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13199642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147676062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond gene ends: The expanding roles of transcription termination in genome stability and cellular homeostasis. 超越基因末端：转录终止在基因组稳定性和细胞稳态中的扩展作用。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.023

Chihiro Nakayama, Takayuki Nojima

{"title":"Beyond gene ends: The expanding roles of transcription termination in genome stability and cellular homeostasis.","authors":"Chihiro Nakayama, Takayuki Nojima","doi":"10.2183/pjab.102.023","DOIUrl":"https://doi.org/10.2183/pjab.102.023","url":null,"abstract":"Gene expression is determined by the right region and at the right time to shape a cellular function. To understand the landscape of gene expression, large-scale transcriptomic analyses for transcription start sites (where to start) have been employed. However, transcription termination sites (where to stop) and the regulatory mechanisms involved remain largely unclear. Recent studies with state-of-the-art technologies have revealed that RNA polymerase II (Pol II) termination sites are not exact gene ends, but rather within broad downstream-of-gene (DoG) regions. Restriction of DoG transcription contributes to efficient mRNA synthesis, whereas excessive or persistent DoG transcription caused by transcription termination defects blocks DNA replication and produces immunogenic nucleic acids. This review summarizes the latest findings on molecular mechanisms and biological impacts of Pol II transcription termination, and methodologies to investigate them. Finally, we discuss a potential application of Pol II transcription termination regulation for future research directions.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 8","pages":"288-302"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0