Conformational dynamics and molecular interactions of natural products: unveiling functional structures in biological membranes.

IF 4.4 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-03-31 DOI:10.2183/pjab.101.016

Michio Murata, Masayuki Satake, Nobuaki Matsumori

引用次数: 0

Abstract

Structural studies of natural products have been a driving force in the development of organic chemistry throughout its long history, especially in the early years. Recently, structure determination based on new concepts has also gained momentum. In this review we will mainly discuss the functional structures of natural products that account for the mechanisms of action largely from our studies. The topics include marine natural products, amphidinols, and ladder-shaped polyether compounds, which are known as potent antifungal agents and important marine biotoxins, respectively. Nuclear magnetic resonance studies for determining the stereochemistry of amphidinol 3 and its conformation in lipid-bilayer membranes will be presented in detail.

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天然产物的构象动力学和分子相互作用：揭示生物膜的功能结构。

天然产物的结构研究一直是有机化学发展的动力，特别是在有机化学发展的早期。最近，基于新概念的结构确定也得到了发展。在这篇综述中，我们将主要讨论天然产物的功能结构，这些结构在很大程度上解释了我们的研究中的作用机制。主题包括海洋天然产物、两苯二酚和阶梯状聚醚化合物，它们分别被认为是有效的抗真菌剂和重要的海洋生物毒素。本文将详细介绍用核磁共振技术测定两苯二酚3的立体化学及其在脂质双层膜中的构象。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences 生物-综合性期刊

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Proceedings of the Japan Academy Ser. B (PJA-B) is a scientific publication of the Japan Academy with a 90-year history, and covers all branches of natural sciences, except for mathematics, which is covered by the PJA-A. It is published ten times a year and is distributed widely throughout the world and can be read and obtained free of charge through the world wide web.