Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献_第2页

BRD9 at the crossroads of splicing, chromatin remodeling, and hematopoiesis. BRD9在剪接、染色质重塑和造血的十字路口。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.005

Takaya Yamasaki, Koutarou Nishimura, Daichi Inoue

{"title":"BRD9 at the crossroads of splicing, chromatin remodeling, and hematopoiesis.","authors":"Takaya Yamasaki, Koutarou Nishimura, Daichi Inoue","doi":"10.2183/pjab.102.005","DOIUrl":"10.2183/pjab.102.005","url":null,"abstract":"BAF complexes are ATP-dependent chromatin remodelers that govern gene expression and cellular identity. The non-canonical BAF (ncBAF) complex, with BRD9 as its signature component, orchestrates chromatin remodeling essential for balanced hematopoiesis. BRD9 loss disrupts enhancer-promoter interactions and CTCF-mediated chromatin architecture, causing myeloid skewing, impaired lymphoid differentiation, and diminished hematopoietic stem cell (HSC) fitness-phenotypes recapitulating physiological aging. This mechanism underlies aging-related pathologies such as myelodysplastic syndromes (MDS), in which spliceosomal mutations in SF3B1 trigger aberrant BRD9 splicing and destabilize its mRNA. Remarkably, BRD9 exhibits context-dependent functions: its depletion consistently promotes differentiation and apoptosis in myeloid leukemias, contrasting its differential roles in myeloid differentiation in adult versus fetal hematopoiesis. Thus, BRD9 mechanistically links spliceosomal dysfunction to chromatin dysregulation, bridging aging-associated disease and malignant transformation through context-dependent roles. Among the diverse assemblies of BAF family, these findings position the BRD9-ncBAF axis as both a critical determinant of hematopoietic fate decisions and a promising therapeutic target in hematologic malignancies.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 2","pages":"71-81"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13000111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146166419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extraterrestrial ³He flux variability during the Triassic recorded in pelagic bedded cherts of Japan. 日本远洋层状岩三叠纪记录的地球外氦通量变异性。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.012

Tetsuji Onoue, Kohei Setoyama, Honami Sato, Takuma Shiohara, Naoto Takahata

{"title":"Extraterrestrial 3He flux variability during the Triassic recorded in pelagic bedded cherts of Japan.","authors":"Tetsuji Onoue, Kohei Setoyama, Honami Sato, Takuma Shiohara, Naoto Takahata","doi":"10.2183/pjab.102.012","DOIUrl":"10.2183/pjab.102.012","url":null,"abstract":"Interplanetary dust particles are highly enriched with 3He implanted by the solar wind, enabling the reconstruction of extraterrestrial dust fluxes to Earth from sedimentary 3He records. However, the fluxes of extraterrestrial dust during periods predating the Cretaceous remain poorly constrained. In this study, we present the first comprehensive reconstruction of extraterrestrial 3He fluxes for much of the Triassic period (approximately 246-212 Ma) based on pelagic-bedded cherts preserved in Jurassic accretionary complexes in Japan. We reconstructed extraterrestrial 3He fluxes after correcting for dilution by radiolarian-derived biogenic silica. The records reveal long-term flux enhancements during the Ladinian and late Carnian (Tuvalian) intervals, reaching amplitudes approximately 2-3 times the background level and persisting for ∼3-4 Myr. These features are inconsistent with short-lived influx events, such as comet showers or asteroid breakups, and are instead comparable to long-term background variations in the Cretaceous and Cenozoic records. A sharp 3He flux peak at ∼215-216 Ma is accompanied by elevated 3He/4He ratios, indicating a sudden influx of fine-grained extraterrestrial material. The timing of this excursion closely coincides with the Manicouagan impact event (215.4 Ma), suggesting a link between asteroid disruption and enhanced dust production during the Triassic.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 5","pages":"167-178"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13276482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo-induced phase transition (PIPT): How it is advancing through collaborations with materials and measurement sciences. 光致相变（PIPT）：如何通过与材料和测量科学的合作来推进。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.017

Shinya Koshihara

{"title":"Photo-induced phase transition (PIPT): How it is advancing through collaborations with materials and measurement sciences.","authors":"Shinya Koshihara","doi":"10.2183/pjab.102.017","DOIUrl":"https://doi.org/10.2183/pjab.102.017","url":null,"abstract":"This study reviews developments in experimental studies of photo-induced cooperative phenomena (photo-induced phase transition, PIPT), which involve ultrafast dynamical changes in electronic, spin, and lattice structures. The growth in PIPT research has been driven by deep collaboration among quantum beam, materials, and theoretical sciences. In the early stages of PIPT research, it was thought that the dynamic PIPT process is dominated by energy relaxation from the photoexcited state, a process classified as classical and non-coherent. Using ultrashort-pulse quantum beam technologies, a new ordered phase, the \"hidden state\", unique to the photoexcited state, has been observed. In addition, modern laser technology has enabled control over the initial processes of PIPT, especially the formation of hidden states, through coherent coupling between a photon's electromagnetic field and the materials' electronic states. This review demonstrates that the PIPT control method has been extended from classical (non-coherent) to coherent processes (a class of quantum processes) through experimental results in collaboration with theoretical science.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 8","pages":"257-287"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glyoxalase activities of Parkinson's disease relevant protein DJ-1/PARK7: Past discoveries and future perspectives. 帕金森病相关蛋白DJ-1/PARK7的乙二醛酶活性：过去的发现和未来的展望

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.015

Shizuka Ogiwara, Masahiro Yamashina, Mark A Wilson, Noriyuki Matsuda

{"title":"Glyoxalase activities of Parkinson's disease relevant protein DJ-1/PARK7: Past discoveries and future perspectives.","authors":"Shizuka Ogiwara, Masahiro Yamashina, Mark A Wilson, Noriyuki Matsuda","doi":"10.2183/pjab.102.015","DOIUrl":"10.2183/pjab.102.015","url":null,"abstract":"Loss-of-function mutations in the evolutionarily conserved protein DJ-1/PARK7 cause autosomal recessive early-onset Parkinson's disease. Despite being identified more than 20 years ago, the authentic molecular function of DJ-1 remains controversial as diverse biochemical activities attributed to DJ-1 often lack a unified mechanistic explanation. In this review, we outline the hydrolase activities of DJ-1 (i.e., deglycase, protease, and esterase activities) before focusing on its glyoxalase activity, which catalyzes the glutathione-independent detoxification of reactive α-oxoaldehydes such as methylglyoxal. We summarize the historical identification of glyoxalase III activity, the discovery of bacterial and fungal DJ-1 homologs as methylglyoxalases, and the extension of this concept to human DJ-1. Structural and biochemical studies have clarified the molecular mechanism by which DJ-1 hydrolyzes glyoxal and methylglyoxal. In this mechanism, the conserved active-site cysteine residue (Cys106), together with neighboring residues, such as Glu18 and the Gly74-Gly75 oxyanion hole, cooperatively contribute to methylglyoxal degradation. These insights provide a coherent molecular framework that reconciles enzymatic activity with the structural features and evolutionary conservation of the DJ-1 family. Together, they provide a foundation for understanding the biological basis of DJ-1-mediated α-oxoaldehyde detoxification. Lastly, the limitations and unresolved questions of the DJ-1 glyoxalase hypothesis are discussed.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 6","pages":"214-227"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly polymorphic copy number variation in a segmental duplication in the mouse pseudoautosomal region even within inbred laboratory strains. 高多态性拷贝数变异在小鼠假常染色体区域的片段复制甚至在近交实验室菌株。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.009

Takaoki Kasahara

引用次数: 0

Reproductive phase and seawater temperature modulate locomotion and chemosensory-guided orientation in crown-of-thorns starfish. 繁殖阶段和海水温度调节棘冠海星的运动和化学感觉导向。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.019

Masumi Kamata, Takaya Kitamura, Tatsuki Koido, Takuma Mezaki, Nina Yasuda

{"title":"Reproductive phase and seawater temperature modulate locomotion and chemosensory-guided orientation in crown-of-thorns starfish.","authors":"Masumi Kamata, Takaya Kitamura, Tatsuki Koido, Takuma Mezaki, Nina Yasuda","doi":"10.2183/pjab.102.019","DOIUrl":"10.2183/pjab.102.019","url":null,"abstract":"Population outbreaks of crown-of-thorns starfish (COTS) are a major issue in the management of coral ecosystems. Elucidating foraging behavioral patterns in COTS caused by chemoreception is important understand because chemoreception is the principal sensory modality for prey detection in Asteroidea. Using Y-maze behavioral assays, we quantified how reproductive phase (pre- vs. post-spawning) and seawater temperature modulate (i) locomotor activity and (ii) odor-guided orientation toward live-coral cues in adult COTS. Elevated seawater temperature was associated with increased locomotion in COTS, likely caused by temperature-driven increases in metabolic rate. Y-maze experiments further indicated that COTS orientation toward prey chemical cues was greater during the pre-spawning period than during the post-spawning period. In line with heightened pre-reproductive nutritional demand, COTS were significantly more attracted to coral-derived chemical cues before spawning than afterward. These findings provide the first quantitative evidence that chemosensory-driven foraging in COTS is modulated by reproductive phase and seawater temperature.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 7","pages":"244-255"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13493200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148536654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spider silk-based structural proteins as tough, biodegradable, and sustainable polymers. 蜘蛛丝结构蛋白坚韧，可生物降解，可持续聚合物。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.003

Keiji Numata

引用次数: 0

Structural and dynamic heterogenization and phase transition in plastic crystal phase: Taking a representative molecular plastic crystal and an ionic one as examples. 塑料晶体相的结构和动态异质化与相变：以具有代表性的分子塑料晶体和离子塑料晶体为例。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.013

Keiko Nishikawa, Kozo Fujii

{"title":"Structural and dynamic heterogenization and phase transition in plastic crystal phase: Taking a representative molecular plastic crystal and an ionic one as examples.","authors":"Keiko Nishikawa, Kozo Fujii","doi":"10.2183/pjab.102.013","DOIUrl":"10.2183/pjab.102.013","url":null,"abstract":"A plastic crystal (PC) has a crystalline phase characterized by disordered molecular (or ionic) orientations while maintaining a regular lattice of their positions. It is in a molten state from the perspective of orientation, while in a crystalline state from the perspective of position. Recent studies have reported heterogeneous dynamics within the PC phase, regardless of whether it is a molecular PC (MPC) or an ionic PC (IPC). By measuring the spin-lattice relaxation time (T1) and the spin-spin relaxation time (T2) using low-frequency NMR, it is possible to separately observe the reorientation motion of molecules (or ions) from T1 and their translational motion from T2. We present the results of relaxation time measurements using an MPC and an IPC samples. The heterogeneous dynamics is attributed to the existence of static heterogeneous regions in the PC phase: the core region and the surrounding region enveloping it. We demonstrate that molecules (or ions) within each region exhibit distinct translational motion behaviors, with the surrounding region particularly leading to a pre-melting phenomenon. This heterogenization may be described \"a phase separation in solid phase\".","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 6","pages":"200-213"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148219162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioorganic studies on the nyctinastic leaf-movement of plants. 植物叶片动态运动的生物有机研究。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.002

Minoru Ueda, Yuki Muraoka

引用次数: 0

Molecular pathogenesis and evolving treatment landscape of extranodal NK/T-cell lymphoma. 结外NK/ t细胞淋巴瘤的分子发病机制及治疗进展。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2026-01-01 DOI: 10.2183/pjab.102.008

Junji Koya, Keisuke Kataoka

{"title":"Molecular pathogenesis and evolving treatment landscape of extranodal NK/T-cell lymphoma.","authors":"Junji Koya, Keisuke Kataoka","doi":"10.2183/pjab.102.008","DOIUrl":"10.2183/pjab.102.008","url":null,"abstract":"Extranodal NK/T-cell lymphoma (ENKTL) is a rare, aggressive Epstein-Barr virus (EBV)-associated malignancy. The 5th edition of the WHO classification refined their nomenclature by removing \"nasal type\" and introducing related entities to reflect updated biological insights. This review synthesizes recent advances in epidemiology and molecular pathogenesis in ENKTL, highlighting recurrent driver gene alterations, particularly frequent mutations in X-linked genes such as DDX3X and MSN, alongside TP53 mutations and PD-L1 structural variations that facilitate immune evasion. We also discuss novel mouse models that replicate the ENKTL niche, revealing how Trp53 loss and the EBV oncoprotein LMP1 synergistically remodel the tumor microenvironment to promote lymphomagenesis. Therapeutically, while L-asparaginase-based regimens including SMILE and P-GemOx remain the standard of care, emerging immune checkpoint inhibitors have demonstrated encouraging efficacy, particularly in combination with chemotherapy. This review provides an integrated perspective on the evolving landscape of diagnosis, disease biology, and translational treatment strategies for NK/T-cell lymphoproliferative disorders.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"102 3","pages":"105-113"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147435013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0