Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献

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Mechanisms of autophagosome formation. 自噬体的形成机制
IF 4.4 3区 综合性期刊
Yuko Fujioka, Nobuo N. Noda
{"title":"Mechanisms of autophagosome formation.","authors":"Yuko Fujioka, Nobuo N. Noda","doi":"10.2183/pjab.101.005","DOIUrl":"10.2183/pjab.101.005","url":null,"abstract":"<p><p>The formation of autophagosomes is a pivotal step in autophagy, a lysosomal degradation system that plays a crucial role in maintaining cellular homeostasis. After autophagy induction, phase separation of the autophagy-related (Atg) 1 complex occurs, facilitating the gathering of Atg proteins and organizes the autophagosome formation site, where the initial isolation membrane (IM)/phagophore is generated. The IM then expands after receiving phospholipids from endomembranes such as the endoplasmic reticulum. This process is driven by the collaboration of lipid transfer (Atg2) and scrambling (Atg9) proteins. The IM assumes a cup shaped morphology and undergoes closure, resulting in the formation of a double membrane-bound autophagosome. The Atg8 lipidation system is hypothesized to be a pivotal factor in this process. This review presents an overview of the current understanding of these processes and discusses the basic mechanisms of autophagosome formation.</p>","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 1","pages":"32-40"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pursuing the identity of a natural medicine licorice by Dr. Shoji Shibata that he firstly investigated half a century before. 寻找柴田正二博士在半个世纪前首次研究的天然药物甘草的身份。
IF 4.4 3区 综合性期刊
Michiho Ito
{"title":"Pursuing the identity of a natural medicine licorice by Dr. Shoji Shibata that he firstly investigated half a century before.","authors":"Michiho Ito","doi":"10.2183/pjab.101.018","DOIUrl":"10.2183/pjab.101.018","url":null,"abstract":"<p><p>This article is an explanatory review on a study of licorice stored in Shosoin Repository reported in this journal by Dr. Shoji Shibata in 2003 (Proc. Jpn. Acad. Ser. B 79, 176-180). The study using new technologies at that time for identification of plant species was a follow-up research of his own study performed half a century before. The study revised previous results and elucidated that the licorice stored in Shosoin Repository was derived from Glycyeehiza uralensis.</p>","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 5","pages":"239-248"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to "Dynamics of the nucleoside diphosphate kinase protein DYNAMO2 correlates with the changes in the global GTP level during the cell cycle of Cyanidioschyzon merolae". 更正“核苷二磷酸激酶蛋白DYNAMO2的动力学与Cyanidioschyzon merolae细胞周期中全球GTP水平的变化相关”。
IF 4.4 3区 综合性期刊
Yuuta Imoto, Yuichi Abe, Kanji Okumoto, Mio Ohnuma, Haruko Kuroiwa, Tsuneyoshi Kuroiwa, Yukio Fujiki
{"title":"Correction to \"Dynamics of the nucleoside diphosphate kinase protein DYNAMO2 correlates with the changes in the global GTP level during the cell cycle of Cyanidioschyzon merolae\".","authors":"Yuuta Imoto, Yuichi Abe, Kanji Okumoto, Mio Ohnuma, Haruko Kuroiwa, Tsuneyoshi Kuroiwa, Yukio Fujiki","doi":"10.2183/pjab.101.022","DOIUrl":"https://doi.org/10.2183/pjab.101.022","url":null,"abstract":"","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 6","pages":"371"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pathogenesis of type 2 diabetes in Japan and East Asian populations: Basic and clinical explorations. 日本和东亚人群2型糖尿病的发病机制:基础和临床探索。
IF 4.4 3区 综合性期刊
Yutaka Seino, Yuji Yamazaki
{"title":"Pathogenesis of type 2 diabetes in Japan and East Asian populations: Basic and clinical explorations.","authors":"Yutaka Seino, Yuji Yamazaki","doi":"10.2183/pjab.101.009","DOIUrl":"10.2183/pjab.101.009","url":null,"abstract":"<p><p>It is now accepted that the pathogenesis of type 2 diabetes in East Asians including Japanese differs distinctly from that in Caucasians. Many non-obese individuals in Japan develop type 2 diabetes and present clinically with insufficient insulin secretion rather than a large increase in the insulin resistance. To understand the pathophysiology of this non-obese diabetes, we studied Goto-Kakizaki rats, a unique model of spontaneous non-obese diabetes, and identified mitochondrial dysfunction in pancreatic β-cells as a factor in decreased insulin secretion. Looking for a clinical treatment option, we focused on the incretins because of their glucose-dependent insulin stimulatory effect. Our findings have contributed to the understanding of incretin action and the development of incretin-associated therapeutics and shed light on the nature of East Asian diabetes and its optimal clinical treatment.</p>","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 2","pages":"68-74"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First English article of Yagi-Uda antenna. 八木田天线的第一篇英文文章。
IF 4.4 3区 综合性期刊
Qiang Chen
{"title":"First English article of Yagi-Uda antenna.","authors":"Qiang Chen","doi":"10.2183/pjab.101.001","DOIUrl":"10.2183/pjab.101.001","url":null,"abstract":"<p><p>Herein, the first English article demonstrating the Yagi-Uda antenna is introduced. The article was originally published in the Proceedings of the Imperial Academy of Japan in 1926.</p>","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 1","pages":"1-7"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peaks in weak lensing mass maps for cluster astrophysics and cosmology. 星系团天体物理学和宇宙学中弱透镜质量图的峰值。
IF 4.4 3区 综合性期刊
Masamune Oguri, Satoshi Miyazaki
{"title":"Peaks in weak lensing mass maps for cluster astrophysics and cosmology.","authors":"Masamune Oguri, Satoshi Miyazaki","doi":"10.2183/pjab.101.010","DOIUrl":"10.2183/pjab.101.010","url":null,"abstract":"<p><p>Clusters of galaxies can be identified from the peaks in weak lensing aperture mass maps constructed from weak lensing shear catalogs. Such purely gravitational cluster selection differs considerably from traditional cluster selection based on the baryonic properties of clusters. In this review, we present the basics and applications of weak lensing shear-selected cluster samples. Detailed studies of the baryonic properties of shear-selected clusters shed new light on cluster astrophysics. The purely gravitational selection indicates that the selection function can be quantified more easily and robustly, which is crucial for deriving accurate cosmological constraints from the abundance of shear-selected clusters. Recent advances in shear-selected cluster studies are driven by the Subaru Hyper Suprime-Cam survey, in which more than 300 shear-selected clusters with a signal-to-noise ratio > 5 were identified. It is argued that various systematic effects in cosmological analysis can be mitigated by carefully selecting the setup of the analysis, including the selection of kernel functions and the source galaxy sample.</p>","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 3","pages":"129-142"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between typical fall patterns and fall-related fractures in older Japanese adults. 日本老年人典型跌倒方式与跌倒相关骨折的关系
IF 4.4 3区 综合性期刊
Minoru Yamada, Yusuke Terao, Iwao Kojima, Shu Tanaka, Hiroki Saegusa, Miho Nanbu, Shiho Soma, Hiroki Matsumoto, Masaya Saito, Kohei Okawa, Naoto Haga, Hidenori Arai
{"title":"Relationship between typical fall patterns and fall-related fractures in older Japanese adults.","authors":"Minoru Yamada, Yusuke Terao, Iwao Kojima, Shu Tanaka, Hiroki Saegusa, Miho Nanbu, Shiho Soma, Hiroki Matsumoto, Masaya Saito, Kohei Okawa, Naoto Haga, Hidenori Arai","doi":"10.2183/pjab.101.004","DOIUrl":"10.2183/pjab.101.004","url":null,"abstract":"<p><p>This study explored the relationship between fall patterns and fall-related fractures in older adults. A cross-sectional survey was conducted among community-dwelling older adults in Maibara City, Japan, focusing on falls over the past three years. Among the 1,695 reported falls, 176 fractures occurred in 120 individuals. Backward or straight-down and sideways falls were more likely to result in fractures compared to forward falls, with odds ratios (95% confidence interval) of 3.23 (2.08-5.02) and 3.68 (2.35-5.76), respectively. Falls triggered by slipping or loss of balance had higher fracture rates than those triggered by tripping. Specific fall patterns were associated with particular fractures, such as forearm and patella fractures from forward falls, spine fractures from backward or straight-down falls, and hip fractures from sideways falls. We conclude that the fracture risk varies significantly based on fall patterns, providing insights for enhancing fall prevention strategies.</p>","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 2","pages":"98-106"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Re-recognized universality of Kozai oscillation on three-body dynamics. 重新认识三体动力学上Kozai振荡的普遍性。
IF 4.4 3区 综合性期刊
Masanori Iye, Takashi Ito
{"title":"Re-recognized universality of Kozai oscillation on three-body dynamics.","authors":"Masanori Iye, Takashi Ito","doi":"10.2183/pjab.101.012","DOIUrl":"10.2183/pjab.101.012","url":null,"abstract":"<p><p>In 1962, Yoshihide Kozai reported his findings on the secular dynamics of asteroids moving in orbits with high inclination and eccentricity. In contrast to the classic understanding of the stability of planetary motion in the solar system, Kozai showed that asteroids can significantly change their orbital shape over a long timescale in an oscillatory manner between nearly circular orbits and highly elliptic orbits. An anti-correlated variation between orbital inclination and eccentricity characterizes this oscillation. The importance of Kozai's work in understanding the dynamical evolution of various systems was recognized decades later, including the fields of irregular satellites of planets, Oort Cloud, extrasolar planets, binary star systems, type Ia supernovae, planet climate, merging black hole systems, and so on.</p>","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 3","pages":"143-176"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural determination of mugineic acid, an iron(III)-chelating substance secreted from graminaceous plants for efficient iron uptake. 禾本科植物分泌的铁(III)螯合物质mugineic酸的结构测定。
IF 4.4 3区 综合性期刊
Takanori Kobayashi, Naoko K Nishizawa
{"title":"Structural determination of mugineic acid, an iron(III)-chelating substance secreted from graminaceous plants for efficient iron uptake.","authors":"Takanori Kobayashi, Naoko K Nishizawa","doi":"10.2183/pjab.101.007","DOIUrl":"10.2183/pjab.101.007","url":null,"abstract":"<p><p>Iron is an essential element for organisms, but its solubility in soil is often extremely low. Previously, plants were considered to take up iron only after its reduction to ferrous ions. Takagi reported that oat and rice secrete chelating substances that solubilize ferric iron in the rhizosphere for efficient iron uptake. In 1978, Takemoto et al. reported the chemical structure of an iron-chelating compound secreted from barley roots, designated as mugineic acid. Mugineic acid and its derivatives, collectively known as mugineic acid family phytosiderophores (MAs), chelate ferric iron using octahedral hexacoordination. The specific iron uptake system by MAs in graminaceous plants was later classified by Römheld and Marschner as Strategy II, in contrast to Strategy I for reduction-based iron uptake by non-graminaceous plants. Further studies on MAs by Japanese researchers led to the identification of their biosynthetic pathways, corresponding enzymes and encoding genes, their regulation mechanisms, and the production of iron deficiency-tolerant and iron-rich crops.</p>","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 2","pages":"55-67"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dawn of photoredox catalysis. 光氧化还原催化的曙光。
IF 4.4 3区 综合性期刊
Munetaka Akita
{"title":"Dawn of photoredox catalysis.","authors":"Munetaka Akita","doi":"10.2183/pjab.101.019","DOIUrl":"https://doi.org/10.2183/pjab.101.019","url":null,"abstract":"<p><p>Photoredox catalysis, which facilitates organic transformations under visible-light irradiation, including sunlight, has garnered considerable attention as a cornerstone of green chemistry. Since the early days of this field around 2010, the author's group has made substantial contributions to its advancement. This review article provides a concise overview of the history and fundamental principles of photoredox catalysis, along with highlights of the achievements by the author's group. Although colorless organic compounds cannot be directly activated by visible light, photo-excited colored catalysts, with their two half-occupied frontier orbitals, play dual roles via electron transfer processes with organic substrates. The hole in the lower-energy orbital functions as a single-electron oxidant, whereas the electron in the higher-energy orbital acts as a single-electron reductant, enabling the formation of reactive radical intermediates from diverse organic compounds, including colorless ones. The discussion will focus on the key transformations developed by the author's group, including bimetallic photocatalysis, fluoroalkylation, and catalysis in aqueous media.</p>","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 5","pages":"274-301"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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