Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献_第2页

Whole-genome sequencing analysis of volvocine green algae reveals the molecular genetic basis for the diversity and evolution of sex. 伏藻绿藻全基因组测序分析揭示了性别多样性和进化的分子遗传基础。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.029

Hisayoshi Nozaki, Kayoko Yamamoto, Kohei Takahashi

{"title":"Whole-genome sequencing analysis of volvocine green algae reveals the molecular genetic basis for the diversity and evolution of sex.","authors":"Hisayoshi Nozaki, Kayoko Yamamoto, Kohei Takahashi","doi":"10.2183/pjab.100.029","DOIUrl":"10.2183/pjab.100.029","url":null,"abstract":"This review describes the development of evolutionary studies of sex based on the volvocine lineage of green algae, which was facilitated by whole-genome analyses of both model and non-model species. Volvocine algae, which include Chlamydomonas and Volvox species, have long been considered a model group for experimental studies investigating the evolution of sex. Thus, whole-genomic information on the sex-determining regions of volvocine algal sex chromosomes has been sought to elucidate the molecular genetic basis of sex evolution. By 2010, whole genomes were published for two model species in this group, Chlamydomonas reinhardtii and Volvox carteri. Recent improvements in sequencing technology, particularly next-generation sequencing, allowed our studies to obtain complete genomes for non-model, but evolutionary important, volvocine algal species. These genomes have provided critical details about sex-determining regions that will contribute to our understanding of the diversity and evolution of sex.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 8","pages":"465-475"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical mechanism of core-collapse supernovae that neutrinos drive. 中微子驱动核心坍缩超新星的物理机制。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.015

Shoichi Yamada, Hiroki Nagakura, Ryuichiro Akaho, Akira Harada, Shun Furusawa, Wakana Iwakami, Hirotada Okawa, Hideo Matsufuru, Kohsuke Sumiyoshi

引用次数: 0

Discovery of internal rotation and conformers of 1,2-dichloroethane: the dawn of the concept of conformation. 发现 1,2-二氯乙烷的内旋转和构象：构象概念的曙光。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.003

Shinji Toyota

{"title":"Discovery of internal rotation and conformers of 1,2-dichloroethane: the dawn of the concept of conformation.","authors":"Shinji Toyota","doi":"10.2183/pjab.100.003","DOIUrl":"10.2183/pjab.100.003","url":null,"abstract":"In 1932, Mizushima and Higasi reported the dependence of the dipole moments of 1,2-dichloroethane on both temperature and solvent in the Proceedings of the Imperial Academy, Japan. This report was followed by their first proposal of the existence of conformers that exchanged by internal rotation about a C-C single bond based on experimental data. Their monumental work marked the beginning of the essential concept of conformation in modern stereochemistry. Their proposal was later confirmed by the direct observation of the anti and gauche conformers of 1,2-dichloroethane by Raman spectroscopy, and further supported by other experimental and theoretical methods. The relative stabilities of the anti and gauche conformers of 1,2-dichloroethane and other 1,2-disubstituted ethanes were discussed in terms of steric, electrostatic, and stereoelectronic effects based on analysis of calculated data. Those studies influenced the development of subsequent research in organic chemistry, such as the conformational analysis of cyclohexane derivatives and the isolation of chiral gauche conformers.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 2","pages":"101-113"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10978969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The discovery of acatalasemia (lack of catalase in the blood) and its significance in human genetics. 发现过氧化氢酶血症（血液中缺乏过氧化氢酶）及其在人类遗传学中的意义。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.024

Mizuo Ando, Kunihiro Fukushima, Kazunori Nishizaki

引用次数: 0

Tracing the genealogy of research on the mechanism of blue flower coloration by anthocyanin based on Keita Shibata's work. 以柴田庆太的研究为基础，追溯花青素蓝花着色机理的研究谱系。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.028

Kumi Yoshida

引用次数: 0

Establishment of immune suppression by cancer cells in the tumor microenvironment. 癌细胞在肿瘤微环境中建立免疫抑制。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.005

Hiroyoshi Nishikawa

{"title":"Establishment of immune suppression by cancer cells in the tumor microenvironment.","authors":"Hiroyoshi Nishikawa","doi":"10.2183/pjab.100.005","DOIUrl":"10.2183/pjab.100.005","url":null,"abstract":"With the clinical success of immune checkpoint inhibitors (ICIs), cancer immunotherapy has become an important pillar of cancer treatment in various types of cancer. However, more than half of patients fail to respond to ICIs, even in combination, uncovering a limited window of clinical responses. Therefore, it is essential to develop more effective cancer immunotherapies and to define biomarkers for stratifying responders and nonresponders by exploring the immunological landscape in the tumor microenvironment (TME). It has become clear that differences in immune responses in the TME determine the clinical efficacy of cancer immunotherapies. Additionally, gene alterations in cancer cells contribute to the development of the immunological landscape, particularly immune suppression in the TME. Therefore, integrated analyses of immunological and genomic assays are key for understanding diverse immune suppressive mechanisms in the TME. Developing novel strategies to control immune suppression in the TME from the perspective of immunology and the cancer genome is crucial for effective cancer immunotherapy (immune-genome precision medicine).","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 2","pages":"114-122"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10978970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytochrome c oxidase subunit I gene in Thalassiosira nordenskioeldii strains inhabiting in cold and warm sea waters. 栖息于寒冷和温暖海水中的 Thalassiosira nordenskioeldii 菌株的细胞色素 c 氧化酶亚单位 I 基因。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.010

Yoshie Uchida, Hidenobu Uchida, Takeshi Sato, Yuko Nishimoto, Koichi Tsutsumi, Takao Oi, Mitsutaka Taniguchi, Kazuhito Inoue, Yoshihiro Suzuki

{"title":"Cytochrome c oxidase subunit I gene in Thalassiosira nordenskioeldii strains inhabiting in cold and warm sea waters.","authors":"Yoshie Uchida, Hidenobu Uchida, Takeshi Sato, Yuko Nishimoto, Koichi Tsutsumi, Takao Oi, Mitsutaka Taniguchi, Kazuhito Inoue, Yoshihiro Suzuki","doi":"10.2183/pjab.100.010","DOIUrl":"10.2183/pjab.100.010","url":null,"abstract":"From the biota beneath the sea ice in Lake Saroma, which is adjacent to Sea of Okhotsk, a diatom culture of Saroma 16 was isolated. Strutted processes and a labiate process in Saroma 16 were characteristic of those in Thalassiosira nordenskioeldii. Similarity search analysis showed that the 826-bp rbcL-3P region sequence of this strain was 100% identical to multiple sequences registered as T. nordenskioeldii in a public database. The 4305-bp PCR-amplified mitochondrial cytochrome c oxidase subunit I (COI) gene (COI)-5P region of Saroma 16 included a 1060-bp open reading frame (ORF), which was interrupted by 934-bp and 2311-bp introns that included frame-shifted ORFs encoding reverse-transcriptase (RTase)-like proteins. Previous reports showed that a strain of the same species, CNS00052, originating from the East China Sea included no introns in the COI, whereas North Atlantic Ocean strains of the same species, such as CCMP992, CCMP993, and CCMP997, included a 2.3-kb intron in the same position as Saroma 16.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 2","pages":"140-148"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10978971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chondroitin sulfate proteoglycan 4: An attractive target for antibody-based immunotherapy. 硫酸软骨素蛋白多糖 4：基于抗体的免疫疗法的诱人靶点。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.019

Tomohiro Kurokawa, Kohzoh Imai

{"title":"Chondroitin sulfate proteoglycan 4: An attractive target for antibody-based immunotherapy.","authors":"Tomohiro Kurokawa, Kohzoh Imai","doi":"10.2183/pjab.100.019","DOIUrl":"10.2183/pjab.100.019","url":null,"abstract":"Multifunctional molecules involved in tumor progression and metastasis have been identified as valuable targets for immunotherapy. Among these, chondroitin sulfate proteoglycan 4 (CSPG4), a significant tumor cell membrane-bound proteoglycan, has emerged as a promising target, especially in light of advances in chimeric antigen receptor (CAR) T-cell therapy. The profound bioactivity of CSPG4 and its role in pivotal processes such as tumor proliferation, migration, and neoangiogenesis underline its therapeutic potential. We reviewed the molecular intricacies of CSPG4, its functional attributes within tumor cells, and the latest clinical-translational advances targeting it. Strategies such as blocking monoclonal antibodies, conjugate therapies, bispecific antibodies, small-molecule inhibitors, CAR T-cell therapies, trispecific killer engagers, and ribonucleic acid vaccines against CSPG4 were assessed. CSPG4 overexpression in diverse tumors and its correlation with adverse prognostic outcomes emphasize its significance in cancer biology. These findings suggest that targeting CSPG4 offers a promising avenue for future cancer therapy, with potential synergistic effects when combined with existing treatments.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 5","pages":"293-308"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11260911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studies on "Ascites sarcoma". 关于 "腹水肉瘤 "的研究。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.021

Tomoyuki Kitagawa

引用次数: 0

Crystals of taka-amylase A, a cornerstone of protein chemistry in Japan. 日本蛋白质化学的基石--高淀粉酶 A 的晶体。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.027

Saburo Aimoto, Naoto Minamino, Takeshi Ishimizu, Masami Kusunoki

引用次数: 0