Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献_第3页

Optical coupling of individual air-suspended carbon nanotubes to silicon microcavities. 单个空气悬浮碳纳米管与硅微腔的光学耦合。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.022

Wataru Terashima, Yuichiro K Kato

引用次数: 0

Report on the mutagenicity of flavone derivatives and their contribution to advancing scientific knowledge. 黄酮衍生物的致突变性及其对推进科学知识的贡献的报告。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.032

Yukari Totsuka, Keiji Wakabayashi

{"title":"Report on the mutagenicity of flavone derivatives and their contribution to advancing scientific knowledge.","authors":"Yukari Totsuka, Keiji Wakabayashi","doi":"10.2183/pjab.100.032","DOIUrl":"10.2183/pjab.100.032","url":null,"abstract":"Flavonoids, such as quercetin and kaempferol, and their glycosides, are widely distributed in vegetables and fruits. Sugimura, T. et al. investigated the mutagenicity of flavone derivatives, and found that quercetin and kaempferol showed high mutagenic activities in Salmonella typhimurium TA98 with S9 mix, comparable to that of the typical carcinogen, benzo[a]pyrene. These novel findings were published in Proc. Jpn. Acad. Ser. B 53, 194-197, 1977. Other research groups also reported the mutagenic properties of flavone derivatives in S. typhimurium strains. These observations led to the commencement of long-term animal carcinogenesis experiments involving quercetin. A USA-Turkey joint study reported that feeding rats with 0.1% quercetin in the diet produced carcinomas. However, Japanese scientists showed no carcinogenicity with quercetin in rats, mice, or hamsters, even at 10% in the diet. NTP Technical Report on the Toxicology and Carcinogenesis Studies of Quercetin in F344/N Rats concluded that there was no evidence of its carcinogenic activity. Therefore, the potential risk of quercetin in human cancers is likely to be negligible. These flavonoid issues provided a warning regarding the simplistic understanding that mutagens are carcinogens, and microbial tests alone are inadequate for safety assessment; therefore, and a battery of tests for genotoxicity is recommended. Thus, the informative report in 1977 made significant contributions to initiating and promoting genotoxicity studies of flavonoids.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 10","pages":"537-544"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical characterization of heavy actinides and light transactinides - Experimental achievements at JAEA. 重锕系元素和轻锕系元素的化学特征 - JAEA 的实验成就。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.011

Yuichiro Nagame, Tetsuya K Sato

引用次数: 0

Biomimetic polymers with phosphorylcholine groups as biomaterials for medical devices. 含磷胆碱基团的仿生聚合物作为医疗器械的生物材料。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.037

Kazuhiko Ishihara

{"title":"Biomimetic polymers with phosphorylcholine groups as biomaterials for medical devices.","authors":"Kazuhiko Ishihara","doi":"10.2183/pjab.100.037","DOIUrl":"10.2183/pjab.100.037","url":null,"abstract":"Biomimetic molecular designs can yield superior biomaterials. Polymers with a phosphorylcholine group, a polar group of phospholipid molecules, are particularly interesting. A methacrylate monomer, 2-methacryloyloxyethyl phosphorylcholine (MPC), was developed using efficient synthetic reactions and purification techniques. This process has been applied in industrial production to supply MPC globally. Polymers with various structures can be readily synthesized using MPC and their properties have been studied. The MPC polymer surface has a highly hydrated structure in biological conditions, leading to the prevention of adsorption of proteins and lipid molecules, adhesion of cells, and inhibition of bacterial adhesion and biofilm formation. Additionally, it provides an extremely lubricious surface. MPC polymers are used in various applications and can be stably immobilized on material surfaces such as metals and ceramics and polymers such as elastomers. They are also stable under sterilization and in vivo conditions. This makes them ideal for application in the surface treatment of various medical devices, including artificial organs, implanted in humans.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 10","pages":"579-606"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-genome sequencing analysis of volvocine green algae reveals the molecular genetic basis for the diversity and evolution of sex. 伏藻绿藻全基因组测序分析揭示了性别多样性和进化的分子遗传基础。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.029

Hisayoshi Nozaki, Kayoko Yamamoto, Kohei Takahashi

{"title":"Whole-genome sequencing analysis of volvocine green algae reveals the molecular genetic basis for the diversity and evolution of sex.","authors":"Hisayoshi Nozaki, Kayoko Yamamoto, Kohei Takahashi","doi":"10.2183/pjab.100.029","DOIUrl":"10.2183/pjab.100.029","url":null,"abstract":"This review describes the development of evolutionary studies of sex based on the volvocine lineage of green algae, which was facilitated by whole-genome analyses of both model and non-model species. Volvocine algae, which include Chlamydomonas and Volvox species, have long been considered a model group for experimental studies investigating the evolution of sex. Thus, whole-genomic information on the sex-determining regions of volvocine algal sex chromosomes has been sought to elucidate the molecular genetic basis of sex evolution. By 2010, whole genomes were published for two model species in this group, Chlamydomonas reinhardtii and Volvox carteri. Recent improvements in sequencing technology, particularly next-generation sequencing, allowed our studies to obtain complete genomes for non-model, but evolutionary important, volvocine algal species. These genomes have provided critical details about sex-determining regions that will contribute to our understanding of the diversity and evolution of sex.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 8","pages":"465-475"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the expression of mexB, mexY, and oprD in clinical Pseudomonas aeruginosa isolates. 临床铜绿假单胞菌分离物中 mexB、mexY 和 oprD 表达的变化。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.006

Yoshimi Matsumoto, Seiji Yamasaki, Kouhei Hayama, Ryota Iino, Hiroyuki Noji, Akihito Yamaguchi, Kunihiko Nishino

{"title":"Changes in the expression of mexB, mexY, and oprD in clinical Pseudomonas aeruginosa isolates.","authors":"Yoshimi Matsumoto, Seiji Yamasaki, Kouhei Hayama, Ryota Iino, Hiroyuki Noji, Akihito Yamaguchi, Kunihiko Nishino","doi":"10.2183/pjab.100.006","DOIUrl":"10.2183/pjab.100.006","url":null,"abstract":"Changes in expression levels of drug efflux pump genes, mexB and mexY, and porin gene oprD in Pseudomonas aeruginosa were investigated in this study. Fifty-five multidrug-resistant P. aeruginosa (MDRP) strains were compared with 26 drug-sensitive strains and 21 strains resistant to a single antibiotic. The effect of the efflux inhibitor Phe-Arg-β-naphthylamide on drug susceptibility was determined, and gene expression was quantified using real-time quantitative real-time reverse transcription polymerase chain reaction. In addition, the levels of metallo-β-lactamase (MBL) and 6'-N-aminoglycoside acetyltransferase [AAC(6')-Iae] were investigated. Efflux pump inhibitor treatment increased the sensitivity to ciprofloxacin, aztreonam, and imipenem in 71%, 73%, and 29% of MDRPs, respectively. MBL and AAC(6')-Iae were detected in 38 (69%) and 34 (62%) MDRP strains, respectively. Meanwhile, 76% of MDRP strains exhibited more than 8-fold higher mexY expression than the reference strain PAO1. Furthermore, 69% of MDRP strains expressed oprD at levels less than 0.01-fold of those in PAO1. These findings indicated that efflux pump inhibitors in combination with ciprofloxacin or aztreonam might aid in treating MDRP infections.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 1","pages":"57-67"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Control of interface functions in solid-state biosensors for stable detection of molecular recognition. 控制固态生物传感器的界面功能，实现分子识别的稳定检测。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.004

Miyuki Tabata, Yuji Miyahara

{"title":"Control of interface functions in solid-state biosensors for stable detection of molecular recognition.","authors":"Miyuki Tabata, Yuji Miyahara","doi":"10.2183/pjab.100.004","DOIUrl":"10.2183/pjab.100.004","url":null,"abstract":"Significant progress has been achieved in the field of solid-state biosensors over the past 50 years. Various sensing devices with high-density integration and flexible configuration, as well as new applications for clinical diagnosis and healthcare, have been developed using blood, serum, and other body fluids such as sweat, tears, and saliva. A high-density array of ion-sensitive field effect transistors was developed by exploiting the advantages of advanced semiconductor technologies and commercialized in combination with an enzymatic primer extension reaction as a DNA sequencer in 2011. Different types of materials such as inorganic materials, metals, polymers, and biomolecules are mixed together on the surface of the gate while maintaining their own functions; therefore, compatibility among different materials has to be optimized so that the best detection performance of solid-state biosensors, including stability and reliability, is achieved as designed. Solid-state biosensors are suitable for the rapid, cost-effective, and noninvasive identification of biomarkers at various timepoints over the course of a disease.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 1","pages":"32-56"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kaonic nuclear clusters- a new paradigm of particle and nuclear physics. Kaonic核团簇-粒子和核物理学的新范例。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.039

Yoshinori Akaishi, Toshimitsu Yamazaki

{"title":"Kaonic nuclear clusters- a new paradigm of particle and nuclear physics.","authors":"Yoshinori Akaishi, Toshimitsu Yamazaki","doi":"10.2183/pjab.100.039","DOIUrl":"10.2183/pjab.100.039","url":null,"abstract":"Λ＊ = Λ(1405) plays an essential role in the formation of kaonic nuclear clusters (KNC). The simplest KNC, K－pp, has the structure Λ＊p = (K－p)I=0p, in which a real kaon migrates between two nucleons, mediating super-strong Λ＊p attraction. Production data of K－pp have been accumulated by DISTO, J-PARC E27 and J-PARC E15 experiments. For K－K－pp the attractive covalent bond of Λ＊Λ＊ is doubly enhanced compared to the Λ＊p one. Consequently, Λ＊ multiplet, (Λ＊)m, with m(m－1)/2 bonds becomes more stable than its corresponding neutron aggregate, (n)m, at m = 8－12, suggesting the possible existence of stable Λ＊ matter. A long-lived strangelet of (Λ＊)m=6 is presumed as a precursor. The production of K－K－pp by high-energy pp or heavy-ion collisions is awaited as a doorway to so-far unknown Λ＊ matter.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 10","pages":"607-614"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The discovery of acatalasemia (lack of catalase in the blood) and its significance in human genetics. 发现过氧化氢酶血症（血液中缺乏过氧化氢酶）及其在人类遗传学中的意义。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.024

Mizuo Ando, Kunihiro Fukushima, Kazunori Nishizaki

引用次数: 0

Physical mechanism of core-collapse supernovae that neutrinos drive. 中微子驱动核心坍缩超新星的物理机制。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.015

Shoichi Yamada, Hiroki Nagakura, Ryuichiro Akaho, Akira Harada, Shun Furusawa, Wakana Iwakami, Hirotada Okawa, Hideo Matsufuru, Kohsuke Sumiyoshi

引用次数: 0