Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献_第4页

Whole-genome sequencing analysis of volvocine green algae reveals the molecular genetic basis for the diversity and evolution of sex. 伏藻绿藻全基因组测序分析揭示了性别多样性和进化的分子遗传基础。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.029

Hisayoshi Nozaki, Kayoko Yamamoto, Kohei Takahashi

{"title":"Whole-genome sequencing analysis of volvocine green algae reveals the molecular genetic basis for the diversity and evolution of sex.","authors":"Hisayoshi Nozaki, Kayoko Yamamoto, Kohei Takahashi","doi":"10.2183/pjab.100.029","DOIUrl":"10.2183/pjab.100.029","url":null,"abstract":"This review describes the development of evolutionary studies of sex based on the volvocine lineage of green algae, which was facilitated by whole-genome analyses of both model and non-model species. Volvocine algae, which include Chlamydomonas and Volvox species, have long been considered a model group for experimental studies investigating the evolution of sex. Thus, whole-genomic information on the sex-determining regions of volvocine algal sex chromosomes has been sought to elucidate the molecular genetic basis of sex evolution. By 2010, whole genomes were published for two model species in this group, Chlamydomonas reinhardtii and Volvox carteri. Recent improvements in sequencing technology, particularly next-generation sequencing, allowed our studies to obtain complete genomes for non-model, but evolutionary important, volvocine algal species. These genomes have provided critical details about sex-determining regions that will contribute to our understanding of the diversity and evolution of sex.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 8","pages":"465-475"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the expression of mexB, mexY, and oprD in clinical Pseudomonas aeruginosa isolates. 临床铜绿假单胞菌分离物中 mexB、mexY 和 oprD 表达的变化。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.006

Yoshimi Matsumoto, Seiji Yamasaki, Kouhei Hayama, Ryota Iino, Hiroyuki Noji, Akihito Yamaguchi, Kunihiko Nishino

{"title":"Changes in the expression of mexB, mexY, and oprD in clinical Pseudomonas aeruginosa isolates.","authors":"Yoshimi Matsumoto, Seiji Yamasaki, Kouhei Hayama, Ryota Iino, Hiroyuki Noji, Akihito Yamaguchi, Kunihiko Nishino","doi":"10.2183/pjab.100.006","DOIUrl":"10.2183/pjab.100.006","url":null,"abstract":"Changes in expression levels of drug efflux pump genes, mexB and mexY, and porin gene oprD in Pseudomonas aeruginosa were investigated in this study. Fifty-five multidrug-resistant P. aeruginosa (MDRP) strains were compared with 26 drug-sensitive strains and 21 strains resistant to a single antibiotic. The effect of the efflux inhibitor Phe-Arg-β-naphthylamide on drug susceptibility was determined, and gene expression was quantified using real-time quantitative real-time reverse transcription polymerase chain reaction. In addition, the levels of metallo-β-lactamase (MBL) and 6'-N-aminoglycoside acetyltransferase [AAC(6')-Iae] were investigated. Efflux pump inhibitor treatment increased the sensitivity to ciprofloxacin, aztreonam, and imipenem in 71%, 73%, and 29% of MDRPs, respectively. MBL and AAC(6')-Iae were detected in 38 (69%) and 34 (62%) MDRP strains, respectively. Meanwhile, 76% of MDRP strains exhibited more than 8-fold higher mexY expression than the reference strain PAO1. Furthermore, 69% of MDRP strains expressed oprD at levels less than 0.01-fold of those in PAO1. These findings indicated that efflux pump inhibitors in combination with ciprofloxacin or aztreonam might aid in treating MDRP infections.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 1","pages":"57-67"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Control of interface functions in solid-state biosensors for stable detection of molecular recognition. 控制固态生物传感器的界面功能，实现分子识别的稳定检测。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.004

Miyuki Tabata, Yuji Miyahara

{"title":"Control of interface functions in solid-state biosensors for stable detection of molecular recognition.","authors":"Miyuki Tabata, Yuji Miyahara","doi":"10.2183/pjab.100.004","DOIUrl":"10.2183/pjab.100.004","url":null,"abstract":"Significant progress has been achieved in the field of solid-state biosensors over the past 50 years. Various sensing devices with high-density integration and flexible configuration, as well as new applications for clinical diagnosis and healthcare, have been developed using blood, serum, and other body fluids such as sweat, tears, and saliva. A high-density array of ion-sensitive field effect transistors was developed by exploiting the advantages of advanced semiconductor technologies and commercialized in combination with an enzymatic primer extension reaction as a DNA sequencer in 2011. Different types of materials such as inorganic materials, metals, polymers, and biomolecules are mixed together on the surface of the gate while maintaining their own functions; therefore, compatibility among different materials has to be optimized so that the best detection performance of solid-state biosensors, including stability and reliability, is achieved as designed. Solid-state biosensors are suitable for the rapid, cost-effective, and noninvasive identification of biomarkers at various timepoints over the course of a disease.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 1","pages":"32-56"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10864167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139417930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kaonic nuclear clusters- a new paradigm of particle and nuclear physics. Kaonic核团簇-粒子和核物理学的新范例。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.039

Yoshinori Akaishi, Toshimitsu Yamazaki

{"title":"Kaonic nuclear clusters- a new paradigm of particle and nuclear physics.","authors":"Yoshinori Akaishi, Toshimitsu Yamazaki","doi":"10.2183/pjab.100.039","DOIUrl":"10.2183/pjab.100.039","url":null,"abstract":"Λ＊ = Λ(1405) plays an essential role in the formation of kaonic nuclear clusters (KNC). The simplest KNC, K－pp, has the structure Λ＊p = (K－p)I=0p, in which a real kaon migrates between two nucleons, mediating super-strong Λ＊p attraction. Production data of K－pp have been accumulated by DISTO, J-PARC E27 and J-PARC E15 experiments. For K－K－pp the attractive covalent bond of Λ＊Λ＊ is doubly enhanced compared to the Λ＊p one. Consequently, Λ＊ multiplet, (Λ＊)m, with m(m－1)/2 bonds becomes more stable than its corresponding neutron aggregate, (n)m, at m = 8－12, suggesting the possible existence of stable Λ＊ matter. A long-lived strangelet of (Λ＊)m=6 is presumed as a precursor. The production of K－K－pp by high-energy pp or heavy-ion collisions is awaited as a doorway to so-far unknown Λ＊ matter.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 10","pages":"607-614"},"PeriodicalIF":4.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11704456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The discovery of acatalasemia (lack of catalase in the blood) and its significance in human genetics. 发现过氧化氢酶血症（血液中缺乏过氧化氢酶）及其在人类遗传学中的意义。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.024

Mizuo Ando, Kunihiro Fukushima, Kazunori Nishizaki

引用次数: 0

Physical mechanism of core-collapse supernovae that neutrinos drive. 中微子驱动核心坍缩超新星的物理机制。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.015

Shoichi Yamada, Hiroki Nagakura, Ryuichiro Akaho, Akira Harada, Shun Furusawa, Wakana Iwakami, Hirotada Okawa, Hideo Matsufuru, Kohsuke Sumiyoshi

引用次数: 0

Discovery of internal rotation and conformers of 1,2-dichloroethane: the dawn of the concept of conformation. 发现 1,2-二氯乙烷的内旋转和构象：构象概念的曙光。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.003

Shinji Toyota

{"title":"Discovery of internal rotation and conformers of 1,2-dichloroethane: the dawn of the concept of conformation.","authors":"Shinji Toyota","doi":"10.2183/pjab.100.003","DOIUrl":"10.2183/pjab.100.003","url":null,"abstract":"In 1932, Mizushima and Higasi reported the dependence of the dipole moments of 1,2-dichloroethane on both temperature and solvent in the Proceedings of the Imperial Academy, Japan. This report was followed by their first proposal of the existence of conformers that exchanged by internal rotation about a C-C single bond based on experimental data. Their monumental work marked the beginning of the essential concept of conformation in modern stereochemistry. Their proposal was later confirmed by the direct observation of the anti and gauche conformers of 1,2-dichloroethane by Raman spectroscopy, and further supported by other experimental and theoretical methods. The relative stabilities of the anti and gauche conformers of 1,2-dichloroethane and other 1,2-disubstituted ethanes were discussed in terms of steric, electrostatic, and stereoelectronic effects based on analysis of calculated data. Those studies influenced the development of subsequent research in organic chemistry, such as the conformational analysis of cyclohexane derivatives and the isolation of chiral gauche conformers.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 2","pages":"101-113"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10978969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracing the genealogy of research on the mechanism of blue flower coloration by anthocyanin based on Keita Shibata's work. 以柴田庆太的研究为基础，追溯花青素蓝花着色机理的研究谱系。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.028

Kumi Yoshida

引用次数: 0

Establishment of immune suppression by cancer cells in the tumor microenvironment. 癌细胞在肿瘤微环境中建立免疫抑制。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.005

Hiroyoshi Nishikawa

{"title":"Establishment of immune suppression by cancer cells in the tumor microenvironment.","authors":"Hiroyoshi Nishikawa","doi":"10.2183/pjab.100.005","DOIUrl":"10.2183/pjab.100.005","url":null,"abstract":"With the clinical success of immune checkpoint inhibitors (ICIs), cancer immunotherapy has become an important pillar of cancer treatment in various types of cancer. However, more than half of patients fail to respond to ICIs, even in combination, uncovering a limited window of clinical responses. Therefore, it is essential to develop more effective cancer immunotherapies and to define biomarkers for stratifying responders and nonresponders by exploring the immunological landscape in the tumor microenvironment (TME). It has become clear that differences in immune responses in the TME determine the clinical efficacy of cancer immunotherapies. Additionally, gene alterations in cancer cells contribute to the development of the immunological landscape, particularly immune suppression in the TME. Therefore, integrated analyses of immunological and genomic assays are key for understanding diverse immune suppressive mechanisms in the TME. Developing novel strategies to control immune suppression in the TME from the perspective of immunology and the cancer genome is crucial for effective cancer immunotherapy (immune-genome precision medicine).","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 2","pages":"114-122"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10978970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytochrome c oxidase subunit I gene in Thalassiosira nordenskioeldii strains inhabiting in cold and warm sea waters. 栖息于寒冷和温暖海水中的 Thalassiosira nordenskioeldii 菌株的细胞色素 c 氧化酶亚单位 I 基因。

IF 3.1 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2024-01-01 DOI: 10.2183/pjab.100.010

Yoshie Uchida, Hidenobu Uchida, Takeshi Sato, Yuko Nishimoto, Koichi Tsutsumi, Takao Oi, Mitsutaka Taniguchi, Kazuhito Inoue, Yoshihiro Suzuki

{"title":"Cytochrome c oxidase subunit I gene in Thalassiosira nordenskioeldii strains inhabiting in cold and warm sea waters.","authors":"Yoshie Uchida, Hidenobu Uchida, Takeshi Sato, Yuko Nishimoto, Koichi Tsutsumi, Takao Oi, Mitsutaka Taniguchi, Kazuhito Inoue, Yoshihiro Suzuki","doi":"10.2183/pjab.100.010","DOIUrl":"10.2183/pjab.100.010","url":null,"abstract":"From the biota beneath the sea ice in Lake Saroma, which is adjacent to Sea of Okhotsk, a diatom culture of Saroma 16 was isolated. Strutted processes and a labiate process in Saroma 16 were characteristic of those in Thalassiosira nordenskioeldii. Similarity search analysis showed that the 826-bp rbcL-3P region sequence of this strain was 100% identical to multiple sequences registered as T. nordenskioeldii in a public database. The 4305-bp PCR-amplified mitochondrial cytochrome c oxidase subunit I (COI) gene (COI)-5P region of Saroma 16 included a 1060-bp open reading frame (ORF), which was interrupted by 934-bp and 2311-bp introns that included frame-shifted ORFs encoding reverse-transcriptase (RTase)-like proteins. Previous reports showed that a strain of the same species, CNS00052, originating from the East China Sea included no introns in the COI, whereas North Atlantic Ocean strains of the same species, such as CCMP992, CCMP993, and CCMP997, included a 2.3-kb intron in the same position as Saroma 16.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"100 2","pages":"140-148"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10978971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139723801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0