Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献_第5页

Cellular senescence as a source of chronic microinflammation that promotes the aging process. 细胞衰老是促进衰老过程的慢性微炎症的来源。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.014

Makoto Nakanishi

{"title":"Cellular senescence as a source of chronic microinflammation that promotes the aging process.","authors":"Makoto Nakanishi","doi":"10.2183/pjab.101.014","DOIUrl":"10.2183/pjab.101.014","url":null,"abstract":"Why and how do we age? This physiological phenomenon that we all experience remains a great mystery, largely unexplained even in this age of scientific and technological progress. Aging is a significant risk factor for numerous diseases, including cancer. However, underlying mechanisms responsible for this association remain to be elucidated. Recent findings have elucidated the significance of the accumulation of senescent cells and other inflammatory cells in organs and tissues with age, and their deleterious effects, such as the induction of inflammation in the microenvironment, as underlying factors contributing to organ dysfunction and disease development. Cellular senescence is a cellular phenomenon characterized by a permanent cessation of cell proliferation and secretion of several proinflammatory cytokines (senescence associated secretory phenotypes). Notably, the elimination of senescent cells from aging individuals has been demonstrated to alleviate age-related organ and tissue dysfunction, as well as various geriatric diseases. This review summarizes the molecular mechanisms by which senescent cells are induced and contribute to age-related diseases, as well as the technologies that ameliorate them.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 4","pages":"224-237"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Dynamics of the nucleoside diphosphate kinase protein DYNAMO2 correlates with the changes in the global GTP level during the cell cycle of Cyanidioschyzon merolae". 更正“核苷二磷酸激酶蛋白DYNAMO2的动力学与Cyanidioschyzon merolae细胞周期中全球GTP水平的变化相关”。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.022

Yuuta Imoto, Yuichi Abe, Kanji Okumoto, Mio Ohnuma, Haruko Kuroiwa, Tsuneyoshi Kuroiwa, Yukio Fujiki

引用次数: 0

Mechanisms of autophagosome formation. 自噬体的形成机制

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.005

Yuko Fujioka, Nobuo N. Noda

引用次数: 0

Toward structural understanding of eukaryotic transcription elongation. 真核生物转录延伸的结构理解。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.024

Shun-Ichi Sekine

引用次数: 0

Molecular basis of individual locomotor function: Integrated understanding of gene expression regulation in the development and homeostasis of the musculoskeletal system. 个体运动功能的分子基础：对肌肉骨骼系统发育和动态平衡中基因表达调控的综合理解。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.027

Hiroshi Asahara

{"title":"Molecular basis of individual locomotor function: Integrated understanding of gene expression regulation in the development and homeostasis of the musculoskeletal system.","authors":"Hiroshi Asahara","doi":"10.2183/pjab.101.027","DOIUrl":"10.2183/pjab.101.027","url":null,"abstract":"This review examines the molecular mechanisms controlling the development and homeostasis of the musculoskeletal system through gene expression regulation. It introduces key discoveries from basic transcriptional control to advanced mechanotransduction pathways, focusing on our contributions including the EMBRYS database for transcription factor expression analysis and the identification of RP58 in muscle development and Mohawk (Mkx) in tendon formation. We also elucidated the role of miR-140 as a critical regulator in cartilage development and homeostasis. This microRNA is specifically expressed in cartilage, promotes chondrogenesis, and is involved in protective mechanisms against cartilage degenerative diseases such as osteoarthritis. Our discovery of the PIEZO1-Mkx pathway provides a molecular mechanism linking mechanical stimuli to gene expression in tendons, explaining tissue adaptation and differences in motor abilities. Understanding these pathways offers new therapeutic strategies for tendon and ligament injuries, age-related decline, and cartilage diseases. Currently, we are proposing the concept of \"tenopenia\" to complement sarcopenia, addressing the mechanisms of age-related tendon deterioration. This integrated approach to the musculoskeletal system as an environment-responsive entity advances both fundamental science and clinical applications aimed at maintaining mobility throughout life.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 7","pages":"373-393"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12463553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenesis of type 2 diabetes in Japan and East Asian populations: Basic and clinical explorations. 日本和东亚人群2型糖尿病的发病机制：基础和临床探索。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.009

Yutaka Seino, Yuji Yamazaki

引用次数: 0

Development of phytochemical genomics: From decoding metabolome to functional genomics and biotechnology of plant metabolism. 植物化学基因组学的发展：从解码代谢组到功能基因组学和植物代谢生物技术。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.030

Kazuki Saito

{"title":"Development of phytochemical genomics: From decoding metabolome to functional genomics and biotechnology of plant metabolism.","authors":"Kazuki Saito","doi":"10.2183/pjab.101.030","DOIUrl":"10.2183/pjab.101.030","url":null,"abstract":"A characteristic feature of plants is their ability to produce a vast array of metabolites, a trait shaped by their evolution into sessile organisms. Over the past three decades, I have contributed to the development of phytochemical genomics, a field that emerged during the genomic era. Our research group established advanced analytical platforms for plant metabolomics by integrating state-of-the-art instruments with informatics tools. By combining genomics, transcriptomics, and metabolomics, we uncovered novel gene functions and identified new metabolites and gene-metabolite networks. Our study encompassed a broad spectrum of metabolites ranging from primary products, such as amino acids, sulfur-containing compounds, and lipids, to specialized (secondary) compounds, including flavonoids, alkaloids, and terpenoids. Initially, our focus was on the model plant Arabidopsis thaliana; however, we later included crops such as rice and tomato, as well as medicinal plants. This review highlights the key aspects of my research journey.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 8","pages":"445-484"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12674995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First English article of Yagi-Uda antenna. 八木田天线的第一篇英文文章。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.001

Qiang Chen

引用次数: 0

Peaks in weak lensing mass maps for cluster astrophysics and cosmology. 星系团天体物理学和宇宙学中弱透镜质量图的峰值。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.010

Masamune Oguri, Satoshi Miyazaki

{"title":"Peaks in weak lensing mass maps for cluster astrophysics and cosmology.","authors":"Masamune Oguri, Satoshi Miyazaki","doi":"10.2183/pjab.101.010","DOIUrl":"10.2183/pjab.101.010","url":null,"abstract":"Clusters of galaxies can be identified from the peaks in weak lensing aperture mass maps constructed from weak lensing shear catalogs. Such purely gravitational cluster selection differs considerably from traditional cluster selection based on the baryonic properties of clusters. In this review, we present the basics and applications of weak lensing shear-selected cluster samples. Detailed studies of the baryonic properties of shear-selected clusters shed new light on cluster astrophysics. The purely gravitational selection indicates that the selection function can be quantified more easily and robustly, which is crucial for deriving accurate cosmological constraints from the abundance of shear-selected clusters. Recent advances in shear-selected cluster studies are driven by the Subaru Hyper Suprime-Cam survey, in which more than 300 shear-selected clusters with a signal-to-noise ratio ＞ 5 were identified. It is argued that various systematic effects in cosmological analysis can be mitigated by carefully selecting the setup of the analysis, including the selection of kernel functions and the source galaxy sample.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 3","pages":"129-142"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conformational constraint in natural product synthesis. 天然产物合成中的构象约束。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.031

Minoru Isobe

{"title":"Conformational constraint in natural product synthesis.","authors":"Minoru Isobe","doi":"10.2183/pjab.101.031","DOIUrl":"10.2183/pjab.101.031","url":null,"abstract":"Natural products that exhibit significant biological activity often possess complex molecular structures such as caged frameworks, strained motifs, inherent instability, and many stereogenic carbon centers, etc. Achievement of those total syntheses always requires the powerful methodologies and judicious strategies to fulfill the stereochemical requirements of the target compounds. Building on our successful stereo-controlled syntheses, we have established the concept of conformational constraint, which renders the approach of reactants under a controlled manner during the bond-forming process through the best orbital overlap. Important factors that affect the proper orientation of substrates are (i) acyclic allyl strain, (ii) stereoelectronic effect, (iii) chelation control, etc. Established methodologies include (i) heteroatom directed conjugate addition for diastereoselective C-C bond formation, (ii) 100% α-selective C-glycosidation by using alkynyl-silane, (iii) cobalt acetylene chemistry for medium-size ring formation, followed by its functional group transformation. The author has named such total concept as conformational constraint and has illustrated it with the finished examples of total syntheses. These examples are taken from maytansine, okadaic acid, tautomycin, tetrodotoxin, ciguatoxin, etc.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 9","pages":"535-563"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12709059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145506585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0