Proceedings of the Japan Academy. Series B, Physical and Biological Sciences最新文献_第6页

Relationship between typical fall patterns and fall-related fractures in older Japanese adults. 日本老年人典型跌倒方式与跌倒相关骨折的关系

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.004

Minoru Yamada, Yusuke Terao, Iwao Kojima, Shu Tanaka, Hiroki Saegusa, Miho Nanbu, Shiho Soma, Hiroki Matsumoto, Masaya Saito, Kohei Okawa, Naoto Haga, Hidenori Arai

{"title":"Relationship between typical fall patterns and fall-related fractures in older Japanese adults.","authors":"Minoru Yamada, Yusuke Terao, Iwao Kojima, Shu Tanaka, Hiroki Saegusa, Miho Nanbu, Shiho Soma, Hiroki Matsumoto, Masaya Saito, Kohei Okawa, Naoto Haga, Hidenori Arai","doi":"10.2183/pjab.101.004","DOIUrl":"10.2183/pjab.101.004","url":null,"abstract":"This study explored the relationship between fall patterns and fall-related fractures in older adults. A cross-sectional survey was conducted among community-dwelling older adults in Maibara City, Japan, focusing on falls over the past three years. Among the 1,695 reported falls, 176 fractures occurred in 120 individuals. Backward or straight-down and sideways falls were more likely to result in fractures compared to forward falls, with odds ratios (95％ confidence interval) of 3.23 (2.08-5.02) and 3.68 (2.35-5.76), respectively. Falls triggered by slipping or loss of balance had higher fracture rates than those triggered by tripping. Specific fall patterns were associated with particular fractures, such as forearm and patella fractures from forward falls, spine fractures from backward or straight-down falls, and hip fractures from sideways falls. We conclude that the fracture risk varies significantly based on fall patterns, providing insights for enhancing fall prevention strategies.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 2","pages":"98-106"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural determination of mugineic acid, an iron(III)-chelating substance secreted from graminaceous plants for efficient iron uptake. 禾本科植物分泌的铁（III）螯合物质mugineic酸的结构测定。

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.007

Takanori Kobayashi, Naoko K Nishizawa

{"title":"Structural determination of mugineic acid, an iron(III)-chelating substance secreted from graminaceous plants for efficient iron uptake.","authors":"Takanori Kobayashi, Naoko K Nishizawa","doi":"10.2183/pjab.101.007","DOIUrl":"10.2183/pjab.101.007","url":null,"abstract":"Iron is an essential element for organisms, but its solubility in soil is often extremely low. Previously, plants were considered to take up iron only after its reduction to ferrous ions. Takagi reported that oat and rice secrete chelating substances that solubilize ferric iron in the rhizosphere for efficient iron uptake. In 1978, Takemoto et al. reported the chemical structure of an iron-chelating compound secreted from barley roots, designated as mugineic acid. Mugineic acid and its derivatives, collectively known as mugineic acid family phytosiderophores (MAs), chelate ferric iron using octahedral hexacoordination. The specific iron uptake system by MAs in graminaceous plants was later classified by Römheld and Marschner as Strategy II, in contrast to Strategy I for reduction-based iron uptake by non-graminaceous plants. Further studies on MAs by Japanese researchers led to the identification of their biosynthetic pathways, corresponding enzymes and encoding genes, their regulation mechanisms, and the production of iron deficiency-tolerant and iron-rich crops.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 2","pages":"55-67"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-recognized universality of Kozai oscillation on three-body dynamics. 重新认识三体动力学上Kozai振荡的普遍性。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.012

Masanori Iye, Takashi Ito

引用次数: 0

Particulate photocatalysts for water splitting to produce green hydrogen on a large scale. 颗粒光催化剂用于水分解，大规模生产绿色氢。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.035

Kazunari Domen

引用次数: 0

Dawn of photoredox catalysis. 光氧化还原催化的曙光。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.019

Munetaka Akita

{"title":"Dawn of photoredox catalysis.","authors":"Munetaka Akita","doi":"10.2183/pjab.101.019","DOIUrl":"10.2183/pjab.101.019","url":null,"abstract":"Photoredox catalysis, which facilitates organic transformations under visible-light irradiation, including sunlight, has garnered considerable attention as a cornerstone of green chemistry. Since the early days of this field around 2010, the author's group has made substantial contributions to its advancement. This review article provides a concise overview of the history and fundamental principles of photoredox catalysis, along with highlights of the achievements by the author's group. Although colorless organic compounds cannot be directly activated by visible light, photo-excited colored catalysts, with their two half-occupied frontier orbitals, play dual roles via electron transfer processes with organic substrates. The hole in the lower-energy orbital functions as a single-electron oxidant, whereas the electron in the higher-energy orbital acts as a single-electron reductant, enabling the formation of reactive radical intermediates from diverse organic compounds, including colorless ones. The discussion will focus on the key transformations developed by the author's group, including bimetallic photocatalysis, fluoroalkylation, and catalysis in aqueous media.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 5","pages":"274-301"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of protein chemical synthesis using peptide thioester synthetic blocks. 利用肽硫酯合成块进行蛋白质化学合成的研究进展。

IF 2.9 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.034

Saburo Aimoto, Toru Kawakami, Hironobu Hojo

引用次数: 0

The potential health risks of exposure to environmental chemicals - Global implications for future generations. 接触环境化学品的潜在健康风险——对子孙后代的全球影响。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.015

Reiko Kishi, Atsuko Ikeda, Rahel Mesfin Ketema

{"title":"The potential health risks of exposure to environmental chemicals - Global implications for future generations.","authors":"Reiko Kishi, Atsuko Ikeda, Rahel Mesfin Ketema","doi":"10.2183/pjab.101.015","DOIUrl":"10.2183/pjab.101.015","url":null,"abstract":"In 2001, we launched the Hokkaido Study, the first prospective birth cohort study in Japan. We are currently tracking the effects of environmental chemicals, using a life course approach. The study examines life circumstances after birth, and the longest follow-up to date is 20 years of age. We have measured prenatal exposure to dioxins, organochlorine pesticides, per- and polyfluoroalkyl substances, plasticizers such as di(2-ethylhexyl) phthalate, and bisphenol A. Our findings have mostly revealed that increased exposure to these environmental chemicals is linked to increased risk of lower birth size, effects on thyroid and steroid hormones, adipokine levels, as well as disruption of neurodevelopment, including causing asthma and respiratory symptoms. However, it should be noted that our findings also include protective or null findings, which may be due to low chemical concentrations or differences in prenatal or postnatal exposure. We would like to emphasize the importance of long-term continuation of the cohort, effective utilization of the data, and application of the results to environmental and health policies.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 4","pages":"197-215"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12321497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New molecules indispensable for hyaluronan degradation, HYBID (CEMIP/KIAA1199) and TMEM2 (CEMIP2): Differential roles in physiological and pathological non-neoplastic conditions. 透明质酸降解不可或缺的新分子HYBID （CEMIP/KIAA1199）和TMEM2 (CEMIP2)：在生理和病理非肿瘤条件中的差异作用。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.021

Hiroyuki Yoshida, Shintaro Inoue, Yasunori Okada

{"title":"New molecules indispensable for hyaluronan degradation, HYBID (CEMIP/KIAA1199) and TMEM2 (CEMIP2): Differential roles in physiological and pathological non-neoplastic conditions.","authors":"Hiroyuki Yoshida, Shintaro Inoue, Yasunori Okada","doi":"10.2183/pjab.101.021","DOIUrl":"10.2183/pjab.101.021","url":null,"abstract":"The biological activity of hyaluronan (HA), a major component of the extracellular matrix in vertebrate tissues, depends on its molecular weight, and thus its degradation is a critical process for HA biological functions. Here, we review the characteristics of newly discovered proteins essential for HA degradation, hyaluronan-binding protein involved in hyaluronan depolymerization (HYBID), also known as cell migration inducing hyaluronidase 1 (CEMIP) and KIAA1199, and transmembrane protein-2 (TMEM2; alias CEMIP2). Human and mouse forms of HYBID exert their HA-degrading activity in special microenvironments including recycling endosomes. Mouse TMEM2 functions as a cell-surface hyaluronidase for HA turnover in local tissues, lymph nodes, and the liver. In contrast, the role of human TMEM2 in HA degradation is the subject of much debate. HYBID expression is upregulated by proinflammatory factors such as histamine and interleukin-6 and downregulated by transforming growth factor-β. HYBID is involved in physiological HA turnover in human skin and joint tissues and plays an important role in their pathological destruction by accelerating HA degradation.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 6","pages":"317-338"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome-wide changes of protein translation levels for cell and organelle proliferation in a simple unicellular alga. 简单单细胞藻类细胞和细胞器增殖过程中蛋白质翻译水平的全基因组变化

IF 4.4 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.002

Yuko Mogi, Yoshitaka Matsuo, Yuiki Kondo, Tetsuya Higashiyama, Toshifumi Inada, Yamato Yoshida

{"title":"Genome-wide changes of protein translation levels for cell and organelle proliferation in a simple unicellular alga.","authors":"Yuko Mogi, Yoshitaka Matsuo, Yuiki Kondo, Tetsuya Higashiyama, Toshifumi Inada, Yamato Yoshida","doi":"10.2183/pjab.101.002","DOIUrl":"10.2183/pjab.101.002","url":null,"abstract":"Cell proliferation is a fundamental characteristic of organisms, driven by the holistic functions of multiple proteins encoded in the genome. However, the individual contributions of thousands of genes and the millions of protein molecules they express to cell proliferation are still not fully understood, even in simple eukaryotes. Here, we present a genome-wide translation map of cells during proliferation in the unicellular alga Cyanidioschyzon merolae, based on the sequencing of ribosome-protected messenger RNA fragments. Ribosome profiling has revealed both qualitative and quantitative changes in protein translation for each gene during cell division, driven by the large-scale reallocation of ribosomes. Comparisons of ribosome footprints from non-dividing and dividing cells allowed the identification of proteins involved in cell proliferation. Given that in vivo experiments on two selected candidate proteins identified a division-phase-specific mitochondrial nucleoid protein and a mitochondrial division protein, further analysis of the candidate proteins may offer key insights into the comprehensive mechanism that facilitate cell and organelle proliferation.","PeriodicalId":20707,"journal":{"name":"Proceedings of the Japan Academy. Series B, Physical and Biological Sciences","volume":"101 1","pages":"41-53"},"PeriodicalIF":4.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clones in blood and stratified epithelial cells, and their drivers. 血液和分层上皮细胞中的克隆及其驱动因素。

IF 4.6 3区综合性期刊

Proceedings of the Japan Academy. Series B, Physical and Biological Sciences Pub Date : 2025-01-01 DOI: 10.2183/pjab.101.026

Shigeru Chiba

引用次数: 0