中枢神经系统中不同巨噬细胞群的共同和独特特征。

IF 4.4 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Takahiro Masuda
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引用次数: 0

摘要

组织巨噬细胞在组织的发育、维持和修复中发挥着不可或缺的作用。小胶质细胞是中枢神经系统(CNS)的主要常驻免疫细胞,其功能是分布在整个脑实质的脑内巨噬细胞。除了小胶质细胞外,还有另一种不太明确的巨噬细胞类型,即CNS边界相关巨噬细胞(CAMs),这些细胞的存在已经被认识了几十年。随着近年来研究技术的进步,越来越多的研究集中在cam上,我们对cam的理解也开始提高。在这篇文章中,我们回顾了到目前为止已经阐明的CAMs的细胞特征和功能,特别关注CAMs和小胶质细胞之间的异同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Common and distinct features of diverse macrophage populations in the central nervous system.

Tissue-resident macrophages perform indispensable functions in the development, maintenance, and repair of tissues. Microglia are the primary resident immune cells in the central nervous system (CNS), functioning as intracerebral macrophages distributed throughout the brain parenchyma. In addition to microglia, there is another, less well-characterized type of macrophage known as CNS border-associated macrophages (CAMs), and the existence of these cells has been recognized for several decades. With recent advances in research technologies, an increasing number of studies have focused on CAMs, and our understanding of them has begun to improve. In this article, we review the cellular characteristics and functions of CAMs that have been elucidated thus far, with a particular focus on the similarities and differences between CAMs and microglia.

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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: The Proceedings of the Japan Academy Ser. B (PJA-B) is a scientific publication of the Japan Academy with a 90-year history, and covers all branches of natural sciences, except for mathematics, which is covered by the PJA-A. It is published ten times a year and is distributed widely throughout the world and can be read and obtained free of charge through the world wide web.
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