细胞衰老是促进衰老过程的慢性微炎症的来源。

IF 4.4 3区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Makoto Nakanishi
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引用次数: 0

摘要

我们为什么会变老,又是如何变老的?这种我们都经历过的生理现象仍然是一个很大的谜,即使在这个科技进步的时代,很大程度上也无法解释。衰老是包括癌症在内的许多疾病的重要风险因素。然而,这种关联的潜在机制仍有待阐明。最近的研究结果已经阐明了衰老细胞和其他炎症细胞在器官和组织中随着年龄增长而积累的重要性,以及它们的有害影响,如微环境中炎症的诱导,是导致器官功能障碍和疾病发展的潜在因素。细胞衰老是一种细胞现象,其特征是细胞增殖和几种促炎细胞因子的分泌永久停止(衰老相关的分泌表型)。值得注意的是,从衰老个体中消除衰老细胞已被证明可以减轻与年龄相关的器官和组织功能障碍,以及各种老年病。本文综述了衰老细胞诱导和促进衰老相关疾病的分子机制,以及改善衰老相关疾病的技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cellular senescence as a source of chronic microinflammation that promotes the aging process.

Why and how do we age? This physiological phenomenon that we all experience remains a great mystery, largely unexplained even in this age of scientific and technological progress. Aging is a significant risk factor for numerous diseases, including cancer. However, underlying mechanisms responsible for this association remain to be elucidated. Recent findings have elucidated the significance of the accumulation of senescent cells and other inflammatory cells in organs and tissues with age, and their deleterious effects, such as the induction of inflammation in the microenvironment, as underlying factors contributing to organ dysfunction and disease development. Cellular senescence is a cellular phenomenon characterized by a permanent cessation of cell proliferation and secretion of several proinflammatory cytokines (senescence associated secretory phenotypes). Notably, the elimination of senescent cells from aging individuals has been demonstrated to alleviate age-related organ and tissue dysfunction, as well as various geriatric diseases. This review summarizes the molecular mechanisms by which senescent cells are induced and contribute to age-related diseases, as well as the technologies that ameliorate them.

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来源期刊
CiteScore
6.60
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: The Proceedings of the Japan Academy Ser. B (PJA-B) is a scientific publication of the Japan Academy with a 90-year history, and covers all branches of natural sciences, except for mathematics, which is covered by the PJA-A. It is published ten times a year and is distributed widely throughout the world and can be read and obtained free of charge through the world wide web.
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