综合性期刊最新文献

{"title":"SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids","authors":"Sean J. Miller,&nbsp;Rahul M. Dhodapkar,&nbsp;Hande Eda Sutova,&nbsp;Yao Xue,&nbsp;Seunghoon Lee,&nbsp;Robert Logan,&nbsp;Chongzhao Ran,&nbsp;Sagar Bhatta,&nbsp;Ashley Gomm,&nbsp;In Gyoung Ju,&nbsp;Michael Heyang,&nbsp;Rayyan Y. Darji,&nbsp;Marcello DiStasio,&nbsp;Rudolph E. Tanzi,&nbsp;Can Zhang,&nbsp;Z. Jimmy Zhou,&nbsp;Brian P. Hafler","doi":"10.1126/sciadv.ads5006","DOIUrl":"10.1126/sciadv.ads5006","url":null,"abstract":"<div >While the etiology of Alzheimer’s disease remains unknown, there is growing support for the amyloid-β antimicrobial hypothesis. Amyloid-β, the main component of amyloid plaques in Alzheimer’s disease, has been shown to be generated in the presence of microbes. Entrapment of microbes by aggregated amyloid-β may serve as an innate immune response to pathogenic infections. To understand the association of amyloid-β plaques and pathogenic infections in the central nervous system, we obtained viable short-interval postmortem human retinal tissue and generated human retinal organoids that contain electrophysiologically active neurons. Here, we demonstrate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces amyloid-β extracellular protein aggregates in human retinal explants and retinal organoids. Last, pharmacological inhibition of neuropilin-1 resulted in reduced amyloid-β deposition in human retinal explants treated with SARS-CoV-2 Spike 1 protein. These results suggest that Spike 1 protein, during infection with SARS-CoV-2, can induce amyloid-β aggregation, which may be associated with the neurological symptoms experienced in COVID-19.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads5006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonreciprocal transport in a room-temperature chiral magnet","authors":"Daisuke Nakamura,&nbsp;Mu-Kun Lee,&nbsp;Kosuke Karube,&nbsp;Masahito Mochizuki,&nbsp;Naoto Nagaosa,&nbsp;Yoshinori Tokura,&nbsp;Yasujiro Taguchi","doi":"10.1126/sciadv.adw8023","DOIUrl":"10.1126/sciadv.adw8023","url":null,"abstract":"<div >Chiral magnets under broken time-reversal symmetry can give rise to rectification of moving electrons, called nonreciprocal transport. Several mechanisms, such as the spin fluctuation–induced chiral scattering and asymmetry in the electronic band dispersion with and without the relativistic spin-orbit interaction, have been proposed, but clear identification and theoretical description of these different contributions are desired for full understanding of nonreciprocal transport phenomena. Here, we investigate a chiral magnet Co₈Zn₉Mn₃ and find the nonreciprocal transport phenomena consisting of different contributions with distinct field and temperature dependence across the magnetic phase diagram over a wide temperature range including above room temperature. We successfully separate the nonreciprocal resistivity into different components and identify their mechanisms as spin fluctuation–induced chiral scattering and band asymmetry in a single material with the help of theoretical calculations.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw8023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultracompact 3D integrated photonic chip for high-fidelity high-dimensional quantum gates","authors":"Kangrui Wang,&nbsp;Dawei Lyu,&nbsp;Chengkun Cai,&nbsp;Tianhao Fu,&nbsp;Jue Wang,&nbsp;Qianke Wang,&nbsp;Jun Liu,&nbsp;Jian Wang","doi":"10.1126/sciadv.adv5718","DOIUrl":"10.1126/sciadv.adv5718","url":null,"abstract":"<div >Spatial modes of photons offer a rich encoding resource for high-dimensional quantum information processing. Multiplane light conversion (MPLC) enables spatial mode transformation and is applicable in both classical and quantum optics. Here, we demonstrate a polymer-based MPLC device, fabricated via femtosecond laser three-dimensional printing, that realizes high-dimensional quantum logic gates in an ultracompact format. Specifically, we design a three-dimensional Hadamard gate by training a diffractive neural network to generate the required phase distribution. The device is evaluated through quantum process tomography at the single-photon level within spatial modes, achieving a fidelity of 90%. Compared to traditional spatial light modulator–based implementations, our approach integrates spatial mode manipulation into a miniaturized photonic platform. These results highlight the feasibility of polymer-based MPLC for compact quantum logic and open possibilities for scalable, high-dimensional quantum information processing on integrated photonic chips.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adv5718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for the Research Article “Near-infrared light-triggered NO release for spinal cord injury repair” by Y. Jiang et al.","authors":"","doi":"10.1126/sciadv.adz6504","DOIUrl":"10.1126/sciadv.adz6504","url":null,"abstract":"","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guest Editorial Special Issue on Machine Learning for Radio Frequency Sensing","authors":"Avik Santra;Ashish Pandharipande;Pu Perry Wang;George Shaker;Bhavani Shankar Mysore;Guido Dolmans;Yan Chen;Negin Shariati Moghadam","doi":"10.1109/JSEN.2025.3573462","DOIUrl":"https://doi.org/10.1109/JSEN.2025.3573462","url":null,"abstract":"","PeriodicalId":447,"journal":{"name":"IEEE Sensors Journal","volume":"25 13","pages":"23163-23163"},"PeriodicalIF":4.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=11071932","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machining swarf formation–inspired fabrication of ferrofluidic helical miniature robots with multimodal locomotion capability","authors":"Xinjian Fan,&nbsp;Qinkai Chen,&nbsp;Mingtong Li,&nbsp;Zhengnan Wu,&nbsp;Dingwen Tong,&nbsp;Hui Xie,&nbsp;Zhan Yang,&nbsp;Lining Sun,&nbsp;Metin Sitti","doi":"10.1126/sciadv.ads4411","DOIUrl":"10.1126/sciadv.ads4411","url":null,"abstract":"<div >Magnetic helical robots (MHRs) have shown notable potential for targeted therapy. However, traditional fabrication methods are usually complex and expensive, and the prepared MHR’s locomotion is monotonous with limited capacity. Here, we present a cost-effective, customizable, and scalable fabrication craft of MHR, via using bent needle tips to engrave helical structures onto polymethyl methacrylate substrates and incorporating nanoparticle alignment strategies to create ferrofluidic helical miniature robots (FHMRs) with cross-scale size scopes. We then propose strategic magnetic driving methods that enable FHMRs with five powerful motion modes for negotiating various application scenarios. Experimental results show that FHMRs can move flexibly and effectively simulate thrombus removal within a vascular model by integrating multiple motion modes. Furthermore, modified FHMRs can swiftly deliver drugs to targeted areas, with the capability for phased release on surfaces of wrinkled physiological tissues. These advancements highlight the considerable potential of FHMRs for future applications in the biomedical field.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.ads4411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A self-supervised robotic system for autonomous contact-based spatial mapping of semiconductor properties","authors":"Alexander E. Siemenn,&nbsp;Basita Das,&nbsp;Kangyu Ji,&nbsp;Fang Sheng,&nbsp;Tonio Buonassisi","doi":"10.1126/sciadv.adw7071","DOIUrl":"10.1126/sciadv.adw7071","url":null,"abstract":"<div >Integrating robotically driven contact-based material characterization techniques into self-driving laboratories can enhance measurement quality, reliability, and throughput. While deep learning models support robust autonomy, current methods lack reliable pixel-precision positioning and require extensive labeled data. To overcome these challenges, we propose an approach for building self-supervised autonomy into contact-based robotic systems that teach the robot to follow domain expert measurement principles at high throughputs. We demonstrate the performance of this approach by autonomously driving a 4-DOF robotic probe for 24 hours to characterize semiconductor photoconductivity at 3025 uniquely predicted poses across a gradient of drop-casted perovskite film compositions, achieving throughputs of more than 125 measurements per hour. Spatially mapping photoconductivity onto each drop-casted film reveals compositional trends and regions of inhomogeneity, valuable for identifying manufacturing defects. With this self-supervised neural network–driven robotic system, we enable high-precision and reliable automation of contact-based characterization techniques at high throughputs, thereby allowing measurement of previously inaccessible yet important semiconductor properties for self-driving laboratories.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw7071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staphylococcus aureus LukMF′ targets neutrophils to promote skin and soft tissue infection","authors":"Daiane Boff,&nbsp;Ravishankar Chandrasekaran,&nbsp;Gregory Putzel,&nbsp;Rachel M. Kratofil,&nbsp;Xuhui Zheng,&nbsp;Ashley Castellaw,&nbsp;Kody Mansfield,&nbsp;Ikjot Sidhu,&nbsp;Avantika Dhabaria,&nbsp;Keenan A. Lacey,&nbsp;Sandra Gonzalez,&nbsp;Filadelfia Tadjibaeva,&nbsp;Beatrix Ueberheide,&nbsp;Cynthia Loomis,&nbsp;Alejandro Pironti,&nbsp;Silva Holtfreter,&nbsp;Shruti Naik,&nbsp;Victor J. Torres","doi":"10.1126/sciadv.adr5240","DOIUrl":"10.1126/sciadv.adr5240","url":null,"abstract":"<div >Pathogens have evolved to be highly adapted to their natural host. Community-associated methicillin-resistant <i>Staphylococcus aureus</i> USA300, for instance, is a lineage responsible for the epidemic of skin and soft tissue infections (SSTIs) in humans. Owing to its human tropism, mechanisms that enabled the rise of USA300 as a major skin pathogen remain incompletely defined. By leveraging a rodent-adapted strain of <i>S. aureus</i>, we developed a natural model of SSTIs. We found that LukMF′, a pore-forming leukocidin homolog to the human-specific LukSF-PV toxin, drives skin pathology in mice. LukMF′ lyses neutrophils via the chemokine receptor CCR1, which in turn fuels inflammatory pathology and microbial survival within the infectious nidus. Ablation of CCR1, depletion of neutrophils, or vaccination with LukMF′ all protected mice from skin pathology. Thus, these data support epidemiological studies linking leukocidins with human SSTIs and highlight the power of natural models to unearth potential targets to curtail infections.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adr5240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and immunogenicity of intranasal parainfluenza virus type 5 (PIV5)–vectored COVID-19 vaccine in adults and teens in an open-label phase 1 trial","authors":"Paul Spearman,&nbsp;Hong Jin,&nbsp;Peng Xiao,&nbsp;Kristeene Knopp,&nbsp;Henry Radziewicz,&nbsp;Marinka Tellier,&nbsp;Sasha E. Larsen,&nbsp;Bryan J. Berube,&nbsp;Xiao Song,&nbsp;Jamie Kidd,&nbsp;Karnail Singh,&nbsp;Zhuo Li,&nbsp;Maria Cristina Gingerich,&nbsp;Samuel Wu,&nbsp;Susan P. John,&nbsp;Angela Branche,&nbsp;Ann R. Falsey,&nbsp;Rhea Coler,&nbsp;Francois J. Villinger,&nbsp;Biao He","doi":"10.1126/sciadv.adw0896","DOIUrl":"10.1126/sciadv.adw0896","url":null,"abstract":"<div >COVID-19 continues causing substantial mortality despite existing FDA-approved COVID-19 vaccines. An effective COVID-19 vaccine providing durable immunity with minimal reactogenicity is needed. CVXGA1, a PIV5-based intranasal COVID-19 vaccine expressing the Spike (S) protein of SARS-CoV-2, was evaluated in this phase 1 study in adults and teens. CVXGA1 was well tolerated without serious adverse events (AEs) or fever reported. Solicited local and systemic AEs were mostly mild. CVXGA1 elicited S-specific serum and mucosal antibodies and CD8⁺ cytotoxic T lymphocyte responses in all groups. Significantly lower rates of symptomatic COVID-19 infection were reported in groups receiving high-dose CVXGA1 (HD) compared to that in the group receiving low-dose CVXGA1 (LD) during the SARS-CoV-2 delta and omicron waves. The data indicate that CVXGA1 is a potentially effective intranasal COVID-19 vaccine that is immunogenic with minimal reactogenicity.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 27","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw0896","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-consistent hardness measurements spanning eleven decades of strain rate on a single material surface.","authors":"Luciano Borasi, Christopher A Schuh","doi":"10.1038/s41467-025-61445-2","DOIUrl":"https://doi.org/10.1038/s41467-025-61445-2","url":null,"abstract":"<p><p>A comprehensive understanding of material strength across strain rates typically requires the combination of results from different methods, which often vary in loading conditions and/or sampled volumes, leading to discrepancies in material behavior. This study presents a microindentation approach to measure hardness covering eleven orders of magnitude in strain rate, from quasi-static to phonon drag-dominated rates, on a single material surface under uniform testing conditions. By engineering the geometry of impactors used in laser induced particle impact testing, we extend the breadth of accessible strain rates, including multiple distinct rates exceeding 10⁵ s⁻¹. This self-consistent approach provides clearer insights into high-rate deformation mechanisms. Our results demonstrate a gradual increase in hardness with strain rate from quasi-static up to ultra-high rates, where a sharp upturn in hardness is observed.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"16 1","pages":"6148"},"PeriodicalIF":14.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}